{
  "schema_version": "chamgap-public-criteria-1.0",
  "title": "Whey protein preload × acute or several-day postprandial glucose",
  "language": "en",
  "translation_date": "2026-10-16",
  "criteria_version": "1.0",
  "criteria_date": "2026-10-06",
  "condition_origin": "Chamgap's own application conditions",
  "method_sources": [
    {
      "id": "M03",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03",
      "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13",
      "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M04",
      "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04",
      "section": "§4.5, §4.6.1–4.6.3, MECIR C42",
      "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M08",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08",
      "section": "§8.1–8.2.3, Table 8.2.a",
      "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M15",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15",
      "section": "§15.2.4, §15.3.1–15.3.3",
      "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M19",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19",
      "section": "§19.1.2, §19.2.1–19.2.4",
      "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    }
  ],
  "status_dictionary": {
    "Partly verified": "Some information is present in the stored source, with detailed original materials still unverified; this does not mean review passed or clinical efficacy certified",
    "Unverified": "Detailed materials for the selected condition could not be established within the stored scope; this does not mean zero effect, zero studies or safety",
    "Review incomplete": "Awaiting user review",
    "Met": "Use only within the relevant condition's scope after user review; no automatic display in this preparation",
    "Not reported": "Distinguish only within materials actually read; do not turn unread external materials into unreported findings",
    "Inaccessible": "Not applied during this preparation because actual access was not tested",
    "Not applicable": "Use with a reason for non-applicability based on an explicit question boundary",
    "Conflicting data": "Judge after actual material comparison; review was not performed during this preparation",
    "Insufficient evidence for the conditions": "Do not use as a clinical grade encompassing currently unread materials"
  },
  "requirements": [
    {
      "item_id": "N01",
      "question_type": "Evidence condition",
      "question": "Which short-term glucose claim is being checked?",
      "needed": "Selected acute or several-day postprandial glucose claim",
      "role": "Required",
      "role_reason": "This condition connects Selected acute or several-day postprandial glucose claim with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for Selected acute or several-day postprandial glucose claim must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Material for the selected question's postprandial measures, times, direct comparisons and populations, plus boundary review. Do not fill the subclaim score from its parent. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N02",
      "question_type": "Evidence condition",
      "question": "What did the acute 15-person trial report for glucose?",
      "needed": "Original estimate of 180-minute glucose response",
      "role": "Required",
      "role_reason": "This condition connects Original estimate of 180-minute glucose response with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for Original estimate of 180-minute glucose response must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: The definition of the 180-minute response, original curves/measures, direct comparator, absolute effect/CI, exact P value and analysis denominator. No new absolute effect or numerical example is calculated from 28%. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N03",
      "question_type": "Evidence condition",
      "question": "Are insulin and GLP-1 the same outcomes as glucose or complications?",
      "needed": "Separate mechanistic hormones from postprandial glucose",
      "role": "Required",
      "role_reason": "This condition connects Separate mechanistic hormones from postprandial glucose with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for Separate mechanistic hormones from postprandial glucose must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Each hormone's times, denominators, effects/CIs and actual clinical outcomes. Do not transfer 105% into glucose reduction or complication prevention. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N04",
      "question_type": "Evidence condition",
      "question": "What was the 7-day free-living iAUC result?",
      "needed": "Smith's 7-day postprandial glucose iAUC",
      "role": "Required",
      "role_reason": "This condition connects Smith's 7-day postprandial glucose iAUC with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for Smith's 7-day postprandial glucose iAUC must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: iAUC units/baseline, curve interval, analysis, direct between-condition CI, the type of ± statistic, period-specific denominators and missing data. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N05",
      "question_type": "Evidence condition",
      "question": "Are time above range and iAUC distinct outcomes?",
      "needed": "Separate time above range, time in euglycemia and postprandial iAUC",
      "role": "Required",
      "role_reason": "This condition connects Separate time above range, time in euglycemia and postprandial iAUC with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for Separate time above range, time in euglycemia and postprandial iAUC must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Definitions of high/normal glucose ranges, valid CGM time, missing data, outcome-specific effects/CIs and prespecified hierarchy. Do not copy iAUC P=.003 to other time metrics. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N06",
      "question_type": "Evidence condition",
      "question": "Are acute 180-minute and 7-day measures the same time point?",
      "needed": "Time boundaries for one-meal response and several-day free-living exposure",
      "role": "Required",
      "role_reason": "This condition connects Time boundaries for one-meal response and several-day free-living exposure with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for Time boundaries for one-meal response and several-day free-living exposure must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Report-specific time origins, meal/measurement windows, repeats, period-specific analysis denominators and post-intervention material. Do not turn short-term reduction into long-term HbA1c benefit. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N07",
      "question_type": "Evidence condition",
      "question": "Were the formulation and protein amount the same?",
      "needed": "Acute 50 g whey and a 15.6 g protein drink",
      "role": "Required",
      "role_reason": "This condition connects Acute 50 g whey and a 15.6 g protein drink with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for Acute 50 g whey and a 15.6 g protein drink must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Report-specific product/ingredient, protein content, manufacturing/formulation, comparator and actual exposure material. No new dose/total calculations or dosing instructions. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N08",
      "question_type": "Evidence condition",
      "question": "Was the 7-day comparator isocaloric?",
      "needed": "Calories and nutritional composition of test/control drinks",
      "role": "Required",
      "role_reason": "This condition connects Calories and nutritional composition of test/control drinks with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for Calories and nutritional composition of test/control drinks must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Test/control composition, calories, taste/blinding, meal compensation, total intake and activity changes. No new calorie difference or cumulative calories are calculated. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N09",
      "question_type": "Evidence condition",
      "question": "Are preload timing and meal conditions linked?",
      "needed": "Preload timing and meal/comparator conditions",
      "role": "Required",
      "role_reason": "This condition connects Preload timing and meal/comparator conditions with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for Preload timing and meal/comparator conditions must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Report-specific meal/preload times, meal composition, control procedures, measurement and adherence source material. Preserve research identifiers without creating an intake sequence or dosing instructions. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N10",
      "question_type": "Evidence condition",
      "question": "Were participants and glucose-lowering medications comparable?",
      "needed": "Type 2 diabetes and non-insulin-treated population boundaries",
      "role": "Required",
      "role_reason": "This condition connects Type 2 diabetes and non-insulin-treated population boundaries with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for Type 2 diabetes and non-insulin-treated population boundaries must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Report-specific eligibility, baseline characteristics and medication/meal cointerventions. Do not establish effects in insulin-treated or other populations, or give medication-change instructions. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N11",
      "question_type": "Evidence condition",
      "question": "Are original crossover denominators and period effects known?",
      "needed": "Crossover design, repeated measurements and denominators for 15/18 participants",
      "role": "Required",
      "role_reason": "This condition connects Crossover design, repeated measurements and denominators for 15/18 participants with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for Crossover design, repeated measurements and denominators for 15/18 participants must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Allocation sequence, period-specific analysis populations, attrition, repeated-measures models and missing-measurement source material. Do not count repeats in the same people as new participants or independent trials. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N12",
      "question_type": "Evidence condition",
      "question": "Did registered and published primary outcomes agree?",
      "needed": "Historical Smith registered/published outcome-hierarchy mismatch",
      "role": "Required",
      "role_reason": "This condition connects Historical Smith registered/published outcome-hierarchy mismatch with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for Historical Smith registered/published outcome-hierarchy mismatch must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Registration dates/change history, protocol/SAP, original published outcome wording and the exact mismatch. Preserve the historical mismatch without new registry verification or regrading. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N13",
      "question_type": "Evidence condition",
      "question": "Is null primary iAUC for MCT plus WPI a whey-only result?",
      "needed": "24-hour/daytime endpoints of combined MCT plus WPI",
      "role": "Required",
      "role_reason": "This condition connects 24-hour/daytime endpoints of combined MCT plus WPI with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for 24-hour/daytime endpoints of combined MCT plus WPI must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Product/components, comparator, duration, population/denominators, each primary iAUC effect/CI and exact P value. Null findings do not create equivalence, zero effect or a whey-only conclusion. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N14",
      "question_type": "Evidence condition",
      "question": "Is the longer whey-plus-guar report identified?",
      "needed": "Combined long-term material versus whey-only/report identification",
      "role": "Required",
      "role_reason": "This condition connects Combined long-term material versus whey-only/report identification with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for Combined long-term material versus whey-only/report identification must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: The original guar-combination bibliography, components, duration, results, denominators and isolated contribution. Do not create trial, participant or effect numbers for an unidentified report. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N15",
      "question_type": "Evidence condition",
      "question": "Do short-term glucose findings establish long-term HbA1c or complications?",
      "needed": "Postprandial surrogates, long-term whey-only benefit and medication-replacement boundaries",
      "role": "Required",
      "role_reason": "This condition connects Postprandial surrogates, long-term whey-only benefit and medication-replacement boundaries with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for Postprandial surrogates, long-term whey-only benefit and medication-replacement boundaries must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Direct long-term whey-only HbA1c, clinical-complication and medication outcomes, comparisons/CIs and denominators. No new diabetes-treatment/medication-replacement conclusions or instructions. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N16",
      "question_type": "Evidence condition",
      "question": "Do unverified effects/CIs and statistical units remain explicit?",
      "needed": "Distinguish relative response, iAUC, ± values and denominators",
      "role": "Required",
      "role_reason": "This condition connects Distinguish relative response, iAUC, ± values and denominators with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for Distinguish relative response, iAUC, ± values and denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original tables, models, units, variance definitions, CIs and measurement times/denominators for each outcome. No invented numbers, new effects/intervals or unit conversions. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N17",
      "question_type": "Evidence condition",
      "question": "Does the same direction establish strict independent replication?",
      "needed": "Short-term designs, industry involvement and combination differences",
      "role": "Required",
      "role_reason": "This condition connects Short-term designs, industry involvement and combination differences with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for Short-term designs, industry involvement and combination differences must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Independent studies addressing the same question, formulation, calories/comparator, population and prespecified outcomes, plus funding/analysis roles. No new pooled effect, unique-trial count or participant total. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N18",
      "question_type": "Evidence condition",
      "question": "Are shared reports/populations counted as new independent trials?",
      "needed": "Shared parent, subclaim, report and cohort relationships",
      "role": "Required",
      "role_reason": "This condition connects Shared parent, subclaim, report and cohort relationships with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for Shared parent, subclaim, report and cohort relationships must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original study/report identities, cohorts and analysis-population links. Unique-trial and unique-participant totals are unverified. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N19",
      "question_type": "Evidence condition",
      "question": "Which materials were actually read?",
      "needed": "Stored parent summary versus external access",
      "role": "Required",
      "role_reason": "This condition connects Stored parent summary versus external access with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for Stored parent summary versus external access must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Actually acquired original papers, supplements, registration/plans and reading records. No separate external link/screen tests or new lookup. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N20",
      "question_type": "Evidence condition",
      "question": "Where are original bibliography and registry identifiers recorded?",
      "needed": "Evidence registration field versus citation bibliography",
      "role": "Required",
      "role_reason": "This condition connects Evidence registration field versus citation bibliography with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for Evidence registration field versus citation bibliography must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Paper-registry identity, dates and content. A registration identifier does not prove prospective status or actual reading. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N21",
      "question_type": "Evidence condition",
      "question": "What is the scope of historical verification wording?",
      "needed": "Original Korean/English, subclaim notes and historical cross-check wording",
      "role": "Required",
      "role_reason": "This condition connects Original Korean/English, subclaim notes and historical cross-check wording with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for Original Korean/English, subclaim notes and historical cross-check wording must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Review of originals, translation and corrections. Do not label historical verification as a new completed clinical review or independent clinical validation. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N22",
      "question_type": "Evidence condition",
      "question": "Are selected-subclaim values separate from parent score and axes?",
      "needed": "Original subclaim grade/note, absent score/status and parent context",
      "role": "Required",
      "role_reason": "This condition connects Original subclaim grade/note, absent score/status and parent context with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for Original subclaim grade/note, absent score/status and parent context must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Review of the selected question, original values and parent boundary. No new scores, axes, efficacy grades or verdict changes. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N23",
      "question_type": "Evidence condition",
      "question": "What are the original evidence date and empty correction history?",
      "needed": "Separate evidence date, corrections and production date",
      "role": "Required",
      "role_reason": "This condition connects Separate evidence date, corrections and production date with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for Separate evidence date, corrections and production date must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Actual corrections/follow-up material and original/change records when acquired. Existing wording and dates are preserved. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N24",
      "question_type": "Evidence condition",
      "question": "Are funding, product support, employee authors and analysis roles distinguished?",
      "needed": "Four report-specific industry/support aspects",
      "role": "Required",
      "role_reason": "This condition connects Four report-specific industry/support aspects with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for Four report-specific industry/support aspects must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Each report's original funding, product/device support, author affiliations and analysis/publication roles. Do not upgrade parent independence axes into new certification. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N25",
      "question_type": "Evidence condition",
      "question": "Are allocation, blinding, measurement and selective reporting known?",
      "needed": "Original study designs and detailed bias conditions",
      "role": "Required",
      "role_reason": "This condition connects Original study designs and detailed bias conditions with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for Original study designs and detailed bias conditions must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Methods, registration/protocol/SAP, original analysis tables and change history. A design label does not establish official RoB/GRADE certification or completed review. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N26",
      "question_type": "Evidence condition",
      "question": "Are adherence, cointerventions and actual exposure preserved?",
      "needed": "Actual intervention, control and shared management by report",
      "role": "Required",
      "role_reason": "This condition connects Actual intervention, control and shared management by report with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for Actual intervention, control and shared management by report must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original cointervention, adherence, exposure and intervention-deviation material. No new totals/repetition counts, cumulative-exposure calculations or dosing instructions. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N27",
      "question_type": "Evidence condition",
      "question": "Are original safety cautions separate from actual harm collection?",
      "needed": "Harm definitions, collection, comparators and exposure denominators",
      "role": "Supplementary",
      "role_reason": "This condition connects Harm definitions, collection, comparators and exposure denominators with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for Harm definitions, collection, comparators and exposure denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Report-specific harm definitions, collection, severity, exposure/denominators, attrition and shared management. Do not turn original cautions into no-harm claims, new safety certification or treatment instructions. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N28",
      "question_type": "Evidence condition",
      "question": "Are long-term/rare harms and post-intervention outcomes available?",
      "needed": "Short-term scope versus long-term/rare harms",
      "role": "Supplementary",
      "role_reason": "This condition connects Short-term scope versus long-term/rare harms with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for Short-term scope versus long-term/rare harms must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Actual long-term/harm follow-up, exposure duration, outcome-specific denominators and report links. Unread/unverified is not zero events or established safety. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N29",
      "question_type": "Evidence condition",
      "question": "Which new materials would prompt an update to this table?",
      "needed": "Conditions, observations, original material and verdict-change events",
      "role": "Required",
      "role_reason": "This condition connects Separate conditions, observations, originals and verdict-change events with short-term postprandial glucose for whey, report-specific populations and denominators, acute versus several-day exposure, comparator calories, glucose versus hormones, outcome hierarchy, combinations, support and harms.",
      "application_exception": "Preserve original subclaim C, the two-small-study positive-signal note and absent score, status and axes. Distinguish acute 180-minute and 7-day exposure, 28% lower glucose versus 105% higher insulin, and iAUC versus time metrics. Retain calorie imbalance, outcome-hierarchy mismatch, combinations, industry involvement and unverified details; create no new effects, CIs, totals, grades, independence certification, dosing instructions, medication changes or treatment guidance.",
      "criterion": "Material for Separate conditions, observations, originals and verdict-change events must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Complete prechange preservation, original materials, condition versions, separate application and review records. No new searches, calculations, grades, independence certification, dosing instructions, medication changes or treatment guidance. This records needed materials; no new research was executed."
    }
  ]
}