{
  "schema_version": "chamgap-public-criteria-1.0",
  "title": "Casein-derived MKP × Orientation: Positive secondary finding and gaps in total-score and multiplicity evidence",
  "language": "en",
  "translation_date": "2026-10-15",
  "criteria_version": "1.0",
  "criteria_date": "2026-10-06",
  "condition_origin": "Chamgap's own application conditions",
  "method_sources": [
    {
      "id": "M03",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03",
      "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13",
      "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.",
      "review_level": "Link preserved methodological application records; no current clinical-content reassessment or external-link verification was performed."
    },
    {
      "id": "M04",
      "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04",
      "section": "§4.5, §4.6.1–4.6.3, MECIR C42",
      "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.",
      "review_level": "Link preserved methodological application records; no current clinical-content reassessment or external-link verification was performed."
    },
    {
      "id": "M08",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08",
      "section": "§8.1–8.2.3, Table 8.2.a",
      "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.",
      "review_level": "Link preserved methodological application records; no current clinical-content reassessment or external-link verification was performed."
    },
    {
      "id": "M15",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15",
      "section": "§15.2.4, §15.3.1–15.3.3",
      "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.",
      "review_level": "Link preserved methodological application records; no current clinical-content reassessment or external-link verification was performed."
    },
    {
      "id": "M19",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19",
      "section": "§19.1.2, §19.2.1–19.2.4",
      "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.",
      "review_level": "Link preserved methodological application records; no current clinical-content reassessment or external-link verification was performed."
    }
  ],
  "status_dictionary": {
    "Partly verified": "Some information exists in the preserved review summary; detailed original materials remain unverified. This does not certify a passed review or clinical efficacy.",
    "Unverified": "Detailed materials for the selected condition could not be established within the stored scope; this does not mean zero effect, zero studies or safety",
    "Review incomplete": "Review of existing content incomplete",
    "Met": "Use only within the relevant conditions after existing content review; no automatic designation in this preparation",
    "Not reported": "Distinguish only within materials actually read; do not turn unread external materials into unreported findings",
    "Inaccessible": "Not applied during this preparation because actual access was not tested",
    "Not applicable": "Use with a reason for non-applicability based on an explicit question boundary",
    "Conflicting data": "Judge after actual material comparison; review was not performed during this preparation",
    "Insufficient evidence for the conditions": "Do not use as a clinical grade encompassing currently unread materials"
  },
  "requirements": [
    {
      "item_id": "N01",
      "question_type": "Evidence condition",
      "question": "Which existing Orientation claim is being presented?",
      "needed": "Separate the selected subscale wording and subclaim grade from parent values",
      "role": "Required",
      "role_reason": "This is needed to connect separate the selected subscale wording and subclaim grade from parent values with the selected question, actual population, intervention and control, total scores and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms.",
      "application_exception": "Distinguish the secondary Orientation P value from unverified group-specific values, effects, CIs, comparison models, prespecified or exploratory hierarchy and multiplicity; also distinguish the null primary total score, other tests, daily function, baseline cognition, population, intervention, control, duration, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Present original data on separate the selected subscale wording and subclaim grade from parent values, together with the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Orientation's exact effect of interest, visit, hierarchy and review of the claim boundary. Parent scores or axes and total-score grade D are not used to overwrite subclaim values. Only the need for material or research is recorded; no new retrieval or research is performed."
    },
    {
      "item_id": "N02",
      "question_type": "Evidence condition",
      "question": "Which population's subscale results are these?",
      "needed": "Community-dwelling Japanese adults aged 40 or older without dementia",
      "role": "Required",
      "role_reason": "This is needed to connect community-dwelling Japanese adults aged 40 or older without dementia with the selected question, actual population, intervention and control, total scores and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms.",
      "application_exception": "Distinguish the secondary Orientation P value from unverified group-specific values, effects, CIs, comparison models, prespecified or exploratory hierarchy and multiplicity; also distinguish the null primary total score, other tests, daily function, baseline cognition, population, intervention, control, duration, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Present original data on community-dwelling Japanese adults aged 40 or older without dementia, together with the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Original eligibility and exclusion criteria, baseline cognition and clinical status, comorbidities and medication, and direct outcomes in other populations. Only the need for material or research is recorded; no new retrieval or research is performed."
    },
    {
      "item_id": "N03",
      "question_type": "Evidence condition",
      "question": "Are baseline total scores also baseline Orientation scores?",
      "needed": "Baseline distributions of total scores and subscale scores",
      "role": "Required",
      "role_reason": "This is needed to connect baseline distributions of total scores and subscale scores with the selected question, actual population, intervention and control, total scores and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms.",
      "application_exception": "Distinguish the secondary Orientation P value from unverified group-specific values, effects, CIs, comparison models, prespecified or exploratory hierarchy and multiplicity; also distinguish the null primary total score, other tests, daily function, baseline cognition, population, intervention, control, duration, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Present original data on baseline distributions of total scores and subscale scores, together with the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Original Orientation tables, score range and direction, baseline and final distributions, and analyses by clinical status. No new conversion between total and subscale scores or diagnosis. Only the need for material or research is recorded; no new retrieval or research is performed."
    },
    {
      "item_id": "N04",
      "question_type": "Evidence condition",
      "question": "Is study MKP distinguished from ordinary milk?",
      "needed": "Study tablets containing casein-derived MKP",
      "role": "Required",
      "role_reason": "This is needed to connect study tablets containing casein-derived MKP with the selected question, actual population, intervention and control, total scores and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms.",
      "application_exception": "Distinguish the secondary Orientation P value from unverified group-specific values, effects, CIs, comparison models, prespecified or exploratory hierarchy and multiplicity; also distinguish the null primary total score, other tests, daily function, baseline cognition, population, intervention, control, duration, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Present original data on study tablets containing casein-derived MKP, together with the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Original tablet composition, MKP quantification, other ingredients, manufacture and adherence, and product identity. Study exposure is identified without consumption or product advice. Only the need for material or research is recorded; no new retrieval or research is performed."
    },
    {
      "item_id": "N05",
      "question_type": "Evidence condition",
      "question": "What were the actual control and concurrent exposures?",
      "needed": "Dextrin placebo and conditions in both groups",
      "role": "Required",
      "role_reason": "This is needed to connect dextrin placebo and conditions in both groups with the selected question, actual population, intervention and control, total scores and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms.",
      "application_exception": "Distinguish the secondary Orientation P value from unverified group-specific values, effects, CIs, comparison models, prespecified or exploratory hierarchy and multiplicity; also distinguish the null primary total score, other tests, daily function, baseline cognition, population, intervention, control, duration, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Present original data on dextrin placebo and conditions in both groups, together with the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Placebo and active composition, blinding, concurrent exposures, contact and adherence. Original data specifying the subscale effect of interest for additional benefit versus placebo. Only the need for material or research is recorded; no new retrieval or research is performed."
    },
    {
      "item_id": "N06",
      "question_type": "Evidence condition",
      "question": "Is 24-week exposure distinguished from sustained improvement?",
      "needed": "Original duration, actual exposure and post-study follow-up",
      "role": "Required",
      "role_reason": "This is needed to connect original duration, actual exposure and follow-up after the study with the selected question, actual population, intervention and control, total scores and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms.",
      "application_exception": "Distinguish the secondary Orientation P value from unverified group-specific values, effects, CIs, comparison models, prespecified or exploratory hierarchy and multiplicity; also distinguish the null primary total score, other tests, daily function, baseline cognition, population, intervention, control, duration, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Present original data on original duration, actual exposure and follow-up after the study, together with the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Visit-specific subscale analyses, actual exposure, visits and discontinuation, and follow-up after the study. No cumulative dose, number of days, consumption advice or care instructions. Only the need for material or research is recorded; no new retrieval or research is performed."
    },
    {
      "item_id": "N07",
      "question_type": "Evidence condition",
      "question": "Are ITT denominators separated from observed subscale denominators?",
      "needed": "ITT for 268 participants and Orientation-specific missingness and completion",
      "role": "Required",
      "role_reason": "This is needed to connect ITT for 268 participants and Orientation-specific missingness and completion with the selected question, actual population, intervention and control, total scores and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms.",
      "application_exception": "Distinguish the secondary Orientation P value from unverified group-specific values, effects, CIs, comparison models, prespecified or exploratory hierarchy and multiplicity; also distinguish the null primary total score, other tests, daily function, baseline cognition, population, intervention, control, duration, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Present original data on ITT for 268 participants and Orientation-specific missingness and completion, together with the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Group-specific flow, observed and analyzed denominators by Orientation outcome and visit, reasons for withdrawal and missingness, and handling methods. No new denominator, withdrawal count or rate is calculated. Only the need for material or research is recorded; no new retrieval or research is performed."
    },
    {
      "item_id": "N08",
      "question_type": "Evidence condition",
      "question": "What exactly did Orientation measure?",
      "needed": "Subscale definition, scores and interpretation",
      "role": "Required",
      "role_reason": "This is needed to connect subscale definition, scores and interpretation with the selected question, actual population, intervention and control, total scores and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms.",
      "application_exception": "Distinguish the secondary Orientation P value from unverified group-specific values, effects, CIs, comparison models, prespecified or exploratory hierarchy and multiplicity; also distinguish the null primary total score, other tests, daily function, baseline cognition, population, intervention, control, duration, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Present original data on subscale definition, scores and interpretation, together with the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Original Orientation test definitions, items and calculations, assessment methods, version, prespecified plans and tables. The name alone is not substituted for measurement of global cognition or daily function. Only the need for material or research is recorded; no new retrieval or research is performed."
    },
    {
      "item_id": "N09",
      "question_type": "Evidence condition",
      "question": "Were subscale effect sizes and CIs provided?",
      "needed": "Orientation P value and unverified quantitative effects",
      "role": "Required",
      "role_reason": "This is needed to connect Orientation P value and unverified quantitative effects with the selected question, actual population, intervention and control, total scores and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms.",
      "application_exception": "Distinguish the secondary Orientation P value from unverified group-specific values, effects, CIs, comparison models, prespecified or exploratory hierarchy and multiplicity; also distinguish the null primary total score, other tests, daily function, baseline cognition, population, intervention, control, duration, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Present original data on Orientation P value and unverified quantitative effects, together with the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Original group-specific baseline and final Orientation values, effect of interest, effects and CIs, denominators, models and clinical importance. No new effect or CI is calculated from P alone. Only the need for material or research is recorded; no new retrieval or research is performed."
    },
    {
      "item_id": "N10",
      "question_type": "Evidence condition",
      "question": "Which comparison or model produced the subscale P value?",
      "needed": "Orientation effect of interest, within-group and between-group comparisons, and adjustment",
      "role": "Required",
      "role_reason": "This is needed to connect Orientation effect of interest, within-group and between-group comparisons, and adjustment with the selected question, actual population, intervention and control, total scores and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms.",
      "application_exception": "Distinguish the secondary Orientation P value from unverified group-specific values, effects, CIs, comparison models, prespecified or exploratory hierarchy and multiplicity; also distinguish the null primary total score, other tests, daily function, baseline cognition, population, intervention, control, duration, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Present original data on Orientation effect of interest, within-group and between-group comparisons, and adjustment, together with the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Exact subscale comparison, analysis population, baseline adjustment or repeated measures, effect of interest and original tables. No new between-group or within-group difference is calculated. Only the need for material or research is recorded; no new retrieval or research is performed."
    },
    {
      "item_id": "N11",
      "question_type": "Evidence condition",
      "question": "Is the null primary total score retained separately?",
      "needed": "Different findings for the global cognition total score and Orientation",
      "role": "Required",
      "role_reason": "This is needed to connect different findings for the global cognition total score and Orientation with the selected question, actual population, intervention and control, total scores and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms.",
      "application_exception": "Distinguish the secondary Orientation P value from unverified group-specific values, effects, CIs, comparison models, prespecified or exploratory hierarchy and multiplicity; also distinguish the null primary total score, other tests, daily function, baseline cognition, population, intervention, control, duration, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Present original data on different findings for the global cognition total score and Orientation, together with the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Original total-score and subscale outcomes, exact visits, denominators, prespecified hierarchy and plans. Subscale and total-score values and conclusions are not transferred to each other. Only the need for material or research is recorded; no new retrieval or research is performed."
    },
    {
      "item_id": "N12",
      "question_type": "Evidence condition",
      "question": "Are secondary and exploratory findings distinguished from prespecified plans?",
      "needed": "Relationship between the secondary subscale and registered primary endpoint",
      "role": "Required",
      "role_reason": "This is needed to connect relationship between the secondary subscale and registered primary endpoint with the selected question, actual population, intervention and control, total scores and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms.",
      "application_exception": "Distinguish the secondary Orientation P value from unverified group-specific values, effects, CIs, comparison models, prespecified or exploratory hierarchy and multiplicity; also distinguish the null primary total score, other tests, daily function, baseline cognition, population, intervention, control, duration, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Present original data on relationship between the secondary subscale and registered primary endpoint, together with the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Subscale lists and hierarchy, prespecification, amendments and disclosure dates in the complete registration, protocol and SAP. The subscale is not newly designated as a prespecified confirmatory endpoint. Only the need for material or research is recorded; no new retrieval or research is performed."
    },
    {
      "item_id": "N13",
      "question_type": "Evidence condition",
      "question": "Are multiplicity plans and adjustments verified?",
      "needed": "Testing specifications for multiple subscales and tests",
      "role": "Required",
      "role_reason": "This is needed to connect testing specifications for multiple subscales and tests with the selected question, actual population, intervention and control, total scores and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms.",
      "application_exception": "Distinguish the secondary Orientation P value from unverified group-specific values, effects, CIs, comparison models, prespecified or exploratory hierarchy and multiplicity; also distinguish the null primary total score, other tests, daily function, baseline cognition, population, intervention, control, duration, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Present original data on testing specifications for multiple subscales and tests, together with the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Complete outcome and endpoint lists, prespecified testing and multiplicity, adjustment methods, selective reporting, and original comparisons of the paper with plans. No new adjusted P value or hypothetical example. Only the need for material or research is recorded; no new retrieval or research is performed."
    },
    {
      "item_id": "N14",
      "question_type": "Evidence condition",
      "question": "Are total-score and Orientation numbers distinguished?",
      "needed": "Before-and-after total scores and d versus the subscale P value",
      "role": "Required",
      "role_reason": "This is needed to connect before-and-after total scores and d versus the subscale P value with the selected question, actual population, intervention and control, total scores and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms.",
      "application_exception": "Distinguish the secondary Orientation P value from unverified group-specific values, effects, CIs, comparison models, prespecified or exploratory hierarchy and multiplicity; also distinguish the null primary total score, other tests, daily function, baseline cognition, population, intervention, control, duration, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Present original data on before-and-after total scores and d versus the subscale P value, together with the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Original tables, scores, variance, effects and CIs, visits, denominators and models for each endpoint. Different subscales are not averaged or added together. Only the need for material or research is recorded; no new retrieval or research is performed."
    },
    {
      "item_id": "N15",
      "question_type": "Evidence condition",
      "question": "Have other subscale and test findings been newly filled in?",
      "needed": "Scope of all tests and subscales",
      "role": "Required",
      "role_reason": "This is needed to connect scope of all tests and subscales with the selected question, actual population, intervention and control, total scores and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms.",
      "application_exception": "Distinguish the secondary Orientation P value from unverified group-specific values, effects, CIs, comparison models, prespecified or exploratory hierarchy and multiplicity; also distinguish the null primary total score, other tests, daily function, baseline cognition, population, intervention, control, duration, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Present original data on scope of all tests and subscales, together with the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Complete outcome tables, test lists, primary and secondary plans, denominators and visits, and effects and CIs. No new subscale or test results are invented. Only the need for material or research is recorded; no new retrieval or research is performed."
    },
    {
      "item_id": "N16",
      "question_type": "Evidence condition",
      "question": "Is the repeat-testing interpretation automatically applied to the subscale?",
      "needed": "Original total-score interpretation and the Orientation comparison",
      "role": "Required",
      "role_reason": "This is needed to connect original total-score interpretation and the Orientation comparison with the selected question, actual population, intervention and control, total scores and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms.",
      "application_exception": "Distinguish the secondary Orientation P value from unverified group-specific values, effects, CIs, comparison models, prespecified or exploratory hierarchy and multiplicity; also distinguish the null primary total score, other tests, daily function, baseline cognition, population, intervention, control, duration, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Present original data on original total-score interpretation and the Orientation comparison, together with the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Endpoint-specific baseline and final values, practice effects and expectations, assessments, effects of interest and models, and original tables. Within-group improvement is not newly calculated as an ingredient-specific effect. Only the need for material or research is recorded; no new retrieval or research is performed."
    },
    {
      "item_id": "N17",
      "question_type": "Evidence condition",
      "question": "Is the subscale extended to global cognition, dementia prevention or clinical function?",
      "needed": "Directness of the selected subscale for clinical outcomes",
      "role": "Required",
      "role_reason": "This is needed to connect directness of the selected subscale for clinical outcomes with the selected question, actual population, intervention and control, total scores and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms.",
      "application_exception": "Distinguish the secondary Orientation P value from unverified group-specific values, effects, CIs, comparison models, prespecified or exploratory hierarchy and multiplicity; also distinguish the null primary total score, other tests, daily function, baseline cognition, population, intervention, control, duration, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Present original data on directness of the selected subscale for clinical outcomes, together with the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Actual definitions, measurements and follow-up, group-specific denominators, effects and CIs for clinical function or dementia events, and direct confirmatory data relevant to the question. Unread material is not treated as proof that outcomes were not measured. Only the need for material or research is recorded; no new retrieval or research is performed."
    },
    {
      "item_id": "N18",
      "question_type": "Evidence condition",
      "question": "Are the same design and people counted as separate independent replication?",
      "needed": "Total-score and subscale findings from the same randomized trial",
      "role": "Required",
      "role_reason": "This is needed to connect total-score and subscale findings from the same randomized trial with the selected question, actual population, intervention and control, total scores and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms.",
      "application_exception": "Distinguish the secondary Orientation P value from unverified group-specific values, effects, CIs, comparison models, prespecified or exploratory hierarchy and multiplicity; also distinguish the null primary total score, other tests, daily function, baseline cognition, population, intervention, control, duration, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Present original data on total-score and subscale findings from the same randomized trial, together with the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Original links among reports, registration, cohorts and analyses, and endpoint-specific denominators. Strong design statements are not converted into certification of subscale prespecification, confirmation or independence. Only the need for material or research is recorded; no new retrieval or research is performed."
    },
    {
      "item_id": "N19",
      "question_type": "Harm-information gaps supplementing the efficacy table",
      "question": "Is safety separate from subscale efficacy?",
      "needed": "Related serious adverse events over 24 weeks, allergy and long-term harms",
      "role": "Supplementary",
      "role_reason": "This is needed to connect related serious adverse events over 24 weeks, allergy and long-term harms with the selected question, actual population, intervention and control, total scores and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms.",
      "application_exception": "Distinguish the secondary Orientation P value from unverified group-specific values, effects, CIs, comparison models, prespecified or exploratory hierarchy and multiplicity; also distinguish the null primary total score, other tests, daily function, baseline cognition, population, intervention, control, duration, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Present original data on related serious adverse events over 24 weeks, allergy and long-term harms, together with the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Group-specific AE and SAE collection, attribution and discontinuation, exposure and denominators, and allergy and long-term data. No consumption or product advice, or cognition or dementia care instructions. Only the need for material or research is recorded; no new retrieval or research is performed."
    },
    {
      "item_id": "N20",
      "question_type": "Evidence condition",
      "question": "What materials were actually read in this work?",
      "needed": "Preserved-summary reading and external paper or registration status",
      "role": "Required",
      "role_reason": "This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Preserved-summary reading and external paper or registration status.",
      "application_exception": "Distinguish the secondary Orientation P value from unverified group-specific values, effects, CIs, comparison models, prespecified or exploratory hierarchy and multiplicity; also distinguish the null primary total score, other tests, daily function, baseline cognition, population, intervention, control, duration, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Preserved-summary reading and external paper or registration status.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Records of actual acquisition and reading scope, versions and dates. No separate external-link click or access test was performed. Only material requests and research needs are recorded; no retrieval or research is performed in this work."
    },
    {
      "item_id": "N21",
      "question_type": "Evidence condition",
      "question": "Are historical registration dates and primary-endpoint names distinguished from current reading?",
      "needed": "UMIN000032833 history and prespecified plans",
      "role": "Required",
      "role_reason": "This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: UMIN000032833 history and prespecified plans.",
      "application_exception": "Distinguish the secondary Orientation P value from unverified group-specific values, effects, CIs, comparison models, prespecified or exploratory hierarchy and multiplicity; also distinguish the null primary total score, other tests, daily function, baseline cognition, population, intervention, control, duration, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: UMIN000032833 history and prespecified plans.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Original registration text and versions, disclosure, start and change dates, ADAS-Jcog naming and endpoint specifications, and funding compared with the paper. The original official URL is retained without clicking it. Only material requests and research needs are recorded; no retrieval or research is performed in this work."
    },
    {
      "item_id": "N22",
      "question_type": "Evidence condition",
      "question": "Were protocol, SAP, subscale and multiplicity plans acquired?",
      "needed": "Separate evidence for prespecified plans, analyses and changes",
      "role": "Required",
      "role_reason": "This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Separate evidence for prespecified plans, analyses and changes.",
      "application_exception": "Distinguish the secondary Orientation P value from unverified group-specific values, effects, CIs, comparison models, prespecified or exploratory hierarchy and multiplicity; also distinguish the null primary total score, other tests, daily function, baseline cognition, population, intervention, control, duration, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Separate evidence for prespecified plans, analyses and changes.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Original protocol, SAP, amendments, all outcomes and analyses, multiplicity, clinical thresholds and public-disclosure timing. Unread external material is not assumed to mean a document is absent. Only material requests and research needs are recorded; no retrieval or research is performed in this work."
    },
    {
      "item_id": "N23",
      "question_type": "Evidence condition",
      "question": "Are company funding, product support, employee authors and research roles separated?",
      "needed": "Four categories of Morinaga involvement and other support",
      "role": "Required",
      "role_reason": "This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Four categories of Morinaga involvement and other support.",
      "application_exception": "Distinguish the secondary Orientation P value from unverified group-specific values, effects, CIs, comparison models, prespecified or exploratory hierarchy and multiplicity; also distinguish the null primary total score, other tests, daily function, baseline cognition, population, intervention, control, duration, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Four categories of Morinaga involvement and other support.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Individual original records of company funding and products, author employment and supervision fees, design, analysis, data control, other support and conflicts of interest. Absence of public support and all roles are not certified in this work. Only material requests and research needs are recorded; no retrieval or research is performed in this work."
    },
    {
      "item_id": "N24",
      "question_type": "Evidence condition",
      "question": "Are null, positive secondary and unverified findings distinguished?",
      "needed": "Total-score and subscale findings and material-access states",
      "role": "Required",
      "role_reason": "This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Total-score and subscale findings and material-access states.",
      "application_exception": "Distinguish the secondary Orientation P value from unverified group-specific values, effects, CIs, comparison models, prespecified or exploratory hierarchy and multiplicity; also distinguish the null primary total score, other tests, daily function, baseline cognition, population, intervention, control, duration, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Total-score and subscale findings and material-access states.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Original endpoint-specific tables, direct measurement and analysis, plans, clinical importance and actual access scope. Null is not replaced with zero effect or equivalence, and unread is not replaced with unreported. Only material requests and research needs are recorded; no retrieval or research is performed in this work."
    },
    {
      "item_id": "N25",
      "question_type": "Evidence condition",
      "question": "Were the paper and registration counted as separate clinical trials?",
      "needed": "Report and registration linkage versus actual trials and participants",
      "role": "Required",
      "role_reason": "This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Report and registration linkage versus actual trials and participants.",
      "application_exception": "Distinguish the secondary Orientation P value from unverified group-specific values, effects, CIs, comparison models, prespecified or exploratory hierarchy and multiplicity; also distinguish the null primary total score, other tests, daily function, baseline cognition, population, intervention, control, duration, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Report and registration linkage versus actual trials and participants.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Original references, registration and links to the same cohort, analyses, visits and outcomes. Totals of unique trials and participants remain unrecorded. Only material requests and research needs are recorded; no retrieval or research is performed in this work."
    },
    {
      "item_id": "N26",
      "question_type": "Evidence condition",
      "question": "Is there separate independent confirmation?",
      "needed": "Distinguish a single manufacturer trial from independent replication",
      "role": "Supplementary",
      "role_reason": "This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Distinguish a single manufacturer trial from independent replication.",
      "application_exception": "Distinguish the secondary Orientation P value from unverified group-specific values, effects, CIs, comparison models, prespecified or exploratory hierarchy and multiplicity; also distinguish the null primary total score, other tests, daily function, baseline cognition, population, intervention, control, duration, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Distinguish a single manufacturer trial from independent replication.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Confirmatory evidence with question-specific prespecified plans, separate populations and controls, direct endpoints and durations, effects and CIs, and funding or author relationships. No new search or independence verdict. Only material requests and research needs are recorded; no retrieval or research is performed in this work."
    },
    {
      "item_id": "N27",
      "question_type": "Evidence condition",
      "question": "Are subclaim grades distinguished from original parent scores and axes?",
      "needed": "Subclaim grade, note and absences versus parent D30",
      "role": "Required",
      "role_reason": "This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Subclaim grade, note and absences versus parent D30.",
      "application_exception": "Distinguish the secondary Orientation P value from unverified group-specific values, effects, CIs, comparison models, prespecified or exploratory hierarchy and multiplicity; also distinguish the null primary total score, other tests, daily function, baseline cognition, population, intervention, control, duration, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Subclaim grade, note and absences versus parent D30.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Review of subclaim and parent boundaries and actual correction records. No new score or grade, or official RoB2 or GRADE certification. Only material requests and research needs are recorded; no retrieval or research is performed in this work."
    },
    {
      "item_id": "N28",
      "question_type": "Evidence condition",
      "question": "Are both languages and absent structured fields preserved?",
      "needed": "Korean and English originals and absent separate classification fields",
      "role": "Required",
      "role_reason": "This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Korean and English originals and absent separate classification fields.",
      "application_exception": "Distinguish the secondary Orientation P value from unverified group-specific values, effects, CIs, comparison models, prespecified or exploratory hierarchy and multiplicity; also distinguish the null primary total score, other tests, daily function, baseline cognition, population, intervention, control, duration, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Korean and English originals and absent separate classification fields.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Review material for language-specific terminology, endpoints, visits, original statements and absences. Application-condition descriptions are distinguished from the preserved original record. Only material requests and research needs are recorded; no retrieval or research is performed in this work."
    },
    {
      "item_id": "N29",
      "question_type": "Evidence condition",
      "question": "Are the reference date, corrections and historical cross-checking separated from production?",
      "needed": "Original 2026-08-26 reference date and empty corrections",
      "role": "Required",
      "role_reason": "This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Original 2026-08-26 reference date and empty corrections.",
      "application_exception": "Distinguish the secondary Orientation P value from unverified group-specific values, effects, CIs, comparison models, prespecified or exploratory hierarchy and multiplicity; also distinguish the null primary total score, other tests, daily function, baseline cognition, population, intervention, control, duration, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Original 2026-08-26 reference date and empty corrections.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: When actual new corrections or material arise, retain the original text and separate events, conditions, observations and verdict decisions for updates. Historical records are not treated as new quality review. Only material requests and research needs are recorded; no retrieval or research is performed in this work."
    },
    {
      "item_id": "N30",
      "question_type": "Evidence condition",
      "question": "Which direct material would fill the selected gaps?",
      "needed": "Prespecified questions, direct effects, CIs, plans and follow-up",
      "role": "Supplementary",
      "role_reason": "This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Prespecified questions, direct effects, CIs, plans and follow-up.",
      "application_exception": "Distinguish the secondary Orientation P value from unverified group-specific values, effects, CIs, comparison models, prespecified or exploratory hierarchy and multiplicity; also distinguish the null primary total score, other tests, daily function, baseline cognition, population, intervention, control, duration, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Prespecified questions, direct effects, CIs, plans and follow-up.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Question-specific prespecified direct effects and CIs, denominators, missingness, measurement, effects of interest, clinical thresholds, multiplicity, separate confirmation, longer-term clinical outcomes and harms. Only material needs are recorded; no research or retrieval is performed. Only material requests and research needs are recorded; no retrieval or research is performed in this work."
    },
    {
      "item_id": "N31",
      "question_type": "Evidence condition",
      "question": "Are production, existing content review and practical instructions separated?",
      "needed": "Production request, historical candidate record and responsibility for existing content review",
      "role": "Supplementary",
      "role_reason": "This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Production request, historical candidate record and responsibility for existing content review.",
      "application_exception": "Distinguish the secondary Orientation P value from unverified group-specific values, effects, CIs, comparison models, prespecified or exploratory hierarchy and multiplicity; also distinguish the null primary total score, other tests, daily function, baseline cognition, population, intervention, control, duration, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Production request, historical candidate record and responsibility for existing content review.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Existing content review and subsequent actual material and correction records. The original production performed no comparison of clinical source material, external reading, new calculations, grade changes or advice on MKP, milk or products, cognition or dementia care, or treatment replacement. Only material requests and research needs are recorded; no retrieval or research is performed in this work."
    }
  ]
}