{ "schema_version": "chamgap-public-criteria-1.0", "title": "Ice-slurry precooling × heat-illness prevention: evidence gaps", "language": "en", "translation_date": "2026-10-16", "criteria_version": "1.0", "criteria_date": "2026-10-06", "condition_origin": "Chamgap's own application conditions", "method_sources": [ { "id": "M03", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03", "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13", "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.", "review_level": "Preserved method HTML copies; no current method-content re-review or official tool execution" }, { "id": "M04", "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04", "section": "§4.5, §4.6.1–4.6.3, MECIR C42", "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.", "review_level": "Preserved method HTML copies; no current method-content re-review or official tool execution" }, { "id": "M08", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08", "section": "§8.1–8.2.3, Table 8.2.a", "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.", "review_level": "Preserved method HTML copies; no current method-content re-review or official tool execution" }, { "id": "M15", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15", "section": "§15.2.4, §15.3.1–15.3.3", "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.", "review_level": "Preserved method HTML copies; no current method-content re-review or official tool execution" }, { "id": "M19", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19", "section": "§19.1.2, §19.2.1–19.2.4", "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.", "review_level": "Preserved method HTML copies; no current method-content re-review or official tool execution" } ], "status_dictionary": { "Met": "A state used when required evidence is confirmed after user review. This production does not declare that review complete.", "Partly verified": "Some information in the stored summary is linked into the table. External comparison/content review is not complete.", "Unverified": "The article leaves this unverified, or required material is absent from the current stored summary. This is distinct from zero, absence or safety.", "Review incomplete": "User review pending.", "Not reported": "Not reported within the stored material actually read; not extended to the entire primary paper.", "Inaccessible": "Means an actual access failure. Access not attempted here is not assigned this state.", "Not applicable": "Not used as a substitute for an evidence gap.", "Conflicting data": "Requires an observed disagreement under the same comparison criteria; not automatically judged in this production.", "Insufficient evidence for the conditions": "Marks a gap in additional material required by the selected conditions; not a new efficacy grade." }, "requirements": [ { "item_id": "N01", "question_type": "Evidence condition", "question": "What are the selected heat-illness-prevention question and original verdict?", "needed": "Prevention wording, note and grade versus the parent performance verdict", "role": "Required", "role_reason": "This condition connects Prevention wording, note and grade versus the parent performance verdict with the selected heat-illness-prevention question, unmeasured events, original ice slurry/cold water, within-person crossover, people/conditions, environment, time, temperature, denominators and harms.", "application_exception": "Preserve original numbers while distinguishing unmeasured prevention events and grade ? from acute running time and temperature. Distinguish single pre-exercise ice slurry/cold water, people/two conditions, different exhaustion times, pre-exercise/terminal times and laboratory/field settings. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or ingestion, product, exercise, cooling, prevention or treatment instructions are created.", "criterion": "Material for Prevention wording, note and grade versus the parent performance verdict must be linked to the selected subclaim, parent performance context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: The subclaim's own score, status, axes and direct prevention results are unrecorded. This records needed materials; no new research was executed." }, { "item_id": "N02", "question_type": "Evidence condition", "question": "Were heat-illness events actually measured?", "needed": "Clinical-event definitions, confirmation, denominators and occurrence results", "role": "Required", "role_reason": "This condition connects Clinical-event definitions, confirmation, denominators and occurrence results with the selected heat-illness-prevention question, unmeasured events, original ice slurry/cold water, within-person crossover, people/conditions, environment, time, temperature, denominators and harms.", "application_exception": "Preserve original numbers while distinguishing unmeasured prevention events and grade ? from acute running time and temperature. Distinguish single pre-exercise ice slurry/cold water, people/two conditions, different exhaustion times, pre-exercise/terminal times and laboratory/field settings. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or ingestion, product, exercise, cooling, prevention or treatment instructions are created.", "criterion": "Material for Clinical-event definitions, confirmation, denominators and occurrence results must be linked to the selected subclaim, parent performance context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Heat-illness definitions, clinical confirmation, event denominators, observation periods and comparative prevention effects are unverified. This records needed materials; no new research was executed." }, { "item_id": "N03", "question_type": "Evidence condition", "question": "Are participants distinguished from the two condition denominators?", "needed": "Eligibility, allocation, completion and analysis counts by condition", "role": "Required", "role_reason": "This condition connects Eligibility, allocation, completion and analysis counts by condition with the selected heat-illness-prevention question, unmeasured events, original ice slurry/cold water, within-person crossover, people/conditions, environment, time, temperature, denominators and harms.", "application_exception": "Preserve original numbers while distinguishing unmeasured prevention events and grade ? from acute running time and temperature. Distinguish single pre-exercise ice slurry/cold water, people/two conditions, different exhaustion times, pre-exercise/terminal times and laboratory/field settings. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or ingestion, product, exercise, cooling, prevention or treatment instructions are created.", "criterion": "Material for Eligibility, allocation, completion and analysis counts by condition must be linked to the selected subclaim, parent performance context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Detailed eligibility, age, allocation by sequence and completion/analysis counts by condition are unverified. This records needed materials; no new research was executed." }, { "item_id": "N04", "question_type": "Evidence condition", "question": "What was the original pre-exercise precooling exposure?", "needed": "Temperature, formulation, amount, timing and actual exposure records", "role": "Required", "role_reason": "This condition connects Temperature, formulation, amount, timing and actual exposure records with the selected heat-illness-prevention question, unmeasured events, original ice slurry/cold water, within-person crossover, people/conditions, environment, time, temperature, denominators and harms.", "application_exception": "Preserve original numbers while distinguishing unmeasured prevention events and grade ? from acute running time and temperature. Distinguish single pre-exercise ice slurry/cold water, people/two conditions, different exhaustion times, pre-exercise/terminal times and laboratory/field settings. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or ingestion, product, exercise, cooling, prevention or treatment instructions are created.", "criterion": "Material for Temperature, formulation, amount, timing and actual exposure records must be linked to the selected subclaim, parent performance context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Ingredients, actual ingestion-time/amount distributions, adherence and correspondence with other products are unverified. This records needed materials; no new research was executed." }, { "item_id": "N05", "question_type": "Evidence condition", "question": "What does the cold-water comparison represent?", "needed": "Control temperature, amount, ingestion and contact records", "role": "Required", "role_reason": "This condition connects Control temperature, amount, ingestion and contact records with the selected heat-illness-prevention question, unmeasured events, original ice slurry/cold water, within-person crossover, people/conditions, environment, time, temperature, denominators and harms.", "application_exception": "Preserve original numbers while distinguishing unmeasured prevention events and grade ? from acute running time and temperature. Distinguish single pre-exercise ice slurry/cold water, people/two conditions, different exhaustion times, pre-exercise/terminal times and laboratory/field settings. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or ingestion, product, exercise, cooling, prevention or treatment instructions are created.", "criterion": "Material for Control temperature, amount, ingestion and contact records must be linked to the selected subclaim, parent performance context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Actual control adherence, concurrent hydration/heat exposure and expectation differences are unverified. This records needed materials; no new research was executed." }, { "item_id": "N06", "question_type": "Evidence condition", "question": "What were the heat and exercise conditions?", "needed": "Temperature, humidity, exposure and exercise records", "role": "Required", "role_reason": "This condition connects Temperature, humidity, exposure and exercise records with the selected heat-illness-prevention question, unmeasured events, original ice slurry/cold water, within-person crossover, people/conditions, environment, time, temperature, denominators and harms.", "application_exception": "Preserve original numbers while distinguishing unmeasured prevention events and grade ? from acute running time and temperature. Distinguish single pre-exercise ice slurry/cold water, people/two conditions, different exhaustion times, pre-exercise/terminal times and laboratory/field settings. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or ingestion, product, exercise, cooling, prevention or treatment instructions are created.", "criterion": "Material for Temperature, humidity, exposure and exercise records must be linked to the selected subclaim, parent performance context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Actual environmental variation, airflow, acclimation, individual workload and heat-exposure correspondence are unverified. This records needed materials; no new research was executed." }, { "item_id": "N07", "question_type": "Evidence condition", "question": "Is time to exhaustion the same as a clinical event?", "needed": "Functional tests and exhaustion definitions versus clinical outcomes", "role": "Required", "role_reason": "This condition connects Functional tests and exhaustion definitions versus clinical outcomes with the selected heat-illness-prevention question, unmeasured events, original ice slurry/cold water, within-person crossover, people/conditions, environment, time, temperature, denominators and harms.", "application_exception": "Preserve original numbers while distinguishing unmeasured prevention events and grade ? from acute running time and temperature. Distinguish single pre-exercise ice slurry/cold water, people/two conditions, different exhaustion times, pre-exercise/terminal times and laboratory/field settings. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or ingestion, product, exercise, cooling, prevention or treatment instructions are created.", "criterion": "Material for Functional tests and exhaustion definitions versus clinical outcomes must be linked to the selected subclaim, parent performance context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Exhaustion assessment, stopping criteria and correspondence with clinical events are unverified. This records needed materials; no new research was executed." }, { "item_id": "N08", "question_type": "Evidence condition", "question": "What are the original performance values and within-person signal?", "needed": "Condition-specific functional results, units, denominators and comparison", "role": "Required", "role_reason": "This condition connects Condition-specific functional results, units, denominators and comparison with the selected heat-illness-prevention question, unmeasured events, original ice slurry/cold water, within-person crossover, people/conditions, environment, time, temperature, denominators and harms.", "application_exception": "Preserve original numbers while distinguishing unmeasured prevention events and grade ? from acute running time and temperature. Distinguish single pre-exercise ice slurry/cold water, people/two conditions, different exhaustion times, pre-exercise/terminal times and laboratory/field settings. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or ingestion, product, exercise, cooling, prevention or treatment instructions are created.", "criterion": "Material for Condition-specific functional results, units, denominators and comparison must be linked to the selected subclaim, parent performance context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: The statistical definition of ±, analysis denominators/model, exact functional-effect CI and prevention effects are unverified. This records needed materials; no new research was executed." }, { "item_id": "N09", "question_type": "Evidence condition", "question": "At what time was pre-exercise temperature measured?", "needed": "Pre-exercise measurement, units, comparison and methods", "role": "Required", "role_reason": "This condition connects Pre-exercise measurement, units, comparison and methods with the selected heat-illness-prevention question, unmeasured events, original ice slurry/cold water, within-person crossover, people/conditions, environment, time, temperature, denominators and harms.", "application_exception": "Preserve original numbers while distinguishing unmeasured prevention events and grade ? from acute running time and temperature. Distinguish single pre-exercise ice slurry/cold water, people/two conditions, different exhaustion times, pre-exercise/terminal times and laboratory/field settings. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or ingestion, product, exercise, cooling, prevention or treatment instructions are created.", "criterion": "Material for Pre-exercise measurement, units, comparison and methods must be linked to the selected subclaim, parent performance context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Exact pre-exercise timing, original condition values, denominators, measurement methods and CIs are unverified. This records needed materials; no new research was executed." }, { "item_id": "N10", "question_type": "Evidence condition", "question": "How did temperature at exhaustion differ?", "needed": "End times, original condition values and comparison scope", "role": "Required", "role_reason": "This condition connects End times, original condition values and comparison scope with the selected heat-illness-prevention question, unmeasured events, original ice slurry/cold water, within-person crossover, people/conditions, environment, time, temperature, denominators and harms.", "application_exception": "Preserve original numbers while distinguishing unmeasured prevention events and grade ? from acute running time and temperature. Distinguish single pre-exercise ice slurry/cold water, people/two conditions, different exhaustion times, pre-exercise/terminal times and laboratory/field settings. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or ingestion, product, exercise, cooling, prevention or treatment instructions are created.", "criterion": "Material for End times, original condition values and comparison scope must be linked to the selected subclaim, parent performance context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Measurement times, denominators, exact CIs and correspondence with clinical heat-illness confirmation are unverified. This records needed materials; no new research was executed." }, { "item_id": "N11", "question_type": "Evidence condition", "question": "Are temperature at each exhaustion time and at the same exercise time the same comparison?", "needed": "Temperature at matched exercise times and each condition's end time", "role": "Required", "role_reason": "This condition connects Temperature at matched exercise times and each condition's end time with the selected heat-illness-prevention question, unmeasured events, original ice slurry/cold water, within-person crossover, people/conditions, environment, time, temperature, denominators and harms.", "application_exception": "Preserve original numbers while distinguishing unmeasured prevention events and grade ? from acute running time and temperature. Distinguish single pre-exercise ice slurry/cold water, people/two conditions, different exhaustion times, pre-exercise/terminal times and laboratory/field settings. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or ingestion, product, exercise, cooling, prevention or treatment instructions are created.", "criterion": "Material for Temperature at matched exercise times and each condition's end time must be linked to the selected subclaim, parent performance context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Temperature trajectories at the same time/workload, end-time correspondence and exposure/event relationships are unverified. This records needed materials; no new research was executed." }, { "item_id": "N12", "question_type": "Evidence condition", "question": "How much of randomization, counterbalancing and crossover was confirmed?", "needed": "Sequence generation, washout, periods and carryover", "role": "Required", "role_reason": "This condition connects Sequence generation, washout, periods and carryover with the selected heat-illness-prevention question, unmeasured events, original ice slurry/cold water, within-person crossover, people/conditions, environment, time, temperature, denominators and harms.", "application_exception": "Preserve original numbers while distinguishing unmeasured prevention events and grade ? from acute running time and temperature. Distinguish single pre-exercise ice slurry/cold water, people/two conditions, different exhaustion times, pre-exercise/terminal times and laboratory/field settings. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or ingestion, product, exercise, cooling, prevention or treatment instructions are created.", "criterion": "Material for Sequence generation, washout, periods and carryover must be linked to the selected subclaim, parent performance context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Sequence generation/concealment, between-condition intervals, carryover and within-person analysis models are unverified. This records needed materials; no new research was executed." }, { "item_id": "N13", "question_type": "Evidence condition", "question": "Were masking, exhaustion assessment and expectations confirmed?", "needed": "Participant/assessor masking and stopping assessment", "role": "Required", "role_reason": "This condition connects Participant/assessor masking and stopping assessment with the selected heat-illness-prevention question, unmeasured events, original ice slurry/cold water, within-person crossover, people/conditions, environment, time, temperature, denominators and harms.", "application_exception": "Preserve original numbers while distinguishing unmeasured prevention events and grade ? from acute running time and temperature. Distinguish single pre-exercise ice slurry/cold water, people/two conditions, different exhaustion times, pre-exercise/terminal times and laboratory/field settings. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or ingestion, product, exercise, cooling, prevention or treatment instructions are created.", "criterion": "Material for Participant/assessor masking and stopping assessment must be linked to the selected subclaim, parent performance context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Masking, expectation differences, stopping assessment and analyst awareness of conditions are unverified. This records needed materials; no new research was executed." }, { "item_id": "N14", "question_type": "Evidence condition", "question": "Were condition completion, missingness and analysis populations confirmed?", "needed": "Analyses and missingness by person, condition and endpoint", "role": "Required", "role_reason": "This condition connects Analyses and missingness by person, condition and endpoint with the selected heat-illness-prevention question, unmeasured events, original ice slurry/cold water, within-person crossover, people/conditions, environment, time, temperature, denominators and harms.", "application_exception": "Preserve original numbers while distinguishing unmeasured prevention events and grade ? from acute running time and temperature. Distinguish single pre-exercise ice slurry/cold water, people/two conditions, different exhaustion times, pre-exercise/terminal times and laboratory/field settings. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or ingestion, product, exercise, cooling, prevention or treatment instructions are created.", "criterion": "Material for Analyses and missingness by person, condition and endpoint must be linked to the selected subclaim, parent performance context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Completion by condition, missing endpoints, exclusions, analysis populations and missing-data handling are unverified. This records needed materials; no new research was executed." }, { "item_id": "N15", "question_type": "Evidence condition", "question": "Are event data available to establish prevention effects and precision?", "needed": "Clinical prevention estimates, event analyses and CIs", "role": "Required", "role_reason": "This condition connects Clinical prevention estimates, event analyses and CIs with the selected heat-illness-prevention question, unmeasured events, original ice slurry/cold water, within-person crossover, people/conditions, environment, time, temperature, denominators and harms.", "application_exception": "Preserve original numbers while distinguishing unmeasured prevention events and grade ? from acute running time and temperature. Distinguish single pre-exercise ice slurry/cold water, people/two conditions, different exhaustion times, pre-exercise/terminal times and laboratory/field settings. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or ingestion, product, exercise, cooling, prevention or treatment instructions are created.", "criterion": "Material for Clinical prevention estimates, event analyses and CIs must be linked to the selected subclaim, parent performance context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Clinical prevention estimates, event counts, denominators, CIs and relevance criteria are unverified. This records needed materials; no new research was executed." }, { "item_id": "N16", "question_type": "Evidence condition", "question": "Were registration, protocol and prespecified hierarchy read?", "needed": "Trial registration, plans, outcome hierarchy and changes", "role": "Required", "role_reason": "This condition connects Trial registration, plans, outcome hierarchy and changes with the selected heat-illness-prevention question, unmeasured events, original ice slurry/cold water, within-person crossover, people/conditions, environment, time, temperature, denominators and harms.", "application_exception": "Preserve original numbers while distinguishing unmeasured prevention events and grade ? from acute running time and temperature. Distinguish single pre-exercise ice slurry/cold water, people/two conditions, different exhaustion times, pre-exercise/terminal times and laboratory/field settings. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or ingestion, product, exercise, cooling, prevention or treatment instructions are created.", "criterion": "Material for Trial registration, plans, outcome hierarchy and changes must be linked to the selected subclaim, parent performance context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Registration existence, prespecified endpoints, protocol, SAP and change history are unverified. This records needed materials; no new research was executed." }, { "item_id": "N17", "question_type": "Evidence condition", "question": "Were concurrent hydration, environment and activity controlled?", "needed": "Other exposures, shared management and adherence", "role": "Required", "role_reason": "This condition connects Other exposures, shared management and adherence with the selected heat-illness-prevention question, unmeasured events, original ice slurry/cold water, within-person crossover, people/conditions, environment, time, temperature, denominators and harms.", "application_exception": "Preserve original numbers while distinguishing unmeasured prevention events and grade ? from acute running time and temperature. Distinguish single pre-exercise ice slurry/cold water, people/two conditions, different exhaustion times, pre-exercise/terminal times and laboratory/field settings. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or ingestion, product, exercise, cooling, prevention or treatment instructions are created.", "criterion": "Material for Other exposures, shared management and adherence must be linked to the selected subclaim, parent performance context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Detailed concurrent exposures/management before and during the experiment, workload adjustment and adherence are unverified. This records needed materials; no new research was executed." }, { "item_id": "N18", "question_type": "Evidence condition", "question": "Are ingestion during exercise and repeated use the same question?", "needed": "Direct data for exposures other than a single pre-exercise dose", "role": "Required", "role_reason": "This condition connects Direct data for exposures other than a single pre-exercise dose with the selected heat-illness-prevention question, unmeasured events, original ice slurry/cold water, within-person crossover, people/conditions, environment, time, temperature, denominators and harms.", "application_exception": "Preserve original numbers while distinguishing unmeasured prevention events and grade ? from acute running time and temperature. Distinguish single pre-exercise ice slurry/cold water, people/two conditions, different exhaustion times, pre-exercise/terminal times and laboratory/field settings. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or ingestion, product, exercise, cooling, prevention or treatment instructions are created.", "criterion": "Material for Direct data for exposures other than a single pre-exercise dose must be linked to the selected subclaim, parent performance context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Functional, heat-illness and safety data for other times and repeated exposure are unverified. This records needed materials; no new research was executed." }, { "item_id": "N19", "question_type": "Evidence condition", "question": "Does laboratory function answer real race or other-sport questions?", "needed": "Direct field and sport-specific results", "role": "Required", "role_reason": "This condition connects Direct field and sport-specific results with the selected heat-illness-prevention question, unmeasured events, original ice slurry/cold water, within-person crossover, people/conditions, environment, time, temperature, denominators and harms.", "application_exception": "Preserve original numbers while distinguishing unmeasured prevention events and grade ? from acute running time and temperature. Distinguish single pre-exercise ice slurry/cold water, people/two conditions, different exhaustion times, pre-exercise/terminal times and laboratory/field settings. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or ingestion, product, exercise, cooling, prevention or treatment instructions are created.", "criterion": "Material for Direct field and sport-specific results must be linked to the selected subclaim, parent performance context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Clinical prevention results in actual races, other sports and field settings are unverified. This records needed materials; no new research was executed." }, { "item_id": "N20", "question_type": "Evidence condition", "question": "Are there data for generalization to other populations?", "needed": "Direct data by age, sex, disease and heat acclimation", "role": "Required", "role_reason": "This condition connects Direct data by age, sex, disease and heat acclimation with the selected heat-illness-prevention question, unmeasured events, original ice slurry/cold water, within-person crossover, people/conditions, environment, time, temperature, denominators and harms.", "application_exception": "Preserve original numbers while distinguishing unmeasured prevention events and grade ? from acute running time and temperature. Distinguish single pre-exercise ice slurry/cold water, people/two conditions, different exhaustion times, pre-exercise/terminal times and laboratory/field settings. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or ingestion, product, exercise, cooling, prevention or treatment instructions are created.", "criterion": "Material for Direct data by age, sex, disease and heat acclimation must be linked to the selected subclaim, parent performance context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Eligibility, exposure, clinical-event and safety data in other populations are unverified. This records needed materials; no new research was executed." }, { "item_id": "N21", "question_type": "Evidence condition", "question": "What is the scope of the original support/commercial-involvement statement?", "needed": "Original funding, product support, employee authors and COI disclosures", "role": "Required", "role_reason": "This condition connects Original funding, product support, employee authors and COI disclosures with the selected heat-illness-prevention question, unmeasured events, original ice slurry/cold water, within-person crossover, people/conditions, environment, time, temperature, denominators and harms.", "application_exception": "Preserve original numbers while distinguishing unmeasured prevention events and grade ? from acute running time and temperature. Distinguish single pre-exercise ice slurry/cold water, people/two conditions, different exhaustion times, pre-exercise/terminal times and laboratory/field settings. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or ingestion, product, exercise, cooling, prevention or treatment instructions are created.", "criterion": "Material for Original funding, product support, employee authors and COI disclosures must be linked to the selected subclaim, parent performance context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Funding roles, products/free support, employee authors and detailed COI information are unverified. This records needed materials; no new research was executed." }, { "item_id": "N22", "question_type": "Evidence condition", "question": "Were gastrointestinal discomfort and adverse events actually collected?", "needed": "Actual event collection, exposure, denominators and discontinuation", "role": "Supplementary", "role_reason": "This condition connects Actual event collection, exposure, denominators and discontinuation with the selected heat-illness-prevention question, unmeasured events, original ice slurry/cold water, within-person crossover, people/conditions, environment, time, temperature, denominators and harms.", "application_exception": "Preserve original numbers while distinguishing unmeasured prevention events and grade ? from acute running time and temperature. Distinguish single pre-exercise ice slurry/cold water, people/two conditions, different exhaustion times, pre-exercise/terminal times and laboratory/field settings. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or ingestion, product, exercise, cooling, prevention or treatment instructions are created.", "criterion": "Material for Actual event collection, exposure, denominators and discontinuation must be linked to the selected subclaim, parent performance context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Systematic adverse-event definitions, collection, denominators, discontinuation and harms in long-term/vulnerable populations are unverified. This records needed materials; no new research was executed." }, { "item_id": "N23", "question_type": "Evidence condition", "question": "Are the same crossover trial and independent replication distinguished?", "needed": "Relationships among reports, people, conditions and study families", "role": "Required", "role_reason": "This condition connects Relationships among reports, people, conditions and study families with the selected heat-illness-prevention question, unmeasured events, original ice slurry/cold water, within-person crossover, people/conditions, environment, time, temperature, denominators and harms.", "application_exception": "Preserve original numbers while distinguishing unmeasured prevention events and grade ? from acute running time and temperature. Distinguish single pre-exercise ice slurry/cold water, people/two conditions, different exhaustion times, pre-exercise/terminal times and laboratory/field settings. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or ingestion, product, exercise, cooling, prevention or treatment instructions are created.", "criterion": "Material for Relationships among reports, people, conditions and study families must be linked to the selected subclaim, parent performance context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Separate direct trials matching the same prevention/exposure question and study-family independence are unverified. This records needed materials; no new research was executed." }, { "item_id": "N24", "question_type": "Evidence condition", "question": "Does a single experiment answer long-term clinical questions?", "needed": "Acute function/temperature versus long-term events", "role": "Required", "role_reason": "This condition connects Acute function/temperature versus long-term events with the selected heat-illness-prevention question, unmeasured events, original ice slurry/cold water, within-person crossover, people/conditions, environment, time, temperature, denominators and harms.", "application_exception": "Preserve original numbers while distinguishing unmeasured prevention events and grade ? from acute running time and temperature. Distinguish single pre-exercise ice slurry/cold water, people/two conditions, different exhaustion times, pre-exercise/terminal times and laboratory/field settings. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or ingestion, product, exercise, cooling, prevention or treatment instructions are created.", "criterion": "Material for Acute function/temperature versus long-term events must be linked to the selected subclaim, parent performance context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Long-term/repeated clinical prevention, safety and persistent-effect data are unverified. This records needed materials; no new research was executed." }, { "item_id": "N25", "question_type": "Evidence condition", "question": "Were original values, axes, bilingual text, dates and history preserved?", "needed": "Original parent C54, subclaim ?, axes and correction records", "role": "Required", "role_reason": "This condition connects Original parent C54, subclaim ?, axes and correction records with the selected heat-illness-prevention question, unmeasured events, original ice slurry/cold water, within-person crossover, people/conditions, environment, time, temperature, denominators and harms.", "application_exception": "Preserve original numbers while distinguishing unmeasured prevention events and grade ? from acute running time and temperature. Distinguish single pre-exercise ice slurry/cold water, people/two conditions, different exhaustion times, pre-exercise/terminal times and laboratory/field settings. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or ingestion, product, exercise, cooling, prevention or treatment instructions are created.", "criterion": "Material for Original parent C54, subclaim ?, axes and correction records must be linked to the selected subclaim, parent performance context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: The subclaim's score/status/axes, new corrections and external comparison of detailed historical checks are unverified. This records needed materials; no new research was executed." }, { "item_id": "N26", "question_type": "Evidence condition", "question": "What was actually read and what can be updated?", "needed": "Stored summary versus unread external materials and update records", "role": "Required", "role_reason": "This condition connects Stored summary versus unread external materials and update records with the selected heat-illness-prevention question, unmeasured events, original ice slurry/cold water, within-person crossover, people/conditions, environment, time, temperature, denominators and harms.", "application_exception": "Preserve original numbers while distinguishing unmeasured prevention events and grade ? from acute running time and temperature. Distinguish single pre-exercise ice slurry/cold water, people/two conditions, different exhaustion times, pre-exercise/terminal times and laboratory/field settings. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or ingestion, product, exercise, cooling, prevention or treatment instructions are created.", "criterion": "Material for Stored summary versus unread external materials and update records must be linked to the selected subclaim, parent performance context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: External original acquisition, actual reading and review of existing content remain incomplete. Additional-material identities, before/after values, condition revisions and verdict changes must be separate events. This records needed materials; no new research was executed." } ] }