{
  "schema_version": "chamgap-public-criteria-1.0",
  "title": "Low-free-sugar diet × Eight-week MRI-PDFF liver-fat reduction",
  "language": "en",
  "translation_date": "2026-10-15",
  "criteria_version": "1.0",
  "criteria_date": "2026-10-06",
  "condition_origin": "Chamgap's own application conditions",
  "method_sources": [
    {
      "id": "M03",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03",
      "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13",
      "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.",
      "review_level": "Preserved method HTML copies; no current method-content re-review or official tool execution"
    },
    {
      "id": "M04",
      "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04",
      "section": "§4.5, §4.6.1–4.6.3, MECIR C42",
      "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.",
      "review_level": "Preserved method HTML copies; no current method-content re-review or official tool execution"
    },
    {
      "id": "M08",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08",
      "section": "§8.1–8.2.3, Table 8.2.a",
      "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.",
      "review_level": "Preserved method HTML copies; no current method-content re-review or official tool execution"
    },
    {
      "id": "M15",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15",
      "section": "§15.2.4, §15.3.1–15.3.3",
      "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.",
      "review_level": "Preserved method HTML copies; no current method-content re-review or official tool execution"
    },
    {
      "id": "M19",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19",
      "section": "§19.1.2, §19.2.1–19.2.4",
      "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.",
      "review_level": "Preserved method HTML copies; no current method-content re-review or official tool execution"
    }
  ],
  "status_dictionary": {
    "Met": "Status for necessary evidence confirmed after existing content review. No completion is declared in the current presentation.",
    "Partly verified": "Some information in the stored summary is linked into the table. External comparison/content review is not complete.",
    "Unverified": "The article leaves this unverified, or required material is absent from the current stored summary. This is distinct from zero, absence or safety.",
    "Review incomplete": "Existing content review remains incomplete.",
    "Not reported": "Not reported within the stored material actually read; not extended to the entire primary paper.",
    "Inaccessible": "Means an actual access failure. Access not attempted here is not assigned this state.",
    "Not applicable": "Not used as a substitute for an evidence gap.",
    "Conflicting data": "Requires an observed disagreement under the same comparison criteria; not automatically judged in this production.",
    "Insufficient evidence for the conditions": "Marks a gap in additional material required by the selected conditions; not a new efficacy grade."
  },
  "requirements": [
    {
      "item_id": "N01",
      "question_type": "Evidence condition",
      "question": "Selected eight-week MRI question and original grade",
      "needed": "Selected wording, note and grade versus the original parent verdict",
      "role": "Required",
      "role_reason": "This applied item distinguishes Selected wording, note and grade versus the original parent verdict to connect required material for the selected question with currently available material.",
      "application_exception": "Stay within the stored-summary scope of the selected diet, population, endpoint and duration. Do not substitute figures from other diets, trials or endpoints, or unread external material.",
      "criterion": "Original material and analysis scope concerning Selected wording, note and grade versus the original parent verdict must be provided, with unverified points distinguishable. Existing stored wording is linked; review of existing content remains incomplete.",
      "basis": "M03 §3.1, §3.2.1–3.2.4 question-clarification principles; detailed separation rules are internally designed; M04 §4.5, §4.6.3; limits of this material conversion follow the review scope and internal design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Record update events while distinguishing the MRI question from parent and long-term questions. This is a proposal; no new investigation, calculation or trial has been performed."
    },
    {
      "item_id": "N02",
      "question_type": "Evidence condition",
      "question": "Actual age, sex, disease and recruitment",
      "needed": "Eligibility, histology, baseline MRI, recruitment and denominators",
      "role": "Required",
      "role_reason": "This applied item distinguishes Eligibility, histology, baseline MRI, recruitment and denominators to connect required material for the selected question with currently available material.",
      "application_exception": "Stay within the stored-summary scope of the selected diet, population, endpoint and duration. Do not substitute figures from other diets, trials or endpoints, or unread external material.",
      "criterion": "Original material and analysis scope concerning Eligibility, histology, baseline MRI, recruitment and denominators must be provided, with unverified points distinguishable. Existing stored wording is linked; review of existing content remains incomplete.",
      "basis": "M03 §3.2.1; detailed population conditions are internally designed. M08 Table 8.2.a, M15 §15.3 and M19 §19.1.2–19.2.4; design-specific adaptations are internally designed.",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Propose subsequent material distinguishing diseases and populations. This is a proposal; no new investigation, calculation or trial has been performed."
    },
    {
      "item_id": "N03",
      "question_type": "Evidence condition",
      "question": "Two centers and the randomized population",
      "needed": "Separation of centers, people, groups and trials",
      "role": "Required",
      "role_reason": "This applied item distinguishes Separation of centers, people, groups and trials to connect required material for the selected question with currently available material.",
      "application_exception": "Stay within the stored-summary scope of the selected diet, population, endpoint and duration. Do not substitute figures from other diets, trials or endpoints, or unread external material.",
      "criterion": "Original material and analysis scope concerning Separation of centers, people, groups and trials must be provided, with unverified points distinguishable. Existing stored wording is linked; review of existing content remains incomplete.",
      "basis": "M04 §4.6.1–4.6.2 distinctions between studies and reports; cohort and outcome linkage is internal application; M03 §3.2.1; detailed population conditions are internally designed; M08 §8.1–8.2.3; internal application",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Propose subsequent material distinguishing centers from populations within the same trial. This is a proposal; no new investigation, calculation or trial has been performed."
    },
    {
      "item_id": "N04",
      "question_type": "Evidence condition",
      "question": "Identity of whole-household food provision",
      "needed": "Food environment, design, provision, contact and actual exposure",
      "role": "Required",
      "role_reason": "This applied item distinguishes Food environment, design, provision, contact and actual exposure to connect required material for the selected question with currently available material.",
      "application_exception": "Stay within the stored-summary scope of the selected diet, population, endpoint and duration. Do not substitute figures from other diets, trials or endpoints, or unread external material.",
      "criterion": "Original material and analysis scope concerning Food environment, design, provision, contact and actual exposure must be provided, with unverified points distinguishable. Existing stored wording is linked; review of existing content remains incomplete.",
      "basis": "M03 §3.2.2–3.2.3; Reverse-direction labels and assessment adaptation are Chamgap design; M03 §3.2.3 and M08 §8.2.2–8.2.3; Chamgap application",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Propose subsequent material linking the whole intervention and actual exposure. No menus or child-diet instructions are created. This is a proposal; no new investigation, calculation or trial has been performed."
    },
    {
      "item_id": "N05",
      "question_type": "Evidence condition",
      "question": "Free-sugar targets versus actual implementation",
      "needed": "Planned energy percentage, actual intake and accompanying dietary changes",
      "role": "Required",
      "role_reason": "This applied item distinguishes Planned energy percentage, actual intake and accompanying dietary changes to connect required material for the selected question with currently available material.",
      "application_exception": "Stay within the stored-summary scope of the selected diet, population, endpoint and duration. Do not substitute figures from other diets, trials or endpoints, or unread external material.",
      "criterion": "Original material and analysis scope concerning Planned energy percentage, actual intake and accompanying dietary changes must be provided, with unverified points distinguishable. Existing stored wording is linked; review of existing content remains incomplete.",
      "basis": "M03 §3.2.2–3.2.3; reverse-direction labels and checking adaptations are internally designed; M03 §3.2.3, M08 §8.2.2–8.2.3; internal application; M03 §3.2.1–3.2.4; dose, duration and effect-modification details are internally designed",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Propose subsequent material distinguishing targets from the actual whole diet. No intake or weight-management implementation instructions are given. This is a proposal; no new investigation, calculation or trial has been performed."
    },
    {
      "item_id": "N06",
      "question_type": "Evidence condition",
      "question": "Actual usual-diet comparator conditions",
      "needed": "Control diet, household and contact, concurrent management and exposure",
      "role": "Required",
      "role_reason": "This applied item distinguishes Control diet, household and contact, concurrent management and exposure to connect required material for the selected question with currently available material.",
      "application_exception": "Stay within the stored-summary scope of the selected diet, population, endpoint and duration. Do not substitute figures from other diets, trials or endpoints, or unread external material.",
      "criterion": "Original material and analysis scope concerning Control diet, household and contact, concurrent management and exposure must be provided, with unverified points distinguishable. Existing stored wording is linked; review of existing content remains incomplete.",
      "basis": "M03 §3.2.2–3.2.3; reverse-direction labels and testing adaptations are internally designed; M03 §3.2.3, M08 §8.2.2–8.2.3; internal application; M08 §8.1–8.2.3; internal application",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Propose subsequent material distinguishing the comparator from the whole intervention. This is a proposal; no new investigation, calculation or trial has been performed."
    },
    {
      "item_id": "N07",
      "question_type": "Evidence condition",
      "question": "Allocation, 20/20 and concealment",
      "needed": "Randomization, group denominators and allocation procedures",
      "role": "Required",
      "role_reason": "This applied item distinguishes Randomization, group denominators and allocation procedures to connect required material for the selected question with currently available material.",
      "application_exception": "Stay within the stored-summary scope of the selected diet, population, endpoint and duration. Do not substitute figures from other diets, trials or endpoints, or unread external material.",
      "criterion": "Original material and analysis scope concerning Randomization, group denominators and allocation procedures must be provided, with unverified points distinguishable. Existing stored wording is linked; review of existing content remains incomplete.",
      "basis": "M08 §8.1–8.2.3; own application; M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; design-specific adaptation is our own design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Propose subsequent material linking allocation and actual denominators. This is a proposal; no new investigation, calculation or trial has been performed."
    },
    {
      "item_id": "N08",
      "question_type": "Evidence condition",
      "question": "Open-label design and masked MRI assessment",
      "needed": "Who was blinded, and assessment and analysis conditions",
      "role": "Required",
      "role_reason": "This applied item distinguishes Who was blinded, and assessment and analysis conditions to connect required material for the selected question with currently available material.",
      "application_exception": "Stay within the stored-summary scope of the selected diet, population, endpoint and duration. Do not substitute figures from other diets, trials or endpoints, or unread external material.",
      "criterion": "Original material and analysis scope concerning Who was blinded, and assessment and analysis conditions must be provided, with unverified points distinguishable. Existing stored wording is linked; review of existing content remains incomplete.",
      "basis": "M08 Table 8.2.a and M03 §3.2.4; Chamgap adaptation; M08 §§8.1–8.2.3; Chamgap adaptation",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Propose subsequent material separating dietary exposure from imaging-assessment conditions. This is a proposal; no new investigation, calculation or trial has been performed."
    },
    {
      "item_id": "N09",
      "question_type": "Evidence condition",
      "question": "MRI-PDFF definition, measurement and week eight",
      "needed": "Image acquisition, fat fraction, units and visits",
      "role": "Required",
      "role_reason": "This applied item distinguishes Image acquisition, fat fraction, units and visits to connect required material for the selected question with currently available material.",
      "application_exception": "Stay within the stored-summary scope of the selected diet, population, endpoint and duration. Do not substitute figures from other diets, trials or endpoints, or unread external material.",
      "criterion": "Original material and analysis scope concerning Image acquisition, fat fraction, units and visits must be provided, with unverified points distinguishable. Existing stored wording is linked; review of existing content remains incomplete.",
      "basis": "M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are our own design; M08 Table 8.2.a, M03 §3.2.4; our own application",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Propose subsequent material disclosing measurement methods and endpoint units. This is a proposal; no new investigation, calculation or trial has been performed."
    },
    {
      "item_id": "N10",
      "question_type": "Evidence condition",
      "question": "Original baseline and week-eight group percentages",
      "needed": "Original group values, visits, denominators and distinctions between changes",
      "role": "Required",
      "role_reason": "This applied item distinguishes Original group values, visits, denominators and distinctions between changes to connect required material for the selected question with currently available material.",
      "application_exception": "Stay within the stored-summary scope of the selected diet, population, endpoint and duration. Do not substitute figures from other diets, trials or endpoints, or unread external material.",
      "criterion": "Original material and analysis scope concerning Original group values, visits, denominators and distinctions between changes must be provided, with unverified points distinguishable. Existing stored wording is linked; review of existing content remains incomplete.",
      "basis": "M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are Chamgap's own design; M08 §8.2.2, M15 §15.3.1; Chamgap's own application; M15 §15.3.1–15.3.3; Chamgap's own application",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Propose subsequent material separating group percentages from comparative estimands. This is a proposal; no new investigation, calculation or trial has been performed."
    },
    {
      "item_id": "N11",
      "question_type": "Evidence condition",
      "question": "Adjusted between-group -6.23 percentage points, CI and P value",
      "needed": "Estimand, absolute percentage points, adjustment and denominators",
      "role": "Required",
      "role_reason": "This applied item distinguishes Estimand, absolute percentage points, adjustment and denominators to connect required material for the selected question with currently available material.",
      "application_exception": "Stay within the stored-summary scope of the selected diet, population, endpoint and duration. Do not substitute figures from other diets, trials or endpoints, or unread external material.",
      "criterion": "Original material and analysis scope concerning Estimand, absolute percentage points, adjustment and denominators must be provided, with unverified points distinguishable. Existing stored wording is linked; review of existing content remains incomplete.",
      "basis": "M08 Table 8.2.a, M15 §15.3 and M19 §19.1.2–19.2.4; Design-specific adaptation is Chamgap design; M08 §8.2.2 and M15 §15.3.1; Chamgap application; M15 §15.3.1–15.3.3; Chamgap application",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Propose subsequent material linking original reported estimands and analysis specifications. No new arithmetic or CIs are created. This is a proposal; no new investigation, calculation or trial has been performed."
    },
    {
      "item_id": "N12",
      "question_type": "Evidence condition",
      "question": "Original about 6.2 versus the exact estimate",
      "needed": "Narrative summary, exact values, units and direction",
      "role": "Required",
      "role_reason": "This applied item distinguishes Narrative summary, exact values, units and direction to connect required material for the selected question with currently available material.",
      "application_exception": "Stay within the stored-summary scope of the selected diet, population, endpoint and duration. Do not substitute figures from other diets, trials or endpoints, or unread external material.",
      "criterion": "Original material and analysis scope concerning Narrative summary, exact values, units and direction must be provided, with unverified points distinguishable. Existing stored wording is linked; review of existing content remains incomplete.",
      "basis": "M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptation is internally designed; M04 §4.5, §4.6.3; current material-conversion limits follow the review scope and internal design; M15 §15.3.1–15.3.3; internal application",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Propose subsequent material distinguishing exact values from summary wording. This is a proposal; no new investigation, calculation or trial has been performed."
    },
    {
      "item_id": "N13",
      "question_type": "Evidence condition",
      "question": "Weight changes and additional adjustment",
      "needed": "Primary analysis, sensitivity analysis, weight and diet",
      "role": "Required",
      "role_reason": "This applied item distinguishes Primary analysis, sensitivity analysis, weight and diet to connect required material for the selected question with currently available material.",
      "application_exception": "Stay within the stored-summary scope of the selected diet, population, endpoint and duration. Do not substitute figures from other diets, trials or endpoints, or unread external material.",
      "criterion": "Original material and analysis scope concerning Primary analysis, sensitivity analysis, weight and diet must be provided, with unverified points distinguishable. Existing stored wording is linked; review of existing content remains incomplete.",
      "basis": "M08 §8.2.2, M15 §15.3.1; internal application; M03 §3.2.3, M08 §8.2.2–8.2.3; internal application; M15 §15.3.1–15.3.3; internal application",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Propose subsequent material separating weight changes from attribution to the whole diet. This is a proposal; no new investigation, calculation or trial has been performed."
    },
    {
      "item_id": "N14",
      "question_type": "Evidence condition",
      "question": "Concurrent household, food-environment and activity exposure",
      "needed": "Household support, energy, nutrients, activity and management",
      "role": "Required",
      "role_reason": "This applied item distinguishes Household support, energy, nutrients, activity and management to connect required material for the selected question with currently available material.",
      "application_exception": "Stay within the stored-summary scope of the selected diet, population, endpoint and duration. Do not substitute figures from other diets, trials or endpoints, or unread external material.",
      "criterion": "Original material and analysis scope concerning Household support, energy, nutrients, activity and management must be provided, with unverified points distinguishable. Existing stored wording is linked; review of existing content remains incomplete.",
      "basis": "M03 §3.2.3, M08 §8.2.2–8.2.3; internal application; M08 §8.2.2, M15 §15.3.1; internal application; M03 §3.2.2–3.2.3; reverse-direction labels and testing adaptations are internally designed",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Propose subsequent material linking concurrent exposure with MRI analyses. No diet or adolescent weight-management instructions are given. This is a proposal; no new investigation, calculation or trial has been performed."
    },
    {
      "item_id": "N15",
      "question_type": "Evidence condition",
      "question": "Complete follow-up versus endpoint-specific analysis",
      "needed": "Completion, group and imaging denominators, missingness and analysis populations",
      "role": "Required",
      "role_reason": "This applied item distinguishes Completion, group and imaging denominators, missingness and analysis populations to connect required material for the selected question with currently available material.",
      "application_exception": "Stay within the stored-summary scope of the selected diet, population, endpoint and duration. Do not substitute figures from other diets, trials or endpoints, or unread external material.",
      "criterion": "Original material and analysis scope concerning Completion, group and imaging denominators, missingness and analysis populations must be provided, with unverified points distinguishable. Existing stored wording is linked; review of existing content remains incomplete.",
      "basis": "M08 Table 8.2.a, M15 §15.3 and M19 §19.1.2–19.2.4; Design-specific adaptation is Chamgap design; M08 §8.2.2 and M15 §15.3.1; Chamgap application",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Propose subsequent material distinguishing completion from actual analysis data. This is a proposal; no new investigation, calculation or trial has been performed."
    },
    {
      "item_id": "N16",
      "question_type": "Evidence condition",
      "question": "Analysis models, baseline and center, and multiplicity",
      "needed": "Prespecified estimands, adjustment and complete testing plans",
      "role": "Required",
      "role_reason": "This applied item distinguishes Prespecified estimands, adjustment and complete testing plans to connect required material for the selected question with currently available material.",
      "application_exception": "Stay within the stored-summary scope of the selected diet, population, endpoint and duration. Do not substitute figures from other diets, trials or endpoints, or unread external material.",
      "criterion": "Original material and analysis scope concerning Prespecified estimands, adjustment and complete testing plans must be provided, with unverified points distinguishable. Existing stored wording is linked; review of existing content remains incomplete.",
      "basis": "M08 §8.2.2, M15 §15.3.1; Internal application; M08 Table 8.2.a, M04 §4.6.3; Internal application",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Propose subsequent material disclosing prespecified analyses and all findings. This is a proposal; no new investigation, calculation or trial has been performed."
    },
    {
      "item_id": "N17",
      "question_type": "Evidence condition",
      "question": "NCT identifier and actual registration access",
      "needed": "Original registration identifier, plans, dates and amendments",
      "role": "Required",
      "role_reason": "This applied item distinguishes Original registration identifier, plans, dates and amendments to connect required material for the selected question with currently available material.",
      "application_exception": "Stay within the stored-summary scope of the selected diet, population, endpoint and duration. Do not substitute figures from other diets, trials or endpoints, or unread external material.",
      "criterion": "Original material and analysis scope concerning Original registration identifier, plans, dates and amendments must be provided, with unverified points distinguishable. Existing stored wording is linked; review of existing content remains incomplete.",
      "basis": "Data collection and selection principles in M04 §4.5–4.6; separation of access from reading and the hyperlink contract are internally designed; M08 Table 8.2.a, M04 §4.6.3; internal application; M04 §4.5, §4.6.3; limits of this material conversion reflect the review scope and internal design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Propose subsequent material distinguishing original identifiers from actual access scope. This is a proposal; no new investigation, calculation or trial has been performed."
    },
    {
      "item_id": "N18",
      "question_type": "Evidence condition",
      "question": "Preservation scope of the prespecified MRI endpoint",
      "needed": "Primary-endpoint statement, original prespecified versions and hierarchy",
      "role": "Required",
      "role_reason": "This applied item distinguishes Primary-endpoint statement, original prespecified versions and hierarchy to connect required material for the selected question with currently available material.",
      "application_exception": "Stay within the stored-summary scope of the selected diet, population, endpoint and duration. Do not substitute figures from other diets, trials or endpoints, or unread external material.",
      "criterion": "Original material and analysis scope concerning Primary-endpoint statement, original prespecified versions and hierarchy must be provided, with unverified points distinguishable. Existing stored wording is linked; review of existing content remains incomplete.",
      "basis": "M08 Table 8.2.a, M04 §4.6.3; Chamgap application; M04 §4.5–4.6 principles for collecting and selecting materials; separation of access and reading and hyperlink rules are Chamgap's own design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Propose subsequent material distinguishing prespecification statements from original plans. This is a proposal; no new investigation, calculation or trial has been performed."
    },
    {
      "item_id": "N19",
      "question_type": "Evidence condition",
      "question": "Large effects versus clinical importance",
      "needed": "Relevance, measured changes, and individual and clinical effects",
      "role": "Required",
      "role_reason": "This applied item distinguishes Relevance, measured changes, and individual and clinical effects to connect required material for the selected question with currently available material.",
      "application_exception": "Stay within the stored-summary scope of the selected diet, population, endpoint and duration. Do not substitute figures from other diets, trials or endpoints, or unread external material.",
      "criterion": "Original material and analysis scope concerning Relevance, measured changes, and individual and clinical effects must be provided, with unverified points distinguishable. Existing stored wording is linked; review of existing content remains incomplete.",
      "basis": "M15 §15.3.1–15.3.3; Chamgap's own application; M03 §3.2.4; Chamgap's own limits on extension",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Propose subsequent research separating imaging effects from clinical outcomes. This is a proposal; no new investigation, calculation or trial has been performed."
    },
    {
      "item_id": "N20",
      "question_type": "Evidence condition",
      "question": "Long-term liver-disease events were not measured",
      "needed": "Imaging surrogate, eight weeks and clinical follow-up",
      "role": "Required",
      "role_reason": "This applied item distinguishes Imaging surrogate, eight weeks and clinical follow-up to connect required material for the selected question with currently available material.",
      "application_exception": "Stay within the stored-summary scope of the selected diet, population, endpoint and duration. Do not substitute figures from other diets, trials or endpoints, or unread external material.",
      "criterion": "Original material and analysis scope concerning Imaging surrogate, eight weeks and clinical follow-up must be provided, with unverified points distinguishable. Existing stored wording is linked; review of existing content remains incomplete.",
      "basis": "M03 §3.2.1–3.2.4; dose, persistence and effect-modification details are internally designed; M03 §3.2.4; internally defined extension boundaries; M04 §4.5, §4.6.3; current material-conversion limits follow the review scope and internal design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Propose subsequent research distinguishing imaging at different periods from clinical events. No treatment-replacement advice is created. This is a proposal; no new investigation, calculation or trial has been performed."
    },
    {
      "item_id": "N21",
      "question_type": "Evidence condition",
      "question": "Eight weeks versus sustained or repeated intervention",
      "needed": "Short-term follow-up, intervention end and long-term exposure",
      "role": "Required",
      "role_reason": "This applied item distinguishes Short-term follow-up, intervention end and long-term exposure to connect required material for the selected question with currently available material.",
      "application_exception": "Stay within the stored-summary scope of the selected diet, population, endpoint and duration. Do not substitute figures from other diets, trials or endpoints, or unread external material.",
      "criterion": "Original material and analysis scope concerning Short-term follow-up, intervention end and long-term exposure must be provided, with unverified points distinguishable. Existing stored wording is linked; review of existing content remains incomplete.",
      "basis": "M03 §§3.2.1–3.2.4; dose, durability and effect-modification details are Chamgap-designed; M03 §§3.2.2–3.2.3; reverse-direction labels and assessment adaptation are Chamgap-designed",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Propose subsequent research separating questions about other periods and intervention intensities. This is a proposal; no new investigation, calculation or trial has been performed."
    },
    {
      "item_id": "N22",
      "question_type": "Evidence condition",
      "question": "Applicability to other populations and simple advice",
      "needed": "Direct disease-, sex-, age- and intensity-specific material",
      "role": "Required",
      "role_reason": "This applied item distinguishes Direct disease-, sex-, age- and intensity-specific material to connect required material for the selected question with currently available material.",
      "application_exception": "Stay within the stored-summary scope of the selected diet, population, endpoint and duration. Do not substitute figures from other diets, trials or endpoints, or unread external material.",
      "criterion": "Original material and analysis scope concerning Direct disease-, sex-, age- and intensity-specific material must be provided, with unverified points distinguishable. Existing stored wording is linked; review of existing content remains incomplete.",
      "basis": "M03 §3.2.1; detailed population conditions are our own design; M03 §3.2.2–3.2.3; reverse-direction labels and test adaptations are our own design; M03 §3.2.1–3.2.4; dose, duration and effect-modification details are our own design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Propose separate material when population and intervention differ. No child or adolescent diets or liver-disease management instructions are given. This is a proposal; no new investigation, calculation or trial has been performed."
    },
    {
      "item_id": "N23",
      "question_type": "Evidence condition",
      "question": "References, centers, visits and the same cohort",
      "needed": "Reports, registration, two centers and repeated measurements",
      "role": "Required",
      "role_reason": "This applied item distinguishes Reports, registration, two centers and repeated measurements to connect required material for the selected question with currently available material.",
      "application_exception": "Stay within the stored-summary scope of the selected diet, population, endpoint and duration. Do not substitute figures from other diets, trials or endpoints, or unread external material.",
      "criterion": "Original material and analysis scope concerning Reports, registration, two centers and repeated measurements must be provided, with unverified points distinguishable. Existing stored wording is linked; review of existing content remains incomplete.",
      "basis": "Study/report distinction in M04 §4.6.1–4.6.2; Cohort/outcome linkage is Chamgap application; M04 §4.6.1–4.6.2 and M15 §15.3.1; Chamgap application",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Propose separate research with the same MRI specifications. No independence certification or aggregation is performed. This is a proposal; no new investigation, calculation or trial has been performed."
    },
    {
      "item_id": "N24",
      "question_type": "Evidence condition",
      "question": "Funding, support, product and author roles",
      "needed": "Original funding roles, supply, employment and COI material",
      "role": "Required",
      "role_reason": "This applied item distinguishes Original funding roles, supply, employment and COI material to connect required material for the selected question with currently available material.",
      "application_exception": "Stay within the stored-summary scope of the selected diet, population, endpoint and duration. Do not substitute figures from other diets, trials or endpoints, or unread external material.",
      "criterion": "Original material and analysis scope concerning Original funding roles, supply, employment and COI material must be provided, with unverified points distinguishable. Existing stored wording is linked; review of existing content remains incomplete.",
      "basis": "Chamgap's own conditions for independence and attribution. The official methodological sections used in this example do not validate every detail of these items.",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Propose subsequent material distinguishing support types and roles. This is a proposal; no new investigation, calculation or trial has been performed."
    },
    {
      "item_id": "N25",
      "question_type": "Harm-information gaps supplementing the efficacy table",
      "question": "Scope of complete follow-up and adverse-event statements",
      "needed": "Harm-event collection, exposure, denominators and follow-up",
      "role": "Supplementary",
      "role_reason": "This applied item distinguishes Harm-event collection, exposure, denominators and follow-up to connect required material for the selected question with currently available material.",
      "application_exception": "Address safety-material gaps for the selected subclaim. Diet, isolated-component or imaging findings, or parent safety wording do not determine safety or create harm incidence rates or new use instructions.",
      "criterion": "Original material and analysis scope concerning Harm-event collection, exposure, denominators and follow-up must be provided, with unverified points distinguishable. Existing stored wording is linked; review of existing content remains incomplete.",
      "basis": "M19 §19.1.2–19.2.4; internal application. M19 §19.1.2–19.2.4; detailed distinctions are internally designed. M19 §19.2 covers design-specific harm questions; detailed temporal relationships are internally designed. M19 §19.2.2–19.2.4 and M03 §3.2.3; internal application. M19 §19.1.2–19.2.4; internal application. M19 §19.2.2–19.2.4 considers design; detailed confounding records are internally designed. M19 §19.1.2–19.2.4 and M04 §4.6.3; internal application. M19 §19.1.2–19.2.4; internal application. Interpretation boundaries are internally defined, informed by M19 principles; no official causality tool is executed.",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Propose subsequent material collecting efficacy separately from safety during growth. No restrictive-diet or child-treatment instructions are created. This is a proposal; no new investigation, calculation or trial has been performed."
    },
    {
      "item_id": "N26",
      "question_type": "Evidence condition",
      "question": "Original grades, axes, languages, dates and corrections",
      "needed": "Parent C with 54 points versus subclaim C, original values and historical judgments",
      "role": "Required",
      "role_reason": "This applied item distinguishes Parent C with 54 points versus subclaim C, original values and historical judgments to connect required material for the selected question with currently available material.",
      "application_exception": "Stay within the stored-summary scope of the selected diet, population, endpoint and duration. Do not substitute figures from other diets, trials or endpoints, or unread external material.",
      "criterion": "Original material and analysis scope concerning Parent C with 54 points versus subclaim C, original values and historical judgments must be provided, with unverified points distinguishable. Existing stored wording is linked; review of existing content remains incomplete.",
      "basis": "M04 §4.5, §4.6.3; limits of this material conversion follow the review scope and internal design; M03 §3.1, §3.2.1–3.2.4 question-clarification principles; detailed separation rules are internally designed",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Update while separating original values, production dates and correction events. This is a proposal; no new investigation, calculation or trial has been performed."
    },
    {
      "item_id": "N27",
      "question_type": "Evidence condition",
      "question": "Historical verification versus actual reading",
      "needed": "Historical full-text and registration verification, stored summary and unread external material",
      "role": "Required",
      "role_reason": "This applied item distinguishes Historical full-text and registration verification, stored summary and unread external material to connect required material for the selected question with currently available material.",
      "application_exception": "Stay within the stored-summary scope of the selected diet, population, endpoint and duration. Do not substitute figures from other diets, trials or endpoints, or unread external material.",
      "criterion": "Original material and analysis scope concerning Historical full-text and registration verification, stored summary and unread external material must be provided, with unverified points distinguishable. Existing stored wording is linked; review of existing content remains incomplete.",
      "basis": "M04 §4.5–4.6 material collection/selection principles; acquisition/reading separation and hyperlink specifications are internally designed; M04 §4.5, §4.6.3; limits of this material conversion follow the review scope and internal design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Propose subsequent organization distinguishing history from actual access events. This is a proposal; no new investigation, calculation or trial has been performed."
    },
    {
      "item_id": "N28",
      "question_type": "Evidence condition",
      "question": "Material links, gaps and update conditions",
      "needed": "Links between summary reading, unread material and additional material",
      "role": "Required",
      "role_reason": "This applied item distinguishes Links between summary reading, unread material and additional material to connect required material for the selected question with currently available material.",
      "application_exception": "Stay within the stored-summary scope of the selected diet, population, endpoint and duration. Do not substitute figures from other diets, trials or endpoints, or unread external material.",
      "criterion": "Original material and analysis scope concerning Links between summary reading, unread material and additional material must be provided, with unverified points distinguishable. Existing stored wording is linked; review of existing content remains incomplete.",
      "basis": "M04 §4.5–4.6 covers material collection and selection; distinctions between access and reading and hyperlink specifications are internally designed. M04 §4.6.1–4.6.2 distinguishes studies and reports; cohort and outcome linkage is an internal application. M04 §4.5 and §4.6.3; current evidence-conversion limits reflect review scope and internal design.",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "If additional material is provided, record its original form and actual access scope when updating content. This is a proposal; no new investigation, calculation or trial has been performed."
    }
  ]
}