# Casein-derived MKP × ADAS-cog total score: Primary null finding and gaps in CIs and clinical thresholds Verdict 2980 · Evidence Check Stored-material review date: Not recorded Original evidence cut-off: 2026-08-26 Review-criteria version: 1.0 Public page/material preparation date: 2026-10-15 Clinical papers were not read directly; existing review summaries were checked. No new clinical-literature search was performed. Unverified does not mean that research is absent or that there is no effect. ## Assessment scope - Population: 268 community-dwelling Japanese adults aged 40 or older without dementia; intention-to-treat analysis, 134/134. Completion, withdrawal and observed denominators for the selected endpoint are not verified in detail. - Ingredient, formulation and route: Casein hydrolysate tablets containing the casein-derived peptide Met-Lys-Pro (MKP) - Dose: Original study exposure only: MKP 200 μg/day for 24 weeks. No cumulative dose calculation or advice on consuming MKP, milk or products. - Comparator: Dextrin placebo tablets, 134 participants; sensory matching, blinding and concurrent exposures are not verified in detail. - Measured outcome: Primary ADAS-cog total score at 24 weeks, distinguished from Orientation, other tests and clinical function - Duration: 24 weeks; actual adherence, discontinuation, visit-specific follow-up and follow-up after the study are not verified in detail. - Questions outside this scope: Promoting positive Orientation findings into primary total-score success, improved global cognition, dementia prevention or clinical function; Copying group-specific total-score values, d, P or CI limitations into subscale results; Rejudging within-group improvement as an additional effect versus placebo, equivalence, noninferiority or a zero effect; Adding the same paper, registration, people, groups, visits, subscales or related sheets as new independent trials or participants; New calculations, hypothetical quantities, effects, CIs, grades or independence certification, or instructions on MKP, milk or product consumption, cognition or dementia care, or replacement of treatment ## Checklist items ### N01 · Which existing total-score claim is being presented? Verification status: Partly verified Reading scope: Stored summary read; external abstract, full text, registration, protocol and SAP unread - Current findings: The selected wording is “Improved ADAS-cog total score”, with original subclaim grade D and a note that the baseline-adjusted result was null, P=0.302 and d=0.12. Absent subclaim score, status and axes are not filled with parent D30 values or axes. - Why unverified: An observation from the preserved summary that distinguishes selected and parent claims, paper and registration, and endpoint information. Detailed original data are unverified and review of existing content is incomplete; this is not a passed content review or clinical certification. - Reason for missing information: The selected total score's effect of interest, population, visit and review of the claim boundary. Original subclaim absences and parent context are retained separately. - Required materials and conditions: Separate the selected ADAS-cog total score and subclaim grade from parent values - Materials to obtain first: The selected total score's effect of interest, population, visit and review of the claim boundary. Original subclaim absences and parent context are retained separately. - Further research: Material needed: The selected total score's effect of interest, population, visit and review of the claim boundary. Original subclaim absences and parent context are retained separately. Only material requests and research needs are recorded; no retrieval or research is performed in this work. - Conditions for verification: Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Separate the selected ADAS-cog total score and subclaim grade from parent values. - Why this condition is needed: This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Separate the selected ADAS-cog total score and subclaim grade from parent values. - Application exceptions: Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced. - Remaining uncertainty: External original material has not been read and review of existing content is incomplete. Original grades, scores, axes and historical verification or independence statements are not promoted into a new verdict or certification. - Referenced methods: Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production. - Related sources: R01 ### N02 · Which population's cognitive results are these? Verification status: Partly verified Reading scope: Stored summary read; external abstract, full text, registration, protocol and SAP unread - Current findings: The population comprised 268 community-dwelling Japanese adults aged 40 or older without dementia. Results are not extended to people with dementia, all cognitive impairment, or other ages or regions. - Why unverified: An observation from the preserved summary that distinguishes selected and parent claims, paper and registration, and endpoint information. Detailed original data are unverified and review of existing content is incomplete; this is not a passed content review or clinical certification. - Reason for missing information: Original eligibility and exclusion criteria, cognitive-status classification, baseline characteristics, comorbidities and medication, and direct comparisons in other populations. - Required materials and conditions: Community-dwelling adults without dementia and eligibility scope - Materials to obtain first: Original eligibility and exclusion criteria, cognitive-status classification, baseline characteristics, comorbidities and medication, and direct comparisons in other populations. - Further research: Material needed: Original eligibility and exclusion criteria, cognitive-status classification, baseline characteristics, comorbidities and medication, and direct comparisons in other populations. Only material requests and research needs are recorded; no retrieval or research is performed in this work. - Conditions for verification: Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Community-dwelling adults without dementia and eligibility scope. - Why this condition is needed: This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Community-dwelling adults without dementia and eligibility scope. - Application exceptions: Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced. - Remaining uncertainty: External original material has not been read and review of existing content is incomplete. Original grades, scores, axes and historical verification or independence statements are not promoted into a new verdict or certification. - Referenced methods: Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production. - Related sources: R01 ### N03 · Are baseline scores distinguished from cognitive status? Verification status: Partly verified Reading scope: Stored summary read; external abstract, full text, registration, protocol and SAP unread - Current findings: Baseline total scores were MKP 4.08±2.17 and placebo 4.10±2.10. The absence of dementia and the scores are retained as separate information. These values are not used to newly establish normal cognition, MCI or dementia thresholds, or floor or ceiling effects. - Why unverified: An observation from the preserved summary that distinguishes selected and parent claims, paper and registration, and endpoint information. Detailed original data are unverified and review of existing content is incomplete; this is not a passed content review or clinical certification. - Reason for missing information: Original data on score range and direction, population-specific cognitive classification, distributions and baseline clinical function. No new score conversion or diagnosis. - Required materials and conditions: Baseline total scores and clinical diagnosis - Materials to obtain first: Original data on score range and direction, population-specific cognitive classification, distributions and baseline clinical function. No new score conversion or diagnosis. - Further research: Material needed: Original data on score range and direction, population-specific cognitive classification, distributions and baseline clinical function. No new score conversion or diagnosis. Only material requests and research needs are recorded; no retrieval or research is performed in this work. - Conditions for verification: Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Baseline total scores and clinical diagnosis. - Why this condition is needed: This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Baseline total scores and clinical diagnosis. - Application exceptions: Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced. - Remaining uncertainty: External original material has not been read and review of existing content is incomplete. Original grades, scores, axes and historical verification or independence statements are not promoted into a new verdict or certification. - Referenced methods: Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production. - Related sources: R01 ### N04 · Is the study ingredient equivalent to ordinary milk? Verification status: Partly verified Reading scope: Stored summary read; external abstract, full text, registration, protocol and SAP unread - Current findings: The original intervention was milk-casein-derived Met-Lys-Pro (MKP), 200 μg/day; MKP-containing casein-hydrolysate tablets were manufactured and supplied. This is not converted into an amount or equivalence of ordinary milk or other casein products. - Why unverified: An observation from the preserved summary that distinguishes selected and parent claims, paper and registration, and endpoint information. Detailed original data are unverified and review of existing content is incomplete; this is not a passed content review or clinical certification. - Reason for missing information: Original tablet composition, MKP quantification and manufacturing, other ingredients, adherence and product identity. The original dose identifies study exposure and is not consumption or product advice. - Required materials and conditions: MKP and the casein-hydrolysate study product - Materials to obtain first: Original tablet composition, MKP quantification and manufacturing, other ingredients, adherence and product identity. The original dose identifies study exposure and is not consumption or product advice. - Further research: Material needed: Original tablet composition, MKP quantification and manufacturing, other ingredients, adherence and product identity. The original dose identifies study exposure and is not consumption or product advice. Only material requests and research needs are recorded; no retrieval or research is performed in this work. - Conditions for verification: Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: MKP and the casein-hydrolysate study product. - Why this condition is needed: This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: MKP and the casein-hydrolysate study product. - Application exceptions: Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced. - Remaining uncertainty: External original material has not been read and review of existing content is incomplete. Original grades, scores, axes and historical verification or independence statements are not promoted into a new verdict or certification. - Referenced methods: Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production. - Related sources: R01 ### N05 · What were the control and group allocations? Verification status: Partly verified Reading scope: Stored summary read; external abstract, full text, registration, protocol and SAP unread - Current findings: 268 participants were allocated to MKP 200 μg/day or dextrin placebo, 134 in each group. The summary does not establish actual placebo-tablet details, sensory matching, blinding or concurrent exposures. - Why unverified: An observation from the preserved summary that distinguishes selected and parent claims, paper and registration, and endpoint information. Detailed original data are unverified and review of existing content is incomplete; this is not a passed content review or clinical certification. - Reason for missing information: Original placebo composition, tablet count and expectations, concurrent diet and medication, contact, adherence and allocation concealment. The same effect is not transferred to other controls. - Required materials and conditions: Dextrin placebo and actual control conditions - Materials to obtain first: Original placebo composition, tablet count and expectations, concurrent diet and medication, contact, adherence and allocation concealment. The same effect is not transferred to other controls. - Further research: Material needed: Original placebo composition, tablet count and expectations, concurrent diet and medication, contact, adherence and allocation concealment. The same effect is not transferred to other controls. Only material requests and research needs are recorded; no retrieval or research is performed in this work. - Conditions for verification: Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Dextrin placebo and actual control conditions. - Why this condition is needed: This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Dextrin placebo and actual control conditions. - Application exceptions: Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced. - Remaining uncertainty: External original material has not been read and review of existing content is incomplete. Original grades, scores, axes and historical verification or independence statements are not promoted into a new verdict or certification. - Referenced methods: Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production. - Related sources: R01 ### N06 · Is 24-week study exposure distinguished from actual use and follow-up? Verification status: Partly verified Reading scope: Stored summary read; external abstract, full text, registration, protocol and SAP unread - Current findings: Original study exposure was 200 μg/day for 24 weeks. Actual exposure, adherence, discontinuation, visit-specific measurements and persistence after the study are not verified in detail. No new cumulative dose or number of days is calculated. - Why unverified: An observation from the preserved summary that distinguishes selected and parent claims, paper and registration, and endpoint information. Detailed original data are unverified and review of existing content is incomplete; this is not a passed content review or clinical certification. - Reason for missing information: Group-specific actual exposure, adherence, discontinuation, measurement timing and poststudy follow-up. No long-term dementia-prevention or treatment instructions. - Required materials and conditions: Duration, adherence and persistence after the study - Materials to obtain first: Group-specific actual exposure, adherence, discontinuation, measurement timing and poststudy follow-up. No long-term dementia-prevention or treatment instructions. - Further research: Material needed: Group-specific actual exposure, adherence, discontinuation, measurement timing and poststudy follow-up. No long-term dementia-prevention or treatment instructions. Only material requests and research needs are recorded; no retrieval or research is performed in this work. - Conditions for verification: Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Duration, adherence and persistence after the study. - Why this condition is needed: This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Duration, adherence and persistence after the study. - Application exceptions: Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced. - Remaining uncertainty: External original material has not been read and review of existing content is incomplete. Original grades, scores, axes and historical verification or independence statements are not promoted into a new verdict or certification. - Referenced methods: Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production. - Related sources: R01 ### N07 · Does ITT for 268 participants mean everyone completed follow-up? Verification status: Partly verified Reading scope: Stored summary read; external abstract, full text, registration, protocol and SAP unread - Current findings: The existing evidence list records 268 randomized participants and ITT analysis (134/134). ITT is not recast as completion of 24 weeks by everyone or identical observed denominators for all outcomes. Actual completion, withdrawal and missingness are not verified in detail. - Why unverified: An observation from the preserved summary that distinguishes selected and parent claims, paper and registration, and endpoint information. Detailed original data are unverified and review of existing content is incomplete; this is not a passed content review or clinical certification. - Reason for missing information: Group-specific flow diagrams and reasons for completion or withdrawal, observed and analyzed denominators for total scores and visits, and missing-data handling. No new withdrawal count, rate or measurement total is calculated. - Required materials and conditions: Allocation, analysis, completion, withdrawal and endpoint-specific denominators - Materials to obtain first: Group-specific flow diagrams and reasons for completion or withdrawal, observed and analyzed denominators for total scores and visits, and missing-data handling. No new withdrawal count, rate or measurement total is calculated. - Further research: Material needed: Group-specific flow diagrams and reasons for completion or withdrawal, observed and analyzed denominators for total scores and visits, and missing-data handling. No new withdrawal count, rate or measurement total is calculated. Only material requests and research needs are recorded; no retrieval or research is performed in this work. - Conditions for verification: Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Allocation, analysis, completion, withdrawal and endpoint-specific denominators. - Why this condition is needed: This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Allocation, analysis, completion, withdrawal and endpoint-specific denominators. - Application exceptions: Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced. - Remaining uncertainty: External original material has not been read and review of existing content is incomplete. Original grades, scores, axes and historical verification or independence statements are not promoted into a new verdict or certification. - Referenced methods: Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production. - Related sources: R01 ### N08 · What do the original allocation and blinding statements say? Verification status: Partly verified Reading scope: Stored summary read; external abstract, full text, registration, protocol and SAP unread - Current findings: The original Korean and English texts record computer block randomization, blinding of participants, physicians, assessors and analysts, and analysis by assigned group. The original design statement is retained; this is not a new comparison of procedures or data or an official RoB certification. - Why unverified: An observation from the preserved summary that distinguishes selected and parent claims, paper and registration, and endpoint information. Detailed original data are unverified and review of existing content is incomplete; this is not a passed content review or clinical certification. - Reason for missing information: Original allocation-concealment and blinding implementation or unblinding records, intervention deviations, missingness and analysis processes. Company involvement and design strengths remain separate. - Required materials and conditions: Computer block allocation and multiple blinding roles - Materials to obtain first: Original allocation-concealment and blinding implementation or unblinding records, intervention deviations, missingness and analysis processes. Company involvement and design strengths remain separate. - Further research: Material needed: Original allocation-concealment and blinding implementation or unblinding records, intervention deviations, missingness and analysis processes. Company involvement and design strengths remain separate. Only material requests and research needs are recorded; no retrieval or research is performed in this work. - Conditions for verification: Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Computer block allocation and multiple blinding roles. - Why this condition is needed: This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Computer block allocation and multiple blinding roles. - Application exceptions: Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced. - Remaining uncertainty: External original material has not been read and review of existing content is incomplete. Original grades, scores, axes and historical verification or independence statements are not promoted into a new verdict or certification. - Referenced methods: Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production. - Related sources: R01 ### N09 · Which primary test was the total score? Verification status: Partly verified Reading scope: Stored summary read; external abstract, full text, registration, protocol and SAP unread - Current findings: The paper summary identifies the primary endpoint as ADAS-cog total score at 24 weeks. The preserved registration citation says ADAS-Jcog was the prespecified primary endpoint. No new external comparison of names, versions, exact measurement or hierarchy was performed. - Why unverified: An observation from the preserved summary that distinguishes selected and parent claims, paper and registration, and endpoint information. Detailed original data are unverified and review of existing content is incomplete; this is not a passed content review or clinical certification. - Reason for missing information: Exact test version, total-score calculation and direction, measurement timing, and specifications in the paper, registration and protocol. Different names are not automatically treated as equivalent. - Required materials and conditions: ADAS-cog total score and the registered ADAS-Jcog name - Materials to obtain first: Exact test version, total-score calculation and direction, measurement timing, and specifications in the paper, registration and protocol. Different names are not automatically treated as equivalent. - Further research: Material needed: Exact test version, total-score calculation and direction, measurement timing, and specifications in the paper, registration and protocol. Different names are not automatically treated as equivalent. Only material requests and research needs are recorded; no retrieval or research is performed in this work. - Conditions for verification: Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: ADAS-cog total score and the registered ADAS-Jcog name. - Why this condition is needed: This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: ADAS-cog total score and the registered ADAS-Jcog name. - Application exceptions: Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced. - Remaining uncertainty: External original material has not been read and review of existing content is incomplete. Original grades, scores, axes and historical verification or independence statements are not promoted into a new verdict or certification. - Referenced methods: Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production. - Related sources: R01, R02 ### N10 · Are before-and-after total scores separated from the between-group comparison? Verification status: Partly verified Reading scope: Stored summary read; external abstract, full text, registration, protocol and SAP unread - Current findings: Total scores were MKP 4.08±2.17 to 3.18±1.88 and placebo 4.10±2.10 to 3.43±2.10. These are retained separately from the original baseline-adjusted between-group P=0.302 and d=0.12. No new difference, ratio or CI is calculated from before-and-after values. - Why unverified: An observation from the preserved summary that distinguishes selected and parent claims, paper and registration, and endpoint information. Detailed original data are unverified and review of existing content is incomplete; this is not a passed content review or clinical certification. - Reason for missing information: Dispersion notation in the original table, group-specific analysis denominators, baseline-adjusted model, effect of interest and missing-data handling. The meaning of ± is not guessed. - Required materials and conditions: Original total scores and baseline-adjusted effects - Materials to obtain first: Dispersion notation in the original table, group-specific analysis denominators, baseline-adjusted model, effect of interest and missing-data handling. The meaning of ± is not guessed. - Further research: Material needed: Dispersion notation in the original table, group-specific analysis denominators, baseline-adjusted model, effect of interest and missing-data handling. The meaning of ± is not guessed. Only material requests and research needs are recorded; no retrieval or research is performed in this work. - Conditions for verification: Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Original total scores and baseline-adjusted effects. - Why this condition is needed: This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Original total scores and baseline-adjusted effects. - Application exceptions: Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced. - Remaining uncertainty: External original material has not been read and review of existing content is incomplete. Original grades, scores, axes and historical verification or independence statements are not promoted into a new verdict or certification. - Referenced methods: Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production. - Related sources: R01 ### N11 · What do the null total-score finding and small d limit? Verification status: Partly verified Reading scope: Stored summary read; external abstract, full text, registration, protocol and SAP unread - Current findings: The original baseline-adjusted total-score result, P=0.302 and d=0.12, was judged null. It is not rejudged as an exactly zero effect, equivalence, noninferiority or exclusion of a clinically important benefit. - Why unverified: An observation from the preserved summary that distinguishes selected and parent claims, paper and registration, and endpoint information. Detailed original data are unverified and review of existing content is incomplete; this is not a passed content review or clinical certification. - Reason for missing information: Effect-estimate definition, 95% CI, prespecified externally validated clinical threshold, uncertainty and importance. No new effect, CI or hypothetical example. - Required materials and conditions: Original P and d and unverified CIs and clinical importance - Materials to obtain first: Effect-estimate definition, 95% CI, prespecified externally validated clinical threshold, uncertainty and importance. No new effect, CI or hypothetical example. - Further research: Material needed: Effect-estimate definition, 95% CI, prespecified externally validated clinical threshold, uncertainty and importance. No new effect, CI or hypothetical example. Only material requests and research needs are recorded; no retrieval or research is performed in this work. - Conditions for verification: Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Original P and d and unverified CIs and clinical importance. - Why this condition is needed: This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Original P and d and unverified CIs and clinical importance. - Application exceptions: Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced. - Remaining uncertainty: External original material has not been read and review of existing content is incomplete. Original grades, scores, axes and historical verification or independence statements are not promoted into a new verdict or certification. - Referenced methods: Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production. - Related sources: R01 ### N12 · Were CIs and a prespecified clinical threshold reported? Verification status: Unverified Reading scope: Stored summary read; external abstract, full text, registration, protocol and SAP unread - Current findings: The original material explains that a 95% CI for the primary endpoint and a prespecified externally validated clinical threshold were not reported, so a meaningful benefit could not be excluded. This original reporting limitation is not recast as a current rereading of the full paper. - Why unverified: An observation from the preserved summary that distinguishes selected and parent claims, paper and registration, and endpoint information. Detailed original data are unverified and review of existing content is incomplete; this is not a passed content review or clinical certification. - Reason for missing information: Original effect estimates and intervals, clinical-threshold setting, plans and analysis data, or separate confirmatory evidence. A sample size of 268 alone does not certify precision or exclusion of benefit. - Required materials and conditions: Effect precision and clinical thresholds - Materials to obtain first: Original effect estimates and intervals, clinical-threshold setting, plans and analysis data, or separate confirmatory evidence. A sample size of 268 alone does not certify precision or exclusion of benefit. - Further research: Material needed: Original effect estimates and intervals, clinical-threshold setting, plans and analysis data, or separate confirmatory evidence. A sample size of 268 alone does not certify precision or exclusion of benefit. Only material requests and research needs are recorded; no retrieval or research is performed in this work. - Conditions for verification: Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Effect precision and clinical thresholds. - Why this condition is needed: This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Effect precision and clinical thresholds. - Application exceptions: Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced. - Remaining uncertainty: External original material has not been read and review of existing content is incomplete. Original grades, scores, axes and historical verification or independence statements are not promoted into a new verdict or certification. - Referenced methods: Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production. - Related sources: R01 ### N13 · Was improvement in both groups assigned to the ingredient? Verification status: Partly verified Reading scope: Stored summary read; external abstract, full text, registration, protocol and SAP unread - Current findings: The original reader answer and advertising interpretation attribute improvement in both groups to repeat testing and explain that it should not be assigned to a specific MKP effect. This retains the original interpretation, not a new mechanistic or causal verification. - Why unverified: An observation from the preserved summary that distinguishes selected and parent claims, paper and registration, and endpoint information. Detailed original data are unverified and review of existing content is incomplete; this is not a passed content review or clinical certification. - Reason for missing information: Original information on repeat testing, practice and expectations, within- and between-group analyses, effect of interest and concurrent exposures. No new product effect is calculated from within-group change. - Required materials and conditions: Repeat testing and additional effects versus placebo - Materials to obtain first: Original information on repeat testing, practice and expectations, within- and between-group analyses, effect of interest and concurrent exposures. No new product effect is calculated from within-group change. - Further research: Material needed: Original information on repeat testing, practice and expectations, within- and between-group analyses, effect of interest and concurrent exposures. No new product effect is calculated from within-group change. Only material requests and research needs are recorded; no retrieval or research is performed in this work. - Conditions for verification: Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Repeat testing and additional effects versus placebo. - Why this condition is needed: This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Repeat testing and additional effects versus placebo. - Application exceptions: Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced. - Remaining uncertainty: External original material has not been read and review of existing content is incomplete. Original grades, scores, axes and historical verification or independence statements are not promoted into a new verdict or certification. - Referenced methods: Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production. - Related sources: R01 ### N14 · Does positive Orientation replace the failed total score? Verification status: Partly verified Reading scope: Stored summary read; external abstract, full text, registration, protocol and SAP unread - Current findings: The original statement is retained: Orientation P=0.022 is a disclosed secondary result but does not overturn the null primary total score. Total-score P, d, group values or CI limitations are not copied into Orientation results. - Why unverified: An observation from the preserved summary that distinguishes selected and parent claims, paper and registration, and endpoint information. Detailed original data are unverified and review of existing content is incomplete; this is not a passed content review or clinical certification. - Reason for missing information: Original subscale results, hierarchy, prespecified plans, multiple comparisons, individual effects and CIs, and separate confirmation. These are not promoted into total-score or global-cognition efficacy. - Required materials and conditions: Separate the primary total score from the secondary subscale - Materials to obtain first: Original subscale results, hierarchy, prespecified plans, multiple comparisons, individual effects and CIs, and separate confirmation. These are not promoted into total-score or global-cognition efficacy. - Further research: Material needed: Original subscale results, hierarchy, prespecified plans, multiple comparisons, individual effects and CIs, and separate confirmation. These are not promoted into total-score or global-cognition efficacy. Only material requests and research needs are recorded; no retrieval or research is performed in this work. - Conditions for verification: Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Separate the primary total score from the secondary subscale. - Why this condition is needed: This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Separate the primary total score from the secondary subscale. - Application exceptions: Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced. - Remaining uncertainty: External original material has not been read and review of existing content is incomplete. Original grades, scores, axes and historical verification or independence statements are not promoted into a new verdict or certification. - Referenced methods: Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production. - Related sources: R01 ### N15 · Are complete results for other subscales and tests available? Verification status: Unverified Reading scope: Stored summary read; external abstract, full text, registration, protocol and SAP unread - Current findings: The preserved material describes the total score and Orientation. Other subscales and tests, the total number of tests, complete results and the multiplicity plan are not verified in detail. No new list or count of positive or null results is created. - Why unverified: An observation from the preserved summary that distinguishes selected and parent claims, paper and registration, and endpoint information. Detailed original data are unverified and review of existing content is incomplete; this is not a passed content review or clinical certification. - Reason for missing information: Complete result tables, measurement tools, registration, protocol, SAP, and testing or selective-reporting plans. Unread external material is not assumed to be unreported. - Required materials and conditions: Total score, individual subscales and other tests - Materials to obtain first: Complete result tables, measurement tools, registration, protocol, SAP, and testing or selective-reporting plans. Unread external material is not assumed to be unreported. - Further research: Material needed: Complete result tables, measurement tools, registration, protocol, SAP, and testing or selective-reporting plans. Unread external material is not assumed to be unreported. Only material requests and research needs are recorded; no retrieval or research is performed in this work. - Conditions for verification: Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Total score, individual subscales and other tests. - Why this condition is needed: This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Total score, individual subscales and other tests. - Application exceptions: Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced. - Remaining uncertainty: External original material has not been read and review of existing content is incomplete. Original grades, scores, axes and historical verification or independence statements are not promoted into a new verdict or certification. - Referenced methods: Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production. - Related sources: R01 ### N16 · Were total-score findings extended to dementia prevention or daily function? Verification status: Unverified Reading scope: Stored summary read; external abstract, full text, registration, protocol and SAP unread - Current findings: The original population was adults without dementia and the primary endpoint was ADAS-cog total score at 24 weeks. The preserved scope provides no separate direct results for dementia incidence, daily function or replacement of treatment. These are not established from total scores or subscale signals. - Why unverified: An observation from the preserved summary that distinguishes selected and parent claims, paper and registration, and endpoint information. Detailed original data are unverified and review of existing content is incomplete; this is not a passed content review or clinical certification. - Reason for missing information: Definitions, duration, group-specific denominators, effects and CIs for clinical function or dementia events actually measured, and direct longer-term follow-up. Unread material is not assumed to mean the outcome was not measured. - Required materials and conditions: Cognitive scores and clinical function or incidence outcomes - Materials to obtain first: Definitions, duration, group-specific denominators, effects and CIs for clinical function or dementia events actually measured, and direct longer-term follow-up. Unread material is not assumed to mean the outcome was not measured. - Further research: Material needed: Definitions, duration, group-specific denominators, effects and CIs for clinical function or dementia events actually measured, and direct longer-term follow-up. Unread material is not assumed to mean the outcome was not measured. Only material requests and research needs are recorded; no retrieval or research is performed in this work. - Conditions for verification: Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Cognitive scores and clinical function or incidence outcomes. - Why this condition is needed: This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Cognitive scores and clinical function or incidence outcomes. - Application exceptions: Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced. - Remaining uncertainty: External original material has not been read and review of existing content is incomplete. Original grades, scores, axes and historical verification or independence statements are not promoted into a new verdict or certification. - Referenced methods: Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production. - Related sources: R01 ### N17 · Were endpoints, visits or related sheets counted as separate replications? Verification status: Partly verified Reading scope: Stored summary read; external abstract, full text, registration, protocol and SAP unread - Current findings: Total score and Orientation are different outcomes from the same Yuda2020 report and 268-person, 24-week trial. The same people, groups, visits, subscales, registration and related sheets are not added as new independent trials or participants. - Why unverified: An observation from the preserved summary that distinguishes selected and parent claims, paper and registration, and endpoint information. Detailed original data are unverified and review of existing content is incomplete; this is not a passed content review or clinical certification. - Reason for missing information: Original analysis, registration and report identities and links between repeated measurements and cohorts. Document counts are distinguished from certified counts of unique trials or participants. - Required materials and conditions: Relationships between total scores and subscales in the same report and participants - Materials to obtain first: Original analysis, registration and report identities and links between repeated measurements and cohorts. Document counts are distinguished from certified counts of unique trials or participants. - Further research: Material needed: Original analysis, registration and report identities and links between repeated measurements and cohorts. Document counts are distinguished from certified counts of unique trials or participants. Only material requests and research needs are recorded; no retrieval or research is performed in this work. - Conditions for verification: Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Relationships between total scores and subscales in the same report and participants. - Why this condition is needed: This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Relationships between total scores and subscales in the same report and participants. - Application exceptions: Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced. - Remaining uncertainty: External original material has not been read and review of existing content is incomplete. Original grades, scores, axes and historical verification or independence statements are not promoted into a new verdict or certification. - Referenced methods: Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production. - Related sources: R01, R02 ### N18 · What is the scope of the original serious-adverse-event statement? Verification status: Partly verified Reading scope: Stored summary read; external abstract, full text, registration, protocol and SAP unread - Current findings: The original safety explanation states that no serious adverse event attributed to MKP was reported over 24 weeks and includes a milk-protein-allergy caution. The full preserved summary is retained; this is not extended to zero adverse events, long-term safety or safety in all populations. - Why unverified: An observation from the preserved summary that distinguishes selected and parent claims, paper and registration, and endpoint information. Detailed original data are unverified and review of existing content is incomplete; this is not a passed content review or clinical certification. - Reason for missing information: Group-specific AE and SAE collection methods, exposure and denominators, discontinuation, attribution, allergy populations and longer-term harms. No new product-consumption or treatment guidance. - Required materials and conditions: Related SAEs over 24 weeks, other harms and allergy - Materials to obtain first: Group-specific AE and SAE collection methods, exposure and denominators, discontinuation, attribution, allergy populations and longer-term harms. No new product-consumption or treatment guidance. - Further research: Material needed: Group-specific AE and SAE collection methods, exposure and denominators, discontinuation, attribution, allergy populations and longer-term harms. No new product-consumption or treatment guidance. Only material requests and research needs are recorded; no retrieval or research is performed in this work. - Conditions for verification: Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Related SAEs over 24 weeks, other harms and allergy. - Why this condition is needed: This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Related SAEs over 24 weeks, other harms and allergy. - Application exceptions: Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced. - Remaining uncertainty: External original material has not been read and review of existing content is incomplete. Original grades, scores, axes and historical verification or independence statements are not promoted into a new verdict or certification. - Referenced methods: Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production. - Related sources: R01 ### N19 · What materials were actually read in this work? Verification status: Partly verified Reading scope: Stored summary read; external abstract, full text, registration, protocol and SAP unread - Current findings: The complete parent summary was read for production and preserved in its original form. Summary reading refers to the stored summary; the external abstract, full paper, UMIN registration, protocol and SAP remain unread in this work. The existence of a URL is not promoted into reading. - Why unverified: An observation from the preserved summary that distinguishes selected and parent claims, paper and registration, and endpoint information. Detailed original data are unverified and review of existing content is incomplete; this is not a passed content review or clinical certification. - Reason for missing information: Records of actual acquisition and reading scope, versions and dates. No separate external-link click or access test was performed. - Required materials and conditions: Preserved-summary reading and external paper or registration status - Materials to obtain first: Records of actual acquisition and reading scope, versions and dates. No separate external-link click or access test was performed. - Further research: Material needed: Records of actual acquisition and reading scope, versions and dates. No separate external-link click or access test was performed. Only material requests and research needs are recorded; no retrieval or research is performed in this work. - Conditions for verification: Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Preserved-summary reading and external paper or registration status. - Why this condition is needed: This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Preserved-summary reading and external paper or registration status. - Application exceptions: Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced. - Remaining uncertainty: External original material has not been read and review of existing content is incomplete. Original grades, scores, axes and historical verification or independence statements are not promoted into a new verdict or certification. - Referenced methods: Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production. - Related sources: R01, R02 ### N20 · Are historical registration dates and primary-endpoint names distinguished from current reading? Verification status: Partly verified Reading scope: Stored summary read; external abstract, full text, registration, protocol and SAP unread - Current findings: The original Korean and English texts describe prospective registration, with disclosure on 2018-06-04 and a planned start on 2018-06-07. The registration citation describes prespecified ADAS-Jcog and manufacturer funding. Only original dates and statements are retained; actual start, versions and plan agreement are not newly verified. - Why unverified: An observation from the preserved summary that distinguishes selected and parent claims, paper and registration, and endpoint information. Detailed original data are unverified and review of existing content is incomplete; this is not a passed content review or clinical certification. - Reason for missing information: Original registration text and versions, disclosure, start and change dates, ADAS-Jcog naming and endpoint specifications, and funding compared with the paper. The original official URL is retained without clicking it. - Required materials and conditions: UMIN000032833 history and prespecified plans - Materials to obtain first: Original registration text and versions, disclosure, start and change dates, ADAS-Jcog naming and endpoint specifications, and funding compared with the paper. The original official URL is retained without clicking it. - Further research: Material needed: Original registration text and versions, disclosure, start and change dates, ADAS-Jcog naming and endpoint specifications, and funding compared with the paper. The original official URL is retained without clicking it. Only material requests and research needs are recorded; no retrieval or research is performed in this work. - Conditions for verification: Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: UMIN000032833 history and prespecified plans. - Why this condition is needed: This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: UMIN000032833 history and prespecified plans. - Application exceptions: Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced. - Remaining uncertainty: External original material has not been read and review of existing content is incomplete. Original grades, scores, axes and historical verification or independence statements are not promoted into a new verdict or certification. - Referenced methods: Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production. - Related sources: R01, R02 ### N21 · Were protocol, SAP, subscale and multiplicity plans acquired? Verification status: Unverified Reading scope: Stored summary read; external abstract, full text, registration, protocol and SAP unread - Current findings: Original registration and historical cross-checking statements are retained. The original protocol and SAP, versions and dates, subscale and multiplicity plans, and clinical thresholds have not been read in this work. A registration statement about the primary endpoint does not establish all secondary plans. - Why unverified: An observation from the preserved summary that distinguishes selected and parent claims, paper and registration, and endpoint information. Detailed original data are unverified and review of existing content is incomplete; this is not a passed content review or clinical certification. - Reason for missing information: Original protocol, SAP, amendments, all outcomes and analyses, multiplicity, clinical thresholds and public-disclosure timing. Unread external material is not assumed to mean a document is absent. - Required materials and conditions: Separate evidence for prespecified plans, analyses and changes - Materials to obtain first: Original protocol, SAP, amendments, all outcomes and analyses, multiplicity, clinical thresholds and public-disclosure timing. Unread external material is not assumed to mean a document is absent. - Further research: Material needed: Original protocol, SAP, amendments, all outcomes and analyses, multiplicity, clinical thresholds and public-disclosure timing. Unread external material is not assumed to mean a document is absent. Only material requests and research needs are recorded; no retrieval or research is performed in this work. - Conditions for verification: Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Separate evidence for prespecified plans, analyses and changes. - Why this condition is needed: This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Separate evidence for prespecified plans, analyses and changes. - Application exceptions: Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced. - Remaining uncertainty: External original material has not been read and review of existing content is incomplete. Original grades, scores, axes and historical verification or independence statements are not promoted into a new verdict or certification. - Referenced methods: Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production. - Related sources: R01, R02 ### N22 · Are company funding, product support, employee authors and research roles separated? Verification status: Partly verified Reading scope: Stored summary read; external abstract, full text, registration, protocol and SAP unread - Current findings: The source records Morinaga Milk study support, manufacture and supply of MKP-containing hydrolysate and placebo tablets, four employee authors N.Y., M.T., K.Y. and F.A., and a supervision fee for N.S. The original limitation that separate public cofunding, medical-writing and publication support were not reported is retained. Design, analysis and data-control details are not newly established. - Why unverified: An observation from the preserved summary that distinguishes selected and parent claims, paper and registration, and endpoint information. Detailed original data are unverified and review of existing content is incomplete; this is not a passed content review or clinical certification. - Reason for missing information: Individual original records of company funding and products, author employment and supervision fees, design, analysis, data control, other support and conflicts of interest. Absence of public support and all roles are not certified in this work. - Required materials and conditions: Four categories of Morinaga involvement and other support - Materials to obtain first: Individual original records of company funding and products, author employment and supervision fees, design, analysis, data control, other support and conflicts of interest. Absence of public support and all roles are not certified in this work. - Further research: Material needed: Individual original records of company funding and products, author employment and supervision fees, design, analysis, data control, other support and conflicts of interest. Absence of public support and all roles are not certified in this work. Only material requests and research needs are recorded; no retrieval or research is performed in this work. - Conditions for verification: Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Four categories of Morinaga involvement and other support. - Why this condition is needed: This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Four categories of Morinaga involvement and other support. - Application exceptions: Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced. - Remaining uncertainty: External original material has not been read and review of existing content is incomplete. Original grades, scores, axes and historical verification or independence statements are not promoted into a new verdict or certification. - Referenced methods: Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production. - Related sources: R01, R02 ### N23 · Are null, positive secondary and unverified findings distinguished? Verification status: Partly verified Reading scope: Stored summary read; external abstract, full text, registration, protocol and SAP unread - Current findings: The null original total-score result, P=.302 and d=.12, is retained alongside the positive secondary Orientation P=.022, which does not overturn failure of the total score. Unverified details of CIs, plans and denominators differ from unread external material. - Why unverified: An observation from the preserved summary that distinguishes selected and parent claims, paper and registration, and endpoint information. Detailed original data are unverified and review of existing content is incomplete; this is not a passed content review or clinical certification. - Reason for missing information: Original endpoint-specific tables, direct measurement and analysis, plans, clinical importance and actual access scope. Null is not replaced with zero effect or equivalence, and unread is not replaced with unreported. - Required materials and conditions: Total-score and subscale findings and material-access states - Materials to obtain first: Original endpoint-specific tables, direct measurement and analysis, plans, clinical importance and actual access scope. Null is not replaced with zero effect or equivalence, and unread is not replaced with unreported. - Further research: Material needed: Original endpoint-specific tables, direct measurement and analysis, plans, clinical importance and actual access scope. Null is not replaced with zero effect or equivalence, and unread is not replaced with unreported. Only material requests and research needs are recorded; no retrieval or research is performed in this work. - Conditions for verification: Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Total-score and subscale findings and material-access states. - Why this condition is needed: This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Total-score and subscale findings and material-access states. - Application exceptions: Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced. - Remaining uncertainty: External original material has not been read and review of existing content is incomplete. Original grades, scores, axes and historical verification or independence statements are not promoted into a new verdict or certification. - Referenced methods: Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production. - Related sources: R01 ### N24 · Were the paper and registration counted as separate clinical trials? Verification status: Partly verified Reading scope: Stored summary read; external abstract, full text, registration, protocol and SAP unread - Current findings: Parent verdict 2980 and the total-score and Orientation sheets share the same Yuda2020 paper, UMIN000032833 registration and 268-person, 24-week trial. The same people, groups, visits, total scores, subscales, references, registration and related sheets are not added as new independent trials or participants. Two linked documents comprise one clinical paper and one registration record, not certified counts of unique trials or participants. - Why unverified: An observation from the preserved summary that distinguishes selected and parent claims, paper and registration, and endpoint information. Detailed original data are unverified and review of existing content is incomplete; this is not a passed content review or clinical certification. - Reason for missing information: Original references, registration and links to the same cohort, analyses, visits and outcomes. Totals of unique trials and participants remain unrecorded. - Required materials and conditions: Report and registration linkage versus actual trials and participants - Materials to obtain first: Original references, registration and links to the same cohort, analyses, visits and outcomes. Totals of unique trials and participants remain unrecorded. - Further research: Material needed: Original references, registration and links to the same cohort, analyses, visits and outcomes. Totals of unique trials and participants remain unrecorded. Only material requests and research needs are recorded; no retrieval or research is performed in this work. - Conditions for verification: Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Report and registration linkage versus actual trials and participants. - Why this condition is needed: This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Report and registration linkage versus actual trials and participants. - Application exceptions: Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced. - Remaining uncertainty: External original material has not been read and review of existing content is incomplete. Original grades, scores, axes and historical verification or independence statements are not promoted into a new verdict or certification. - Referenced methods: Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production. - Related sources: R01, R02 ### N25 · Is there separate independent confirmation? Verification status: Unverified Reading scope: Stored summary read; external abstract, full text, registration, protocol and SAP unread - Current findings: The original parent replication axis R1 and independence axis I0 are retained. The paper, registration, subscales in the same participants and related sheets are not certified as new independent replications. No separate replication of harm findings is created in this work. - Why unverified: An observation from the preserved summary that distinguishes selected and parent claims, paper and registration, and endpoint information. Detailed original data are unverified and review of existing content is incomplete; this is not a passed content review or clinical certification. - Reason for missing information: Confirmatory evidence with question-specific prespecified plans, separate populations and controls, direct endpoints and durations, effects and CIs, and funding or author relationships. No new search or independence verdict. - Required materials and conditions: Distinguish a single manufacturer trial from independent replication - Materials to obtain first: Confirmatory evidence with question-specific prespecified plans, separate populations and controls, direct endpoints and durations, effects and CIs, and funding or author relationships. No new search or independence verdict. - Further research: Material needed: Confirmatory evidence with question-specific prespecified plans, separate populations and controls, direct endpoints and durations, effects and CIs, and funding or author relationships. No new search or independence verdict. Only material requests and research needs are recorded; no retrieval or research is performed in this work. - Conditions for verification: Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Distinguish a single manufacturer trial from independent replication. - Why this condition is needed: This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Distinguish a single manufacturer trial from independent replication. - Application exceptions: Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced. - Remaining uncertainty: External original material has not been read and review of existing content is incomplete. Original grades, scores, axes and historical verification or independence statements are not promoted into a new verdict or certification. - Referenced methods: Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production. - Related sources: R01 ### N26 · Are subclaim grades distinguished from original parent scores and axes? Verification status: Partly verified Reading scope: Stored summary read; external abstract, full text, registration, protocol and SAP unread - Current findings: The selected record's grade, note and Korean and English question wording are retained; absent subclaim score, status and axes remain unrecorded. Parent D30, Good safety and B/P/R1/I0/E0/B0/C0 are parent context and are not transferred to the subclaim. - Why unverified: An observation from the preserved summary that distinguishes selected and parent claims, paper and registration, and endpoint information. Detailed original data are unverified and review of existing content is incomplete; this is not a passed content review or clinical certification. - Reason for missing information: Review of subclaim and parent boundaries and actual correction records. No new score or grade, or official RoB2 or GRADE certification. - Required materials and conditions: Subclaim grade, note and absences versus parent D30 - Materials to obtain first: Review of subclaim and parent boundaries and actual correction records. No new score or grade, or official RoB2 or GRADE certification. - Further research: Material needed: Review of subclaim and parent boundaries and actual correction records. No new score or grade, or official RoB2 or GRADE certification. Only material requests and research needs are recorded; no retrieval or research is performed in this work. - Conditions for verification: Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Subclaim grade, note and absences versus parent D30. - Why this condition is needed: This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Subclaim grade, note and absences versus parent D30. - Application exceptions: Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced. - Remaining uncertainty: External original material has not been read and review of existing content is incomplete. Original grades, scores, axes and historical verification or independence statements are not promoted into a new verdict or certification. - Referenced methods: Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production. - Related sources: R01 ### N27 · Are both languages and absent structured fields preserved? Verification status: Partly verified Reading scope: Stored summary read; external abstract, full text, registration, protocol and SAP unread - Current findings: The parent Korean and English texts, evidence and citations, axes and original selected subclaim are retained in the full stored summary. Separate Korean and English classification fields are absent; no new fields are inserted into the original summary. No external comparison with the English paper was performed. - Why unverified: An observation from the preserved summary that distinguishes selected and parent claims, paper and registration, and endpoint information. Detailed original data are unverified and review of existing content is incomplete; this is not a passed content review or clinical certification. - Reason for missing information: Review material for language-specific terminology, endpoints, visits, original statements and absences. Application-condition descriptions are distinguished from the preserved original record. - Required materials and conditions: Korean and English originals and absent separate classification fields - Materials to obtain first: Review material for language-specific terminology, endpoints, visits, original statements and absences. Application-condition descriptions are distinguished from the preserved original record. - Further research: Material needed: Review material for language-specific terminology, endpoints, visits, original statements and absences. Application-condition descriptions are distinguished from the preserved original record. Only material requests and research needs are recorded; no retrieval or research is performed in this work. - Conditions for verification: Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Korean and English originals and absent separate classification fields. - Why this condition is needed: This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Korean and English originals and absent separate classification fields. - Application exceptions: Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced. - Remaining uncertainty: External original material has not been read and review of existing content is incomplete. Original grades, scores, axes and historical verification or independence statements are not promoted into a new verdict or certification. - Referenced methods: Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production. - Related sources: R01 ### N28 · Are the reference date, corrections and historical cross-checking separated from production? Verification status: Partly verified Reading scope: Stored summary read; external abstract, full text, registration, protocol and SAP unread - Current findings: The 2026-08-26 reference date, empty correction array and deliberation string, and historical cross-checking in the verdict-decision record are retained. The original date and history are not condition-freezing, application, production or completed-content-review dates. - Why unverified: An observation from the preserved summary that distinguishes selected and parent claims, paper and registration, and endpoint information. Detailed original data are unverified and review of existing content is incomplete; this is not a passed content review or clinical certification. - Reason for missing information: When actual new corrections or material arise, retain the original text and separate events, conditions, observations and verdict decisions for updates. Historical records are not treated as new quality review. - Required materials and conditions: Original 2026-08-26 reference date and empty corrections - Materials to obtain first: When actual new corrections or material arise, retain the original text and separate events, conditions, observations and verdict decisions for updates. Historical records are not treated as new quality review. - Further research: Material needed: When actual new corrections or material arise, retain the original text and separate events, conditions, observations and verdict decisions for updates. Historical records are not treated as new quality review. Only material requests and research needs are recorded; no retrieval or research is performed in this work. - Conditions for verification: Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Original 2026-08-26 reference date and empty corrections. - Why this condition is needed: This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Original 2026-08-26 reference date and empty corrections. - Application exceptions: Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced. - Remaining uncertainty: External original material has not been read and review of existing content is incomplete. Original grades, scores, axes and historical verification or independence statements are not promoted into a new verdict or certification. - Referenced methods: Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production. - Related sources: R01 ### N29 · Which direct material would fill the selected gaps? Verification status: Unverified Reading scope: Stored summary read; external abstract, full text, registration, protocol and SAP unread - Current findings: The primary total-score null finding and gaps in CIs and clinical thresholds are retained. Precision and clinical importance require direct comparative material for that total score; subscales cannot substitute. - Why unverified: An observation from the preserved summary that distinguishes selected and parent claims, paper and registration, and endpoint information. Detailed original data are unverified and review of existing content is incomplete; this is not a passed content review or clinical certification. - Reason for missing information: Question-specific prespecified direct effects and CIs, denominators, missingness, measurement, effects of interest, clinical thresholds, multiplicity, separate confirmation, longer-term clinical outcomes and harms. Only material needs are recorded; no research or retrieval is performed. - Required materials and conditions: Prespecified questions, direct effects, CIs, plans and follow-up - Materials to obtain first: Question-specific prespecified direct effects and CIs, denominators, missingness, measurement, effects of interest, clinical thresholds, multiplicity, separate confirmation, longer-term clinical outcomes and harms. Only material needs are recorded; no research or retrieval is performed. - Further research: Material needed: Question-specific prespecified direct effects and CIs, denominators, missingness, measurement, effects of interest, clinical thresholds, multiplicity, separate confirmation, longer-term clinical outcomes and harms. Only material needs are recorded; no research or retrieval is performed. Only material requests and research needs are recorded; no retrieval or research is performed in this work. - Conditions for verification: Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Prespecified questions, direct effects, CIs, plans and follow-up. - Why this condition is needed: This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Prespecified questions, direct effects, CIs, plans and follow-up. - Application exceptions: Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced. - Remaining uncertainty: External original material has not been read and review of existing content is incomplete. Original grades, scores, axes and historical verification or independence statements are not promoted into a new verdict or certification. - Referenced methods: Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production. - Related sources: R01 ### N30 · Are production, existing content review and practical instructions separated? Verification status: Partly verified Reading scope: Stored summary read; external abstract, full text, registration, protocol and SAP unread - Current findings: This is an application-condition record based on the preserved summary. Existing content and question-boundary review are incomplete; historical candidate pending and eligibility labels are retained as history. Existing review status is recorded as it stands. - Why unverified: An observation from the preserved summary that distinguishes selected and parent claims, paper and registration, and endpoint information. Detailed original data are unverified and review of existing content is incomplete; this is not a passed content review or clinical certification. - Reason for missing information: Existing content review and subsequent actual material and correction records. The original production performed no comparison of clinical source material, external reading, new calculations, grade changes or advice on MKP, milk or products, cognition or dementia care, or treatment replacement. - Required materials and conditions: Production request, historical candidate record and responsibility for existing content review - Materials to obtain first: Existing content review and subsequent actual material and correction records. The original production performed no comparison of clinical source material, external reading, new calculations, grade changes or advice on MKP, milk or products, cognition or dementia care, or treatment replacement. - Further research: Material needed: Existing content review and subsequent actual material and correction records. The original production performed no comparison of clinical source material, external reading, new calculations, grade changes or advice on MKP, milk or products, cognition or dementia care, or treatment replacement. Only material requests and research needs are recorded; no retrieval or research is performed in this work. - Conditions for verification: Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Production request, historical candidate record and responsibility for existing content review. - Why this condition is needed: This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Production request, historical candidate record and responsibility for existing content review. - Application exceptions: Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced. - Remaining uncertainty: External original material has not been read and review of existing content is incomplete. Original grades, scores, axes and historical verification or independence statements are not promoted into a new verdict or certification. - Referenced methods: Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production. - Related sources: R01 ## Evidence and sources ### R01 Yuda N, et al. Effect of the Casein-Derived Peptide Met-Lys-Pro on Cognitive Function in Community-Dwelling Adults Without Dementia. Clin Interv Aging. 2020;15:743-754. PMID: 32546992. [PubMed](https://pubmed.ncbi.nlm.nih.gov/32546992/) Materials actually read: Stored summary read; external abstract, full text, registration and plans unread Findings recorded in the summary: 4.08±2.17 to 3.18±1.88 versus 4.10±2.10 to 3.43±2.10; baseline-adjusted P=0.302, d=0.12; 95% CI not reported Record level: Total-score summary in the preserved evidence list; Orientation is linked separately to its subclaim and the original counterview. Independent replication: Parent verdict 2980 and the total-score and Orientation sheets share the same Yuda2020 paper, UMIN000032833 registration and 268-person, 24-week trial context. The same people, groups, visits, total score, subscales, references, registration and related sheets are not added as new independent trials or participants. R01, the paper, and R02, the registration, are documents linked by the same UMIN identifier, not certified counts of unique trials or participants or a certification of independence. | Material | Public availability | Access status | Actually read | Notes | |---|---|---|---|---| | Stored summary | A preserved local copy of the complete parent summary | Stored summary read | Summary read | Only original PubMed and official UMIN URLs and identifiers are retained. No new external reading, access, confirmation of prespecification or certification of fulfillment is claimed. Missing full-text or plan URLs are not guessed. | | External abstract | An original identifier, citation or needed-material entry; public availability and access details are unverified. | Unread; no access test performed | Not read | Only original PubMed and official UMIN URLs and identifiers are retained. No new external reading, access, confirmation of prespecification or certification of fulfillment is claimed. Missing full-text or plan URLs are not guessed. | | External full text | An original identifier, citation or needed-material entry; public availability and access details are unverified. | Unread; no access test performed | Not read | Only original PubMed and official UMIN URLs and identifiers are retained. No new external reading, access, confirmation of prespecification or certification of fulfillment is claimed. Missing full-text or plan URLs are not guessed. | | Original registration | An original identifier, citation or needed-material entry; public availability and access details are unverified. | Unread; no access test performed | Not read | Only original PubMed and official UMIN URLs and identifiers are retained. No new external reading, access, confirmation of prespecification or certification of fulfillment is claimed. Missing full-text or plan URLs are not guessed. | | Protocol/SAP | An original identifier, citation or needed-material entry; public availability and access details are unverified. | Unread; no access test performed | Not read | Only original PubMed and official UMIN URLs and identifiers are retained. No new external reading, access, confirmation of prespecification or certification of fulfillment is claimed. Missing full-text or plan URLs are not guessed. | ### R02 UMIN Clinical Trials Registry. UMIN000032833. [Official source](https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000037442) Materials actually read: Stored summary read; external abstract, full text, registration and plans unread Findings recorded in the summary: ADAS-Jcog was the prespecified primary endpoint, and public disclosure preceded the planned start. Record level: Existing citation statement about registration plans; not a new clinical effect or result Independent replication: Parent verdict 2980 and the total-score and Orientation sheets share the same Yuda2020 paper, UMIN000032833 registration and 268-person, 24-week trial context. The same people, groups, visits, total score, subscales, references, registration and related sheets are not added as new independent trials or participants. R01, the paper, and R02, the registration, are documents linked by the same UMIN identifier, not certified counts of unique trials or participants or a certification of independence. | Material | Public availability | Access status | Actually read | Notes | |---|---|---|---|---| | Stored summary | A preserved local copy of the complete parent summary | Stored summary read | Summary read | Only original PubMed and official UMIN URLs and identifiers are retained. No new external reading, access, confirmation of prespecification or certification of fulfillment is claimed. Missing full-text or plan URLs are not guessed. | | Original registration | An original identifier, citation or needed-material entry; public availability and access details are unverified. | Unread; no access test performed | Not read | Only original PubMed and official UMIN URLs and identifiers are retained. No new external reading, access, confirmation of prespecification or certification of fulfillment is claimed. Missing full-text or plan URLs are not guessed. | | registry_history | An original identifier, citation or needed-material entry; public availability and access details are unverified. | Unread; no access test performed | Not read | Only original PubMed and official UMIN URLs and identifiers are retained. No new external reading, access, confirmation of prespecification or certification of fulfillment is claimed. Missing full-text or plan URLs are not guessed. | | protocol | An original identifier, citation or needed-material entry; public availability and access details are unverified. | Unread; no access test performed | Not read | Only original PubMed and official UMIN URLs and identifiers are retained. No new external reading, access, confirmation of prespecification or certification of fulfillment is claimed. Missing full-text or plan URLs are not guessed. | | analysis_plan | An original identifier, citation or needed-material entry; public availability and access details are unverified. | Unread; no access test performed | Not read | Only original PubMed and official UMIN URLs and identifiers are retained. No new external reading, access, confirmation of prespecification or certification of fulfillment is claimed. Missing full-text or plan URLs are not guessed. | ## Review criteria and methods These are Chamgap's own application conditions, informed by the relevant sections of official methodological guidance. They do not constitute official assessment-tool certification or a new efficacy score. - M03 [Cochrane Handbook 6.5 (2024), chapter updated 2023-08](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03) · §3.1, §3.2.1–3.2.3, MECIR C5/C7/C13 · Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions. · Link preserved methodological application records; no current clinical-content reassessment or external-link verification was performed. - M04 [Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04) · §4.5, §4.6.1–4.6.3, MECIR C42 · Distinguish studies from reports and link them; do not omit a study solely because results are unreported. · Link preserved methodological application records; no current clinical-content reassessment or external-link verification was performed. - M08 [Cochrane Handbook 6.5 (2024), chapter updated 2019-10](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08) · §8.1–8.2.3, Table 8.2.a · Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting. · Link preserved methodological application records; no current clinical-content reassessment or external-link verification was performed. - M15 [Cochrane Handbook 6.5 (2024), chapter updated 2023-08](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15) · §15.2.4, §15.3.1–15.3.3 · Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision. · Link preserved methodological application records; no current clinical-content reassessment or external-link verification was performed. - M19 [Cochrane Handbook 6.5 (2024), chapter updated 2019-10](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19) · §19.1.2, §19.2.1–19.2.4 · Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates. · Link preserved methodological application records; no current clinical-content reassessment or external-link verification was performed. ## What the statuses mean - Partly verified: Some information exists in the preserved review summary; detailed original materials remain unverified. This does not certify a passed review or clinical efficacy. - Unverified: Detailed materials for the selected condition could not be established within the stored scope; this does not mean zero effect, zero studies or safety - Review incomplete: Review of existing content incomplete - Met: Use only within the relevant conditions after existing content review; no automatic designation in this preparation - Not reported: Distinguish only within materials actually read; do not turn unread external materials into unreported findings - Inaccessible: Not applied during this preparation because actual access was not tested - Not applicable: Use with a reason for non-applicability based on an explicit question boundary - Conflicting data: Judge after actual material comparison; review was not performed during this preparation - Insufficient evidence for the conditions: Do not use as a clinical grade encompassing currently unread materials ## Change history 2026-10-15 · Public page/materials 1.0. The public page and data were prepared from the existing 30 items. No new clinical search, verification-status change or scoring was performed.