# DDMP lactic-acid-bacteria beverage × Moisture change at weeks 4 and 8

Verdict 2979 · Evidence Check

Stored-material review date: Not recorded  
Original evidence cut-off: 2026-08-26  
Review-criteria version: 1.0  
Public page/material preparation date: 2026-10-14

Clinical papers were not read directly; existing review summaries were checked. No new clinical-literature search was performed. Unverified does not mean that research is absent or that there is no effect.

## Assessment scope

- Population: 220 healthy Japanese adults with dry skin were randomized, and 213 protocol-compliant participants were analyzed. Group- and visit-specific denominators, withdrawals and exclusions, eligibility, measurement sites and conditions are unverified.
- Ingredient, formulation and route: The study formulation was a 65 mL lactic-acid-bacteria beverage containing 2.2 mg DDMP. Its full ingredients, strains and viability, product and batch identity, and manufacturing specifications are unverified. The findings are not transferred to general probiotics, other beverages or separate DDMP formulations.
- Dose: Only the original study identity of 2.2 mg DDMP in a 65 mL beverage and 12-week follow-up is retained. Actual daily frequency, cumulative exposure and adherence are unverified. No new consumption or care instructions or conversions are produced.
- Comparator: An otherwise identical lactic-acid-bacteria beverage without DDMP. The original description of a double-blind randomized parallel comparison is retained. Ingredient and sensory matching, allocation and blinding procedures, and concurrent skin care are unverified.
- Measured outcome: Intermediate changes from baseline were +4.28 versus −2.09 at week 4 (P<0.001) and +8.47 versus +5.17 at week 8 (P=0.002). These are distinguished from final week-12 absolute values of 29.7±7.67 versus 29.7±6.19 a.u. (P=0.985) and changes of +8.05±6.85 versus +7.92±5.97 (P=0.877). The whole-time mixed-model P<0.001 concerns a trajectory difference, not a benefit at week 12. No new differences, CIs, effects or grades are calculated.
- Duration: Intermediate changes at weeks 4 and 8 and the prespecified final week-12 primary endpoint. Persistence beyond 12 weeks, other skin or clinical outcomes, and effects in other populations or products are unverified.
- Questions outside this scope: Calculating new between-group differences, ratios, CIs or response rates from +4.28 versus −2.09 at week 4 or +8.47 versus +5.17 at week 8; Recasting positive intermediate visits or a whole-time mixed-model P<0.001 as prespecified final week-12 efficacy or sustained benefit; Combining final absolute values with changes from baseline, skin sites or measurement conditions, or visit-specific denominators; Treating P=0.985 or P=0.877 as proof of a zero effect, equivalence or exclusion of meaningful benefit; Adding the 220 randomized and 213 analyzed participants, groups, visits, skin sites, references or related sheets as new independent trials or participants; Transferring the DDMP-versus-no-DDMP comparison within the same beverage to all DDMP formulations, probiotics or general beverages, or other skin or clinical effects; Inheriting parent values/axes and historical cross-checks as subclaim scores, current review or original-source reading; New calculations, hypothetical values, effects/CIs, grades, independence certification, drink/extract/product intake, skin/sleep management or treatment-substitution instructions

## Checklist items

### N01 · Selected intermediate-visit question and original grade

Verification status: Partly verified  
Reading scope: Summary read; external material unread

- Current findings: The selected subclaim is “Moisture change at weeks 4 and 8”, grade C, recording positive intermediate findings and loss of the difference by final week 12. Subclaim score, status and axes are absent. Parent grade D with 28 points is retained as the final week-12 verdict context.
- Why unverified: Only the relevant information in the preserved summary is recorded. Detailed source material has not been read, and review of the existing content is incomplete. Subclaim score, status and axes are absent and are not filled with parent values. Review of the existing content is incomplete.
- Reason for missing information: Subclaim score, status and axes are absent and are not filled with parent values.
- Required materials and conditions: Distinction between the original wording and grade for weeks 4 and 8 and the parent final-visit verdict
- Materials to obtain first: Original selected question and parent verdict, and user corrections
- Further research: A preserved proposal for follow-up research that distinguishes the original question's scope at each visit. No new investigation, calculation or trial was performed.
- Conditions for verification: Relevant source data and analysis details for distinction between the original wording and grade for weeks 4 and 8 and the parent final-visit verdict must be provided, with unverified points identified. Preserved wording is linked here; review of the existing content is incomplete.
- Why this condition is needed: This item distinguishes distinction between the original wording and grade for weeks 4 and 8 and the parent final-visit verdict to connect the evidence needed for the selected question with the evidence currently available.
- Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
- Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
- Referenced methods: M03 §3.1, §3.2.1–3.2.4 question-clarification principles; detailed separation rules are custom design; M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptation is custom design; M04 §4.5, §4.6.3; limits on current material conversion reflect the review scope and custom design
- Related sources: S01

### N02 · Population, recruitment and skin condition

Verification status: Partly verified  
Reading scope: Summary read; external material unread

- Current findings: 220 healthy Japanese adults with dry skin were randomized. The original summary does not record intermediate-visit effects in other age groups or skin-disease populations.
- Why unverified: Only the relevant information in the preserved summary is recorded. Detailed source material has not been read, and review of the existing content is incomplete. Detailed eligibility, age distribution, sex, diagnostic or measurement criteria for skin condition, and baseline environmental conditions are unverified. Review of the existing content is incomplete.
- Reason for missing information: Detailed eligibility, age distribution, sex, diagnostic or measurement criteria for skin condition, and baseline environmental conditions are unverified.
- Required materials and conditions: Actual participants' ages, eligibility, dry-skin definition and recruitment conditions
- Materials to obtain first: Eligibility, recruitment and baseline-characteristic tables
- Further research: A preserved proposal for follow-up research that compares the same formulation with explicitly defined population criteria. No new investigation, calculation or trial was performed.
- Conditions for verification: Relevant source data and analysis details for actual participants' ages, eligibility, dry-skin definition and recruitment conditions must be provided, with unverified points identified. Preserved wording is linked here; review of the existing content is incomplete.
- Why this condition is needed: This item distinguishes actual participants' ages, eligibility, dry-skin definition and recruitment conditions to connect the evidence needed for the selected question with the evidence currently available.
- Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
- Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
- Referenced methods: M03 §3.2.1; Detailed population conditions are Chamgap design; M03 §3.2.1–3.2.4; Dose, duration and effect-modifier details are Chamgap design
- Related sources: S01

### N03 · Identity of the study beverage

Verification status: Partly verified  
Reading scope: Summary read; external material unread

- Current findings: The intervention was a 65 mL lactic-acid-bacteria beverage containing 2.2 mg DDMP. This study exposure is not recast as evidence for general lactic-acid bacteria or probiotics, other beverages, or all DDMP formulations.
- Why unverified: Only the relevant information in the preserved summary is recorded. Detailed source material has not been read, and review of the existing content is incomplete. Strains, viability, full ingredients and manufacturing specifications, and correspondence across formulations are unverified. Review of the existing content is incomplete.
- Reason for missing information: Strains, viability, full ingredients and manufacturing specifications, and correspondence across formulations are unverified.
- Required materials and conditions: DDMP content, beverage formulation, other ingredients and product identity
- Materials to obtain first: Ingredient, manufacturing and identity records for the study and control beverages
- Further research: A preserved proposal for follow-up research that distinguishes formulation effects from attribution to individual ingredients. No new investigation, calculation or trial was performed.
- Conditions for verification: Relevant source data and analysis details for DDMP content, beverage formulation, other ingredients and product identity must be provided, with unverified points identified. Preserved wording is linked here; review of the existing content is incomplete.
- Why this condition is needed: This item distinguishes DDMP content, beverage formulation, other ingredients and product identity to connect the evidence needed for the selected question with the evidence currently available.
- Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
- Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
- Referenced methods: M03 §3.2.2–3.2.3; Reverse-direction labels and assessment adaptation are Chamgap design; M03 §3.2.3 and M08 §8.2.2–8.2.3; Chamgap application
- Related sources: S01

### N04 · Identical-beverage control without DDMP

Verification status: Partly verified  
Reading scope: Summary read; external material unread

- Current findings: The original record describes a control beverage that lacked only DDMP and was otherwise the same lactic-acid-bacteria beverage. This compares the presence and absence of DDMP within that beverage, not consumption versus non-consumption of a general beverage.
- Why unverified: Only the relevant information in the preserved summary is recorded. Detailed source material has not been read, and review of the existing content is incomplete. Manufacturing and ingredient matching, taste and appearance, and participants' ability to distinguish the beverages are unverified. Review of the existing content is incomplete.
- Reason for missing information: Manufacturing and ingredient matching, taste and appearance, and participants' ability to distinguish the beverages are unverified.
- Required materials and conditions: Actual intervention-control differences and ingredient or contact matching
- Materials to obtain first: Control ingredient, sensory and manufacturing matching records
- Further research: A preserved proposal for follow-up research that clearly specifies the differences from the control. No new investigation, calculation or trial was performed.
- Conditions for verification: Relevant source data and analysis details for actual intervention-control differences and ingredient or contact matching must be provided, with unverified points identified. Preserved wording is linked here; review of the existing content is incomplete.
- Why this condition is needed: This item distinguishes actual intervention-control differences and ingredient or contact matching to connect the evidence needed for the selected question with the evidence currently available.
- Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
- Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
- Referenced methods: M03 §3.2.2–3.2.3; reverse-direction labels and testing adaptations are internally designed; M08 Table 8.2.a, M03 §3.2.4; internal application
- Related sources: S01

### N05 · Random allocation and concealment

Verification status: Partly verified  
Reading scope: Summary read; external material unread

- Current findings: S01 is described as a double-blind randomized identical-beverage placebo-controlled parallel trial. The design label is not treated as verification of the entire allocation procedure.
- Why unverified: Only the relevant information in the preserved summary is recorded. Detailed source material has not been read, and review of the existing content is incomplete. Sequence generation, concealment, who implemented allocation, and group-specific baseline balance are unverified. Review of the existing content is incomplete.
- Reason for missing information: Sequence generation, concealment, who implemented allocation, and group-specific baseline balance are unverified.
- Required materials and conditions: Sequence generation, allocation concealment and implementation
- Materials to obtain first: Randomization, allocation-concealment and baseline tables
- Further research: Proposed follow-up trial disclosing allocation procedures; no new investigation, calculation or trial was performed in this production.
- Conditions for verification: Relevant source data and analysis details for sequence generation, allocation concealment and implementation must be provided, with unverified points identified. Preserved wording is linked here; review of the existing content is incomplete.
- Why this condition is needed: This item distinguishes sequence generation, allocation concealment and implementation to connect the evidence needed for the selected question with the evidence currently available.
- Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
- Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
- Referenced methods: M08 §8.1–8.2.3; Internal application; M03 §3.2.1; Detailed population conditions are internally designed
- Related sources: S01

### N06 · Blinding and assessors

Verification status: Partly verified  
Reading scope: Summary read; external material unread

- Current findings: The original double-blind label is retained. It is not stated that blinding of stratum-corneum moisture assessors and analysts, or its maintenance, was fully verified.
- Why unverified: Only the relevant information in the preserved summary is recorded. Detailed source material has not been read, and review of the existing content is incomplete. Who was blinded, blinding success, unblinding timing and assessment conditions are unverified. Review of the existing content is incomplete.
- Reason for missing information: Who was blinded, blinding success, unblinding timing and assessment conditions are unverified.
- Required materials and conditions: Actual blinding of participants, assessors and analysts and its maintenance
- Materials to obtain first: Blinding procedures and assessor-role records
- Further research: A preserved proposal for follow-up research that specifies assessor blinding and measurement conditions. No new investigation, calculation or trial was performed.
- Conditions for verification: Relevant source data and analysis details for actual blinding of participants, assessors and analysts and its maintenance must be provided, with unverified points identified. Preserved wording is linked here; review of the existing content is incomplete.
- Why this condition is needed: This item distinguishes actual blinding of participants, assessors and analysts and its maintenance to connect the evidence needed for the selected question with the evidence currently available.
- Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
- Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
- Referenced methods: M08 Table 8.2.a, M03 §3.2.4; own application; M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific result adaptation is our own design
- Related sources: S01

### N07 · 12-week exposure and adherence

Verification status: Partly verified  
Reading scope: Summary read; external material unread

- Current findings: The source records 12-week follow-up and analysis of protocol-compliant participants. The 2.2 mg/65 mL specification is retained only as the beverage identity; no new consumption instructions are produced.
- Why unverified: Only the relevant information in the preserved summary is recorded. Detailed source material has not been read, and review of the existing content is incomplete. Daily frequency, actual cumulative exposure, adherence and reasons for protocol violations are unverified. Review of the existing content is incomplete.
- Reason for missing information: Daily frequency, actual cumulative exposure, adherence and reasons for protocol violations are unverified.
- Required materials and conditions: Study exposure, consumption records, group-specific adherence and withdrawal criteria
- Materials to obtain first: Exposure, adherence and protocol-compliance criteria
- Further research: A preserved proposal for follow-up research that distinguishes exposure from the analysis population. No new investigation, calculation or trial was performed.
- Conditions for verification: Relevant source data and analysis details for study exposure, consumption records, group-specific adherence and withdrawal criteria must be provided, with unverified points identified. Preserved wording is linked here; review of the existing content is incomplete.
- Why this condition is needed: This item distinguishes study exposure, consumption records, group-specific adherence and withdrawal criteria to connect the evidence needed for the selected question with the evidence currently available.
- Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
- Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
- Referenced methods: M03 §3.2.3, M08 §8.2.2–8.2.3; our own application; M08 §8.2.2, M15 §15.3.1; our own application
- Related sources: S01

### N08 · Skin sites and measurement environment

Verification status: Unverified  
Reading scope: Summary read; external material unread

- Current findings: The original endpoint is stratum-corneum moisture. The summary is not supplemented with an unsupported assertion that skin sites or measurement conditions remained identical.
- Why unverified: The information currently needed is unverified in the preserved summary. Measurement sites, left-right or repeated measurements, instruments, temperature and humidity, premeasurement conditions and assessors are unverified. Review of the existing content is incomplete.
- Reason for missing information: Measurement sites, left-right or repeated measurements, instruments, temperature and humidity, premeasurement conditions and assessors are unverified.
- Required materials and conditions: Skin sites, instruments, temperature and humidity, acclimatization and measurement conditions at each visit
- Materials to obtain first: Measurement manuals and site- or environment-specific results
- Further research: A preserved proposal for follow-up research that specifies measurement conditions at each visit. No new investigation, calculation or trial was performed.
- Conditions for verification: Relevant source data and analysis details for skin sites, instruments, temperature and humidity, acclimatization and measurement conditions at each visit must be provided, with unverified points identified. Preserved wording is linked here; review of the existing content is incomplete.
- Why this condition is needed: This item distinguishes skin sites, instruments, temperature and humidity, acclimatization and measurement conditions at each visit to connect the evidence needed for the selected question with the evidence currently available.
- Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
- Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
- Referenced methods: M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are our own design; M08 Table 8.2.a, M03 §3.2.4; our own application
- Related sources: S01

### N09 · Baseline, units and definition of change

Verification status: Partly verified  
Reading scope: Summary read; external material unread

- Current findings: Final week-12 values are preserved in a.u., while intermediate visits are described as changes from baseline. Absolute values and changes are not combined as the same outcome.
- Why unverified: Only the relevant information in the preserved summary is recorded. Detailed source material has not been read, and review of the existing content is incomplete. Group-specific baseline values, the exact change calculation, and intermediate absolute values and standard deviations are unverified. Review of the existing content is incomplete.
- Reason for missing information: Group-specific baseline values, the exact change calculation, and intermediate absolute values and standard deviations are unverified.
- Required materials and conditions: Units and calculation definitions for absolute moisture values and changes from baseline
- Materials to obtain first: Baseline and visit-specific absolute-value or change tables and analysis definitions
- Further research: A preserved proposal for follow-up research that reports absolute values and change estimates separately. No new investigation, calculation or trial was performed.
- Conditions for verification: Relevant source data and analysis details for units and calculation definitions for absolute moisture values and changes from baseline must be provided, with unverified points identified. Preserved wording is linked here; review of the existing content is incomplete.
- Why this condition is needed: This item distinguishes units and calculation definitions for absolute moisture values and changes from baseline to connect the evidence needed for the selected question with the evidence currently available.
- Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
- Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
- Referenced methods: M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are our own design; M08 §8.2.2, M15 §15.3.1; our own application
- Related sources: S01

### N10 · Moisture change at week 4

Verification status: Partly verified  
Reading scope: Summary read; external material unread

- Current findings: The manuscript records changes from baseline at week 4 of +4.28 versus −2.09, P<0.001. No new between-group difference, ratio or CI is calculated, and this is not recast as a sustained 12-week effect.
- Why unverified: Only the relevant information in the preserved summary is recorded. Detailed source material has not been read, and review of the existing content is incomplete. Week-4 absolute values, SDs or SEs, 95% CI, visit-specific analysis denominators and the exact model are unverified. Review of the existing content is incomplete.
- Reason for missing information: Week-4 absolute values, SDs or SEs, 95% CI, visit-specific analysis denominators and the exact model are unverified.
- Required materials and conditions: Week-4 changes by group, comparison and uncertainty
- Materials to obtain first: Week-4 results, denominators, analysis and CI records
- Further research: A preserved proposal for follow-up research that distinguishes week-4 changes from final effects. No new investigation, calculation or trial was performed.
- Conditions for verification: Relevant source data and analysis details for week-4 changes by group, comparison and uncertainty must be provided, with unverified points identified. Preserved wording is linked here; review of the existing content is incomplete.
- Why this condition is needed: This item distinguishes week-4 changes by group, comparison and uncertainty to connect the evidence needed for the selected question with the evidence currently available.
- Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
- Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
- Referenced methods: M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptation is internally designed; M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; design-specific adaptation is internally designed; M15 §15.3.1–15.3.3; internal application
- Related sources: S01

### N11 · Moisture change at week 8

Verification status: Partly verified  
Reading scope: Summary read; external material unread

- Current findings: The manuscript records changes from baseline at week 8 of +8.47 versus +5.17, P=0.002. No new difference, CI or individual improvement rate is produced.
- Why unverified: Only the relevant information in the preserved summary is recorded. Detailed source material has not been read, and review of the existing content is incomplete. Week-8 absolute values, SDs or SEs, 95% CI, visit-specific denominators and the exact analysis specification are unverified. Review of the existing content is incomplete.
- Reason for missing information: Week-8 absolute values, SDs or SEs, 95% CI, visit-specific denominators and the exact analysis specification are unverified.
- Required materials and conditions: Week-8 changes by group, comparison and uncertainty
- Materials to obtain first: Week-8 results, denominators, analysis and CI records
- Further research: A preserved proposal for follow-up research that distinguishes replication of intermediate changes from persistence at the final visit. No new investigation, calculation or trial was performed.
- Conditions for verification: Relevant source data and analysis details for week-8 changes by group, comparison and uncertainty must be provided, with unverified points identified. Preserved wording is linked here; review of the existing content is incomplete.
- Why this condition is needed: This item distinguishes week-8 changes by group, comparison and uncertainty to connect the evidence needed for the selected question with the evidence currently available.
- Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
- Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
- Referenced methods: M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptation is internally designed; M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; design-specific adaptation is internally designed; M15 §15.3.1–15.3.3; internal application
- Related sources: S01

### N12 · Final week-12 absolute moisture values

Verification status: Partly verified  
Reading scope: Summary read; external material unread

- Current findings: Week-12 values were 29.7±7.67 versus 29.7±6.19 a.u., P=0.985. The final null finding is retained alongside the positive intermediate findings; P is not used as proof of an exactly zero effect or equivalence.
- Why unverified: Only the relevant information in the preserved summary is recorded. Detailed source material has not been read, and review of the existing content is incomplete. The 95% CI and the range needed to exclude a clinically meaningful benefit are unverified. Review of the existing content is incomplete.
- Reason for missing information: The 95% CI and the range needed to exclude a clinically meaningful benefit are unverified.
- Required materials and conditions: Absolute values, units and P for the prespecified final primary endpoint
- Materials to obtain first: Final absolute-value estimates, CIs and analysis tables
- Further research: A preserved proposal for follow-up research that adequately reports the final-visit effect and uncertainty. No new investigation, calculation or trial was performed.
- Conditions for verification: Relevant source data and analysis details for absolute values, units and P for the prespecified final primary endpoint must be provided, with unverified points identified. Preserved wording is linked here; review of the existing content is incomplete.
- Why this condition is needed: This item distinguishes absolute values, units and P for the prespecified final primary endpoint to connect the evidence needed for the selected question with the evidence currently available.
- Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
- Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
- Referenced methods: M03 §3.2.4 and M15 §15.3.1–15.3.3: question-specific outcome adaptation is in-house; M04 §4.6.3 and M15 §15.3.1–15.3.3: status separation is in-house; M15 §15.3.1–15.3.3: in-house application.
- Related sources: S01

### N13 · Final week-12 change values

Verification status: Partly verified  
Reading scope: Summary read; external material unread

- Current findings: Week-12 changes were +8.05±6.85 versus +7.92±5.97, P=0.877. These estimates are distinguished from final absolute values with P=0.985.
- Why unverified: Only the relevant information in the preserved summary is recorded. Detailed source material has not been read, and review of the existing content is incomplete. The change estimate's 95% CI and the exact between-group effect and clinical importance are unverified. Review of the existing content is incomplete.
- Reason for missing information: The change estimate's 95% CI and the exact between-group effect and clinical importance are unverified.
- Required materials and conditions: Distinction between final changes from baseline and absolute values
- Materials to obtain first: Baseline adjustment, change estimates and CIs
- Further research: A preserved proposal for follow-up research that reports changes and final absolute values separately. No new investigation, calculation or trial was performed.
- Conditions for verification: Relevant source data and analysis details for distinction between final changes from baseline and absolute values must be provided, with unverified points identified. Preserved wording is linked here; review of the existing content is incomplete.
- Why this condition is needed: This item distinguishes distinction between final changes from baseline and absolute values to connect the evidence needed for the selected question with the evidence currently available.
- Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
- Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
- Referenced methods: M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptation is internally designed; M04 §4.6.3, M15 §15.3.1–15.3.3; status separation is internally designed; M08 §8.2.2, M15 §15.3.1; internal application; M15 §15.3.1–15.3.3; internal application
- Related sources: S01

### N14 · Whole-time mixed model

Verification status: Partly verified  
Reading scope: Summary read; external material unread

- Current findings: The original explanation states that the whole-time mixed-model P<0.001 concerns differing patterns across visits. It is not recast as a positive week-12 effect or a sustained benefit at every visit.
- Why unverified: Only the relevant information in the preserved summary is recorded. Detailed source material has not been read, and review of the existing content is incomplete. Model terms, repeated-measure covariance, interaction or main effects, prespecified plans and individual contrasts are unverified. Review of the existing content is incomplete.
- Reason for missing information: Model terms, repeated-measure covariance, interaction or main effects, prespecified plans and individual contrasts are unverified.
- Required materials and conditions: Specification of the whole-trajectory test and individual-visit effects
- Materials to obtain first: Mixed-model and repeated-measure plans and results, and visit-specific contrasts
- Further research: A preserved proposal for follow-up research that distinguishes the whole trajectory from final and intermediate contrasts. No new investigation, calculation or trial was performed.
- Conditions for verification: Relevant source data and analysis details for specification of the whole-trajectory test and individual-visit effects must be provided, with unverified points identified. Preserved wording is linked here; review of the existing content is incomplete.
- Why this condition is needed: This item distinguishes specification of the whole-trajectory test and individual-visit effects to connect the evidence needed for the selected question with the evidence currently available.
- Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
- Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
- Referenced methods: M08 §8.2.2, M15 §15.3.1; internal application; M08 Table 8.2.a, M04 §4.6.3; internal application; M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptation is internally designed
- Related sources: S01

### N15 · Primary-endpoint and intermediate-result hierarchy

Verification status: Partly verified  
Reading scope: Summary read; external material unread

- Current findings: The prespecified primary endpoint is stratum-corneum moisture at final week 12. Positive weeks 4 and 8 are recorded but are not promoted to the primary endpoint or used to replace the final conclusion.
- Why unverified: Only the relevant information in the preserved summary is recorded. Detailed source material has not been read, and review of the existing content is incomplete. Prespecification of week-4 and week-8 analyses, secondary hierarchy, testing order and analysis changes are unverified. Review of the existing content is incomplete.
- Reason for missing information: Prespecification of week-4 and week-8 analyses, secondary hierarchy, testing order and analysis changes are unverified.
- Required materials and conditions: Hierarchy of the prespecified final week-12 primary endpoint and intermediate visits
- Materials to obtain first: Visit and hierarchy records in the registration, protocol and SAP
- Further research: A preserved proposal for follow-up research that explicitly specifies the final and intermediate endpoint hierarchy. No new investigation, calculation or trial was performed.
- Conditions for verification: Relevant source data and analysis details for hierarchy of the prespecified final week-12 primary endpoint and intermediate visits must be provided, with unverified points identified. Preserved wording is linked here; review of the existing content is incomplete.
- Why this condition is needed: This item distinguishes hierarchy of the prespecified final week-12 primary endpoint and intermediate visits to connect the evidence needed for the selected question with the evidence currently available.
- Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
- Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
- Referenced methods: M08 Table 8.2.a, M04 §4.6.3; Chamgap application; M04 §4.6.3, M15 §15.3.1–15.3.3; separation of statuses is Chamgap's own design
- Related sources: S01

### N16 · Unreported CIs and meaningful benefit

Verification status: Partly verified  
Reading scope: Summary read; external material unread

- Current findings: The manuscript records that the paper reported no 95% CI and that a meaningful benefit therefore cannot be excluded. No new CI, equivalence margin or response threshold is produced.
- Why unverified: Only the relevant information in the preserved summary is recorded. Detailed source material has not been read, and review of the existing content is incomplete. Visit-specific CIs, prespecified importance thresholds and effect precision are unverified. Review of the existing content is incomplete.
- Reason for missing information: Visit-specific CIs, prespecified importance thresholds and effect precision are unverified.
- Required materials and conditions: Exact effects, CIs and importance thresholds
- Materials to obtain first: Original result tables, CIs and prespecified importance thresholds
- Further research: A preserved proposal for follow-up research that specifies CIs and importance thresholds. No new investigation, calculation or trial was performed.
- Conditions for verification: Relevant source data and analysis details for exact effects, CIs and importance thresholds must be provided, with unverified points identified. Preserved wording is linked here; review of the existing content is incomplete.
- Why this condition is needed: This item distinguishes exact effects, CIs and importance thresholds to connect the evidence needed for the selected question with the evidence currently available.
- Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
- Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
- Referenced methods: M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; design-specific adaptation is internally designed; M15 §15.3.1–15.3.3; internal application
- Related sources: S01

### N17 · 220 randomized and 213 in PPS

Verification status: Partly verified  
Reading scope: Summary read; external material unread

- Current findings: The original counts of 220 randomized and 213 protocol-compliant participants analyzed are retained. The counts are not added together or treated as confirmation of every visit denominator or a complete ITT analysis.
- Why unverified: Only the relevant information in the preserved summary is recorded. Detailed source material has not been read, and review of the existing content is incomplete. Group-specific PPS, valid visit-specific denominators, FAS or ITT results and exclusion criteria are unverified. Review of the existing content is incomplete.
- Reason for missing information: Group-specific PPS, valid visit-specific denominators, FAS or ITT results and exclusion criteria are unverified.
- Required materials and conditions: Distinction between randomized and analyzed populations and group- or visit-specific denominators
- Materials to obtain first: Participant flow, analysis-population and visit-specific denominator tables
- Further research: A preserved proposal for follow-up research that reports the full randomized population and PPS results together. No new investigation, calculation or trial was performed.
- Conditions for verification: Relevant source data and analysis details for distinction between randomized and analyzed populations and group- or visit-specific denominators must be provided, with unverified points identified. Preserved wording is linked here; review of the existing content is incomplete.
- Why this condition is needed: This item distinguishes distinction between randomized and analyzed populations and group- or visit-specific denominators to connect the evidence needed for the selected question with the evidence currently available.
- Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
- Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
- Referenced methods: M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; design-specific adaptation is internally designed; M08 §8.2.2, M15 §15.3.1; internal application; M08 §8.1–8.2.3; internal application
- Related sources: S01

### N18 · Withdrawal, missing data and analysis exclusions

Verification status: Unverified  
Reading scope: Summary read; external material unread

- Current findings: The manuscript records that the primary analysis used 213 protocol-compliant participants rather than all 220 randomized. No new exclusion count is calculated or missing-data impact established.
- Why unverified: The information currently needed is unverified in the preserved summary. Reasons, timing and group patterns of missingness, withdrawal or exclusion, and adjustment or sensitivity results are unverified. Review of the existing content is incomplete.
- Reason for missing information: Reasons, timing and group patterns of missingness, withdrawal or exclusion, and adjustment or sensitivity results are unverified.
- Required materials and conditions: Reasons for withdrawal, missing data, group-specific effects and handling
- Materials to obtain first: Participant-flow diagrams, missing-data handling and sensitivity results
- Further research: A preserved proposal for follow-up research that distinguishes the effects of missingness and nonadherence. No new investigation, calculation or trial was performed.
- Conditions for verification: Relevant source data and analysis details for reasons for withdrawal, missing data, group-specific effects and handling must be provided, with unverified points identified. Preserved wording is linked here; review of the existing content is incomplete.
- Why this condition is needed: This item distinguishes reasons for withdrawal, missing data, group-specific effects and handling to connect the evidence needed for the selected question with the evidence currently available.
- Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
- Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
- Referenced methods: M08 Table 8.2.a, M15 §15.3 and M19 §19.1.2–19.2.4; Design-specific adaptation is Chamgap design; M08 §8.2.2 and M15 §15.3.1; Chamgap application
- Related sources: S01

### N19 · Within-group change and between-group comparison

Verification status: Partly verified  
Reading scope: Summary read; external material unread

- Current findings: Group-specific changes at weeks 4, 8 and 12 and their P values are retained exactly as in the preserved summary. Within-group changes alone are not used to create a placebo-relative difference or a new numerical effect.
- Why unverified: Only the relevant information in the preserved summary is recorded. Detailed source material has not been read, and review of the existing content is incomplete. Exact between-group contrasts, baseline adjustment, model-specific estimates and whether within-group tests were used are unverified. Review of the existing content is incomplete.
- Reason for missing information: Exact between-group contrasts, baseline adjustment, model-specific estimates and whether within-group tests were used are unverified.
- Required materials and conditions: Group correspondence and within- or between-group change estimands
- Materials to obtain first: Original result tables, group correspondence and contrast definitions
- Further research: A preserved proposal for follow-up research that clearly reports within- and between-group estimands. No new investigation, calculation or trial was performed.
- Conditions for verification: Relevant source data and analysis details for group correspondence and within- or between-group change estimands must be provided, with unverified points identified. Preserved wording is linked here; review of the existing content is incomplete.
- Why this condition is needed: This item distinguishes group correspondence and within- or between-group change estimands to connect the evidence needed for the selected question with the evidence currently available.
- Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
- Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
- Referenced methods: M08 §8.2.2, M15 §15.3.1; Chamgap's own application; M15 §15.3.1–15.3.3; Chamgap's own application; M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are Chamgap's own design
- Related sources: S01

### N20 · UMIN identifier and reading of prespecified plans

Verification status: Partly verified  
Reading scope: Summary read; external material unread

- Current findings: The preserved registration identifier is UMIN000052867. The UMIN number is retained in its original form, and no claim is made that the external registration has been read.
- Why unverified: Only the relevant information in the preserved summary is recorded. Detailed source material has not been read, and review of the existing content is incomplete. Registration identity and date, prerecruitment plans, visit hierarchy, changes, and full protocol or SAP text have not been read. Review of the existing content is incomplete.
- Reason for missing information: Registration identity and date, prerecruitment plans, visit hierarchy, changes, and full protocol or SAP text have not been read.
- Required materials and conditions: Actual verification scope for registration, protocol, SAP and change history
- Materials to obtain first: UMIN registry history, protocol and SAP
- Further research: A preserved proposal for follow-up research that links prespecified plans with the analyses actually performed. No new investigation, calculation or trial was performed.
- Conditions for verification: Relevant source data and analysis details for actual verification scope for registration, protocol, SAP and change history must be provided, with unverified points identified. Preserved wording is linked here; review of the existing content is incomplete.
- Why this condition is needed: This item distinguishes actual verification scope for registration, protocol, SAP and change history to connect the evidence needed for the selected question with the evidence currently available.
- Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
- Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
- Referenced methods: Data collection and selection principles in M04 §4.5–4.6; separation of access from reading and the hyperlink contract are internally designed; M08 Table 8.2.a, M04 §4.6.3; internal application; M04 §4.5, §4.6.3; limits of this material conversion reflect the review scope and internal design
- Related sources: S01

### N21 · Multiple visits, sites and tests

Verification status: Partly verified  
Reading scope: Summary read; external material unread

- Current findings: Positive weeks 4 and 8, the final week-12 null finding and the whole-time model are different analyses of the same trial. Multiple P values are not counted as independent replications or overall success.
- Why unverified: Only the relevant information in the preserved summary is recorded. Detailed source material has not been read, and review of the existing content is incomplete. The total number of tests, site or visit selection, adjustments and prespecified analysis order are unverified. Review of the existing content is incomplete.
- Reason for missing information: The total number of tests, site or visit selection, adjustments and prespecified analysis order are unverified.
- Required materials and conditions: Multiplicity specification for intermediate visits, skin sites and analyses
- Materials to obtain first: Multiplicity plans and complete result tables
- Further research: A preserved proposal for follow-up research that distinguishes multiple-visit findings from the final primary endpoint. No new investigation, calculation or trial was performed.
- Conditions for verification: Relevant source data and analysis details for multiplicity specification for intermediate visits, skin sites and analyses must be provided, with unverified points identified. Preserved wording is linked here; review of the existing content is incomplete.
- Why this condition is needed: This item distinguishes multiplicity specification for intermediate visits, skin sites and analyses to connect the evidence needed for the selected question with the evidence currently available.
- Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
- Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
- Referenced methods: M08 Table 8.2.a, M04 §4.6.3; internal application; M04 §4.6.1–4.6.2 distinguishes studies from reports; cohort and outcome linkage is an internal application; M04 §4.6.3, M15 §15.3.1–15.3.3; status separation is internally designed
- Related sources: S01

### N22 · Concurrent skin care, season and lifestyle

Verification status: Unverified  
Reading scope: Summary read; external material unread

- Current findings: The source scope is an identical-beverage control and 12-week follow-up. It is not supplemented with a claim that other skin care, climate, diet or lifestyle conditions were completely identical.
- Why unverified: The information currently needed is unverified in the preserved summary. Concurrent moisturizing or care, lifestyle, season or environment, concomitant medication and analyses of differences are unverified. Review of the existing content is incomplete.
- Reason for missing information: Concurrent moisturizing or care, lifestyle, season or environment, concomitant medication and analyses of differences are unverified.
- Required materials and conditions: Group-specific concurrent exposures, lifestyle, seasonal conditions and moisturizer or other care records
- Materials to obtain first: Concurrent-exposure, environmental and lifestyle records and analyses
- Further research: A preserved proposal for follow-up research that explicitly specifies concurrent conditions. No new investigation, calculation or trial was performed.
- Conditions for verification: Relevant source data and analysis details for group-specific concurrent exposures, lifestyle, seasonal conditions and moisturizer or other care records must be provided, with unverified points identified. Preserved wording is linked here; review of the existing content is incomplete.
- Why this condition is needed: This item distinguishes group-specific concurrent exposures, lifestyle, seasonal conditions and moisturizer or other care records to connect the evidence needed for the selected question with the evidence currently available.
- Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
- Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
- Referenced methods: M03 §3.2.3, M08 §8.2.2–8.2.3; own application; M03 §3.2.2–3.2.3; reverse-direction labels and test adaptations are our own design
- Related sources: S01

### N23 · Provision of study and placebo beverages

Verification status: Partly verified  
Reading scope: Summary read; external material unread

- Current findings: The original record states that Nissin York supplied the study and placebo beverages. Product provision is not recast as absence of monetary funding or verification of an independent trial.
- Why unverified: Only the relevant information in the preserved summary is recorded. Detailed source material has not been read, and review of the existing content is incomplete. Provision agreements, support scope, product-quality or manufacturing records and influence on decisions are unverified. Review of the existing content is incomplete.
- Reason for missing information: Provision agreements, support scope, product-quality or manufacturing records and influence on decisions are unverified.
- Required materials and conditions: Manufacturer product support and scope of provision
- Materials to obtain first: Product-support and provision agreements or disclosures
- Further research: A proposed follow-up trial disclosing support roles; no new investigation, calculation or trial was performed.
- Conditions for verification: Relevant source data and analysis details for manufacturer product support and scope of provision must be provided, with unverified points identified. Preserved wording is linked here; review of the existing content is incomplete.
- Why this condition is needed: This item distinguishes manufacturer product support and scope of provision to connect the evidence needed for the selected question with the evidence currently available.
- Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
- Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
- Referenced methods: Chamgap's own conditions for independence and attribution. The official methodological sections used in this example do not validate every detail of these items.
- Related sources: S01

### N24 · Employee authors and contract organization

Verification status: Partly verified  
Reading scope: Summary read; external material unread

- Current findings: The manuscript's affiliations are retained: T.S., M.T. and S.S. at the Nissin York Development Research Institute, and M.M. at M&I Science. Affiliations alone do not verify all research roles or conflicts of interest.
- Why unverified: Only the relevant information in the preserved summary is recorded. Detailed source material has not been read, and review of the existing content is incomplete. Specific roles and independence in design, analysis, data management, writing and publication decisions are unverified. Review of the existing content is incomplete.
- Reason for missing information: Specific roles and independence in design, analysis, data management, writing and publication decisions are unverified.
- Required materials and conditions: Author affiliations and roles of the company and contract organization
- Materials to obtain first: Author contributions, affiliations, COI and contract records
- Further research: A preserved proposal for follow-up research that separately discloses company and contract-organization roles. No new investigation, calculation or trial was performed.
- Conditions for verification: Relevant source data and analysis details for author affiliations and roles of the company and contract organization must be provided, with unverified points identified. Preserved wording is linked here; review of the existing content is incomplete.
- Why this condition is needed: This item distinguishes author affiliations and roles of the company and contract organization to connect the evidence needed for the selected question with the evidence currently available.
- Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
- Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
- Referenced methods: Chamgap's own conditions for independence and attribution. The official methodological sections used in this example do not validate every detail of these items.
- Related sources: S01

### N25 · Public funding, writing and publication costs

Verification status: Partly verified  
Reading scope: Summary read; external material unread

- Current findings: The original summary states that separate public funding, medical-writing and publication costs were not reported. Nonreporting is not judged to establish an absence of support or all conflicts of interest.
- Why unverified: Only the relevant information in the preserved summary is recorded. Detailed source material has not been read, and review of the existing content is incomplete. Full original funding, medical-writing, publication-cost and other support or COI disclosures have not been read. Review of the existing content is incomplete.
- Reason for missing information: Full original funding, medical-writing, publication-cost and other support or COI disclosures have not been read.
- Required materials and conditions: Item-specific reporting of funding, writing and publication support
- Materials to obtain first: Funding, support, medical-writing, publication-cost and COI disclosures
- Further research: A preserved proposal for follow-up research that separately discloses each support category. No new investigation, calculation or trial was performed.
- Conditions for verification: Relevant source data and analysis details for item-specific reporting of funding, writing and publication support must be provided, with unverified points identified. Preserved wording is linked here; review of the existing content is incomplete.
- Why this condition is needed: This item distinguishes item-specific reporting of funding, writing and publication support to connect the evidence needed for the selected question with the evidence currently available.
- Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
- Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
- Referenced methods: Chamgap independence/attribution conditions. The referenced official method sections do not certify every detail of these items; Data collection/selection principles in M04 §4.5–4.6; Access/reading separation and hyperlink rules are Chamgap design
- Related sources: S01

### N26 · Same trial and intermediate or final results

Verification status: Partly verified  
Reading scope: Summary read; external material unread

- Current findings: Weeks 4, 8 and 12 in S01 Sato2025 concern one report and the same randomized-population and PPS context. Visits, skin sites, references and related sheets are not added as new independent trials or participants.
- Why unverified: Only the relevant information in the preserved summary is recorded. Detailed source material has not been read, and review of the existing content is incomplete. Independent replication reports under the same conditions and totals of unique trials or participants are not established. Review of the existing content is incomplete.
- Reason for missing information: Independent replication reports under the same conditions and totals of unique trials or participants are not established.
- Required materials and conditions: Report-to-trial, visit, site and denominator relationships and independent replication
- Materials to obtain first: Cohort or protocol relationships between reports and original independent-trial reports
- Further research: A preserved proposal for follow-up research that independently compares the same final and intermediate outcome specifications. No new investigation, calculation or trial was performed.
- Conditions for verification: Relevant source data and analysis details for report-to-trial, visit, site and denominator relationships and independent replication must be provided, with unverified points identified. Preserved wording is linked here; review of the existing content is incomplete.
- Why this condition is needed: This item distinguishes report-to-trial, visit, site and denominator relationships and independent replication to connect the evidence needed for the selected question with the evidence currently available.
- Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
- Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
- Referenced methods: Study/report distinction in M04 §4.6.1–4.6.2; Cohort/outcome linkage is Chamgap application; M04 §4.6.1–4.6.2 and M15 §15.3.1; Chamgap application
- Related sources: S01

### N27 · Persistence and other formulations or skin outcomes

Verification status: Partly verified  
Reading scope: Summary read; external material unread

- Current findings: The manuscript records that positive findings at weeks 4 and 8 were not maintained at the final visit. These are not extended to other skin functions or diseases, general products or sustained long-term efficacy.
- Why unverified: Only the relevant information in the preserved summary is recorded. Detailed source material has not been read, and review of the existing content is incomplete. Other skin endpoints, follow-up beyond 12 weeks and direct comparisons in other populations or formulations are unverified. Review of the existing content is incomplete.
- Reason for missing information: Other skin endpoints, follow-up beyond 12 weeks and direct comparisons in other populations or formulations are unverified.
- Required materials and conditions: Distinction between intermediate changes, sustained effects and other skin or clinical outcomes
- Materials to obtain first: Follow-up, other-endpoint and formulation-specific direct-trial records
- Further research: A preserved proposal for follow-up research that distinguishes persistence from applicability across formulations and populations. No new investigation, calculation or trial was performed.
- Conditions for verification: Relevant source data and analysis details for distinction between intermediate changes, sustained effects and other skin or clinical outcomes must be provided, with unverified points identified. Preserved wording is linked here; review of the existing content is incomplete.
- Why this condition is needed: This item distinguishes distinction between intermediate changes, sustained effects and other skin or clinical outcomes to connect the evidence needed for the selected question with the evidence currently available.
- Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
- Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
- Referenced methods: M03 §3.2.1–3.2.4; dose, duration and effect-modification details are internally designed; M03 §3.2.4; internally defined extension boundaries; M04 §4.6.3, M15 §15.3.1–15.3.3; status separation is internally designed
- Related sources: S01

### N28 · Original safety record and scope

Verification status: Partly verified  
Reading scope: Summary read; external material unread

- Current findings: The original parent safety label is Good, and the manuscript records no reported serious safety signal attributed to the study beverage over 12 weeks. This is not recast as absence of all harms or verification of safety for other products or durations.
- Why unverified: Only the relevant information in the preserved summary is recorded. Detailed source material has not been read, and review of the existing content is incomplete. Adverse-event types, collection and adjudication, group-specific denominators and frequencies, discontinuation, and rare or long-term harms are unverified. Review of the existing content is incomplete.
- Reason for missing information: Adverse-event types, collection and adjudication, group-specific denominators and frequencies, discontinuation, and rare or long-term harms are unverified.
- Required materials and conditions: 12-week safety collection, denominators and frequencies, and rare or long-term harms
- Materials to obtain first: Adverse-event tables, collection methods and discontinuation or follow-up records
- Further research: A preserved proposal for follow-up research that specifies harm collection and the scope of longer-term or other-population evidence. No new investigation, calculation or trial was performed.
- Conditions for verification: Relevant source data and analysis details for 12-week safety collection, denominators and frequencies, and rare or long-term harms must be provided, with unverified points identified. Preserved wording is linked here; review of the existing content is incomplete.
- Why this condition is needed: This item distinguishes 12-week safety collection, denominators and frequencies, and rare or long-term harms to connect the evidence needed for the selected question with the evidence currently available.
- Application exceptions: Complements safety-data gaps for the selected subclaim. Intermediate/final skin hydration, self-reported sleepiness or parent cautionary wording are not used to judge safety or create harm-incidence estimates/new use instructions.
- Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
- Referenced methods: M19 §19.1.2–19.2.4; detailed distinctions are Chamgap’s own design; M19 §19.1.2–19.2.4; Chamgap application; M19 §19.1.2–19.2.4; Chamgap application; M19 §19.1.2–19.2.4; Chamgap application
- Related sources: S01

### N29 · Parent/subclaim, bilingual text and history

Verification status: Partly verified  
Reading scope: Summary read; external material unread

- Current findings: Parent D28, B/S/R1/I0/E0/B1/C0, three false flags and blank override reasons are retained alongside the selected subclaim's grade C and note. Korean and English texts, 2026-08-26, empty correction and deliberation records, and historical cross-checking are not a current review or a subclaim score.
- Why unverified: Only the relevant information in the preserved summary is recorded. Detailed source material has not been read, and review of the existing content is incomplete. Subclaim score, status and axes are absent from the source. No new score, axes or completed review are created. Review of the existing content is incomplete.
- Reason for missing information: Subclaim score, status and axes are absent from the source. No new score, axes or completed review are created.
- Required materials and conditions: Separate preservation of original values, axes, reference date and correction or verification statements
- Materials to obtain first: Original corrections, versions and user correction comments
- Further research: A preserved proposal for follow-up research that distinguishes original values and history from application of new updates. No new investigation, calculation or trial was performed.
- Conditions for verification: Relevant source data and analysis details for separate preservation of original values, axes, reference date and correction or verification statements must be provided, with unverified points identified. Preserved wording is linked here; review of the existing content is incomplete.
- Why this condition is needed: This item distinguishes separate preservation of original values, axes, reference date and correction or verification statements to connect the evidence needed for the selected question with the evidence currently available.
- Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
- Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
- Referenced methods: M04 §4.5, §4.6.3; limits of this material conversion follow the review scope and internal design; M03 §3.1, §3.2.1–3.2.4 question-clarification principles; detailed separation rules are internally designed
- Related sources: S01

### N30 · Summary reading, external materials and links

Verification status: Partly verified  
Reading scope: Summary read; external material unread

- Current findings: The complete preserved summary and references were used for production, and source links are retained. Original articles, registration, protocol, SAP and support or COI materials have not been read or accessed. No separate external-link test was performed.
- Why unverified: Only the relevant information in the preserved summary is recorded. Detailed source material has not been read, and review of the existing content is incomplete. The content and actual accessibility of external original articles, plans and COI materials are unverified. Review of the existing content is incomplete.
- Reason for missing information: The content and actual accessibility of external original articles, plans and COI materials are unverified.
- Required materials and conditions: Actual reading scope and access status of original articles, registration, plans and support records
- Materials to obtain first: External original articles, registration, protocol, SAP and support records, or user input
- Further research: A preserved proposal for follow-up research that distinguishes the timing and scope of acquired material when updating. No new investigation, calculation or trial was performed.
- Conditions for verification: Relevant source data and analysis details for actual reading scope and access status of original articles, registration, plans and support records must be provided, with unverified points identified. Preserved wording is linked here; review of the existing content is incomplete.
- Why this condition is needed: This item distinguishes actual reading scope and access status of original articles, registration, plans and support records to connect the evidence needed for the selected question with the evidence currently available.
- Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
- Remaining uncertainty: This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.
- Referenced methods: M04 §4.5–4.6 material collection/selection principles; acquisition/reading separation and hyperlink specifications are internally designed; M04 §4.5, §4.6.3; limits of this material conversion follow the review scope and internal design
- Related sources: S01

## Evidence and sources

### S01

Sato T et al. 2025

[PubMed](https://pubmed.ncbi.nlm.nih.gov/40151405/)

Materials actually read: Summary read; external material unread  
Findings recorded in the summary: 29.7±7.67 versus 29.7±6.19 a.u., P=0.985; change +8.05±6.85 versus +7.92±5.97, P=0.877; 95% CI not reported. Changes from baseline were positive at week 4, +4.28 versus −2.09 (P<0.001), and week 8, +8.47 versus +5.17 (P=0.002). The difference disappeared by week 12, +8.05 versus +7.92 (P=0.877). A whole-time mixed-model P<0.001 describes different patterns across visits, not a positive week-12 effect.  
Record level: Outcome wording in the stored summary  
Independent replication: S01 Sato2025 is one parallel-trial report involving 220 healthy Japanese adults with dry skin randomized and 213 protocol-compliant participants analyzed. It compared a 65 mL beverage containing 2.2 mg DDMP with an otherwise identical beverage without DDMP for 12 weeks. Changes from baseline at week 4 (+4.28 versus −2.09, P<0.001) and week 8 (+8.47 versus +5.17, P=0.002) are distinguished from final week-12 absolute values (29.7±7.67 versus 29.7±6.19 a.u., P=0.985), changes (+8.05±6.85 versus +7.92±5.97, P=0.877), and the whole-time mixed-model P<0.001. Positive intermediate findings neither replace the prespecified final primary endpoint nor establish sustained benefit. The same groups, visits, skin sites, denominators, references and related sheets are not new independent trials or participants. Report entries are not totals of unique clinical trials, participants or independent replications; no new totals or independence certification are produced.

| Material | Public availability | Access status | Actually read | Notes |
|---|---|---|---|---|
| Stored summary | Stored file | Stored summary | Summary read | Only stored-summary and bibliographic content was used for production. External material verification/review is not complete. |
| External paper | Public availability unverified; only bibliography links preserved | Unread; access not attempted | Not read | No external access or click testing was performed in the original preparation. URLs or registration identifiers alone do not upgrade acquisition/reading status. |
| Registration material | Public availability unverified; only bibliography links preserved | Unread; access not attempted | Not read | No external access or click testing was performed in the original preparation. URLs or registration identifiers alone do not upgrade acquisition/reading status. |
| Protocol | Public availability unverified; only bibliography links preserved | Unread; access not attempted | Not read | No external access or click testing was performed in the original preparation. URLs or registration identifiers alone do not upgrade acquisition/reading status. |
| Statistical analysis plan | Public availability unverified; only bibliography links preserved | Unread; access not attempted | Not read | No external access or click testing was performed in the original preparation. URLs or registration identifiers alone do not upgrade acquisition/reading status. |
| Funding, product-support and COI material | Public availability unverified; only bibliography links preserved | Unread; access not attempted | Not read | No external access or click testing was performed in the original preparation. URLs or registration identifiers alone do not upgrade acquisition/reading status. |

## Review criteria and methods

These are Chamgap's own application conditions, informed by the relevant sections of official methodological guidance. They do not constitute official assessment-tool certification or a new efficacy score.

- M03 [Cochrane Handbook 6.5 (2024), chapter updated 2023-08](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03) · §3.1, §3.2.1–3.2.3, MECIR C5/C7/C13 · Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions. · Preserved method HTML copies; no current method-content re-review or official tool execution
- M04 [Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04) · §4.5, §4.6.1–4.6.3, MECIR C42 · Distinguish studies from reports and link them; do not omit a study solely because results are unreported. · Preserved method HTML copies; no current method-content re-review or official tool execution
- M08 [Cochrane Handbook 6.5 (2024), chapter updated 2019-10](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08) · §8.1–8.2.3, Table 8.2.a · Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting. · Preserved method HTML copies; no current method-content re-review or official tool execution
- M15 [Cochrane Handbook 6.5 (2024), chapter updated 2023-08](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15) · §15.2.4, §15.3.1–15.3.3 · Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision. · Preserved method HTML copies; no current method-content re-review or official tool execution
- M19 [Cochrane Handbook 6.5 (2024), chapter updated 2019-10](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19) · §19.1.2, §19.2.1–19.2.4 · Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates. · Preserved method HTML copies; no current method-content re-review or official tool execution

## What the statuses mean

- Met: Status for necessary evidence confirmed after existing content review. No completion is declared in the current presentation.
- Partly verified: Some information in the stored summary is linked into the table. External comparison/content review is not complete.
- Unverified: The article leaves this unverified, or required material is absent from the current stored summary. This is distinct from zero, absence or safety.
- Review incomplete: Existing content review remains incomplete.
- Not reported: Not reported within the stored material actually read; not extended to the entire primary paper.
- Inaccessible: Means an actual access failure. Access not attempted here is not assigned this state.
- Not applicable: Not used as a substitute for an evidence gap.
- Conflicting data: Requires an observed disagreement under the same comparison criteria; not automatically judged in this production.
- Insufficient evidence for the conditions: Marks a gap in additional material required by the selected conditions; not a new efficacy grade.

## Change history

2026-10-14 · Public page/materials 1.0. The public page and data were prepared from the existing 30 items. No new clinical search, verification-status change or scoring was performed.