{
  "schema_version": "chamgap-public-evidence-check-1.0",
  "public_id": "v2997-s0",
  "verdict_number": "2997",
  "title": "Whey protein preload × acute or several-day postprandial glucose",
  "view_version": "1.0",
  "view_created_date": "2026-10-16",
  "criteria_version": "1.0",
  "criteria_date": "2026-10-06",
  "review_date": null,
  "legacy_evidence_date": "2026-09-07",
  "review_scope": {
    "materials_read": "Existing review summaries and stored records of methodological application",
    "clinical_papers_directly_read": false,
    "new_clinical_search": false,
    "limitation": "Existing stored summary and preserved methodology application records. External papers, abstracts, registration, protocols, SAPs, original result tables and support disclosures are unread, and review of existing content remains incomplete.",
    "date_meaning": "This is the date the stored materials were checked, not the date of a new search of the clinical literature."
  },
  "claim_context": {
    "population": "Stored material concerns adults with type 2 diabetes in a non-insulin-treated context. Acute 15-person and 7-day 18-person samples belong to separate reports and are not summed. Study-specific eligibility, baseline medication, HbA1c, renal/complication status and period-specific completion/analysis denominators are unverified.",
    "intervention": "Within the parent record’s whey preload 10–30 minutes before meals, preserve acute 50 g at 30 minutes before a meal and a premeal 15.6 g protein drink as research identifiers. Product, formulation and actual intake remain separately unverified. Whey plus guar and MCT plus WPI are different combination interventions.",
    "dose": "Preserve only original acute 50 g and premeal 15.6 g protein-drink wording. Do not turn 15.6 g into total drink volume or an effective dose for all products. No new daily/cumulative doses, intake sequence or dosing instructions are calculated or created.",
    "comparator": "Acute control-drink details are unverified. The 7-day test drink at approximately 100 kcal and control at approximately 34 kcal form a non-isocaloric comparison. This does not certify an isolated ingredient effect at equal calories; no new calorie difference or cumulative calories are calculated.",
    "endpoint": "Distinguish acute 180-minute glucose response 28% lower, insulin 105% higher and a GLP-1 increase. The 7-day glucose iAUC 1.6±0.6 versus 2.1±0.9/P=.003 is not the exact value/P for time metrics. Units, the meaning of ±, direct effects/CIs and denominators are unverified. Null primary 24-hour/daytime iAUC for MCT plus WPI is a separate combination result.",
    "duration": "Distinguish 180 minutes after an acute meal from 7 days of free-living exposure. The combination report’s 24-hour/daytime endpoints do not establish long-term follow-up duration. Long-term whey-only HbA1c, complications, medication reduction and post-intervention effects are not directly established.",
    "excluded_extensions": [
      "Transferring acute/7-day surrogates or mechanistic hormones into long-term HbA1c, complications or medication reduction",
      "Certifying a non-isocaloric comparison as an isolated ingredient effect at equal calories",
      "Substituting MCT plus WPI or whey plus guar for whey alone",
      "Summing shared reports, crossover periods or repeated measurements into new unique-trial, participant or independent-replication totals",
      "Filling original subclaim-C missing values from parent C50, axes or a new verdict",
      "Creating new effects, CIs, dose/calorie totals, dosing instructions, medication changes or treatment guidance"
    ]
  },
  "requirements": [
    {
      "item_id": "N01",
      "question_type": "Evidence condition",
      "question": "Which short-term glucose claim is being checked?",
      "needed": "Selected acute or several-day postprandial glucose claim",
      "role": "Required",
      "role_reason": "This condition connects Selected acute or several-day postprandial glucose claim with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for Selected acute or several-day postprandial glucose claim must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Material for the selected question's postprandial measures, times, direct comparisons and populations, plus boundary review. Do not fill the subclaim score from its parent. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The selected claim is lower acute or several-day postprandial glucose, originally graded C, with a note that two small studies reported positive signals. Absent subclaim score/status is distinguished from parent C50 and uncertain long-term benefit.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Material for the selected question's postprandial measures, times, direct comparisons and populations, plus boundary review. Do not fill the subclaim score from its parent.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Material for the selected question's postprandial measures, times, direct comparisons and populations, plus boundary review. Do not fill the subclaim score from its parent."
    },
    {
      "item_id": "N02",
      "question_type": "Evidence condition",
      "question": "What did the acute 15-person trial report for glucose?",
      "needed": "Original estimate of 180-minute glucose response",
      "role": "Required",
      "role_reason": "This condition connects Original estimate of 180-minute glucose response with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for Original estimate of 180-minute glucose response must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: The definition of the 180-minute response, original curves/measures, direct comparator, absolute effect/CI, exact P value and analysis denominator. No new absolute effect or numerical example is calculated from 28%. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Jakubowicz's randomized crossover trial in 15 participants used 50 g whey 30 minutes before a meal. Preserve the original 28% lower 180-minute glucose response; do not transfer this into a glucose concentration at a specific time or an absolute between-condition effect/CI.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "The definition of the 180-minute response, original curves/measures, direct comparator, absolute effect/CI, exact P value and analysis denominator. No new absolute effect or numerical example is calculated from 28%.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "The definition of the 180-minute response, original curves/measures, direct comparator, absolute effect/CI, exact P value and analysis denominator. No new absolute effect or numerical example is calculated from 28%."
    },
    {
      "item_id": "N03",
      "question_type": "Evidence condition",
      "question": "Are insulin and GLP-1 the same outcomes as glucose or complications?",
      "needed": "Separate mechanistic hormones from postprandial glucose",
      "role": "Required",
      "role_reason": "This condition connects Separate mechanistic hormones from postprandial glucose with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for Separate mechanistic hormones from postprandial glucose must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Each hormone's times, denominators, effects/CIs and actual clinical outcomes. Do not transfer 105% into glucose reduction or complication prevention. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The key report records glucose 28% lower and insulin 105% higher, with a GLP-1 increase. Insulin and GLP-1 are mechanistic outcomes; an exact GLP-1 value is not established by this summary.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Each hormone's times, denominators, effects/CIs and actual clinical outcomes. Do not transfer 105% into glucose reduction or complication prevention.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Each hormone's times, denominators, effects/CIs and actual clinical outcomes. Do not transfer 105% into glucose reduction or complication prevention."
    },
    {
      "item_id": "N04",
      "question_type": "Evidence condition",
      "question": "What was the 7-day free-living iAUC result?",
      "needed": "Smith's 7-day postprandial glucose iAUC",
      "role": "Required",
      "role_reason": "This condition connects Smith's 7-day postprandial glucose iAUC with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for Smith's 7-day postprandial glucose iAUC must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: iAUC units/baseline, curve interval, analysis, direct between-condition CI, the type of ± statistic, period-specific denominators and missing data. This records needed materials; no new research was executed.",
      "current_reports": [
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "In Smith's free-living crossover trial with 18 participants, iAUC was 1.6±0.6 versus 2.1±0.9, P=.003. Do not invent unrecorded units, between-condition differences, CIs or the meaning of ±.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "iAUC units/baseline, curve interval, analysis, direct between-condition CI, the type of ± statistic, period-specific denominators and missing data.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "iAUC units/baseline, curve interval, analysis, direct between-condition CI, the type of ± statistic, period-specific denominators and missing data."
    },
    {
      "item_id": "N05",
      "question_type": "Evidence condition",
      "question": "Are time above range and iAUC distinct outcomes?",
      "needed": "Separate time above range, time in euglycemia and postprandial iAUC",
      "role": "Required",
      "role_reason": "This condition connects Separate time above range, time in euglycemia and postprandial iAUC with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for Separate time above range, time in euglycemia and postprandial iAUC must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Definitions of high/normal glucose ranges, valid CGM time, missing data, outcome-specific effects/CIs and prespecified hierarchy. Do not copy iAUC P=.003 to other time metrics. This records needed materials; no new research was executed.",
      "current_reports": [
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Smith's endpoint description lists postprandial glucose iAUC and time above range; the citation title mentions increased time in euglycemia. Exact time changes, range thresholds and outcome-specific effects/CIs are not established by this summary.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Definitions of high/normal glucose ranges, valid CGM time, missing data, outcome-specific effects/CIs and prespecified hierarchy. Do not copy iAUC P=.003 to other time metrics.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Definitions of high/normal glucose ranges, valid CGM time, missing data, outcome-specific effects/CIs and prespecified hierarchy. Do not copy iAUC P=.003 to other time metrics."
    },
    {
      "item_id": "N06",
      "question_type": "Evidence condition",
      "question": "Are acute 180-minute and 7-day measures the same time point?",
      "needed": "Time boundaries for one-meal response and several-day free-living exposure",
      "role": "Required",
      "role_reason": "This condition connects Time boundaries for one-meal response and several-day free-living exposure with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for Time boundaries for one-meal response and several-day free-living exposure must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Report-specific time origins, meal/measurement windows, repeats, period-specific analysis denominators and post-intervention material. Do not turn short-term reduction into long-term HbA1c benefit. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The acute 180-minute and 7-day free-living studies have different times and designs. Parent duration is 180 minutes after a single meal; do not copy this to every 7-day outcome or long-term follow-up.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Report-specific time origins, meal/measurement windows, repeats, period-specific analysis denominators and post-intervention material. Do not turn short-term reduction into long-term HbA1c benefit.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Report-specific time origins, meal/measurement windows, repeats, period-specific analysis denominators and post-intervention material. Do not turn short-term reduction into long-term HbA1c benefit."
    },
    {
      "item_id": "N07",
      "question_type": "Evidence condition",
      "question": "Were the formulation and protein amount the same?",
      "needed": "Acute 50 g whey and a 15.6 g protein drink",
      "role": "Required",
      "role_reason": "This condition connects Acute 50 g whey and a 15.6 g protein drink with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for Acute 50 g whey and a 15.6 g protein drink must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Report-specific product/ingredient, protein content, manufacturing/formulation, comparator and actual exposure material. No new dose/total calculations or dosing instructions. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The parent records acute 50 g and a premeal 15.6 g protein drink. Do not turn 15.6 g into total drink volume, an effective dose for all whey products or a long-term whey-only formulation.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Report-specific product/ingredient, protein content, manufacturing/formulation, comparator and actual exposure material. No new dose/total calculations or dosing instructions.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Report-specific product/ingredient, protein content, manufacturing/formulation, comparator and actual exposure material. No new dose/total calculations or dosing instructions."
    },
    {
      "item_id": "N08",
      "question_type": "Evidence condition",
      "question": "Was the 7-day comparator isocaloric?",
      "needed": "Calories and nutritional composition of test/control drinks",
      "role": "Required",
      "role_reason": "This condition connects Calories and nutritional composition of test/control drinks with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for Calories and nutritional composition of test/control drinks must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Test/control composition, calories, taste/blinding, meal compensation, total intake and activity changes. No new calorie difference or cumulative calories are calculated. This records needed materials; no new research was executed.",
      "current_reports": [
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Stored wording states approximately 100 kcal for the 7-day test drink and approximately 34 kcal for control, with a non-isocaloric comparison. This does not certify an isolated protein effect at equal calories.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Test/control composition, calories, taste/blinding, meal compensation, total intake and activity changes. No new calorie difference or cumulative calories are calculated.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Test/control composition, calories, taste/blinding, meal compensation, total intake and activity changes. No new calorie difference or cumulative calories are calculated."
    },
    {
      "item_id": "N09",
      "question_type": "Evidence condition",
      "question": "Are preload timing and meal conditions linked?",
      "needed": "Preload timing and meal/comparator conditions",
      "role": "Required",
      "role_reason": "This condition connects Preload timing and meal/comparator conditions with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for Preload timing and meal/comparator conditions must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Report-specific meal/preload times, meal composition, control procedures, measurement and adherence source material. Preserve research identifiers without creating an intake sequence or dosing instructions. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The parent ingredient wording is preload 10–30 minutes before meals; the key acute trial used 30 minutes before a meal. Identical meals and detailed postprandial measurement/comparator conditions for each report remain separately unverified.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Report-specific meal/preload times, meal composition, control procedures, measurement and adherence source material. Preserve research identifiers without creating an intake sequence or dosing instructions.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Report-specific meal/preload times, meal composition, control procedures, measurement and adherence source material. Preserve research identifiers without creating an intake sequence or dosing instructions."
    },
    {
      "item_id": "N10",
      "question_type": "Evidence condition",
      "question": "Were participants and glucose-lowering medications comparable?",
      "needed": "Type 2 diabetes and non-insulin-treated population boundaries",
      "role": "Required",
      "role_reason": "This condition connects Type 2 diabetes and non-insulin-treated population boundaries with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for Type 2 diabetes and non-insulin-treated population boundaries must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Report-specific eligibility, baseline characteristics and medication/meal cointerventions. Do not establish effects in insulin-treated or other populations, or give medication-change instructions. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The key study concerns 15 adults with type 2 diabetes, and the parent research description records non-insulin-treated adults. Study-specific baseline medication, renal/complication status, HbA1c and glucose details are unverified.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Report-specific eligibility, baseline characteristics and medication/meal cointerventions. Do not establish effects in insulin-treated or other populations, or give medication-change instructions.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Report-specific eligibility, baseline characteristics and medication/meal cointerventions. Do not establish effects in insulin-treated or other populations, or give medication-change instructions."
    },
    {
      "item_id": "N11",
      "question_type": "Evidence condition",
      "question": "Are original crossover denominators and period effects known?",
      "needed": "Crossover design, repeated measurements and denominators for 15/18 participants",
      "role": "Required",
      "role_reason": "This condition connects Crossover design, repeated measurements and denominators for 15/18 participants with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for Crossover design, repeated measurements and denominators for 15/18 participants must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Allocation sequence, period-specific analysis populations, attrition, repeated-measures models and missing-measurement source material. Do not count repeats in the same people as new participants or independent trials. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Original sample sizes are 15 and 18 and both short-term studies use crossover designs. Sequence, washout, carryover, period effects, missing data/analysis denominators and measurement counts for every meal remain separately unverified.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Allocation sequence, period-specific analysis populations, attrition, repeated-measures models and missing-measurement source material. Do not count repeats in the same people as new participants or independent trials.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Allocation sequence, period-specific analysis populations, attrition, repeated-measures models and missing-measurement source material. Do not count repeats in the same people as new participants or independent trials."
    },
    {
      "item_id": "N12",
      "question_type": "Evidence condition",
      "question": "Did registered and published primary outcomes agree?",
      "needed": "Historical Smith registered/published outcome-hierarchy mismatch",
      "role": "Required",
      "role_reason": "This condition connects Historical Smith registered/published outcome-hierarchy mismatch with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for Historical Smith registered/published outcome-hierarchy mismatch must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Registration dates/change history, protocol/SAP, original published outcome wording and the exact mismatch. Preserve the historical mismatch without new registry verification or regrading. This records needed materials; no new research was executed.",
      "current_reports": [
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The parent records a mismatch between the registered primary outcome and the published primary outcome in Smith, with a prespecified-hierarchy concern. ISRCTN17563146 alone does not establish which endpoints/times differed in this work.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Registration dates/change history, protocol/SAP, original published outcome wording and the exact mismatch. Preserve the historical mismatch without new registry verification or regrading.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Registration dates/change history, protocol/SAP, original published outcome wording and the exact mismatch. Preserve the historical mismatch without new registry verification or regrading."
    },
    {
      "item_id": "N13",
      "question_type": "Evidence condition",
      "question": "Is null primary iAUC for MCT plus WPI a whey-only result?",
      "needed": "24-hour/daytime endpoints of combined MCT plus WPI",
      "role": "Required",
      "role_reason": "This condition connects 24-hour/daytime endpoints of combined MCT plus WPI with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for 24-hour/daytime endpoints of combined MCT plus WPI must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Product/components, comparator, duration, population/denominators, each primary iAUC effect/CI and exact P value. Null findings do not create equivalence, zero effect or a whey-only conclusion. This records needed materials; no new research was executed.",
      "current_reports": [
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Zameer 2025 is an MCT-plus-WPI crossover trial recording null primary 24-hour/daytime glucose iAUC. Do not substitute it for the same formulation or a direct contrary effect in the short-term whey-only question.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Product/components, comparator, duration, population/denominators, each primary iAUC effect/CI and exact P value. Null findings do not create equivalence, zero effect or a whey-only conclusion.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Product/components, comparator, duration, population/denominators, each primary iAUC effect/CI and exact P value. Null findings do not create equivalence, zero effect or a whey-only conclusion."
    },
    {
      "item_id": "N14",
      "question_type": "Evidence condition",
      "question": "Is the longer whey-plus-guar report identified?",
      "needed": "Combined long-term material versus whey-only/report identification",
      "role": "Required",
      "role_reason": "This condition connects Combined long-term material versus whey-only/report identification with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for Combined long-term material versus whey-only/report identification must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: The original guar-combination bibliography, components, duration, results, denominators and isolated contribution. Do not create trial, participant or effect numbers for an unidentified report. This records needed materials; no new research was executed.",
      "current_reports": [],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The parent mentions whey plus guar in longer-term material, but the current three evidence/citation reports do not separately identify that guar report's bibliography, duration, denominator or effect.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "The original guar-combination bibliography, components, duration, results, denominators and isolated contribution. Do not create trial, participant or effect numbers for an unidentified report.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "The original guar-combination bibliography, components, duration, results, denominators and isolated contribution. Do not create trial, participant or effect numbers for an unidentified report."
    },
    {
      "item_id": "N15",
      "question_type": "Evidence condition",
      "question": "Do short-term glucose findings establish long-term HbA1c or complications?",
      "needed": "Postprandial surrogates, long-term whey-only benefit and medication-replacement boundaries",
      "role": "Required",
      "role_reason": "This condition connects Postprandial surrogates, long-term whey-only benefit and medication-replacement boundaries with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for Postprandial surrogates, long-term whey-only benefit and medication-replacement boundaries must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Direct long-term whey-only HbA1c, clinical-complication and medication outcomes, comparisons/CIs and denominators. No new diabetes-treatment/medication-replacement conclusions or instructions. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The other existing subclaim grades long-term whey-only HbA1c/complication benefit ? and notes combination interventions in longer trials. Do not transfer short-term glucose, insulin or GLP-1 changes into those clinical outcomes or medication reduction.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Direct long-term whey-only HbA1c, clinical-complication and medication outcomes, comparisons/CIs and denominators. No new diabetes-treatment/medication-replacement conclusions or instructions.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Direct long-term whey-only HbA1c, clinical-complication and medication outcomes, comparisons/CIs and denominators. No new diabetes-treatment/medication-replacement conclusions or instructions."
    },
    {
      "item_id": "N16",
      "question_type": "Evidence condition",
      "question": "Do unverified effects/CIs and statistical units remain explicit?",
      "needed": "Distinguish relative response, iAUC, ± values and denominators",
      "role": "Required",
      "role_reason": "This condition connects Distinguish relative response, iAUC, ± values and denominators with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for Distinguish relative response, iAUC, ± values and denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original tables, models, units, variance definitions, CIs and measurement times/denominators for each outcome. No invented numbers, new effects/intervals or unit conversions. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Retain original scope for 28% glucose response, 105% insulin, and iAUC 1.6±0.6 versus 2.1±0.9/P=.003. Units, the meaning of ±, absolute between-condition effects/CIs and exact P values for each comparison are not all supplied at the same level.",
      "condition_status": "Unverified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Original tables, models, units, variance definitions, CIs and measurement times/denominators for each outcome. No invented numbers, new effects/intervals or unit conversions.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original tables, models, units, variance definitions, CIs and measurement times/denominators for each outcome. No invented numbers, new effects/intervals or unit conversions."
    },
    {
      "item_id": "N17",
      "question_type": "Evidence condition",
      "question": "Does the same direction establish strict independent replication?",
      "needed": "Short-term designs, industry involvement and combination differences",
      "role": "Required",
      "role_reason": "This condition connects Short-term designs, industry involvement and combination differences with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for Short-term designs, industry involvement and combination differences must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Independent studies addressing the same question, formulation, calories/comparator, population and prespecified outcomes, plus funding/analysis roles. No new pooled effect, unique-trial count or participant total. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The parent's counterview records supporting postprandial direction in different short designs while retaining small-sample, industry, calorie and combination limitations. Preserve parent R1/I0 without certifying new independent replication.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Independent studies addressing the same question, formulation, calories/comparator, population and prespecified outcomes, plus funding/analysis roles. No new pooled effect, unique-trial count or participant total.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Independent studies addressing the same question, formulation, calories/comparator, population and prespecified outcomes, plus funding/analysis roles. No new pooled effect, unique-trial count or participant total."
    },
    {
      "item_id": "N18",
      "question_type": "Evidence condition",
      "question": "Are shared reports/populations counted as new independent trials?",
      "needed": "Shared parent, subclaim, report and cohort relationships",
      "role": "Required",
      "role_reason": "This condition connects Shared parent, subclaim, report and cohort relationships with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for Shared parent, subclaim, report and cohort relationships must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original study/report identities, cohorts and analysis-population links. Unique-trial and unique-participant totals are unverified. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Parent 2997 and existing subclaims share the context of the same three reports. Sheet/report counts, crossover periods, subgroups and repeated measurements are not summed into new independent trials or participants.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Original study/report identities, cohorts and analysis-population links. Unique-trial and unique-participant totals are unverified.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original study/report identities, cohorts and analysis-population links. Unique-trial and unique-participant totals are unverified."
    },
    {
      "item_id": "N19",
      "question_type": "Evidence condition",
      "question": "Which materials were actually read?",
      "needed": "Stored parent summary versus external access",
      "role": "Required",
      "role_reason": "This condition connects Stored parent summary versus external access with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for Stored parent summary versus external access must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Actually acquired original papers, supplements, registration/plans and reading records. No separate external link/screen tests or new lookup. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The complete parent summary is read for production and preserved as a complete byte copy. External abstracts, full texts, registration and protocols/SAPs are unread. URLs, PMCIDs or registration identifiers do not establish actual reading or successful access.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Actually acquired original papers, supplements, registration/plans and reading records. No separate external link/screen tests or new lookup.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Actually acquired original papers, supplements, registration/plans and reading records. No separate external link/screen tests or new lookup."
    },
    {
      "item_id": "N20",
      "question_type": "Evidence condition",
      "question": "Where are original bibliography and registry identifiers recorded?",
      "needed": "Evidence registration field versus citation bibliography",
      "role": "Required",
      "role_reason": "This condition connects Evidence registration field versus citation bibliography with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for Evidence registration field versus citation bibliography must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Paper-registry identity, dates and content. A registration identifier does not prove prospective status or actual reading. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Link original citation PMIDs, PMCIDs, DOIs and PubMed URLs unchanged. Preserve evidence NCT/ISRCTN wording separately from absent registration wording in citations. No new registry URLs are inferred from identifiers.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Paper-registry identity, dates and content. A registration identifier does not prove prospective status or actual reading.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Paper-registry identity, dates and content. A registration identifier does not prove prospective status or actual reading."
    },
    {
      "item_id": "N21",
      "question_type": "Evidence condition",
      "question": "What is the scope of historical verification wording?",
      "needed": "Original Korean/English, subclaim notes and historical cross-check wording",
      "role": "Required",
      "role_reason": "This condition connects Original Korean/English, subclaim notes and historical cross-check wording with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for Original Korean/English, subclaim notes and historical cross-check wording must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Review of originals, translation and corrections. Do not label historical verification as a new completed clinical review or independent clinical validation. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Preserve selected claim/note, parent Korean/English, historical cross-check wording and citation statements that findings were checked. This work prepares materials; review of existing content and claim boundaries remains incomplete.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Review of originals, translation and corrections. Do not label historical verification as a new completed clinical review or independent clinical validation.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Review of originals, translation and corrections. Do not label historical verification as a new completed clinical review or independent clinical validation."
    },
    {
      "item_id": "N22",
      "question_type": "Evidence condition",
      "question": "Are selected-subclaim values separate from parent score and axes?",
      "needed": "Original subclaim grade/note, absent score/status and parent context",
      "role": "Required",
      "role_reason": "This condition connects Original subclaim grade/note, absent score/status and parent context with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for Original subclaim grade/note, absent score/status and parent context must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Review of the selected question, original values and parent boundary. No new scores, axes, efficacy grades or verdict changes. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Preserve original selected grade/note and leave absent subclaim score/status unrecorded. Parent C50/Caution and all axes, including unrecorded precision, remain parent context and do not fill the selected short-term glucose score/axes or certify independence.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Review of the selected question, original values and parent boundary. No new scores, axes, efficacy grades or verdict changes.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Review of the selected question, original values and parent boundary. No new scores, axes, efficacy grades or verdict changes."
    },
    {
      "item_id": "N23",
      "question_type": "Evidence condition",
      "question": "What are the original evidence date and empty correction history?",
      "needed": "Separate evidence date, corrections and production date",
      "role": "Required",
      "role_reason": "This condition connects Separate evidence date, corrections and production date with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for Separate evidence date, corrections and production date must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Actual corrections/follow-up material and original/change records when acquired. Existing wording and dates are preserved. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Original evidence date is 2026-09-07, corrections are an empty list and deliberation is an empty string. Distinguish these from production/review dates without certifying absence of external corrections.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Actual corrections/follow-up material and original/change records when acquired. Existing wording and dates are preserved.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Actual corrections/follow-up material and original/change records when acquired. Existing wording and dates are preserved."
    },
    {
      "item_id": "N24",
      "question_type": "Evidence condition",
      "question": "Are funding, product support, employee authors and analysis roles distinguished?",
      "needed": "Four report-specific industry/support aspects",
      "role": "Required",
      "role_reason": "This condition connects Four report-specific industry/support aspects with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for Four report-specific industry/support aspects must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Each report's original funding, product/device support, author affiliations and analysis/publication roles. Do not upgrade parent independence axes into new certification. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Jakubowicz records health-ministry/Milk Council support, Smith product/industry support and investigator involvement, and Zameer mixed academic/product-related support. Investigator involvement does not automatically establish employee authorship; analysis/reporting roles and product-support details remain separately unverified.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Each report's original funding, product/device support, author affiliations and analysis/publication roles. Do not upgrade parent independence axes into new certification.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Each report's original funding, product/device support, author affiliations and analysis/publication roles. Do not upgrade parent independence axes into new certification."
    },
    {
      "item_id": "N25",
      "question_type": "Evidence condition",
      "question": "Are allocation, blinding, measurement and selective reporting known?",
      "needed": "Original study designs and detailed bias conditions",
      "role": "Required",
      "role_reason": "This condition connects Original study designs and detailed bias conditions with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for Original study designs and detailed bias conditions must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Methods, registration/protocol/SAP, original analysis tables and change history. A design label does not establish official RoB/GRADE certification or completed review. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Preserve crossover design, calorie imbalance and outcome-hierarchy issues. Allocation concealment, sequence/period effects, blinding, CGM/glucose measurement, missing data and selective-reporting details remain separately unverified.",
      "condition_status": "Unverified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Methods, registration/protocol/SAP, original analysis tables and change history. A design label does not establish official RoB/GRADE certification or completed review.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Methods, registration/protocol/SAP, original analysis tables and change history. A design label does not establish official RoB/GRADE certification or completed review."
    },
    {
      "item_id": "N26",
      "question_type": "Evidence condition",
      "question": "Are adherence, cointerventions and actual exposure preserved?",
      "needed": "Actual intervention, control and shared management by report",
      "role": "Required",
      "role_reason": "This condition connects Actual intervention, control and shared management by report with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for Actual intervention, control and shared management by report must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original cointervention, adherence, exposure and intervention-deviation material. No new totals/repetition counts, cumulative-exposure calculations or dosing instructions. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Preserve original premeal formulation/content, calorie imbalance and combinations as research identifiers. Actual intake adherence, other meals, medication and total-exposure details remain unverified.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Original cointervention, adherence, exposure and intervention-deviation material. No new totals/repetition counts, cumulative-exposure calculations or dosing instructions.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original cointervention, adherence, exposure and intervention-deviation material. No new totals/repetition counts, cumulative-exposure calculations or dosing instructions."
    },
    {
      "item_id": "N27",
      "question_type": "Evidence condition",
      "question": "Are original safety cautions separate from actual harm collection?",
      "needed": "Harm definitions, collection, comparators and exposure denominators",
      "role": "Supplementary",
      "role_reason": "This condition connects Harm definitions, collection, comparators and exposure denominators with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for Harm definitions, collection, comparators and exposure denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Report-specific harm definitions, collection, severity, exposure/denominators, attrition and shared management. Do not turn original cautions into no-harm claims, new safety certification or treatment instructions. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Parent safety wording concerning milk-protein allergy and glucose-lowering medication/meal changes is original context. Actual allergy/hypoglycemia event counts, collection methods, arm-specific exposure denominators and CIs remain separately unverified.",
      "condition_status": "Unverified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Report-specific harm definitions, collection, severity, exposure/denominators, attrition and shared management. Do not turn original cautions into no-harm claims, new safety certification or treatment instructions.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Report-specific harm definitions, collection, severity, exposure/denominators, attrition and shared management. Do not turn original cautions into no-harm claims, new safety certification or treatment instructions."
    },
    {
      "item_id": "N28",
      "question_type": "Evidence condition",
      "question": "Are long-term/rare harms and post-intervention outcomes available?",
      "needed": "Short-term scope versus long-term/rare harms",
      "role": "Supplementary",
      "role_reason": "This condition connects Short-term scope versus long-term/rare harms with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for Short-term scope versus long-term/rare harms must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Actual long-term/harm follow-up, exposure duration, outcome-specific denominators and report links. Unread/unverified is not zero events or established safety. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Acute/7-day glucose signals and combination context do not establish long-term whey-only effects or rare allergy/hypoglycemia incidence.",
      "condition_status": "Unverified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Actual long-term/harm follow-up, exposure duration, outcome-specific denominators and report links. Unread/unverified is not zero events or established safety.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Actual long-term/harm follow-up, exposure duration, outcome-specific denominators and report links. Unread/unverified is not zero events or established safety."
    },
    {
      "item_id": "N29",
      "question_type": "Evidence condition",
      "question": "Which new materials would prompt an update to this table?",
      "needed": "Conditions, observations, original material and verdict-change events",
      "role": "Required",
      "role_reason": "This condition connects Separate conditions, observations, originals and verdict-change events with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for Separate conditions, observations, originals and verdict-change events must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Complete prechange preservation, original materials, condition versions, separate application and review records. No new searches, calculations, grades, independence certification, dosing instructions, medication changes or treatment guidance. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "This is a production table from stored material for short-term postprandial glucose. Rows and links can be updated after original papers, endpoints/times, denominators, actual comparators, shared reports and support/harm material are reviewed.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Complete prechange preservation, original materials, condition versions, separate application and review records. No new searches, calculations, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Complete prechange preservation, original materials, condition versions, separate application and review records. No new searches, calculations, grades, independence certification, dosing instructions, medication changes or treatment guidance."
    }
  ],
  "reports": [
    {
      "report_id": "R01",
      "title": "Jakubowicz D, Froy O, Ahrén B, et al. Incretin, insulinotropic and glucose-lowering effects of whey protein pre-load in type 2 diabetes: a randomised clinical trial. Diabetologia. 2014;57:1807-1811. PMID: 25005331. DOI: 10.1007/s00125-014-3305-x.",
      "url": "https://pubmed.ncbi.nlm.nih.gov/25005331/",
      "report_type": "Acute randomized crossover trial",
      "existence": "Report linked in the original parent stored summary evidence/citation lists. External public availability, access and current acquisition of the original are unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "study_family": "Acute whey-only report; independent replication unverified",
      "independent_replication": "Parent 2997 and both subclaim sheets share the context of the same three reports. Acute/7-day whey and MCT-plus-WPI combinations are not certified as independent replication of the same intervention. Reports, sheets, crossover periods, repeated measurements and subgroups are not summed into new trials or participants; unique-trial/participant totals, cohort relationships and independence are unverified.",
      "observed_result": "Glucose response 28% lower; insulin 105% higher",
      "result_level": "Acute report for the selected short-term question. Preserve original scope of 15 adults with type 2 diabetes, 50 g, 30 minutes before a meal and 180-minute response, with glucose 28% lower/insulin 105% higher. Exact GLP-1 values, glucose concentrations at specific times, direct effects/CIs, exact P values and denominators are unverified.",
      "source_evidence_date": "2026-09-07",
      "materials": [
        {
          "material_type": "Stored existing review summary",
          "public_status": "Preserved copy of the complete parent-verdict stored summary",
          "access_status": "Stored summary",
          "acquired": true,
          "actually_read": "Summary read",
          "as_of": "2026-09-07",
          "qualification": "Preserve the original PubMed URL, PMID 25005331, DOI 10.1007/s00125-014-3305-x and PMCID unrecorded. Distinguish evidence registration field NCT01571622 from unrecorded registration wording in the citation. No new URL, prospective registration status or actual reading is inferred from identifiers."
        },
        {
          "material_type": "External abstract",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": null,
          "qualification": "Preserve the original PubMed URL, PMID 25005331, DOI 10.1007/s00125-014-3305-x and PMCID unrecorded. Distinguish evidence registration field NCT01571622 from unrecorded registration wording in the citation. No new URL, prospective registration status or actual reading is inferred from identifiers."
        },
        {
          "material_type": "External full text",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": null,
          "qualification": "Preserve the original PubMed URL, PMID 25005331, DOI 10.1007/s00125-014-3305-x and PMCID unrecorded. Distinguish evidence registration field NCT01571622 from unrecorded registration wording in the citation. No new URL, prospective registration status or actual reading is inferred from identifiers."
        },
        {
          "material_type": "Registration material",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": null,
          "qualification": "Preserve the original PubMed URL, PMID 25005331, DOI 10.1007/s00125-014-3305-x and PMCID unrecorded. Distinguish evidence registration field NCT01571622 from unrecorded registration wording in the citation. No new URL, prospective registration status or actual reading is inferred from identifiers."
        },
        {
          "material_type": "Protocol and analysis plan",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": null,
          "qualification": "Preserve the original PubMed URL, PMID 25005331, DOI 10.1007/s00125-014-3305-x and PMCID unrecorded. Distinguish evidence registration field NCT01571622 from unrecorded registration wording in the citation. No new URL, prospective registration status or actual reading is inferred from identifiers."
        }
      ],
      "links": [
        {
          "label": "PubMed",
          "url": "https://pubmed.ncbi.nlm.nih.gov/25005331/"
        }
      ]
    },
    {
      "report_id": "R02",
      "title": "Smith K, Taylor GS, Allerton DM, et al. Thrice daily consumption of a novel, premeal shot containing a low dose of whey protein increases time in euglycemia during 7 days of free-living in individuals with type 2 diabetes. BMJ Open Diabetes Res Care. 2022;10:e002820. PMID: 35618446. PMCID: PMC9137348. DOI: 10.1136/bmjdrc-2022-002820.",
      "url": "https://pubmed.ncbi.nlm.nih.gov/35618446/",
      "report_type": "Seven-day free-living crossover trial",
      "existence": "Report linked in the original parent stored summary evidence/citation lists. External public availability, access and current acquisition of the original are unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "study_family": "7-day non-isocaloric whey-drink report; independent replication unverified",
      "independent_replication": "Parent 2997 and both subclaim sheets share the context of the same three reports. Acute/7-day whey and MCT-plus-WPI combinations are not certified as independent replication of the same intervention. Reports, sheets, crossover periods, repeated measurements and subgroups are not summed into new trials or participants; unique-trial/participant totals, cohort relationships and independence are unverified.",
      "observed_result": "iAUC 1.6±0.6 versus 2.1±0.9, P=.003",
      "result_level": "Separate 7-day free-living report for the selected short-term question. Distinguish 18 participants, a premeal 15.6 g protein drink and iAUC 1.6±0.6 versus 2.1±0.9/P=.003 from approximately 100 kcal versus 34 kcal calorie imbalance and the original registered/published primary-outcome mismatch. iAUC units, the meaning of ±, CIs, time-metric values and the exact mismatched endpoints are unverified.",
      "source_evidence_date": "2026-09-07",
      "materials": [
        {
          "material_type": "Stored existing review summary",
          "public_status": "Preserved copy of the complete parent-verdict stored summary",
          "access_status": "Stored summary",
          "acquired": true,
          "actually_read": "Summary read",
          "as_of": "2026-09-07",
          "qualification": "Preserve the original PubMed URL, PMID 35618446, DOI 10.1136/bmjdrc-2022-002820 and PMCID PMC9137348. Distinguish evidence registration field ISRCTN17563146 from unrecorded registration wording in the citation. No new URL, prospective registration status or actual reading is inferred from identifiers."
        },
        {
          "material_type": "External abstract",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": null,
          "qualification": "Preserve the original PubMed URL, PMID 35618446, DOI 10.1136/bmjdrc-2022-002820 and PMCID PMC9137348. Distinguish evidence registration field ISRCTN17563146 from unrecorded registration wording in the citation. No new URL, prospective registration status or actual reading is inferred from identifiers."
        },
        {
          "material_type": "External full text",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": null,
          "qualification": "Preserve the original PubMed URL, PMID 35618446, DOI 10.1136/bmjdrc-2022-002820 and PMCID PMC9137348. Distinguish evidence registration field ISRCTN17563146 from unrecorded registration wording in the citation. No new URL, prospective registration status or actual reading is inferred from identifiers."
        },
        {
          "material_type": "Registration material",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": null,
          "qualification": "Preserve the original PubMed URL, PMID 35618446, DOI 10.1136/bmjdrc-2022-002820 and PMCID PMC9137348. Distinguish evidence registration field ISRCTN17563146 from unrecorded registration wording in the citation. No new URL, prospective registration status or actual reading is inferred from identifiers."
        },
        {
          "material_type": "Protocol and analysis plan",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": null,
          "qualification": "Preserve the original PubMed URL, PMID 35618446, DOI 10.1136/bmjdrc-2022-002820 and PMCID PMC9137348. Distinguish evidence registration field ISRCTN17563146 from unrecorded registration wording in the citation. No new URL, prospective registration status or actual reading is inferred from identifiers."
        }
      ],
      "links": [
        {
          "label": "PubMed",
          "url": "https://pubmed.ncbi.nlm.nih.gov/35618446/"
        }
      ]
    },
    {
      "report_id": "R03",
      "title": "Zameer R, et al. Effect of medium-chain triglycerides and whey protein isolate preloads on glycaemia in type 2 diabetes: a randomized crossover study. Am J Clin Nutr. 2025. PMID: 39732398. PMCID: PMC11863336. DOI: 10.1016/j.ajcnut.2024.12.022.",
      "url": "https://pubmed.ncbi.nlm.nih.gov/39732398/",
      "report_type": "Randomized MCT-plus-WPI crossover trial",
      "existence": "Report linked in the original parent stored summary evidence/citation lists. External public availability, access and current acquisition of the original are unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "study_family": "MCT-plus-WPI combination report; not whey alone",
      "independent_replication": "Parent 2997 and both subclaim sheets share the context of the same three reports. Acute/7-day whey and MCT-plus-WPI combinations are not certified as independent replication of the same intervention. Reports, sheets, crossover periods, repeated measurements and subgroups are not summed into new trials or participants; unique-trial/participant totals, cohort relationships and independence are unverified.",
      "observed_result": "Primary iAUC outcomes were null",
      "result_level": "Background report of an MCT-plus-WPI combination. Preserve null primary 24-hour/daytime glucose iAUC without turning it into the same whey-only comparison, zero effect, equivalence or a long-term whey-only conclusion. Exact sample size, intervention duration, effects/CIs, P values and denominators are unverified.",
      "source_evidence_date": "2026-09-07",
      "materials": [
        {
          "material_type": "Stored existing review summary",
          "public_status": "Preserved copy of the complete parent-verdict stored summary",
          "access_status": "Stored summary",
          "acquired": true,
          "actually_read": "Summary read",
          "as_of": "2026-09-07",
          "qualification": "Preserve the original PubMed URL, PMID 39732398, DOI 10.1016/j.ajcnut.2024.12.022 and PMCID PMC11863336. Distinguish evidence registration field NCT04905589 from unrecorded registration wording in the citation. No new URL, prospective registration status or actual reading is inferred from identifiers."
        },
        {
          "material_type": "External abstract",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": null,
          "qualification": "Preserve the original PubMed URL, PMID 39732398, DOI 10.1016/j.ajcnut.2024.12.022 and PMCID PMC11863336. Distinguish evidence registration field NCT04905589 from unrecorded registration wording in the citation. No new URL, prospective registration status or actual reading is inferred from identifiers."
        },
        {
          "material_type": "External full text",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": null,
          "qualification": "Preserve the original PubMed URL, PMID 39732398, DOI 10.1016/j.ajcnut.2024.12.022 and PMCID PMC11863336. Distinguish evidence registration field NCT04905589 from unrecorded registration wording in the citation. No new URL, prospective registration status or actual reading is inferred from identifiers."
        },
        {
          "material_type": "Registration material",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": null,
          "qualification": "Preserve the original PubMed URL, PMID 39732398, DOI 10.1016/j.ajcnut.2024.12.022 and PMCID PMC11863336. Distinguish evidence registration field NCT04905589 from unrecorded registration wording in the citation. No new URL, prospective registration status or actual reading is inferred from identifiers."
        },
        {
          "material_type": "Protocol and analysis plan",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": null,
          "qualification": "Preserve the original PubMed URL, PMID 39732398, DOI 10.1016/j.ajcnut.2024.12.022 and PMCID PMC11863336. Distinguish evidence registration field NCT04905589 from unrecorded registration wording in the citation. No new URL, prospective registration status or actual reading is inferred from identifiers."
        }
      ],
      "links": [
        {
          "label": "PubMed",
          "url": "https://pubmed.ncbi.nlm.nih.gov/39732398/"
        }
      ]
    }
  ],
  "method_sources": [
    {
      "id": "M03",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03",
      "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13",
      "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M04",
      "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04",
      "section": "§4.5, §4.6.1–4.6.3, MECIR C42",
      "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M08",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08",
      "section": "§8.1–8.2.3, Table 8.2.a",
      "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M15",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15",
      "section": "§15.2.4, §15.3.1–15.3.3",
      "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M19",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19",
      "section": "§19.1.2, §19.2.1–19.2.4",
      "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    }
  ],
  "status_dictionary": {
    "Partly verified": "Some information is present in the stored source, with detailed original materials still unverified; this does not mean review passed or clinical efficacy certified",
    "Unverified": "Detailed materials for the selected condition could not be established within the stored scope; this does not mean zero effect, zero studies or safety",
    "Review incomplete": "Awaiting user review",
    "Met": "Use only within the relevant condition's scope after user review; no automatic display in this preparation",
    "Not reported": "Distinguish only within materials actually read; do not turn unread external materials into unreported findings",
    "Inaccessible": "Not applied during this preparation because actual access was not tested",
    "Not applicable": "Use with a reason for non-applicability based on an explicit question boundary",
    "Conflicting data": "Judge after actual material comparison; review was not performed during this preparation",
    "Insufficient evidence for the conditions": "Do not use as a clinical grade encompassing currently unread materials"
  },
  "study_overlap": {
    "state": "Unverified",
    "unique_trial_count": null,
    "unique_participant_count": null,
    "reason": "Parent 2997 and both subclaim sheets share the context of the same three reports. Acute/7-day whey and MCT-plus-WPI combinations are not certified as independent replication of the same intervention. Reports, sheets, crossover periods, repeated measurements and subgroups are not summed into new trials or participants; unique-trial/participant totals, cohort relationships and independence are unverified."
  },
  "history": [
    {
      "date": "2026-10-16",
      "kind": "Separation of public-facing pages and materials",
      "view_version": "1.0",
      "change": "Public pages and materials were created from the existing 29 items. No new clinical search, verification-status change or scoring was performed."
    }
  ],
  "language": "en",
  "translation_date": "2026-10-16"
}