# Olistic Women finished product · Six-month TrichoScan hair density — Evidence Check

Verdict 2956 · Evidence Check

Stored-material review date: Not recorded  
Original evidence cut-off: 2026-08-26  
Review-criteria version: 1.0  
Public page/material preparation date: 2026-10-12

Clinical papers were not read directly; existing review summaries were checked. No new clinical-literature search was performed. Unverified does not mean that research is absent or that there is no effect.

## Assessment scope

- Population: 106 premenopausal women diagnosed with telogen effluvium allocated (53/53); analyzed, measured and completed denominators by timepoint are unverified
- Ingredient, formulation and route: Olistic Women finished drinkable multi-ingredient nutraceutical
- Dose: Original study exposure: one 25-mL vial/day for six months; not intake guidance or product recommendations
- Comparator: Trial placebo; detailed composition and blinding specifications unread
- Measured outcome: Change from baseline to day 180 in TrichoScan hair density, hairs/cm²; distinct from appearance, perception and hair-cycle ratios
- Duration: Six months/180 days; the day-90 repeat timepoint is a separate result, and persistence after completion is unverified
- Questions outside this scope: No new research, effects, CIs, calculations, assessments, independent certification, participant totals or product/drug-use/dosing/treatment or adjunct-treatment reduction/discontinuation guidance is created

## Checklist items

### N01 · What are the selected finished-product question and original subclaim assessment?

Verification status: Partly verified  
Reading scope: Summary read; related external material unread

- Current findings: The selected row concerns increased six-month TrichoScan hair density with this finished product, original grade C and a note of day-180 +27.31 versus +18.23 hairs/cm². The parent is C with 50 points.
- Why unverified: Display preserved-summary information, scope and direct gaps in production; this is not completed content review or a new clinical assessment
- Reason for missing information: The selected row has no score, status or axes. Do not fill subclaim scores/axes from parent values or create a new assessment.
- Required materials and conditions: Original six-month TrichoScan hair-density text, grade and note
- Materials to obtain first: Selected row and original parent assessment
- Further research: Distinguish the original assessment from production and review of existing content
- Conditions for verification: Original six-month TrichoScan hair-density text, grade and note; preserve original values, direct observations, scope and gaps without creating new effects, assessments, calculations or independent certification
- Why this condition is needed: Production condition exposing direct original material, formulation, comparison, denominators and gaps for the selected endpoint
- Application exceptions: Do not fill unverified selected material with other endpoints, formulations, trials or person/eye/measurement units
- Remaining uncertainty: External abstract, full text, registration, protocol and SAP unread; no new calculation, content review or clinical checks
- Referenced methods: Retain the production copy of existing methodology application records and methodology linkage; full definition review and official certification are incomplete
- Related sources: R01

### N02 · What are the actual population and scope of telogen-effluvium diagnosis?

Verification status: Partly verified  
Reading scope: Summary read; related external material unread

- Current findings: CT-OW-02 allocated 106 premenopausal women diagnosed with telogen effluvium, 53 per group.
- Why unverified: Display preserved-summary information, scope and direct gaps in production; this is not completed content review or a new clinical assessment
- Reason for missing information: Diagnostic details, age, baseline hair, causes and applicability to other hair loss, men or postmenopausal women are unverified.
- Required materials and conditions: Premenopausal women, diagnosis, eligibility, baseline and exclusions
- Materials to obtain first: Eligibility, diagnosis and baseline-characteristic tables
- Further research: Distinguish the recruited population from other hair-loss conditions and populations
- Conditions for verification: Premenopausal women, diagnosis, eligibility, baseline and exclusions; preserve original values, direct observations, scope and gaps without creating new effects, assessments, calculations or independent certification
- Why this condition is needed: Production condition exposing direct original material, formulation, comparison, denominators and gaps for the selected endpoint
- Application exceptions: Do not fill unverified selected material with other endpoints, formulations, trials or person/eye/measurement units
- Remaining uncertainty: External abstract, full text, registration, protocol and SAP unread; no new calculation, content review or clinical checks
- Referenced methods: Retain the production copy of existing methodology application records and methodology linkage; full definition review and official certification are incomplete
- Related sources: R01

### N03 · What are the actual finished product and study exposure?

Verification status: Partly verified  
Reading scope: Summary read; related external material unread

- Current findings: Exposure to one 25-mL vial/day of the Olistic Women drinkable multi-ingredient nutraceutical for six months is recorded.
- Why unverified: Display preserved-summary information, scope and direct gaps in production; this is not completed content review or a new clinical assessment
- Reason for missing information: This preserves study identity, not intake guidance or product recommendations. Full ingredients, batches and adherence details are absent from the summary.
- Required materials and conditions: Olistic Women finished product, formulation, study exposure and duration
- Materials to obtain first: Finished-product, ingredient, batch and study-exposure specifications
- Further research: Distinguish finished-product identity from actual exposure and guidance
- Conditions for verification: Olistic Women finished product, formulation, study exposure and duration; preserve original values, direct observations, scope and gaps without creating new effects, assessments, calculations or independent certification
- Why this condition is needed: Production condition exposing direct original material, formulation, comparison, denominators and gaps for the selected endpoint
- Application exceptions: Do not fill unverified selected material with other endpoints, formulations, trials or person/eye/measurement units
- Remaining uncertainty: External abstract, full text, registration, protocol and SAP unread; no new calculation, content review or clinical checks
- Referenced methods: Retain the production copy of existing methodology application records and methodology linkage; full definition review and official certification are incomplete
- Related sources: R01

### N04 · Are placebo composition, appearance and blinding verified?

Verification status: Partly verified  
Reading scope: Summary read; related external material unread

- Current findings: The trial was multicenter, double-blind and placebo-controlled; the company supplied product and placebo.
- Why unverified: Display preserved-summary information, scope and direct gaps in production; this is not completed content review or a new clinical assessment
- Reason for missing information: Placebo ingredients, appearance/sensory properties and blinding success/unblinding details are unread. Do not newly certify complete matching.
- Required materials and conditions: Product/placebo composition, matching and blinding implementation
- Materials to obtain first: Active/placebo specifications and blinding methods
- Further research: Distinguish the design name from actual blinding implementation
- Conditions for verification: Product/placebo composition, matching and blinding implementation; preserve original values, direct observations, scope and gaps without creating new effects, assessments, calculations or independent certification
- Why this condition is needed: Production condition exposing direct original material, formulation, comparison, denominators and gaps for the selected endpoint
- Application exceptions: Do not fill unverified selected material with other endpoints, formulations, trials or person/eye/measurement units
- Remaining uncertainty: External abstract, full text, registration, protocol and SAP unread; no new calculation, content review or clinical checks
- Referenced methods: Retain the production copy of existing methodology application records and methodology linkage; full definition review and official certification are incomplete
- Related sources: R01

### N05 · Are allocation, analysis, completion and missing-data denominators separated?

Verification status: Partly verified  
Reading scope: Summary read; related external material unread

- Current findings: The original evidence lists 106 randomized (53/53).
- Why unverified: Display preserved-summary information, scope and direct gaps in production; this is not completed content review or a new clinical assessment
- Reason for missing information: Measured, analyzed, completed and dropout denominators at days 90/180 are absent from the summary. Do not turn 106 allocated into an analysis denominator with all participants completing.
- Required materials and conditions: 106 allocated, 53/53, measurements/analysis/exclusions by timepoint
- Materials to obtain first: Group flow, analysis and measurement tables by timepoint
- Further research: Separate allocation from actually observed and analyzed denominators
- Conditions for verification: 106 allocated, 53/53, measurements/analysis/exclusions by timepoint; preserve original values, direct observations, scope and gaps without creating new effects, assessments, calculations or independent certification
- Why this condition is needed: Production condition exposing direct original material, formulation, comparison, denominators and gaps for the selected endpoint
- Application exceptions: Do not fill unverified selected material with other endpoints, formulations, trials or person/eye/measurement units
- Remaining uncertainty: External abstract, full text, registration, protocol and SAP unread; no new calculation, content review or clinical checks
- Referenced methods: Retain the production copy of existing methodology application records and methodology linkage; full definition review and official certification are incomplete
- Related sources: R01

### N06 · What is the original record scope for random-sequence generation and allocation concealment?

Verification status: Partly verified  
Reading scope: Summary read; related external material unread

- Current findings: The preserved research explanation says random-sequence generation and allocation-concealment methods were not confirmed in the public paper.
- Why unverified: Display preserved-summary information, scope and direct gaps in production; this is not completed content review or a new clinical assessment
- Reason for missing information: This does not mean the external paper was read now. Do not use parent B1 or the design name as new methods review or allocation certification.
- Required materials and conditions: Sequence, concealment, baseline, actual implementation and original descriptions
- Materials to obtain first: Original allocation/concealment, baseline and methods material
- Further research: Distinguish historically unverified methods from current summary reading
- Conditions for verification: Sequence, concealment, baseline, actual implementation and original descriptions; preserve original values, direct observations, scope and gaps without creating new effects, assessments, calculations or independent certification
- Why this condition is needed: Production condition exposing direct original material, formulation, comparison, denominators and gaps for the selected endpoint
- Application exceptions: Do not fill unverified selected material with other endpoints, formulations, trials or person/eye/measurement units
- Remaining uncertainty: External abstract, full text, registration, protocol and SAP unread; no new calculation, content review or clinical checks
- Referenced methods: Retain the production copy of existing methodology application records and methodology linkage; full definition review and official certification are incomplete
- Related sources: R01

### N07 · Are missing-data handling, analysis populations and effects of interest known?

Verification status: Partly verified  
Reading scope: Summary read; related external material unread

- Current findings: The original summary says detailed missing-data handling was not confirmed in the public paper.
- Why unverified: Display preserved-summary information, scope and direct gaps in production; this is not completed content review or a new clinical assessment
- Reason for missing information: Do not arbitrarily label analysis populations, adjustment, imputation or completer effects. Do not fill gaps with allocation denominators.
- Required materials and conditions: Group exclusions, missingness, ITT/PP, models and adjustment
- Materials to obtain first: Analysis-population, missing-data, model and sensitivity material
- Further research: Separate allocation, actual use, completers and missing-data assumptions
- Conditions for verification: Group exclusions, missingness, ITT/PP, models and adjustment; preserve original values, direct observations, scope and gaps without creating new effects, assessments, calculations or independent certification
- Why this condition is needed: Production condition exposing direct original material, formulation, comparison, denominators and gaps for the selected endpoint
- Application exceptions: Do not fill unverified selected material with other endpoints, formulations, trials or person/eye/measurement units
- Remaining uncertainty: External abstract, full text, registration, protocol and SAP unread; no new calculation, content review or clinical checks
- Referenced methods: Retain the production copy of existing methodology application records and methodology linkage; full definition review and official certification are incomplete
- Related sources: R01

### N08 · Can concurrent treatment, changes in hair-loss causes and product adherence be distinguished?

Verification status: Unverified  
Reading scope: Summary read; related external material unread

- Current findings: The current preserved summary gives a finished-product/placebo comparison and six months.
- Why unverified: Display preserved-summary information, scope and direct gaps in production; this is not completed content review or a new clinical assessment
- Reason for missing information: Concurrent exposure, changes in disease causes, adherence and between-group deviations are unspecified. Do not claim product contribution was separated from other changes or provide treatment-change methods.
- Required materials and conditions: Concurrent treatment, nutrition, other products, causes, changes and adherence
- Materials to obtain first: Group tables of concomitant exposure, adherence, changes and baseline causes
- Further research: Distinguish finished-product effects from other possible changes
- Conditions for verification: Concurrent treatment, nutrition, other products, causes, changes and adherence; preserve original values, direct observations, scope and gaps without creating new effects, assessments, calculations or independent certification
- Why this condition is needed: Production condition exposing direct original material, formulation, comparison, denominators and gaps for the selected endpoint
- Application exceptions: Do not fill unverified selected material with other endpoints, formulations, trials or person/eye/measurement units
- Remaining uncertainty: External abstract, full text, registration, protocol and SAP unread; no new calculation, content review or clinical checks
- Referenced methods: Retain the production copy of existing methodology application records and methodology linkage; full definition review and official certification are incomplete
- Related sources: R01

### N09 · What are the primary endpoint’s measurement, unit and definition?

Verification status: Partly verified  
Reading scope: Summary read; related external material unread

- Current findings: The primary endpoint was change from baseline in hair density measured by TrichoScan phototrichoscopy.
- Why unverified: Display preserved-summary information, scope and direct gaps in production; this is not completed content review or a new clinical assessment
- Reason for missing information: It differs from appearance, satisfaction and patient perception. Imaging site/area, device, assessors, standardization and repeated-measurement handling details are unread.
- Required materials and conditions: TrichoScan phototrichoscopy, change from baseline in density and hairs/cm²
- Materials to obtain first: Imaging, measurement, unit and assessment manuals and original tables
- Further research: Distinguish device-measured density from patient-centered outcomes
- Conditions for verification: TrichoScan phototrichoscopy, change from baseline in density and hairs/cm²; preserve original values, direct observations, scope and gaps without creating new effects, assessments, calculations or independent certification
- Why this condition is needed: Production condition exposing direct original material, formulation, comparison, denominators and gaps for the selected endpoint
- Application exceptions: Do not fill unverified selected material with other endpoints, formulations, trials or person/eye/measurement units
- Remaining uncertainty: External abstract, full text, registration, protocol and SAP unread; no new calculation, content review or clinical checks
- Referenced methods: Retain the production copy of existing methodology application records and methodology linkage; full definition review and official certification are incomplete
- Related sources: R01

### N10 · Do day-180 changes by group differ from final density?

Verification status: Partly verified  
Reading scope: Summary read; related external material unread

- Current findings: Day-180 change is recorded as product +27.31±2.61 versus placebo +18.23±2.98 hairs/cm².
- Why unverified: Display preserved-summary information, scope and direct gaps in production; this is not completed content review or a new clinical assessment
- Reason for missing information: Do not turn changes into final density. The summary does not identify ± as SD or SE; do not calculate baseline/final values or new between-group differences.
- Required materials and conditions: Baseline, change and final values for each group and definition of ±
- Materials to obtain first: Original group baseline/change/final-value tables and ± definitions
- Further research: Distinguish changes, absolute values, dispersion and precision
- Conditions for verification: Baseline, change and final values for each group and definition of ±; preserve original values, direct observations, scope and gaps without creating new effects, assessments, calculations or independent certification
- Why this condition is needed: Production condition exposing direct original material, formulation, comparison, denominators and gaps for the selected endpoint
- Application exceptions: Do not fill unverified selected material with other endpoints, formulations, trials or person/eye/measurement units
- Remaining uncertainty: External abstract, full text, registration, protocol and SAP unread; no new calculation, content review or clinical checks
- Referenced methods: Retain the production copy of existing methodology application records and methodology linkage; full definition review and official certification are incomplete
- Related sources: R01

### N11 · What are the test and confidence interval for the selected between-group comparison?

Verification status: Partly verified  
Reading scope: Summary read; related external material unread

- Current findings: The preserved summary gives P<0.01 for the day-180 hair-density comparison and says the 95% CI was not reported.
- Why unverified: Display preserved-summary information, scope and direct gaps in production; this is not completed content review or a new clinical assessment
- Reason for missing information: Do not create new differences, CIs, relative density or hypothetical examples. Unreported effect intervals must not become confirmed precision.
- Required materials and conditions: Day-180 comparison, effect scale, P value and CI
- Materials to obtain first: Original between-group effect, test and interval tables
- Further research: Display directly reported tests together with gaps in effects/CIs
- Conditions for verification: Day-180 comparison, effect scale, P value and CI; preserve original values, direct observations, scope and gaps without creating new effects, assessments, calculations or independent certification
- Why this condition is needed: Production condition exposing direct original material, formulation, comparison, denominators and gaps for the selected endpoint
- Application exceptions: Do not fill unverified selected material with other endpoints, formulations, trials or person/eye/measurement units
- Remaining uncertainty: External abstract, full text, registration, protocol and SAP unread; no new calculation, content review or clinical checks
- Referenced methods: Retain the production copy of existing methodology application records and methodology linkage; full definition review and official certification are incomplete
- Related sources: R01

### N12 · Does an important clinical difference explain the device measurement?

Verification status: Partly verified  
Reading scope: Summary read; related external material unread

- Current findings: The preserved counterview says a clinically important minimum hairs/cm² threshold was not reported.
- Why unverified: Display preserved-summary information, scope and direct gaps in production; this is not completed content review or a new clinical assessment
- Reason for missing information: Do not invent an important difference, normalized hair fullness or a visible-change criterion.
- Required materials and conditions: Prespecified hairs/cm² importance, direct perception and clinical criteria
- Materials to obtain first: Prespecified importance criteria and direct appearance/perception results
- Further research: Separate statistical values from clinical importance
- Conditions for verification: Prespecified hairs/cm² importance, direct perception and clinical criteria; preserve original values, direct observations, scope and gaps without creating new effects, assessments, calculations or independent certification
- Why this condition is needed: Production condition exposing direct original material, formulation, comparison, denominators and gaps for the selected endpoint
- Application exceptions: Do not fill unverified selected material with other endpoints, formulations, trials or person/eye/measurement units
- Remaining uncertainty: External abstract, full text, registration, protocol and SAP unread; no new calculation, content review or clinical checks
- Referenced methods: Retain the production copy of existing methodology application records and methodology linkage; full definition review and official certification are incomplete
- Related sources: R01

### N13 · Was the day-90 result counted as independent replication or merged with day 180?

Verification status: Partly verified  
Reading scope: Summary read; related external material unread

- Current findings: The original description says between-group differences occurred at both days 90 and 180.
- Why unverified: Display preserved-summary information, scope and direct gaps in production; this is not completed content review or a new clinical assessment
- Reason for missing information: Exact day-90 values, P values, CIs and denominators are absent from the summary. Do not count repeat timepoints as new trials/participants or copy day-180 values.
- Required materials and conditions: Values, denominators, plans and measurements by timepoint
- Materials to obtain first: Day-90/day-180 result and denominator tables
- Further research: Distinguish direct timepoint data from shared participants and measurements
- Conditions for verification: Values, denominators, plans and measurements by timepoint; preserve original values, direct observations, scope and gaps without creating new effects, assessments, calculations or independent certification
- Why this condition is needed: Production condition exposing direct original material, formulation, comparison, denominators and gaps for the selected endpoint
- Application exceptions: Do not fill unverified selected material with other endpoints, formulations, trials or person/eye/measurement units
- Remaining uncertainty: External abstract, full text, registration, protocol and SAP unread; no new calculation, content review or clinical checks
- Referenced methods: Retain the production copy of existing methodology application records and methodology linkage; full definition review and official certification are incomplete
- Related sources: R01

### N14 · Was the secondary hair-cycle ratio merged with density?

Verification status: Partly verified  
Reading scope: Summary read; related external material unread

- Current findings: The original text gives a prespecified secondary ratio of product 8.20:1→14.19:1 versus placebo 7.43:1→8.76:1, P<0.001.
- Why unverified: Display preserved-summary information, scope and direct gaps in production; this is not completed content review or a new clinical assessment
- Reason for missing information: This differs from hair density in hairs/cm². Do not convert the ratio to density, individual hair counts or between-group differences or calculate new values.
- Required materials and conditions: Anagen-to-catagen/telogen ratio, hierarchy and definition
- Materials to obtain first: Secondary-ratio definitions, plans and original tables
- Further research: Distinguish density, hair-cycle ratios and analysis hierarchy
- Conditions for verification: Anagen-to-catagen/telogen ratio, hierarchy and definition; preserve original values, direct observations, scope and gaps without creating new effects, assessments, calculations or independent certification
- Why this condition is needed: Production condition exposing direct original material, formulation, comparison, denominators and gaps for the selected endpoint
- Application exceptions: Do not fill unverified selected material with other endpoints, formulations, trials or person/eye/measurement units
- Remaining uncertainty: External abstract, full text, registration, protocol and SAP unread; no new calculation, content review or clinical checks
- Referenced methods: Retain the production copy of existing methodology application records and methodology linkage; full definition review and official certification are incomplete
- Related sources: R01

### N15 · Are first registration posting and primary-completion dates distinguished?

Verification status: Partly verified  
Reading scope: Summary read; related external material unread

- Current findings: NCT07111312 was first posted on 2025-08-08; primary completion was 2024-05-10. The original text describes retrospective registration after completion, which cannot support prospective registration.
- Why unverified: Display preserved-summary information, scope and direct gaps in production; this is not completed content review or a new clinical assessment
- Reason for missing information: Do not newly calculate the date gap or promote retrospective registration to prerecruitment planning.
- Required materials and conditions: NCT07111312, first posting, completion, original plans and history
- Materials to obtain first: Registration history, prerecruitment plans and completion records
- Further research: Display completion, registration and paper events separately
- Conditions for verification: NCT07111312, first posting, completion, original plans and history; preserve original values, direct observations, scope and gaps without creating new effects, assessments, calculations or independent certification
- Why this condition is needed: Production condition exposing direct original material, formulation, comparison, denominators and gaps for the selected endpoint
- Application exceptions: Do not fill unverified selected material with other endpoints, formulations, trials or person/eye/measurement units
- Remaining uncertainty: External abstract, full text, registration, protocol and SAP unread; no new calculation, content review or clinical checks
- Referenced methods: Retain the production copy of existing methodology application records and methodology linkage; full definition review and official certification are incomplete
- Related sources: R01

### N16 · Do original primary/secondary descriptions differ from independently prespecified plans?

Verification status: Partly verified  
Reading scope: Summary read; related external material unread

- Current findings: The preserved summary calls density primary and the hair-cycle ratio a prespecified secondary endpoint while also stating limits of retrospective registration.
- Why unverified: Display preserved-summary information, scope and direct gaps in production; this is not completed content review or a new clinical assessment
- Reason for missing information: Preserve the original hierarchy description without treating it as completed independent prospective verification. Original plans, changes and multiplicity are unread.
- Required materials and conditions: Endpoint hierarchy, protocol/SAP, multiplicity and change documents
- Materials to obtain first: Protocol/SAP, prerecruitment documents and change history
- Further research: Distinguish paper hierarchy descriptions from the verified scope of independent prospective plans
- Conditions for verification: Endpoint hierarchy, protocol/SAP, multiplicity and change documents; preserve original values, direct observations, scope and gaps without creating new effects, assessments, calculations or independent certification
- Why this condition is needed: Production condition exposing direct original material, formulation, comparison, denominators and gaps for the selected endpoint
- Application exceptions: Do not fill unverified selected material with other endpoints, formulations, trials or person/eye/measurement units
- Remaining uncertainty: External abstract, full text, registration, protocol and SAP unread; no new calculation, content review or clinical checks
- Referenced methods: Retain the production copy of existing methodology application records and methodology linkage; full definition review and official certification are incomplete
- Related sources: R01

### N17 · Does TrichoScan density mean visibly fuller hair?

Verification status: Partly verified  
Reading scope: Summary read; related external material unread

- Current findings: The original text distinguishes TrichoScan hair counts from a patient judging hair to look fuller. The separate appearance subclaim has grade ?.
- Why unverified: Display preserved-summary information, scope and direct gaps in production; this is not completed content review or a new clinical assessment
- Reason for missing information: Do not fill appearance, perception, satisfaction or treatment success with a positive density result or newly change that subclaim assessment.
- Required materials and conditions: Direct appearance, satisfaction, perception and function endpoints
- Materials to obtain first: Direct patient-centered appearance, satisfaction and function material
- Further research: Distinguish device measurements from gaps in the separate appearance question
- Conditions for verification: Direct appearance, satisfaction, perception and function endpoints; preserve original values, direct observations, scope and gaps without creating new effects, assessments, calculations or independent certification
- Why this condition is needed: Production condition exposing direct original material, formulation, comparison, denominators and gaps for the selected endpoint
- Application exceptions: Do not fill unverified selected material with other endpoints, formulations, trials or person/eye/measurement units
- Remaining uncertainty: External abstract, full text, registration, protocol and SAP unread; no new calculation, content review or clinical checks
- Referenced methods: Retain the production copy of existing methodology application records and methodology linkage; full definition review and official certification are incomplete
- Related sources: R01

### N18 · Was a finished-product effect extended to ingredients or other hair supplements?

Verification status: Partly verified  
Reading scope: Summary read; related external material unread

- Current findings: The original advertising interpretation says ingredients, formulations and populations vary by product, so Olistic results cannot become effects of Viviscal, Nutrafol or all hair supplements.
- Why unverified: Display preserved-summary information, scope and direct gaps in production; this is not completed content review or a new clinical assessment
- Reason for missing information: Do not create ingredient-specific benefits, product equivalence or recommendations for other brands. Full original ingredient specifications are also absent from the summary.
- Required materials and conditions: Direct comparisons for this product, other formulations and individual ingredients
- Materials to obtain first: Direct comparisons by finished product, formulation and ingredient
- Further research: Preserve applicability boundaries between this product and other product/ingredient questions
- Conditions for verification: Direct comparisons for this product, other formulations and individual ingredients; preserve original values, direct observations, scope and gaps without creating new effects, assessments, calculations or independent certification
- Why this condition is needed: Production condition exposing direct original material, formulation, comparison, denominators and gaps for the selected endpoint
- Application exceptions: Do not fill unverified selected material with other endpoints, formulations, trials or person/eye/measurement units
- Remaining uncertainty: External abstract, full text, registration, protocol and SAP unread; no new calculation, content review or clinical checks
- Referenced methods: Retain the production copy of existing methodology application records and methodology linkage; full definition review and official certification are incomplete
- Related sources: R01

### N19 · Does six-month efficacy mean persistence after completion or prevention of all hair loss?

Verification status: Unverified  
Reading scope: Summary read; related external material unread

- Current findings: The original trial lasted six months/180 days; the original counterpoint says it does not establish durability or effects of other formulations.
- Why unverified: Display preserved-summary information, scope and direct gaps in production; this is not completed content review or a new clinical assessment
- Reason for missing information: Do not fill postcompletion persistence, disease prevention, treatment of all hair loss or treatment substitution with numbers.
- Required materials and conditions: Postcompletion follow-up, long-term density and clinical outcomes
- Materials to obtain first: Postcompletion density and clinical-outcome follow-up
- Further research: Distinguish exposure-period results from direct postcompletion results
- Conditions for verification: Postcompletion follow-up, long-term density and clinical outcomes; preserve original values, direct observations, scope and gaps without creating new effects, assessments, calculations or independent certification
- Why this condition is needed: Production condition exposing direct original material, formulation, comparison, denominators and gaps for the selected endpoint
- Application exceptions: Do not fill unverified selected material with other endpoints, formulations, trials or person/eye/measurement units
- Remaining uncertainty: External abstract, full text, registration, protocol and SAP unread; no new calculation, content review or clinical checks
- Referenced methods: Retain the production copy of existing methodology application records and methodology linkage; full definition review and official certification are incomplete
- Related sources: R01

### N20 · Are the same trial, citation, registration and two subclaims independent replication?

Verification status: Partly verified  
Reading scope: Summary read; related external material unread

- Current findings: The original material links one trial in 106 people, one citation and NCT07111312. Density, hair-cycle ratios, days 90/180 and the appearance sibling row share the same report context.
- Why unverified: Display preserved-summary information, scope and direct gaps in production; this is not completed content review or a new clinical assessment
- Reason for missing information: Do not count the paper, registration, timepoints, two groups or sibling sheets as new independent trials/participants. Confirmed trial/participant counts remain unrecorded.
- Required materials and conditions: CT-OW-02, paper, registration, shared participants and timepoint linkage
- Materials to obtain first: Report, registration, measurement and participant-linkage material
- Further research: Distinguish endpoint/report slots from trial/participant units
- Conditions for verification: CT-OW-02, paper, registration, shared participants and timepoint linkage; preserve original values, direct observations, scope and gaps without creating new effects, assessments, calculations or independent certification
- Why this condition is needed: Production condition exposing direct original material, formulation, comparison, denominators and gaps for the selected endpoint
- Application exceptions: Do not fill unverified selected material with other endpoints, formulations, trials or person/eye/measurement units
- Remaining uncertainty: External abstract, full text, registration, protocol and SAP unread; no new calculation, content review or clinical checks
- Referenced methods: Retain the production copy of existing methodology application records and methodology linkage; full definition review and official certification are incomplete
- Related sources: R01

### N21 · Is there independent replication beyond one small manufacturer trial?

Verification status: Partly verified  
Reading scope: Summary read; related external material unread

- Current findings: The original rationale describes one trial in 106 people (53/53), the limitation of fewer than 200 participants and manufacturer-only evidence.
- Why unverified: Display preserved-summary information, scope and direct gaps in production; this is not completed content review or a new clinical assessment
- Reason for missing information: Do not turn the 200-person statement into an arbitrary passing sample size or new importance criterion. Do not newly certify independent replication or applicability to other conditions.
- Required materials and conditions: Actual independent replication of the same finished product, population and duration
- Materials to obtain first: Direct replication/applicability material for the same question
- Further research: Distinguish original sample-size limits from gaps in independent replication
- Conditions for verification: Actual independent replication of the same finished product, population and duration; preserve original values, direct observations, scope and gaps without creating new effects, assessments, calculations or independent certification
- Why this condition is needed: Production condition exposing direct original material, formulation, comparison, denominators and gaps for the selected endpoint
- Application exceptions: Do not fill unverified selected material with other endpoints, formulations, trials or person/eye/measurement units
- Remaining uncertainty: External abstract, full text, registration, protocol and SAP unread; no new calculation, content review or clinical checks
- Referenced methods: Retain the production copy of existing methodology application records and methodology linkage; full definition review and official certification are incomplete
- Related sources: R01

### N22 · Are research funding, publication fees and product/placebo support separated?

Verification status: Partly verified  
Reading scope: Summary read; related external material unread

- Current findings: The original text says Olistic Research Labs S.L. fully funded research and publication fees and supplied product and placebo.
- Why unverified: Display preserved-summary information, scope and direct gaps in production; this is not completed content review or a new clinical assessment
- Reason for missing information: Do not turn manufacturer support into public or independent support. Specific contracts, batches and other roles are unread.
- Required materials and conditions: Company funding, publication fees and product/placebo supply disclosures
- Materials to obtain first: Funding, publication-fee and product/placebo disclosures and contracts
- Further research: Display research costs, publication fees and product support separately
- Conditions for verification: Company funding, publication fees and product/placebo supply disclosures; preserve original values, direct observations, scope and gaps without creating new effects, assessments, calculations or independent certification
- Why this condition is needed: Production condition exposing direct original material, formulation, comparison, denominators and gaps for the selected endpoint
- Application exceptions: Do not fill unverified selected material with other endpoints, formulations, trials or person/eye/measurement units
- Remaining uncertainty: External abstract, full text, registration, protocol and SAP unread; no new calculation, content review or clinical checks
- Referenced methods: Retain the production copy of existing methodology application records and methodology linkage; full definition review and official certification are incomplete
- Related sources: R01

### N23 · Are sponsor, responsible party and company-employed author distinguished?

Verification status: Partly verified  
Reading scope: Summary read; related external material unread

- Current findings: The original text says the company was sponsor/responsible party and Manuel Sáez Moya was affiliated with the company.
- Why unverified: Display preserved-summary information, scope and direct gaps in production; this is not completed content review or a new clinical assessment
- Reason for missing information: Do not turn responsibility or employee authorship into independent operations. Full individual contributions, data control and publication authority are unverified.
- Required materials and conditions: Responsibility, registrant, author relationships/contributions and data rights
- Materials to obtain first: Registrant, author COI, contribution and authority disclosures
- Further research: Distinguish support, responsibility, employees and individual roles
- Conditions for verification: Responsibility, registrant, author relationships/contributions and data rights; preserve original values, direct observations, scope and gaps without creating new effects, assessments, calculations or independent certification
- Why this condition is needed: Production condition exposing direct original material, formulation, comparison, denominators and gaps for the selected endpoint
- Application exceptions: Do not fill unverified selected material with other endpoints, formulations, trials or person/eye/measurement units
- Remaining uncertainty: External abstract, full text, registration, protocol and SAP unread; no new calculation, content review or clinical checks
- Referenced methods: Retain the production copy of existing methodology application records and methodology linkage; full definition review and official certification are incomplete
- Related sources: R01

### N24 · Were all outsourced analysis, medical writing and editing roles verified?

Verification status: Unverified  
Reading scope: Summary read; related external material unread

- Current findings: Research/publication costs, product/placebo supply and some responsibility/affiliation information are preserved.
- Why unverified: Display preserved-summary information, scope and direct gaps in production; this is not completed content review or a new clinical assessment
- Reason for missing information: Do not certify unmentioned outsourced analysis, medical writing, editing or other roles as absent or fully independent.
- Required materials and conditions: Actual disclosures of analysis, writing, editing and other support
- Materials to obtain first: Full support, analysis, writing, data and publication-role disclosures
- Further research: Record reported involvement separately from unverified roles
- Conditions for verification: Actual disclosures of analysis, writing, editing and other support; preserve original values, direct observations, scope and gaps without creating new effects, assessments, calculations or independent certification
- Why this condition is needed: Production condition exposing direct original material, formulation, comparison, denominators and gaps for the selected endpoint
- Application exceptions: Do not fill unverified selected material with other endpoints, formulations, trials or person/eye/measurement units
- Remaining uncertainty: External abstract, full text, registration, protocol and SAP unread; no new calculation, content review or clinical checks
- Referenced methods: Retain the production copy of existing methodology application records and methodology linkage; full definition review and official certification are incomplete
- Related sources: R01

### N25 · Are noncollection and nonreporting of minor adverse events distinguished?

Verification status: Partly verified  
Reading scope: Summary read; related external material unread

- Current findings: The original research explanation and safety detail explicitly say minor adverse events were not collected at all.
- Why unverified: Display preserved-summary information, scope and direct gaps in production; this is not completed content review or a new clinical assessment
- Reason for missing information: Do not turn noncollection into zero events, no problems or good general tolerability. Parent safety Unknown is the original record.
- Required materials and conditions: Harm collection/classification, group observations and exposure denominators
- Materials to obtain first: Full harm-collection scope, group events and exposure tables
- Further research: Distinguish noncollection from observed zero events and nonreporting
- Conditions for verification: Harm collection/classification, group observations and exposure denominators; preserve original values, direct observations, scope and gaps without creating new effects, assessments, calculations or independent certification
- Why this condition is needed: Supplementary condition exposing harm-collection, denominator and follow-up limits separately from efficacy
- Application exceptions: Do not fill unverified selected material with other endpoints, formulations, trials or person/eye/measurement units
- Remaining uncertainty: External abstract, full text, registration, protocol and SAP unread; no new calculation, content review or clinical checks
- Referenced methods: Retain the production copy of existing methodology application records and methodology linkage; full definition review and official certification are incomplete
- Related sources: R01

### N26 · Are serious-harm, discontinuation and relatedness material available?

Verification status: Unverified  
Reading scope: Summary read; related external material unread

- Current findings: The summary explicitly states minor adverse events were not collected and this trial alone cannot establish safety.
- Why unverified: Display preserved-summary information, scope and direct gaps in production; this is not completed content review or a new clinical assessment
- Reason for missing information: Full serious-event tables, group denominators, relatedness and discontinuation material are absent from the summary; do not create absence or safety equivalence.
- Required materials and conditions: Serious events, discontinuation/reasons, relatedness, control and denominators
- Materials to obtain first: Serious-event, discontinuation, relatedness and group-denominator material
- Further research: Display collection limits separately from gaps in other harm material
- Conditions for verification: Serious events, discontinuation/reasons, relatedness, control and denominators; preserve original values, direct observations, scope and gaps without creating new effects, assessments, calculations or independent certification
- Why this condition is needed: Supplementary condition exposing harm-collection, denominator and follow-up limits separately from efficacy
- Application exceptions: Do not fill unverified selected material with other endpoints, formulations, trials or person/eye/measurement units
- Remaining uncertainty: External abstract, full text, registration, protocol and SAP unread; no new calculation, content review or clinical checks
- Referenced methods: Retain the production copy of existing methodology application records and methodology linkage; full definition review and official certification are incomplete
- Related sources: R01

### N27 · Can long-term/rare harms or tolerability in other populations be judged?

Verification status: Unverified  
Reading scope: Summary read; related external material unread

- Current findings: The original trial lasted six months and harm collection was incomplete.
- Why unverified: Display preserved-summary information, scope and direct gaps in production; this is not completed content review or a new clinical assessment
- Reason for missing information: Do not fill absence of long-term/rare harms, safety in other sexes/hair-loss conditions/ages or general tolerability.
- Required materials and conditions: Long exposure, rare events, vulnerable populations and follow-up
- Materials to obtain first: Long-term/rare-event and population-specific exposure/harm material
- Further research: Distinguish short-term efficacy values from gaps in long-term safety
- Conditions for verification: Long exposure, rare events, vulnerable populations and follow-up; preserve original values, direct observations, scope and gaps without creating new effects, assessments, calculations or independent certification
- Why this condition is needed: Supplementary condition exposing harm-collection, denominator and follow-up limits separately from efficacy
- Application exceptions: Do not fill unverified selected material with other endpoints, formulations, trials or person/eye/measurement units
- Remaining uncertainty: External abstract, full text, registration, protocol and SAP unread; no new calculation, content review or clinical checks
- Referenced methods: Retain the production copy of existing methodology application records and methodology linkage; full definition review and official certification are incomplete
- Related sources: R01

### N28 · Are the actually read summary and external abstract/full text/registration/plans shown?

Verification status: Partly verified  
Reading scope: Summary read; related external material unread

- Current findings: The full preserved summary was actually read; the PubMed URL is linked as an original bibliographic reference.
- Why unverified: Display preserved-summary information, scope and direct gaps in production; this is not completed content review or a new clinical assessment
- Reason for missing information: External abstracts, full texts, registration, protocol/SAP, links and screens were not checked. Do not turn URL presence or historical original-text descriptions into new external reading or content review.
- Required materials and conditions: Preserved summary, citation URL and actual reading status by material
- Materials to obtain first: Original paper, registration and protocol/SAP
- Further research: Display summary reading and unread external material separately
- Conditions for verification: Preserved summary, citation URL and actual reading status by material; preserve original values, direct observations, scope and gaps without creating new effects, assessments, calculations or independent certification
- Why this condition is needed: Production condition exposing direct original material, formulation, comparison, denominators and gaps for the selected endpoint
- Application exceptions: Do not fill unverified selected material with other endpoints, formulations, trials or person/eye/measurement units
- Remaining uncertainty: External abstract, full text, registration, protocol and SAP unread; no new calculation, content review or clinical checks
- Referenced methods: Retain the production copy of existing methodology application records and methodology linkage; full definition review and official certification are incomplete
- Related sources: R01

### N29 · Are original history, parent values and linkage separated from production and review of existing content?

Verification status: Partly verified  
Reading scope: Summary read; related external material unread

- Current findings: Preserve Korean/English text, axes, the 2026-08-26 evidence date, empty correction/deliberation records and subclaims in the full original summary. Existing review-pending/production-eligibility indicators are historical.
- Why unverified: Display preserved-summary information, scope and direct gaps in production; this is not completed content review or a new clinical assessment
- Reason for missing information: Retain absent subclaim scores/status/axes; the evidence date is not a current review date. The existing review wait is not activated, content review remains incomplete, completion is false, new units are zero and final independent counts are unrecorded.
- Required materials and conditions: Korean/English text, axes, dates, corrections, existing selection and freeze/application
- Materials to obtain first: Original preserved summary, existing selection and freeze/application production events
- Further research: Record original assessment/corrections separately from production and review of existing content
- Conditions for verification: Korean/English text, axes, dates, corrections, existing selection and freeze/application; preserve original values, direct observations, scope and gaps without creating new effects, assessments, calculations or independent certification
- Why this condition is needed: Production condition exposing direct original material, formulation, comparison, denominators and gaps for the selected endpoint
- Application exceptions: Do not fill unverified selected material with other endpoints, formulations, trials or person/eye/measurement units
- Remaining uncertainty: External abstract, full text, registration, protocol and SAP unread; no new calculation, content review or clinical checks
- Referenced methods: Retain the production copy of existing methodology application records and methodology linkage; full definition review and official certification are incomplete
- Related sources: R01

## Evidence and sources

### R01

Sáez Moya M, et al. Efficacy and Safety of a Drinkable Nutraceutical in Premenopausal Women with Telogen Effluvium. Dermatol Ther (Heidelb). 2025. PMID: 41288927.

[PubMed](https://pubmed.ncbi.nlm.nih.gov/41288927/)

Materials actually read: Summary read; external abstracts, full texts, registration and plans unread  
Findings recorded in the summary: +27.31±2.61 versus +18.23±2.98 hairs/cm², P<0.01; 95% CI not reported  
Record level: Six-month TrichoScan hair density with the CT-OW-02 finished product; distinct from appearance, long-term outcomes and other products  
Independent replication: Two groups, days 90/180, endpoints, registration and sibling rows of one CT-OW-02; do not sum as independent replication

| Material | Public availability | Access status | Actually read | Notes |
|---|---|---|---|---|
| Stored summary | Summary read | Stored summary read | Summary read | Material slot; no certification of external acquisition/reading/link checks or independent-trial counts |
| External abstract | Not read | External material unread | Not read | Material slot; no certification of external acquisition/reading/link checks or independent-trial counts |
| External full text | Not read | External material unread | Not read | Material slot; no certification of external acquisition/reading/link checks or independent-trial counts |
| Original registration | Not read | External material unread | Not read | Material slot; no certification of external acquisition/reading/link checks or independent-trial counts |
| Protocol/SAP | Not read | External material unread | Not read | Material slot; no certification of external acquisition/reading/link checks or independent-trial counts |

## Review criteria and methods

These are Chamgap's own application conditions, informed by the relevant sections of official methodological guidance. They do not constitute official assessment-tool certification or a new efficacy score.

- M03 [Cochrane Handbook 6.5 (2024), chapter updated 2023-08](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03) · §3.1, §3.2.1–3.2.3, MECIR C5/C7/C13 · Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions. · Preserved methodological linkages reused for production; no current methodological reassessment or external link checks, and historical quality review is not inherited
- M04 [Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04) · §4.5, §4.6.1–4.6.3, MECIR C42 · Distinguish studies from reports and link them; do not omit a study solely because results are unreported. · Preserved methodological linkages reused for production; no current methodological reassessment or external link checks, and historical quality review is not inherited
- M08 [Cochrane Handbook 6.5 (2024), chapter updated 2019-10](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08) · §8.1–8.2.3, Table 8.2.a · Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting. · Preserved methodological linkages reused for production; no current methodological reassessment or external link checks, and historical quality review is not inherited
- M15 [Cochrane Handbook 6.5 (2024), chapter updated 2023-08](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15) · §15.2.4, §15.3.1–15.3.3 · Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision. · Preserved methodological linkages reused for production; no current methodological reassessment or external link checks, and historical quality review is not inherited
- M19 [Cochrane Handbook 6.5 (2024), chapter updated 2019-10](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19) · §19.1.2, §19.2.1–19.2.4 · Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates. · Preserved methodological linkages reused for production; no current methodological reassessment or external link checks, and historical quality review is not inherited

## What the statuses mean

- Partly verified: Some information exists in the preserved review summary; detailed original materials remain unverified. This does not certify a passed review or clinical efficacy.
- Unverified: Detailed materials for the selected condition could not be established within the stored scope; this does not mean zero effect, zero studies or safety
- Review incomplete: Review of existing content incomplete
- Met: Use only within the relevant conditions after existing content review; no automatic designation in this preparation
- Not reported: Distinguish only within materials actually read; do not turn unread external materials into unreported findings
- Inaccessible: Not applied during this preparation because actual access was not tested
- Not applicable: Use with a reason for non-applicability based on an explicit question boundary
- Conflicting data: Judge after actual material comparison; review was not performed during this preparation
- Insufficient evidence for the conditions: Do not use as a clinical grade encompassing currently unread materials

## Change history

2026-10-12 · Public page/materials 1.0. Public pages and materials were created from the existing 29 items. No new clinical search, verification-status change or scoring was performed.