{
  "schema_version": "chamgap-public-evidence-check-1.0",
  "public_id": "v2995-s1",
  "verdict_number": "2995",
  "title": "Static standing × long-term HbA1c or diabetes complications",
  "view_version": "1.0",
  "view_created_date": "2026-10-16",
  "criteria_version": "1.0",
  "criteria_date": "2026-10-06",
  "review_date": null,
  "legacy_evidence_date": "2026-09-07",
  "review_scope": {
    "materials_read": "Existing review summaries and stored records of methodological application",
    "clinical_papers_directly_read": false,
    "new_clinical_search": false,
    "limitation": "Existing stored summary and preserved methodology application records. External papers, abstracts, registration, protocols, SAPs, original result tables and support disclosures are unread, and review of existing content remains incomplete.",
    "date_meaning": "This is the date the stored materials were checked, not the date of a new search of the clinical literature."
  },
  "claim_context": {
    "population": "The positive Henson sample comprised 22 overweight or obese postmenopausal women with dysglycemia. The related Yates analysis of 60 participants concerns a different older population, described bibliographically as South Asians and White Europeans. Exact eligibility, ages, baseline values and condition-specific denominators are unverified; findings are not extended to everyone with established diabetes.",
    "intervention": "The original research exposure was motionless static standing for five minutes every 30 minutes during a 7.5-hour day. It is distinguished from walking and the eight-week height-adjustable-desk question. The research record is not turned into personal standing/exercise instructions or a prescription.",
    "dose": "Preserve only the original recorded total of 60 minutes per day. Actual condition-specific adherence, movement, meals and concurrent activity are unverified. No frequency, total exposure, dose conversion or new schedule is calculated.",
    "comparator": "The direct comparator was uninterrupted sitting. Walking is a different activity condition and its effects are not transferred to standing. A nonsignificant walking-versus-standing contrast does not prove equivalence. Details of condition-specific direct contrasts, order, washout and concurrent management are unverified.",
    "endpoint": "The selected question is improved long-term HbA1c or diabetes complications; preserve original grade ? and the note that the acute trials did not measure these outcomes. HbA1c values/between-group changes and complication-specific event definitions, time at risk, denominators, effects and CIs are unverified. First-day glucose/insulin iAUC is not converted into direct long-term results, and nonmeasurement is not changed into zero effects, zero events or absence of all long-term research.",
    "duration": "The original reports concern a single 7.5-hour laboratory day and some next-day metabolic endpoints. Actual follow-up, long-term exposure, sustained adherence and medication/diet changes for long-term HbA1c or complications are unverified. Null next-day findings or mention of an eight-week desk study are not made into direct results for this long-term question.",
    "excluded_extensions": [
      "Changing original grade ? or acute nonmeasurement into a zero score, no effect, zero events or absence of all long-term research",
      "Transferring first-day glucose/insulin iAUC, null next-day insulin or null acute Yates results into long-term HbA1c/complication effects",
      "Extending selected postmenopausal women with dysglycemia or another older population to everyone receiving treatment for established diabetes",
      "Substituting walking or the eight-week desk question for direct long-term static-standing evidence or certifying nonsignificance as equivalence",
      "Summing 22 acute participants, 60 analyzed or crossover conditions into long-term analysis/event denominators, time at risk or independent-trial totals",
      "Inheriting parent C54/Unknown, I2, registered-primary wording or historical checks as absent subclaim values, current review, prospective status or independence certification",
      "Creating new absolute differences, CIs, exposure totals, standing/exercise instructions, medication changes or diabetes treatment guidance"
    ]
  },
  "requirements": [
    {
      "item_id": "N01",
      "question_type": "Evidence condition",
      "question": "Which long-term claim is being checked?",
      "needed": "Separate direct questions about long-term HbA1c and diabetes complications",
      "role": "Required",
      "role_reason": "This condition connects Separate direct questions about long-term HbA1c and diabetes complications with separate direct questions about long-term HbA1c and diabetes complications, the scope of acute materials, populations, static standing versus walking, comparators, denominators, cointerventions, registration, support and harms.",
      "application_exception": "Retain original grade ?, nonmeasurement of long-term outcomes and absent subclaim score, safety and axes. Positive first-day glucose/insulin iAUC, null next-day insulin and null acute Yates results are not direct long-term effects. Distinguish registered AUC/reported iAUC, the unverified meaning of ±, populations and condition-specific denominators, walking and the eight-week desk question. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, standing/exercise instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Separate direct questions about long-term HbA1c and diabetes complications must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Materials identifying long-term HbA1c and complications as separate direct questions, with claim-boundary checks. The ? is not changed into a zero score or no effect. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The existing subclaim is improved long-term HbA1c or diabetes complications, originally graded ?, with a note that the acute trials did not measure these outcomes. Subclaim score, safety and axes are unrecorded and distinct from parent same-day C54.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Materials identifying long-term HbA1c and complications as separate direct questions, with claim-boundary checks. The ? is not changed into a zero score or no effect.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Materials identifying long-term HbA1c and complications as separate direct questions, with claim-boundary checks. The ? is not changed into a zero score or no effect."
    },
    {
      "item_id": "N02",
      "question_type": "Evidence condition",
      "question": "Was long-term HbA1c measured directly?",
      "needed": "Long-term HbA1c results for static standing",
      "role": "Required",
      "role_reason": "This condition connects Long-term HbA1c results for static standing with separate direct questions about long-term HbA1c and diabetes complications, the scope of acute materials, populations, static standing versus walking, comparators, denominators, cointerventions, registration, support and harms.",
      "application_exception": "Retain original grade ?, nonmeasurement of long-term outcomes and absent subclaim score, safety and axes. Positive first-day glucose/insulin iAUC, null next-day insulin and null acute Yates results are not direct long-term effects. Distinguish registered AUC/reported iAUC, the unverified meaning of ±, populations and condition-specific denominators, walking and the eight-week desk question. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, standing/exercise instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Long-term HbA1c results for static standing must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Long-term HbA1c values/changes, timing, comparator, denominators, CIs and medication/diet cointerventions. Nonmeasurement is not changed into zero effect. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The original note records that the acute trials did not measure long-term outcomes. Same-day glucose iAUC and insulin values are not HbA1c values, between-group changes or CIs.",
      "condition_status": "Unverified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Long-term HbA1c values/changes, timing, comparator, denominators, CIs and medication/diet cointerventions. Nonmeasurement is not changed into zero effect.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Long-term HbA1c values/changes, timing, comparator, denominators, CIs and medication/diet cointerventions. Nonmeasurement is not changed into zero effect."
    },
    {
      "item_id": "N03",
      "question_type": "Evidence condition",
      "question": "Were diabetes complications measured directly?",
      "needed": "Complication types, event definitions and direct comparisons",
      "role": "Required",
      "role_reason": "This condition connects Complication types, event definitions and direct comparisons with separate direct questions about long-term HbA1c and diabetes complications, the scope of acute materials, populations, static standing versus walking, comparators, denominators, cointerventions, registration, support and harms.",
      "application_exception": "Retain original grade ?, nonmeasurement of long-term outcomes and absent subclaim score, safety and axes. Positive first-day glucose/insulin iAUC, null next-day insulin and null acute Yates results are not direct long-term effects. Distinguish registered AUC/reported iAUC, the unverified meaning of ±, populations and condition-specific denominators, walking and the eight-week desk question. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, standing/exercise instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Complication types, event definitions and direct comparisons must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Complication-specific definitions, event assessment/collection, long-term follow-up, group-specific events/denominators, effects and CIs. Unverified findings are not changed into zero events or zero preventive effects. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The original acute trials are recorded as not measuring these long-term outcomes. Complication types, group-specific event counts, time at risk, between-group effects and CIs are not established by the preserved material.",
      "condition_status": "Unverified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Complication-specific definitions, event assessment/collection, long-term follow-up, group-specific events/denominators, effects and CIs. Unverified findings are not changed into zero events or zero preventive effects.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Complication-specific definitions, event assessment/collection, long-term follow-up, group-specific events/denominators, effects and CIs. Unverified findings are not changed into zero events or zero preventive effects."
    },
    {
      "item_id": "N04",
      "question_type": "Evidence condition",
      "question": "Is first-day glucose iAUC a long-term treatment effect?",
      "needed": "Acute glucose surrogate versus direct long-term evidence",
      "role": "Required",
      "role_reason": "This condition connects Acute glucose surrogate versus direct long-term evidence with separate direct questions about long-term HbA1c and diabetes complications, the scope of acute materials, populations, static standing versus walking, comparators, denominators, cointerventions, registration, support and harms.",
      "application_exception": "Retain original grade ?, nonmeasurement of long-term outcomes and absent subclaim score, safety and axes. Positive first-day glucose/insulin iAUC, null next-day insulin and null acute Yates results are not direct long-term effects. Distinguish registered AUC/reported iAUC, the unverified meaning of ±, populations and condition-specific denominators, walking and the eight-week desk question. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, standing/exercise instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Acute glucose surrogate versus direct long-term evidence must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Direct materials linking acute responses and long-term endpoints, long-term intervention comparisons, the meaning of ± and direct CIs. No new effect/risk calculations or hypothetical numerical examples are created. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Henson first-day glucose iAUC was 5.3±0.8 with sitting versus 3.5±0.8 mmol/L·h with standing, P=.022, originally −34%. These are acute values, not conversions into long-term HbA1c, diabetes treatment or complication-risk reduction.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Direct materials linking acute responses and long-term endpoints, long-term intervention comparisons, the meaning of ± and direct CIs. No new effect/risk calculations or hypothetical numerical examples are created.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Direct materials linking acute responses and long-term endpoints, long-term intervention comparisons, the meaning of ± and direct CIs. No new effect/risk calculations or hypothetical numerical examples are created."
    },
    {
      "item_id": "N05",
      "question_type": "Evidence condition",
      "question": "Is insulin change a direct complication result?",
      "needed": "Distinguishing insulin responses, glucose and long-term clinical outcomes",
      "role": "Required",
      "role_reason": "This condition connects Distinguishing insulin responses, glucose and long-term clinical outcomes with separate direct questions about long-term HbA1c and diabetes complications, the scope of acute materials, populations, static standing versus walking, comparators, denominators, cointerventions, registration, support and harms.",
      "application_exception": "Retain original grade ?, nonmeasurement of long-term outcomes and absent subclaim score, safety and axes. Positive first-day glucose/insulin iAUC, null next-day insulin and null acute Yates results are not direct long-term effects. Distinguish registered AUC/reported iAUC, the unverified meaning of ±, populations and condition-specific denominators, walking and the eight-week desk question. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, standing/exercise instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Distinguishing insulin responses, glucose and long-term clinical outcomes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original insulin-endpoint definition, meaning of ±, direct CIs and long-term clinical materials. The same effect/P is not copied across different endpoints. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Henson first-day insulin iAUC was 548.2±71.8 versus 437.2±73.5 mU/L·h, P=.045, originally −20%. It is a postprandial metabolic measure, not a direct replacement for glucose endpoints, HbA1c or complication events.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Original insulin-endpoint definition, meaning of ±, direct CIs and long-term clinical materials. The same effect/P is not copied across different endpoints.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original insulin-endpoint definition, meaning of ±, direct CIs and long-term clinical materials. The same effect/P is not copied across different endpoints."
    },
    {
      "item_id": "N06",
      "question_type": "Evidence condition",
      "question": "Does a null next-day result establish a null long-term effect?",
      "needed": "Separating first-day, next-day and long-term findings",
      "role": "Required",
      "role_reason": "This condition connects Separating first-day, next-day and long-term findings with separate direct questions about long-term HbA1c and diabetes complications, the scope of acute materials, populations, static standing versus walking, comparators, denominators, cointerventions, registration, support and harms.",
      "application_exception": "Retain original grade ?, nonmeasurement of long-term outcomes and absent subclaim score, safety and axes. Positive first-day glucose/insulin iAUC, null next-day insulin and null acute Yates results are not direct long-term effects. Distinguish registered AUC/reported iAUC, the unverified meaning of ±, populations and condition-specific denominators, walking and the eight-week desk question. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, standing/exercise instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Separating first-day, next-day and long-term findings must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original day-specific findings, timing, denominators, direct effects/CIs and long-term follow-up for each endpoint. Short-term null findings are not transferred into zero long-term effects. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The original account records a null next-day insulin difference. This is not a test of long-term HbA1c or complications; exact next-day glucose findings are separately unverified.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Original day-specific findings, timing, denominators, direct effects/CIs and long-term follow-up for each endpoint. Short-term null findings are not transferred into zero long-term effects.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original day-specific findings, timing, denominators, direct effects/CIs and long-term follow-up for each endpoint. Short-term null findings are not transferred into zero long-term effects."
    },
    {
      "item_id": "N07",
      "question_type": "Evidence condition",
      "question": "Is the Yates standing-only null result a long-term outcome?",
      "needed": "Acute primary insulin/glucose versus long-term endpoints",
      "role": "Required",
      "role_reason": "This condition connects Acute primary insulin/glucose versus long-term endpoints with separate direct questions about long-term HbA1c and diabetes complications, the scope of acute materials, populations, static standing versus walking, comparators, denominators, cointerventions, registration, support and harms.",
      "application_exception": "Retain original grade ?, nonmeasurement of long-term outcomes and absent subclaim score, safety and axes. Positive first-day glucose/insulin iAUC, null next-day insulin and null acute Yates results are not direct long-term effects. Distinguish registered AUC/reported iAUC, the unverified meaning of ±, populations and condition-specific denominators, walking and the eight-week desk question. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, standing/exercise instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Acute primary insulin/glucose versus long-term endpoints must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Actual studies of direct long-term endpoints and original acute analysis tables/CIs. Null findings do not establish equivalence, zero effect or absence of all long-term research. This records needed materials; no new research was executed.",
      "current_reports": [
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The Yates acute crossover trial with 60 analyzed records null standing-versus-uninterrupted-sitting findings for primary insulin and glucose. This is not changed into a direct null study of long-term HbA1c or complications.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Actual studies of direct long-term endpoints and original acute analysis tables/CIs. Null findings do not establish equivalence, zero effect or absence of all long-term research.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Actual studies of direct long-term endpoints and original acute analysis tables/CIs. Null findings do not establish equivalence, zero effect or absence of all long-term research."
    },
    {
      "item_id": "N08",
      "question_type": "Evidence condition",
      "question": "Can the selected population represent everyone with established diabetes?",
      "needed": "Postmenopausal women with dysglycemia versus long-term target populations",
      "role": "Required",
      "role_reason": "This condition connects Postmenopausal women with dysglycemia versus long-term target populations with separate direct questions about long-term HbA1c and diabetes complications, the scope of acute materials, populations, static standing versus walking, comparators, denominators, cointerventions, registration, support and harms.",
      "application_exception": "Retain original grade ?, nonmeasurement of long-term outcomes and absent subclaim score, safety and axes. Positive first-day glucose/insulin iAUC, null next-day insulin and null acute Yates results are not direct long-term effects. Distinguish registered AUC/reported iAUC, the unverified meaning of ±, populations and condition-specific denominators, walking and the eight-week desk question. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, standing/exercise instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Postmenopausal women with dysglycemia versus long-term target populations must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Diagnostic criteria, medications, baseline HbA1c, disease/complications, eligibility and baseline risk for the long-term question. Original population boundaries are retained. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The positive sample was 22 overweight or obese postmenopausal women with dysglycemia, not everyone with established diabetes. The related older-adult trial also concerns a different population. Findings are not extended into treatment of all diabetes or disease prevention.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Diagnostic criteria, medications, baseline HbA1c, disease/complications, eligibility and baseline risk for the long-term question. Original population boundaries are retained.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Diagnostic criteria, medications, baseline HbA1c, disease/complications, eligibility and baseline risk for the long-term question. Original population boundaries are retained."
    },
    {
      "item_id": "N09",
      "question_type": "Evidence condition",
      "question": "Are walking effects long-term static-standing effects?",
      "needed": "Activity type, direct comparisons and equivalence boundaries",
      "role": "Required",
      "role_reason": "This condition connects Activity type, direct comparisons and equivalence boundaries with separate direct questions about long-term HbA1c and diabetes complications, the scope of acute materials, populations, static standing versus walking, comparators, denominators, cointerventions, registration, support and harms.",
      "application_exception": "Retain original grade ?, nonmeasurement of long-term outcomes and absent subclaim score, safety and axes. Positive first-day glucose/insulin iAUC, null next-day insulin and null acute Yates results are not direct long-term effects. Distinguish registered AUC/reported iAUC, the unverified meaning of ±, populations and condition-specific denominators, walking and the eight-week desk question. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, standing/exercise instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Activity type, direct comparisons and equivalence boundaries must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: The same comparator, activity types, actual exposure, direct long-term endpoints, between-group effects and CIs. No new exercise/standing instructions are written. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The original account distinguishes static standing from walking and states that a nonsignificant walking-versus-standing contrast does not establish equivalence. Walking signals are not transferred into long-term HbA1c/complication improvement from static standing.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "The same comparator, activity types, actual exposure, direct long-term endpoints, between-group effects and CIs. No new exercise/standing instructions are written.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "The same comparator, activity types, actual exposure, direct long-term endpoints, between-group effects and CIs. No new exercise/standing instructions are written."
    },
    {
      "item_id": "N10",
      "question_type": "Evidence condition",
      "question": "Does the eight-week desk material address the same long-term question?",
      "needed": "Original verdict 2245 desk question versus acute standing protocol",
      "role": "Required",
      "role_reason": "This condition connects Original verdict 2245 desk question versus acute standing protocol with separate direct questions about long-term HbA1c and diabetes complications, the scope of acute materials, populations, static standing versus walking, comparators, denominators, cointerventions, registration, support and harms.",
      "application_exception": "Retain original grade ?, nonmeasurement of long-term outcomes and absent subclaim score, safety and axes. Positive first-day glucose/insulin iAUC, null next-day insulin and null acute Yates results are not direct long-term effects. Distinguish registered AUC/reported iAUC, the unverified meaning of ±, populations and condition-specific denominators, walking and the eight-week desk question. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, standing/exercise instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Original verdict 2245 desk question versus acute standing protocol must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Direct original materials linking desk, standing, long-term HbA1c and complication questions. HbA1c or complication results are not invented from an eight-week reference. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The original account records protocol/core-endpoint differences between verdict 2245’s eight-week height-adjustable desk/broad cardiometabolic question and the present acute static-standing question. Verdict 2245 is not newly read or imported as new evidence.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Direct original materials linking desk, standing, long-term HbA1c and complication questions. HbA1c or complication results are not invented from an eight-week reference.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Direct original materials linking desk, standing, long-term HbA1c and complication questions. HbA1c or complication results are not invented from an eight-week reference."
    },
    {
      "item_id": "N11",
      "question_type": "Evidence condition",
      "question": "Are long-term analysis denominators and time at risk available?",
      "needed": "Acute sample sizes versus long-term HbA1c/event denominators",
      "role": "Required",
      "role_reason": "This condition connects Acute sample sizes versus long-term HbA1c/event denominators with separate direct questions about long-term HbA1c and diabetes complications, the scope of acute materials, populations, static standing versus walking, comparators, denominators, cointerventions, registration, support and harms.",
      "application_exception": "Retain original grade ?, nonmeasurement of long-term outcomes and absent subclaim score, safety and axes. Positive first-day glucose/insulin iAUC, null next-day insulin and null acute Yates results are not direct long-term effects. Distinguish registered AUC/reported iAUC, the unverified meaning of ±, populations and condition-specific denominators, walking and the eight-week desk question. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, standing/exercise instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Acute sample sizes versus long-term HbA1c/event denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Allocation, analysis, loss to follow-up, endpoint-specific denominators, time at risk and missing-data handling in direct long-term research. No new participant/event totals are created. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The 22 Henson participants and 60 analyzed by Yates are report-specific acute sample sizes. They are not valid long-term HbA1c analysis denominators or complication time-at-risk/event denominators. Repeated conditions are not counted as new participants.",
      "condition_status": "Unverified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Allocation, analysis, loss to follow-up, endpoint-specific denominators, time at risk and missing-data handling in direct long-term research. No new participant/event totals are created.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Allocation, analysis, loss to follow-up, endpoint-specific denominators, time at risk and missing-data handling in direct long-term research. No new participant/event totals are created."
    },
    {
      "item_id": "N12",
      "question_type": "Evidence condition",
      "question": "Are medication/diet changes separated from long-term effects?",
      "needed": "Acute laboratory day versus long-term cointerventions",
      "role": "Required",
      "role_reason": "This condition connects Acute laboratory day versus long-term cointerventions with separate direct questions about long-term HbA1c and diabetes complications, the scope of acute materials, populations, static standing versus walking, comparators, denominators, cointerventions, registration, support and harms.",
      "application_exception": "Retain original grade ?, nonmeasurement of long-term outcomes and absent subclaim score, safety and axes. Positive first-day glucose/insulin iAUC, null next-day insulin and null acute Yates results are not direct long-term effects. Distinguish registered AUC/reported iAUC, the unverified meaning of ±, populations and condition-specific denominators, walking and the eight-week desk question. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, standing/exercise instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Acute laboratory day versus long-term cointerventions must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Long-term cointerventions, actual exposure, comparator, treatment changes and direct estimates. No medication-change, replacement or treatment instructions are given. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The preserved account records an acute laboratory day and static-standing comparison. Actual medication, dietary and activity changes and sustained adherence during long-term follow-up are separately unverified.",
      "condition_status": "Unverified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Long-term cointerventions, actual exposure, comparator, treatment changes and direct estimates. No medication-change, replacement or treatment instructions are given.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Long-term cointerventions, actual exposure, comparator, treatment changes and direct estimates. No medication-change, replacement or treatment instructions are given."
    },
    {
      "item_id": "N13",
      "question_type": "Evidence condition",
      "question": "Does acute registration verify a prespecified long-term endpoint?",
      "needed": "Registered AUC/insulin, retrospective registration and long-term hierarchy",
      "role": "Required",
      "role_reason": "This condition connects Registered AUC/insulin, retrospective registration and long-term hierarchy with separate direct questions about long-term HbA1c and diabetes complications, the scope of acute materials, populations, static standing versus walking, comparators, denominators, cointerventions, registration, support and harms.",
      "application_exception": "Retain original grade ?, nonmeasurement of long-term outcomes and absent subclaim score, safety and axes. Positive first-day glucose/insulin iAUC, null next-day insulin and null acute Yates results are not direct long-term effects. Distinguish registered AUC/reported iAUC, the unverified meaning of ±, populations and condition-specific denominators, walking and the eight-week desk question. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, standing/exercise instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Registered AUC/insulin, retrospective registration and long-term hierarchy must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Registration dates, change history, protocols, SAPs, HbA1c/complication hierarchy and analysis plans for direct long-term endpoints. Registration/plans were not read in this work. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Preserve Henson’s registered primary AUC wording and retrospective-registration citation flag, and Yates’s primary insulin. NCT identifiers alone do not establish prospective status or measurement of long-term HbA1c or complications.",
      "condition_status": "Unverified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Registration dates, change history, protocols, SAPs, HbA1c/complication hierarchy and analysis plans for direct long-term endpoints. Registration/plans were not read in this work.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Registration dates, change history, protocols, SAPs, HbA1c/complication hierarchy and analysis plans for direct long-term endpoints. Registration/plans were not read in this work."
    },
    {
      "item_id": "N14",
      "question_type": "Evidence condition",
      "question": "What direct materials are needed to address the long-term gap?",
      "needed": "Separate direct evidence for HbA1c and complications",
      "role": "Required",
      "role_reason": "This condition connects Separate direct evidence for HbA1c and complications with separate direct questions about long-term HbA1c and diabetes complications, the scope of acute materials, populations, static standing versus walking, comparators, denominators, cointerventions, registration, support and harms.",
      "application_exception": "Retain original grade ?, nonmeasurement of long-term outcomes and absent subclaim score, safety and axes. Positive first-day glucose/insulin iAUC, null next-day insulin and null acute Yates results are not direct long-term effects. Distinguish registered AUC/reported iAUC, the unverified meaning of ±, populations and condition-specific denominators, walking and the eight-week desk question. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, standing/exercise instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Separate direct evidence for HbA1c and complications must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: The same static-standing intervention/comparator, sufficient duration, HbA1c values/CIs, complication definitions/events/denominators, actual exposure, cointerventions and original/content-review records. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Preserved acute static-standing materials contain both positive and null findings; direct long-term HbA1c/complication results are unverified. Material needs are recorded separately for the two questions, without executing new clinical judgment or research.",
      "condition_status": "Unverified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "The same static-standing intervention/comparator, sufficient duration, HbA1c values/CIs, complication definitions/events/denominators, actual exposure, cointerventions and original/content-review records.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "The same static-standing intervention/comparator, sufficient duration, HbA1c values/CIs, complication definitions/events/denominators, actual exposure, cointerventions and original/content-review records."
    },
    {
      "item_id": "N15",
      "question_type": "Evidence condition",
      "question": "Are shared reports counted as independent trials?",
      "needed": "Reports, cohorts, selected questions and repeated measurements",
      "role": "Required",
      "role_reason": "This condition connects Reports, cohorts, selected questions and repeated measurements with separate direct questions about long-term HbA1c and diabetes complications, the scope of acute materials, populations, static standing versus walking, comparators, denominators, cointerventions, registration, support and harms.",
      "application_exception": "Retain original grade ?, nonmeasurement of long-term outcomes and absent subclaim score, safety and axes. Positive first-day glucose/insulin iAUC, null next-day insulin and null acute Yates results are not direct long-term effects. Distinguish registered AUC/reported iAUC, the unverified meaning of ±, populations and condition-specific denominators, walking and the eight-week desk question. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, standing/exercise instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Reports, cohorts, selected questions and repeated measurements must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Report/cohort identities, incomplete-crossover conditions, shared researchers and analysis-population relationships. Unique counts and independence remain unverified. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Parent 2995 and both subclaim sheets share the Henson/Yates report context. Sheets, reports, crossover conditions and measurement days are not counted as new independent trials, and the 22 participants and 60 analyzed are not summed. Unique-trial and participant totals are unverified.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Report/cohort identities, incomplete-crossover conditions, shared researchers and analysis-population relationships. Unique counts and independence remain unverified.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Report/cohort identities, incomplete-crossover conditions, shared researchers and analysis-population relationships. Unique counts and independence remain unverified."
    },
    {
      "item_id": "N16",
      "question_type": "Evidence condition",
      "question": "Which materials were actually read?",
      "needed": "Stored summaries versus external originals and registration",
      "role": "Required",
      "role_reason": "This condition connects Stored summaries versus external originals and registration with separate direct questions about long-term HbA1c and diabetes complications, the scope of acute materials, populations, static standing versus walking, comparators, denominators, cointerventions, registration, support and harms.",
      "application_exception": "Retain original grade ?, nonmeasurement of long-term outcomes and absent subclaim score, safety and axes. Positive first-day glucose/insulin iAUC, null next-day insulin and null acute Yates results are not direct long-term effects. Distinguish registered AUC/reported iAUC, the unverified meaning of ±, populations and condition-specific denominators, walking and the eight-week desk question. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, standing/exercise instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Stored summaries versus external originals and registration must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Actual acquisition/reading records for originals, appendices, plans and registration. No new external retrieval or access attempt was made in this work. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The complete parent stored summary was read and transferred. External abstracts, full texts, registration, protocols and SAPs are unread; a URL does not establish successful access or a fulfilled condition.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Actual acquisition/reading records for originals, appendices, plans and registration. No new external retrieval or access attempt was made in this work.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Actual acquisition/reading records for originals, appendices, plans and registration. No new external retrieval or access attempt was made in this work."
    },
    {
      "item_id": "N17",
      "question_type": "Evidence condition",
      "question": "Where are bibliographic and registration identifiers recorded?",
      "needed": "DOI, PMID, PMCID and NCT in original citations",
      "role": "Required",
      "role_reason": "This condition connects DOI, PMID, PMCID and NCT in original citations with separate direct questions about long-term HbA1c and diabetes complications, the scope of acute materials, populations, static standing versus walking, comparators, denominators, cointerventions, registration, support and harms.",
      "application_exception": "Retain original grade ?, nonmeasurement of long-term outcomes and absent subclaim score, safety and axes. Positive first-day glucose/insulin iAUC, null next-day insulin and null acute Yates results are not direct long-term effects. Distinguish registered AUC/reported iAUC, the unverified meaning of ±, populations and condition-specific denominators, walking and the eight-week desk question. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, standing/exercise instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for DOI, PMID, PMCID and NCT in original citations must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original materials linking report and registration contents/timing. No new URLs are inferred from identifiers; original citation locations and wording are preserved. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Henson records PMID 26628415, DOI 10.2337/dc15-1240 and NCT02135172; Yates records PMID 30403772, PMCID PMC6909896, DOI 10.1093/gerona/gly252 and NCT02453204. The original evidence objects have no separate nct field.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Original materials linking report and registration contents/timing. No new URLs are inferred from identifiers; original citation locations and wording are preserved.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original materials linking report and registration contents/timing. No new URLs are inferred from identifiers; original citation locations and wording are preserved."
    },
    {
      "item_id": "N18",
      "question_type": "Evidence condition",
      "question": "Are historical bilingual checks distinguished from this work?",
      "needed": "Existing bilingual claims/notes and the scope of historical checks",
      "role": "Required",
      "role_reason": "This condition connects Existing bilingual claims/notes and the scope of historical checks with separate direct questions about long-term HbA1c and diabetes complications, the scope of acute materials, populations, static standing versus walking, comparators, denominators, cointerventions, registration, support and harms.",
      "application_exception": "Retain original grade ?, nonmeasurement of long-term outcomes and absent subclaim score, safety and axes. Positive first-day glucose/insulin iAUC, null next-day insulin and null acute Yates results are not direct long-term effects. Distinguish registered AUC/reported iAUC, the unverified meaning of ±, populations and condition-specific denominators, walking and the eight-week desk question. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, standing/exercise instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Existing bilingual claims/notes and the scope of historical checks must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original-text, translation, correction and claim-boundary review records. Historical checking language is not relabeled as completed current content review. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Original bilingual claims/notes and the parent’s historical account of checking two original trials, registries and overlap with 2245 are preserved. Citation statements that findings were checked are historical, not completion of new clinical review, registry verification or independent validation here.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Original-text, translation, correction and claim-boundary review records. Historical checking language is not relabeled as completed current content review.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original-text, translation, correction and claim-boundary review records. Historical checking language is not relabeled as completed current content review."
    },
    {
      "item_id": "N19",
      "question_type": "Evidence condition",
      "question": "Are subclaim values separated from parent grade/axes?",
      "needed": "Original subclaim grade ?, absent values and parent C54 context",
      "role": "Required",
      "role_reason": "This condition connects Original subclaim grade ?, absent values and parent C54 context with separate direct questions about long-term HbA1c and diabetes complications, the scope of acute materials, populations, static standing versus walking, comparators, denominators, cointerventions, registration, support and harms.",
      "application_exception": "Retain original grade ?, nonmeasurement of long-term outcomes and absent subclaim score, safety and axes. Positive first-day glucose/insulin iAUC, null next-day insulin and null acute Yates results are not direct long-term effects. Distinguish registered AUC/reported iAUC, the unverified meaning of ±, populations and condition-specific denominators, walking and the eight-week desk question. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, standing/exercise instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Original subclaim grade ?, absent values and parent C54 context must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original selected-subclaim/parent values and boundary checks. No new scores, axes, grades or efficacy reassessment are made. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Original subclaim grade ? and the acute-nonmeasurement note are retained; subclaim score, safety and axes remain unrecorded. Parent C54/Unknown and B/S/R0/I2/E+/B2/CX are parent context, not a score, safety rating or independence certification for the long-term claim.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Original selected-subclaim/parent values and boundary checks. No new scores, axes, grades or efficacy reassessment are made.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original selected-subclaim/parent values and boundary checks. No new scores, axes, grades or efficacy reassessment are made."
    },
    {
      "item_id": "N20",
      "question_type": "Evidence condition",
      "question": "Are evidence date, corrections and production date distinguished?",
      "needed": "Original evidence date and empty correction/deliberation records",
      "role": "Required",
      "role_reason": "This condition connects Original evidence date and empty correction/deliberation records with separate direct questions about long-term HbA1c and diabetes complications, the scope of acute materials, populations, static standing versus walking, comparators, denominators, cointerventions, registration, support and harms.",
      "application_exception": "Retain original grade ?, nonmeasurement of long-term outcomes and absent subclaim score, safety and axes. Positive first-day glucose/insulin iAUC, null next-day insulin and null acute Yates results are not direct long-term effects. Distinguish registered AUC/reported iAUC, the unverified meaning of ±, populations and condition-specific denominators, walking and the eight-week desk question. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, standing/exercise instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Original evidence date and empty correction/deliberation records must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Actual corrections, follow-up materials and complete pre-change history. Original dates and empty arrays are not filled arbitrarily. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Original evidence date 2026-09-07, an empty corrections array and an empty deliberation string are preserved. This is not the current production/content-review date; empty records do not certify that no external corrections exist.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Actual corrections, follow-up materials and complete pre-change history. Original dates and empty arrays are not filled arbitrarily.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Actual corrections, follow-up materials and complete pre-change history. Original dates and empty arrays are not filled arbitrarily."
    },
    {
      "item_id": "N21",
      "question_type": "Evidence condition",
      "question": "Are public funding and company involvement distinguished?",
      "needed": "Funding, product support, employee authors and analysis/reporting roles",
      "role": "Required",
      "role_reason": "This condition connects Funding, product support, employee authors and analysis/reporting roles with separate direct questions about long-term HbA1c and diabetes complications, the scope of acute materials, populations, static standing versus walking, comparators, denominators, cointerventions, registration, support and harms.",
      "application_exception": "Retain original grade ?, nonmeasurement of long-term outcomes and absent subclaim score, safety and axes. Positive first-day glucose/insulin iAUC, null next-day insulin and null acute Yates results are not direct long-term effects. Distinguish registered AUC/reported iAUC, the unverified meaning of ±, populations and condition-specific denominators, walking and the eight-week desk question. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, standing/exercise instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Funding, product support, employee authors and analysis/reporting roles must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original funding/COI, equipment/product support, author affiliations and analysis/publication roles. Parent I2 is not elevated into current independence certification. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Original funding is university/NIHR/NHS for Henson and UK public/university support for Yates. Public funding does not establish that product support, company employee authors or company analysis/reporting involvement are fully verified.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Original funding/COI, equipment/product support, author affiliations and analysis/publication roles. Parent I2 is not elevated into current independence certification.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original funding/COI, equipment/product support, author affiliations and analysis/publication roles. Parent I2 is not elevated into current independence certification."
    },
    {
      "item_id": "N22",
      "question_type": "Evidence condition",
      "question": "Are acute-crossover bias details verified?",
      "needed": "Allocation, order, measurement, missing data and selective reporting",
      "role": "Required",
      "role_reason": "This condition connects Allocation, order, measurement, missing data and selective reporting with separate direct questions about long-term HbA1c and diabetes complications, the scope of acute materials, populations, static standing versus walking, comparators, denominators, cointerventions, registration, support and harms.",
      "application_exception": "Retain original grade ?, nonmeasurement of long-term outcomes and absent subclaim score, safety and axes. Positive first-day glucose/insulin iAUC, null next-day insulin and null acute Yates results are not direct long-term effects. Distinguish registered AUC/reported iAUC, the unverified meaning of ±, populations and condition-specific denominators, walking and the eight-week desk question. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, standing/exercise instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Allocation, order, measurement, missing data and selective reporting must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original methods, registration, protocol, SAP, repeated-measures models, valid values/denominators and reporting changes. A design label does not establish official RoB/GRADE assessment or a passed content review. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Randomized acute incomplete-crossover/crossover design labels are preserved. Details of condition order, washout, period effects, allocation concealment, assessors, meal/measurement standardization, missing data and selective reporting are unverified.",
      "condition_status": "Unverified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Original methods, registration, protocol, SAP, repeated-measures models, valid values/denominators and reporting changes. A design label does not establish official RoB/GRADE assessment or a passed content review.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original methods, registration, protocol, SAP, repeated-measures models, valid values/denominators and reporting changes. A design label does not establish official RoB/GRADE assessment or a passed content review."
    },
    {
      "item_id": "N23",
      "question_type": "Evidence condition",
      "question": "Are actual standing exposure and concurrent activity known?",
      "needed": "Original protocol versus actual adherence/activity records",
      "role": "Required",
      "role_reason": "This condition connects Original protocol versus actual adherence/activity records with separate direct questions about long-term HbA1c and diabetes complications, the scope of acute materials, populations, static standing versus walking, comparators, denominators, cointerventions, registration, support and harms.",
      "application_exception": "Retain original grade ?, nonmeasurement of long-term outcomes and absent subclaim score, safety and axes. Positive first-day glucose/insulin iAUC, null next-day insulin and null acute Yates results are not direct long-term effects. Distinguish registered AUC/reported iAUC, the unverified meaning of ±, populations and condition-specific denominators, walking and the eight-week desk question. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, standing/exercise instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Original protocol versus actual adherence/activity records must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original exposure, activity, meal, measurement and adherence records. No new frequency/exposure totals or standing/exercise instructions are created. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The original 7.5 hours, five minutes every 30 minutes and total of 60 minutes of static standing are preserved only for research identification. Condition-specific actual adherence, movement, meals, concurrent activity and valid measurement denominators are unverified.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Original exposure, activity, meal, measurement and adherence records. No new frequency/exposure totals or standing/exercise instructions are created.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original exposure, activity, meal, measurement and adherence records. No new frequency/exposure totals or standing/exercise instructions are created."
    },
    {
      "item_id": "N24",
      "question_type": "Evidence condition",
      "question": "Are unknown safety and harm collection distinguished?",
      "needed": "Systematic harm collection, exposure, comparator and denominators",
      "role": "Supplementary",
      "role_reason": "This condition connects Systematic harm collection, exposure, comparator and denominators with separate direct questions about long-term HbA1c and diabetes complications, the scope of acute materials, populations, static standing versus walking, comparators, denominators, cointerventions, registration, support and harms.",
      "application_exception": "Retain original grade ?, nonmeasurement of long-term outcomes and absent subclaim score, safety and axes. Positive first-day glucose/insulin iAUC, null next-day insulin and null acute Yates results are not direct long-term effects. Distinguish registered AUC/reported iAUC, the unverified meaning of ±, populations and condition-specific denominators, walking and the eight-week desk question. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, standing/exercise instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Systematic harm collection, exposure, comparator and denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Adverse-event definitions, collection methods, group-specific exposure/denominators, withdrawals, severity and harm results. Unknown is not changed to safe or zero events. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Parent safety status is Unknown. The original safety explanation records that systematic adverse-event rates in the acute metabolic trials were unavailable. No new harm rates, event counts or between-condition CIs were verified here.",
      "condition_status": "Unverified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Adverse-event definitions, collection methods, group-specific exposure/denominators, withdrawals, severity and harm results. Unknown is not changed to safe or zero events.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Adverse-event definitions, collection methods, group-specific exposure/denominators, withdrawals, severity and harm results. Unknown is not changed to safe or zero events."
    },
    {
      "item_id": "N25",
      "question_type": "Evidence condition",
      "question": "What about selected participants able to stand and long-term harms?",
      "needed": "Orthostatic, vascular/musculoskeletal conditions and long-term boundaries",
      "role": "Supplementary",
      "role_reason": "This condition connects Orthostatic, vascular/musculoskeletal conditions and long-term boundaries with separate direct questions about long-term HbA1c and diabetes complications, the scope of acute materials, populations, static standing versus walking, comparators, denominators, cointerventions, registration, support and harms.",
      "application_exception": "Retain original grade ?, nonmeasurement of long-term outcomes and absent subclaim score, safety and axes. Positive first-day glucose/insulin iAUC, null next-day insulin and null acute Yates results are not direct long-term effects. Distinguish registered AUC/reported iAUC, the unverified meaning of ±, populations and condition-specific denominators, walking and the eight-week desk question. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, standing/exercise instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Orthostatic, vascular/musculoskeletal conditions and long-term boundaries must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Selection/exclusion criteria, comorbidities, harm surveillance, long-term exposure/denominators and actual follow-up. No new standing, exercise or treatment methods are written. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The original account says findings in selected participants able to stand cannot be generalized directly to people with orthostatic intolerance or vascular/musculoskeletal conditions. Rare harms and long-term risks are not established by the acute summary.",
      "condition_status": "Unverified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Selection/exclusion criteria, comorbidities, harm surveillance, long-term exposure/denominators and actual follow-up. No new standing, exercise or treatment methods are written.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Selection/exclusion criteria, comorbidities, harm surveillance, long-term exposure/denominators and actual follow-up. No new standing, exercise or treatment methods are written."
    },
    {
      "item_id": "N26",
      "question_type": "Evidence condition",
      "question": "Which materials would trigger an update?",
      "needed": "Separating source materials, applied conditions, observations and verdict changes",
      "role": "Required",
      "role_reason": "This condition connects Separating source materials, applied conditions, observations and verdict changes with separate direct questions about long-term HbA1c and diabetes complications, the scope of acute materials, populations, static standing versus walking, comparators, denominators, cointerventions, registration, support and harms.",
      "application_exception": "Retain original grade ?, nonmeasurement of long-term outcomes and absent subclaim score, safety and axes. Positive first-day glucose/insulin iAUC, null next-day insulin and null acute Yates results are not direct long-term effects. Distinguish registered AUC/reported iAUC, the unverified meaning of ±, populations and condition-specific denominators, walking and the eight-week desk question. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, standing/exercise instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Separating source materials, applied conditions, observations and verdict changes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Complete pre-change preservation, material/condition versions, separate application and review records. No new calculations, grades, independence certification or standing/exercise, medication-change or treatment guidance are created. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "This sheet transfers existing long-term HbA1c/complication content. Related observations can be updated when selected-subclaim/parent boundaries and original endpoint, timing, comparator, condition-specific denominator, registration, funding, shared-report and harm materials are verified.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Complete pre-change preservation, material/condition versions, separate application and review records. No new calculations, grades, independence certification or standing/exercise, medication-change or treatment guidance are created.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Complete pre-change preservation, material/condition versions, separate application and review records. No new calculations, grades, independence certification or standing/exercise, medication-change or treatment guidance are created."
    }
  ],
  "reports": [
    {
      "report_id": "R01",
      "title": "Henson J et al. Breaking Up Prolonged Sitting With Standing or Walking Attenuates the Postprandial Metabolic Response in Postmenopausal Women: A Randomized Acute Study. Diabetes Care. 2016;39(1):130-138. PMID: 26628415. DOI: 10.2337/dc15-1240. NCT02135172.",
      "url": "https://pubmed.ncbi.nlm.nih.gov/26628415/",
      "report_type": "Randomized acute incomplete-crossover trial",
      "existence": "Report linked in the original parent stored summary evidence/citation lists. External public availability, access and current acquisition of the original are unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "study_family": "Shared preserved Henson/Yates report context; cohort relationships, unique counts and independence unverified",
      "independent_replication": "Parent 2995 and both subclaim sheets share these reports. The same research team, crossover conditions and measurement days are not counted as new independent trials; unique-trial and participant totals are unverified.",
      "observed_result": "glucose iAUC −34%, P=.022; insulin iAUC −20%, P=.045",
      "result_level": "Acute background report for the long-term question. Preserve only the incomplete crossover in 22 overweight or obese postmenopausal women with dysglycemia, experience of two of three conditions, first-day positive findings and null next-day insulin. It does not supply direct long-term HbA1c/complication results, denominators or CIs; next-day glucose, the meaning of ± and condition-specific analysis denominators are also unverified.",
      "source_evidence_date": "2026-09-07",
      "materials": [
        {
          "material_type": "Stored existing review summary",
          "public_status": "Preserved copy of the complete parent-verdict stored summary",
          "access_status": "Stored summary",
          "acquired": true,
          "actually_read": "Summary read",
          "as_of": "2026-09-07",
          "qualification": "Preserve the original PubMed URL, PMID 26628415, DOI 10.2337/dc15-1240, citation NCT02135172 and retrospective-registration flag. A separate evidence nct field and PMCID are unrecorded. Registered-primary AUC is original wording; registration contents, dates, prospective status and plan adherence are unverified in this work."
        },
        {
          "material_type": "External abstract",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": null,
          "qualification": "Preserve the original PubMed URL, PMID 26628415, DOI 10.2337/dc15-1240, citation NCT02135172 and retrospective-registration flag. A separate evidence nct field and PMCID are unrecorded. Registered-primary AUC is original wording; registration contents, dates, prospective status and plan adherence are unverified in this work."
        },
        {
          "material_type": "External full text",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": null,
          "qualification": "Preserve the original PubMed URL, PMID 26628415, DOI 10.2337/dc15-1240, citation NCT02135172 and retrospective-registration flag. A separate evidence nct field and PMCID are unrecorded. Registered-primary AUC is original wording; registration contents, dates, prospective status and plan adherence are unverified in this work."
        },
        {
          "material_type": "Registration material",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": null,
          "qualification": "Preserve the original PubMed URL, PMID 26628415, DOI 10.2337/dc15-1240, citation NCT02135172 and retrospective-registration flag. A separate evidence nct field and PMCID are unrecorded. Registered-primary AUC is original wording; registration contents, dates, prospective status and plan adherence are unverified in this work."
        },
        {
          "material_type": "Protocol/SAP",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
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          "qualification": "Preserve the original PubMed URL, PMID 26628415, DOI 10.2337/dc15-1240, citation NCT02135172 and retrospective-registration flag. A separate evidence nct field and PMCID are unrecorded. Registered-primary AUC is original wording; registration contents, dates, prospective status and plan adherence are unverified in this work."
        }
      ],
      "links": [
        {
          "label": "PubMed",
          "url": "https://pubmed.ncbi.nlm.nih.gov/26628415/"
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    {
      "report_id": "R02",
      "title": "Yates T et al. Metabolic Effects of Breaking Prolonged Sitting With Standing or Light Walking in Older South Asians and White Europeans: A Randomized Acute Study. J Gerontol A Biol Sci Med Sci. 2020;75(1):139-146. PMID: 30403772. PMCID: PMC6909896. DOI: 10.1093/gerona/gly252. NCT02453204.",
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      "existence": "Report linked in the original parent stored summary evidence/citation lists. External public availability, access and current acquisition of the original are unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "study_family": "Shared preserved Henson/Yates report context; cohort relationships, unique counts and independence unverified",
      "independent_replication": "Parent 2995 and both subclaim sheets share these reports. The same research team, crossover conditions and measurement days are not counted as new independent trials; unique-trial and participant totals are unverified.",
      "observed_result": "Standing versus uninterrupted sitting was null for primary insulin and glucose",
      "result_level": "For the long-term question, this is conflicting acute background from 60 analyzed in a different older population. Preserve the South Asians/White Europeans bibliography and null standing-versus-sitting primary insulin/glucose findings. It is not a direct null trial of long-term HbA1c or complications; precise effects, CIs, P values and condition-specific denominators are unverified.",
      "source_evidence_date": "2026-09-07",
      "materials": [
        {
          "material_type": "Stored existing review summary",
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          "acquired": true,
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        },
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        },
        {
          "material_type": "External full text",
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          "as_of": null,
          "qualification": "Preserve the original PubMed URL, PMID 30403772, PMCID PMC6909896, DOI 10.1093/gerona/gly252 and citation NCT02453204. A separate evidence nct field is unrecorded; Henson’s retrospective-registration flag is not transferred into an established registration date for this report. No new registry/full-text URLs are inferred; contents, timing, reading and prospective status remain unverified."
        },
        {
          "material_type": "Registration material",
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          "as_of": null,
          "qualification": "Preserve the original PubMed URL, PMID 30403772, PMCID PMC6909896, DOI 10.1093/gerona/gly252 and citation NCT02453204. A separate evidence nct field is unrecorded; Henson’s retrospective-registration flag is not transferred into an established registration date for this report. No new registry/full-text URLs are inferred; contents, timing, reading and prospective status remain unverified."
        },
        {
          "material_type": "Protocol/SAP",
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          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": null,
          "qualification": "Preserve the original PubMed URL, PMID 30403772, PMCID PMC6909896, DOI 10.1093/gerona/gly252 and citation NCT02453204. A separate evidence nct field is unrecorded; Henson’s retrospective-registration flag is not transferred into an established registration date for this report. No new registry/full-text URLs are inferred; contents, timing, reading and prospective status remain unverified."
        }
      ],
      "links": [
        {
          "label": "PubMed",
          "url": "https://pubmed.ncbi.nlm.nih.gov/30403772/"
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      ]
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  ],
  "method_sources": [
    {
      "id": "M03",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03",
      "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13",
      "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M04",
      "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04",
      "section": "§4.5, §4.6.1–4.6.3, MECIR C42",
      "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M08",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08",
      "section": "§8.1–8.2.3, Table 8.2.a",
      "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M15",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15",
      "section": "§15.2.4, §15.3.1–15.3.3",
      "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M19",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19",
      "section": "§19.1.2, §19.2.1–19.2.4",
      "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    }
  ],
  "status_dictionary": {
    "Partly verified": "Some information is present in the stored source, with detailed original materials still unverified; this does not mean review passed or clinical efficacy certified",
    "Unverified": "Detailed materials for the selected condition could not be established within the stored scope; this does not mean zero effect, zero studies or safety",
    "Review incomplete": "Awaiting user review",
    "Met": "Use only within the relevant condition's scope after user review; no automatic display in this preparation",
    "Not reported": "Distinguish only within materials actually read; do not turn unread external materials into unreported findings",
    "Inaccessible": "Not applied during this preparation because actual access was not tested",
    "Not applicable": "Use with a reason for non-applicability based on an explicit question boundary",
    "Conflicting data": "Judge after actual material comparison; review was not performed during this preparation",
    "Insufficient evidence for the conditions": "Do not use as a clinical grade encompassing currently unread materials"
  },
  "study_overlap": {
    "state": "Unverified",
    "unique_trial_count": null,
    "unique_participant_count": null,
    "reason": "Parent 2995 and the same-day/long-term subclaim sheets share the preserved Henson/Yates report context. The same research team, two citations, crossover conditions and measurement days are not counted as new independent trials or participants. The 22 Henson participants and 60 analyzed by Yates are not summed; unique-trial/participant totals and cohort overlap are unverified."
  },
  "history": [
    {
      "date": "2026-10-16",
      "kind": "Separation of public-facing pages and materials",
      "view_version": "1.0",
      "change": "The reader view and materials were prepared from the existing 26 items. No new clinical search, verification-status changes or scoring were performed."
    }
  ],
  "language": "en",
  "translation_date": "2026-10-16"
}