{
  "schema_version": "chamgap-public-criteria-1.0",
  "title": "Static standing × same-day iAUC in selected women",
  "language": "en",
  "translation_date": "2026-10-16",
  "criteria_version": "1.0",
  "criteria_date": "2026-10-06",
  "condition_origin": "Chamgap's own application conditions",
  "method_sources": [
    {
      "id": "M03",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03",
      "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13",
      "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M04",
      "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04",
      "section": "§4.5, §4.6.1–4.6.3, MECIR C42",
      "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M08",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08",
      "section": "§8.1–8.2.3, Table 8.2.a",
      "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M15",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15",
      "section": "§15.2.4, §15.3.1–15.3.3",
      "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M19",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19",
      "section": "§19.1.2, §19.2.1–19.2.4",
      "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    }
  ],
  "status_dictionary": {
    "Partly verified": "Some information is present in the stored source, with detailed original materials still unverified; this does not mean review passed or clinical efficacy certified",
    "Unverified": "Detailed materials for the selected condition could not be established within the stored scope; this does not mean zero effect, zero studies or safety",
    "Review incomplete": "Awaiting user review",
    "Met": "Use only within the relevant condition's scope after user review; no automatic display in this preparation",
    "Not reported": "Distinguish only within materials actually read; do not turn unread external materials into unreported findings",
    "Inaccessible": "Not applied during this preparation because actual access was not tested",
    "Not applicable": "Use with a reason for non-applicability based on an explicit question boundary",
    "Conflicting data": "Judge after actual material comparison; review was not performed during this preparation",
    "Insufficient evidence for the conditions": "Do not use as a clinical grade encompassing currently unread materials"
  },
  "requirements": [
    {
      "item_id": "N01",
      "question_type": "Evidence condition",
      "question": "Which same-day iAUC claim is being checked?",
      "needed": "Same-day postprandial iAUC in selected overweight women",
      "role": "Required",
      "role_reason": "This condition connects Same-day postprandial iAUC in selected overweight women with same-day iAUC in selected women, static standing versus walking, populations, direct comparators, condition-specific denominators, next-day/long-term boundaries, registration, support and harms.",
      "application_exception": "Preserve original numbers, units and research exposure only. Distinguish first-day glucose/insulin iAUC from next-day null insulin, registered AUC from reported iAUC, 22 participants in Henson’s incomplete crossover from 60 older adults analyzed by Yates, and static standing from walking and long-term desk questions. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, exercise/standing instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Same-day postprandial iAUC in selected overweight women must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original materials identifying the selected population, static standing, comparator, endpoint/time and claim boundaries. The parent score is not used to fill the absent subclaim score. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N02",
      "question_type": "Evidence condition",
      "question": "Who comprised the positive sample?",
      "needed": "Overweight or obese postmenopausal women with dysglycemia",
      "role": "Required",
      "role_reason": "This condition connects Overweight or obese postmenopausal women with dysglycemia with same-day iAUC in selected women, static standing versus walking, populations, direct comparators, condition-specific denominators, next-day/long-term boundaries, registration, support and harms.",
      "application_exception": "Preserve original numbers, units and research exposure only. Distinguish first-day glucose/insulin iAUC from next-day null insulin, registered AUC from reported iAUC, 22 participants in Henson’s incomplete crossover from 60 older adults analyzed by Yates, and static standing from walking and long-term desk questions. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, exercise/standing instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Overweight or obese postmenopausal women with dysglycemia must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original eligibility, menopause/glycemia criteria, baseline glucose, medications, comorbidities, ability-to-stand criteria and subgroup denominators. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N03",
      "question_type": "Evidence condition",
      "question": "What was the first-day glucose iAUC result?",
      "needed": "Henson first-day glucose iAUC and direct comparison",
      "role": "Required",
      "role_reason": "This condition connects Henson first-day glucose iAUC and direct comparison with same-day iAUC in selected women, static standing versus walking, populations, direct comparators, condition-specific denominators, next-day/long-term boundaries, registration, support and harms.",
      "application_exception": "Preserve original numbers, units and research exposure only. Distinguish first-day glucose/insulin iAUC from next-day null insulin, registered AUC from reported iAUC, 22 participants in Henson’s incomplete crossover from 60 older adults analyzed by Yates, and static standing from walking and long-term desk questions. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, exercise/standing instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Henson first-day glucose iAUC and direct comparison must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: iAUC baseline/integration interval, model, condition-specific analysis denominators, direct between-condition estimate/CI and the meaning of ±. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N04",
      "question_type": "Evidence condition",
      "question": "Is first-day insulin iAUC a separate endpoint?",
      "needed": "Henson first-day insulin iAUC",
      "role": "Required",
      "role_reason": "This condition connects Henson first-day insulin iAUC with same-day iAUC in selected women, static standing versus walking, populations, direct comparators, condition-specific denominators, next-day/long-term boundaries, registration, support and harms.",
      "application_exception": "Preserve original numbers, units and research exposure only. Distinguish first-day glucose/insulin iAUC from next-day null insulin, registered AUC from reported iAUC, 22 participants in Henson’s incomplete crossover from 60 older adults analyzed by Yates, and static standing from walking and long-term desk questions. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, exercise/standing instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Henson first-day insulin iAUC must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Insulin iAUC definition, original curves, model, denominators, direct CI, meaning of ±, endpoint hierarchy and relationship to glucose. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N05",
      "question_type": "Evidence condition",
      "question": "Were next-day findings the same?",
      "needed": "First-day positive findings versus null next-day insulin",
      "role": "Required",
      "role_reason": "This condition connects First-day positive findings versus null next-day insulin with same-day iAUC in selected women, static standing versus walking, populations, direct comparators, condition-specific denominators, next-day/long-term boundaries, registration, support and harms.",
      "application_exception": "Preserve original numbers, units and research exposure only. Distinguish first-day glucose/insulin iAUC from next-day null insulin, registered AUC from reported iAUC, 22 participants in Henson’s incomplete crossover from 60 older adults analyzed by Yates, and static standing from walking and long-term desk questions. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, exercise/standing instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for First-day positive findings versus null next-day insulin must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Next-day conditions, denominators, effects, CIs, P values and original tables for each endpoint. Null findings do not establish zero difference or absence of long-term effects. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N06",
      "question_type": "Evidence condition",
      "question": "What did the related older-adult trial find for standing alone?",
      "needed": "Primary insulin and glucose in the 60 analyzed by Yates",
      "role": "Required",
      "role_reason": "This condition connects Primary insulin and glucose in the 60 analyzed by Yates with same-day iAUC in selected women, static standing versus walking, populations, direct comparators, condition-specific denominators, next-day/long-term boundaries, registration, support and harms.",
      "application_exception": "Preserve original numbers, units and research exposure only. Distinguish first-day glucose/insulin iAUC from next-day null insulin, registered AUC from reported iAUC, 22 participants in Henson’s incomplete crossover from 60 older adults analyzed by Yates, and static standing from walking and long-term desk questions. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, exercise/standing instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Primary insulin and glucose in the 60 analyzed by Yates must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original result tables, primary-endpoint hierarchy, population/condition denominators, effects, CIs, P values and missing data. Null findings do not prove zero effect or equivalence. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N07",
      "question_type": "Evidence condition",
      "question": "How are standing and walking separated?",
      "needed": "Activity type, direct comparisons and equivalence boundaries",
      "role": "Required",
      "role_reason": "This condition connects Activity type, direct comparisons and equivalence boundaries with same-day iAUC in selected women, static standing versus walking, populations, direct comparators, condition-specific denominators, next-day/long-term boundaries, registration, support and harms.",
      "application_exception": "Preserve original numbers, units and research exposure only. Distinguish first-day glucose/insulin iAUC from next-day null insulin, registered AUC from reported iAUC, 22 participants in Henson’s incomplete crossover from 60 older adults analyzed by Yates, and static standing from walking and long-term desk questions. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, exercise/standing instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Activity type, direct comparisons and equivalence boundaries must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Activity-specific direct comparisons, effects/CIs, prespecified equivalence criteria, denominators and actual activity records. No new activity instructions are written. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N08",
      "question_type": "Evidence condition",
      "question": "What was the original static-standing exposure?",
      "needed": "Identification of motionless standing, laboratory day and comparator",
      "role": "Required",
      "role_reason": "This condition connects Identification of motionless standing, laboratory day and comparator with same-day iAUC in selected women, static standing versus walking, populations, direct comparators, condition-specific denominators, next-day/long-term boundaries, registration, support and harms.",
      "application_exception": "Preserve original numbers, units and research exposure only. Distinguish first-day glucose/insulin iAUC from next-day null insulin, registered AUC from reported iAUC, 22 participants in Henson’s incomplete crossover from 60 older adults analyzed by Yates, and static standing from walking and long-term desk questions. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, exercise/standing instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Identification of motionless standing, laboratory day and comparator must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Actual protocol, movement/standing verification, meals, concurrent activity, adherence and exposure data. Height-adjustable desks and walking are not substituted. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N09",
      "question_type": "Evidence condition",
      "question": "Did all 22 participants complete every condition?",
      "needed": "Incomplete crossover and condition-specific analysis denominators",
      "role": "Required",
      "role_reason": "This condition connects Incomplete crossover and condition-specific analysis denominators with same-day iAUC in selected women, static standing versus walking, populations, direct comparators, condition-specific denominators, next-day/long-term boundaries, registration, support and harms.",
      "application_exception": "Preserve original numbers, units and research exposure only. Distinguish first-day glucose/insulin iAUC from next-day null insulin, registered AUC from reported iAUC, 22 participants in Henson’s incomplete crossover from 60 older adults analyzed by Yates, and static standing from walking and long-term desk questions. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, exercise/standing instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Incomplete crossover and condition-specific analysis denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Condition combinations/order, washout, period effects, valid condition-specific denominators and allocation/analysis flow. Repeated crossover observations are not counted as additional participants. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N10",
      "question_type": "Evidence condition",
      "question": "Do registered AUC and reported iAUC have matching definitions?",
      "needed": "AUC/iAUC wording and endpoint definitions",
      "role": "Required",
      "role_reason": "This condition connects AUC/iAUC wording and endpoint definitions with same-day iAUC in selected women, static standing versus walking, populations, direct comparators, condition-specific denominators, next-day/long-term boundaries, registration, support and harms.",
      "application_exception": "Preserve original numbers, units and research exposure only. Distinguish first-day glucose/insulin iAUC from next-day null insulin, registered AUC from reported iAUC, 22 participants in Henson’s incomplete crossover from 60 older adults analyzed by Yates, and static standing from walking and long-term desk questions. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, exercise/standing instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for AUC/iAUC wording and endpoint definitions must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original registered endpoint, AUC/iAUC definitions, baseline/negative-area handling, SAP and analysis tables. No arbitrary terminology correction or new discrepancy verdict is created. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N11",
      "question_type": "Evidence condition",
      "question": "Were the positive and null populations identical?",
      "needed": "Selected women versus a different older population",
      "role": "Required",
      "role_reason": "This condition connects Selected women versus a different older population with same-day iAUC in selected women, static standing versus walking, populations, direct comparators, condition-specific denominators, next-day/long-term boundaries, registration, support and harms.",
      "application_exception": "Preserve original numbers, units and research exposure only. Distinguish first-day glucose/insulin iAUC from next-day null insulin, registered AUC from reported iAUC, 22 participants in Henson’s incomplete crossover from 60 older adults analyzed by Yates, and static standing from walking and long-term desk questions. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, exercise/standing instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Selected women versus a different older population must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Report-specific eligibility, sex, age, glycemia, ethnic background, baseline values, denominators and prespecified effect-modification analyses. Conflicting directions and parent R0 are retained. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N12",
      "question_type": "Evidence condition",
      "question": "Are registered-primary and retrospective-registration statements distinguished?",
      "needed": "Registry identifiers, timing, prospective status and endpoint hierarchy",
      "role": "Required",
      "role_reason": "This condition connects Registry identifiers, timing, prospective status and endpoint hierarchy with same-day iAUC in selected women, static standing versus walking, populations, direct comparators, condition-specific denominators, next-day/long-term boundaries, registration, support and harms.",
      "application_exception": "Preserve original numbers, units and research exposure only. Distinguish first-day glucose/insulin iAUC from next-day null insulin, registered AUC from reported iAUC, 22 participants in Henson’s incomplete crossover from 60 older adults analyzed by Yates, and static standing from walking and long-term desk questions. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, exercise/standing instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Registry identifiers, timing, prospective status and endpoint hierarchy must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Initial/changed registration dates, protocols, SAPs, actual start/result-report dates and endpoint hierarchy. Registered-primary wording alone does not certify preregistration or plan adherence. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N13",
      "question_type": "Evidence condition",
      "question": "Are direct CIs and the meaning of ± available?",
      "needed": "Effect intervals and variation definitions for each endpoint/time/contrast",
      "role": "Required",
      "role_reason": "This condition connects Effect intervals and variation definitions for each endpoint/time/contrast with same-day iAUC in selected women, static standing versus walking, populations, direct comparators, condition-specific denominators, next-day/long-term boundaries, registration, support and harms.",
      "application_exception": "Preserve original numbers, units and research exposure only. Distinguish first-day glucose/insulin iAUC from next-day null insulin, registered AUC from reported iAUC, 22 participants in Henson’s incomplete crossover from 60 older adults analyzed by Yates, and static standing from walking and long-term desk questions. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, exercise/standing instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Effect intervals and variation definitions for each endpoint/time/contrast must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original model, effect estimator, variation definitions, direct CIs and condition-specific measurements/denominators. No new absolute differences, CIs or relative effects are calculated. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N14",
      "question_type": "Evidence condition",
      "question": "What is the clinical meaning of same-day iAUC?",
      "needed": "Acute metabolic measures versus long-term clinical importance",
      "role": "Required",
      "role_reason": "This condition connects Acute metabolic measures versus long-term clinical importance with same-day iAUC in selected women, static standing versus walking, populations, direct comparators, condition-specific denominators, next-day/long-term boundaries, registration, support and harms.",
      "application_exception": "Preserve original numbers, units and research exposure only. Distinguish first-day glucose/insulin iAUC from next-day null insulin, registered AUC from reported iAUC, 22 participants in Henson’s incomplete crossover from 60 older adults analyzed by Yates, and static standing from walking and long-term desk questions. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, exercise/standing instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Acute metabolic measures versus long-term clinical importance must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Clinical-importance criteria for the selected population and direct long-term endpoints. No hypothetical glucose-change or risk-reduction examples are created. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N15",
      "question_type": "Evidence condition",
      "question": "Were long-term HbA1c or complications measured?",
      "needed": "Boundaries on extending the same-day question",
      "role": "Required",
      "role_reason": "This condition connects Boundaries on extending the same-day question with same-day iAUC in selected women, static standing versus walking, populations, direct comparators, condition-specific denominators, next-day/long-term boundaries, registration, support and harms.",
      "application_exception": "Preserve original numbers, units and research exposure only. Distinguish first-day glucose/insulin iAUC from next-day null insulin, registered AUC from reported iAUC, 22 participants in Henson’s incomplete crossover from 60 older adults analyzed by Yates, and static standing from walking and long-term desk questions. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, exercise/standing instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Boundaries on extending the same-day question must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Direct long-term HbA1c/complication definitions, duration, group-specific denominators, effects and CIs. Nonmeasurement does not certify no effect or the absence of all long-term research. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N16",
      "question_type": "Evidence condition",
      "question": "Is this the same as the eight-week adjustable-desk question?",
      "needed": "Original verdict 2245 reference and protocol/endpoint differences",
      "role": "Required",
      "role_reason": "This condition connects Original verdict 2245 reference and protocol/endpoint differences with same-day iAUC in selected women, static standing versus walking, populations, direct comparators, condition-specific denominators, next-day/long-term boundaries, registration, support and harms.",
      "application_exception": "Preserve original numbers, units and research exposure only. Distinguish first-day glucose/insulin iAUC from next-day null insulin, registered AUC from reported iAUC, 22 participants in Henson’s incomplete crossover from 60 older adults analyzed by Yates, and static standing from walking and long-term desk questions. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, exercise/standing instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Original verdict 2245 reference and protocol/endpoint differences must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Materials comparing those questions with the original protocols/endpoints. Desk installation or long-term management is not treated as a same-day static-standing effect. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N17",
      "question_type": "Evidence condition",
      "question": "Are shared reports counted as independent trials?",
      "needed": "Reports, cohorts, selected questions and repeated measurements",
      "role": "Required",
      "role_reason": "This condition connects Reports, cohorts, selected questions and repeated measurements with same-day iAUC in selected women, static standing versus walking, populations, direct comparators, condition-specific denominators, next-day/long-term boundaries, registration, support and harms.",
      "application_exception": "Preserve original numbers, units and research exposure only. Distinguish first-day glucose/insulin iAUC from next-day null insulin, registered AUC from reported iAUC, 22 participants in Henson’s incomplete crossover from 60 older adults analyzed by Yates, and static standing from walking and long-term desk questions. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, exercise/standing instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Reports, cohorts, selected questions and repeated measurements must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Report/cohort identities, incomplete-crossover conditions, shared researchers and analysis-population relationships. Unique counts and independence remain unverified. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N18",
      "question_type": "Evidence condition",
      "question": "Which materials were actually read?",
      "needed": "Stored summaries versus external originals and registration",
      "role": "Required",
      "role_reason": "This condition connects Stored summaries versus external originals and registration with same-day iAUC in selected women, static standing versus walking, populations, direct comparators, condition-specific denominators, next-day/long-term boundaries, registration, support and harms.",
      "application_exception": "Preserve original numbers, units and research exposure only. Distinguish first-day glucose/insulin iAUC from next-day null insulin, registered AUC from reported iAUC, 22 participants in Henson’s incomplete crossover from 60 older adults analyzed by Yates, and static standing from walking and long-term desk questions. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, exercise/standing instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Stored summaries versus external originals and registration must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Actual acquisition/reading records for originals, appendices, plans and registration. No new external retrieval or access attempt was made in this work. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N19",
      "question_type": "Evidence condition",
      "question": "Where are bibliographic and registration identifiers recorded?",
      "needed": "DOI, PMID, PMCID and NCT in original citations",
      "role": "Required",
      "role_reason": "This condition connects DOI, PMID, PMCID and NCT in original citations with same-day iAUC in selected women, static standing versus walking, populations, direct comparators, condition-specific denominators, next-day/long-term boundaries, registration, support and harms.",
      "application_exception": "Preserve original numbers, units and research exposure only. Distinguish first-day glucose/insulin iAUC from next-day null insulin, registered AUC from reported iAUC, 22 participants in Henson’s incomplete crossover from 60 older adults analyzed by Yates, and static standing from walking and long-term desk questions. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, exercise/standing instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for DOI, PMID, PMCID and NCT in original citations must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original materials linking report and registration contents/timing. No new URLs are inferred from identifiers; original citation locations and wording are preserved. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N20",
      "question_type": "Evidence condition",
      "question": "Are historical bilingual checks distinguished from this work?",
      "needed": "Existing bilingual claims/notes and the scope of historical checks",
      "role": "Required",
      "role_reason": "This condition connects Existing bilingual claims/notes and the scope of historical checks with same-day iAUC in selected women, static standing versus walking, populations, direct comparators, condition-specific denominators, next-day/long-term boundaries, registration, support and harms.",
      "application_exception": "Preserve original numbers, units and research exposure only. Distinguish first-day glucose/insulin iAUC from next-day null insulin, registered AUC from reported iAUC, 22 participants in Henson’s incomplete crossover from 60 older adults analyzed by Yates, and static standing from walking and long-term desk questions. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, exercise/standing instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Existing bilingual claims/notes and the scope of historical checks must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original-text, translation, correction and claim-boundary review records. Historical checking language is not relabeled as completed current content review. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N21",
      "question_type": "Evidence condition",
      "question": "Are subclaim values separated from parent grade/axes?",
      "needed": "Original subclaim grade, absent values and parent C54 context",
      "role": "Required",
      "role_reason": "This condition connects Original subclaim grade, absent values and parent C54 context with same-day iAUC in selected women, static standing versus walking, populations, direct comparators, condition-specific denominators, next-day/long-term boundaries, registration, support and harms.",
      "application_exception": "Preserve original numbers, units and research exposure only. Distinguish first-day glucose/insulin iAUC from next-day null insulin, registered AUC from reported iAUC, 22 participants in Henson’s incomplete crossover from 60 older adults analyzed by Yates, and static standing from walking and long-term desk questions. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, exercise/standing instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Original subclaim grade, absent values and parent C54 context must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original selected-subclaim/parent values and boundary checks. No new scores, axes, grades or efficacy reassessment are made. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N22",
      "question_type": "Evidence condition",
      "question": "Are evidence date, corrections and production date distinguished?",
      "needed": "Original evidence date and empty correction/deliberation records",
      "role": "Required",
      "role_reason": "This condition connects Original evidence date and empty correction/deliberation records with same-day iAUC in selected women, static standing versus walking, populations, direct comparators, condition-specific denominators, next-day/long-term boundaries, registration, support and harms.",
      "application_exception": "Preserve original numbers, units and research exposure only. Distinguish first-day glucose/insulin iAUC from next-day null insulin, registered AUC from reported iAUC, 22 participants in Henson’s incomplete crossover from 60 older adults analyzed by Yates, and static standing from walking and long-term desk questions. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, exercise/standing instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Original evidence date and empty correction/deliberation records must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Actual corrections, follow-up materials and complete pre-change history. Original dates and empty arrays are not filled arbitrarily. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N23",
      "question_type": "Evidence condition",
      "question": "Are public funding and company involvement distinguished?",
      "needed": "Funding, product support, employee authors and analysis/reporting roles",
      "role": "Required",
      "role_reason": "This condition connects Funding, product support, employee authors and analysis/reporting roles with same-day iAUC in selected women, static standing versus walking, populations, direct comparators, condition-specific denominators, next-day/long-term boundaries, registration, support and harms.",
      "application_exception": "Preserve original numbers, units and research exposure only. Distinguish first-day glucose/insulin iAUC from next-day null insulin, registered AUC from reported iAUC, 22 participants in Henson’s incomplete crossover from 60 older adults analyzed by Yates, and static standing from walking and long-term desk questions. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, exercise/standing instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Funding, product support, employee authors and analysis/reporting roles must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original funding/COI, equipment/product support, author affiliations and analysis/publication roles. Parent I2 is not elevated into current independence certification. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N24",
      "question_type": "Evidence condition",
      "question": "Are acute-crossover bias details verified?",
      "needed": "Allocation, order, measurement, missing data and selective reporting",
      "role": "Required",
      "role_reason": "This condition connects Allocation, order, measurement, missing data and selective reporting with same-day iAUC in selected women, static standing versus walking, populations, direct comparators, condition-specific denominators, next-day/long-term boundaries, registration, support and harms.",
      "application_exception": "Preserve original numbers, units and research exposure only. Distinguish first-day glucose/insulin iAUC from next-day null insulin, registered AUC from reported iAUC, 22 participants in Henson’s incomplete crossover from 60 older adults analyzed by Yates, and static standing from walking and long-term desk questions. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, exercise/standing instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Allocation, order, measurement, missing data and selective reporting must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original methods, registration, protocol, SAP, repeated-measures models, valid values/denominators and reporting changes. A design label does not establish official RoB/GRADE assessment or a passed content review. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N25",
      "question_type": "Evidence condition",
      "question": "Are actual standing exposure and concurrent activity known?",
      "needed": "Original protocol versus actual adherence/activity records",
      "role": "Required",
      "role_reason": "This condition connects Original protocol versus actual adherence/activity records with same-day iAUC in selected women, static standing versus walking, populations, direct comparators, condition-specific denominators, next-day/long-term boundaries, registration, support and harms.",
      "application_exception": "Preserve original numbers, units and research exposure only. Distinguish first-day glucose/insulin iAUC from next-day null insulin, registered AUC from reported iAUC, 22 participants in Henson’s incomplete crossover from 60 older adults analyzed by Yates, and static standing from walking and long-term desk questions. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, exercise/standing instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Original protocol versus actual adherence/activity records must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original exposure, activity, meal, measurement and adherence records. No new frequency/exposure totals or standing/exercise instructions are created. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N26",
      "question_type": "Evidence condition",
      "question": "Are unknown safety and harm collection distinguished?",
      "needed": "Systematic harm collection, exposure, comparator and denominators",
      "role": "Supplementary",
      "role_reason": "This condition connects Systematic harm collection, exposure, comparator and denominators with same-day iAUC in selected women, static standing versus walking, populations, direct comparators, condition-specific denominators, next-day/long-term boundaries, registration, support and harms.",
      "application_exception": "Preserve original numbers, units and research exposure only. Distinguish first-day glucose/insulin iAUC from next-day null insulin, registered AUC from reported iAUC, 22 participants in Henson’s incomplete crossover from 60 older adults analyzed by Yates, and static standing from walking and long-term desk questions. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, exercise/standing instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Systematic harm collection, exposure, comparator and denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Adverse-event definitions, collection methods, group-specific exposure/denominators, withdrawals, severity and harm results. Unknown is not changed to safe or zero events. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N27",
      "question_type": "Evidence condition",
      "question": "What about selected participants able to stand and long-term harms?",
      "needed": "Orthostatic, vascular/musculoskeletal conditions and long-term boundaries",
      "role": "Supplementary",
      "role_reason": "This condition connects Orthostatic, vascular/musculoskeletal conditions and long-term boundaries with same-day iAUC in selected women, static standing versus walking, populations, direct comparators, condition-specific denominators, next-day/long-term boundaries, registration, support and harms.",
      "application_exception": "Preserve original numbers, units and research exposure only. Distinguish first-day glucose/insulin iAUC from next-day null insulin, registered AUC from reported iAUC, 22 participants in Henson’s incomplete crossover from 60 older adults analyzed by Yates, and static standing from walking and long-term desk questions. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, exercise/standing instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Orthostatic, vascular/musculoskeletal conditions and long-term boundaries must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Selection/exclusion criteria, comorbidities, harm surveillance, long-term exposure/denominators and actual follow-up. No new standing, exercise or treatment methods are written. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N28",
      "question_type": "Evidence condition",
      "question": "Which materials would trigger an update?",
      "needed": "Separating source materials, applied conditions, observations and verdict changes",
      "role": "Required",
      "role_reason": "This condition connects Separating source materials, applied conditions, observations and verdict changes with same-day iAUC in selected women, static standing versus walking, populations, direct comparators, condition-specific denominators, next-day/long-term boundaries, registration, support and harms.",
      "application_exception": "Preserve original numbers, units and research exposure only. Distinguish first-day glucose/insulin iAUC from next-day null insulin, registered AUC from reported iAUC, 22 participants in Henson’s incomplete crossover from 60 older adults analyzed by Yates, and static standing from walking and long-term desk questions. No new differences, CIs, totals, exposure calculations, grades, independence/equivalence certification, exercise/standing instructions, medication changes or treatment guidance are created.",
      "criterion": "Material for Separating source materials, applied conditions, observations and verdict changes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Complete pre-change preservation, material/condition versions, separate application and review records. No new calculations, grades, independence certification or standing/exercise, medication-change or treatment guidance are created. This records needed materials; no new research was executed."
    }
  ]
}