{
  "schema_version": "chamgap-public-criteria-1.0",
  "title": "Casein-derived MKP × ADAS-cog total score: Primary null finding and gaps in CIs and clinical thresholds",
  "language": "en",
  "translation_date": "2026-10-15",
  "criteria_version": "1.0",
  "criteria_date": "2026-10-06",
  "condition_origin": "Chamgap's own application conditions",
  "method_sources": [
    {
      "id": "M03",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03",
      "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13",
      "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.",
      "review_level": "Link preserved methodological application records; no current clinical-content reassessment or external-link verification was performed."
    },
    {
      "id": "M04",
      "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04",
      "section": "§4.5, §4.6.1–4.6.3, MECIR C42",
      "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.",
      "review_level": "Link preserved methodological application records; no current clinical-content reassessment or external-link verification was performed."
    },
    {
      "id": "M08",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08",
      "section": "§8.1–8.2.3, Table 8.2.a",
      "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.",
      "review_level": "Link preserved methodological application records; no current clinical-content reassessment or external-link verification was performed."
    },
    {
      "id": "M15",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15",
      "section": "§15.2.4, §15.3.1–15.3.3",
      "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.",
      "review_level": "Link preserved methodological application records; no current clinical-content reassessment or external-link verification was performed."
    },
    {
      "id": "M19",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19",
      "section": "§19.1.2, §19.2.1–19.2.4",
      "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.",
      "review_level": "Link preserved methodological application records; no current clinical-content reassessment or external-link verification was performed."
    }
  ],
  "status_dictionary": {
    "Partly verified": "Some information exists in the preserved review summary; detailed original materials remain unverified. This does not certify a passed review or clinical efficacy.",
    "Unverified": "Detailed materials for the selected condition could not be established within the stored scope; this does not mean zero effect, zero studies or safety",
    "Review incomplete": "Review of existing content incomplete",
    "Met": "Use only within the relevant conditions after existing content review; no automatic designation in this preparation",
    "Not reported": "Distinguish only within materials actually read; do not turn unread external materials into unreported findings",
    "Inaccessible": "Not applied during this preparation because actual access was not tested",
    "Not applicable": "Use with a reason for non-applicability based on an explicit question boundary",
    "Conflicting data": "Judge after actual material comparison; review was not performed during this preparation",
    "Insufficient evidence for the conditions": "Do not use as a clinical grade encompassing currently unread materials"
  },
  "requirements": [
    {
      "item_id": "N01",
      "question_type": "Evidence condition",
      "question": "Which existing total-score claim is being presented?",
      "needed": "Separate the selected ADAS-cog total score and subclaim grade from parent values",
      "role": "Required",
      "role_reason": "This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Separate the selected ADAS-cog total score and subclaim grade from parent values.",
      "application_exception": "Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Separate the selected ADAS-cog total score and subclaim grade from parent values.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: The selected total score's effect of interest, population, visit and review of the claim boundary. Original subclaim absences and parent context are retained separately. Only material requests and research needs are recorded; no retrieval or research is performed in this work."
    },
    {
      "item_id": "N02",
      "question_type": "Evidence condition",
      "question": "Which population's cognitive results are these?",
      "needed": "Community-dwelling adults without dementia and eligibility scope",
      "role": "Required",
      "role_reason": "This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Community-dwelling adults without dementia and eligibility scope.",
      "application_exception": "Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Community-dwelling adults without dementia and eligibility scope.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Original eligibility and exclusion criteria, cognitive-status classification, baseline characteristics, comorbidities and medication, and direct comparisons in other populations. Only material requests and research needs are recorded; no retrieval or research is performed in this work."
    },
    {
      "item_id": "N03",
      "question_type": "Evidence condition",
      "question": "Are baseline scores distinguished from cognitive status?",
      "needed": "Baseline total scores and clinical diagnosis",
      "role": "Required",
      "role_reason": "This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Baseline total scores and clinical diagnosis.",
      "application_exception": "Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Baseline total scores and clinical diagnosis.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Original data on score range and direction, population-specific cognitive classification, distributions and baseline clinical function. No new score conversion or diagnosis. Only material requests and research needs are recorded; no retrieval or research is performed in this work."
    },
    {
      "item_id": "N04",
      "question_type": "Evidence condition",
      "question": "Is the study ingredient equivalent to ordinary milk?",
      "needed": "MKP and the casein-hydrolysate study product",
      "role": "Required",
      "role_reason": "This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: MKP and the casein-hydrolysate study product.",
      "application_exception": "Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: MKP and the casein-hydrolysate study product.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Original tablet composition, MKP quantification and manufacturing, other ingredients, adherence and product identity. The original dose identifies study exposure and is not consumption or product advice. Only material requests and research needs are recorded; no retrieval or research is performed in this work."
    },
    {
      "item_id": "N05",
      "question_type": "Evidence condition",
      "question": "What were the control and group allocations?",
      "needed": "Dextrin placebo and actual control conditions",
      "role": "Required",
      "role_reason": "This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Dextrin placebo and actual control conditions.",
      "application_exception": "Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Dextrin placebo and actual control conditions.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Original placebo composition, tablet count and expectations, concurrent diet and medication, contact, adherence and allocation concealment. The same effect is not transferred to other controls. Only material requests and research needs are recorded; no retrieval or research is performed in this work."
    },
    {
      "item_id": "N06",
      "question_type": "Evidence condition",
      "question": "Is 24-week study exposure distinguished from actual use and follow-up?",
      "needed": "Duration, adherence and persistence after the study",
      "role": "Required",
      "role_reason": "This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Duration, adherence and persistence after the study.",
      "application_exception": "Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Duration, adherence and persistence after the study.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Group-specific actual exposure, adherence, discontinuation, measurement timing and poststudy follow-up. No long-term dementia-prevention or treatment instructions. Only material requests and research needs are recorded; no retrieval or research is performed in this work."
    },
    {
      "item_id": "N07",
      "question_type": "Evidence condition",
      "question": "Does ITT for 268 participants mean everyone completed follow-up?",
      "needed": "Allocation, analysis, completion, withdrawal and endpoint-specific denominators",
      "role": "Required",
      "role_reason": "This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Allocation, analysis, completion, withdrawal and endpoint-specific denominators.",
      "application_exception": "Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Allocation, analysis, completion, withdrawal and endpoint-specific denominators.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Group-specific flow diagrams and reasons for completion or withdrawal, observed and analyzed denominators for total scores and visits, and missing-data handling. No new withdrawal count, rate or measurement total is calculated. Only material requests and research needs are recorded; no retrieval or research is performed in this work."
    },
    {
      "item_id": "N08",
      "question_type": "Evidence condition",
      "question": "What do the original allocation and blinding statements say?",
      "needed": "Computer block allocation and multiple blinding roles",
      "role": "Required",
      "role_reason": "This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Computer block allocation and multiple blinding roles.",
      "application_exception": "Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Computer block allocation and multiple blinding roles.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Original allocation-concealment and blinding implementation or unblinding records, intervention deviations, missingness and analysis processes. Company involvement and design strengths remain separate. Only material requests and research needs are recorded; no retrieval or research is performed in this work."
    },
    {
      "item_id": "N09",
      "question_type": "Evidence condition",
      "question": "Which primary test was the total score?",
      "needed": "ADAS-cog total score and the registered ADAS-Jcog name",
      "role": "Required",
      "role_reason": "This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: ADAS-cog total score and the registered ADAS-Jcog name.",
      "application_exception": "Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: ADAS-cog total score and the registered ADAS-Jcog name.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Exact test version, total-score calculation and direction, measurement timing, and specifications in the paper, registration and protocol. Different names are not automatically treated as equivalent. Only material requests and research needs are recorded; no retrieval or research is performed in this work."
    },
    {
      "item_id": "N10",
      "question_type": "Evidence condition",
      "question": "Are before-and-after total scores separated from the between-group comparison?",
      "needed": "Original total scores and baseline-adjusted effects",
      "role": "Required",
      "role_reason": "This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Original total scores and baseline-adjusted effects.",
      "application_exception": "Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Original total scores and baseline-adjusted effects.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Dispersion notation in the original table, group-specific analysis denominators, baseline-adjusted model, effect of interest and missing-data handling. The meaning of ± is not guessed. Only material requests and research needs are recorded; no retrieval or research is performed in this work."
    },
    {
      "item_id": "N11",
      "question_type": "Evidence condition",
      "question": "What do the null total-score finding and small d limit?",
      "needed": "Original P and d and unverified CIs and clinical importance",
      "role": "Required",
      "role_reason": "This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Original P and d and unverified CIs and clinical importance.",
      "application_exception": "Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Original P and d and unverified CIs and clinical importance.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Effect-estimate definition, 95% CI, prespecified externally validated clinical threshold, uncertainty and importance. No new effect, CI or hypothetical example. Only material requests and research needs are recorded; no retrieval or research is performed in this work."
    },
    {
      "item_id": "N12",
      "question_type": "Evidence condition",
      "question": "Were CIs and a prespecified clinical threshold reported?",
      "needed": "Effect precision and clinical thresholds",
      "role": "Required",
      "role_reason": "This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Effect precision and clinical thresholds.",
      "application_exception": "Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Effect precision and clinical thresholds.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Original effect estimates and intervals, clinical-threshold setting, plans and analysis data, or separate confirmatory evidence. A sample size of 268 alone does not certify precision or exclusion of benefit. Only material requests and research needs are recorded; no retrieval or research is performed in this work."
    },
    {
      "item_id": "N13",
      "question_type": "Evidence condition",
      "question": "Was improvement in both groups assigned to the ingredient?",
      "needed": "Repeat testing and additional effects versus placebo",
      "role": "Required",
      "role_reason": "This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Repeat testing and additional effects versus placebo.",
      "application_exception": "Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Repeat testing and additional effects versus placebo.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Original information on repeat testing, practice and expectations, within- and between-group analyses, effect of interest and concurrent exposures. No new product effect is calculated from within-group change. Only material requests and research needs are recorded; no retrieval or research is performed in this work."
    },
    {
      "item_id": "N14",
      "question_type": "Evidence condition",
      "question": "Does positive Orientation replace the failed total score?",
      "needed": "Separate the primary total score from the secondary subscale",
      "role": "Required",
      "role_reason": "This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Separate the primary total score from the secondary subscale.",
      "application_exception": "Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Separate the primary total score from the secondary subscale.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Original subscale results, hierarchy, prespecified plans, multiple comparisons, individual effects and CIs, and separate confirmation. These are not promoted into total-score or global-cognition efficacy. Only material requests and research needs are recorded; no retrieval or research is performed in this work."
    },
    {
      "item_id": "N15",
      "question_type": "Evidence condition",
      "question": "Are complete results for other subscales and tests available?",
      "needed": "Total score, individual subscales and other tests",
      "role": "Required",
      "role_reason": "This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Total score, individual subscales and other tests.",
      "application_exception": "Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Total score, individual subscales and other tests.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Complete result tables, measurement tools, registration, protocol, SAP, and testing or selective-reporting plans. Unread external material is not assumed to be unreported. Only material requests and research needs are recorded; no retrieval or research is performed in this work."
    },
    {
      "item_id": "N16",
      "question_type": "Evidence condition",
      "question": "Were total-score findings extended to dementia prevention or daily function?",
      "needed": "Cognitive scores and clinical function or incidence outcomes",
      "role": "Required",
      "role_reason": "This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Cognitive scores and clinical function or incidence outcomes.",
      "application_exception": "Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Cognitive scores and clinical function or incidence outcomes.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Definitions, duration, group-specific denominators, effects and CIs for clinical function or dementia events actually measured, and direct longer-term follow-up. Unread material is not assumed to mean the outcome was not measured. Only material requests and research needs are recorded; no retrieval or research is performed in this work."
    },
    {
      "item_id": "N17",
      "question_type": "Evidence condition",
      "question": "Were endpoints, visits or related sheets counted as separate replications?",
      "needed": "Relationships between total scores and subscales in the same report and participants",
      "role": "Required",
      "role_reason": "This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Relationships between total scores and subscales in the same report and participants.",
      "application_exception": "Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Relationships between total scores and subscales in the same report and participants.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Original analysis, registration and report identities and links between repeated measurements and cohorts. Document counts are distinguished from certified counts of unique trials or participants. Only material requests and research needs are recorded; no retrieval or research is performed in this work."
    },
    {
      "item_id": "N18",
      "question_type": "Harm-information gaps supplementing the efficacy table",
      "question": "What is the scope of the original serious-adverse-event statement?",
      "needed": "Related SAEs over 24 weeks, other harms and allergy",
      "role": "Supplementary",
      "role_reason": "This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Related SAEs over 24 weeks, other harms and allergy.",
      "application_exception": "Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Related SAEs over 24 weeks, other harms and allergy.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Group-specific AE and SAE collection methods, exposure and denominators, discontinuation, attribution, allergy populations and longer-term harms. No new product-consumption or treatment guidance. Only material requests and research needs are recorded; no retrieval or research is performed in this work."
    },
    {
      "item_id": "N19",
      "question_type": "Evidence condition",
      "question": "What materials were actually read in this work?",
      "needed": "Preserved-summary reading and external paper or registration status",
      "role": "Required",
      "role_reason": "This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Preserved-summary reading and external paper or registration status.",
      "application_exception": "Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Preserved-summary reading and external paper or registration status.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Records of actual acquisition and reading scope, versions and dates. No separate external-link click or access test was performed. Only material requests and research needs are recorded; no retrieval or research is performed in this work."
    },
    {
      "item_id": "N20",
      "question_type": "Evidence condition",
      "question": "Are historical registration dates and primary-endpoint names distinguished from current reading?",
      "needed": "UMIN000032833 history and prespecified plans",
      "role": "Required",
      "role_reason": "This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: UMIN000032833 history and prespecified plans.",
      "application_exception": "Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: UMIN000032833 history and prespecified plans.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Original registration text and versions, disclosure, start and change dates, ADAS-Jcog naming and endpoint specifications, and funding compared with the paper. The original official URL is retained without clicking it. Only material requests and research needs are recorded; no retrieval or research is performed in this work."
    },
    {
      "item_id": "N21",
      "question_type": "Evidence condition",
      "question": "Were protocol, SAP, subscale and multiplicity plans acquired?",
      "needed": "Separate evidence for prespecified plans, analyses and changes",
      "role": "Required",
      "role_reason": "This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Separate evidence for prespecified plans, analyses and changes.",
      "application_exception": "Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Separate evidence for prespecified plans, analyses and changes.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Original protocol, SAP, amendments, all outcomes and analyses, multiplicity, clinical thresholds and public-disclosure timing. Unread external material is not assumed to mean a document is absent. Only material requests and research needs are recorded; no retrieval or research is performed in this work."
    },
    {
      "item_id": "N22",
      "question_type": "Evidence condition",
      "question": "Are company funding, product support, employee authors and research roles separated?",
      "needed": "Four categories of Morinaga involvement and other support",
      "role": "Required",
      "role_reason": "This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Four categories of Morinaga involvement and other support.",
      "application_exception": "Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Four categories of Morinaga involvement and other support.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Individual original records of company funding and products, author employment and supervision fees, design, analysis, data control, other support and conflicts of interest. Absence of public support and all roles are not certified in this work. Only material requests and research needs are recorded; no retrieval or research is performed in this work."
    },
    {
      "item_id": "N23",
      "question_type": "Evidence condition",
      "question": "Are null, positive secondary and unverified findings distinguished?",
      "needed": "Total-score and subscale findings and material-access states",
      "role": "Required",
      "role_reason": "This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Total-score and subscale findings and material-access states.",
      "application_exception": "Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Total-score and subscale findings and material-access states.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Original endpoint-specific tables, direct measurement and analysis, plans, clinical importance and actual access scope. Null is not replaced with zero effect or equivalence, and unread is not replaced with unreported. Only material requests and research needs are recorded; no retrieval or research is performed in this work."
    },
    {
      "item_id": "N24",
      "question_type": "Evidence condition",
      "question": "Were the paper and registration counted as separate clinical trials?",
      "needed": "Report and registration linkage versus actual trials and participants",
      "role": "Required",
      "role_reason": "This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Report and registration linkage versus actual trials and participants.",
      "application_exception": "Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Report and registration linkage versus actual trials and participants.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Original references, registration and links to the same cohort, analyses, visits and outcomes. Totals of unique trials and participants remain unrecorded. Only material requests and research needs are recorded; no retrieval or research is performed in this work."
    },
    {
      "item_id": "N25",
      "question_type": "Evidence condition",
      "question": "Is there separate independent confirmation?",
      "needed": "Distinguish a single manufacturer trial from independent replication",
      "role": "Supplementary",
      "role_reason": "This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Distinguish a single manufacturer trial from independent replication.",
      "application_exception": "Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Distinguish a single manufacturer trial from independent replication.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Confirmatory evidence with question-specific prespecified plans, separate populations and controls, direct endpoints and durations, effects and CIs, and funding or author relationships. No new search or independence verdict. Only material requests and research needs are recorded; no retrieval or research is performed in this work."
    },
    {
      "item_id": "N26",
      "question_type": "Evidence condition",
      "question": "Are subclaim grades distinguished from original parent scores and axes?",
      "needed": "Subclaim grade, note and absences versus parent D30",
      "role": "Required",
      "role_reason": "This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Subclaim grade, note and absences versus parent D30.",
      "application_exception": "Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Subclaim grade, note and absences versus parent D30.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Review of subclaim and parent boundaries and actual correction records. No new score or grade, or official RoB2 or GRADE certification. Only material requests and research needs are recorded; no retrieval or research is performed in this work."
    },
    {
      "item_id": "N27",
      "question_type": "Evidence condition",
      "question": "Are both languages and absent structured fields preserved?",
      "needed": "Korean and English originals and absent separate classification fields",
      "role": "Required",
      "role_reason": "This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Korean and English originals and absent separate classification fields.",
      "application_exception": "Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Korean and English originals and absent separate classification fields.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Review material for language-specific terminology, endpoints, visits, original statements and absences. Application-condition descriptions are distinguished from the preserved original record. Only material requests and research needs are recorded; no retrieval or research is performed in this work."
    },
    {
      "item_id": "N28",
      "question_type": "Evidence condition",
      "question": "Are the reference date, corrections and historical cross-checking separated from production?",
      "needed": "Original 2026-08-26 reference date and empty corrections",
      "role": "Required",
      "role_reason": "This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Original 2026-08-26 reference date and empty corrections.",
      "application_exception": "Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Original 2026-08-26 reference date and empty corrections.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: When actual new corrections or material arise, retain the original text and separate events, conditions, observations and verdict decisions for updates. Historical records are not treated as new quality review. Only material requests and research needs are recorded; no retrieval or research is performed in this work."
    },
    {
      "item_id": "N29",
      "question_type": "Evidence condition",
      "question": "Which direct material would fill the selected gaps?",
      "needed": "Prespecified questions, direct effects, CIs, plans and follow-up",
      "role": "Supplementary",
      "role_reason": "This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Prespecified questions, direct effects, CIs, plans and follow-up.",
      "application_exception": "Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Prespecified questions, direct effects, CIs, plans and follow-up.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Question-specific prespecified direct effects and CIs, denominators, missingness, measurement, effects of interest, clinical thresholds, multiplicity, separate confirmation, longer-term clinical outcomes and harms. Only material needs are recorded; no research or retrieval is performed. Only material requests and research needs are recorded; no retrieval or research is performed in this work."
    },
    {
      "item_id": "N30",
      "question_type": "Evidence condition",
      "question": "Are production, existing content review and practical instructions separated?",
      "needed": "Production request, historical candidate record and responsibility for existing content review",
      "role": "Supplementary",
      "role_reason": "This condition links the evidence need with the selected question, actual population, intervention and control, total score and subscales, hierarchy and effect of interest, denominators and follow-up, reports and harms: Production request, historical candidate record and responsibility for existing content review.",
      "application_exception": "Distinguish the primary total-score null finding, group-specific before-and-after values, baseline-adjusted P and d, gaps in CIs and clinical thresholds, subscale signals, multiplicity, baseline cognition, population, intervention, control, exposure, duration, ITT, withdrawal, denominators and harms. Only original numbers are retained. No new calculations, effects, CIs, hypothetical quantities, rejudging, grades, independence certification, consumption advice for MKP, milk or products, cognition or dementia care, or treatment-replacement instructions are produced.",
      "criterion": "Show source material and scope for the following evidence need, including the selected-subclaim and parent boundary, reports and endpoints, effect of interest, denominators and external reading scope: Production request, historical candidate record and responsibility for existing content review.",
      "basis": "Existing C/E/H distinctions concerning questions, populations, interventions, comparisons, reports and trials, outcomes and denominators, and harms are referenced for production.",
      "condition_origin": "Conditions for presenting a preserved existing subclaim; these are not preregistration, use of an official tool or completed content review.",
      "proposed_research": "Material needed: Existing content review and subsequent actual material and correction records. The original production performed no comparison of clinical source material, external reading, new calculations, grade changes or advice on MKP, milk or products, cognition or dementia care, or treatment replacement. Only material requests and research needs are recorded; no retrieval or research is performed in this work."
    }
  ]
}