{
  "schema_version": "chamgap-public-criteria-1.0",
  "title": "Penicillin V × Protection after stopping — Time intervals, 27% recurrence and gaps",
  "language": "en",
  "translation_date": "2026-10-14",
  "criteria_version": "1.0",
  "criteria_date": "2026-10-06",
  "condition_origin": "Chamgap's own application conditions",
  "method_sources": [
    {
      "id": "M03",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03",
      "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13",
      "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.",
      "review_level": "Link preserved methodological application records; no current clinical-content reassessment or external-link verification was performed."
    },
    {
      "id": "M04",
      "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04",
      "section": "§4.5, §4.6.1–4.6.3, MECIR C42",
      "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.",
      "review_level": "Link preserved methodological application records; no current clinical-content reassessment or external-link verification was performed."
    },
    {
      "id": "M08",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08",
      "section": "§8.1–8.2.3, Table 8.2.a",
      "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.",
      "review_level": "Link preserved methodological application records; no current clinical-content reassessment or external-link verification was performed."
    },
    {
      "id": "M15",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15",
      "section": "§15.2.4, §15.3.1–15.3.3",
      "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.",
      "review_level": "Link preserved methodological application records; no current clinical-content reassessment or external-link verification was performed."
    },
    {
      "id": "M19",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19",
      "section": "§19.1.2, §19.2.1–19.2.4",
      "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.",
      "review_level": "Link preserved methodological application records; no current clinical-content reassessment or external-link verification was performed."
    }
  ],
  "status_dictionary": {
    "Partly verified": "Some information exists in the preserved review summary; detailed original materials remain unverified. This does not certify a passed review or clinical efficacy.",
    "Unverified": "Detailed materials for the selected condition could not be established within the stored scope; this does not mean zero effect, zero studies or safety",
    "Review incomplete": "Review of existing content incomplete",
    "Met": "Use only within the relevant conditions after existing content review; no automatic designation in this preparation",
    "Not reported": "Distinguish only within materials actually read; do not turn unread external materials into unreported findings",
    "Inaccessible": "Not applied during this preparation because actual access was not tested",
    "Not applicable": "Use with a reason for non-applicability based on an explicit question boundary",
    "Conflicting data": "Judge after actual material comparison; review was not performed during this preparation",
    "Insufficient evidence for the conditions": "Do not use as a clinical grade encompassing currently unread materials"
  },
  "requirements": [
    {
      "item_id": "N01",
      "question_type": "Evidence condition",
      "question": "Which original post-treatment protection claim is selected?",
      "needed": "Selected wording/subclaim grade and parent effects during treatment",
      "role": "Required",
      "role_reason": "Needed to connect selected wording/subclaim grade and parent effects during treatment with the selected question, actual population/intervention/comparator, intervals/endpoints/estimands, denominators/repetition/exposure and reports/harms.",
      "application_exception": "Distinguish during/post-treatment intervals, first/repeated clinician-confirmed recurrence, people/time denominators/censoring, adherence/withdrawal/follow-up, HR/NNT/CI and post-treatment 27%, the separate PATCH II cohort, harms and applicability. Only original numbers are preserved; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or antibiotic/product-use/cellulitis-management/infection-prevention/treatment-replacement instructions.",
      "criterion": "Show original materials for selected wording/subclaim grade and parent effects during treatment together with selected-subclaim/parent boundaries, direct intervals/endpoints/estimands/denominators and the scope of external reading.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Definitions, start/duration, denominators/estimands for post-treatment follow-up and review of the claim boundary. Parent scores do not fill the subclaim score. Only material-request/research needs are recorded; no search/research was performed in this production."
    },
    {
      "item_id": "N02",
      "question_type": "Evidence condition",
      "question": "Which recurrence-history population was studied?",
      "needed": "Adults with at least two leg-cellulitis episodes in the previous three years",
      "role": "Required",
      "role_reason": "Needed to connect adults with at least two leg-cellulitis episodes in the previous three years with the selected question, actual population/intervention/comparator, intervals/endpoints/estimands, denominators/repetition/exposure and reports/harms.",
      "application_exception": "Distinguish during/post-treatment intervals, first/repeated clinician-confirmed recurrence, people/time denominators/censoring, adherence/withdrawal/follow-up, HR/NNT/CI and post-treatment 27%, the separate PATCH II cohort, harms and applicability. Only original numbers are preserved; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or antibiotic/product-use/cellulitis-management/infection-prevention/treatment-replacement instructions.",
      "criterion": "Show original materials for adults with at least two leg-cellulitis episodes in the previous three years together with selected-subclaim/parent boundaries, direct intervals/endpoints/estimands/denominators and the scope of external reading.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Eligibility/exclusions, baseline history/severity, oedema/skin/comorbidities, treatment/follow-up and direct comparisons in other populations. Only material-request/research needs are recorded; no search/research was performed in this production."
    },
    {
      "item_id": "N03",
      "question_type": "Evidence condition",
      "question": "Are study exposure and the post-treatment interval separated?",
      "needed": "Penicillin V 250 mg twice daily for 12 months",
      "role": "Required",
      "role_reason": "Needed to connect penicillin V 250 mg twice daily for 12 months with the selected question, actual population/intervention/comparator, intervals/endpoints/estimands, denominators/repetition/exposure and reports/harms.",
      "application_exception": "Distinguish during/post-treatment intervals, first/repeated clinician-confirmed recurrence, people/time denominators/censoring, adherence/withdrawal/follow-up, HR/NNT/CI and post-treatment 27%, the separate PATCH II cohort, harms and applicability. Only original numbers are preserved; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or antibiotic/product-use/cellulitis-management/infection-prevention/treatment-replacement instructions.",
      "criterion": "Show original materials for penicillin V 250 mg twice daily for 12 months together with selected-subclaim/parent boundaries, direct intervals/endpoints/estimands/denominators and the scope of external reading.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Original actual-exposure/adherence, discontinuation dates/reasons, concurrent treatment and follow-up time data. No drug/cellulitis-management or treatment-replacement instructions. Only material-request/research needs are recorded; no search/research was performed in this production."
    },
    {
      "item_id": "N04",
      "question_type": "Evidence condition",
      "question": "Is the scope of actual comparison/concurrent care known?",
      "needed": "Placebo comparison and post-treatment care",
      "role": "Required",
      "role_reason": "Needed to connect placebo comparison and post-treatment care with the selected question, actual population/intervention/comparator, intervals/endpoints/estimands, denominators/repetition/exposure and reports/harms.",
      "application_exception": "Distinguish during/post-treatment intervals, first/repeated clinician-confirmed recurrence, people/time denominators/censoring, adherence/withdrawal/follow-up, HR/NNT/CI and post-treatment 27%, the separate PATCH II cohort, harms and applicability. Only original numbers are preserved; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or antibiotic/product-use/cellulitis-management/infection-prevention/treatment-replacement instructions.",
      "criterion": "Show original materials for placebo comparison and post-treatment care together with selected-subclaim/parent boundaries, direct intervals/endpoints/estimands/denominators and the scope of external reading.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Actual placebo/care in both arms, treatment completion/withdrawal, post-treatment care/exposure and observation data. Do not repurpose as comparisons of other doses/injections/procedures. Only material-request/research needs are recorded; no search/research was performed in this production."
    },
    {
      "item_id": "N05",
      "question_type": "Evidence condition",
      "question": "What is the direct post-treatment protection result?",
      "needed": "27% in both arms during off-treatment follow-up",
      "role": "Required",
      "role_reason": "Needed to connect 27% in both arms during off-treatment follow-up with the selected question, actual population/intervention/comparator, intervals/endpoints/estimands, denominators/repetition/exposure and reports/harms.",
      "application_exception": "Distinguish during/post-treatment intervals, first/repeated clinician-confirmed recurrence, people/time denominators/censoring, adherence/withdrawal/follow-up, HR/NNT/CI and post-treatment 27%, the separate PATCH II cohort, harms and applicability. Only original numbers are preserved; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or antibiotic/product-use/cellulitis-management/infection-prevention/treatment-replacement instructions.",
      "criterion": "Show original materials for 27% in both arms during off-treatment follow-up together with selected-subclaim/parent boundaries, direct intervals/endpoints/estimands/denominators and the scope of external reading.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Arm-specific post-treatment numerators/denominators, estimands/CI, event/follow-up definitions, observation start/end and original tables. Do not back-calculate new event counts/HR/RR from 27%. Only material-request/research needs are recorded; no search/research was performed in this production."
    },
    {
      "item_id": "N06",
      "question_type": "Evidence condition",
      "question": "Which interval do the during-treatment numbers concern?",
      "needed": "30/136 versus 51/138, HR/CI/P and NNT",
      "role": "Required",
      "role_reason": "Needed to connect 30/136 versus 51/138, HR/CI/P and NNT with the selected question, actual population/intervention/comparator, intervals/endpoints/estimands, denominators/repetition/exposure and reports/harms.",
      "application_exception": "Distinguish during/post-treatment intervals, first/repeated clinician-confirmed recurrence, people/time denominators/censoring, adherence/withdrawal/follow-up, HR/NNT/CI and post-treatment 27%, the separate PATCH II cohort, harms and applicability. Only original numbers are preserved; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or antibiotic/product-use/cellulitis-management/infection-prevention/treatment-replacement instructions.",
      "criterion": "Show original materials for 30/136 versus 51/138, HR/CI/P and NNT together with selected-subclaim/parent boundaries, direct intervals/endpoints/estimands/denominators and the scope of external reading.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Interval-specific estimands, denominators/censoring, models/plans and post-treatment effects/CI. No new absolute difference/RRR/NNT/CI calculations. Only material-request/research needs are recorded; no search/research was performed in this production."
    },
    {
      "item_id": "N07",
      "question_type": "Evidence condition",
      "question": "Are observation starts and lengths during/after treatment verified?",
      "needed": "Time intervals and the post-treatment follow-up-duration gap",
      "role": "Required",
      "role_reason": "Needed to connect time intervals and the post-treatment follow-up-duration gap with the selected question, actual population/intervention/comparator, intervals/endpoints/estimands, denominators/repetition/exposure and reports/harms.",
      "application_exception": "Distinguish during/post-treatment intervals, first/repeated clinician-confirmed recurrence, people/time denominators/censoring, adherence/withdrawal/follow-up, HR/NNT/CI and post-treatment 27%, the separate PATCH II cohort, harms and applicability. Only original numbers are preserved; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or antibiotic/product-use/cellulitis-management/infection-prevention/treatment-replacement instructions.",
      "criterion": "Show original materials for time intervals and the post-treatment follow-up-duration gap together with selected-subclaim/parent boundaries, direct intervals/endpoints/estimands/denominators and the scope of external reading.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Interval-specific observation plans, treatment end/follow-up start, censoring/withdrawal, actual exposure/event-time originals. Do not mix post-treatment cumulative and time-specific risks. Only material-request/research needs are recorded; no search/research was performed in this production."
    },
    {
      "item_id": "N08",
      "question_type": "Evidence condition",
      "question": "What is the risk population underlying post-treatment 27%?",
      "needed": "274 randomized participants and interval-specific denominators",
      "role": "Required",
      "role_reason": "Needed to connect 274 randomized participants and interval-specific denominators with the selected question, actual population/intervention/comparator, intervals/endpoints/estimands, denominators/repetition/exposure and reports/harms.",
      "application_exception": "Distinguish during/post-treatment intervals, first/repeated clinician-confirmed recurrence, people/time denominators/censoring, adherence/withdrawal/follow-up, HR/NNT/CI and post-treatment 27%, the separate PATCH II cohort, harms and applicability. Only original numbers are preserved; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or antibiotic/product-use/cellulitis-management/infection-prevention/treatment-replacement instructions.",
      "criterion": "Show original materials for 274 randomized participants and interval-specific denominators together with selected-subclaim/parent boundaries, direct intervals/endpoints/estimands/denominators and the scope of external reading.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Interval-specific risk sets/denominators, events/censoring, flow/follow-up loss and analysis data. No new post-treatment events/rates or participant addition. Only material-request/research needs are recorded; no search/research was performed in this production."
    },
    {
      "item_id": "N09",
      "question_type": "Evidence condition",
      "question": "Are first recurrence and all repeated events distinguished?",
      "needed": "Time to first clinician-confirmed leg recurrence",
      "role": "Required",
      "role_reason": "Needed to connect time to first clinician-confirmed leg recurrence with the selected question, actual population/intervention/comparator, intervals/endpoints/estimands, denominators/repetition/exposure and reports/harms.",
      "application_exception": "Distinguish during/post-treatment intervals, first/repeated clinician-confirmed recurrence, people/time denominators/censoring, adherence/withdrawal/follow-up, HR/NNT/CI and post-treatment 27%, the separate PATCH II cohort, harms and applicability. Only original numbers are preserved; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or antibiotic/product-use/cellulitis-management/infection-prevention/treatment-replacement instructions.",
      "criterion": "Show original materials for time to first clinician-confirmed leg recurrence together with selected-subclaim/parent boundaries, direct intervals/endpoints/estimands/denominators and the scope of external reading.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Original interval-specific event definitions, first/repeated aggregation, person/leg identifiers, post-recurrence care and denominators/analysis plans. The same people/legs are not new participants. Only material-request/research needs are recorded; no search/research was performed in this production."
    },
    {
      "item_id": "N10",
      "question_type": "Evidence condition",
      "question": "Are clinician confirmation and reporting/adjudication details separated?",
      "needed": "Original confirmation procedures and post-treatment measurement gaps",
      "role": "Required",
      "role_reason": "Needed to connect original confirmation procedures and post-treatment measurement gaps with the selected question, actual population/intervention/comparator, intervals/endpoints/estimands, denominators/repetition/exposure and reports/harms.",
      "application_exception": "Distinguish during/post-treatment intervals, first/repeated clinician-confirmed recurrence, people/time denominators/censoring, adherence/withdrawal/follow-up, HR/NNT/CI and post-treatment 27%, the separate PATCH II cohort, harms and applicability. Only original numbers are preserved; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or antibiotic/product-use/cellulitis-management/infection-prevention/treatment-replacement instructions.",
      "criterion": "Show original materials for original confirmation procedures and post-treatment measurement gaps together with selected-subclaim/parent boundaries, direct intervals/endpoints/estimands/denominators and the scope of external reading.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Event diagnosis/reporting, adjudication/masking, confirmation and post-treatment observation/missingness data. No formal RoB assessment in this production. Only material-request/research needs are recorded; no search/research was performed in this production."
    },
    {
      "item_id": "N11",
      "question_type": "Evidence condition",
      "question": "Are ITT and actual adherence/follow-up/withdrawal distinguished?",
      "needed": "Analysis as randomized and actual observed denominators",
      "role": "Required",
      "role_reason": "Needed to connect analysis as randomized and actual observed denominators with the selected question, actual population/intervention/comparator, intervals/endpoints/estimands, denominators/repetition/exposure and reports/harms.",
      "application_exception": "Distinguish during/post-treatment intervals, first/repeated clinician-confirmed recurrence, people/time denominators/censoring, adherence/withdrawal/follow-up, HR/NNT/CI and post-treatment 27%, the separate PATCH II cohort, harms and applicability. Only original numbers are preserved; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or antibiotic/product-use/cellulitis-management/infection-prevention/treatment-replacement instructions.",
      "criterion": "Show original materials for analysis as randomized and actual observed denominators together with selected-subclaim/parent boundaries, direct intervals/endpoints/estimands/denominators and the scope of external reading.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Original arm-specific flow, actual exposure/adherence, analysis/observation, censoring/withdrawal reasons and sensitivity plans. No new withdrawal counts/rates or adherence-effect calculations. Only material-request/research needs are recorded; no search/research was performed in this production."
    },
    {
      "item_id": "N12",
      "question_type": "Evidence condition",
      "question": "Are equal post-treatment proportions newly certified as equivalence/zero effect?",
      "needed": "Original 27%/lost protection and unverified CI",
      "role": "Required",
      "role_reason": "Needed to connect original 27%/lost protection and unverified CI with the selected question, actual population/intervention/comparator, intervals/endpoints/estimands, denominators/repetition/exposure and reports/harms.",
      "application_exception": "Distinguish during/post-treatment intervals, first/repeated clinician-confirmed recurrence, people/time denominators/censoring, adherence/withdrawal/follow-up, HR/NNT/CI and post-treatment 27%, the separate PATCH II cohort, harms and applicability. Only original numbers are preserved; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or antibiotic/product-use/cellulitis-management/infection-prevention/treatment-replacement instructions.",
      "criterion": "Show original materials for original 27%/lost protection and unverified CI together with selected-subclaim/parent boundaries, direct intervals/endpoints/estimands/denominators and the scope of external reading.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Post-treatment comparative effects/CI, interval/model, prespecified clinical thresholds, original denominators and data. Do not extend original grade D through new calculation/reassessment. Only material-request/research needs are recorded; no search/research was performed in this production."
    },
    {
      "item_id": "N13",
      "question_type": "Evidence condition",
      "question": "Does PATCH II concern the same trial/interval?",
      "needed": "Separate 123-person cohort with HR 0.53",
      "role": "Required",
      "role_reason": "Needed to connect separate 123-person cohort with HR 0.53 with the selected question, actual population/intervention/comparator, intervals/endpoints/estimands, denominators/repetition/exposure and reports/harms.",
      "application_exception": "Distinguish during/post-treatment intervals, first/repeated clinician-confirmed recurrence, people/time denominators/censoring, adherence/withdrawal/follow-up, HR/NNT/CI and post-treatment 27%, the separate PATCH II cohort, harms and applicability. Only original numbers are preserved; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or antibiotic/product-use/cellulitis-management/infection-prevention/treatment-replacement instructions.",
      "criterion": "Show original materials for separate 123-person cohort with HR 0.53 together with selected-subclaim/parent boundaries, direct intervals/endpoints/estimands/denominators and the scope of external reading.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Original PATCH II population/intervention/duration/intervals, events/denominators/plans and funding/author relationships. Do not copy PATCH I exposure, post-treatment 27%, funding/registration into it. Only material-request/research needs are recorded; no search/research was performed in this production."
    },
    {
      "item_id": "N14",
      "question_type": "Evidence condition",
      "question": "What is the hierarchy of during-treatment success and post-treatment analysis?",
      "needed": "First recurrence as primary and interval-specific plans",
      "role": "Required",
      "role_reason": "Needed to connect first recurrence as primary and interval-specific plans with the selected question, actual population/intervention/comparator, intervals/endpoints/estimands, denominators/repetition/exposure and reports/harms.",
      "application_exception": "Distinguish during/post-treatment intervals, first/repeated clinician-confirmed recurrence, people/time denominators/censoring, adherence/withdrawal/follow-up, HR/NNT/CI and post-treatment 27%, the separate PATCH II cohort, harms and applicability. Only original numbers are preserved; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or antibiotic/product-use/cellulitis-management/infection-prevention/treatment-replacement instructions.",
      "criterion": "Show original materials for first recurrence as primary and interval-specific plans together with selected-subclaim/parent boundaries, direct intervals/endpoints/estimands/denominators and the scope of external reading.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Interval-specific endpoints, censoring/analysis, hierarchy/multiplicity and amendments/publication timing in registration/protocol/SAP. Do not newly designate post-treatment analysis as confirmatory/exploratory. Only material-request/research needs are recorded; no search/research was performed in this production."
    },
    {
      "item_id": "N15",
      "question_type": "Evidence condition",
      "question": "Is permanent protection extended to a single course/other antibiotics?",
      "needed": "Applicability boundaries of study population/drug/duration",
      "role": "Required",
      "role_reason": "Needed to connect applicability boundaries of study population/drug/duration with the selected question, actual population/intervention/comparator, intervals/endpoints/estimands, denominators/repetition/exposure and reports/harms.",
      "application_exception": "Distinguish during/post-treatment intervals, first/repeated clinician-confirmed recurrence, people/time denominators/censoring, adherence/withdrawal/follow-up, HR/NNT/CI and post-treatment 27%, the separate PATCH II cohort, harms and applicability. Only original numbers are preserved; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or antibiotic/product-use/cellulitis-management/infection-prevention/treatment-replacement instructions.",
      "criterion": "Show original materials for applicability boundaries of study population/drug/duration together with selected-subclaim/parent boundaries, direct intervals/endpoints/estimands/denominators and the scope of external reading.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Direct population/drug/route/duration, during/post-treatment effects/CI and harms for each applicability question. No new antibiotic selection, extension/discontinuation or cellulitis-management guidance. Only material-request/research needs are recorded; no search/research was performed in this production."
    },
    {
      "item_id": "N16",
      "question_type": "Harm-information gaps supplementing the efficacy table",
      "question": "Are adverse-event reporter counts and event counts distinguished?",
      "needed": "37 versus 48 people, P=.50",
      "role": "Supplementary",
      "role_reason": "Needed to connect 37 versus 48 people, P=.50 with the selected question, actual population/intervention/comparator, intervals/endpoints/estimands, denominators/repetition/exposure and reports/harms.",
      "application_exception": "Distinguish during/post-treatment intervals, first/repeated clinician-confirmed recurrence, people/time denominators/censoring, adherence/withdrawal/follow-up, HR/NNT/CI and post-treatment 27%, the separate PATCH II cohort, harms and applicability. Only original numbers are preserved; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or antibiotic/product-use/cellulitis-management/infection-prevention/treatment-replacement instructions.",
      "criterion": "Show original materials for 37 versus 48 people, P=.50 together with selected-subclaim/parent boundaries, direct intervals/endpoints/estimands/denominators and the scope of external reading.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Original AE collection, reporter/event aggregation, arm exposure/harm denominators, intervals/discontinuation/relatedness and types. No new harm rates/effects or management instructions. Only material-request/research needs are recorded; no search/research was performed in this production."
    },
    {
      "item_id": "N17",
      "question_type": "Harm-information gaps supplementing the efficacy table",
      "question": "Are allergy, gastrointestinal and resistance harm boundaries retained?",
      "needed": "Long-term antibiotic burdens and interval-specific data",
      "role": "Supplementary",
      "role_reason": "Needed to connect long-term antibiotic burdens and interval-specific data with the selected question, actual population/intervention/comparator, intervals/endpoints/estimands, denominators/repetition/exposure and reports/harms.",
      "application_exception": "Distinguish during/post-treatment intervals, first/repeated clinician-confirmed recurrence, people/time denominators/censoring, adherence/withdrawal/follow-up, HR/NNT/CI and post-treatment 27%, the separate PATCH II cohort, harms and applicability. Only original numbers are preserved; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or antibiotic/product-use/cellulitis-management/infection-prevention/treatment-replacement instructions.",
      "criterion": "Show original materials for long-term antibiotic burdens and interval-specific data together with selected-subclaim/parent boundaries, direct intervals/endpoints/estimands/denominators and the scope of external reading.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Harm-specific collection/exposure/denominators, discontinuation/relatedness, resistance measurement and long-term/post-treatment data. No antibiotic/infection-prevention/treatment instructions. Only material-request/research needs are recorded; no search/research was performed in this production."
    },
    {
      "item_id": "N18",
      "question_type": "Evidence condition",
      "question": "Are during-treatment signals transferred to post-treatment mechanism/protection?",
      "needed": "Effect timing and direct persistence data",
      "role": "Required",
      "role_reason": "Needed to connect effect timing and direct persistence data with the selected question, actual population/intervention/comparator, intervals/endpoints/estimands, denominators/repetition/exposure and reports/harms.",
      "application_exception": "Distinguish during/post-treatment intervals, first/repeated clinician-confirmed recurrence, people/time denominators/censoring, adherence/withdrawal/follow-up, HR/NNT/CI and post-treatment 27%, the separate PATCH II cohort, harms and applicability. Only original numbers are preserved; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or antibiotic/product-use/cellulitis-management/infection-prevention/treatment-replacement instructions.",
      "criterion": "Show original materials for effect timing and direct persistence data together with selected-subclaim/parent boundaries, direct intervals/endpoints/estimands/denominators and the scope of external reading.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Direct post-treatment plans, observation/risk populations, re-exposure/concurrent treatment and effects/CI/harms. No invented persistent protection/management instructions. Only material-request/research needs are recorded; no search/research was performed in this production."
    },
    {
      "item_id": "N19",
      "question_type": "Evidence condition",
      "question": "What materials were actually read or acquired?",
      "needed": "Preserved summary and external original materials",
      "role": "Required",
      "role_reason": "Needed to connect preserved summary and external original materials with the selected question, actual population/intervention/comparator, endpoints/estimands, denominators/tests/follow-up and reports/harms.",
      "application_exception": "Distinguish during/post-treatment intervals, first/repeated clinician-confirmed recurrence, people/time denominators/censoring, adherence/withdrawal/follow-up, HR/NNT/CI and post-treatment 27%, the separate PATCH II cohort, harms and applicability. Only original numbers are preserved; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or antibiotic/product-use/cellulitis-management/infection-prevention/treatment-replacement instructions.",
      "criterion": "Show original materials for preserved summary and external original materials together with selected-subclaim/parent boundaries, direct endpoints/estimands/denominators and the scope of external reading.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Records of actual acquisition/reading scope, versions and dates. No external-link/click/access testing. Only material requests/research needs are recorded; no search or research was performed in that production."
    },
    {
      "item_id": "N20",
      "question_type": "Evidence condition",
      "question": "Are historical registration/plans distinguished from current reading?",
      "needed": "Original registration identifier and detailed comparison",
      "role": "Required",
      "role_reason": "Needed to connect original registration identifier and detailed comparison with the selected question, actual population/intervention/comparator, endpoints/estimands, denominators/tests/follow-up and reports/harms.",
      "application_exception": "Distinguish during/post-treatment intervals, first/repeated clinician-confirmed recurrence, people/time denominators/censoring, adherence/withdrawal/follow-up, HR/NNT/CI and post-treatment 27%, the separate PATCH II cohort, harms and applicability. Only original numbers are preserved; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or antibiotic/product-use/cellulitis-management/infection-prevention/treatment-replacement instructions.",
      "criterion": "Show original materials for original registration identifier and detailed comparison together with selected-subclaim/parent boundaries, direct endpoints/estimands/denominators and the scope of external reading.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Actual registration versions/publication, recruitment/start/amendments, endpoints/models/analysis intervals and original report links. Preserve historical descriptions without new certification of plans or prospective specification. Only the material request/research need is recorded; no lookup or research is performed now."
    },
    {
      "item_id": "N21",
      "question_type": "Evidence condition",
      "question": "Have protocol/SAP and analysis/missing-data plans been acquired?",
      "needed": "Separate materials for prespecified plans/changes",
      "role": "Required",
      "role_reason": "Needed to connect separate prespecified-plan and amendment materials with the selected question, actual population/intervention/comparator, endpoints/estimands, denominators/tests/follow-up and reports/harms.",
      "application_exception": "Distinguish during/post-treatment intervals, first/repeated clinician-confirmed recurrence, people/time denominators/censoring, adherence/withdrawal/follow-up, HR/NNT/CI and post-treatment 27%, the separate PATCH II cohort, harms and applicability. Only original numbers are preserved; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or antibiotic/product-use/cellulitis-management/infection-prevention/treatment-replacement instructions.",
      "criterion": "Show original materials for separate prespecified-plan and amendment materials together with selected-subclaim/parent boundaries, direct endpoints/estimands/denominators and the scope of external reading.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Protocol, SAP, amendments, estimands/denominators/analyses, all endpoints and publication timing. Unread materials are not assumed absent. Only the material request/research need is recorded; no lookup or research is performed now."
    },
    {
      "item_id": "N22",
      "question_type": "Evidence condition",
      "question": "Are sponsorship, funding, products, authors and research involvement separated?",
      "needed": "Four company-involvement items and nonprofit/public/academic support",
      "role": "Required",
      "role_reason": "Needed to connect four company-involvement items and nonprofit/public/academic support with the selected question, actual population/intervention/comparator, endpoints/estimands, denominators/tests/follow-up and reports/harms.",
      "application_exception": "Distinguish during/post-treatment intervals, first/repeated clinician-confirmed recurrence, people/time denominators/censoring, adherence/withdrawal/follow-up, HR/NNT/CI and post-treatment 27%, the separate PATCH II cohort, harms and applicability. Only original numbers are preserved; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or antibiotic/product-use/cellulitis-management/infection-prevention/treatment-replacement instructions.",
      "criterion": "Show original materials for four company-involvement items and nonprofit/public/academic support together with selected-subclaim/parent boundaries, direct endpoints/estimands/denominators and the scope of external reading.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Separate original materials on company cash funding, product support, employee authors/outside relationships, design/analysis/data control and nonprofit/institutional support. Original independence-axis values are not new certification of all items or independence. Only the material request/research need is recorded; no lookup or research is performed now."
    },
    {
      "item_id": "N23",
      "question_type": "Evidence condition",
      "question": "Are results by interval/endpoint distinguished from information gaps?",
      "needed": "Direct results, unverified details and access status",
      "role": "Required",
      "role_reason": "Needed to connect direct results, unverified details and access status with the selected question, actual population/intervention/comparator, endpoints/estimands, denominators/tests/follow-up and reports/harms.",
      "application_exception": "Distinguish during/post-treatment intervals, first/repeated clinician-confirmed recurrence, people/time denominators/censoring, adherence/withdrawal/follow-up, HR/NNT/CI and post-treatment 27%, the separate PATCH II cohort, harms and applicability. Only original numbers are preserved; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or antibiotic/product-use/cellulitis-management/infection-prevention/treatment-replacement instructions.",
      "criterion": "Show original materials for direct results, unverified details and access status together with selected-subclaim/parent boundaries, direct endpoints/estimands/denominators and the scope of external reading.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Direct measurements, original interval/endpoint tables, plans, observations/denominators and actual access records. Do not substitute unread with unreported or null with exactly zero effect/equivalence. Only the material request/research need is recorded; no lookup or research is performed now."
    },
    {
      "item_id": "N24",
      "question_type": "Evidence condition",
      "question": "Are reports, trials, people, intervals, events and related sheets separated?",
      "needed": "Linked records versus unique trials/participants",
      "role": "Required",
      "role_reason": "Needed to connect linked records and unique trials/participants with the selected question, actual population/intervention/comparator, endpoints/estimands, denominators/tests/follow-up and reports/harms.",
      "application_exception": "Distinguish during/post-treatment intervals, first/repeated clinician-confirmed recurrence, people/time denominators/censoring, adherence/withdrawal/follow-up, HR/NNT/CI and post-treatment 27%, the separate PATCH II cohort, harms and applicability. Only original numbers are preserved; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or antibiotic/product-use/cellulitis-management/infection-prevention/treatment-replacement instructions.",
      "criterion": "Show original materials for linked records and unique trials/participants together with selected-subclaim/parent boundaries, direct endpoints/estimands/denominators and the scope of external reading.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Original reports/registration, cohorts/intervals, events/repetition/observation and overlap relationships. Unique-trial/participant totals remain unrecorded. Only the material request/research need is recorded; no lookup or research is performed now."
    },
    {
      "item_id": "N25",
      "question_type": "Evidence condition",
      "question": "Are the original single trial and separate independent replication distinguished?",
      "needed": "Parent R1, independence axis and direct replication",
      "role": "Supplementary",
      "role_reason": "Needed to connect parent R1, independence axis and direct replication with the selected question, actual population/intervention/comparator, endpoints/estimands, denominators/tests/follow-up and reports/harms.",
      "application_exception": "Distinguish during/post-treatment intervals, first/repeated clinician-confirmed recurrence, people/time denominators/censoring, adherence/withdrawal/follow-up, HR/NNT/CI and post-treatment 27%, the separate PATCH II cohort, harms and applicability. Only original numbers are preserved; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or antibiotic/product-use/cellulitis-management/infection-prevention/treatment-replacement instructions.",
      "criterion": "Show original materials for parent R1, independence axis and direct replication together with selected-subclaim/parent boundaries, direct endpoints/estimands/denominators and the scope of external reading.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Separate prespecified confirmation matching the question, with direct population/intervention/comparator/endpoint/duration, denominators/effects/CI and funding/author relationships. No new search or independence verdict. Only the material request/research need is recorded; no lookup or research is performed now."
    },
    {
      "item_id": "N26",
      "question_type": "Evidence condition",
      "question": "Are the subclaim grade and parent score/axes preserved?",
      "needed": "Selected D, missing score/status/axes and parent context",
      "role": "Required",
      "role_reason": "Needed to connect selected D, missing score/status/axes and parent context with the selected question, actual population/intervention/comparator, endpoints/estimands, denominators/tests/follow-up and reports/harms.",
      "application_exception": "Distinguish during/post-treatment intervals, first/repeated clinician-confirmed recurrence, people/time denominators/censoring, adherence/withdrawal/follow-up, HR/NNT/CI and post-treatment 27%, the separate PATCH II cohort, harms and applicability. Only original numbers are preserved; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or antibiotic/product-use/cellulitis-management/infection-prevention/treatment-replacement instructions.",
      "criterion": "Show original materials for selected D, missing score/status/axes and parent context together with selected-subclaim/parent boundaries, direct endpoints/estimands/denominators and the scope of external reading.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Existing subclaim/parent-boundary review and actual correction materials. Distinguish absent/original axis values and their history. Only the material request/research need is recorded; no lookup or research is performed now."
    },
    {
      "item_id": "N27",
      "question_type": "Evidence condition",
      "question": "Are both languages, citations and absent fields preserved?",
      "needed": "Both original languages and absent separate classification information",
      "role": "Required",
      "role_reason": "Needed to connect both original languages and absent classification fields with the selected question, actual population/intervention/comparator, endpoints/estimands, denominators/tests/follow-up and reports/harms.",
      "application_exception": "Distinguish during/post-treatment intervals, first/repeated clinician-confirmed recurrence, people/time denominators/censoring, adherence/withdrawal/follow-up, HR/NNT/CI and post-treatment 27%, the separate PATCH II cohort, harms and applicability. Only original numbers are preserved; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or antibiotic/product-use/cellulitis-management/infection-prevention/treatment-replacement instructions.",
      "criterion": "Show original materials for both original languages and absent classification fields together with selected-subclaim/parent boundaries, direct endpoints/estimands/denominators and the scope of external reading.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Materials for reviewing bilingual terminology, time/event/effect units, selected scope and absent fields. Production explanations are distinguished from original records. Only the material request/research need is recorded; no lookup or research is performed now."
    },
    {
      "item_id": "N28",
      "question_type": "Evidence condition",
      "question": "Are source dates/corrections/history separated from production dates?",
      "needed": "Original 2026-08-26 and new conditions/application",
      "role": "Required",
      "role_reason": "Needed to connect original 2026-08-26 and new conditions/application with the selected question, actual population/intervention/comparator, endpoints/estimands, denominators/tests/follow-up and reports/harms.",
      "application_exception": "Distinguish during/post-treatment intervals, first/repeated clinician-confirmed recurrence, people/time denominators/censoring, adherence/withdrawal/follow-up, HR/NNT/CI and post-treatment 27%, the separate PATCH II cohort, harms and applicability. Only original numbers are preserved; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or antibiotic/product-use/cellulitis-management/infection-prevention/treatment-replacement instructions.",
      "criterion": "Show original materials for original 2026-08-26 and new conditions/application together with selected-subclaim/parent boundaries, direct endpoints/estimands/denominators and the scope of external reading.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Update materials separating originals, events, conditions/observations and verdict decisions when new evidence/corrections arise. Historical wording is not completed clinical content review here. Only material requests/research needs are recorded; no search or research was performed in that production."
    },
    {
      "item_id": "N29",
      "question_type": "Evidence condition",
      "question": "What direct materials would fill the selected gaps?",
      "needed": "Direct interval/endpoint effects, denominators/CI and follow-up",
      "role": "Supplementary",
      "role_reason": "Needed to connect direct interval/endpoint effects, denominators/CI and follow-up with the selected question, actual population/intervention/comparator, endpoints/estimands, denominators/tests/follow-up and reports/harms.",
      "application_exception": "Distinguish during/post-treatment intervals, first/repeated clinician-confirmed recurrence, people/time denominators/censoring, adherence/withdrawal/follow-up, HR/NNT/CI and post-treatment 27%, the separate PATCH II cohort, harms and applicability. Only original numbers are preserved; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or antibiotic/product-use/cellulitis-management/infection-prevention/treatment-replacement instructions.",
      "criterion": "Show original materials for direct interval/endpoint effects, denominators/CI and follow-up together with selected-subclaim/parent boundaries, direct endpoints/estimands/denominators and the scope of external reading.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Original tables/plans, interval/endpoint definitions, estimands/CI, observation/censoring/denominators, exposure/adherence, independent confirmation and long-term harms. Only the need is recorded; no new lookup/research. Only the material request/research need is recorded; no lookup or research is performed now."
    },
    {
      "item_id": "N30",
      "question_type": "Evidence condition",
      "question": "Are applicability records separated from content review and instructions?",
      "needed": "Applicability records, existing candidate history and content review",
      "role": "Supplementary",
      "role_reason": "Needed to connect condition records, historical candidates and content review with the selected question, actual population/intervention/comparator, endpoints/estimands, denominators/tests/follow-up and reports/harms.",
      "application_exception": "Distinguish during/post-treatment intervals, first/repeated clinician-confirmed recurrence, people/time denominators/censoring, adherence/withdrawal/follow-up, HR/NNT/CI and post-treatment 27%, the separate PATCH II cohort, harms and applicability. Only original numbers are preserved; no new calculations, invented quantities, effects/CI, grades/reassessment, independence certification or antibiotic/product-use/cellulitis-management/infection-prevention/treatment-replacement instructions.",
      "criterion": "Show original materials for condition records, historical candidates and content review together with selected-subclaim/parent boundaries, direct endpoints/estimands/denominators and the scope of external reading.",
      "basis": "Existing C/E/H distinctions of questions, populations, interventions, comparisons, reports/trials, endpoints/denominators and harms referenced for production",
      "condition_origin": "Applicability conditions for preserved existing subclaims; not prespecified registration, official-tool execution or completed review",
      "proposed_research": "Materials needed: Content review and subsequent actual evidence/correction work. Original content-production scope excludes clinical QA/testing, external-link/access/web/API research, new calculations/grades and antibiotic/product-use/cellulitis-management/infection-prevention/treatment-replacement instructions. Only material-request/research needs are recorded; no search/research was performed in this production."
    }
  ]
}