{
  "schema_version": "chamgap-public-evidence-check-1.0",
  "public_id": "v2995-s0",
  "verdict_number": "2995",
  "title": "Static standing × same-day iAUC in selected women",
  "view_version": "1.0",
  "view_created_date": "2026-10-16",
  "criteria_version": "1.0",
  "criteria_date": "2026-10-06",
  "review_date": null,
  "legacy_evidence_date": "2026-09-07",
  "review_scope": {
    "materials_read": "Existing review summaries and stored records of methodological application",
    "clinical_papers_directly_read": false,
    "new_clinical_search": false,
    "limitation": "Existing stored summary and preserved methodology application records. External papers, abstracts, registration, protocols, SAPs, original result tables and support disclosures are unread, and review of existing content remains incomplete.",
    "date_meaning": "This is the date the stored materials were checked, not the date of a new search of the clinical literature."
  },
  "claim_context": {
    "population": "The positive Henson sample comprised 22 overweight or obese postmenopausal women with dysglycemia. The related Yates analysis of 60 participants concerns a different older population, described bibliographically as South Asians and White Europeans. Exact eligibility, ages, baseline values and condition-specific denominators are unverified; findings are not extended to everyone with established diabetes.",
    "intervention": "The original research exposure was motionless static standing for five minutes every 30 minutes during a 7.5-hour day. It is distinguished from walking and the eight-week height-adjustable-desk question. The research record is not turned into personal standing/exercise instructions or a prescription.",
    "dose": "Preserve only the original recorded total of 60 minutes per day. Actual condition-specific adherence, movement, meals and concurrent activity are unverified. No frequency, total exposure, dose conversion or new schedule is calculated.",
    "comparator": "The direct comparator was uninterrupted sitting. Walking is a different activity condition and its effects are not transferred to standing. A nonsignificant walking-versus-standing contrast does not prove equivalence. Details of condition-specific direct contrasts, order, washout and concurrent management are unverified.",
    "endpoint": "First-day glucose iAUC was 5.3±0.8 with sitting versus 3.5±0.8 mmol/L·h with standing (P=.022), with an original −34% record; insulin iAUC was 548.2±71.8 versus 437.2±73.5 mU/L·h (P=.045), with an original −20% record. Registered endpoint AUC and reported iAUC wording remain distinct. The meaning of ±, direct CIs, models and condition-specific denominators are unverified; no new differences or CIs are calculated.",
    "duration": "Distinguish first-day findings during a single 7.5-hour laboratory day from null next-day insulin. The exact next-day glucose result is unverified. Long-term HbA1c and diabetes complications in the other subclaim were not measured by the original acute trials; the same-day signal is not extended to long-term management, prevention or treatment.",
    "excluded_extensions": [
      "Extending findings in selected postmenopausal women with dysglycemia to all overweight adults or everyone with established diabetes",
      "Transferring first-day glucose/insulin iAUC to next-day or long-term HbA1c/complications outcomes or single-time-point concentrations",
      "Treating walking effects as standing effects or certifying nonsignificant/null findings as equivalence or zero effect",
      "Reading ± values as CIs or calculating new absolute differences, effects, confidence intervals, unique-trial/participant totals or exposure totals",
      "Inheriting parent C54/Unknown, I2, registered-primary wording or historical checks as absent subclaim values, current review, prospective status or independence certification",
      "Treating the eight-week desk question as identical exposure or generating standing/exercise instructions, medication changes or diabetes treatment guidance"
    ]
  },
  "requirements": [
    {
      "item_id": "N01",
      "question_type": "Evidence condition",
      "question": "Which same-day iAUC claim is being checked?",
      "needed": "Same-day postprandial iAUC in selected overweight women",
      "role": "Required",
      "role_reason": "This condition connects Same-day postprandial iAUC in selected overweight women with same-day iAUC in selected women, static standing versus walking, populations, direct comparators, condition-specific denominators, next-day/long-term boundaries, registration, support and harms.",
      "application_exception": "Preserve original numbers, units and research exposure only. Distinguish first-day glucose/insulin iAUC from next-day null insulin, registered AUC from reported iAUC, 22 participants in Henson’s incomplete crossover from 60 older adults analyzed by Yates, and static standing from walking and long-term desk questions. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, exercise/standing instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Same-day postprandial iAUC in selected overweight women must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original materials identifying the selected population, static standing, comparator, endpoint/time and claim boundaries. The parent score is not used to fill the absent subclaim score. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The existing subclaim is lower same-day postprandial iAUC in selected overweight women, originally graded C, with a glucose −34%/insulin −20% note. Subclaim score and safety status are unrecorded and remain distinct from the broader parent C54 question.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Original materials identifying the selected population, static standing, comparator, endpoint/time and claim boundaries. The parent score is not used to fill the absent subclaim score.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original materials identifying the selected population, static standing, comparator, endpoint/time and claim boundaries. The parent score is not used to fill the absent subclaim score."
    },
    {
      "item_id": "N02",
      "question_type": "Evidence condition",
      "question": "Who comprised the positive sample?",
      "needed": "Overweight or obese postmenopausal women with dysglycemia",
      "role": "Required",
      "role_reason": "This condition connects Overweight or obese postmenopausal women with dysglycemia with same-day iAUC in selected women, static standing versus walking, populations, direct comparators, condition-specific denominators, next-day/long-term boundaries, registration, support and harms.",
      "application_exception": "Preserve original numbers, units and research exposure only. Distinguish first-day glucose/insulin iAUC from next-day null insulin, registered AUC from reported iAUC, 22 participants in Henson’s incomplete crossover from 60 older adults analyzed by Yates, and static standing from walking and long-term desk questions. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, exercise/standing instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Overweight or obese postmenopausal women with dysglycemia must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original eligibility, menopause/glycemia criteria, baseline glucose, medications, comorbidities, ability-to-stand criteria and subgroup denominators. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The positive Henson sample comprised 22 overweight or obese postmenopausal women with dysglycemia. This does not establish the same effect in everyone with established diabetes or in all overweight adults.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Original eligibility, menopause/glycemia criteria, baseline glucose, medications, comorbidities, ability-to-stand criteria and subgroup denominators.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original eligibility, menopause/glycemia criteria, baseline glucose, medications, comorbidities, ability-to-stand criteria and subgroup denominators."
    },
    {
      "item_id": "N03",
      "question_type": "Evidence condition",
      "question": "What was the first-day glucose iAUC result?",
      "needed": "Henson first-day glucose iAUC and direct comparison",
      "role": "Required",
      "role_reason": "This condition connects Henson first-day glucose iAUC and direct comparison with same-day iAUC in selected women, static standing versus walking, populations, direct comparators, condition-specific denominators, next-day/long-term boundaries, registration, support and harms.",
      "application_exception": "Preserve original numbers, units and research exposure only. Distinguish first-day glucose/insulin iAUC from next-day null insulin, registered AUC from reported iAUC, 22 participants in Henson’s incomplete crossover from 60 older adults analyzed by Yates, and static standing from walking and long-term desk questions. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, exercise/standing instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Henson first-day glucose iAUC and direct comparison must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: iAUC baseline/integration interval, model, condition-specific analysis denominators, direct between-condition estimate/CI and the meaning of ±. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The original values were 5.3±0.8 with uninterrupted sitting versus 3.5±0.8 mmol/L·h with standing, P=.022, with a −34% record. These are not converted into a single-time-point glucose concentration or used to calculate a new absolute between-condition difference or CI.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "iAUC baseline/integration interval, model, condition-specific analysis denominators, direct between-condition estimate/CI and the meaning of ±.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "iAUC baseline/integration interval, model, condition-specific analysis denominators, direct between-condition estimate/CI and the meaning of ±."
    },
    {
      "item_id": "N04",
      "question_type": "Evidence condition",
      "question": "Is first-day insulin iAUC a separate endpoint?",
      "needed": "Henson first-day insulin iAUC",
      "role": "Required",
      "role_reason": "This condition connects Henson first-day insulin iAUC with same-day iAUC in selected women, static standing versus walking, populations, direct comparators, condition-specific denominators, next-day/long-term boundaries, registration, support and harms.",
      "application_exception": "Preserve original numbers, units and research exposure only. Distinguish first-day glucose/insulin iAUC from next-day null insulin, registered AUC from reported iAUC, 22 participants in Henson’s incomplete crossover from 60 older adults analyzed by Yates, and static standing from walking and long-term desk questions. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, exercise/standing instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Henson first-day insulin iAUC must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Insulin iAUC definition, original curves, model, denominators, direct CI, meaning of ±, endpoint hierarchy and relationship to glucose. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The original values were 548.2±71.8 versus 437.2±73.5 mU/L·h, P=.045, with a −20% record. These differ from glucose iAUC values/P and are not transferred into insulin concentrations or complication effects.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Insulin iAUC definition, original curves, model, denominators, direct CI, meaning of ±, endpoint hierarchy and relationship to glucose.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Insulin iAUC definition, original curves, model, denominators, direct CI, meaning of ±, endpoint hierarchy and relationship to glucose."
    },
    {
      "item_id": "N05",
      "question_type": "Evidence condition",
      "question": "Were next-day findings the same?",
      "needed": "First-day positive findings versus null next-day insulin",
      "role": "Required",
      "role_reason": "This condition connects First-day positive findings versus null next-day insulin with same-day iAUC in selected women, static standing versus walking, populations, direct comparators, condition-specific denominators, next-day/long-term boundaries, registration, support and harms.",
      "application_exception": "Preserve original numbers, units and research exposure only. Distinguish first-day glucose/insulin iAUC from next-day null insulin, registered AUC from reported iAUC, 22 participants in Henson’s incomplete crossover from 60 older adults analyzed by Yates, and static standing from walking and long-term desk questions. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, exercise/standing instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for First-day positive findings versus null next-day insulin must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Next-day conditions, denominators, effects, CIs, P values and original tables for each endpoint. Null findings do not establish zero difference or absence of long-term effects. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The original account records a null next-day insulin difference. First-day positive glucose/insulin findings are not copied into the next day; the exact next-day glucose result, values and P are unverified.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Next-day conditions, denominators, effects, CIs, P values and original tables for each endpoint. Null findings do not establish zero difference or absence of long-term effects.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Next-day conditions, denominators, effects, CIs, P values and original tables for each endpoint. Null findings do not establish zero difference or absence of long-term effects."
    },
    {
      "item_id": "N06",
      "question_type": "Evidence condition",
      "question": "What did the related older-adult trial find for standing alone?",
      "needed": "Primary insulin and glucose in the 60 analyzed by Yates",
      "role": "Required",
      "role_reason": "This condition connects Primary insulin and glucose in the 60 analyzed by Yates with same-day iAUC in selected women, static standing versus walking, populations, direct comparators, condition-specific denominators, next-day/long-term boundaries, registration, support and harms.",
      "application_exception": "Preserve original numbers, units and research exposure only. Distinguish first-day glucose/insulin iAUC from next-day null insulin, registered AUC from reported iAUC, 22 participants in Henson’s incomplete crossover from 60 older adults analyzed by Yates, and static standing from walking and long-term desk questions. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, exercise/standing instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Primary insulin and glucose in the 60 analyzed by Yates must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original result tables, primary-endpoint hierarchy, population/condition denominators, effects, CIs, P values and missing data. Null findings do not prove zero effect or equivalence. This records needed materials; no new research was executed.",
      "current_reports": [
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The Yates acute crossover trial records 60 analyzed and null standing-versus-uninterrupted-sitting findings for primary insulin and glucose. Exact effects, CIs, P values and condition-specific analysis denominators are unverified.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Original result tables, primary-endpoint hierarchy, population/condition denominators, effects, CIs, P values and missing data. Null findings do not prove zero effect or equivalence.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original result tables, primary-endpoint hierarchy, population/condition denominators, effects, CIs, P values and missing data. Null findings do not prove zero effect or equivalence."
    },
    {
      "item_id": "N07",
      "question_type": "Evidence condition",
      "question": "How are standing and walking separated?",
      "needed": "Activity type, direct comparisons and equivalence boundaries",
      "role": "Required",
      "role_reason": "This condition connects Activity type, direct comparisons and equivalence boundaries with same-day iAUC in selected women, static standing versus walking, populations, direct comparators, condition-specific denominators, next-day/long-term boundaries, registration, support and harms.",
      "application_exception": "Preserve original numbers, units and research exposure only. Distinguish first-day glucose/insulin iAUC from next-day null insulin, registered AUC from reported iAUC, 22 participants in Henson’s incomplete crossover from 60 older adults analyzed by Yates, and static standing from walking and long-term desk questions. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, exercise/standing instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Activity type, direct comparisons and equivalence boundaries must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Activity-specific direct comparisons, effects/CIs, prespecified equivalence criteria, denominators and actual activity records. No new activity instructions are written. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The original account describes walking as more consistently favorable. A nonsignificant walking-versus-standing contrast does not prove equivalence, and walking effects are not transferred to standing.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Activity-specific direct comparisons, effects/CIs, prespecified equivalence criteria, denominators and actual activity records. No new activity instructions are written.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Activity-specific direct comparisons, effects/CIs, prespecified equivalence criteria, denominators and actual activity records. No new activity instructions are written."
    },
    {
      "item_id": "N08",
      "question_type": "Evidence condition",
      "question": "What was the original static-standing exposure?",
      "needed": "Identification of motionless standing, laboratory day and comparator",
      "role": "Required",
      "role_reason": "This condition connects Identification of motionless standing, laboratory day and comparator with same-day iAUC in selected women, static standing versus walking, populations, direct comparators, condition-specific denominators, next-day/long-term boundaries, registration, support and harms.",
      "application_exception": "Preserve original numbers, units and research exposure only. Distinguish first-day glucose/insulin iAUC from next-day null insulin, registered AUC from reported iAUC, 22 participants in Henson’s incomplete crossover from 60 older adults analyzed by Yates, and static standing from walking and long-term desk questions. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, exercise/standing instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Identification of motionless standing, laboratory day and comparator must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Actual protocol, movement/standing verification, meals, concurrent activity, adherence and exposure data. Height-adjustable desks and walking are not substituted. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The original record describes five minutes of standing every 30 minutes during 7.5 hours and an already recorded total of 60 minutes of motionless standing per day. Only the preserved total is retained; frequency/exposure is not newly calculated and no implementation instructions are created.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Actual protocol, movement/standing verification, meals, concurrent activity, adherence and exposure data. Height-adjustable desks and walking are not substituted.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Actual protocol, movement/standing verification, meals, concurrent activity, adherence and exposure data. Height-adjustable desks and walking are not substituted."
    },
    {
      "item_id": "N09",
      "question_type": "Evidence condition",
      "question": "Did all 22 participants complete every condition?",
      "needed": "Incomplete crossover and condition-specific analysis denominators",
      "role": "Required",
      "role_reason": "This condition connects Incomplete crossover and condition-specific analysis denominators with same-day iAUC in selected women, static standing versus walking, populations, direct comparators, condition-specific denominators, next-day/long-term boundaries, registration, support and harms.",
      "application_exception": "Preserve original numbers, units and research exposure only. Distinguish first-day glucose/insulin iAUC from next-day null insulin, registered AUC from reported iAUC, 22 participants in Henson’s incomplete crossover from 60 older adults analyzed by Yates, and static standing from walking and long-term desk questions. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, exercise/standing instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Incomplete crossover and condition-specific analysis denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Condition combinations/order, washout, period effects, valid condition-specific denominators and allocation/analysis flow. Repeated crossover observations are not counted as additional participants. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Henson was a randomized acute incomplete-crossover trial in which 22 participants experienced two of uninterrupted sitting, standing and walking. They are not presented as a denominator completing all three conditions.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Condition combinations/order, washout, period effects, valid condition-specific denominators and allocation/analysis flow. Repeated crossover observations are not counted as additional participants.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Condition combinations/order, washout, period effects, valid condition-specific denominators and allocation/analysis flow. Repeated crossover observations are not counted as additional participants."
    },
    {
      "item_id": "N10",
      "question_type": "Evidence condition",
      "question": "Do registered AUC and reported iAUC have matching definitions?",
      "needed": "AUC/iAUC wording and endpoint definitions",
      "role": "Required",
      "role_reason": "This condition connects AUC/iAUC wording and endpoint definitions with same-day iAUC in selected women, static standing versus walking, populations, direct comparators, condition-specific denominators, next-day/long-term boundaries, registration, support and harms.",
      "application_exception": "Preserve original numbers, units and research exposure only. Distinguish first-day glucose/insulin iAUC from next-day null insulin, registered AUC from reported iAUC, 22 participants in Henson’s incomplete crossover from 60 older adults analyzed by Yates, and static standing from walking and long-term desk questions. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, exercise/standing instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for AUC/iAUC wording and endpoint definitions must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original registered endpoint, AUC/iAUC definitions, baseline/negative-area handling, SAP and analysis tables. No arbitrary terminology correction or new discrepancy verdict is created. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The original evidence endpoint is registered primary postprandial glucose AUC, while results and explanations use glucose iAUC. Both wordings are preserved; matching definitions are not established through a new external registry/paper comparison.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Original registered endpoint, AUC/iAUC definitions, baseline/negative-area handling, SAP and analysis tables. No arbitrary terminology correction or new discrepancy verdict is created.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original registered endpoint, AUC/iAUC definitions, baseline/negative-area handling, SAP and analysis tables. No arbitrary terminology correction or new discrepancy verdict is created."
    },
    {
      "item_id": "N11",
      "question_type": "Evidence condition",
      "question": "Were the positive and null populations identical?",
      "needed": "Selected women versus a different older population",
      "role": "Required",
      "role_reason": "This condition connects Selected women versus a different older population with same-day iAUC in selected women, static standing versus walking, populations, direct comparators, condition-specific denominators, next-day/long-term boundaries, registration, support and harms.",
      "application_exception": "Preserve original numbers, units and research exposure only. Distinguish first-day glucose/insulin iAUC from next-day null insulin, registered AUC from reported iAUC, 22 participants in Henson’s incomplete crossover from 60 older adults analyzed by Yates, and static standing from walking and long-term desk questions. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, exercise/standing instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Selected women versus a different older population must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Report-specific eligibility, sex, age, glycemia, ethnic background, baseline values, denominators and prespecified effect-modification analyses. Conflicting directions and parent R0 are retained. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The positive population was overweight postmenopausal women with dysglycemia; the related analysis of 60 concerns a different older population. The Yates bibliography records older South Asians and White Europeans. Findings in another population from the same research team are not copied into the selected population.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Report-specific eligibility, sex, age, glycemia, ethnic background, baseline values, denominators and prespecified effect-modification analyses. Conflicting directions and parent R0 are retained.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Report-specific eligibility, sex, age, glycemia, ethnic background, baseline values, denominators and prespecified effect-modification analyses. Conflicting directions and parent R0 are retained."
    },
    {
      "item_id": "N12",
      "question_type": "Evidence condition",
      "question": "Are registered-primary and retrospective-registration statements distinguished?",
      "needed": "Registry identifiers, timing, prospective status and endpoint hierarchy",
      "role": "Required",
      "role_reason": "This condition connects Registry identifiers, timing, prospective status and endpoint hierarchy with same-day iAUC in selected women, static standing versus walking, populations, direct comparators, condition-specific denominators, next-day/long-term boundaries, registration, support and harms.",
      "application_exception": "Preserve original numbers, units and research exposure only. Distinguish first-day glucose/insulin iAUC from next-day null insulin, registered AUC from reported iAUC, 22 participants in Henson’s incomplete crossover from 60 older adults analyzed by Yates, and static standing from walking and long-term desk questions. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, exercise/standing instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Registry identifiers, timing, prospective status and endpoint hierarchy must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Initial/changed registration dates, protocols, SAPs, actual start/result-report dates and endpoint hierarchy. Registered-primary wording alone does not certify preregistration or plan adherence. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Henson is described as a registered-primary positive signal, but the citation note flags retrospective registration. NCT02135172/NCT02453204 are original citation identifiers; registration dates, changes and prospective status are unread in this work.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Initial/changed registration dates, protocols, SAPs, actual start/result-report dates and endpoint hierarchy. Registered-primary wording alone does not certify preregistration or plan adherence.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Initial/changed registration dates, protocols, SAPs, actual start/result-report dates and endpoint hierarchy. Registered-primary wording alone does not certify preregistration or plan adherence."
    },
    {
      "item_id": "N13",
      "question_type": "Evidence condition",
      "question": "Are direct CIs and the meaning of ± available?",
      "needed": "Effect intervals and variation definitions for each endpoint/time/contrast",
      "role": "Required",
      "role_reason": "This condition connects Effect intervals and variation definitions for each endpoint/time/contrast with same-day iAUC in selected women, static standing versus walking, populations, direct comparators, condition-specific denominators, next-day/long-term boundaries, registration, support and harms.",
      "application_exception": "Preserve original numbers, units and research exposure only. Distinguish first-day glucose/insulin iAUC from next-day null insulin, registered AUC from reported iAUC, 22 participants in Henson’s incomplete crossover from 60 older adults analyzed by Yates, and static standing from walking and long-term desk questions. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, exercise/standing instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Effect intervals and variation definitions for each endpoint/time/contrast must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original model, effect estimator, variation definitions, direct CIs and condition-specific measurements/denominators. No new absolute differences, CIs or relative effects are calculated. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "First-day condition-specific ± values, P values and relative reductions are recorded for both iAUC endpoints, but direct between-condition 95% CIs, the meaning of ± and exact Yates/next-day effect intervals are unverified. The ± values are not made into CIs.",
      "condition_status": "Unverified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Original model, effect estimator, variation definitions, direct CIs and condition-specific measurements/denominators. No new absolute differences, CIs or relative effects are calculated.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original model, effect estimator, variation definitions, direct CIs and condition-specific measurements/denominators. No new absolute differences, CIs or relative effects are calculated."
    },
    {
      "item_id": "N14",
      "question_type": "Evidence condition",
      "question": "What is the clinical meaning of same-day iAUC?",
      "needed": "Acute metabolic measures versus long-term clinical importance",
      "role": "Required",
      "role_reason": "This condition connects Acute metabolic measures versus long-term clinical importance with same-day iAUC in selected women, static standing versus walking, populations, direct comparators, condition-specific denominators, next-day/long-term boundaries, registration, support and harms.",
      "application_exception": "Preserve original numbers, units and research exposure only. Distinguish first-day glucose/insulin iAUC from next-day null insulin, registered AUC from reported iAUC, 22 participants in Henson’s incomplete crossover from 60 older adults analyzed by Yates, and static standing from walking and long-term desk questions. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, exercise/standing instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Acute metabolic measures versus long-term clinical importance must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Clinical-importance criteria for the selected population and direct long-term endpoints. No hypothetical glucose-change or risk-reduction examples are created. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The original parent describes a conditional acute surrogate signal. The original 34%/20% or first-day P values are not converted into long-term HbA1c, diabetes complications or treatment effects.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Clinical-importance criteria for the selected population and direct long-term endpoints. No hypothetical glucose-change or risk-reduction examples are created.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Clinical-importance criteria for the selected population and direct long-term endpoints. No hypothetical glucose-change or risk-reduction examples are created."
    },
    {
      "item_id": "N15",
      "question_type": "Evidence condition",
      "question": "Were long-term HbA1c or complications measured?",
      "needed": "Boundaries on extending the same-day question",
      "role": "Required",
      "role_reason": "This condition connects Boundaries on extending the same-day question with same-day iAUC in selected women, static standing versus walking, populations, direct comparators, condition-specific denominators, next-day/long-term boundaries, registration, support and harms.",
      "application_exception": "Preserve original numbers, units and research exposure only. Distinguish first-day glucose/insulin iAUC from next-day null insulin, registered AUC from reported iAUC, 22 participants in Henson’s incomplete crossover from 60 older adults analyzed by Yates, and static standing from walking and long-term desk questions. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, exercise/standing instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Boundaries on extending the same-day question must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Direct long-term HbA1c/complication definitions, duration, group-specific denominators, effects and CIs. Nonmeasurement does not certify no effect or the absence of all long-term research. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The other existing subclaim, improved long-term HbA1c or diabetes complications, is graded ?, with an original note that the acute trials did not measure these outcomes. Same-day/next-day materials are not extended into long-term improvement.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Direct long-term HbA1c/complication definitions, duration, group-specific denominators, effects and CIs. Nonmeasurement does not certify no effect or the absence of all long-term research.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Direct long-term HbA1c/complication definitions, duration, group-specific denominators, effects and CIs. Nonmeasurement does not certify no effect or the absence of all long-term research."
    },
    {
      "item_id": "N16",
      "question_type": "Evidence condition",
      "question": "Is this the same as the eight-week adjustable-desk question?",
      "needed": "Original verdict 2245 reference and protocol/endpoint differences",
      "role": "Required",
      "role_reason": "This condition connects Original verdict 2245 reference and protocol/endpoint differences with same-day iAUC in selected women, static standing versus walking, populations, direct comparators, condition-specific denominators, next-day/long-term boundaries, registration, support and harms.",
      "application_exception": "Preserve original numbers, units and research exposure only. Distinguish first-day glucose/insulin iAUC from next-day null insulin, registered AUC from reported iAUC, 22 participants in Henson’s incomplete crossover from 60 older adults analyzed by Yates, and static standing from walking and long-term desk questions. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, exercise/standing instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Original verdict 2245 reference and protocol/endpoint differences must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Materials comparing those questions with the original protocols/endpoints. Desk installation or long-term management is not treated as a same-day static-standing effect. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The original account distinguishes the protocol and core endpoint from verdict 2245’s eight-week height-adjustable desk and broad cardiometabolic question. That verdict is not newly read or assigned a newly constructed link here.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Materials comparing those questions with the original protocols/endpoints. Desk installation or long-term management is not treated as a same-day static-standing effect.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Materials comparing those questions with the original protocols/endpoints. Desk installation or long-term management is not treated as a same-day static-standing effect."
    },
    {
      "item_id": "N17",
      "question_type": "Evidence condition",
      "question": "Are shared reports counted as independent trials?",
      "needed": "Reports, cohorts, selected questions and repeated measurements",
      "role": "Required",
      "role_reason": "This condition connects Reports, cohorts, selected questions and repeated measurements with same-day iAUC in selected women, static standing versus walking, populations, direct comparators, condition-specific denominators, next-day/long-term boundaries, registration, support and harms.",
      "application_exception": "Preserve original numbers, units and research exposure only. Distinguish first-day glucose/insulin iAUC from next-day null insulin, registered AUC from reported iAUC, 22 participants in Henson’s incomplete crossover from 60 older adults analyzed by Yates, and static standing from walking and long-term desk questions. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, exercise/standing instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Reports, cohorts, selected questions and repeated measurements must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Report/cohort identities, incomplete-crossover conditions, shared researchers and analysis-population relationships. Unique counts and independence remain unverified. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Parent 2995 and both subclaim sheets share the Henson/Yates report context. Sheets, reports, crossover conditions and measurement days are not counted as new independent trials, and the 22 participants and 60 analyzed are not summed. Unique-trial and participant totals are unverified.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Report/cohort identities, incomplete-crossover conditions, shared researchers and analysis-population relationships. Unique counts and independence remain unverified.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Report/cohort identities, incomplete-crossover conditions, shared researchers and analysis-population relationships. Unique counts and independence remain unverified."
    },
    {
      "item_id": "N18",
      "question_type": "Evidence condition",
      "question": "Which materials were actually read?",
      "needed": "Stored summaries versus external originals and registration",
      "role": "Required",
      "role_reason": "This condition connects Stored summaries versus external originals and registration with same-day iAUC in selected women, static standing versus walking, populations, direct comparators, condition-specific denominators, next-day/long-term boundaries, registration, support and harms.",
      "application_exception": "Preserve original numbers, units and research exposure only. Distinguish first-day glucose/insulin iAUC from next-day null insulin, registered AUC from reported iAUC, 22 participants in Henson’s incomplete crossover from 60 older adults analyzed by Yates, and static standing from walking and long-term desk questions. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, exercise/standing instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Stored summaries versus external originals and registration must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Actual acquisition/reading records for originals, appendices, plans and registration. No new external retrieval or access attempt was made in this work. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The complete parent stored summary was read and transferred. External abstracts, full texts, registration, protocols and SAPs are unread; a URL does not establish successful access or a fulfilled condition.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Actual acquisition/reading records for originals, appendices, plans and registration. No new external retrieval or access attempt was made in this work.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Actual acquisition/reading records for originals, appendices, plans and registration. No new external retrieval or access attempt was made in this work."
    },
    {
      "item_id": "N19",
      "question_type": "Evidence condition",
      "question": "Where are bibliographic and registration identifiers recorded?",
      "needed": "DOI, PMID, PMCID and NCT in original citations",
      "role": "Required",
      "role_reason": "This condition connects DOI, PMID, PMCID and NCT in original citations with same-day iAUC in selected women, static standing versus walking, populations, direct comparators, condition-specific denominators, next-day/long-term boundaries, registration, support and harms.",
      "application_exception": "Preserve original numbers, units and research exposure only. Distinguish first-day glucose/insulin iAUC from next-day null insulin, registered AUC from reported iAUC, 22 participants in Henson’s incomplete crossover from 60 older adults analyzed by Yates, and static standing from walking and long-term desk questions. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, exercise/standing instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for DOI, PMID, PMCID and NCT in original citations must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original materials linking report and registration contents/timing. No new URLs are inferred from identifiers; original citation locations and wording are preserved. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Henson records PMID 26628415, DOI 10.2337/dc15-1240 and NCT02135172; Yates records PMID 30403772, PMCID PMC6909896, DOI 10.1093/gerona/gly252 and NCT02453204. The original evidence objects have no separate nct field.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Original materials linking report and registration contents/timing. No new URLs are inferred from identifiers; original citation locations and wording are preserved.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original materials linking report and registration contents/timing. No new URLs are inferred from identifiers; original citation locations and wording are preserved."
    },
    {
      "item_id": "N20",
      "question_type": "Evidence condition",
      "question": "Are historical bilingual checks distinguished from this work?",
      "needed": "Existing bilingual claims/notes and the scope of historical checks",
      "role": "Required",
      "role_reason": "This condition connects Existing bilingual claims/notes and the scope of historical checks with same-day iAUC in selected women, static standing versus walking, populations, direct comparators, condition-specific denominators, next-day/long-term boundaries, registration, support and harms.",
      "application_exception": "Preserve original numbers, units and research exposure only. Distinguish first-day glucose/insulin iAUC from next-day null insulin, registered AUC from reported iAUC, 22 participants in Henson’s incomplete crossover from 60 older adults analyzed by Yates, and static standing from walking and long-term desk questions. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, exercise/standing instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Existing bilingual claims/notes and the scope of historical checks must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original-text, translation, correction and claim-boundary review records. Historical checking language is not relabeled as completed current content review. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Original bilingual claims/notes and the parent’s historical account of checking two original trials, registries and overlap with 2245 are preserved. Citation statements that findings were checked are historical, not completion of new clinical review, registry verification or independent validation here.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Original-text, translation, correction and claim-boundary review records. Historical checking language is not relabeled as completed current content review.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original-text, translation, correction and claim-boundary review records. Historical checking language is not relabeled as completed current content review."
    },
    {
      "item_id": "N21",
      "question_type": "Evidence condition",
      "question": "Are subclaim values separated from parent grade/axes?",
      "needed": "Original subclaim grade, absent values and parent C54 context",
      "role": "Required",
      "role_reason": "This condition connects Original subclaim grade, absent values and parent C54 context with same-day iAUC in selected women, static standing versus walking, populations, direct comparators, condition-specific denominators, next-day/long-term boundaries, registration, support and harms.",
      "application_exception": "Preserve original numbers, units and research exposure only. Distinguish first-day glucose/insulin iAUC from next-day null insulin, registered AUC from reported iAUC, 22 participants in Henson’s incomplete crossover from 60 older adults analyzed by Yates, and static standing from walking and long-term desk questions. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, exercise/standing instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Original subclaim grade, absent values and parent C54 context must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original selected-subclaim/parent values and boundary checks. No new scores, axes, grades or efficacy reassessment are made. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Original subclaim grade C and its note are retained; subclaim score, safety and axes remain unrecorded. Parent C54/Unknown and B/S/R0/I2/E+/B2/CX are parent context, not a subclaim score, safety rating or independence certification.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Original selected-subclaim/parent values and boundary checks. No new scores, axes, grades or efficacy reassessment are made.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original selected-subclaim/parent values and boundary checks. No new scores, axes, grades or efficacy reassessment are made."
    },
    {
      "item_id": "N22",
      "question_type": "Evidence condition",
      "question": "Are evidence date, corrections and production date distinguished?",
      "needed": "Original evidence date and empty correction/deliberation records",
      "role": "Required",
      "role_reason": "This condition connects Original evidence date and empty correction/deliberation records with same-day iAUC in selected women, static standing versus walking, populations, direct comparators, condition-specific denominators, next-day/long-term boundaries, registration, support and harms.",
      "application_exception": "Preserve original numbers, units and research exposure only. Distinguish first-day glucose/insulin iAUC from next-day null insulin, registered AUC from reported iAUC, 22 participants in Henson’s incomplete crossover from 60 older adults analyzed by Yates, and static standing from walking and long-term desk questions. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, exercise/standing instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Original evidence date and empty correction/deliberation records must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Actual corrections, follow-up materials and complete pre-change history. Original dates and empty arrays are not filled arbitrarily. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Original evidence date 2026-09-07, an empty corrections array and an empty deliberation string are preserved. This is not the current production/content-review date; empty records do not certify that no external corrections exist.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Actual corrections, follow-up materials and complete pre-change history. Original dates and empty arrays are not filled arbitrarily.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Actual corrections, follow-up materials and complete pre-change history. Original dates and empty arrays are not filled arbitrarily."
    },
    {
      "item_id": "N23",
      "question_type": "Evidence condition",
      "question": "Are public funding and company involvement distinguished?",
      "needed": "Funding, product support, employee authors and analysis/reporting roles",
      "role": "Required",
      "role_reason": "This condition connects Funding, product support, employee authors and analysis/reporting roles with same-day iAUC in selected women, static standing versus walking, populations, direct comparators, condition-specific denominators, next-day/long-term boundaries, registration, support and harms.",
      "application_exception": "Preserve original numbers, units and research exposure only. Distinguish first-day glucose/insulin iAUC from next-day null insulin, registered AUC from reported iAUC, 22 participants in Henson’s incomplete crossover from 60 older adults analyzed by Yates, and static standing from walking and long-term desk questions. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, exercise/standing instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Funding, product support, employee authors and analysis/reporting roles must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original funding/COI, equipment/product support, author affiliations and analysis/publication roles. Parent I2 is not elevated into current independence certification. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Original funding is university/NIHR/NHS for Henson and UK public/university support for Yates. Public funding does not establish that product support, company employee authors or company analysis/reporting involvement are fully verified.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Original funding/COI, equipment/product support, author affiliations and analysis/publication roles. Parent I2 is not elevated into current independence certification.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original funding/COI, equipment/product support, author affiliations and analysis/publication roles. Parent I2 is not elevated into current independence certification."
    },
    {
      "item_id": "N24",
      "question_type": "Evidence condition",
      "question": "Are acute-crossover bias details verified?",
      "needed": "Allocation, order, measurement, missing data and selective reporting",
      "role": "Required",
      "role_reason": "This condition connects Allocation, order, measurement, missing data and selective reporting with same-day iAUC in selected women, static standing versus walking, populations, direct comparators, condition-specific denominators, next-day/long-term boundaries, registration, support and harms.",
      "application_exception": "Preserve original numbers, units and research exposure only. Distinguish first-day glucose/insulin iAUC from next-day null insulin, registered AUC from reported iAUC, 22 participants in Henson’s incomplete crossover from 60 older adults analyzed by Yates, and static standing from walking and long-term desk questions. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, exercise/standing instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Allocation, order, measurement, missing data and selective reporting must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original methods, registration, protocol, SAP, repeated-measures models, valid values/denominators and reporting changes. A design label does not establish official RoB/GRADE assessment or a passed content review. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Randomized acute incomplete-crossover/crossover design labels are preserved. Details of condition order, washout, period effects, allocation concealment, assessors, meal/measurement standardization, missing data and selective reporting are unverified.",
      "condition_status": "Unverified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Original methods, registration, protocol, SAP, repeated-measures models, valid values/denominators and reporting changes. A design label does not establish official RoB/GRADE assessment or a passed content review.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original methods, registration, protocol, SAP, repeated-measures models, valid values/denominators and reporting changes. A design label does not establish official RoB/GRADE assessment or a passed content review."
    },
    {
      "item_id": "N25",
      "question_type": "Evidence condition",
      "question": "Are actual standing exposure and concurrent activity known?",
      "needed": "Original protocol versus actual adherence/activity records",
      "role": "Required",
      "role_reason": "This condition connects Original protocol versus actual adherence/activity records with same-day iAUC in selected women, static standing versus walking, populations, direct comparators, condition-specific denominators, next-day/long-term boundaries, registration, support and harms.",
      "application_exception": "Preserve original numbers, units and research exposure only. Distinguish first-day glucose/insulin iAUC from next-day null insulin, registered AUC from reported iAUC, 22 participants in Henson’s incomplete crossover from 60 older adults analyzed by Yates, and static standing from walking and long-term desk questions. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, exercise/standing instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Original protocol versus actual adherence/activity records must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original exposure, activity, meal, measurement and adherence records. No new frequency/exposure totals or standing/exercise instructions are created. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The original 7.5 hours, five minutes every 30 minutes and total of 60 minutes of static standing are preserved only for research identification. Condition-specific actual adherence, movement, meals, concurrent activity and valid measurement denominators are unverified.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Original exposure, activity, meal, measurement and adherence records. No new frequency/exposure totals or standing/exercise instructions are created.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original exposure, activity, meal, measurement and adherence records. No new frequency/exposure totals or standing/exercise instructions are created."
    },
    {
      "item_id": "N26",
      "question_type": "Evidence condition",
      "question": "Are unknown safety and harm collection distinguished?",
      "needed": "Systematic harm collection, exposure, comparator and denominators",
      "role": "Supplementary",
      "role_reason": "This condition connects Systematic harm collection, exposure, comparator and denominators with same-day iAUC in selected women, static standing versus walking, populations, direct comparators, condition-specific denominators, next-day/long-term boundaries, registration, support and harms.",
      "application_exception": "Preserve original numbers, units and research exposure only. Distinguish first-day glucose/insulin iAUC from next-day null insulin, registered AUC from reported iAUC, 22 participants in Henson’s incomplete crossover from 60 older adults analyzed by Yates, and static standing from walking and long-term desk questions. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, exercise/standing instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Systematic harm collection, exposure, comparator and denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Adverse-event definitions, collection methods, group-specific exposure/denominators, withdrawals, severity and harm results. Unknown is not changed to safe or zero events. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Parent safety status is Unknown. The original safety explanation records that systematic adverse-event rates in the acute metabolic trials were unavailable. No new harm rates, event counts or between-condition CIs were verified here.",
      "condition_status": "Unverified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Adverse-event definitions, collection methods, group-specific exposure/denominators, withdrawals, severity and harm results. Unknown is not changed to safe or zero events.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Adverse-event definitions, collection methods, group-specific exposure/denominators, withdrawals, severity and harm results. Unknown is not changed to safe or zero events."
    },
    {
      "item_id": "N27",
      "question_type": "Evidence condition",
      "question": "What about selected participants able to stand and long-term harms?",
      "needed": "Orthostatic, vascular/musculoskeletal conditions and long-term boundaries",
      "role": "Supplementary",
      "role_reason": "This condition connects Orthostatic, vascular/musculoskeletal conditions and long-term boundaries with same-day iAUC in selected women, static standing versus walking, populations, direct comparators, condition-specific denominators, next-day/long-term boundaries, registration, support and harms.",
      "application_exception": "Preserve original numbers, units and research exposure only. Distinguish first-day glucose/insulin iAUC from next-day null insulin, registered AUC from reported iAUC, 22 participants in Henson’s incomplete crossover from 60 older adults analyzed by Yates, and static standing from walking and long-term desk questions. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, exercise/standing instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Orthostatic, vascular/musculoskeletal conditions and long-term boundaries must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Selection/exclusion criteria, comorbidities, harm surveillance, long-term exposure/denominators and actual follow-up. No new standing, exercise or treatment methods are written. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The original account says findings in selected participants able to stand cannot be generalized directly to people with orthostatic intolerance or vascular/musculoskeletal conditions. Rare harms and long-term risks are not established by the acute summary.",
      "condition_status": "Unverified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Selection/exclusion criteria, comorbidities, harm surveillance, long-term exposure/denominators and actual follow-up. No new standing, exercise or treatment methods are written.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Selection/exclusion criteria, comorbidities, harm surveillance, long-term exposure/denominators and actual follow-up. No new standing, exercise or treatment methods are written."
    },
    {
      "item_id": "N28",
      "question_type": "Evidence condition",
      "question": "Which materials would trigger an update?",
      "needed": "Separating source materials, applied conditions, observations and verdict changes",
      "role": "Required",
      "role_reason": "This condition connects Separating source materials, applied conditions, observations and verdict changes with same-day iAUC in selected women, static standing versus walking, populations, direct comparators, condition-specific denominators, next-day/long-term boundaries, registration, support and harms.",
      "application_exception": "Preserve original numbers, units and research exposure only. Distinguish first-day glucose/insulin iAUC from next-day null insulin, registered AUC from reported iAUC, 22 participants in Henson’s incomplete crossover from 60 older adults analyzed by Yates, and static standing from walking and long-term desk questions. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, exercise/standing instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Separating source materials, applied conditions, observations and verdict changes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Complete pre-change preservation, material/condition versions, separate application and review records. No new calculations, grades, independence certification or standing/exercise, medication-change or treatment guidance are created. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "This sheet transfers existing same-day iAUC content. Related observations can be updated when selected-subclaim/parent boundaries and original endpoint, timing, comparator, condition-specific denominator, registration, funding, shared-report and harm materials are verified.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Complete pre-change preservation, material/condition versions, separate application and review records. No new calculations, grades, independence certification or standing/exercise, medication-change or treatment guidance are created.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Complete pre-change preservation, material/condition versions, separate application and review records. No new calculations, grades, independence certification or standing/exercise, medication-change or treatment guidance are created."
    }
  ],
  "reports": [
    {
      "report_id": "R01",
      "title": "Henson J et al. Breaking Up Prolonged Sitting With Standing or Walking Attenuates the Postprandial Metabolic Response in Postmenopausal Women: A Randomized Acute Study. Diabetes Care. 2016;39(1):130-138. PMID: 26628415. DOI: 10.2337/dc15-1240. NCT02135172.",
      "url": "https://pubmed.ncbi.nlm.nih.gov/26628415/",
      "report_type": "Randomized acute incomplete-crossover trial",
      "existence": "Report linked in the original parent stored summary evidence/citation lists. External public availability, access and current acquisition of the original are unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "study_family": "Shared preserved Henson/Yates report context; cohort relationships, unique counts and independence unverified",
      "independent_replication": "Parent 2995 and both subclaim sheets share these reports. The same research team, crossover conditions and measurement days are not counted as new independent trials; unique-trial and participant totals are unverified.",
      "observed_result": "glucose iAUC −34%, P=.022; insulin iAUC −20%, P=.045",
      "result_level": "Positive first-day report in selected overweight or obese postmenopausal women with dysglycemia. The 22 participants experienced two of three conditions; this is not a denominator completing every condition. Next-day insulin was null; next-day glucose, direct CIs, the meaning of ± and condition-specific analysis denominators are unverified.",
      "source_evidence_date": "2026-09-07",
      "materials": [
        {
          "material_type": "Stored existing review summary",
          "public_status": "Preserved copy of the complete parent-verdict stored summary",
          "access_status": "Stored summary",
          "acquired": true,
          "actually_read": "Summary read",
          "as_of": "2026-09-07",
          "qualification": "Preserve the original PubMed URL, PMID 26628415, DOI 10.2337/dc15-1240, citation NCT02135172 and retrospective-registration flag. A separate evidence nct field and PMCID are unrecorded. Registered-primary AUC is original wording; registration contents, dates, prospective status and plan adherence are unverified in this work."
        },
        {
          "material_type": "External abstract",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": null,
          "qualification": "Preserve the original PubMed URL, PMID 26628415, DOI 10.2337/dc15-1240, citation NCT02135172 and retrospective-registration flag. A separate evidence nct field and PMCID are unrecorded. Registered-primary AUC is original wording; registration contents, dates, prospective status and plan adherence are unverified in this work."
        },
        {
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      "title": "Yates T et al. Metabolic Effects of Breaking Prolonged Sitting With Standing or Light Walking in Older South Asians and White Europeans: A Randomized Acute Study. J Gerontol A Biol Sci Med Sci. 2020;75(1):139-146. PMID: 30403772. PMCID: PMC6909896. DOI: 10.1093/gerona/gly252. NCT02453204.",
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      "study_family": "Shared preserved Henson/Yates report context; cohort relationships, unique counts and independence unverified",
      "independent_replication": "Parent 2995 and both subclaim sheets share these reports. The same research team, crossover conditions and measurement days are not counted as new independent trials; unique-trial and participant totals are unverified.",
      "observed_result": "Standing versus uninterrupted sitting was null for primary insulin and glucose",
      "result_level": "Conflicting report in a different older population with 60 analyzed. Preserve South Asians/White Europeans from the original bibliography. Exact effects, CIs, P values, condition-specific denominators and models are unverified; results are not copied into the selected women’s effect or interpreted as zero effect or equivalence.",
      "source_evidence_date": "2026-09-07",
      "materials": [
        {
          "material_type": "Stored existing review summary",
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        {
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        },
        {
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        }
      ],
      "links": [
        {
          "label": "PubMed",
          "url": "https://pubmed.ncbi.nlm.nih.gov/30403772/"
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  ],
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      "id": "M03",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03",
      "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13",
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      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
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      "id": "M04",
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      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04",
      "section": "§4.5, §4.6.1–4.6.3, MECIR C42",
      "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M08",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08",
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      "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M15",
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      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15",
      "section": "§15.2.4, §15.3.1–15.3.3",
      "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M19",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19",
      "section": "§19.1.2, §19.2.1–19.2.4",
      "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    }
  ],
  "status_dictionary": {
    "Partly verified": "Some information is present in the stored source, with detailed original materials still unverified; this does not mean review passed or clinical efficacy certified",
    "Unverified": "Detailed materials for the selected condition could not be established within the stored scope; this does not mean zero effect, zero studies or safety",
    "Review incomplete": "Awaiting user review",
    "Met": "Use only within the relevant condition's scope after user review; no automatic display in this preparation",
    "Not reported": "Distinguish only within materials actually read; do not turn unread external materials into unreported findings",
    "Inaccessible": "Not applied during this preparation because actual access was not tested",
    "Not applicable": "Use with a reason for non-applicability based on an explicit question boundary",
    "Conflicting data": "Judge after actual material comparison; review was not performed during this preparation",
    "Insufficient evidence for the conditions": "Do not use as a clinical grade encompassing currently unread materials"
  },
  "study_overlap": {
    "state": "Unverified",
    "unique_trial_count": null,
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    "reason": "Parent 2995 and the same-day/long-term subclaim sheets share the preserved Henson/Yates report context. The same research team, two citations, crossover conditions and measurement days are not counted as new independent trials or participants. The 22 Henson participants and 60 analyzed by Yates are not summed; unique-trial/participant totals and cohort overlap are unverified."
  },
  "history": [
    {
      "date": "2026-10-16",
      "kind": "Separation of public-facing pages and materials",
      "view_version": "1.0",
      "change": "Public reader pages and material were prepared from the existing 28 items. No new clinical searches, verification-state changes or scoring were performed."
    }
  ],
  "language": "en",
  "translation_date": "2026-10-16"
}