{
  "schema_version": "chamgap-public-criteria-1.0",
  "title": "Static standing × long-term HbA1c or diabetes complications",
  "language": "en",
  "translation_date": "2026-10-16",
  "criteria_version": "1.0",
  "criteria_date": "2026-10-06",
  "condition_origin": "Chamgap's own application conditions",
  "method_sources": [
    {
      "id": "M03",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03",
      "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13",
      "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M04",
      "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04",
      "section": "§4.5, §4.6.1–4.6.3, MECIR C42",
      "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M08",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08",
      "section": "§8.1–8.2.3, Table 8.2.a",
      "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M15",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15",
      "section": "§15.2.4, §15.3.1–15.3.3",
      "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M19",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19",
      "section": "§19.1.2, §19.2.1–19.2.4",
      "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    }
  ],
  "status_dictionary": {
    "Partly verified": "Some information is present in the stored source, with detailed original materials still unverified; this does not mean review passed or clinical efficacy certified",
    "Unverified": "Detailed materials for the selected condition could not be established within the stored scope; this does not mean zero effect, zero studies or safety",
    "Review incomplete": "Awaiting user review",
    "Met": "Use only within the relevant condition's scope after user review; no automatic display in this preparation",
    "Not reported": "Distinguish only within materials actually read; do not turn unread external materials into unreported findings",
    "Inaccessible": "Not applied during this preparation because actual access was not tested",
    "Not applicable": "Use with a reason for non-applicability based on an explicit question boundary",
    "Conflicting data": "Judge after actual material comparison; review was not performed during this preparation",
    "Insufficient evidence for the conditions": "Do not use as a clinical grade encompassing currently unread materials"
  },
  "requirements": [
    {
      "item_id": "N01",
      "question_type": "Evidence condition",
      "question": "Which long-term claim is being checked?",
      "needed": "Separate direct questions about long-term HbA1c and diabetes complications",
      "role": "Required",
      "role_reason": "This condition connects Separate direct questions about long-term HbA1c and diabetes complications with separate direct questions about long-term HbA1c and diabetes complications, the scope of acute materials, populations, static standing versus walking, comparators, denominators, cointerventions, registration, support and harms.",
      "application_exception": "Retain original grade ?, nonmeasurement of long-term outcomes and absent subclaim score, safety and axes. Positive first-day glucose/insulin iAUC, null next-day insulin and null acute Yates results are not direct long-term effects. Distinguish registered AUC/reported iAUC, the unverified meaning of ±, populations and condition-specific denominators, walking and the eight-week desk question. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, standing/exercise instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Separate direct questions about long-term HbA1c and diabetes complications must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Materials identifying long-term HbA1c and complications as separate direct questions, with claim-boundary checks. The ? is not changed into a zero score or no effect. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N02",
      "question_type": "Evidence condition",
      "question": "Was long-term HbA1c measured directly?",
      "needed": "Long-term HbA1c results for static standing",
      "role": "Required",
      "role_reason": "This condition connects Long-term HbA1c results for static standing with separate direct questions about long-term HbA1c and diabetes complications, the scope of acute materials, populations, static standing versus walking, comparators, denominators, cointerventions, registration, support and harms.",
      "application_exception": "Retain original grade ?, nonmeasurement of long-term outcomes and absent subclaim score, safety and axes. Positive first-day glucose/insulin iAUC, null next-day insulin and null acute Yates results are not direct long-term effects. Distinguish registered AUC/reported iAUC, the unverified meaning of ±, populations and condition-specific denominators, walking and the eight-week desk question. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, standing/exercise instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Long-term HbA1c results for static standing must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Long-term HbA1c values/changes, timing, comparator, denominators, CIs and medication/diet cointerventions. Nonmeasurement is not changed into zero effect. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N03",
      "question_type": "Evidence condition",
      "question": "Were diabetes complications measured directly?",
      "needed": "Complication types, event definitions and direct comparisons",
      "role": "Required",
      "role_reason": "This condition connects Complication types, event definitions and direct comparisons with separate direct questions about long-term HbA1c and diabetes complications, the scope of acute materials, populations, static standing versus walking, comparators, denominators, cointerventions, registration, support and harms.",
      "application_exception": "Retain original grade ?, nonmeasurement of long-term outcomes and absent subclaim score, safety and axes. Positive first-day glucose/insulin iAUC, null next-day insulin and null acute Yates results are not direct long-term effects. Distinguish registered AUC/reported iAUC, the unverified meaning of ±, populations and condition-specific denominators, walking and the eight-week desk question. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, standing/exercise instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Complication types, event definitions and direct comparisons must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Complication-specific definitions, event assessment/collection, long-term follow-up, group-specific events/denominators, effects and CIs. Unverified findings are not changed into zero events or zero preventive effects. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N04",
      "question_type": "Evidence condition",
      "question": "Is first-day glucose iAUC a long-term treatment effect?",
      "needed": "Acute glucose surrogate versus direct long-term evidence",
      "role": "Required",
      "role_reason": "This condition connects Acute glucose surrogate versus direct long-term evidence with separate direct questions about long-term HbA1c and diabetes complications, the scope of acute materials, populations, static standing versus walking, comparators, denominators, cointerventions, registration, support and harms.",
      "application_exception": "Retain original grade ?, nonmeasurement of long-term outcomes and absent subclaim score, safety and axes. Positive first-day glucose/insulin iAUC, null next-day insulin and null acute Yates results are not direct long-term effects. Distinguish registered AUC/reported iAUC, the unverified meaning of ±, populations and condition-specific denominators, walking and the eight-week desk question. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, standing/exercise instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Acute glucose surrogate versus direct long-term evidence must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Direct materials linking acute responses and long-term endpoints, long-term intervention comparisons, the meaning of ± and direct CIs. No new effect/risk calculations or hypothetical numerical examples are created. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N05",
      "question_type": "Evidence condition",
      "question": "Is insulin change a direct complication result?",
      "needed": "Distinguishing insulin responses, glucose and long-term clinical outcomes",
      "role": "Required",
      "role_reason": "This condition connects Distinguishing insulin responses, glucose and long-term clinical outcomes with separate direct questions about long-term HbA1c and diabetes complications, the scope of acute materials, populations, static standing versus walking, comparators, denominators, cointerventions, registration, support and harms.",
      "application_exception": "Retain original grade ?, nonmeasurement of long-term outcomes and absent subclaim score, safety and axes. Positive first-day glucose/insulin iAUC, null next-day insulin and null acute Yates results are not direct long-term effects. Distinguish registered AUC/reported iAUC, the unverified meaning of ±, populations and condition-specific denominators, walking and the eight-week desk question. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, standing/exercise instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Distinguishing insulin responses, glucose and long-term clinical outcomes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original insulin-endpoint definition, meaning of ±, direct CIs and long-term clinical materials. The same effect/P is not copied across different endpoints. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N06",
      "question_type": "Evidence condition",
      "question": "Does a null next-day result establish a null long-term effect?",
      "needed": "Separating first-day, next-day and long-term findings",
      "role": "Required",
      "role_reason": "This condition connects Separating first-day, next-day and long-term findings with separate direct questions about long-term HbA1c and diabetes complications, the scope of acute materials, populations, static standing versus walking, comparators, denominators, cointerventions, registration, support and harms.",
      "application_exception": "Retain original grade ?, nonmeasurement of long-term outcomes and absent subclaim score, safety and axes. Positive first-day glucose/insulin iAUC, null next-day insulin and null acute Yates results are not direct long-term effects. Distinguish registered AUC/reported iAUC, the unverified meaning of ±, populations and condition-specific denominators, walking and the eight-week desk question. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, standing/exercise instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Separating first-day, next-day and long-term findings must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original day-specific findings, timing, denominators, direct effects/CIs and long-term follow-up for each endpoint. Short-term null findings are not transferred into zero long-term effects. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N07",
      "question_type": "Evidence condition",
      "question": "Is the Yates standing-only null result a long-term outcome?",
      "needed": "Acute primary insulin/glucose versus long-term endpoints",
      "role": "Required",
      "role_reason": "This condition connects Acute primary insulin/glucose versus long-term endpoints with separate direct questions about long-term HbA1c and diabetes complications, the scope of acute materials, populations, static standing versus walking, comparators, denominators, cointerventions, registration, support and harms.",
      "application_exception": "Retain original grade ?, nonmeasurement of long-term outcomes and absent subclaim score, safety and axes. Positive first-day glucose/insulin iAUC, null next-day insulin and null acute Yates results are not direct long-term effects. Distinguish registered AUC/reported iAUC, the unverified meaning of ±, populations and condition-specific denominators, walking and the eight-week desk question. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, standing/exercise instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Acute primary insulin/glucose versus long-term endpoints must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Actual studies of direct long-term endpoints and original acute analysis tables/CIs. Null findings do not establish equivalence, zero effect or absence of all long-term research. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N08",
      "question_type": "Evidence condition",
      "question": "Can the selected population represent everyone with established diabetes?",
      "needed": "Postmenopausal women with dysglycemia versus long-term target populations",
      "role": "Required",
      "role_reason": "This condition connects Postmenopausal women with dysglycemia versus long-term target populations with separate direct questions about long-term HbA1c and diabetes complications, the scope of acute materials, populations, static standing versus walking, comparators, denominators, cointerventions, registration, support and harms.",
      "application_exception": "Retain original grade ?, nonmeasurement of long-term outcomes and absent subclaim score, safety and axes. Positive first-day glucose/insulin iAUC, null next-day insulin and null acute Yates results are not direct long-term effects. Distinguish registered AUC/reported iAUC, the unverified meaning of ±, populations and condition-specific denominators, walking and the eight-week desk question. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, standing/exercise instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Postmenopausal women with dysglycemia versus long-term target populations must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Diagnostic criteria, medications, baseline HbA1c, disease/complications, eligibility and baseline risk for the long-term question. Original population boundaries are retained. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N09",
      "question_type": "Evidence condition",
      "question": "Are walking effects long-term static-standing effects?",
      "needed": "Activity type, direct comparisons and equivalence boundaries",
      "role": "Required",
      "role_reason": "This condition connects Activity type, direct comparisons and equivalence boundaries with separate direct questions about long-term HbA1c and diabetes complications, the scope of acute materials, populations, static standing versus walking, comparators, denominators, cointerventions, registration, support and harms.",
      "application_exception": "Retain original grade ?, nonmeasurement of long-term outcomes and absent subclaim score, safety and axes. Positive first-day glucose/insulin iAUC, null next-day insulin and null acute Yates results are not direct long-term effects. Distinguish registered AUC/reported iAUC, the unverified meaning of ±, populations and condition-specific denominators, walking and the eight-week desk question. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, standing/exercise instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Activity type, direct comparisons and equivalence boundaries must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: The same comparator, activity types, actual exposure, direct long-term endpoints, between-group effects and CIs. No new exercise/standing instructions are written. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N10",
      "question_type": "Evidence condition",
      "question": "Does the eight-week desk material address the same long-term question?",
      "needed": "Original verdict 2245 desk question versus acute standing protocol",
      "role": "Required",
      "role_reason": "This condition connects Original verdict 2245 desk question versus acute standing protocol with separate direct questions about long-term HbA1c and diabetes complications, the scope of acute materials, populations, static standing versus walking, comparators, denominators, cointerventions, registration, support and harms.",
      "application_exception": "Retain original grade ?, nonmeasurement of long-term outcomes and absent subclaim score, safety and axes. Positive first-day glucose/insulin iAUC, null next-day insulin and null acute Yates results are not direct long-term effects. Distinguish registered AUC/reported iAUC, the unverified meaning of ±, populations and condition-specific denominators, walking and the eight-week desk question. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, standing/exercise instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Original verdict 2245 desk question versus acute standing protocol must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Direct original materials linking desk, standing, long-term HbA1c and complication questions. HbA1c or complication results are not invented from an eight-week reference. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N11",
      "question_type": "Evidence condition",
      "question": "Are long-term analysis denominators and time at risk available?",
      "needed": "Acute sample sizes versus long-term HbA1c/event denominators",
      "role": "Required",
      "role_reason": "This condition connects Acute sample sizes versus long-term HbA1c/event denominators with separate direct questions about long-term HbA1c and diabetes complications, the scope of acute materials, populations, static standing versus walking, comparators, denominators, cointerventions, registration, support and harms.",
      "application_exception": "Retain original grade ?, nonmeasurement of long-term outcomes and absent subclaim score, safety and axes. Positive first-day glucose/insulin iAUC, null next-day insulin and null acute Yates results are not direct long-term effects. Distinguish registered AUC/reported iAUC, the unverified meaning of ±, populations and condition-specific denominators, walking and the eight-week desk question. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, standing/exercise instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Acute sample sizes versus long-term HbA1c/event denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Allocation, analysis, loss to follow-up, endpoint-specific denominators, time at risk and missing-data handling in direct long-term research. No new participant/event totals are created. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N12",
      "question_type": "Evidence condition",
      "question": "Are medication/diet changes separated from long-term effects?",
      "needed": "Acute laboratory day versus long-term cointerventions",
      "role": "Required",
      "role_reason": "This condition connects Acute laboratory day versus long-term cointerventions with separate direct questions about long-term HbA1c and diabetes complications, the scope of acute materials, populations, static standing versus walking, comparators, denominators, cointerventions, registration, support and harms.",
      "application_exception": "Retain original grade ?, nonmeasurement of long-term outcomes and absent subclaim score, safety and axes. Positive first-day glucose/insulin iAUC, null next-day insulin and null acute Yates results are not direct long-term effects. Distinguish registered AUC/reported iAUC, the unverified meaning of ±, populations and condition-specific denominators, walking and the eight-week desk question. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, standing/exercise instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Acute laboratory day versus long-term cointerventions must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Long-term cointerventions, actual exposure, comparator, treatment changes and direct estimates. No medication-change, replacement or treatment instructions are given. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N13",
      "question_type": "Evidence condition",
      "question": "Does acute registration verify a prespecified long-term endpoint?",
      "needed": "Registered AUC/insulin, retrospective registration and long-term hierarchy",
      "role": "Required",
      "role_reason": "This condition connects Registered AUC/insulin, retrospective registration and long-term hierarchy with separate direct questions about long-term HbA1c and diabetes complications, the scope of acute materials, populations, static standing versus walking, comparators, denominators, cointerventions, registration, support and harms.",
      "application_exception": "Retain original grade ?, nonmeasurement of long-term outcomes and absent subclaim score, safety and axes. Positive first-day glucose/insulin iAUC, null next-day insulin and null acute Yates results are not direct long-term effects. Distinguish registered AUC/reported iAUC, the unverified meaning of ±, populations and condition-specific denominators, walking and the eight-week desk question. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, standing/exercise instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Registered AUC/insulin, retrospective registration and long-term hierarchy must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Registration dates, change history, protocols, SAPs, HbA1c/complication hierarchy and analysis plans for direct long-term endpoints. Registration/plans were not read in this work. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N14",
      "question_type": "Evidence condition",
      "question": "What direct materials are needed to address the long-term gap?",
      "needed": "Separate direct evidence for HbA1c and complications",
      "role": "Required",
      "role_reason": "This condition connects Separate direct evidence for HbA1c and complications with separate direct questions about long-term HbA1c and diabetes complications, the scope of acute materials, populations, static standing versus walking, comparators, denominators, cointerventions, registration, support and harms.",
      "application_exception": "Retain original grade ?, nonmeasurement of long-term outcomes and absent subclaim score, safety and axes. Positive first-day glucose/insulin iAUC, null next-day insulin and null acute Yates results are not direct long-term effects. Distinguish registered AUC/reported iAUC, the unverified meaning of ±, populations and condition-specific denominators, walking and the eight-week desk question. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, standing/exercise instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Separate direct evidence for HbA1c and complications must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: The same static-standing intervention/comparator, sufficient duration, HbA1c values/CIs, complication definitions/events/denominators, actual exposure, cointerventions and original/content-review records. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N15",
      "question_type": "Evidence condition",
      "question": "Are shared reports counted as independent trials?",
      "needed": "Reports, cohorts, selected questions and repeated measurements",
      "role": "Required",
      "role_reason": "This condition connects Reports, cohorts, selected questions and repeated measurements with separate direct questions about long-term HbA1c and diabetes complications, the scope of acute materials, populations, static standing versus walking, comparators, denominators, cointerventions, registration, support and harms.",
      "application_exception": "Retain original grade ?, nonmeasurement of long-term outcomes and absent subclaim score, safety and axes. Positive first-day glucose/insulin iAUC, null next-day insulin and null acute Yates results are not direct long-term effects. Distinguish registered AUC/reported iAUC, the unverified meaning of ±, populations and condition-specific denominators, walking and the eight-week desk question. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, standing/exercise instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Reports, cohorts, selected questions and repeated measurements must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Report/cohort identities, incomplete-crossover conditions, shared researchers and analysis-population relationships. Unique counts and independence remain unverified. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N16",
      "question_type": "Evidence condition",
      "question": "Which materials were actually read?",
      "needed": "Stored summaries versus external originals and registration",
      "role": "Required",
      "role_reason": "This condition connects Stored summaries versus external originals and registration with separate direct questions about long-term HbA1c and diabetes complications, the scope of acute materials, populations, static standing versus walking, comparators, denominators, cointerventions, registration, support and harms.",
      "application_exception": "Retain original grade ?, nonmeasurement of long-term outcomes and absent subclaim score, safety and axes. Positive first-day glucose/insulin iAUC, null next-day insulin and null acute Yates results are not direct long-term effects. Distinguish registered AUC/reported iAUC, the unverified meaning of ±, populations and condition-specific denominators, walking and the eight-week desk question. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, standing/exercise instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Stored summaries versus external originals and registration must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Actual acquisition/reading records for originals, appendices, plans and registration. No new external retrieval or access attempt was made in this work. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N17",
      "question_type": "Evidence condition",
      "question": "Where are bibliographic and registration identifiers recorded?",
      "needed": "DOI, PMID, PMCID and NCT in original citations",
      "role": "Required",
      "role_reason": "This condition connects DOI, PMID, PMCID and NCT in original citations with separate direct questions about long-term HbA1c and diabetes complications, the scope of acute materials, populations, static standing versus walking, comparators, denominators, cointerventions, registration, support and harms.",
      "application_exception": "Retain original grade ?, nonmeasurement of long-term outcomes and absent subclaim score, safety and axes. Positive first-day glucose/insulin iAUC, null next-day insulin and null acute Yates results are not direct long-term effects. Distinguish registered AUC/reported iAUC, the unverified meaning of ±, populations and condition-specific denominators, walking and the eight-week desk question. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, standing/exercise instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for DOI, PMID, PMCID and NCT in original citations must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original materials linking report and registration contents/timing. No new URLs are inferred from identifiers; original citation locations and wording are preserved. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N18",
      "question_type": "Evidence condition",
      "question": "Are historical bilingual checks distinguished from this work?",
      "needed": "Existing bilingual claims/notes and the scope of historical checks",
      "role": "Required",
      "role_reason": "This condition connects Existing bilingual claims/notes and the scope of historical checks with separate direct questions about long-term HbA1c and diabetes complications, the scope of acute materials, populations, static standing versus walking, comparators, denominators, cointerventions, registration, support and harms.",
      "application_exception": "Retain original grade ?, nonmeasurement of long-term outcomes and absent subclaim score, safety and axes. Positive first-day glucose/insulin iAUC, null next-day insulin and null acute Yates results are not direct long-term effects. Distinguish registered AUC/reported iAUC, the unverified meaning of ±, populations and condition-specific denominators, walking and the eight-week desk question. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, standing/exercise instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Existing bilingual claims/notes and the scope of historical checks must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original-text, translation, correction and claim-boundary review records. Historical checking language is not relabeled as completed current content review. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N19",
      "question_type": "Evidence condition",
      "question": "Are subclaim values separated from parent grade/axes?",
      "needed": "Original subclaim grade ?, absent values and parent C54 context",
      "role": "Required",
      "role_reason": "This condition connects Original subclaim grade ?, absent values and parent C54 context with separate direct questions about long-term HbA1c and diabetes complications, the scope of acute materials, populations, static standing versus walking, comparators, denominators, cointerventions, registration, support and harms.",
      "application_exception": "Retain original grade ?, nonmeasurement of long-term outcomes and absent subclaim score, safety and axes. Positive first-day glucose/insulin iAUC, null next-day insulin and null acute Yates results are not direct long-term effects. Distinguish registered AUC/reported iAUC, the unverified meaning of ±, populations and condition-specific denominators, walking and the eight-week desk question. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, standing/exercise instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Original subclaim grade ?, absent values and parent C54 context must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original selected-subclaim/parent values and boundary checks. No new scores, axes, grades or efficacy reassessment are made. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N20",
      "question_type": "Evidence condition",
      "question": "Are evidence date, corrections and production date distinguished?",
      "needed": "Original evidence date and empty correction/deliberation records",
      "role": "Required",
      "role_reason": "This condition connects Original evidence date and empty correction/deliberation records with separate direct questions about long-term HbA1c and diabetes complications, the scope of acute materials, populations, static standing versus walking, comparators, denominators, cointerventions, registration, support and harms.",
      "application_exception": "Retain original grade ?, nonmeasurement of long-term outcomes and absent subclaim score, safety and axes. Positive first-day glucose/insulin iAUC, null next-day insulin and null acute Yates results are not direct long-term effects. Distinguish registered AUC/reported iAUC, the unverified meaning of ±, populations and condition-specific denominators, walking and the eight-week desk question. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, standing/exercise instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Original evidence date and empty correction/deliberation records must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Actual corrections, follow-up materials and complete pre-change history. Original dates and empty arrays are not filled arbitrarily. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N21",
      "question_type": "Evidence condition",
      "question": "Are public funding and company involvement distinguished?",
      "needed": "Funding, product support, employee authors and analysis/reporting roles",
      "role": "Required",
      "role_reason": "This condition connects Funding, product support, employee authors and analysis/reporting roles with separate direct questions about long-term HbA1c and diabetes complications, the scope of acute materials, populations, static standing versus walking, comparators, denominators, cointerventions, registration, support and harms.",
      "application_exception": "Retain original grade ?, nonmeasurement of long-term outcomes and absent subclaim score, safety and axes. Positive first-day glucose/insulin iAUC, null next-day insulin and null acute Yates results are not direct long-term effects. Distinguish registered AUC/reported iAUC, the unverified meaning of ±, populations and condition-specific denominators, walking and the eight-week desk question. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, standing/exercise instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Funding, product support, employee authors and analysis/reporting roles must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original funding/COI, equipment/product support, author affiliations and analysis/publication roles. Parent I2 is not elevated into current independence certification. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N22",
      "question_type": "Evidence condition",
      "question": "Are acute-crossover bias details verified?",
      "needed": "Allocation, order, measurement, missing data and selective reporting",
      "role": "Required",
      "role_reason": "This condition connects Allocation, order, measurement, missing data and selective reporting with separate direct questions about long-term HbA1c and diabetes complications, the scope of acute materials, populations, static standing versus walking, comparators, denominators, cointerventions, registration, support and harms.",
      "application_exception": "Retain original grade ?, nonmeasurement of long-term outcomes and absent subclaim score, safety and axes. Positive first-day glucose/insulin iAUC, null next-day insulin and null acute Yates results are not direct long-term effects. Distinguish registered AUC/reported iAUC, the unverified meaning of ±, populations and condition-specific denominators, walking and the eight-week desk question. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, standing/exercise instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Allocation, order, measurement, missing data and selective reporting must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original methods, registration, protocol, SAP, repeated-measures models, valid values/denominators and reporting changes. A design label does not establish official RoB/GRADE assessment or a passed content review. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N23",
      "question_type": "Evidence condition",
      "question": "Are actual standing exposure and concurrent activity known?",
      "needed": "Original protocol versus actual adherence/activity records",
      "role": "Required",
      "role_reason": "This condition connects Original protocol versus actual adherence/activity records with separate direct questions about long-term HbA1c and diabetes complications, the scope of acute materials, populations, static standing versus walking, comparators, denominators, cointerventions, registration, support and harms.",
      "application_exception": "Retain original grade ?, nonmeasurement of long-term outcomes and absent subclaim score, safety and axes. Positive first-day glucose/insulin iAUC, null next-day insulin and null acute Yates results are not direct long-term effects. Distinguish registered AUC/reported iAUC, the unverified meaning of ±, populations and condition-specific denominators, walking and the eight-week desk question. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, standing/exercise instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Original protocol versus actual adherence/activity records must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original exposure, activity, meal, measurement and adherence records. No new frequency/exposure totals or standing/exercise instructions are created. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N24",
      "question_type": "Evidence condition",
      "question": "Are unknown safety and harm collection distinguished?",
      "needed": "Systematic harm collection, exposure, comparator and denominators",
      "role": "Supplementary",
      "role_reason": "This condition connects Systematic harm collection, exposure, comparator and denominators with separate direct questions about long-term HbA1c and diabetes complications, the scope of acute materials, populations, static standing versus walking, comparators, denominators, cointerventions, registration, support and harms.",
      "application_exception": "Retain original grade ?, nonmeasurement of long-term outcomes and absent subclaim score, safety and axes. Positive first-day glucose/insulin iAUC, null next-day insulin and null acute Yates results are not direct long-term effects. Distinguish registered AUC/reported iAUC, the unverified meaning of ±, populations and condition-specific denominators, walking and the eight-week desk question. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, standing/exercise instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Systematic harm collection, exposure, comparator and denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Adverse-event definitions, collection methods, group-specific exposure/denominators, withdrawals, severity and harm results. Unknown is not changed to safe or zero events. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N25",
      "question_type": "Evidence condition",
      "question": "What about selected participants able to stand and long-term harms?",
      "needed": "Orthostatic, vascular/musculoskeletal conditions and long-term boundaries",
      "role": "Supplementary",
      "role_reason": "This condition connects Orthostatic, vascular/musculoskeletal conditions and long-term boundaries with separate direct questions about long-term HbA1c and diabetes complications, the scope of acute materials, populations, static standing versus walking, comparators, denominators, cointerventions, registration, support and harms.",
      "application_exception": "Retain original grade ?, nonmeasurement of long-term outcomes and absent subclaim score, safety and axes. Positive first-day glucose/insulin iAUC, null next-day insulin and null acute Yates results are not direct long-term effects. Distinguish registered AUC/reported iAUC, the unverified meaning of ±, populations and condition-specific denominators, walking and the eight-week desk question. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, standing/exercise instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Orthostatic, vascular/musculoskeletal conditions and long-term boundaries must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Selection/exclusion criteria, comorbidities, harm surveillance, long-term exposure/denominators and actual follow-up. No new standing, exercise or treatment methods are written. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N26",
      "question_type": "Evidence condition",
      "question": "Which materials would trigger an update?",
      "needed": "Separating source materials, applied conditions, observations and verdict changes",
      "role": "Required",
      "role_reason": "This condition connects Separating source materials, applied conditions, observations and verdict changes with separate direct questions about long-term HbA1c and diabetes complications, the scope of acute materials, populations, static standing versus walking, comparators, denominators, cointerventions, registration, support and harms.",
      "application_exception": "Retain original grade ?, nonmeasurement of long-term outcomes and absent subclaim score, safety and axes. Positive first-day glucose/insulin iAUC, null next-day insulin and null acute Yates results are not direct long-term effects. Distinguish registered AUC/reported iAUC, the unverified meaning of ±, populations and condition-specific denominators, walking and the eight-week desk question. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, standing/exercise instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Separating source materials, applied conditions, observations and verdict changes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Complete pre-change preservation, material/condition versions, separate application and review records. No new calculations, grades, independence certification or standing/exercise, medication-change or treatment guidance are created. This records needed materials; no new research was executed."
    }
  ]
}