{
  "schema_version": "chamgap-public-criteria-1.0",
  "title": "LG2055 drinkable yogurt × Questionnaire symptom-days — PPS, day denominators and infection distinctions",
  "language": "en",
  "translation_date": "2026-10-14",
  "criteria_version": "1.0",
  "criteria_date": "2026-10-06",
  "condition_origin": "Chamgap's own application conditions",
  "method_sources": [
    {
      "id": "M03",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03",
      "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13",
      "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.",
      "review_level": "Link preserved methodological application records; no current clinical-content reassessment or external-link verification was performed."
    },
    {
      "id": "M04",
      "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04",
      "section": "§4.5, §4.6.1–4.6.3, MECIR C42",
      "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.",
      "review_level": "Link preserved methodological application records; no current clinical-content reassessment or external-link verification was performed."
    },
    {
      "id": "M08",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08",
      "section": "§8.1–8.2.3, Table 8.2.a",
      "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.",
      "review_level": "Link preserved methodological application records; no current clinical-content reassessment or external-link verification was performed."
    },
    {
      "id": "M15",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15",
      "section": "§15.2.4, §15.3.1–15.3.3",
      "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.",
      "review_level": "Link preserved methodological application records; no current clinical-content reassessment or external-link verification was performed."
    },
    {
      "id": "M19",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19",
      "section": "§19.1.2, §19.2.1–19.2.4",
      "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.",
      "review_level": "Link preserved methodological application records; no current clinical-content reassessment or external-link verification was performed."
    }
  ],
  "status_dictionary": {
    "Partly verified": "Some information exists in the preserved review summary; detailed original materials remain unverified. This does not certify a passed review or clinical efficacy.",
    "Unverified": "Detailed materials for the selected condition could not be established within the stored scope; this does not mean zero effect, zero studies or safety",
    "Review incomplete": "Review of existing content incomplete",
    "Met": "Use only within the relevant conditions after existing content review; no automatic designation in this preparation",
    "Not reported": "Distinguish only within materials actually read; do not turn unread external materials into unreported findings",
    "Inaccessible": "Not applied during this preparation because actual access was not tested",
    "Not applicable": "Use with a reason for non-applicability based on an explicit question boundary",
    "Conflicting data": "Judge after actual material comparison; review was not performed during this preparation",
    "Insufficient evidence for the conditions": "Do not use as a clinical grade encompassing currently unread materials"
  },
  "requirements": [
    {
      "item_id": "N01",
      "question_type": "Evidence condition",
      "question": "Which existing questionnaire symptom-day claim is being transferred?",
      "needed": "Selected wording, subclaim grade and parent results",
      "role": "Required",
      "role_reason": "Needed to connect selected wording, subclaim grade and parent results with the selected question, actual population/intervention/comparator, endpoints/hierarchy/estimand, denominators/duration and reports/harms.",
      "application_exception": "Distinguish self-reported symptom-days, people/person-days/repeated/concurrent symptoms and symptom-specific numerators/denominators/effects/CIs from confirmed infections/clinical outcomes; distinguish actual strain drink/identical yogurt, winter 12 weeks, allocation/completion/PPS/attrition, advance hierarchy/registration conflict, company involvement and harms. Preserve original numbers only; no new calculations, invented quantities, effects/CIs, grades/reassessment, independence certification or extract/product/drink-consumption, sleep/cold-management, infection-prevention or treatment-replacement instructions.",
      "criterion": "Show originals for selected wording, subclaim grade and parent results with selected-subclaim/parent boundaries, direct endpoints/estimand, denominators and external-reading scope.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Questionnaire symptom definitions, denominators, comparison/time points, estimand and user boundary review. The parent score is not used to fill subclaim values. Only material requests/research needs are recorded; no current lookup or research execution."
    },
    {
      "item_id": "N02",
      "question_type": "Evidence condition",
      "question": "What cold risk and health status characterize the population?",
      "needed": "Healthy Japanese adults aged 20–64 prone to colds",
      "role": "Required",
      "role_reason": "Needed to connect healthy Japanese adults aged 20–64 prone to colds with the selected question, actual population/intervention/comparator, endpoints/hierarchy/estimand, denominators/duration and reports/harms.",
      "application_exception": "Distinguish self-reported symptom-days, people/person-days/repeated/concurrent symptoms and symptom-specific numerators/denominators/effects/CIs from confirmed infections/clinical outcomes; distinguish actual strain drink/identical yogurt, winter 12 weeks, allocation/completion/PPS/attrition, advance hierarchy/registration conflict, company involvement and harms. Preserve original numbers only; no new calculations, invented quantities, effects/CIs, grades/reassessment, independence certification or extract/product/drink-consumption, sleep/cold-management, infection-prevention or treatment-replacement instructions.",
      "criterion": "Show originals for healthy Japanese adults aged 20–64 prone to colds with selected-subclaim/parent boundaries, direct endpoints/estimand, denominators and external-reading scope.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Original materials on cold susceptibility/eligibility, baseline health, comorbidities/medication and vaccination/contact exposure, plus direct results in other populations. Only material requests/research needs are recorded; no current lookup or research execution."
    },
    {
      "item_id": "N03",
      "question_type": "Evidence condition",
      "question": "What is the study identity of the trial drink?",
      "needed": "LG2055 drinkable yogurt versus other probiotics/products",
      "role": "Required",
      "role_reason": "Needed to connect lG2055 drinkable yogurt versus other probiotics/products with the selected question, actual population/intervention/comparator, endpoints/hierarchy/estimand, denominators/duration and reports/harms.",
      "application_exception": "Distinguish self-reported symptom-days, people/person-days/repeated/concurrent symptoms and symptom-specific numerators/denominators/effects/CIs from confirmed infections/clinical outcomes; distinguish actual strain drink/identical yogurt, winter 12 weeks, allocation/completion/PPS/attrition, advance hierarchy/registration conflict, company involvement and harms. Preserve original numbers only; no new calculations, invented quantities, effects/CIs, grades/reassessment, independence certification or extract/product/drink-consumption, sleep/cold-management, infection-prevention or treatment-replacement instructions.",
      "criterion": "Show originals for lG2055 drinkable yogurt versus other probiotics/products with selected-subclaim/parent boundaries, direct endpoints/estimand, denominators and external-reading scope.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Original strain, formulation/quantities, active product/manufacturing and actual exposure/adherence materials. No product/drink consumption or cold/infection-prevention instructions. Only material requests/research needs are recorded; no current lookup or research execution."
    },
    {
      "item_id": "N04",
      "question_type": "Evidence condition",
      "question": "What does the actual identical-yogurt control compare?",
      "needed": "Identical yogurt lacking only LG2055",
      "role": "Required",
      "role_reason": "Needed to connect identical yogurt lacking only LG2055 with the selected question, actual population/intervention/comparator, endpoints/hierarchy/estimand, denominators/duration and reports/harms.",
      "application_exception": "Distinguish self-reported symptom-days, people/person-days/repeated/concurrent symptoms and symptom-specific numerators/denominators/effects/CIs from confirmed infections/clinical outcomes; distinguish actual strain drink/identical yogurt, winter 12 weeks, allocation/completion/PPS/attrition, advance hierarchy/registration conflict, company involvement and harms. Preserve original numbers only; no new calculations, invented quantities, effects/CIs, grades/reassessment, independence certification or extract/product/drink-consumption, sleep/cold-management, infection-prevention or treatment-replacement instructions.",
      "criterion": "Show originals for identical yogurt lacking only LG2055 with selected-subclaim/parent boundaries, direct endpoints/estimand, denominators and external-reading scope.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Group composition, sensory properties/masking, actual product/exposure, concurrent diet/treatment and contact materials. Equality of all conditions is not certified through a new external comparison. Only material requests/research needs are recorded; no current lookup or research execution."
    },
    {
      "item_id": "N05",
      "question_type": "Evidence condition",
      "question": "Are winter 12-week results separated from other durations?",
      "needed": "Observation duration, season and actual exposure",
      "role": "Required",
      "role_reason": "Needed to connect observation duration, season and actual exposure with the selected question, actual population/intervention/comparator, endpoints/hierarchy/estimand, denominators/duration and reports/harms.",
      "application_exception": "Distinguish self-reported symptom-days, people/person-days/repeated/concurrent symptoms and symptom-specific numerators/denominators/effects/CIs from confirmed infections/clinical outcomes; distinguish actual strain drink/identical yogurt, winter 12 weeks, allocation/completion/PPS/attrition, advance hierarchy/registration conflict, company involvement and harms. Preserve original numbers only; no new calculations, invented quantities, effects/CIs, grades/reassessment, independence certification or extract/product/drink-consumption, sleep/cold-management, infection-prevention or treatment-replacement instructions.",
      "criterion": "Show originals for observation duration, season and actual exposure with selected-subclaim/parent boundaries, direct endpoints/estimand, denominators and external-reading scope.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Original actual-exposure/recording duration, missingness/discontinuation, season/infection exposure and time-specific results. No long-term prevention/persistence effects or implementation instructions. Only material requests/research needs are recorded; no current lookup or research execution."
    },
    {
      "item_id": "N06",
      "question_type": "Evidence condition",
      "question": "Are allocation, consumption completion and primary efficacy analyses separate?",
      "needed": "200/198/193 participants and group-specific PPS",
      "role": "Required",
      "role_reason": "Needed to connect 200/198/193 participants and group-specific PPS with the selected question, actual population/intervention/comparator, endpoints/hierarchy/estimand, denominators/duration and reports/harms.",
      "application_exception": "Distinguish self-reported symptom-days, people/person-days/repeated/concurrent symptoms and symptom-specific numerators/denominators/effects/CIs from confirmed infections/clinical outcomes; distinguish actual strain drink/identical yogurt, winter 12 weeks, allocation/completion/PPS/attrition, advance hierarchy/registration conflict, company involvement and harms. Preserve original numbers only; no new calculations, invented quantities, effects/CIs, grades/reassessment, independence certification or extract/product/drink-consumption, sleep/cold-management, infection-prevention or treatment-replacement instructions.",
      "criterion": "Show originals for 200/198/193 participants and group-specific PPS with selected-subclaim/parent boundaries, direct endpoints/estimand, denominators and external-reading scope.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Flow diagrams, group-specific completion/exclusion reasons, endpoint-specific observations/analyses and missing-data handling. 200 randomized participants are not automatically repurposed as efficacy, harm or symptom-day denominators. Only material requests/research needs are recorded; no current lookup or research execution."
    },
    {
      "item_id": "N07",
      "question_type": "Evidence condition",
      "question": "Are PPS results presented as ITT effects for everyone?",
      "needed": "Protocol-compliant completer analysis versus all randomized participants",
      "role": "Required",
      "role_reason": "Needed to connect protocol-compliant completer analysis versus all randomized participants with the selected question, actual population/intervention/comparator, endpoints/hierarchy/estimand, denominators/duration and reports/harms.",
      "application_exception": "Distinguish self-reported symptom-days, people/person-days/repeated/concurrent symptoms and symptom-specific numerators/denominators/effects/CIs from confirmed infections/clinical outcomes; distinguish actual strain drink/identical yogurt, winter 12 weeks, allocation/completion/PPS/attrition, advance hierarchy/registration conflict, company involvement and harms. Preserve original numbers only; no new calculations, invented quantities, effects/CIs, grades/reassessment, independence certification or extract/product/drink-consumption, sleep/cold-management, infection-prevention or treatment-replacement instructions.",
      "criterion": "Show originals for protocol-compliant completer analysis versus all randomized participants with selected-subclaim/parent boundaries, direct endpoints/estimand, denominators and external-reading scope.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Original ITT/other analysis populations, exclusions/missing data and results, and prespecified analysis plans. Positive PPS results are not certified as effects in all randomized participants. Only material requests/research needs are recorded; no current lookup or research execution."
    },
    {
      "item_id": "N08",
      "question_type": "Evidence condition",
      "question": "How are questionnaire symptom-days defined?",
      "needed": "Self-reported days with symptoms and measurement methods",
      "role": "Required",
      "role_reason": "Needed to connect self-reported days with symptoms and measurement methods with the selected question, actual population/intervention/comparator, endpoints/hierarchy/estimand, denominators/duration and reports/harms.",
      "application_exception": "Distinguish self-reported symptom-days, people/person-days/repeated/concurrent symptoms and symptom-specific numerators/denominators/effects/CIs from confirmed infections/clinical outcomes; distinguish actual strain drink/identical yogurt, winter 12 weeks, allocation/completion/PPS/attrition, advance hierarchy/registration conflict, company involvement and harms. Preserve original numbers only; no new calculations, invented quantities, effects/CIs, grades/reassessment, independence certification or extract/product/drink-consumption, sleep/cold-management, infection-prevention or treatment-replacement instructions.",
      "criterion": "Show originals for self-reported days with symptoms and measurement methods with selected-subclaim/parent boundaries, direct endpoints/estimand, denominators and external-reading scope.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Questionnaire tools, symptom-day criteria/concurrent symptoms, recording/missingness, measurement timing, advance plans and original tables. Symptom names are not newly designated as confirmed diagnoses. Only material requests/research needs are recorded; no current lookup or research execution."
    },
    {
      "item_id": "N09",
      "question_type": "Evidence condition",
      "question": "What are the runny-nose numerator, denominator and effect?",
      "needed": "Original symptom-day proportions, absolute difference and P value",
      "role": "Required",
      "role_reason": "Needed to connect original symptom-day proportions, absolute difference and P value with the selected question, actual population/intervention/comparator, endpoints/hierarchy/estimand, denominators/duration and reports/harms.",
      "application_exception": "Distinguish self-reported symptom-days, people/person-days/repeated/concurrent symptoms and symptom-specific numerators/denominators/effects/CIs from confirmed infections/clinical outcomes; distinguish actual strain drink/identical yogurt, winter 12 weeks, allocation/completion/PPS/attrition, advance hierarchy/registration conflict, company involvement and harms. Preserve original numbers only; no new calculations, invented quantities, effects/CIs, grades/reassessment, independence certification or extract/product/drink-consumption, sleep/cold-management, infection-prevention or treatment-replacement instructions.",
      "criterion": "Show originals for original symptom-day proportions, absolute difference and P value with selected-subclaim/parent boundaries, direct endpoints/estimand, denominators and external-reading scope.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Original runny-nose symptom-day tables, group-specific denominator definitions, estimand, analysis model and 95% CI materials. No new recalculation or invented quantitative example. Only material requests/research needs are recorded; no current lookup or research execution."
    },
    {
      "item_id": "N10",
      "question_type": "Evidence condition",
      "question": "Are people, person-days, repeated symptoms and events distinct?",
      "needed": "Symptom-day denominators versus 193-person denominators",
      "role": "Required",
      "role_reason": "Needed to connect symptom-day denominators versus 193-person denominators with the selected question, actual population/intervention/comparator, endpoints/hierarchy/estimand, denominators/duration and reports/harms.",
      "application_exception": "Distinguish self-reported symptom-days, people/person-days/repeated/concurrent symptoms and symptom-specific numerators/denominators/effects/CIs from confirmed infections/clinical outcomes; distinguish actual strain drink/identical yogurt, winter 12 weeks, allocation/completion/PPS/attrition, advance hierarchy/registration conflict, company involvement and harms. Preserve original numbers only; no new calculations, invented quantities, effects/CIs, grades/reassessment, independence certification or extract/product/drink-consumption, sleep/cold-management, infection-prevention or treatment-replacement instructions.",
      "criterion": "Show originals for symptom-day denominators versus 193-person denominators with selected-subclaim/parent boundaries, direct endpoints/estimand, denominators and external-reading scope.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Original recording/denominator units, participant-specific durations, concurrent/repeated symptoms, event definitions and missingness. No new person-day details/totals are calculated. Only material requests/research needs are recorded; no current lookup or research execution."
    },
    {
      "item_id": "N11",
      "question_type": "Evidence condition",
      "question": "Has the correlation structure of repeated records and analyses been verified?",
      "needed": "Models/missing data for repeated symptom-days within people",
      "role": "Required",
      "role_reason": "Needed to connect models/missing data for repeated symptom-days within people with the selected question, actual population/intervention/comparator, endpoints/hierarchy/estimand, denominators/duration and reports/harms.",
      "application_exception": "Distinguish self-reported symptom-days, people/person-days/repeated/concurrent symptoms and symptom-specific numerators/denominators/effects/CIs from confirmed infections/clinical outcomes; distinguish actual strain drink/identical yogurt, winter 12 weeks, allocation/completion/PPS/attrition, advance hierarchy/registration conflict, company involvement and harms. Preserve original numbers only; no new calculations, invented quantities, effects/CIs, grades/reassessment, independence certification or extract/product/drink-consumption, sleep/cold-management, infection-prevention or treatment-replacement instructions.",
      "criterion": "Show originals for models/missing data for repeated symptom-days within people with selected-subclaim/parent boundaries, direct endpoints/estimand, denominators and external-reading scope.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Original estimand, within-participant repetition/correlation, missing observations, aggregation/testing methods and sensitivity analyses. No current model reanalysis or clinical calculation. Only material requests/research needs are recorded; no current lookup or research execution."
    },
    {
      "item_id": "N12",
      "question_type": "Evidence condition",
      "question": "Are other questionnaire symptom results recorded separately?",
      "needed": "Nasal congestion, sneezing, sore throat and hoarseness",
      "role": "Required",
      "role_reason": "Needed to connect nasal congestion, sneezing, sore throat and hoarseness with the selected question, actual population/intervention/comparator, endpoints/hierarchy/estimand, denominators/duration and reports/harms.",
      "application_exception": "Distinguish self-reported symptom-days, people/person-days/repeated/concurrent symptoms and symptom-specific numerators/denominators/effects/CIs from confirmed infections/clinical outcomes; distinguish actual strain drink/identical yogurt, winter 12 weeks, allocation/completion/PPS/attrition, advance hierarchy/registration conflict, company involvement and harms. Preserve original numbers only; no new calculations, invented quantities, effects/CIs, grades/reassessment, independence certification or extract/product/drink-consumption, sleep/cold-management, infection-prevention or treatment-replacement instructions.",
      "criterion": "Show originals for nasal congestion, sneezing, sore throat and hoarseness with selected-subclaim/parent boundaries, direct endpoints/estimand, denominators and external-reading scope.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Original symptom-specific actual numerators/denominators, effects/CIs, models/time points and advance hierarchy. Symptoms are not added as a new composite score or infection event. Only material requests/research needs are recorded; no current lookup or research execution."
    },
    {
      "item_id": "N13",
      "question_type": "Evidence condition",
      "question": "Are missing cough values being filled from its P value?",
      "needed": "Separate cough results and detailed gaps",
      "role": "Supplementary",
      "role_reason": "Needed to connect separate cough results and detailed gaps with the selected question, actual population/intervention/comparator, endpoints/hierarchy/estimand, denominators/duration and reports/harms.",
      "application_exception": "Distinguish self-reported symptom-days, people/person-days/repeated/concurrent symptoms and symptom-specific numerators/denominators/effects/CIs from confirmed infections/clinical outcomes; distinguish actual strain drink/identical yogurt, winter 12 weeks, allocation/completion/PPS/attrition, advance hierarchy/registration conflict, company involvement and harms. Preserve original numbers only; no new calculations, invented quantities, effects/CIs, grades/reassessment, independence certification or extract/product/drink-consumption, sleep/cold-management, infection-prevention or treatment-replacement instructions.",
      "criterion": "Show originals for separate cough results and detailed gaps with selected-subclaim/parent boundaries, direct endpoints/estimand, denominators and external-reading scope.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Original cough tables, denominators, effects/CIs, tests/models and advance hierarchy. No new symptom values or CI estimates. Only material requests/research needs are recorded; no current lookup or research execution."
    },
    {
      "item_id": "N14",
      "question_type": "Evidence condition",
      "question": "Are multiplicity and a composite score across symptoms verified?",
      "needed": "Prespecified hierarchical composite scores versus symptom-specific tests",
      "role": "Required",
      "role_reason": "Needed to connect prespecified hierarchical composite scores versus symptom-specific tests with the selected question, actual population/intervention/comparator, endpoints/hierarchy/estimand, denominators/duration and reports/harms.",
      "application_exception": "Distinguish self-reported symptom-days, people/person-days/repeated/concurrent symptoms and symptom-specific numerators/denominators/effects/CIs from confirmed infections/clinical outcomes; distinguish actual strain drink/identical yogurt, winter 12 weeks, allocation/completion/PPS/attrition, advance hierarchy/registration conflict, company involvement and harms. Preserve original numbers only; no new calculations, invented quantities, effects/CIs, grades/reassessment, independence certification or extract/product/drink-consumption, sleep/cold-management, infection-prevention or treatment-replacement instructions.",
      "criterion": "Show originals for prespecified hierarchical composite scores versus symptom-specific tests with selected-subclaim/parent boundaries, direct endpoints/estimand, denominators and external-reading scope.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Complete endpoint/test lists, registration/protocol/SAP, prespecification/multiple comparisons, selective reporting and original results. No new adjusted P value or grade. Only material requests/research needs are recorded; no current lookup or research execution."
    },
    {
      "item_id": "N15",
      "question_type": "Evidence condition",
      "question": "Is the primary symptom-day specification distinct from the runny-nose example?",
      "needed": "Primary questionnaire symptom-days versus selecting a specific symptom",
      "role": "Required",
      "role_reason": "Needed to connect primary questionnaire symptom-days versus selecting a specific symptom with the selected question, actual population/intervention/comparator, endpoints/hierarchy/estimand, denominators/duration and reports/harms.",
      "application_exception": "Distinguish self-reported symptom-days, people/person-days/repeated/concurrent symptoms and symptom-specific numerators/denominators/effects/CIs from confirmed infections/clinical outcomes; distinguish actual strain drink/identical yogurt, winter 12 weeks, allocation/completion/PPS/attrition, advance hierarchy/registration conflict, company involvement and harms. Preserve original numbers only; no new calculations, invented quantities, effects/CIs, grades/reassessment, independence certification or extract/product/drink-consumption, sleep/cold-management, infection-prevention or treatment-replacement instructions.",
      "criterion": "Show originals for primary questionnaire symptom-days versus selecting a specific symptom with selected-subclaim/parent boundaries, direct endpoints/estimand, denominators and external-reading scope.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Prespecified endpoints/priorities, symptom-specific analyses, complete results and plan/change materials. A selected symptom is not upgraded into a broad conclusion. Only material requests/research needs are recorded; no current lookup or research execution."
    },
    {
      "item_id": "N16",
      "question_type": "Evidence condition",
      "question": "Was laboratory-confirmed infection incidence directly measured?",
      "needed": "Questionnaire symptoms versus pathogen-confirmed infection",
      "role": "Required",
      "role_reason": "Needed to connect questionnaire symptoms versus pathogen-confirmed infection with the selected question, actual population/intervention/comparator, endpoints/hierarchy/estimand, denominators/duration and reports/harms.",
      "application_exception": "Distinguish self-reported symptom-days, people/person-days/repeated/concurrent symptoms and symptom-specific numerators/denominators/effects/CIs from confirmed infections/clinical outcomes; distinguish actual strain drink/identical yogurt, winter 12 weeks, allocation/completion/PPS/attrition, advance hierarchy/registration conflict, company involvement and harms. Preserve original numbers only; no new calculations, invented quantities, effects/CIs, grades/reassessment, independence certification or extract/product/drink-consumption, sleep/cold-management, infection-prevention or treatment-replacement instructions.",
      "criterion": "Show originals for questionnaire symptoms versus pathogen-confirmed infection with selected-subclaim/parent boundaries, direct endpoints/estimand, denominators and external-reading scope.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Test/clinical-confirmation definitions, pathogens, direct group-specific infection events/denominators, follow-up and effects/CIs. Non-measurement is not changed into zero events or zero effect. Only material requests/research needs are recorded; no current lookup or research execution."
    },
    {
      "item_id": "N17",
      "question_type": "Evidence condition",
      "question": "Are severity, health-care use and other clinical outcomes being filled?",
      "needed": "Symptom-days versus severity, clinical visits/hospitalization and absence from work",
      "role": "Required",
      "role_reason": "Needed to connect symptom-days versus severity, clinical visits/hospitalization and absence from work with the selected question, actual population/intervention/comparator, endpoints/hierarchy/estimand, denominators/duration and reports/harms.",
      "application_exception": "Distinguish self-reported symptom-days, people/person-days/repeated/concurrent symptoms and symptom-specific numerators/denominators/effects/CIs from confirmed infections/clinical outcomes; distinguish actual strain drink/identical yogurt, winter 12 weeks, allocation/completion/PPS/attrition, advance hierarchy/registration conflict, company involvement and harms. Preserve original numbers only; no new calculations, invented quantities, effects/CIs, grades/reassessment, independence certification or extract/product/drink-consumption, sleep/cold-management, infection-prevention or treatment-replacement instructions.",
      "criterion": "Show originals for symptom-days versus severity, clinical visits/hospitalization and absence from work with selected-subclaim/parent boundaries, direct endpoints/estimand, denominators and external-reading scope.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Definitions, actual measurement/denominators, comparisons/durations, effects/CIs and originals for each clinical outcome. Symptom-days are not converted into clinical events or treatment effects. Only material requests/research needs are recorded; no current lookup or research execution."
    },
    {
      "item_id": "N18",
      "question_type": "Evidence condition",
      "question": "What gaps remain in 95% CIs and clinical effect size?",
      "needed": "Original absolute difference/P value and unreported 95% CIs",
      "role": "Required",
      "role_reason": "Needed to connect original absolute difference/P value and unreported 95% CIs with the selected question, actual population/intervention/comparator, endpoints/hierarchy/estimand, denominators/duration and reports/harms.",
      "application_exception": "Distinguish self-reported symptom-days, people/person-days/repeated/concurrent symptoms and symptom-specific numerators/denominators/effects/CIs from confirmed infections/clinical outcomes; distinguish actual strain drink/identical yogurt, winter 12 weeks, allocation/completion/PPS/attrition, advance hierarchy/registration conflict, company involvement and harms. Preserve original numbers only; no new calculations, invented quantities, effects/CIs, grades/reassessment, independence certification or extract/product/drink-consumption, sleep/cold-management, infection-prevention or treatment-replacement instructions.",
      "criterion": "Show originals for original absolute difference/P value and unreported 95% CIs with selected-subclaim/parent boundaries, direct endpoints/estimand, denominators and external-reading scope.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Original effect estimates/precision, 95% CIs, prespecified clinical thresholds and denominator/correlation/model materials. Positive results are not expanded into long-term or infection effects. Only material requests/research needs are recorded; no current lookup or research execution."
    },
    {
      "item_id": "N19",
      "question_type": "Evidence condition",
      "question": "Are symptom-days presented as a general immunity effect?",
      "needed": "The product’s added strain versus broad immunity claims",
      "role": "Required",
      "role_reason": "Needed to connect the product’s added strain versus broad immunity claims with the selected question, actual population/intervention/comparator, endpoints/hierarchy/estimand, denominators/duration and reports/harms.",
      "application_exception": "Distinguish self-reported symptom-days, people/person-days/repeated/concurrent symptoms and symptom-specific numerators/denominators/effects/CIs from confirmed infections/clinical outcomes; distinguish actual strain drink/identical yogurt, winter 12 weeks, allocation/completion/PPS/attrition, advance hierarchy/registration conflict, company involvement and harms. Preserve original numbers only; no new calculations, invented quantities, effects/CIs, grades/reassessment, independence certification or extract/product/drink-consumption, sleep/cold-management, infection-prevention or treatment-replacement instructions.",
      "criterion": "Show originals for the product’s added strain versus broad immunity claims with selected-subclaim/parent boundaries, direct endpoints/estimand, denominators and external-reading scope.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Direct endpoints, populations/interventions/comparators, durations, denominators and effects/CIs for each broad claim. No current mechanism, infection-prevention, cold-management or treatment-replacement instructions. Only material requests/research needs are recorded; no current lookup or research execution."
    },
    {
      "item_id": "N20",
      "question_type": "Harm-information gaps supplementing the efficacy table",
      "question": "Are 12-week related safety signals distinct from all harms?",
      "needed": "Serious study-food-related signals and dairy/lactose contexts",
      "role": "Supplementary",
      "role_reason": "Needed to connect serious study-food-related signals and dairy/lactose contexts with the selected question, actual population/intervention/comparator, endpoints/hierarchy/estimand, denominators/duration and reports/harms.",
      "application_exception": "Distinguish self-reported symptom-days, people/person-days/repeated/concurrent symptoms and symptom-specific numerators/denominators/effects/CIs from confirmed infections/clinical outcomes; distinguish actual strain drink/identical yogurt, winter 12 weeks, allocation/completion/PPS/attrition, advance hierarchy/registration conflict, company involvement and harms. Preserve original numbers only; no new calculations, invented quantities, effects/CIs, grades/reassessment, independence certification or extract/product/drink-consumption, sleep/cold-management, infection-prevention or treatment-replacement instructions.",
      "criterion": "Show originals for serious study-food-related signals and dairy/lactose contexts with selected-subclaim/parent boundaries, direct endpoints/estimand, denominators and external-reading scope.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Group-specific AE/SAE collection, actual exposure/denominators, discontinuation/relatedness, allergy/lactose and long-term materials. No new harm rates or product-consumption/cold-management instructions. Only material requests/research needs are recorded; no current lookup or research execution."
    },
    {
      "item_id": "N21",
      "question_type": "Evidence condition",
      "question": "What materials were actually read in this work?",
      "needed": "Preserved JSON summary and external-reading status",
      "role": "Required",
      "role_reason": "Needed to connect preserved JSON summary and external-reading status with the selected question, actual population/intervention/comparator, endpoints/hierarchy/estimand, denominators/duration and reports/harms.",
      "application_exception": "Distinguish self-reported symptom-days, people/person-days/repeated/concurrent symptoms and symptom-specific numerators/denominators/effects/CIs from confirmed infections/clinical outcomes; distinguish actual strain drink/identical yogurt, winter 12 weeks, allocation/completion/PPS/attrition, advance hierarchy/registration conflict, company involvement and harms. Preserve original numbers only; no new calculations, invented quantities, effects/CIs, grades/reassessment, independence certification or extract/product/drink-consumption, sleep/cold-management, infection-prevention or treatment-replacement instructions.",
      "criterion": "Show originals for preserved JSON summary and external-reading status with selected-subclaim/parent boundaries, direct endpoints/estimand, denominators and external-reading scope.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Materials for users to record actual external acquisition/reading scope, versions and timing. No current link/click/access tests. Only material requests/research needs are recorded; no current lookup or research execution."
    },
    {
      "item_id": "N22",
      "question_type": "Evidence condition",
      "question": "Are registration, public dates, plans and current reading distinct?",
      "needed": "Original registration information and detailed plans/access",
      "role": "Required",
      "role_reason": "Needed to connect original registration information and detailed plans/access with the selected question, actual population/intervention/comparator, endpoints/hierarchy/estimand, denominators/duration and reports/harms.",
      "application_exception": "Distinguish self-reported symptom-days, people/person-days/repeated/concurrent symptoms and symptom-specific numerators/denominators/effects/CIs from confirmed infections/clinical outcomes; distinguish actual strain drink/identical yogurt, winter 12 weeks, allocation/completion/PPS/attrition, advance hierarchy/registration conflict, company involvement and harms. Preserve original numbers only; no new calculations, invented quantities, effects/CIs, grades/reassessment, independence certification or extract/product/drink-consumption, sleep/cold-management, infection-prevention or treatment-replacement instructions.",
      "criterion": "Show originals for original registration information and detailed plans/access with selected-subclaim/parent boundaries, direct endpoints/estimand, denominators and external-reading scope.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Original registration texts/versions, public/start/change dates, endpoint/analysis and report-linkage materials. Only historical narratives are preserved; no current prespecification/access certification. Only material requests/research needs are recorded; no current lookup or research execution."
    },
    {
      "item_id": "N23",
      "question_type": "Evidence condition",
      "question": "Were protocol/SAP and endpoint/multiplicity plans acquired?",
      "needed": "Advance plan, change and analysis materials",
      "role": "Required",
      "role_reason": "Needed to connect advance plan, change and analysis materials with the selected question, actual population/intervention/comparator, endpoints/hierarchy/estimand, denominators/duration and reports/harms.",
      "application_exception": "Distinguish self-reported symptom-days, people/person-days/repeated/concurrent symptoms and symptom-specific numerators/denominators/effects/CIs from confirmed infections/clinical outcomes; distinguish actual strain drink/identical yogurt, winter 12 weeks, allocation/completion/PPS/attrition, advance hierarchy/registration conflict, company involvement and harms. Preserve original numbers only; no new calculations, invented quantities, effects/CIs, grades/reassessment, independence certification or extract/product/drink-consumption, sleep/cold-management, infection-prevention or treatment-replacement instructions.",
      "criterion": "Show originals for advance plan, change and analysis materials with selected-subclaim/parent boundaries, direct endpoints/estimand, denominators and external-reading scope.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Protocol, SAP, revision history, complete endpoints/estimands/missingness, multiple comparisons, public dates and paper-comparison materials. Unread external materials are not assumed to mean absent documents. Only material requests/research needs are recorded; no current lookup or research execution."
    },
    {
      "item_id": "N24",
      "question_type": "Evidence condition",
      "question": "Are company funding, product support, employee authors and research roles separate?",
      "needed": "Four categories of company involvement and other support",
      "role": "Required",
      "role_reason": "Needed to connect four categories of company involvement and other support with the selected question, actual population/intervention/comparator, endpoints/hierarchy/estimand, denominators/duration and reports/harms.",
      "application_exception": "Distinguish self-reported symptom-days, people/person-days/repeated/concurrent symptoms and symptom-specific numerators/denominators/effects/CIs from confirmed infections/clinical outcomes; distinguish actual strain drink/identical yogurt, winter 12 weeks, allocation/completion/PPS/attrition, advance hierarchy/registration conflict, company involvement and harms. Preserve original numbers only; no new calculations, invented quantities, effects/CIs, grades/reassessment, independence certification or extract/product/drink-consumption, sleep/cold-management, infection-prevention or treatment-replacement instructions.",
      "criterion": "Show originals for four categories of company involvement and other support with selected-subclaim/parent boundaries, direct endpoints/estimand, denominators and external-reading scope.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Separate originals for company cash funding, product/food manufacturing support, author employment/contractor relationships, design/analysis/data control and other support/COI. The original independence axis is not used as new certification. Only material requests/research needs are recorded; no current lookup or research execution."
    },
    {
      "item_id": "N25",
      "question_type": "Evidence condition",
      "question": "Are narrow positive results, broad-claim gaps and unverified materials distinct?",
      "needed": "Direct endpoints and access/reporting limitations",
      "role": "Required",
      "role_reason": "Needed to connect direct endpoints and access/reporting limitations with the selected question, actual population/intervention/comparator, endpoints/hierarchy/estimand, denominators/duration and reports/harms.",
      "application_exception": "Distinguish self-reported symptom-days, people/person-days/repeated/concurrent symptoms and symptom-specific numerators/denominators/effects/CIs from confirmed infections/clinical outcomes; distinguish actual strain drink/identical yogurt, winter 12 weeks, allocation/completion/PPS/attrition, advance hierarchy/registration conflict, company involvement and harms. Preserve original numbers only; no new calculations, invented quantities, effects/CIs, grades/reassessment, independence certification or extract/product/drink-consumption, sleep/cold-management, infection-prevention or treatment-replacement instructions.",
      "criterion": "Show originals for direct endpoints and access/reporting limitations with selected-subclaim/parent boundaries, direct endpoints/estimand, denominators and external-reading scope.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Materials verifying question-specific actual measurements/definitions, original tables/denominators, plans and actual access scope. Unread is not substituted for unreported, zero studies or zero effect. Only material requests/research needs are recorded; no current lookup or research execution."
    },
    {
      "item_id": "N26",
      "question_type": "Evidence condition",
      "question": "Are reports, trials, people, repeated measures and sibling sheets distinct?",
      "needed": "Document linkage versus unique trials/participants",
      "role": "Required",
      "role_reason": "Needed to connect document linkage versus unique trials/participants with the selected question, actual population/intervention/comparator, endpoints/hierarchy/estimand, denominators/duration and reports/harms.",
      "application_exception": "Distinguish self-reported symptom-days, people/person-days/repeated/concurrent symptoms and symptom-specific numerators/denominators/effects/CIs from confirmed infections/clinical outcomes; distinguish actual strain drink/identical yogurt, winter 12 weeks, allocation/completion/PPS/attrition, advance hierarchy/registration conflict, company involvement and harms. Preserve original numbers only; no new calculations, invented quantities, effects/CIs, grades/reassessment, independence certification or extract/product/drink-consumption, sleep/cold-management, infection-prevention or treatment-replacement instructions.",
      "criterion": "Show originals for document linkage versus unique trials/participants with selected-subclaim/parent boundaries, direct endpoints/estimand, denominators and external-reading scope.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Original registration/report, actual cohort/analysis, endpoint/time-point and repeated-measure relationships. Unique trial counts and unique participant totals remain unrecorded. Only material requests/research needs are recorded; no current lookup or research execution."
    },
    {
      "item_id": "N27",
      "question_type": "Evidence condition",
      "question": "Is there evidence of separate independent confirmation?",
      "needed": "Original R1/I0 versus independent replication",
      "role": "Supplementary",
      "role_reason": "Needed to connect original R1/I0 versus independent replication with the selected question, actual population/intervention/comparator, endpoints/hierarchy/estimand, denominators/duration and reports/harms.",
      "application_exception": "Distinguish self-reported symptom-days, people/person-days/repeated/concurrent symptoms and symptom-specific numerators/denominators/effects/CIs from confirmed infections/clinical outcomes; distinguish actual strain drink/identical yogurt, winter 12 weeks, allocation/completion/PPS/attrition, advance hierarchy/registration conflict, company involvement and harms. Preserve original numbers only; no new calculations, invented quantities, effects/CIs, grades/reassessment, independence certification or extract/product/drink-consumption, sleep/cold-management, infection-prevention or treatment-replacement instructions.",
      "criterion": "Show originals for original R1/I0 versus independent replication with selected-subclaim/parent boundaries, direct endpoints/estimand, denominators and external-reading scope.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Confirmatory materials showing selected-question advance plans, separate populations/comparators, direct endpoints/denominators, effects/CIs, duration/funding and author relationships. No current search or independence judgment. Only material requests/research needs are recorded; no current lookup or research execution."
    },
    {
      "item_id": "N28",
      "question_type": "Evidence condition",
      "question": "Are selected-subclaim and parent scores/axes preserved?",
      "needed": "Subclaim grade/note, absent fields and parent context",
      "role": "Required",
      "role_reason": "Needed to connect subclaim grade/note, absent fields and parent context with the selected question, actual population/intervention/comparator, endpoints/hierarchy/estimand, denominators/duration and reports/harms.",
      "application_exception": "Distinguish self-reported symptom-days, people/person-days/repeated/concurrent symptoms and symptom-specific numerators/denominators/effects/CIs from confirmed infections/clinical outcomes; distinguish actual strain drink/identical yogurt, winter 12 weeks, allocation/completion/PPS/attrition, advance hierarchy/registration conflict, company involvement and harms. Preserve original numbers only; no new calculations, invented quantities, effects/CIs, grades/reassessment, independence certification or extract/product/drink-consumption, sleep/cold-management, infection-prevention or treatment-replacement instructions.",
      "criterion": "Show originals for subclaim grade/note, absent fields and parent context with selected-subclaim/parent boundaries, direct endpoints/estimand, denominators and external-reading scope.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: User subclaim/parent-boundary review and actual correction materials. No new score/grade or official RoB 2/GRADE certification. Only material-request/research needs are recorded; no search/research was performed in this production."
    },
    {
      "item_id": "N29",
      "question_type": "Evidence condition",
      "question": "Are Korean/English wording and absent structured fields preserved?",
      "needed": "Wording in both languages and absent classification fields",
      "role": "Required",
      "role_reason": "Needed to connect wording in both languages and absent classification fields with the selected question, actual population/intervention/comparator, endpoints/hierarchy/estimand, denominators/duration and reports/harms.",
      "application_exception": "Distinguish self-reported symptom-days, people/person-days/repeated/concurrent symptoms and symptom-specific numerators/denominators/effects/CIs from confirmed infections/clinical outcomes; distinguish actual strain drink/identical yogurt, winter 12 weeks, allocation/completion/PPS/attrition, advance hierarchy/registration conflict, company involvement and harms. Preserve original numbers only; no new calculations, invented quantities, effects/CIs, grades/reassessment, independence certification or extract/product/drink-consumption, sleep/cold-management, infection-prevention or treatment-replacement instructions.",
      "criterion": "Show originals for wording in both languages and absent classification fields with selected-subclaim/parent boundaries, direct endpoints/estimand, denominators and external-reading scope.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Materials for content review of bilingual terms, endpoints/durations, absent fields and selected scope. Production explanations remain distinct from original wording. Only material requests/research needs are recorded; no current lookup or research execution."
    },
    {
      "item_id": "N30",
      "question_type": "Evidence condition",
      "question": "Are reference dates, corrections, historical cross-checking and production dates distinct?",
      "needed": "Original 2026-08-26 versus production/application events",
      "role": "Required",
      "role_reason": "Needed to connect original 2026-08-26 versus production/application events with the selected question, actual population/intervention/comparator, endpoints/hierarchy/estimand, denominators/duration and reports/harms.",
      "application_exception": "Distinguish self-reported symptom-days, people/person-days/repeated/concurrent symptoms and symptom-specific numerators/denominators/effects/CIs from confirmed infections/clinical outcomes; distinguish actual strain drink/identical yogurt, winter 12 weeks, allocation/completion/PPS/attrition, advance hierarchy/registration conflict, company involvement and harms. Preserve original numbers only; no new calculations, invented quantities, effects/CIs, grades/reassessment, independence certification or extract/product/drink-consumption, sleep/cold-management, infection-prevention or treatment-replacement instructions.",
      "criterion": "Show originals for original 2026-08-26 versus production/application events with selected-subclaim/parent boundaries, direct endpoints/estimand, denominators and external-reading scope.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: When new materials/corrections arise, materials for separate updates to originals, events, conditions/observations and verdict decisions. Historical narratives are not used as new clinical review. Only material requests/research needs are recorded; no current lookup or research execution."
    },
    {
      "item_id": "N31",
      "question_type": "Evidence condition",
      "question": "What direct materials could fill the selected gaps?",
      "needed": "Definitions, direct endpoints, denominators/effects/CIs and plans",
      "role": "Supplementary",
      "role_reason": "Needed to connect definitions, direct endpoints, denominators/effects/CIs and plans with the selected question, actual population/intervention/comparator, endpoints/hierarchy/estimand, denominators/duration and reports/harms.",
      "application_exception": "Distinguish self-reported symptom-days, people/person-days/repeated/concurrent symptoms and symptom-specific numerators/denominators/effects/CIs from confirmed infections/clinical outcomes; distinguish actual strain drink/identical yogurt, winter 12 weeks, allocation/completion/PPS/attrition, advance hierarchy/registration conflict, company involvement and harms. Preserve original numbers only; no new calculations, invented quantities, effects/CIs, grades/reassessment, independence certification or extract/product/drink-consumption, sleep/cold-management, infection-prevention or treatment-replacement instructions.",
      "criterion": "Show originals for definitions, direct endpoints, denominators/effects/CIs and plans with selected-subclaim/parent boundaries, direct endpoints/estimand, denominators and external-reading scope.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Question-matched advance direct comparisons, overall/symptom-specific denominators, estimands/CIs, measurement/missingness, multiplicity and separate confirmation/long-term harms. Only need is recorded; no current lookup or clinical study. Only material requests/research needs are recorded; no current lookup or research execution."
    },
    {
      "item_id": "N32",
      "question_type": "Evidence condition",
      "question": "Are production, user review and implementation instructions distinct?",
      "needed": "Production request, candidate history and content-review responsibility",
      "role": "Supplementary",
      "role_reason": "Needed to connect production request, candidate history and content-review responsibility with the selected question, actual population/intervention/comparator, endpoints/hierarchy/estimand, denominators/duration and reports/harms.",
      "application_exception": "Distinguish self-reported symptom-days, people/person-days/repeated/concurrent symptoms and symptom-specific numerators/denominators/effects/CIs from confirmed infections/clinical outcomes; distinguish actual strain drink/identical yogurt, winter 12 weeks, allocation/completion/PPS/attrition, advance hierarchy/registration conflict, company involvement and harms. Preserve original numbers only; no new calculations, invented quantities, effects/CIs, grades/reassessment, independence certification or extract/product/drink-consumption, sleep/cold-management, infection-prevention or treatment-replacement instructions.",
      "criterion": "Show originals for production request, candidate history and content-review responsibility with selected-subclaim/parent boundaries, direct endpoints/estimand, denominators and external-reading scope.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Existing content review and later actual-material/correction work. The historical production record did not perform clinical-original comparison, external access, new calculations, grade changes or product/drink-consumption, sleep/cold-management, infection-prevention or treatment-replacement instructions. Only material requests/research needs are recorded; no current lookup or research execution."
    }
  ]
}