{ "schema_version": "chamgap-public-criteria-1.0", "title": "Ice-slurry precooling × running time to exhaustion in heat", "language": "en", "translation_date": "2026-10-16", "criteria_version": "1.0", "criteria_date": "2026-10-06", "condition_origin": "Chamgap's own application conditions", "method_sources": [ { "id": "M03", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03", "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13", "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.", "review_level": "Methodological principles stated in existing pilot materials and condition templates were referenced. The methodological text was not reviewed again in this work." }, { "id": "M04", "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04", "section": "§4.5, §4.6.1–4.6.3, MECIR C42", "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.", "review_level": "Methodological principles stated in existing pilot materials and condition templates were referenced. The methodological text was not reviewed again in this work." }, { "id": "M08", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08", "section": "§8.1–8.2.3, Table 8.2.a", "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.", "review_level": "Methodological principles stated in existing pilot materials and condition templates were referenced. The methodological text was not reviewed again in this work." }, { "id": "M15", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15", "section": "§15.2.4, §15.3.1–15.3.3", "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.", "review_level": "Methodological principles stated in existing pilot materials and condition templates were referenced. The methodological text was not reviewed again in this work." }, { "id": "M19", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19", "section": "§19.1.2, §19.2.1–19.2.4", "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.", "review_level": "Methodological principles stated in existing pilot materials and condition templates were referenced. The methodological text was not reviewed again in this work." } ], "status_dictionary": { "Met": "The original content has been reviewed as meeting the conditions. This status is not used in this preparation.", "Partly verified": "Some information in the stored summary was linked during preparation; clinical verification or review is not complete.", "Unverified": "Required direct values, definitions or materials have not been established within the current storage and reading scope. This does not mean zero effect, no papers or failed access.", "Review incomplete": "Awaiting user review, or actual review remains incomplete.", "Not reported": "Used only when original materials were actually read and the outcome was judged unreported. Not used for external materials unread in this work.", "Inaccessible": "Used only when an actual access attempt has a recorded failure. Not used for access that was not attempted in this work.", "Insufficient evidence for the conditions": "Indicates insufficient direct materials for the relevant scope or conditions; it is not a new grade.", "Not applicable": "Used when the reason it does not apply to the original question is stated.", "Conflicting data": "Retains the scope of conflicting statements in original materials; it is not an arbitrary reassessment." }, "requirements": [ { "item_id": "N01", "question_type": "Evidence condition", "question": "What are the selected running-time question and verdict?", "needed": "Selected subclaim versus parent and heat-illness-prevention questions", "role": "Required", "role_reason": "This condition connects Selected subclaim versus parent and heat-illness-prevention questions with selected running time to exhaustion, study population, original ice slurry/cold water, within-person crossover, environment, times, denominators, temperature and harms.", "application_exception": "Preserve original numbers while distinguishing single pre-exercise ice slurry/cold water comparisons, people/crossover conditions, time/temperature, pre-exercise/terminal times, exhaustion tests and real race/heat-illness events. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or preparation, ingestion, cooling, exercise, prevention or treatment instructions are created.", "criterion": "Material for Selected subclaim versus parent and heat-illness-prevention questions must be linked to the selected subclaim, parent context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Clinical independence of the question was not newly certified. This records needed materials; no new research was executed." }, { "item_id": "N02", "question_type": "Evidence condition", "question": "What are the original subclaim grade, note and absent values?", "needed": "Subclaim grade/note and absent score/status/axes", "role": "Required", "role_reason": "This condition connects Subclaim grade/note versus absent score, status and axes with selected running time to exhaustion, study population, original ice slurry/cold water, within-person crossover, environment, times, denominators, temperature and harms.", "application_exception": "Preserve original numbers while distinguishing single pre-exercise ice slurry/cold water comparisons, people/crossover conditions, time/temperature, pre-exercise/terminal times, exhaustion tests and real race/heat-illness events. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or preparation, ingestion, cooling, exercise, prevention or treatment instructions are created.", "criterion": "Material for Subclaim grade/note versus absent score, status and axes must be linked to the selected subclaim, parent context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: The selected subclaim's own score, status and axes are unrecorded. This records needed materials; no new research was executed." }, { "item_id": "N03", "question_type": "Evidence condition", "question": "In which participants was the result observed?", "needed": "Healthy men, recruitment and population scope", "role": "Required", "role_reason": "This condition connects Healthy men, recruitment and population scope with selected running time to exhaustion, study population, original ice slurry/cold water, within-person crossover, environment, times, denominators, temperature and harms.", "application_exception": "Preserve original numbers while distinguishing single pre-exercise ice slurry/cold water comparisons, people/crossover conditions, time/temperature, pre-exercise/terminal times, exhaustion tests and real race/heat-illness events. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or preparation, ingestion, cooling, exercise, prevention or treatment instructions are created.", "criterion": "Material for Healthy men, recruitment and population scope must be linked to the selected subclaim, parent context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Exact age, training level, recruitment/eligibility criteria and baseline health data are unverified. This records needed materials; no new research was executed." }, { "item_id": "N04", "question_type": "Evidence condition", "question": "How are formulation, temperature and study exposure distinguished?", "needed": "Original formulation, route and single pre-exercise ice-slurry exposure", "role": "Required", "role_reason": "This condition connects Original formulation, route and single pre-exercise ice-slurry exposure with selected running time to exhaustion, study population, original ice slurry/cold water, within-person crossover, environment, times, denominators, temperature and harms.", "application_exception": "Preserve original numbers while distinguishing single pre-exercise ice slurry/cold water comparisons, people/crossover conditions, time/temperature, pre-exercise/terminal times, exhaustion tests and real race/heat-illness events. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or preparation, ingestion, cooling, exercise, prevention or treatment instructions are created.", "criterion": "Material for Original formulation, route and single pre-exercise ice-slurry exposure must be linked to the selected subclaim, parent context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Composition, ice fraction, preparation/quality, exact ingestion intervals and actual adherence data are unverified. This records needed materials; no new research was executed." }, { "item_id": "N05", "question_type": "Evidence condition", "question": "What was the control condition and what does the comparison answer?", "needed": "Cold-water temperature/exposure and the contrasted conditions", "role": "Required", "role_reason": "This condition connects Cold-water temperature/exposure and the contrasted conditions with selected running time to exhaustion, study population, original ice slurry/cold water, within-person crossover, environment, times, denominators, temperature and harms.", "application_exception": "Preserve original numbers while distinguishing single pre-exercise ice slurry/cold water comparisons, people/crossover conditions, time/temperature, pre-exercise/terminal times, exhaustion tests and real race/heat-illness events. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or preparation, ingestion, cooling, exercise, prevention or treatment instructions are created.", "criterion": "Material for Cold-water temperature/exposure and the contrasted conditions must be linked to the selected subclaim, parent context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Cold-water composition, ingestion procedures and adherence by condition are unverified. This records needed materials; no new research was executed." }, { "item_id": "N06", "question_type": "Evidence condition", "question": "What were the actual heat and humidity conditions?", "needed": "Experimental temperature, relative humidity and extrapolation", "role": "Required", "role_reason": "This condition connects Experimental temperature, relative humidity and extrapolation with selected running time to exhaustion, study population, original ice slurry/cold water, within-person crossover, environment, times, denominators, temperature and harms.", "application_exception": "Preserve original numbers while distinguishing single pre-exercise ice slurry/cold water comparisons, people/crossover conditions, time/temperature, pre-exercise/terminal times, exhaustion tests and real race/heat-illness events. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or preparation, ingestion, cooling, exercise, prevention or treatment instructions are created.", "criterion": "Material for Experimental temperature, relative humidity and extrapolation must be linked to the selected subclaim, parent context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Environmental maintenance/measurement procedures, airflow, sunlight and effects in other conditions are unverified. This records needed materials; no new research was executed." }, { "item_id": "N07", "question_type": "Evidence condition", "question": "What were the exercise intensity and exhaustion-test procedures?", "needed": "Running at first ventilatory threshold and exhaustion assessment", "role": "Required", "role_reason": "This condition connects Running at first ventilatory threshold and exhaustion assessment with selected running time to exhaustion, study population, original ice slurry/cold water, within-person crossover, environment, times, denominators, temperature and harms.", "application_exception": "Preserve original numbers while distinguishing single pre-exercise ice slurry/cold water comparisons, people/crossover conditions, time/temperature, pre-exercise/terminal times, exhaustion tests and real race/heat-illness events. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or preparation, ingestion, cooling, exercise, prevention or treatment instructions are created.", "criterion": "Material for Running at first ventilatory threshold and exhaustion assessment must be linked to the selected subclaim, parent context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Ventilatory-threshold determination, running equipment/speed maintenance, stopping criteria and assessor procedures are unverified. This records needed materials; no new research was executed." }, { "item_id": "N08", "question_type": "Evidence condition", "question": "What time frame does time to exhaustion represent?", "needed": "Time in minutes and test start/end definitions", "role": "Required", "role_reason": "This condition connects Time in minutes and test start/end definitions with selected running time to exhaustion, study population, original ice slurry/cold water, within-person crossover, environment, times, denominators, temperature and harms.", "application_exception": "Preserve original numbers while distinguishing single pre-exercise ice slurry/cold water comparisons, people/crossover conditions, time/temperature, pre-exercise/terminal times, exhaustion tests and real race/heat-illness events. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or preparation, ingestion, cooling, exercise, prevention or treatment instructions are created.", "criterion": "Material for Time in minutes and test start/end definitions must be linked to the selected subclaim, parent context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Exact start/end definitions and the prespecified outcome hierarchy are unverified. This records needed materials; no new research was executed." }, { "item_id": "N09", "question_type": "Evidence condition", "question": "How are the original time values for the two conditions preserved?", "needed": "Original condition means, ± notation and P value", "role": "Required", "role_reason": "This condition connects Original condition means, ± notation and P value with selected running time to exhaustion, study population, original ice slurry/cold water, within-person crossover, environment, times, denominators, temperature and harms.", "application_exception": "Preserve original numbers while distinguishing single pre-exercise ice slurry/cold water comparisons, people/crossover conditions, time/temperature, pre-exercise/terminal times, exhaustion tests and real race/heat-illness events. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or preparation, ingestion, cooling, exercise, prevention or treatment instructions are created.", "criterion": "Material for Original condition means, ± notation and P value must be linked to the selected subclaim, parent context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: The meaning of ±, such as SD or SE, the within-person analysis model and effect CI are unverified. This records needed materials; no new research was executed." }, { "item_id": "N10", "question_type": "Evidence condition", "question": "What relative-increase wording was originally reported?", "needed": "+19±6% and the reader summary's 19%", "role": "Required", "role_reason": "This condition connects +19±6% and the reader summary's 19% with selected running time to exhaustion, study population, original ice slurry/cold water, within-person crossover, environment, times, denominators, temperature and harms.", "application_exception": "Preserve original numbers while distinguishing single pre-exercise ice slurry/cold water comparisons, people/crossover conditions, time/temperature, pre-exercise/terminal times, exhaustion tests and real race/heat-illness events. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or preparation, ingestion, cooling, exercise, prevention or treatment instructions are created.", "criterion": "Material for +19±6% and the reader summary's 19% must be linked to the selected subclaim, parent context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: The percentage formula, individual calculation method, definition of ± and corresponding CI are unverified. This records needed materials; no new research was executed." }, { "item_id": "N11", "question_type": "Evidence condition", "question": "What does the statement that everyone improved in the same direction mean?", "needed": "Within-person directional consistency and individual data", "role": "Required", "role_reason": "This condition connects Within-person directional consistency and individual data with selected running time to exhaustion, study population, original ice slurry/cold water, within-person crossover, environment, times, denominators, temperature and harms.", "application_exception": "Preserve original numbers while distinguishing single pre-exercise ice slurry/cold water comparisons, people/crossover conditions, time/temperature, pre-exercise/terminal times, exhaustion tests and real race/heat-illness events. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or preparation, ingestion, cooling, exercise, prevention or treatment instructions are created.", "criterion": "Material for Within-person directional consistency and individual data must be linked to the selected subclaim, parent context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Individual times, relative changes, errors and observations by order are unverified. This records needed materials; no new research was executed." }, { "item_id": "N12", "question_type": "Evidence condition", "question": "Have the within-person difference and precision been confirmed?", "needed": "Paired effect of interest, CI and meaning of ±", "role": "Required", "role_reason": "This condition connects Paired effect of interest, CI and meaning of ± with selected running time to exhaustion, study population, original ice slurry/cold water, within-person crossover, environment, times, denominators, temperature and harms.", "application_exception": "Preserve original numbers while distinguishing single pre-exercise ice slurry/cold water comparisons, people/crossover conditions, time/temperature, pre-exercise/terminal times, exhaustion tests and real race/heat-illness events. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or preparation, ingestion, cooling, exercise, prevention or treatment instructions are created.", "criterion": "Material for Paired effect of interest, CI and meaning of ± must be linked to the selected subclaim, parent context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: The paired-difference variance, correlation, CI and clinical-importance criterion are unverified. This records needed materials; no new research was executed." }, { "item_id": "N13", "question_type": "Evidence condition", "question": "How is pre-exercise rectal temperature distinguished from the time result?", "needed": "Pre-exercise rectal temperature and measurement time", "role": "Supplementary", "role_reason": "This condition connects Pre-exercise rectal temperature and measurement time with selected running time to exhaustion, study population, original ice slurry/cold water, within-person crossover, environment, times, denominators, temperature and harms.", "application_exception": "Preserve original numbers while distinguishing single pre-exercise ice slurry/cold water comparisons, people/crossover conditions, time/temperature, pre-exercise/terminal times, exhaustion tests and real race/heat-illness events. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or preparation, ingestion, cooling, exercise, prevention or treatment instructions are created.", "criterion": "Material for Pre-exercise rectal temperature and measurement time must be linked to the selected subclaim, parent context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Baseline time, absolute values, CI and temperature measurement methods are unverified. This records needed materials; no new research was executed." }, { "item_id": "N14", "question_type": "Evidence condition", "question": "What was the original temperature result at exhaustion?", "needed": "Terminal rectal temperature, original comparison and P value", "role": "Supplementary", "role_reason": "This condition connects Terminal rectal temperature, original comparison and P value with selected running time to exhaustion, study population, original ice slurry/cold water, within-person crossover, environment, times, denominators, temperature and harms.", "application_exception": "Preserve original numbers while distinguishing single pre-exercise ice slurry/cold water comparisons, people/crossover conditions, time/temperature, pre-exercise/terminal times, exhaustion tests and real race/heat-illness events. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or preparation, ingestion, cooling, exercise, prevention or treatment instructions are created.", "criterion": "Material for Terminal rectal temperature, original comparison and P value must be linked to the selected subclaim, parent context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Measurement error, variance, CI and comparison at the same exercise time are unverified. This records needed materials; no new research was executed." }, { "item_id": "N15", "question_type": "Evidence condition", "question": "Why is heat-illness prevention separate context?", "needed": "Prevention grade ?, note and actual event measurement", "role": "Supplementary", "role_reason": "This condition connects Prevention grade ?, note and actual event measurement with selected running time to exhaustion, study population, original ice slurry/cold water, within-person crossover, environment, times, denominators, temperature and harms.", "application_exception": "Preserve original numbers while distinguishing single pre-exercise ice slurry/cold water comparisons, people/crossover conditions, time/temperature, pre-exercise/terminal times, exhaustion tests and real race/heat-illness events. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or preparation, ingestion, cooling, exercise, prevention or treatment instructions are created.", "criterion": "Material for Prevention grade ?, note and actual event measurement must be linked to the selected subclaim, parent context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Direct heat-illness definitions, events, denominators and follow-up are unverified. This records needed materials; no new research was executed." }, { "item_id": "N16", "question_type": "Evidence condition", "question": "Were real race performance and other sports directly tested?", "needed": "Exhaustion tests versus race results", "role": "Supplementary", "role_reason": "This condition connects Exhaustion tests versus race results with selected running time to exhaustion, study population, original ice slurry/cold water, within-person crossover, environment, times, denominators, temperature and harms.", "application_exception": "Preserve original numbers while distinguishing single pre-exercise ice slurry/cold water comparisons, people/crossover conditions, time/temperature, pre-exercise/terminal times, exhaustion tests and real race/heat-illness events. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or preparation, ingestion, cooling, exercise, prevention or treatment instructions are created.", "criterion": "Material for Exhaustion tests versus race results must be linked to the selected subclaim, parent context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Direct effects and CIs for fixed-distance/fixed-time races and individual sports are unverified. This records needed materials; no new research was executed." }, { "item_id": "N17", "question_type": "Evidence condition", "question": "How are repeated use and during-exercise ingestion distinguished?", "needed": "Single pre-exercise exposure versus repeated strategies", "role": "Supplementary", "role_reason": "This condition connects Single pre-exercise exposure versus repeated strategies with selected running time to exhaustion, study population, original ice slurry/cold water, within-person crossover, environment, times, denominators, temperature and harms.", "application_exception": "Preserve original numbers while distinguishing single pre-exercise ice slurry/cold water comparisons, people/crossover conditions, time/temperature, pre-exercise/terminal times, exhaustion tests and real race/heat-illness events. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or preparation, ingestion, cooling, exercise, prevention or treatment instructions are created.", "criterion": "Material for Single pre-exercise exposure versus repeated strategies must be linked to the selected subclaim, parent context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Direct data on repeated exposure, long-term effects and safety are unverified. This records needed materials; no new research was executed." }, { "item_id": "N18", "question_type": "Evidence condition", "question": "What was originally recorded about the randomized counterbalanced crossover design?", "needed": "Condition-order allocation and within-person crossover", "role": "Required", "role_reason": "This condition connects Condition-order allocation and within-person crossover with selected running time to exhaustion, study population, original ice slurry/cold water, within-person crossover, environment, times, denominators, temperature and harms.", "application_exception": "Preserve original numbers while distinguishing single pre-exercise ice slurry/cold water comparisons, people/crossover conditions, time/temperature, pre-exercise/terminal times, exhaustion tests and real race/heat-illness events. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or preparation, ingestion, cooling, exercise, prevention or treatment instructions are created.", "criterion": "Material for Condition-order allocation and within-person crossover must be linked to the selected subclaim, parent context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Sequence generation, allocation concealment and participant numbers by condition order are unverified. This records needed materials; no new research was executed." }, { "item_id": "N19", "question_type": "Evidence condition", "question": "Were crossover periods, washout and carryover addressed?", "needed": "Between-condition intervals, period/order effects and analysis", "role": "Required", "role_reason": "This condition connects Between-condition intervals, period/order effects and analysis with selected running time to exhaustion, study population, original ice slurry/cold water, within-person crossover, environment, times, denominators, temperature and harms.", "application_exception": "Preserve original numbers while distinguishing single pre-exercise ice slurry/cold water comparisons, people/crossover conditions, time/temperature, pre-exercise/terminal times, exhaustion tests and real race/heat-illness events. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or preparation, ingestion, cooling, exercise, prevention or treatment instructions are created.", "criterion": "Material for Between-condition intervals, period/order effects and analysis must be linked to the selected subclaim, parent context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Period, order and carryover effects and the applied model are unverified. This records needed materials; no new research was executed." }, { "item_id": "N20", "question_type": "Evidence condition", "question": "What factors could affect masking, motivation and exhaustion measurement?", "needed": "Participant/assessor masking and exhaustion assessment", "role": "Required", "role_reason": "This condition connects Participant/assessor masking and exhaustion assessment with selected running time to exhaustion, study population, original ice slurry/cold water, within-person crossover, environment, times, denominators, temperature and harms.", "application_exception": "Preserve original numbers while distinguishing single pre-exercise ice slurry/cold water comparisons, people/crossover conditions, time/temperature, pre-exercise/terminal times, exhaustion tests and real race/heat-illness events. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or preparation, ingestion, cooling, exercise, prevention or treatment instructions are created.", "criterion": "Material for Participant/assessor masking and exhaustion assessment must be linked to the selected subclaim, parent context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Masking, condition recognition, encouragement and stopping-assessment procedures are unverified. This records needed materials; no new research was executed." }, { "item_id": "N21", "question_type": "Evidence condition", "question": "Were shared hydration, meals, exercise and acclimation controlled?", "needed": "Condition-specific baseline state and concurrent exposure", "role": "Required", "role_reason": "This condition connects Condition-specific baseline state and concurrent exposure with selected running time to exhaustion, study population, original ice slurry/cold water, within-person crossover, environment, times, denominators, temperature and harms.", "application_exception": "Preserve original numbers while distinguishing single pre-exercise ice slurry/cold water comparisons, people/crossover conditions, time/temperature, pre-exercise/terminal times, exhaustion tests and real race/heat-illness events. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or preparation, ingestion, cooling, exercise, prevention or treatment instructions are created.", "criterion": "Material for Condition-specific baseline state and concurrent exposure must be linked to the selected subclaim, parent context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Baseline hydration, nutrition, training and heat-acclimation data by condition are unverified. This records needed materials; no new research was executed." }, { "item_id": "N22", "question_type": "Evidence condition", "question": "What are the participant, period and outcome denominators?", "needed": "Allocation, completion and condition/outcome denominators", "role": "Required", "role_reason": "This condition connects Allocation, completion and condition/outcome denominators with selected running time to exhaustion, study population, original ice slurry/cold water, within-person crossover, environment, times, denominators, temperature and harms.", "application_exception": "Preserve original numbers while distinguishing single pre-exercise ice slurry/cold water comparisons, people/crossover conditions, time/temperature, pre-exercise/terminal times, exhaustion tests and real race/heat-illness events. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or preparation, ingestion, cooling, exercise, prevention or treatment instructions are created.", "criterion": "Material for Allocation, completion and condition/outcome denominators must be linked to the selected subclaim, parent context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Participant flow, observations by condition and outcome-specific denominators are unverified. This records needed materials; no new research was executed." }, { "item_id": "N23", "question_type": "Evidence condition", "question": "How were the effect of interest and early discontinuation handled?", "needed": "Within-person time-to-exhaustion effect and missingness", "role": "Required", "role_reason": "This condition connects Within-person time-to-exhaustion effect and missingness with selected running time to exhaustion, study population, original ice slurry/cold water, within-person crossover, environment, times, denominators, temperature and harms.", "application_exception": "Preserve original numbers while distinguishing single pre-exercise ice slurry/cold water comparisons, people/crossover conditions, time/temperature, pre-exercise/terminal times, exhaustion tests and real race/heat-illness events. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or preparation, ingestion, cooling, exercise, prevention or treatment instructions are created.", "criterion": "Material for Within-person time-to-exhaustion effect and missingness must be linked to the selected subclaim, parent context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Complete observation status, analysis population, missing-data handling and sensitivity analyses are unverified. This records needed materials; no new research was executed." }, { "item_id": "N24", "question_type": "Evidence condition", "question": "Was the primary/secondary hierarchy for time and temperature confirmed?", "needed": "Prespecified outcome hierarchy and multiple-outcome plan", "role": "Required", "role_reason": "This condition connects Prespecified outcome hierarchy and multiple-outcome plan with selected running time to exhaustion, study population, original ice slurry/cold water, within-person crossover, environment, times, denominators, temperature and harms.", "application_exception": "Preserve original numbers while distinguishing single pre-exercise ice slurry/cold water comparisons, people/crossover conditions, time/temperature, pre-exercise/terminal times, exhaustion tests and real race/heat-illness events. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or preparation, ingestion, cooling, exercise, prevention or treatment instructions are created.", "criterion": "Material for Prespecified outcome hierarchy and multiple-outcome plan must be linked to the selected subclaim, parent context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: The prespecified hierarchy and multiplicity plan for time and temperature are unverified. This records needed materials; no new research was executed." }, { "item_id": "N25", "question_type": "Evidence condition", "question": "Were registration, protocol and SAP read?", "needed": "Registration identifier and actual preserved/read materials", "role": "Required", "role_reason": "This condition connects Registration identifier and actual preserved/read materials with selected running time to exhaustion, study population, original ice slurry/cold water, within-person crossover, environment, times, denominators, temperature and harms.", "application_exception": "Preserve original numbers while distinguishing single pre-exercise ice slurry/cold water comparisons, people/crossover conditions, time/temperature, pre-exercise/terminal times, exhaustion tests and real race/heat-illness events. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or preparation, ingestion, cooling, exercise, prevention or treatment instructions are created.", "criterion": "Material for Registration identifier and actual preserved/read materials must be linked to the selected subclaim, parent context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Registration existence, identifier and prior-plan content are unverified. This records needed materials; no new research was executed." }, { "item_id": "N26", "question_type": "Evidence condition", "question": "What is the current scope of funding and commercial-involvement information?", "needed": "Funding, manufacturer involvement and original disclosures", "role": "Required", "role_reason": "This condition connects Funding, manufacturer involvement and original disclosures with selected running time to exhaustion, study population, original ice slurry/cold water, within-person crossover, environment, times, denominators, temperature and harms.", "application_exception": "Preserve original numbers while distinguishing single pre-exercise ice slurry/cold water comparisons, people/crossover conditions, time/temperature, pre-exercise/terminal times, exhaustion tests and real race/heat-illness events. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or preparation, ingestion, cooling, exercise, prevention or treatment instructions are created.", "criterion": "Material for Funding, manufacturer involvement and original disclosures must be linked to the selected subclaim, parent context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Funding details, in-kind support and original author conflict disclosures are unverified. This records needed materials; no new research was executed." }, { "item_id": "N27", "question_type": "Evidence condition", "question": "How are report slots, crossover conditions and study families linked?", "needed": "Links and overlap among the same bibliography, study and participants", "role": "Required", "role_reason": "This condition connects Links and overlap among the same bibliography, study and participants with selected running time to exhaustion, study population, original ice slurry/cold water, within-person crossover, environment, times, denominators, temperature and harms.", "application_exception": "Preserve original numbers while distinguishing single pre-exercise ice slurry/cold water comparisons, people/crossover conditions, time/temperature, pre-exercise/terminal times, exhaustion tests and real race/heat-illness events. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or preparation, ingestion, cooling, exercise, prevention or treatment instructions are created.", "criterion": "Material for Links and overlap among the same bibliography, study and participants must be linked to the selected subclaim, parent context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Relationships to other reports, unique-trial counts and unique-participant totals are unverified. This records needed materials; no new research was executed." }, { "item_id": "N28", "question_type": "Evidence condition", "question": "What current evidence supports direct replication and independent reproduction?", "needed": "Separate studies, populations, funding and protocols", "role": "Required", "role_reason": "This condition connects Separate studies, populations, funding and protocols with selected running time to exhaustion, study population, original ice slurry/cold water, within-person crossover, environment, times, denominators, temperature and harms.", "application_exception": "Preserve original numbers while distinguishing single pre-exercise ice slurry/cold water comparisons, people/crossover conditions, time/temperature, pre-exercise/terminal times, exhaustion tests and real race/heat-illness events. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or preparation, ingestion, cooling, exercise, prevention or treatment instructions are created.", "criterion": "Material for Separate studies, populations, funding and protocols must be linked to the selected subclaim, parent context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: The populations, study identities and overlap of separate independent reports are unverified. This records needed materials; no new research was executed." }, { "item_id": "N29", "question_type": "Evidence condition", "question": "Has applicability to other populations, formulations and exposures been confirmed?", "needed": "Heterogeneity by population, formulation, temperature and exposure", "role": "Supplementary", "role_reason": "This condition connects Heterogeneity by population, formulation, temperature and exposure with selected running time to exhaustion, study population, original ice slurry/cold water, within-person crossover, environment, times, denominators, temperature and harms.", "application_exception": "Preserve original numbers while distinguishing single pre-exercise ice slurry/cold water comparisons, people/crossover conditions, time/temperature, pre-exercise/terminal times, exhaustion tests and real race/heat-illness events. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or preparation, ingestion, cooling, exercise, prevention or treatment instructions are created.", "criterion": "Material for Heterogeneity by population, formulation, temperature and exposure must be linked to the selected subclaim, parent context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Subgroup/exposure-specific effects and direct comparisons are unverified. This records needed materials; no new research was executed." }, { "item_id": "N30", "question_type": "Evidence condition", "question": "How are acquisition, actual reading and hyperlinks represented?", "needed": "Stored summary versus access to external materials", "role": "Required", "role_reason": "This condition connects Stored summary versus access to external materials with selected running time to exhaustion, study population, original ice slurry/cold water, within-person crossover, environment, times, denominators, temperature and harms.", "application_exception": "Preserve original numbers while distinguishing single pre-exercise ice slurry/cold water comparisons, people/crossover conditions, time/temperature, pre-exercise/terminal times, exhaustion tests and real race/heat-illness events. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or preparation, ingestion, cooling, exercise, prevention or treatment instructions are created.", "criterion": "Material for Stored summary versus access to external materials must be linked to the selected subclaim, parent context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Current confirmation of original-paper content, methods and result tables remains incomplete. This records needed materials; no new research was executed." }, { "item_id": "N31", "question_type": "Evidence condition", "question": "How are the original Korean/English text, reference date and history preserved?", "needed": "Original bilingual text, reference date, empty correction/deliberation records and historical axes", "role": "Required", "role_reason": "This condition connects Original bilingual text, reference date, empty correction/deliberation records and historical axes with selected running time to exhaustion, study population, original ice slurry/cold water, within-person crossover, environment, times, denominators, temperature and harms.", "application_exception": "Preserve original numbers while distinguishing single pre-exercise ice slurry/cold water comparisons, people/crossover conditions, time/temperature, pre-exercise/terminal times, exhaustion tests and real race/heat-illness events. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or preparation, ingestion, cooling, exercise, prevention or treatment instructions are created.", "criterion": "Material for Original bilingual text, reference date, empty correction/deliberation records and historical axes must be linked to the selected subclaim, parent context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Detailed external-paper translation and correction-history comparisons were not performed now. This records needed materials; no new research was executed." }, { "item_id": "N32", "question_type": "Evidence condition", "question": "How were harm events collected?", "needed": "Adverse-event definitions, active/passive collection and stopping criteria", "role": "Supplementary", "role_reason": "This condition connects Adverse-event definitions, active/passive collection and stopping criteria with selected running time to exhaustion, study population, original ice slurry/cold water, within-person crossover, environment, times, denominators, temperature and harms.", "application_exception": "Preserve original numbers while distinguishing single pre-exercise ice slurry/cold water comparisons, people/crossover conditions, time/temperature, pre-exercise/terminal times, exhaustion tests and real race/heat-illness events. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or preparation, ingestion, cooling, exercise, prevention or treatment instructions are created.", "criterion": "Material for Adverse-event definitions, active/passive collection and stopping criteria must be linked to the selected subclaim, parent context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Adverse-event collection/classification, severity and clinical-event data are unverified. This records needed materials; no new research was executed." }, { "item_id": "N33", "question_type": "Evidence condition", "question": "Is gastrointestinal-discomfort wording an actual event result?", "needed": "Original caution statement versus reported events", "role": "Supplementary", "role_reason": "This condition connects Original caution statement versus reported events with selected running time to exhaustion, study population, original ice slurry/cold water, within-person crossover, environment, times, denominators, temperature and harms.", "application_exception": "Preserve original numbers while distinguishing single pre-exercise ice slurry/cold water comparisons, people/crossover conditions, time/temperature, pre-exercise/terminal times, exhaustion tests and real race/heat-illness events. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or preparation, ingestion, cooling, exercise, prevention or treatment instructions are created.", "criterion": "Material for Original caution statement versus reported events must be linked to the selected subclaim, parent context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Actual gastrointestinal discomfort, denominators by condition, severity and relatedness assessments are unverified. This records needed materials; no new research was executed." }, { "item_id": "N34", "question_type": "Evidence condition", "question": "Were harm timing and observation duration confirmed?", "needed": "Harm timing before/after exposure, during exercise and after exhaustion", "role": "Supplementary", "role_reason": "This condition connects Harm timing before/after exposure, during exercise and after exhaustion with selected running time to exhaustion, study population, original ice slurry/cold water, within-person crossover, environment, times, denominators, temperature and harms.", "application_exception": "Preserve original numbers while distinguishing single pre-exercise ice slurry/cold water comparisons, people/crossover conditions, time/temperature, pre-exercise/terminal times, exhaustion tests and real race/heat-illness events. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or preparation, ingestion, cooling, exercise, prevention or treatment instructions are created.", "criterion": "Material for Harm timing before/after exposure, during exercise and after exhaustion must be linked to the selected subclaim, parent context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Post-exhaustion follow-up, delayed symptoms and event timing are unverified. This records needed materials; no new research was executed." }, { "item_id": "N35", "question_type": "Evidence condition", "question": "Were harm comparisons and denominators by condition confirmed?", "needed": "Paired harm events, observation denominators and comparative estimates", "role": "Supplementary", "role_reason": "This condition connects Paired harm events, observation denominators and comparative estimates with selected running time to exhaustion, study population, original ice slurry/cold water, within-person crossover, environment, times, denominators, temperature and harms.", "application_exception": "Preserve original numbers while distinguishing single pre-exercise ice slurry/cold water comparisons, people/crossover conditions, time/temperature, pre-exercise/terminal times, exhaustion tests and real race/heat-illness events. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or preparation, ingestion, cooling, exercise, prevention or treatment instructions are created.", "criterion": "Material for Paired harm events, observation denominators and comparative estimates must be linked to the selected subclaim, parent context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Valid event-specific observations, denominators, condition contrasts and CIs are unverified. This records needed materials; no new research was executed." }, { "item_id": "N36", "question_type": "Evidence condition", "question": "Are alternative causes and common exposures distinguished in harm interpretation?", "needed": "Exercise duration, environment, baseline state and temperature", "role": "Supplementary", "role_reason": "This condition connects Exercise duration, environment, baseline state and temperature with selected running time to exhaustion, study population, original ice slurry/cold water, within-person crossover, environment, times, denominators, temperature and harms.", "application_exception": "Preserve original numbers while distinguishing single pre-exercise ice slurry/cold water comparisons, people/crossover conditions, time/temperature, pre-exercise/terminal times, exhaustion tests and real race/heat-illness events. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or preparation, ingestion, cooling, exercise, prevention or treatment instructions are created.", "criterion": "Material for Exercise duration, environment, baseline state and temperature must be linked to the selected subclaim, parent context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Time-matched comparisons, baseline state and separation of confounding from mediation are unverified. This records needed materials; no new research was executed." }, { "item_id": "N37", "question_type": "Evidence condition", "question": "Were harm-related withdrawals and missing observations confirmed?", "needed": "Participant flow, test discontinuation and reasons for missingness", "role": "Supplementary", "role_reason": "This condition connects Participant flow, test discontinuation and reasons for missingness with selected running time to exhaustion, study population, original ice slurry/cold water, within-person crossover, environment, times, denominators, temperature and harms.", "application_exception": "Preserve original numbers while distinguishing single pre-exercise ice slurry/cold water comparisons, people/crossover conditions, time/temperature, pre-exercise/terminal times, exhaustion tests and real race/heat-illness events. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or preparation, ingestion, cooling, exercise, prevention or treatment instructions are created.", "criterion": "Material for Participant flow, test discontinuation and reasons for missingness must be linked to the selected subclaim, parent context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Numbers, reasons and handling of withdrawal, discontinuation and missing observations are unverified. This records needed materials; no new research was executed." }, { "item_id": "N38", "question_type": "Evidence condition", "question": "Has independent harm evidence been acquired?", "needed": "Separate harm materials matching the same question", "role": "Supplementary", "role_reason": "This condition connects Separate harm materials matching the same question with selected running time to exhaustion, study population, original ice slurry/cold water, within-person crossover, environment, times, denominators, temperature and harms.", "application_exception": "Preserve original numbers while distinguishing single pre-exercise ice slurry/cold water comparisons, people/crossover conditions, time/temperature, pre-exercise/terminal times, exhaustion tests and real race/heat-illness events. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or preparation, ingestion, cooling, exercise, prevention or treatment instructions are created.", "criterion": "Material for Separate harm materials matching the same question must be linked to the selected subclaim, parent context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: The identity, population and exposure of independent harm studies, surveillance or event reports are unverified. This records needed materials; no new research was executed." }, { "item_id": "N39", "question_type": "Evidence condition", "question": "Were repeated, vulnerable-population and long-term harms confirmed?", "needed": "Single exposure in healthy men versus other exposures/populations", "role": "Supplementary", "role_reason": "This condition connects Single exposure in healthy men versus other exposures/populations with selected running time to exhaustion, study population, original ice slurry/cold water, within-person crossover, environment, times, denominators, temperature and harms.", "application_exception": "Preserve original numbers while distinguishing single pre-exercise ice slurry/cold water comparisons, people/crossover conditions, time/temperature, pre-exercise/terminal times, exhaustion tests and real race/heat-illness events. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or preparation, ingestion, cooling, exercise, prevention or treatment instructions are created.", "criterion": "Material for Single exposure in healthy men versus other exposures/populations must be linked to the selected subclaim, parent context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Direct harm results for repeated/long-term exposure or vulnerable populations are unverified. This records needed materials; no new research was executed." }, { "item_id": "N40", "question_type": "Evidence condition", "question": "Are temperature signals, clinical events and causal safety questions separated?", "needed": "Physiological measures versus heat-illness events and causality", "role": "Supplementary", "role_reason": "This condition connects Physiological measures versus heat-illness events and causality with selected running time to exhaustion, study population, original ice slurry/cold water, within-person crossover, environment, times, denominators, temperature and harms.", "application_exception": "Preserve original numbers while distinguishing single pre-exercise ice slurry/cold water comparisons, people/crossover conditions, time/temperature, pre-exercise/terminal times, exhaustion tests and real race/heat-illness events. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or preparation, ingestion, cooling, exercise, prevention or treatment instructions are created.", "criterion": "Material for Physiological measures versus heat-illness events and causality must be linked to the selected subclaim, parent context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Direct event comparisons, causal data and precision are unverified. This records needed materials; no new research was executed." }, { "item_id": "N41", "question_type": "Evidence condition", "question": "How are follow-up materials linked to the same question?", "needed": "Stored summary, condition versions, new-material events and original values", "role": "Supplementary", "role_reason": "This condition connects Stored summary, condition versions, new-material events and original values with selected running time to exhaustion, study population, original ice slurry/cold water, within-person crossover, environment, times, denominators, temperature and harms.", "application_exception": "Preserve original numbers while distinguishing single pre-exercise ice slurry/cold water comparisons, people/crossover conditions, time/temperature, pre-exercise/terminal times, exhaustion tests and real race/heat-illness events. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or preparation, ingestion, cooling, exercise, prevention or treatment instructions are created.", "criterion": "Material for Stored summary, condition versions, new-material events and original values must be linked to the selected subclaim, parent context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: No later original material or actual reading/change event is currently recorded. This records needed materials; no new research was executed." }, { "item_id": "N42", "question_type": "Evidence condition", "question": "Are historical candidate records distinguished from content review?", "needed": "Historical candidate records, production and incomplete content review", "role": "Supplementary", "role_reason": "This condition connects Historical candidate records, production and incomplete content review with selected running time to exhaustion, study population, original ice slurry/cold water, within-person crossover, environment, times, denominators, temperature and harms.", "application_exception": "Preserve original numbers while distinguishing single pre-exercise ice slurry/cold water comparisons, people/crossover conditions, time/temperature, pre-exercise/terminal times, exhaustion tests and real race/heat-illness events. No new arithmetic, effects, CIs, hypothetical examples, grades, independence certification or preparation, ingestion, cooling, exercise, prevention or treatment instructions are created.", "criterion": "Material for Historical candidate records, production and incomplete content review must be linked to the selected subclaim, parent context, same report/crossover trial, outcome units, times, comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Follow-up content-review/change decisions and final independence totals remain unconfirmed. This records needed materials; no new research was executed." } ] }