# Home balance-board training × Same-ankle recurrence over one year — Events, exposure, adherence and gaps Verdict 2975 · Evidence Check Stored-material review date: Not recorded Original evidence cut-off: 2026-08-26 Review-criteria version: 1.0 Public page/material preparation date: 2026-10-14 Clinical papers were not read directly; existing review summaries were checked. No new clinical-literature search was performed. Unverified does not mean that research is absent or that there is no effect. ## Assessment scope - Population: 2BFit: 522 athletes aged 12–70 after previous ankle sprain, 256/266. The 2023 primary-care app trial had 165 participants; population details remain unidentified and concern separate context. - Ingredient, formulation and route: Eight-week home neuromuscular training with board, exercise sheets, DVD and web materials after usual care, separated from app delivery/bracing comparisons. - Dose: Original study exposure: three times weekly, up to 30 minutes, for eight weeks. 2023 app exposure details remain unverified. No new totals, device/app recommendations or exercise instructions. - Comparator: 2BFit usual care. App-comparator details remain unverified; 2014 bracing comparison/2017 review concern different contexts. - Measured outcome: Same-ankle recurrence over one year; distinguish self-report/independent adjudication, people/repeated events/exposure time and other endpoints. - Duration: 2BFit eight-week intervention/12-month follow-up. App-intervention/follow-up details remain unverified. The 2014 context compared 12-month bracing with eight-week training; the 2017 recurrence context concerned 12 months. - Questions outside this scope: Repurposing specific balance-board-program effects to all apps/ankle exercises/other populations or durations; Mixing app HR, board RR, bracing/review results, people/events/exposure units or denominators; Creating new causality/safety/equivalence/superiority/independence certification from original adherence/attrition/reporting limitations; Adding the same people, ankles, arms, events, times, citations, related sheets and review-included trials as new independent trials/participants; New calculations, invented quantities, effects/CI, grades or device/app recommendations/exercise/rehabilitation/recurrence-prevention/treatment-replacement instructions ## Checklist items ### N01 · Which original one-year recurrence claim is selected? Verification status: Partly verified Reading scope: Preserved summary read; external abstracts/full texts/registrations/protocols/SAP remain unread - Current findings: The selected claim is reduced same-ankle recurrence over one year, original subclaim grade B, with the note 22% versus 33%/NNT 9. Absent subclaim score/status/axes are preserved separately from parent B with 76 points and axes. - Why unverified: Production observation distinguishing selected/parent, identified reports/reference contexts and comparison/endpoint materials in the preserved summary. Detailed originals remain unverified and existing content review incomplete; this does not establish passed review/clinical certification. - Reason for missing information: Exact same-ankle recurrence definition, population/comparator, duration/denominators and user boundary review. Parent scores do not fill the subclaim score. - Required materials and conditions: Selected subclaim wording/grade versus parent context - Materials to obtain first: Exact same-ankle recurrence definition, population/comparator, duration/denominators and user boundary review. Parent scores do not fill the subclaim score. - Further research: Materials needed: Exact same-ankle recurrence definition, population/comparator, duration/denominators and user boundary review. Parent scores do not fill the subclaim score. Only material-request/research needs are recorded; no search/research was performed in this production. - Conditions for verification: Show original materials for selected subclaim wording/grade versus parent context together with selected-subclaim/parent boundaries, direct endpoints/estimands, denominators/exposure and the scope of external reading. - Why this condition is needed: Needed to connect selected subclaim wording/grade versus parent context with the selected question, actual population/intervention/comparator, endpoints/time points/estimands, denominators/repetition/exposure and reports/harms. - Application exceptions: Distinguish 2BFit’s actual post-sprain population, board/sheets/DVD/web support, usual care, eight weeks/one year, self-report/adjudication, people/ankles/events/exposure time, RR/CI/NNT, adherence/contamination/attrition, app/bracing/review contexts, harms and unread materials. Preserve original numbers only; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or device/app recommendations/exercise/rehabilitation/recurrence-prevention/treatment-replacement instructions. - Remaining uncertainty: External original materials remain unread and existing content review is incomplete. Original grades/scores/axes and historical verification/independence descriptions are not upgraded to new verdicts/certification. - Referenced methods: Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production - Related sources: R01 ### N02 · Which previous-sprain population was studied? Verification status: Partly verified Reading scope: Preserved summary read; external abstracts/full texts/registrations/protocols/SAP remain unread - Current findings: 2BFit randomized 522 athletes aged 12–70. The original intervention was home training after usual care following ankle sprain. Injury severity, recovery/start criteria, sports/comorbidities are not established in detail by the summary. - Why unverified: Production observation distinguishing selected/parent, identified reports/reference contexts and comparison/endpoint materials in the preserved summary. Detailed originals remain unverified and existing content review incomplete; this does not establish passed review/clinical certification. - Reason for missing information: Eligibility/exclusions, previous sprain/severity, usual care, training start, exposure and direct other-population data. Do not extend to all ankle disorders/app users. - Required materials and conditions: Athletes aged 12–70 after ankle sprain - Materials to obtain first: Eligibility/exclusions, previous sprain/severity, usual care, training start, exposure and direct other-population data. Do not extend to all ankle disorders/app users. - Further research: Materials needed: Eligibility/exclusions, previous sprain/severity, usual care, training start, exposure and direct other-population data. Do not extend to all ankle disorders/app users. Only material-request/research needs are recorded; no search/research was performed in this production. - Conditions for verification: Show original materials for athletes aged 12–70 after ankle sprain together with selected-subclaim/parent boundaries, direct endpoints/estimands, denominators/exposure and the scope of external reading. - Why this condition is needed: Needed to connect athletes aged 12–70 after ankle sprain with the selected question, actual population/intervention/comparator, endpoints/time points/estimands, denominators/repetition/exposure and reports/harms. - Application exceptions: Distinguish 2BFit’s actual post-sprain population, board/sheets/DVD/web support, usual care, eight weeks/one year, self-report/adjudication, people/ankles/events/exposure time, RR/CI/NNT, adherence/contamination/attrition, app/bracing/review contexts, harms and unread materials. Preserve original numbers only; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or device/app recommendations/exercise/rehabilitation/recurrence-prevention/treatment-replacement instructions. - Remaining uncertainty: External original materials remain unread and existing content review is incomplete. Original grades/scores/axes and historical verification/independence descriptions are not upgraded to new verdicts/certification. - Referenced methods: Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production - Related sources: R01 ### N03 · What was the specific delivery approach? Verification status: Partly verified Reading scope: Preserved summary read; external abstracts/full texts/registrations/protocols/SAP remain unread - Current findings: The original was eight weeks of home neuromuscular training supplying a balance board, exercise sheets, DVD and web materials. Do not simplify into the board’s isolated-component effect, all ankle exercise or app effects. - Why unverified: Production observation distinguishing selected/parent, identified reports/reference contexts and comparison/endpoint materials in the preserved summary. Detailed originals remain unverified and existing content review incomplete; this does not establish passed review/clinical certification. - Reason for missing information: Components, support/contact, training content, adherence, actual products and direct comparisons of delivery approaches. No device/app recommendations or exercise instructions. - Required materials and conditions: Eight-week program with balance board, exercise sheets, DVD and web materials - Materials to obtain first: Components, support/contact, training content, adherence, actual products and direct comparisons of delivery approaches. No device/app recommendations or exercise instructions. - Further research: Materials needed: Components, support/contact, training content, adherence, actual products and direct comparisons of delivery approaches. No device/app recommendations or exercise instructions. Only material-request/research needs are recorded; no search/research was performed in this production. - Conditions for verification: Show original materials for eight-week program with balance board, exercise sheets, DVD and web materials together with selected-subclaim/parent boundaries, direct endpoints/estimands, denominators/exposure and the scope of external reading. - Why this condition is needed: Needed to connect eight-week program with balance board, exercise sheets, DVD and web materials with the selected question, actual population/intervention/comparator, endpoints/time points/estimands, denominators/repetition/exposure and reports/harms. - Application exceptions: Distinguish 2BFit’s actual post-sprain population, board/sheets/DVD/web support, usual care, eight weeks/one year, self-report/adjudication, people/ankles/events/exposure time, RR/CI/NNT, adherence/contamination/attrition, app/bracing/review contexts, harms and unread materials. Preserve original numbers only; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or device/app recommendations/exercise/rehabilitation/recurrence-prevention/treatment-replacement instructions. - Remaining uncertainty: External original materials remain unread and existing content review is incomplete. Original grades/scores/axes and historical verification/independence descriptions are not upgraded to new verdicts/certification. - Referenced methods: Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production - Related sources: R01 ### N04 · What were usual-care comparison and concurrent treatment? Verification status: Partly verified Reading scope: Preserved summary read; external abstracts/full texts/registrations/protocols/SAP remain unread - Current findings: Original design was a multicentre randomized usual-care-controlled trial; effects concern adding an eight-week program after usual care. Actual concurrent bracing, physiotherapy, medication, return-to-sport/exposure in both arms remain unverified. - Why unverified: Production observation distinguishing selected/parent, identified reports/reference contexts and comparison/endpoint materials in the preserved summary. Detailed originals remain unverified and existing content review incomplete; this does not establish passed review/clinical certification. - Reason for missing information: Original usual care, additional training/other exposure, contact, contamination and recovery/return criteria in both arms. Do not repurpose effects to no treatment/other comparators. - Required materials and conditions: Additional training after usual care - Materials to obtain first: Original usual care, additional training/other exposure, contact, contamination and recovery/return criteria in both arms. Do not repurpose effects to no treatment/other comparators. - Further research: Materials needed: Original usual care, additional training/other exposure, contact, contamination and recovery/return criteria in both arms. Do not repurpose effects to no treatment/other comparators. Only material-request/research needs are recorded; no search/research was performed in this production. - Conditions for verification: Show original materials for additional training after usual care together with selected-subclaim/parent boundaries, direct endpoints/estimands, denominators/exposure and the scope of external reading. - Why this condition is needed: Needed to connect additional training after usual care with the selected question, actual population/intervention/comparator, endpoints/time points/estimands, denominators/repetition/exposure and reports/harms. - Application exceptions: Distinguish 2BFit’s actual post-sprain population, board/sheets/DVD/web support, usual care, eight weeks/one year, self-report/adjudication, people/ankles/events/exposure time, RR/CI/NNT, adherence/contamination/attrition, app/bracing/review contexts, harms and unread materials. Preserve original numbers only; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or device/app recommendations/exercise/rehabilitation/recurrence-prevention/treatment-replacement instructions. - Remaining uncertainty: External original materials remain unread and existing content review is incomplete. Original grades/scores/axes and historical verification/independence descriptions are not upgraded to new verdicts/certification. - Referenced methods: Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production - Related sources: R01 ### N05 · Are training duration/study exposure separated from use instructions? Verification status: Partly verified Reading scope: Preserved summary read; external abstracts/full texts/registrations/protocols/SAP remain unread - Current findings: Original study facts record three sessions weekly, up to 30 minutes each, for eight weeks. Preserve study-exposure identity only; do not calculate total sessions/time or create exercise/rehabilitation/prevention instructions. - Why unverified: Production observation distinguishing selected/parent, identified reports/reference contexts and comparison/endpoint materials in the preserved summary. Detailed originals remain unverified and existing content review incomplete; this does not establish passed review/clinical certification. - Reason for missing information: Original actual training, adherence/stopping, support/contact and phase-specific exposure. No certification of identical effects for other durations/intensities. - Required materials and conditions: Original eight weeks, three times weekly, up to 30 minutes - Materials to obtain first: Original actual training, adherence/stopping, support/contact and phase-specific exposure. No certification of identical effects for other durations/intensities. - Further research: Materials needed: Original actual training, adherence/stopping, support/contact and phase-specific exposure. No certification of identical effects for other durations/intensities. Only material-request/research needs are recorded; no search/research was performed in this production. - Conditions for verification: Show original materials for original eight weeks, three times weekly, up to 30 minutes together with selected-subclaim/parent boundaries, direct endpoints/estimands, denominators/exposure and the scope of external reading. - Why this condition is needed: Needed to connect original eight weeks, three times weekly, up to 30 minutes with the selected question, actual population/intervention/comparator, endpoints/time points/estimands, denominators/repetition/exposure and reports/harms. - Application exceptions: Distinguish 2BFit’s actual post-sprain population, board/sheets/DVD/web support, usual care, eight weeks/one year, self-report/adjudication, people/ankles/events/exposure time, RR/CI/NNT, adherence/contamination/attrition, app/bracing/review contexts, harms and unread materials. Preserve original numbers only; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or device/app recommendations/exercise/rehabilitation/recurrence-prevention/treatment-replacement instructions. - Remaining uncertainty: External original materials remain unread and existing content review is incomplete. Original grades/scores/axes and historical verification/independence descriptions are not upgraded to new verdicts/certification. - Referenced methods: Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production - Related sources: R01 ### N06 · Are eight-week training and one-year outcomes separated? Verification status: Partly verified Reading scope: Preserved summary read; external abstracts/full texts/registrations/protocols/SAP remain unread - Current findings: Intervention lasted eight weeks and same-ankle recurrence follow-up lasted 12 months. Maintenance training after completion, follow-up exposure/stopping and visit-specific observation remain unverified in detail. Training and event-observation periods do not become the same denominator. - Why unverified: Production observation distinguishing selected/parent, identified reports/reference contexts and comparison/endpoint materials in the preserved summary. Detailed originals remain unverified and existing content review incomplete; this does not establish passed review/clinical certification. - Reason for missing information: Original actual training/maintenance, follow-up schedules, observation duration/loss and sports exposure. Do not calculate new day counts/exercise amounts from one year. - Required materials and conditions: Intervention duration versus 12-month recurrence follow-up - Materials to obtain first: Original actual training/maintenance, follow-up schedules, observation duration/loss and sports exposure. Do not calculate new day counts/exercise amounts from one year. - Further research: Materials needed: Original actual training/maintenance, follow-up schedules, observation duration/loss and sports exposure. Do not calculate new day counts/exercise amounts from one year. Only material-request/research needs are recorded; no search/research was performed in this production. - Conditions for verification: Show original materials for intervention duration versus 12-month recurrence follow-up together with selected-subclaim/parent boundaries, direct endpoints/estimands, denominators/exposure and the scope of external reading. - Why this condition is needed: Needed to connect intervention duration versus 12-month recurrence follow-up with the selected question, actual population/intervention/comparator, endpoints/time points/estimands, denominators/repetition/exposure and reports/harms. - Application exceptions: Distinguish 2BFit’s actual post-sprain population, board/sheets/DVD/web support, usual care, eight weeks/one year, self-report/adjudication, people/ankles/events/exposure time, RR/CI/NNT, adherence/contamination/attrition, app/bracing/review contexts, harms and unread materials. Preserve original numbers only; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or device/app recommendations/exercise/rehabilitation/recurrence-prevention/treatment-replacement instructions. - Remaining uncertainty: External original materials remain unread and existing content review is incomplete. Original grades/scores/axes and historical verification/independence descriptions are not upgraded to new verdicts/certification. - Referenced methods: Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production - Related sources: R01 ### N07 · What are randomization and recurrence numerators? Verification status: Partly verified Reading scope: Preserved summary read; external abstracts/full texts/registrations/protocols/SAP remain unread - Current findings: The original records 522 randomized (256/266) and 56/256 (22%) versus 89/266 (33%). Separately retain relationships among people, ankles, recurrence events, repeated reports and time; do not calculate additional event/participant totals. - Why unverified: Production observation distinguishing selected/parent, identified reports/reference contexts and comparison/endpoint materials in the preserved summary. Detailed originals remain unverified and existing content review incomplete; this does not establish passed review/clinical certification. - Reason for missing information: Endpoint-numerator definitions, arm analysis/follow-up/observed denominators, repeated-recurrence handling and original flow tables. Do not copy numerators/denominators to all other endpoints/trials. - Required materials and conditions: 522 participants, 256/266, original recurrence 56/89 - Materials to obtain first: Endpoint-numerator definitions, arm analysis/follow-up/observed denominators, repeated-recurrence handling and original flow tables. Do not copy numerators/denominators to all other endpoints/trials. - Further research: Materials needed: Endpoint-numerator definitions, arm analysis/follow-up/observed denominators, repeated-recurrence handling and original flow tables. Do not copy numerators/denominators to all other endpoints/trials. Only material-request/research needs are recorded; no search/research was performed in this production. - Conditions for verification: Show original materials for 522 participants, 256/266, original recurrence 56/89 together with selected-subclaim/parent boundaries, direct endpoints/estimands, denominators/exposure and the scope of external reading. - Why this condition is needed: Needed to connect 522 participants, 256/266, original recurrence 56/89 with the selected question, actual population/intervention/comparator, endpoints/time points/estimands, denominators/repetition/exposure and reports/harms. - Application exceptions: Distinguish 2BFit’s actual post-sprain population, board/sheets/DVD/web support, usual care, eight weeks/one year, self-report/adjudication, people/ankles/events/exposure time, RR/CI/NNT, adherence/contamination/attrition, app/bracing/review contexts, harms and unread materials. Preserve original numbers only; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or device/app recommendations/exercise/rehabilitation/recurrence-prevention/treatment-replacement instructions. - Remaining uncertainty: External original materials remain unread and existing content review is incomplete. Original grades/scores/axes and historical verification/independence descriptions are not upgraded to new verdicts/certification. - Referenced methods: Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production - Related sources: R01 ### N08 · How was same-ankle recurrence defined? Verification status: Partly verified Reading scope: Preserved summary read; external abstracts/full texts/registrations/protocols/SAP remain unread - Current findings: The original endpoint was same-ankle recurrence reported monthly and independently adjudicated under masking. Diagnostic/injury/recurrence criteria, first/all-repeated-event handling and clinical-confirmation details remain unverified. Do not extend to the opposite ankle/all injuries. - Why unverified: Production observation distinguishing selected/parent, identified reports/reference contexts and comparison/endpoint materials in the preserved summary. Detailed originals remain unverified and existing content review incomplete; this does not establish passed review/clinical certification. - Reason for missing information: Event definitions, original questionnaires, adjudication rules, repeated/contralateral events, severity and confirmation data. Materials clarifying aggregation of original numerators 56/89. - Required materials and conditions: Original event label, first/repeated events and confirmation - Materials to obtain first: Event definitions, original questionnaires, adjudication rules, repeated/contralateral events, severity and confirmation data. Materials clarifying aggregation of original numerators 56/89. - Further research: Materials needed: Event definitions, original questionnaires, adjudication rules, repeated/contralateral events, severity and confirmation data. Materials clarifying aggregation of original numerators 56/89. Only material-request/research needs are recorded; no search/research was performed in this production. - Conditions for verification: Show original materials for original event label, first/repeated events and confirmation together with selected-subclaim/parent boundaries, direct endpoints/estimands, denominators/exposure and the scope of external reading. - Why this condition is needed: Needed to connect original event label, first/repeated events and confirmation with the selected question, actual population/intervention/comparator, endpoints/time points/estimands, denominators/repetition/exposure and reports/harms. - Application exceptions: Distinguish 2BFit’s actual post-sprain population, board/sheets/DVD/web support, usual care, eight weeks/one year, self-report/adjudication, people/ankles/events/exposure time, RR/CI/NNT, adherence/contamination/attrition, app/bracing/review contexts, harms and unread materials. Preserve original numbers only; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or device/app recommendations/exercise/rehabilitation/recurrence-prevention/treatment-replacement instructions. - Remaining uncertainty: External original materials remain unread and existing content review is incomplete. Original grades/scores/axes and historical verification/independence descriptions are not upgraded to new verdicts/certification. - Referenced methods: Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production - Related sources: R01 ### N09 · Are self-reporting and masked adjudication separated? Verification status: Partly verified Reading scope: Preserved summary read; external abstracts/full texts/registrations/protocols/SAP remain unread - Current findings: The original records monthly self-reports followed by independent adjudication by a masked physiotherapist and researcher. Initial reporting was self-reported and participant masking impossible. Do not add a declaration that all reports were confirmed through testing/clinical visits. - Why unverified: Production observation distinguishing selected/parent, identified reports/reference contexts and comparison/endpoint materials in the preserved summary. Detailed originals remain unverified and existing content review incomplete; this does not establish passed review/clinical certification. - Reason for missing information: Original reporting/missingness, disagreement/adjudication, assessor masking, objective confirmation and participant expectations. No formal RoB assessment in this production. - Required materials and conditions: Initial monthly reporting versus independent physiotherapist/researcher adjudication - Materials to obtain first: Original reporting/missingness, disagreement/adjudication, assessor masking, objective confirmation and participant expectations. No formal RoB assessment in this production. - Further research: Materials needed: Original reporting/missingness, disagreement/adjudication, assessor masking, objective confirmation and participant expectations. No formal RoB assessment in this production. Only material-request/research needs are recorded; no search/research was performed in this production. - Conditions for verification: Show original materials for initial monthly reporting versus independent physiotherapist/researcher adjudication together with selected-subclaim/parent boundaries, direct endpoints/estimands, denominators/exposure and the scope of external reading. - Why this condition is needed: Needed to connect initial monthly reporting versus independent physiotherapist/researcher adjudication with the selected question, actual population/intervention/comparator, endpoints/time points/estimands, denominators/repetition/exposure and reports/harms. - Application exceptions: Distinguish 2BFit’s actual post-sprain population, board/sheets/DVD/web support, usual care, eight weeks/one year, self-report/adjudication, people/ankles/events/exposure time, RR/CI/NNT, adherence/contamination/attrition, app/bracing/review contexts, harms and unread materials. Preserve original numbers only; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or device/app recommendations/exercise/rehabilitation/recurrence-prevention/treatment-replacement instructions. - Remaining uncertainty: External original materials remain unread and existing content review is incomplete. Original grades/scores/axes and historical verification/independence descriptions are not upgraded to new verdicts/certification. - Referenced methods: Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production - Related sources: R01 ### N10 · Are recurrent people, repeated events and observations separated? Verification status: Partly verified Reading scope: Preserved summary read; external abstracts/full texts/registrations/protocols/SAP remain unread - Current findings: Preserve original 56/256, 89/266 and monthly reporting. Exact aggregation of at-least-one recurrence, first/all-repeated events and same-person bilateral-ankle/report relationships remains unverified. Monthly/repeated events are not new independent participants. - Why unverified: Production observation distinguishing selected/parent, identified reports/reference contexts and comparison/endpoint materials in the preserved summary. Detailed originals remain unverified and existing content review incomplete; this does not establish passed review/clinical certification. - Reason for missing information: Original event aggregation, person/ankle identifiers, repeat handling, analysis units and observation periods. No additional participant/event counts or new incidence-rate calculations. - Required materials and conditions: Original numerators and people/ankle/event units - Materials to obtain first: Original event aggregation, person/ankle identifiers, repeat handling, analysis units and observation periods. No additional participant/event counts or new incidence-rate calculations. - Further research: Materials needed: Original event aggregation, person/ankle identifiers, repeat handling, analysis units and observation periods. No additional participant/event counts or new incidence-rate calculations. Only material-request/research needs are recorded; no search/research was performed in this production. - Conditions for verification: Show original materials for original numerators and people/ankle/event units together with selected-subclaim/parent boundaries, direct endpoints/estimands, denominators/exposure and the scope of external reading. - Why this condition is needed: Needed to connect original numerators and people/ankle/event units with the selected question, actual population/intervention/comparator, endpoints/time points/estimands, denominators/repetition/exposure and reports/harms. - Application exceptions: Distinguish 2BFit’s actual post-sprain population, board/sheets/DVD/web support, usual care, eight weeks/one year, self-report/adjudication, people/ankles/events/exposure time, RR/CI/NNT, adherence/contamination/attrition, app/bracing/review contexts, harms and unread materials. Preserve original numbers only; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or device/app recommendations/exercise/rehabilitation/recurrence-prevention/treatment-replacement instructions. - Remaining uncertainty: External original materials remain unread and existing content review is incomplete. Original grades/scores/axes and historical verification/independence descriptions are not upgraded to new verdicts/certification. - Referenced methods: Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production - Related sources: R01 ### N11 · Which comparison do adjusted RR/CI/NNT describe? Verification status: Partly verified Reading scope: Preserved summary read; external abstracts/full texts/registrations/protocols/SAP remain unread - Current findings: Original adjusted RR 0.63 (95% CI 0.45–0.88) and NNT 9 concern 2BFit same-ankle recurrence over one year. Do not copy to app/bracing or time-loss/cost endpoints. Original adjusted-model/estimand details remain unverified. - Why unverified: Production observation distinguishing selected/parent, identified reports/reference contexts and comparison/endpoint materials in the preserved summary. Detailed originals remain unverified and existing content review incomplete; this does not establish passed review/clinical certification. - Reason for missing information: Original models/adjustment variables, effects/CI, NNT definition/denominators and estimands. No new RR/RRR/NNT/CI recalculation or invented examples. - Required materials and conditions: 2BFit one-year recurrence effects - Materials to obtain first: Original models/adjustment variables, effects/CI, NNT definition/denominators and estimands. No new RR/RRR/NNT/CI recalculation or invented examples. - Further research: Materials needed: Original models/adjustment variables, effects/CI, NNT definition/denominators and estimands. No new RR/RRR/NNT/CI recalculation or invented examples. Only material-request/research needs are recorded; no search/research was performed in this production. - Conditions for verification: Show original materials for 2BFit one-year recurrence effects together with selected-subclaim/parent boundaries, direct endpoints/estimands, denominators/exposure and the scope of external reading. - Why this condition is needed: Needed to connect 2BFit one-year recurrence effects with the selected question, actual population/intervention/comparator, endpoints/time points/estimands, denominators/repetition/exposure and reports/harms. - Application exceptions: Distinguish 2BFit’s actual post-sprain population, board/sheets/DVD/web support, usual care, eight weeks/one year, self-report/adjudication, people/ankles/events/exposure time, RR/CI/NNT, adherence/contamination/attrition, app/bracing/review contexts, harms and unread materials. Preserve original numbers only; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or device/app recommendations/exercise/rehabilitation/recurrence-prevention/treatment-replacement instructions. - Remaining uncertainty: External original materials remain unread and existing content review is incomplete. Original grades/scores/axes and historical verification/independence descriptions are not upgraded to new verdicts/certification. - Referenced methods: Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production - Related sources: R01 ### N12 · Are original absolute difference and arm percentages distinguished? Verification status: Partly verified Reading scope: Preserved summary read; external abstracts/full texts/registrations/protocols/SAP remain unread - Current findings: The original crux/rationale records 22% versus 33% and absolute recurrence difference −11 percentage points. Do not transfer to within-arm improvement, relative effects, other ankles/apps or calculate exact unrounded values/new absolute differences. - Why unverified: Production observation distinguishing selected/parent, identified reports/reference contexts and comparison/endpoint materials in the preserved summary. Detailed originals remain unverified and existing content review incomplete; this does not establish passed review/clinical certification. - Reason for missing information: Original arm denominators/rounding, effect definitions, adjusted/unadjusted results and duration/analysis data. Do not newly convert RR and absolute differences into one another. - Required materials and conditions: 22% versus 33% and original −11 percentage points - Materials to obtain first: Original arm denominators/rounding, effect definitions, adjusted/unadjusted results and duration/analysis data. Do not newly convert RR and absolute differences into one another. - Further research: Materials needed: Original arm denominators/rounding, effect definitions, adjusted/unadjusted results and duration/analysis data. Do not newly convert RR and absolute differences into one another. Only material-request/research needs are recorded; no search/research was performed in this production. - Conditions for verification: Show original materials for 22% versus 33% and original −11 percentage points together with selected-subclaim/parent boundaries, direct endpoints/estimands, denominators/exposure and the scope of external reading. - Why this condition is needed: Needed to connect 22% versus 33% and original −11 percentage points with the selected question, actual population/intervention/comparator, endpoints/time points/estimands, denominators/repetition/exposure and reports/harms. - Application exceptions: Distinguish 2BFit’s actual post-sprain population, board/sheets/DVD/web support, usual care, eight weeks/one year, self-report/adjudication, people/ankles/events/exposure time, RR/CI/NNT, adherence/contamination/attrition, app/bracing/review contexts, harms and unread materials. Preserve original numbers only; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or device/app recommendations/exercise/rehabilitation/recurrence-prevention/treatment-replacement instructions. - Remaining uncertainty: External original materials remain unread and existing content review is incomplete. Original grades/scores/axes and historical verification/independence descriptions are not upgraded to new verdicts/certification. - Referenced methods: Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production - Related sources: R01 ### N13 · Are exposure-time incidence density and one-year risk identical? Verification status: Partly verified Reading scope: Preserved summary read; external abstracts/full texts/registrations/protocols/SAP remain unread - Current findings: Original study facts record incidence density 1.86 versus 2.90 per 1,000 ankle-exposure hours. These differ in units from 22% versus 33% with person denominators. Do not calculate actual total exposure hours, new event counts/incidence-density ratios. - Why unverified: Production observation distinguishing selected/parent, identified reports/reference contexts and comparison/endpoint materials in the preserved summary. Detailed originals remain unverified and existing content review incomplete; this does not establish passed review/clinical certification. - Reason for missing information: Actual arm sports exposure, recording/missingness, incidence-density numerators/denominators and models/CI. Distinguish time, people and ankle units. - Required materials and conditions: 1.86 versus 2.90 per 1,000 hours - Materials to obtain first: Actual arm sports exposure, recording/missingness, incidence-density numerators/denominators and models/CI. Distinguish time, people and ankle units. - Further research: Materials needed: Actual arm sports exposure, recording/missingness, incidence-density numerators/denominators and models/CI. Distinguish time, people and ankle units. Only material-request/research needs are recorded; no search/research was performed in this production. - Conditions for verification: Show original materials for 1.86 versus 2.90 per 1,000 hours together with selected-subclaim/parent boundaries, direct endpoints/estimands, denominators/exposure and the scope of external reading. - Why this condition is needed: Needed to connect 1.86 versus 2.90 per 1,000 hours with the selected question, actual population/intervention/comparator, endpoints/time points/estimands, denominators/repetition/exposure and reports/harms. - Application exceptions: Distinguish 2BFit’s actual post-sprain population, board/sheets/DVD/web support, usual care, eight weeks/one year, self-report/adjudication, people/ankles/events/exposure time, RR/CI/NNT, adherence/contamination/attrition, app/bracing/review contexts, harms and unread materials. Preserve original numbers only; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or device/app recommendations/exercise/rehabilitation/recurrence-prevention/treatment-replacement instructions. - Remaining uncertainty: External original materials remain unread and existing content review is incomplete. Original grades/scores/axes and historical verification/independence descriptions are not upgraded to new verdicts/certification. - Referenced methods: Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production - Related sources: R01 ### N14 · Are time-loss and cost/productivity outcomes retained separately? Verification status: Partly verified Reading scope: Preserved summary read; external abstracts/full texts/registrations/protocols/SAP remain unread - Current findings: The original rationale records time-loss recurrence RR 0.53 and medical-cost/productivity-loss recurrence RR 0.25 in the same direction. Definitions, numerators/denominators, CI/times/models remain unverified in detail. Do not copy primary RR 0.63/CI or NNT 9. - Why unverified: Production observation distinguishing selected/parent, identified reports/reference contexts and comparison/endpoint materials in the preserved summary. Detailed originals remain unverified and existing content review incomplete; this does not establish passed review/clinical certification. - Reason for missing information: Original endpoint tables, event/cost definitions, denominators, effects/CI and hierarchy/multiplicity. No new calculations/addition beyond original numbers. - Required materials and conditions: Other recurrence outcomes, RR 0.53 and 0.25 - Materials to obtain first: Original endpoint tables, event/cost definitions, denominators, effects/CI and hierarchy/multiplicity. No new calculations/addition beyond original numbers. - Further research: Materials needed: Original endpoint tables, event/cost definitions, denominators, effects/CI and hierarchy/multiplicity. No new calculations/addition beyond original numbers. Only material-request/research needs are recorded; no search/research was performed in this production. - Conditions for verification: Show original materials for other recurrence outcomes, RR 0.53 and 0.25 together with selected-subclaim/parent boundaries, direct endpoints/estimands, denominators/exposure and the scope of external reading. - Why this condition is needed: Needed to connect other recurrence outcomes, RR 0.53 and 0.25 with the selected question, actual population/intervention/comparator, endpoints/time points/estimands, denominators/repetition/exposure and reports/harms. - Application exceptions: Distinguish 2BFit’s actual post-sprain population, board/sheets/DVD/web support, usual care, eight weeks/one year, self-report/adjudication, people/ankles/events/exposure time, RR/CI/NNT, adherence/contamination/attrition, app/bracing/review contexts, harms and unread materials. Preserve original numbers only; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or device/app recommendations/exercise/rehabilitation/recurrence-prevention/treatment-replacement instructions. - Remaining uncertainty: External original materials remain unread and existing content review is incomplete. Original grades/scores/axes and historical verification/independence descriptions are not upgraded to new verdicts/certification. - Referenced methods: Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production - Related sources: R01 ### N15 · Are adherence, comparator contamination and attrition retained together? Verification status: Partly verified Reading scope: Preserved summary read; external abstracts/full texts/registrations/protocols/SAP remain unread - Current findings: Preserve original full adherence 58/256 (23%), comparator contamination 5/266 (2%) and follow-up attrition 14%. Adherence definition, partial adherence and arm-specific loss/reasons remain unverified in detail. No adherer effects, new adherence differences/attrition counts/rates. - Why unverified: Production observation distinguishing selected/parent, identified reports/reference contexts and comparison/endpoint materials in the preserved summary. Detailed originals remain unverified and existing content review incomplete; this does not establish passed review/clinical certification. - Reason for missing information: Adherence measurement, actual exposure, contamination/concurrent training, arm withdrawal/missingness and sensitivity analyses. Low adherence does not newly establish delivery effects/causality. - Required materials and conditions: 58/25623%·5/2662%·14% - Materials to obtain first: Adherence measurement, actual exposure, contamination/concurrent training, arm withdrawal/missingness and sensitivity analyses. Low adherence does not newly establish delivery effects/causality. - Further research: Materials needed: Adherence measurement, actual exposure, contamination/concurrent training, arm withdrawal/missingness and sensitivity analyses. Low adherence does not newly establish delivery effects/causality. Only material-request/research needs are recorded; no search/research was performed in this production. - Conditions for verification: Show original materials for 58/256 (23%), 5/266 (2%) and 14% together with selected-subclaim/parent boundaries, direct endpoints/estimands, denominators/exposure and the scope of external reading. - Why this condition is needed: Needed to connect 58/256 (23%), 5/266 (2%) and 14% with the selected question, actual population/intervention/comparator, endpoints/time points/estimands, denominators/repetition/exposure and reports/harms. - Application exceptions: Distinguish 2BFit’s actual post-sprain population, board/sheets/DVD/web support, usual care, eight weeks/one year, self-report/adjudication, people/ankles/events/exposure time, RR/CI/NNT, adherence/contamination/attrition, app/bracing/review contexts, harms and unread materials. Preserve original numbers only; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or device/app recommendations/exercise/rehabilitation/recurrence-prevention/treatment-replacement instructions. - Remaining uncertainty: External original materials remain unread and existing content review is incomplete. Original grades/scores/axes and historical verification/independence descriptions are not upgraded to new verdicts/certification. - Referenced methods: Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production - Related sources: R01 ### N16 · Does ITT certify resolution of completeness/missingness? Verification status: Partly verified Reading scope: Preserved summary read; external abstracts/full texts/registrations/protocols/SAP remain unread - Current findings: The original study description records all analyses following ITT principles alongside 14% attrition. ITT is not converted into universal completion/all-endpoint observation or zero missingness bias. Original B0 is parent-verdict context. - Why unverified: Production observation distinguishing selected/parent, identified reports/reference contexts and comparison/endpoint materials in the preserved summary. Detailed originals remain unverified and existing content review incomplete; this does not establish passed review/clinical certification. - Reason for missing information: Original arm flow, endpoint analysis/observation, missingness handling/assumptions, follow-up loss and sensitivity. No clinical calculations/formal risk assessment in this production. - Required materials and conditions: Analysis as randomized and actual missingness handling - Materials to obtain first: Original arm flow, endpoint analysis/observation, missingness handling/assumptions, follow-up loss and sensitivity. No clinical calculations/formal risk assessment in this production. - Further research: Materials needed: Original arm flow, endpoint analysis/observation, missingness handling/assumptions, follow-up loss and sensitivity. No clinical calculations/formal risk assessment in this production. Only material-request/research needs are recorded; no search/research was performed in this production. - Conditions for verification: Show original materials for analysis as randomized and actual missingness handling together with selected-subclaim/parent boundaries, direct endpoints/estimands, denominators/exposure and the scope of external reading. - Why this condition is needed: Needed to connect analysis as randomized and actual missingness handling with the selected question, actual population/intervention/comparator, endpoints/time points/estimands, denominators/repetition/exposure and reports/harms. - Application exceptions: Distinguish 2BFit’s actual post-sprain population, board/sheets/DVD/web support, usual care, eight weeks/one year, self-report/adjudication, people/ankles/events/exposure time, RR/CI/NNT, adherence/contamination/attrition, app/bracing/review contexts, harms and unread materials. Preserve original numbers only; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or device/app recommendations/exercise/rehabilitation/recurrence-prevention/treatment-replacement instructions. - Remaining uncertainty: External original materials remain unread and existing content review is incomplete. Original grades/scores/axes and historical verification/independence descriptions are not upgraded to new verdicts/certification. - Referenced methods: Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production - Related sources: R01 ### N17 · Are original randomization/prespecified-endpoint descriptions preserved? Verification status: Partly verified Reading scope: Preserved summary read; external abstracts/full texts/registrations/protocols/SAP remain unread - Current findings: The original records independent-researcher computer allocation, impossible participant masking/masked adjudication, ITT, and matching prespecified self-reported recurrence primary endpoint/ISRCTN34177180. Preserve original quotations/history only; no plan/procedure comparison now. - Why unverified: Production observation distinguishing selected/parent, identified reports/reference contexts and comparison/endpoint materials in the preserved summary. Detailed originals remain unverified and existing content review incomplete; this does not establish passed review/clinical certification. - Reason for missing information: Allocation concealment/implementation, plans/amendments, registration versions/public dates and original-report comparison. The unestablished first registration publication date does not newly establish prospective registration. - Required materials and conditions: Independent-researcher computer allocation and recurrence primary endpoint/registration - Materials to obtain first: Allocation concealment/implementation, plans/amendments, registration versions/public dates and original-report comparison. The unestablished first registration publication date does not newly establish prospective registration. - Further research: Materials needed: Allocation concealment/implementation, plans/amendments, registration versions/public dates and original-report comparison. The unestablished first registration publication date does not newly establish prospective registration. Only material-request/research needs are recorded; no search/research was performed in this production. - Conditions for verification: Show original materials for independent-researcher computer allocation and recurrence primary endpoint/registration together with selected-subclaim/parent boundaries, direct endpoints/estimands, denominators/exposure and the scope of external reading. - Why this condition is needed: Needed to connect independent-researcher computer allocation and recurrence primary endpoint/registration with the selected question, actual population/intervention/comparator, endpoints/time points/estimands, denominators/repetition/exposure and reports/harms. - Application exceptions: Distinguish 2BFit’s actual post-sprain population, board/sheets/DVD/web support, usual care, eight weeks/one year, self-report/adjudication, people/ankles/events/exposure time, RR/CI/NNT, adherence/contamination/attrition, app/bracing/review contexts, harms and unread materials. Preserve original numbers only; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or device/app recommendations/exercise/rehabilitation/recurrence-prevention/treatment-replacement instructions. - Remaining uncertainty: External original materials remain unread and existing content review is incomplete. Original grades/scores/axes and historical verification/independence descriptions are not upgraded to new verdicts/certification. - Referenced methods: Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production - Related sources: R01 ### N18 · Are 2023 app results mixed with 2BFit? Verification status: Partly verified Reading scope: Preserved summary read; external abstracts/full texts/registrations/protocols/SAP remain unread - Current findings: The original counterview records a primary-care app trial with 165 participants, null HR 1.14 (0.59–2.21), adherence 6.1%. Preserve the original scope that delivery differed from 2BFit supplying a board/DVD and was not counted as direct conflict. Citation/design details remain unidentified. - Why unverified: Production observation distinguishing selected/parent, identified reports/reference contexts and comparison/endpoint materials in the preserved summary. Detailed originals remain unverified and existing content review incomplete; this does not establish passed review/clinical certification. - Reason for missing information: Exact app citations/registration, population/comparator/duration, endpoints/denominators/exposure/adherence, models and direct comparisons. Do not substitute app HR for board RR or effects of all apps. - Required materials and conditions: Different-delivery trial, 165 participants, HR 1.14 - Materials to obtain first: Exact app citations/registration, population/comparator/duration, endpoints/denominators/exposure/adherence, models and direct comparisons. Do not substitute app HR for board RR or effects of all apps. - Further research: Materials needed: Exact app citations/registration, population/comparator/duration, endpoints/denominators/exposure/adherence, models and direct comparisons. Do not substitute app HR for board RR or effects of all apps. Only material-request/research needs are recorded; no search/research was performed in this production. - Conditions for verification: Show original materials for different-delivery trial, 165 participants, HR 1.14 together with selected-subclaim/parent boundaries, direct endpoints/estimands, denominators/exposure and the scope of external reading. - Why this condition is needed: Needed to connect different-delivery trial, 165 participants, HR 1.14 with the selected question, actual population/intervention/comparator, endpoints/time points/estimands, denominators/repetition/exposure and reports/harms. - Application exceptions: Distinguish 2BFit’s actual post-sprain population, board/sheets/DVD/web support, usual care, eight weeks/one year, self-report/adjudication, people/ankles/events/exposure time, RR/CI/NNT, adherence/contamination/attrition, app/bracing/review contexts, harms and unread materials. Preserve original numbers only; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or device/app recommendations/exercise/rehabilitation/recurrence-prevention/treatment-replacement instructions. - Remaining uncertainty: External original materials remain unread and existing content review is incomplete. Original grades/scores/axes and historical verification/independence descriptions are not upgraded to new verdicts/certification. - Referenced methods: Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production - Related sources: R01, R02 ### N19 · Are different bracing-trial/review results separated? Verification status: Partly verified Reading scope: Preserved summary read; external abstracts/full texts/registrations/protocols/SAP remain unread - Current findings: The original records 12-month bracing superior to eight-week training in the 2014 trial and no 12-month recurrence difference between training/bracing in a 2017 review. Populations, citations, denominators, effects and CI for both contexts remain unverified; no difference does not become equivalence. - Why unverified: Production observation distinguishing selected/parent, identified reports/reference contexts and comparison/endpoint materials in the preserved summary. Detailed originals remain unverified and existing content review incomplete; this does not establish passed review/clinical certification. - Reason for missing information: Each citation, original trials/review-included studies/overlap, exact comparators/durations and effects/CI/denominators. Do not count different research as new pooled effects/unique trial totals. - Required materials and conditions: 2014 bracing superiority and no difference in 2017 - Materials to obtain first: Each citation, original trials/review-included studies/overlap, exact comparators/durations and effects/CI/denominators. Do not count different research as new pooled effects/unique trial totals. - Further research: Materials needed: Each citation, original trials/review-included studies/overlap, exact comparators/durations and effects/CI/denominators. Do not count different research as new pooled effects/unique trial totals. Only material-request/research needs are recorded; no search/research was performed in this production. - Conditions for verification: Show original materials for 2014 bracing superiority and no difference in 2017 together with selected-subclaim/parent boundaries, direct endpoints/estimands, denominators/exposure and the scope of external reading. - Why this condition is needed: Needed to connect 2014 bracing superiority and no difference in 2017 with the selected question, actual population/intervention/comparator, endpoints/time points/estimands, denominators/repetition/exposure and reports/harms. - Application exceptions: Distinguish 2BFit’s actual post-sprain population, board/sheets/DVD/web support, usual care, eight weeks/one year, self-report/adjudication, people/ankles/events/exposure time, RR/CI/NNT, adherence/contamination/attrition, app/bracing/review contexts, harms and unread materials. Preserve original numbers only; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or device/app recommendations/exercise/rehabilitation/recurrence-prevention/treatment-replacement instructions. - Remaining uncertainty: External original materials remain unread and existing content review is incomplete. Original grades/scores/axes and historical verification/independence descriptions are not upgraded to new verdicts/certification. - Referenced methods: Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production - Related sources: R03, R04 ### N20 · Is the separate exercise-harm reporting gap retained? Verification status: Unverified Reading scope: Preserved summary read; external abstracts/full texts/registrations/protocols/SAP remain unread - Current findings: The original safety description records that exercise-related adverse events were not collected/reported in a separate table and this trial cannot establish harmlessness. Preserve this reporting limitation; do not extend to zero AE or long-term safety. - Why unverified: Production observation distinguishing selected/parent, identified reports/reference contexts and comparison/endpoint materials in the preserved summary. Detailed originals remain unverified and existing content review incomplete; this does not establish passed review/clinical certification. - Reason for missing information: Harm collection/definitions, arm actual training/exposure, events/discontinuation/relatedness/denominators and long-term data. No exercise/rehabilitation/recurrence-prevention instructions. - Required materials and conditions: Exercise-related AE collection/reporting versus harmlessness - Materials to obtain first: Harm collection/definitions, arm actual training/exposure, events/discontinuation/relatedness/denominators and long-term data. No exercise/rehabilitation/recurrence-prevention instructions. - Further research: Materials needed: Harm collection/definitions, arm actual training/exposure, events/discontinuation/relatedness/denominators and long-term data. No exercise/rehabilitation/recurrence-prevention instructions. Only material-request/research needs are recorded; no search/research was performed in this production. - Conditions for verification: Show original materials for exercise-related AE collection/reporting versus harmlessness together with selected-subclaim/parent boundaries, direct endpoints/estimands, denominators/exposure and the scope of external reading. - Why this condition is needed: Needed to connect exercise-related AE collection/reporting versus harmlessness with the selected question, actual population/intervention/comparator, endpoints/time points/estimands, denominators/repetition/exposure and reports/harms. - Application exceptions: Distinguish 2BFit’s actual post-sprain population, board/sheets/DVD/web support, usual care, eight weeks/one year, self-report/adjudication, people/ankles/events/exposure time, RR/CI/NNT, adherence/contamination/attrition, app/bracing/review contexts, harms and unread materials. Preserve original numbers only; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or device/app recommendations/exercise/rehabilitation/recurrence-prevention/treatment-replacement instructions. - Remaining uncertainty: External original materials remain unread and existing content review is incomplete. Original grades/scores/axes and historical verification/independence descriptions are not upgraded to new verdicts/certification. - Referenced methods: Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production - Related sources: R01 ### N21 · What was actually read/identified? Verification status: Partly verified Reading scope: Preserved summary read; external abstracts/full texts/registrations/protocols/SAP remain unread - Current findings: The complete preserved parent summary was read for production and retained in the original archive. The single citation identifies 2BFit; three app/bracing/review entries are unidentified counterview contexts. All external abstracts/full texts/registration/plans remain unread. - Why unverified: Production observation distinguishing selected/parent, identified reports/reference contexts and comparison/endpoint materials in the preserved summary. Detailed originals remain unverified and existing content review incomplete; this does not establish passed review/clinical certification. - Reason for missing information: Exact report citations/originals, acquisition/reading scope, versions/dates. URLs/historical quotations are not upgraded to current reading; no external-link/access testing. - Required materials and conditions: Preserved summary/original citation versus unidentified reference contexts - Materials to obtain first: Exact report citations/originals, acquisition/reading scope, versions/dates. URLs/historical quotations are not upgraded to current reading; no external-link/access testing. - Further research: Materials needed: Exact report citations/originals, acquisition/reading scope, versions/dates. URLs/historical quotations are not upgraded to current reading; no external-link/access testing. Only material-request/research needs are recorded; no search/research was performed in this production. - Conditions for verification: Show original materials for preserved summary/original citation versus unidentified reference contexts together with selected-subclaim/parent boundaries, direct endpoints/estimands, denominators/exposure and the scope of external reading. - Why this condition is needed: Needed to connect preserved summary/original citation versus unidentified reference contexts with the selected question, actual population/intervention/comparator, endpoints/time points/estimands, denominators/repetition/exposure and reports/harms. - Application exceptions: Distinguish 2BFit’s actual post-sprain population, board/sheets/DVD/web support, usual care, eight weeks/one year, self-report/adjudication, people/ankles/events/exposure time, RR/CI/NNT, adherence/contamination/attrition, app/bracing/review contexts, harms and unread materials. Preserve original numbers only; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or device/app recommendations/exercise/rehabilitation/recurrence-prevention/treatment-replacement instructions. - Remaining uncertainty: External original materials remain unread and existing content review is incomplete. Original grades/scores/axes and historical verification/independence descriptions are not upgraded to new verdicts/certification. - Referenced methods: Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production - Related sources: R01, R02, R03, R04 ### N22 · Are registration dates/prespecification treated as current certification? Verification status: Partly verified Reading scope: Preserved summary read; external abstracts/full texts/registrations/protocols/SAP remain unread - Current findings: Original evidence/Korean text describes matching ISRCTN34177180 with the self-reported recurrence primary endpoint. Original study facts say the first registration public date was unestablished, so prospective registration was not asserted. App/bracing/review registrations are unidentified. - Why unverified: Production observation distinguishing selected/parent, identified reports/reference contexts and comparison/endpoint materials in the preserved summary. Detailed originals remain unverified and existing content review incomplete; this does not establish passed review/clinical certification. - Reason for missing information: Actual registration versions/publication, start/amendment timing and endpoints/plans. No guessed official URLs, new registration reading or prespecification certification. - Required materials and conditions: ISRCTN34177180 and unestablished first public date - Materials to obtain first: Actual registration versions/publication, start/amendment timing and endpoints/plans. No guessed official URLs, new registration reading or prespecification certification. - Further research: Materials needed: Actual registration versions/publication, start/amendment timing and endpoints/plans. No guessed official URLs, new registration reading or prespecification certification. Only material-request/research needs are recorded; no search/research was performed in this production. - Conditions for verification: Show original materials for iSRCTN34177180 and unestablished first public date together with selected-subclaim/parent boundaries, direct endpoints/estimands, denominators/exposure and the scope of external reading. - Why this condition is needed: Needed to connect iSRCTN34177180 and unestablished first public date with the selected question, actual population/intervention/comparator, endpoints/time points/estimands, denominators/repetition/exposure and reports/harms. - Application exceptions: Distinguish 2BFit’s actual post-sprain population, board/sheets/DVD/web support, usual care, eight weeks/one year, self-report/adjudication, people/ankles/events/exposure time, RR/CI/NNT, adherence/contamination/attrition, app/bracing/review contexts, harms and unread materials. Preserve original numbers only; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or device/app recommendations/exercise/rehabilitation/recurrence-prevention/treatment-replacement instructions. - Remaining uncertainty: External original materials remain unread and existing content review is incomplete. Original grades/scores/axes and historical verification/independence descriptions are not upgraded to new verdicts/certification. - Referenced methods: Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production - Related sources: R01, R02, R03, R04 ### N23 · Were protocol/SAP and estimand/missingness plans acquired? Verification status: Unverified Reading scope: Preserved summary read; external abstracts/full texts/registrations/protocols/SAP remain unread - Current findings: Preserve original primary/ITT/allocation/adjudication descriptions and historical cross-checking. Each trial’s protocol/SAP, versions/timing and missingness/multiplicity/analysis plans were not acquired/read now. - Why unverified: Production observation distinguishing selected/parent, identified reports/reference contexts and comparison/endpoint materials in the preserved summary. Detailed originals remain unverified and existing content review incomplete; this does not establish passed review/clinical certification. - Reason for missing information: Original protocols/SAP, amendment histories, endpoints/models/people/events/exposure, missingness/sensitivity and public timing. Unread external materials do not establish document absence. - Required materials and conditions: Separate prespecified-plan/analysis/amendment materials - Materials to obtain first: Original protocols/SAP, amendment histories, endpoints/models/people/events/exposure, missingness/sensitivity and public timing. Unread external materials do not establish document absence. - Further research: Materials needed: Original protocols/SAP, amendment histories, endpoints/models/people/events/exposure, missingness/sensitivity and public timing. Unread external materials do not establish document absence. Only material-request/research needs are recorded; no search/research was performed in this production. - Conditions for verification: Show original materials for separate prespecified-plan/analysis/amendment materials together with selected-subclaim/parent boundaries, direct endpoints/estimands, denominators/exposure and the scope of external reading. - Why this condition is needed: Needed to connect separate prespecified-plan/analysis/amendment materials with the selected question, actual population/intervention/comparator, endpoints/time points/estimands, denominators/repetition/exposure and reports/harms. - Application exceptions: Distinguish 2BFit’s actual post-sprain population, board/sheets/DVD/web support, usual care, eight weeks/one year, self-report/adjudication, people/ankles/events/exposure time, RR/CI/NNT, adherence/contamination/attrition, app/bracing/review contexts, harms and unread materials. Preserve original numbers only; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or device/app recommendations/exercise/rehabilitation/recurrence-prevention/treatment-replacement instructions. - Remaining uncertainty: External original materials remain unread and existing content review is incomplete. Original grades/scores/axes and historical verification/independence descriptions are not upgraded to new verdicts/certification. - Referenced methods: Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production - Related sources: R01, R02, R03, R04 ### N24 · Are public funding, board supply and company involvement separated? Verification status: Partly verified Reading scope: Preserved summary read; external abstracts/full texts/registrations/protocols/SAP remain unread - Current findings: 2BFit had ZonMw grant 750-20-002, declarations of no financial benefit/competing interests and Avanco AB boards supplied to participants. Preserve the original limitation that manufacturer donation/funding/analysis/writing/publication support was not reported. Supply is not manufacturer donation; employee authors/roles and app/bracing/review funding remain unverified now. - Why unverified: Production observation distinguishing selected/parent, identified reports/reference contexts and comparison/endpoint materials in the preserved summary. Detailed originals remain unverified and existing content review incomplete; this does not establish passed review/clinical certification. - Reason for missing information: Item-specific company funding, product support, employee authors, design/analysis/data control and other support for each study. I2 does not establish absence of every item or independence certification. - Required materials and conditions: 2BFit support versus unverified other contexts - Materials to obtain first: Item-specific company funding, product support, employee authors, design/analysis/data control and other support for each study. I2 does not establish absence of every item or independence certification. - Further research: Materials needed: Item-specific company funding, product support, employee authors, design/analysis/data control and other support for each study. I2 does not establish absence of every item or independence certification. Only material-request/research needs are recorded; no search/research was performed in this production. - Conditions for verification: Show original materials for 2BFit support versus unverified other contexts together with selected-subclaim/parent boundaries, direct endpoints/estimands, denominators/exposure and the scope of external reading. - Why this condition is needed: Needed to connect 2BFit support versus unverified other contexts with the selected question, actual population/intervention/comparator, endpoints/time points/estimands, denominators/repetition/exposure and reports/harms. - Application exceptions: Distinguish 2BFit’s actual post-sprain population, board/sheets/DVD/web support, usual care, eight weeks/one year, self-report/adjudication, people/ankles/events/exposure time, RR/CI/NNT, adherence/contamination/attrition, app/bracing/review contexts, harms and unread materials. Preserve original numbers only; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or device/app recommendations/exercise/rehabilitation/recurrence-prevention/treatment-replacement instructions. - Remaining uncertainty: External original materials remain unread and existing content review is incomplete. Original grades/scores/axes and historical verification/independence descriptions are not upgraded to new verdicts/certification. - Referenced methods: Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production - Related sources: R01, R02, R03, R04 ### N25 · Are specific positive effects, different-delivery null results and unverified details distinguished? Verification status: Partly verified Reading scope: Preserved summary read; external abstracts/full texts/registrations/protocols/SAP remain unread - Current findings: Positive 2BFit recurrence, null 2023 app HR, 2014 bracing superiority and no difference in the 2017 review concern different contexts. Separate original descriptions from unverified citation/effect/harm details; no new verdict on broad claims. - Why unverified: Production observation distinguishing selected/parent, identified reports/reference contexts and comparison/endpoint materials in the preserved summary. Detailed originals remain unverified and existing content review incomplete; this does not establish passed review/clinical certification. - Reason for missing information: Report-specific direct populations/interventions/comparators, endpoints/durations, effects/CI/denominators and actual access. Unread does not mean unreported; null does not mean zero effect/equivalence. - Required materials and conditions: Question/comparison-specific results and reading status - Materials to obtain first: Report-specific direct populations/interventions/comparators, endpoints/durations, effects/CI/denominators and actual access. Unread does not mean unreported; null does not mean zero effect/equivalence. - Further research: Materials needed: Report-specific direct populations/interventions/comparators, endpoints/durations, effects/CI/denominators and actual access. Unread does not mean unreported; null does not mean zero effect/equivalence. Only material-request/research needs are recorded; no search/research was performed in this production. - Conditions for verification: Show original materials for question/comparison-specific results and reading status together with selected-subclaim/parent boundaries, direct endpoints/estimands, denominators/exposure and the scope of external reading. - Why this condition is needed: Needed to connect question/comparison-specific results and reading status with the selected question, actual population/intervention/comparator, endpoints/time points/estimands, denominators/repetition/exposure and reports/harms. - Application exceptions: Distinguish 2BFit’s actual post-sprain population, board/sheets/DVD/web support, usual care, eight weeks/one year, self-report/adjudication, people/ankles/events/exposure time, RR/CI/NNT, adherence/contamination/attrition, app/bracing/review contexts, harms and unread materials. Preserve original numbers only; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or device/app recommendations/exercise/rehabilitation/recurrence-prevention/treatment-replacement instructions. - Remaining uncertainty: External original materials remain unread and existing content review is incomplete. Original grades/scores/axes and historical verification/independence descriptions are not upgraded to new verdicts/certification. - Referenced methods: Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production - Related sources: R01, R02, R03, R04 ### N26 · Are one original citation and three reference contexts counted as unique trials? Verification status: Partly verified Reading scope: Preserved summary read; external abstracts/full texts/registrations/protocols/SAP remain unread - Current findings: Parent 2975 and its s0/s1 claims share original 2BFit citation/trial context and counterview mentions of the 2023 app, 2014 bracing and 2017 review. The same people, ankles, arms, events, times, citations, related sheets and review-included trials are not newly added as independent trials/participants. Four links comprise one identified paper and three unidentified contexts, including a 2017 review; they are not certification of four unique clinical trials or participant totals. - Why unverified: Production observation distinguishing selected/parent, identified reports/reference contexts and comparison/endpoint materials in the preserved summary. Detailed originals remain unverified and existing content review incomplete; this does not establish passed review/clinical certification. - Reason for missing information: Citations/registration, review-included reports/overlap, cohorts/analysis, endpoints/repetition relationships. Unique trial/participant totals remain unrecorded. - Required materials and conditions: Document/context items versus trials/participants - Materials to obtain first: Citations/registration, review-included reports/overlap, cohorts/analysis, endpoints/repetition relationships. Unique trial/participant totals remain unrecorded. - Further research: Materials needed: Citations/registration, review-included reports/overlap, cohorts/analysis, endpoints/repetition relationships. Unique trial/participant totals remain unrecorded. Only material-request/research needs are recorded; no search/research was performed in this production. - Conditions for verification: Show original materials for document/context items versus trials/participants together with selected-subclaim/parent boundaries, direct endpoints/estimands, denominators/exposure and the scope of external reading. - Why this condition is needed: Needed to connect document/context items versus trials/participants with the selected question, actual population/intervention/comparator, endpoints/time points/estimands, denominators/repetition/exposure and reports/harms. - Application exceptions: Distinguish 2BFit’s actual post-sprain population, board/sheets/DVD/web support, usual care, eight weeks/one year, self-report/adjudication, people/ankles/events/exposure time, RR/CI/NNT, adherence/contamination/attrition, app/bracing/review contexts, harms and unread materials. Preserve original numbers only; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or device/app recommendations/exercise/rehabilitation/recurrence-prevention/treatment-replacement instructions. - Remaining uncertainty: External original materials remain unread and existing content review is incomplete. Original grades/scores/axes and historical verification/independence descriptions are not upgraded to new verdicts/certification. - Referenced methods: Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production - Related sources: R01, R02, R03, R04 ### N27 · Are original single confirmation and independent replication distinguished? Verification status: Unverified Reading scope: Preserved summary read; external abstracts/full texts/registrations/protocols/SAP remain unread - Current findings: Preserve parent replication R1/independence I2 and the original single confirmatory-trial description. App/bracing/review contexts are not counted as new same-condition independent replication/conflicts or unique-trial certification. - Why unverified: Production observation distinguishing selected/parent, identified reports/reference contexts and comparison/endpoint materials in the preserved summary. Detailed originals remain unverified and existing content review incomplete; this does not establish passed review/clinical certification. - Reason for missing information: Separate prespecified, direct population/delivery/comparator/events, effects/CI/denominators, funding/author relationships and overlap materials for the selected question. No search/independence determination now. - Required materials and conditions: Parent R1/I2 and comparison/delivery differences - Materials to obtain first: Separate prespecified, direct population/delivery/comparator/events, effects/CI/denominators, funding/author relationships and overlap materials for the selected question. No search/independence determination now. - Further research: Materials needed: Separate prespecified, direct population/delivery/comparator/events, effects/CI/denominators, funding/author relationships and overlap materials for the selected question. No search/independence determination now. Only material-request/research needs are recorded; no search/research was performed in this production. - Conditions for verification: Show original materials for parent R1/I2 and comparison/delivery differences together with selected-subclaim/parent boundaries, direct endpoints/estimands, denominators/exposure and the scope of external reading. - Why this condition is needed: Needed to connect parent R1/I2 and comparison/delivery differences with the selected question, actual population/intervention/comparator, endpoints/time points/estimands, denominators/repetition/exposure and reports/harms. - Application exceptions: Distinguish 2BFit’s actual post-sprain population, board/sheets/DVD/web support, usual care, eight weeks/one year, self-report/adjudication, people/ankles/events/exposure time, RR/CI/NNT, adherence/contamination/attrition, app/bracing/review contexts, harms and unread materials. Preserve original numbers only; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or device/app recommendations/exercise/rehabilitation/recurrence-prevention/treatment-replacement instructions. - Remaining uncertainty: External original materials remain unread and existing content review is incomplete. Original grades/scores/axes and historical verification/independence descriptions are not upgraded to new verdicts/certification. - Referenced methods: Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production - Related sources: R01, R02, R03, R04 ### N28 · Are the subclaim grade and parent score/axes preserved? Verification status: Partly verified Reading scope: Preserved summary read; external abstracts/full texts/registrations/protocols/SAP remain unread - Current findings: Preserve selected subclaim B/note/bilingual claims; absent subclaim score/status/axes remain unrecorded. Parent B with 76 points, unknown safety, B/H/R1/I2/E+/B0, unrecorded precision and true large-hard-endpoint RCT are parent context and do not fill subclaim values. - Why unverified: Production observation distinguishing selected/parent, identified reports/reference contexts and comparison/endpoint materials in the preserved summary. Detailed originals remain unverified and existing content review incomplete; this does not establish passed review/clinical certification. - Reason for missing information: User subclaim/parent-boundary review and actual correction materials. No new score/grade or official RoB 2/GRADE certification. - Required materials and conditions: Selected B, absent subclaim values and parent B76 - Materials to obtain first: User subclaim/parent-boundary review and actual correction materials. No new score/grade or official RoB 2/GRADE certification. - Further research: Materials needed: User subclaim/parent-boundary review and actual correction materials. No new score/grade or official RoB 2/GRADE certification. Only material-request/research needs are recorded; no search/research was performed in this production. - Conditions for verification: Show original materials for selected B, absent subclaim values and parent B76 together with selected-subclaim/parent boundaries, direct endpoints/estimands, denominators/exposure and the scope of external reading. - Why this condition is needed: Needed to connect selected B, absent subclaim values and parent B76 with the selected question, actual population/intervention/comparator, endpoints/time points/estimands, denominators/repetition/exposure and reports/harms. - Application exceptions: Distinguish 2BFit’s actual post-sprain population, board/sheets/DVD/web support, usual care, eight weeks/one year, self-report/adjudication, people/ankles/events/exposure time, RR/CI/NNT, adherence/contamination/attrition, app/bracing/review contexts, harms and unread materials. Preserve original numbers only; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or device/app recommendations/exercise/rehabilitation/recurrence-prevention/treatment-replacement instructions. - Remaining uncertainty: External original materials remain unread and existing content review is incomplete. Original grades/scores/axes and historical verification/independence descriptions are not upgraded to new verdicts/certification. - Referenced methods: Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production - Related sources: R01 ### N29 · Are both languages, citations and absent fields preserved? Verification status: Partly verified Reading scope: Preserved summary read; external abstracts/full texts/registrations/protocols/SAP remain unread - Current findings: Preserve original parent bilingual quotations/descriptions, evidence, citations and axes and selected-subclaim values in the complete original archive. Classification fields are absent and no new original fields are filled. No English-paper comparison now. - Why unverified: Production observation distinguishing selected/parent, identified reports/reference contexts and comparison/endpoint materials in the preserved summary. Detailed originals remain unverified and existing content review incomplete; this does not establish passed review/clinical certification. - Reason for missing information: User review of languages/terminology, event/exposure units, absences and selected scope. Distinguish production descriptions from original values. - Required materials and conditions: Both original languages and absent separate classification information - Materials to obtain first: User review of languages/terminology, event/exposure units, absences and selected scope. Distinguish production descriptions from original values. - Further research: Materials needed: User review of languages/terminology, event/exposure units, absences and selected scope. Distinguish production descriptions from original values. Only material-request/research needs are recorded; no search/research was performed in this production. - Conditions for verification: Show original materials for original bilingual text and absent classification fields together with selected-subclaim/parent boundaries, direct endpoints/estimands, denominators/exposure and the scope of external reading. - Why this condition is needed: Needed to connect original bilingual text and absent classification fields with the selected question, actual population/intervention/comparator, endpoints/time points/estimands, denominators/repetition/exposure and reports/harms. - Application exceptions: Distinguish 2BFit’s actual post-sprain population, board/sheets/DVD/web support, usual care, eight weeks/one year, self-report/adjudication, people/ankles/events/exposure time, RR/CI/NNT, adherence/contamination/attrition, app/bracing/review contexts, harms and unread materials. Preserve original numbers only; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or device/app recommendations/exercise/rehabilitation/recurrence-prevention/treatment-replacement instructions. - Remaining uncertainty: External original materials remain unread and existing content review is incomplete. Original grades/scores/axes and historical verification/independence descriptions are not upgraded to new verdicts/certification. - Referenced methods: Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production - Related sources: R01 ### N30 · Are source dates/corrections/history separated from production dates? Verification status: Partly verified Reading scope: Preserved summary read; external abstracts/full texts/registrations/protocols/SAP remain unread - Current findings: Preserve original evidence date 2026-08-26, empty corrections/deliberation and verdict-decision cross-checking. Historical quotations/registration matching differ from current production, condition freezing/application and completed content review. - Why unverified: Production observation distinguishing selected/parent, identified reports/reference contexts and comparison/endpoint materials in the preserved summary. Detailed originals remain unverified and existing content review incomplete; this does not establish passed review/clinical certification. - Reason for missing information: Update materials separating originals, events, conditions/observations and verdict decisions when new evidence/corrections arise. Historical wording is not completed clinical content review here. - Required materials and conditions: Original 2026-08-26 and new conditions/application - Materials to obtain first: Update materials separating originals, events, conditions/observations and verdict decisions when new evidence/corrections arise. Historical wording is not completed clinical content review here. - Further research: Materials needed: Update materials separating originals, events, conditions/observations and verdict decisions when new evidence/corrections arise. Historical wording is not completed clinical content review here. Only material requests/research needs are recorded; no search or research was performed in that production. - Conditions for verification: Show original materials for original 2026-08-26 versus new conditions/application together with selected-subclaim/parent boundaries, direct endpoints/estimands, denominators/exposure and the scope of external reading. - Why this condition is needed: Needed to connect original 2026-08-26 versus new conditions/application with the selected question, actual population/intervention/comparator, endpoints/time points/estimands, denominators/repetition/exposure and reports/harms. - Application exceptions: Distinguish 2BFit’s actual post-sprain population, board/sheets/DVD/web support, usual care, eight weeks/one year, self-report/adjudication, people/ankles/events/exposure time, RR/CI/NNT, adherence/contamination/attrition, app/bracing/review contexts, harms and unread materials. Preserve original numbers only; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or device/app recommendations/exercise/rehabilitation/recurrence-prevention/treatment-replacement instructions. - Remaining uncertainty: External original materials remain unread and existing content review is incomplete. Original grades/scores/axes and historical verification/independence descriptions are not upgraded to new verdicts/certification. - Referenced methods: Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production - Related sources: R01 ### N31 · What direct materials would fill the selected gaps? Verification status: Unverified Reading scope: Preserved summary read; external abstracts/full texts/registrations/protocols/SAP remain unread - Current findings: Specific 2BFit event/exposure, adherence/attrition, harms/reporting details require originals; app/bracing mentions do not substitute as identical effects. - Why unverified: Production observation distinguishing selected/parent, identified reports/reference contexts and comparison/endpoint materials in the preserved summary. Detailed originals remain unverified and existing content review incomplete; this does not establish passed review/clinical certification. - Reason for missing information: Question-specific tables/plans, direct comparisons/applicability, effects/CI, people/ankle/event/exposure denominators, missingness/adherence, separate confirmation and long-term harms. Need recorded only; no search/research now. - Required materials and conditions: Direct population/delivery/events, effects/CI and denominators - Materials to obtain first: Question-specific tables/plans, direct comparisons/applicability, effects/CI, people/ankle/event/exposure denominators, missingness/adherence, separate confirmation and long-term harms. Need recorded only; no search/research now. - Further research: Materials needed: Question-specific tables/plans, direct comparisons/applicability, effects/CI, people/ankle/event/exposure denominators, missingness/adherence, separate confirmation and long-term harms. Need recorded only; no search/research now. Only material-request/research needs are recorded; no search/research was performed in this production. - Conditions for verification: Show original materials for direct population/delivery/events, effects/CI and denominators together with selected-subclaim/parent boundaries, direct endpoints/estimands, denominators/exposure and the scope of external reading. - Why this condition is needed: Needed to connect direct population/delivery/events, effects/CI and denominators with the selected question, actual population/intervention/comparator, endpoints/time points/estimands, denominators/repetition/exposure and reports/harms. - Application exceptions: Distinguish 2BFit’s actual post-sprain population, board/sheets/DVD/web support, usual care, eight weeks/one year, self-report/adjudication, people/ankles/events/exposure time, RR/CI/NNT, adherence/contamination/attrition, app/bracing/review contexts, harms and unread materials. Preserve original numbers only; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or device/app recommendations/exercise/rehabilitation/recurrence-prevention/treatment-replacement instructions. - Remaining uncertainty: External original materials remain unread and existing content review is incomplete. Original grades/scores/axes and historical verification/independence descriptions are not upgraded to new verdicts/certification. - Referenced methods: Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production - Related sources: R01, R02, R03, R04 ### N32 · Are applicability records separated from content review and instructions? Verification status: Partly verified Reading scope: Preserved summary read; external abstracts/full texts/registrations/protocols/SAP remain unread - Current findings: These are summary-based applicability records. Existing content/question-boundary review remains incomplete; candidate pending/eligible markers are preserved as history. - Why unverified: Production observation distinguishing selected/parent, identified reports/reference contexts and comparison/endpoint materials in the preserved summary. Detailed originals remain unverified and existing content review incomplete; this does not establish passed review/clinical certification. - Reason for missing information: Content review and subsequent actual evidence/correction work. Original content-production scope excludes clinical QA/testing, external-link/access/web/API research, new calculations/grades and device/app recommendations or exercise/rehabilitation/prevention/treatment-replacement instructions. - Required materials and conditions: Applicability records, existing candidate history and content review - Materials to obtain first: Content review and subsequent actual evidence/correction work. Original content-production scope excludes clinical QA/testing, external-link/access/web/API research, new calculations/grades and device/app recommendations or exercise/rehabilitation/prevention/treatment-replacement instructions. - Further research: Materials needed: Content review and subsequent actual evidence/correction work. Original content-production scope excludes clinical QA/testing, external-link/access/web/API research, new calculations/grades and device/app recommendations or exercise/rehabilitation/prevention/treatment-replacement instructions. Only material-request/research needs are recorded; no search/research was performed in this production. - Conditions for verification: Show original materials for production request, candidate history and content review together with selected-subclaim/parent boundaries, direct endpoints/estimands, denominators/exposure and the scope of external reading. - Why this condition is needed: Needed to connect production request, candidate history and content review with the selected question, actual population/intervention/comparator, endpoints/time points/estimands, denominators/repetition/exposure and reports/harms. - Application exceptions: Distinguish 2BFit’s actual post-sprain population, board/sheets/DVD/web support, usual care, eight weeks/one year, self-report/adjudication, people/ankles/events/exposure time, RR/CI/NNT, adherence/contamination/attrition, app/bracing/review contexts, harms and unread materials. Preserve original numbers only; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or device/app recommendations/exercise/rehabilitation/recurrence-prevention/treatment-replacement instructions. - Remaining uncertainty: External original materials remain unread and existing content review is incomplete. Original grades/scores/axes and historical verification/independence descriptions are not upgraded to new verdicts/certification. - Referenced methods: Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production - Related sources: R01 ## Evidence and sources ### R01 Hupperets MDW, et al. Effect of unsupervised home based proprioceptive training on recurrences of ankle sprain. BMJ. 2009;339:b2684. PMID: 19589822. [PubMed](https://pubmed.ncbi.nlm.nih.gov/19589822/) Materials actually read: Preserved summary read; external abstracts/full texts/registrations/plans remain unread Findings recorded in the summary: 56/256 (22%) versus 89/266 (33%); adjusted RR 0.63 (0.45–0.88), NNT 9 Record level: 2BFit core-endpoint summary from the original evidence list, separated from other contexts Independent replication: The 2BFit core one-year same-ankle recurrence trial concerns a specific eight-week program combining a board and delivery support. The app context used different delivery and was not counted as direct conflict with 2BFit. Bracing versus training is a different comparison and is not repurposed as app effects/equal-duration comparison. The review context is not an independent clinical trial; no difference does not certify equivalence. Parent 2975 and its s0/s1 claims share the original 2BFit citation/trial context and counterview mentions of the 2023 app, 2014 bracing and 2017 review. The same people, ankles, arms, events, times, citations, related sheets and review-included trials are not newly added as independent trials/participants. These are provisional reference-context items; actual cohort/independence and review-included-study relationships remain incompletely reviewed. | Material | Public availability | Access status | Actually read | Notes | |---|---|---|---|---| | Stored summary | Local preserved copy of the complete parent summary | Stored summary read | Summary read | Only original PubMed URL/ISRCTN are preserved. Exact titles/authors/DOI/PMID/registration/URLs are not guessed for contexts without citations. No new external reading/access/verification certification. | | External abstract | Original identifier/bibliography or required-material entry; public availability/access details remain unverified | Unread; access testing not performed | Not read | Only original PubMed URL/ISRCTN are preserved. Exact titles/authors/DOI/PMID/registration/URLs are not guessed for contexts without citations. No new external reading/access/verification certification. | | External full text | Original identifier/bibliography or required-material entry; public availability/access details remain unverified | Unread; access testing not performed | Not read | Only original PubMed URL/ISRCTN are preserved. Exact titles/authors/DOI/PMID/registration/URLs are not guessed for contexts without citations. No new external reading/access/verification certification. | | Registration material | Original identifier/bibliography or required-material entry; public availability/access details remain unverified | Unread; access testing not performed | Not read | Only original PubMed URL/ISRCTN are preserved. Exact titles/authors/DOI/PMID/registration/URLs are not guessed for contexts without citations. No new external reading/access/verification certification. | | Protocol/SAP | Original identifier/bibliography or required-material entry; public availability/access details remain unverified | Unread; access testing not performed | Not read | Only original PubMed URL/ISRCTN are preserved. Exact titles/authors/DOI/PMID/registration/URLs are not guessed for contexts without citations. No new external reading/access/verification certification. | ### R02 2023 primary-care app trial — Unidentified reference context in the original counterview Materials actually read: Preserved summary read; external abstracts/full texts/registrations/plans remain unread Findings recorded in the summary: Original counterview: 165 participants, null HR 1.14 (0.59–2.21), adherence 6.1%. Exact citation/design/comparator/duration and denominator details remain unverified. Record level: Separate reference-context summary in the original counterview; no separate evidence/citation-list entry or exact citation Independent replication: The 2BFit core one-year same-ankle recurrence trial concerns a specific eight-week program combining a board and delivery support. The app context used different delivery and was not counted as direct conflict with 2BFit. Bracing versus training is a different comparison and is not repurposed as app effects/equal-duration comparison. The review context is not an independent clinical trial; no difference does not certify equivalence. Parent 2975 and its s0/s1 claims share the original 2BFit citation/trial context and counterview mentions of the 2023 app, 2014 bracing and 2017 review. The same people, ankles, arms, events, times, citations, related sheets and review-included trials are not newly added as independent trials/participants. These are provisional reference-context items; actual cohort/independence and review-included-study relationships remain incompletely reviewed. | Material | Public availability | Access status | Actually read | Notes | |---|---|---|---|---| | Stored summary | Local preserved copy of the complete parent summary | Stored summary read | Summary read | Only original PubMed URL/ISRCTN are preserved. Exact titles/authors/DOI/PMID/registration/URLs are not guessed for contexts without citations. No new external reading/access/verification certification. | | External abstract | Unidentified/unacquired material items | Unread; access testing not performed | Not read | Only original PubMed URL/ISRCTN are preserved. Exact titles/authors/DOI/PMID/registration/URLs are not guessed for contexts without citations. No new external reading/access/verification certification. | | External full text | Unidentified/unacquired material items | Unread; access testing not performed | Not read | Only original PubMed URL/ISRCTN are preserved. Exact titles/authors/DOI/PMID/registration/URLs are not guessed for contexts without citations. No new external reading/access/verification certification. | | Registration material | Unidentified/unacquired material items | Unread; access testing not performed | Not read | Only original PubMed URL/ISRCTN are preserved. Exact titles/authors/DOI/PMID/registration/URLs are not guessed for contexts without citations. No new external reading/access/verification certification. | | Protocol/SAP | Unidentified/unacquired material items | Unread; access testing not performed | Not read | Only original PubMed URL/ISRCTN are preserved. Exact titles/authors/DOI/PMID/registration/URLs are not guessed for contexts without citations. No new external reading/access/verification certification. | ### R03 2014 bracing comparison trial — Unidentified reference context in the original counterview Materials actually read: Preserved summary read; external abstracts/full texts/registrations/plans remain unread Findings recorded in the summary: Original counterview: 12-month bracing superior to eight-week training; exact effects/CI, population/denominators and citation remain unverified. Record level: Separate reference-context summary in the original counterview; no separate evidence/citation-list entry or exact citation Independent replication: The 2BFit core one-year same-ankle recurrence trial concerns a specific eight-week program combining a board and delivery support. The app context used different delivery and was not counted as direct conflict with 2BFit. Bracing versus training is a different comparison and is not repurposed as app effects/equal-duration comparison. The review context is not an independent clinical trial; no difference does not certify equivalence. Parent 2975 and its s0/s1 claims share the original 2BFit citation/trial context and counterview mentions of the 2023 app, 2014 bracing and 2017 review. The same people, ankles, arms, events, times, citations, related sheets and review-included trials are not newly added as independent trials/participants. These are provisional reference-context items; actual cohort/independence and review-included-study relationships remain incompletely reviewed. | Material | Public availability | Access status | Actually read | Notes | |---|---|---|---|---| | Stored summary | Local preserved copy of the complete parent summary | Stored summary read | Summary read | Only original PubMed URL/ISRCTN are preserved. Exact titles/authors/DOI/PMID/registration/URLs are not guessed for contexts without citations. No new external reading/access/verification certification. | | External abstract | Unidentified/unacquired material items | Unread; access testing not performed | Not read | Only original PubMed URL/ISRCTN are preserved. Exact titles/authors/DOI/PMID/registration/URLs are not guessed for contexts without citations. No new external reading/access/verification certification. | | External full text | Unidentified/unacquired material items | Unread; access testing not performed | Not read | Only original PubMed URL/ISRCTN are preserved. Exact titles/authors/DOI/PMID/registration/URLs are not guessed for contexts without citations. No new external reading/access/verification certification. | | Registration material | Unidentified/unacquired material items | Unread; access testing not performed | Not read | Only original PubMed URL/ISRCTN are preserved. Exact titles/authors/DOI/PMID/registration/URLs are not guessed for contexts without citations. No new external reading/access/verification certification. | | Protocol/SAP | Unidentified/unacquired material items | Unread; access testing not performed | Not read | Only original PubMed URL/ISRCTN are preserved. Exact titles/authors/DOI/PMID/registration/URLs are not guessed for contexts without citations. No new external reading/access/verification certification. | ### R04 2017 training/bracing review — Unidentified reference context in the original counterview Materials actually read: Preserved summary read; external abstracts/full texts/registrations/plans remain unread Findings recorded in the summary: Original counterview: no 12-month recurrence difference found between training/bracing; original review/included trials/effects/CI remain unverified. Record level: Separate reference-context summary in the original counterview; no separate evidence/citation-list entry or exact citation Independent replication: The 2BFit core one-year same-ankle recurrence trial concerns a specific eight-week program combining a board and delivery support. The app context used different delivery and was not counted as direct conflict with 2BFit. Bracing versus training is a different comparison and is not repurposed as app effects/equal-duration comparison. The review context is not an independent clinical trial; no difference does not certify equivalence. Parent 2975 and its s0/s1 claims share the original 2BFit citation/trial context and counterview mentions of the 2023 app, 2014 bracing and 2017 review. The same people, ankles, arms, events, times, citations, related sheets and review-included trials are not newly added as independent trials/participants. These are provisional reference-context items; actual cohort/independence and review-included-study relationships remain incompletely reviewed. | Material | Public availability | Access status | Actually read | Notes | |---|---|---|---|---| | Stored summary | Local preserved copy of the complete parent summary | Stored summary read | Summary read | Only original PubMed URL/ISRCTN are preserved. Exact titles/authors/DOI/PMID/registration/URLs are not guessed for contexts without citations. No new external reading/access/verification certification. | | External abstract | Unidentified/unacquired material items | Unread; access testing not performed | Not read | Only original PubMed URL/ISRCTN are preserved. Exact titles/authors/DOI/PMID/registration/URLs are not guessed for contexts without citations. No new external reading/access/verification certification. | | External full text | Unidentified/unacquired material items | Unread; access testing not performed | Not read | Only original PubMed URL/ISRCTN are preserved. Exact titles/authors/DOI/PMID/registration/URLs are not guessed for contexts without citations. No new external reading/access/verification certification. | | Registration material | Unidentified/unacquired material items | Unread; access testing not performed | Not read | Only original PubMed URL/ISRCTN are preserved. Exact titles/authors/DOI/PMID/registration/URLs are not guessed for contexts without citations. No new external reading/access/verification certification. | | Protocol/SAP | Unidentified/unacquired material items | Unread; access testing not performed | Not read | Only original PubMed URL/ISRCTN are preserved. Exact titles/authors/DOI/PMID/registration/URLs are not guessed for contexts without citations. No new external reading/access/verification certification. | ## Review criteria and methods These are Chamgap's own application conditions, informed by the relevant sections of official methodological guidance. They do not constitute official assessment-tool certification or a new efficacy score. - M03 [Cochrane Handbook 6.5 (2024), chapter updated 2023-08](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03) · §3.1, §3.2.1–3.2.3, MECIR C5/C7/C13 · Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions. · Link preserved methodological application records; no current clinical-content reassessment or external-link verification was performed. - M04 [Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04) · §4.5, §4.6.1–4.6.3, MECIR C42 · Distinguish studies from reports and link them; do not omit a study solely because results are unreported. · Link preserved methodological application records; no current clinical-content reassessment or external-link verification was performed. - M08 [Cochrane Handbook 6.5 (2024), chapter updated 2019-10](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08) · §8.1–8.2.3, Table 8.2.a · Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting. · Link preserved methodological application records; no current clinical-content reassessment or external-link verification was performed. - M15 [Cochrane Handbook 6.5 (2024), chapter updated 2023-08](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15) · §15.2.4, §15.3.1–15.3.3 · Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision. · Link preserved methodological application records; no current clinical-content reassessment or external-link verification was performed. - M19 [Cochrane Handbook 6.5 (2024), chapter updated 2019-10](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19) · §19.1.2, §19.2.1–19.2.4 · Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates. · Link preserved methodological application records; no current clinical-content reassessment or external-link verification was performed. ## What the statuses mean - Partly verified: Some information exists in the preserved review summary; detailed original materials remain unverified. This does not certify a passed review or clinical efficacy. - Unverified: Detailed materials for the selected condition could not be established within the stored scope; this does not mean zero effect, zero studies or safety - Review incomplete: Review of existing content incomplete - Met: Use only within the relevant conditions after existing content review; no automatic designation in this preparation - Not reported: Distinguish only within materials actually read; do not turn unread external materials into unreported findings - Inaccessible: Not applied during this preparation because actual access was not tested - Not applicable: Use with a reason for non-applicability based on an explicit question boundary - Conflicting data: Judge after actual material comparison; review was not performed during this preparation - Insufficient evidence for the conditions: Do not use as a clinical grade encompassing currently unread materials ## Change history 2026-10-14 · Public page/materials 1.0. Public pages and materials were prepared from the existing 32 items. No new clinical search, verification-status change or scoring was performed.