# Olistic Women · Direct-evidence gaps for visibly fuller hair Verdict 2956 · Evidence Check Stored-material review date: Not recorded Original evidence cut-off: 2026-08-26 Review-criteria version: 1.0 Public page/material preparation date: 2026-10-12 Clinical papers were not read directly; existing review summaries were checked. No new clinical-literature search was performed. Unverified does not mean that research is absent or that there is no effect. ## Assessment scope - Population: 106 premenopausal women diagnosed with telogen effluvium, allocated 53/53. Detailed diagnosis/baseline and appearance-response/analysis populations are unverified. - Ingredient, formulation and route: Olistic Women drinkable multi-ingredient nutraceutical - Dose: Original trial exposure: one 25-mL finished-product vial daily for six months. Actual adherence, ingredient quantities and other exposures are unverified; this is not use guidance. - Comparator: Manufacturer-supplied placebo. Original composition/appearance, actual common management/concurrent exposure and assessor blinding details are unverified. - Measured outcome: The selection concerns visibly fuller hair. Retain original grade ? and the note that appearance was not primary. Direct appearance/patient-perception definitions, scales, photographs/assessment, denominators, effects and intervals are unverified. - Duration: Original six-month instrumental trial and day-90/day-180 results context. Actual appearance-assessment timing and post-discontinuation/long-term durability are unverified. - Questions outside this scope: Transferring TrichoScan density, cycle-ratio and day-90/day-180 signals into visible appearance/patient-perception effects; Subtracting product/placebo changes to create a new net effect, treating ± as a CI or converting density into appearance scores/response rates; Copying/summing 106/53 allocation or measurement areas/time points as valid appearance denominators or total participants; Promoting retrospective-registration results to prospective registration or current plan certification; Changing minor-AE noncollection into all harms zero or good tolerability/long-term safety; Generalizing to other products/ingredients, hair-loss types/populations or long-term/post-discontinuation effects; Instructions for product consumption, hair/cosmetic care or hair-loss/nutrition treatment/substitution ## Checklist items ### N01 · What are the selected original question and assessment record? Verification status: Partly verified Reading scope: Summary read; external materials not read - Current findings: The selected original question and assessment record concern visibly fuller hair. Parent and sibling TrichoScan hair-density questions concern a different endpoint. - Why unverified: Original summary information is linked for production; clinical verification, condition fulfillment and content review are not complete. No new independent-claim certification, structural split or invented main assessment was created. - Reason for missing information: No new independent-claim certification, structural split or invented main assessment was created. - Required materials and conditions: Original visibly fuller hair wording, Korean/English texts and link - Materials to obtain first: Preserved selected assessment record and complete parent summary - Further research: If the question changes, retain original wording, the previous complete version and the change event. - Conditions for verification: Link Original visibly fuller hair wording, Korean/English texts and link to the actual finished product, population, endpoint, timing, denominator/analysis and reading scope; distinguish unverified matters. - Why this condition is needed: Production condition to record the actual scope of Original visibly fuller hair wording, Korean/English texts and link. - Application exceptions: Do not count instrumental and appearance questions in one report as new independent trials or participants. - Remaining uncertainty: Within the production scope of the preserved summary. No new independent-claim certification, structural split or invented main assessment was created. - Referenced methods: Question-clarification principles in M03 §3.1, §3.2.1–3.2.4; detailed separation rules are our own design - Related sources: R01 ### N02 · How do the subclaim ? and parent C50, axes and history differ? Verification status: Partly verified Reading scope: Summary read; external materials not read - Current findings: The subclaim is ? with the note that the primary endpoint was not appearance. Score/status/axes keys are absent. Parent C50, Unknown and B/S/R1/I0/E+/B1 with precision null are parent context. - Why unverified: Original summary information is linked for production; clinical verification, condition fulfillment and content review are not complete. Selected-row score, status and axes are null; do not fill them with parent score or grade. - Reason for missing information: Selected-row score, status and axes are null; do not fill them with parent score or grade. - Required materials and conditions: Subclaim grade/note, absent score/status/axes and actual parent values - Materials to obtain first: Original subclaim record and parent grade/score/axes and assessment history - Further research: Distinguish actual evidence-update events from preservation of original values. - Conditions for verification: Link Subclaim grade/note, absent score/status/axes and actual parent values to the actual finished product, population, endpoint, timing, denominator/analysis and reading scope; distinguish unverified matters. - Why this condition is needed: Production condition to record the actual scope of Subclaim grade/note, absent score/status/axes and actual parent values. - Application exceptions: Do not transfer parent measured-density C50 or historical cross-checks into a new appearance assessment, score or completed content review. - Remaining uncertainty: Within the production scope of the preserved summary. Selected-row score, status and axes are null; do not fill them with parent score or grade. - Referenced methods: M03 §3.1, §3.2.1–3.2.4 question-clarification principles; detailed separation rules are internally designed; M04 §4.5, §4.6.3; limits of this material conversion follow the review scope and internal design - Related sources: R01 ### N03 · Which selected population of women entered the finished-product trial? Verification status: Partly verified Reading scope: Summary read; external materials not read - Current findings: CT-OW-02 was a multicenter trial in 106 premenopausal women diagnosed with telogen effluvium. - Why unverified: Original summary information is linked for production; clinical verification, condition fulfillment and content review are not complete. Age, diagnostic criteria, acute/chronic course, baseline hair loss, nutritional status, recruitment/exclusion and representativeness details are unverified. - Reason for missing information: Age, diagnostic criteria, acute/chronic course, baseline hair loss, nutritional status, recruitment/exclusion and representativeness details are unverified. - Required materials and conditions: Premenopausal status, telogen-effluvium diagnosis and actual recruitment/selection - Materials to obtain first: Original diagnostic/selection criteria, baseline characteristics and recruitment flow - Further research: Distinguish other-population material by actual diagnosis, menopausal status, baseline characteristics and selection. - Conditions for verification: Link Premenopausal status, telogen-effluvium diagnosis and actual recruitment/selection to the actual finished product, population, endpoint, timing, denominator/analysis and reading scope; distinguish unverified matters. - Why this condition is needed: Production condition to record the actual scope of Premenopausal status, telogen-effluvium diagnosis and actual recruitment/selection. - Application exceptions: Do not generalize to all female hair loss, men, postmenopausal women, other hair-loss types or deficiency populations. - Remaining uncertainty: Within the production scope of the preserved summary. Age, diagnostic criteria, acute/chronic course, baseline hair loss, nutritional status, recruitment/exclusion and representativeness details are unverified. - Referenced methods: M03 §3.2.1; detailed population conditions are Chamgap's own design - Related sources: R01 ### N04 · What material describes baseline appearance, hair loss and diagnosis? Verification status: Partly verified Reading scope: Summary read; external materials not read - Current findings: The original summary records telogen-effluvium diagnosis and TrichoScan results without providing direct selected appearance-assessment material. - Why unverified: Original summary information is linked for production; clinical verification, condition fulfillment and content review are not complete. Diagnostic methods, differential assessment, baseline photographs/appearance, patient burden, duration and mixed diagnoses are unverified. - Reason for missing information: Diagnostic methods, differential assessment, baseline photographs/appearance, patient burden, duration and mixed diagnoses are unverified. - Required materials and conditions: Telogen-effluvium definition, baseline appearance and diagnostic/differential assessment - Materials to obtain first: Original diagnosis, baseline appearance/symptoms and assessment criteria - Further research: Record actual baseline diagnosis and starting appearance when appearance-change material becomes available. - Conditions for verification: Link Telogen-effluvium definition, baseline appearance and diagnostic/differential assessment to the actual finished product, population, endpoint, timing, denominator/analysis and reading scope; distinguish unverified matters. - Why this condition is needed: Production condition to record the actual scope of Telogen-effluvium definition, baseline appearance and diagnostic/differential assessment. - Application exceptions: Do not create clinical hair-loss severity, baseline perception or differential diagnoses from TrichoScan numbers alone. - Remaining uncertainty: Within the production scope of the preserved summary. Diagnostic methods, differential assessment, baseline photographs/appearance, patient burden, duration and mixed diagnoses are unverified. - Referenced methods: M03 §3.2.1; detailed population conditions are Chamgap design; M08 Table 8.2.a, M03 §3.2.4; Chamgap adaptation - Related sources: R01 ### N05 · What are the finished product and ingredient scope? Verification status: Partly verified Reading scope: Summary read; external materials not read - Current findings: The original product is Olistic Women drinkable multi-ingredient nutraceutical. The manufacturer is recorded as supplying trial product and placebo. - Why unverified: Original summary information is linked for production; clinical verification, condition fulfillment and content review are not complete. Ingredient identities/quantities, batch, standardization, packaging/form and individual-ingredient effects are unverified. - Reason for missing information: Ingredient identities/quantities, batch, standardization, packaging/form and individual-ingredient effects are unverified. - Required materials and conditions: Olistic Women drinkable multi-ingredient finished product, formulation and composition - Materials to obtain first: Trial finished-product composition, batch, formulation and supply records - Further research: If material is provided, distinguish the finished product from individual ingredients and other formulations. - Conditions for verification: Link Olistic Women drinkable multi-ingredient finished product, formulation and composition to the actual finished product, population, endpoint, timing, denominator/analysis and reading scope; distinguish unverified matters. - Why this condition is needed: Production condition to record the actual scope of Olistic Women drinkable multi-ingredient finished product, formulation and composition. - Application exceptions: Do not fill in unrecorded biotin/vitamins/botanicals or attribute an effect to an individual ingredient. - Remaining uncertainty: Within the production scope of the preserved summary. Ingredient identities/quantities, batch, standardization, packaging/form and individual-ingredient effects are unverified. - Referenced methods: M03 §3.2.2–3.2.3; reverse labeling and test adaptations are Chamgap's own design - Related sources: R01 ### N06 · What were the original trial exposure and actual implementation? Verification status: Partly verified Reading scope: Summary read; external materials not read - Current findings: Original product information describes a finished-product trial of one 25-mL vial daily for six months. This preserves trial exposure. - Why unverified: Original summary information is linked for production; clinical verification, condition fulfillment and content review are not complete. Actual adherence, cumulative exposure, stopping/changes, ingredients per vial and other-dose comparisons are unverified. - Reason for missing information: Actual adherence, cumulative exposure, stopping/changes, ingredients per vial and other-dose comparisons are unverified. - Required materials and conditions: One 25-mL vial daily for six months and actual adherence/exposure - Materials to obtain first: Actual product exposure, adherence and discontinuation records - Further research: Distinguish nominal exposure from actual implementation in subsequent material. - Conditions for verification: Link One 25-mL vial daily for six months and actual adherence/exposure to the actual finished product, population, endpoint, timing, denominator/analysis and reading scope; distinguish unverified matters. - Why this condition is needed: Production condition to record the actual scope of One 25-mL vial daily for six months and actual adherence/exposure. - Application exceptions: Do not write consumption, product-selection, dosing, dose-conversion or treatment instructions. - Remaining uncertainty: Within the production scope of the preserved summary. Actual adherence, cumulative exposure, stopping/changes, ingredients per vial and other-dose comparisons are unverified. - Referenced methods: M03 §§3.2.2–3.2.3; reverse-direction labels and assessment adaptation are Chamgap-designed; M03 §§3.2.1–3.2.4; dose, durability and effect-modification details are Chamgap-designed - Related sources: R01 ### N07 · What were the placebo and common conditions? Verification status: Partly verified Reading scope: Summary read; external materials not read - Current findings: CT-OW-02 was placebo-controlled; the company is recorded as supplying product and placebo. - Why unverified: Original summary information is linked for production; clinical verification, condition fulfillment and content review are not complete. Placebo ingredients/calories, appearance/taste matching, distribution/adherence and differences in common management are unverified. - Reason for missing information: Placebo ingredients/calories, appearance/taste matching, distribution/adherence and differences in common management are unverified. - Required materials and conditions: Manufacturer-supplied placebo, actual composition/appearance and comparison direction - Materials to obtain first: Placebo composition, common conditions and actual exposure/blinding material - Further research: Distinguish the actual product/placebo contrast from comparisons with other ingredients. - Conditions for verification: Link Manufacturer-supplied placebo, actual composition/appearance and comparison direction to the actual finished product, population, endpoint, timing, denominator/analysis and reading scope; distinguish unverified matters. - Why this condition is needed: Production condition to record the actual scope of Manufacturer-supplied placebo, actual composition/appearance and comparison direction. - Application exceptions: Do not change placebo into no treatment or an unrecorded active comparator. - Remaining uncertainty: Within the production scope of the preserved summary. Placebo ingredients/calories, appearance/taste matching, distribution/adherence and differences in common management are unverified. - Referenced methods: M03 §3.2.2–3.2.3; Reverse-direction labels and assessment adaptation are Chamgap design; M03 §3.2.3 and M08 §8.2.2–8.2.3; Chamgap application - Related sources: R01 ### N08 · What were randomization and actual analysis scopes? Verification status: Partly verified Reading scope: Summary read; external materials not read - Current findings: The original trial randomized 106 participants, 53/53. Historical wording also says random-sequence and allocation-concealment methods were not confirmed in the public paper. - Why unverified: Original summary information is linked for production; clinical verification, condition fulfillment and content review are not complete. Actual completion and appearance/instrumental analysis denominators, original sequence/concealment methods and flow remain unread. - Reason for missing information: Actual completion and appearance/instrumental analysis denominators, original sequence/concealment methods and flow remain unread. - Required materials and conditions: 106 participants, 53/53 allocation, sequence/concealment and completion/analysis - Materials to obtain first: Allocation methods, group flow and actual endpoint-specific analysis n - Further research: If original material is provided, distinguish allocation from actual completion/analysis and measurement level. - Conditions for verification: Link 106 participants, 53/53 allocation, sequence/concealment and completion/analysis to the actual finished product, population, endpoint, timing, denominator/analysis and reading scope; distinguish unverified matters. - Why this condition is needed: Production condition to record the actual scope of 106 participants, 53/53 allocation, sequence/concealment and completion/analysis. - Application exceptions: Do not copy 53/53 as verified analysis denominators for every time point/appearance endpoint or assign new methodological-defect scores. - Remaining uncertainty: Within the production scope of the preserved summary. Actual completion and appearance/instrumental analysis denominators, original sequence/concealment methods and flow remain unread. - Referenced methods: M08 §8.1–8.2.3; own application; M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; design-specific adaptation is our own design - Related sources: R01 ### N09 · What were double-blinding and appearance-assessor conditions? Verification status: Partly verified Reading scope: Summary read; external materials not read - Current findings: The original design was a multicenter double-blind placebo-controlled randomized trial. - Why unverified: Original summary information is linked for production; clinical verification, condition fulfillment and content review are not complete. Who was blinded, product distinguishability, instrumental/appearance/photograph assessors and unblinding timing are unverified. - Reason for missing information: Who was blinded, product distinguishability, instrumental/appearance/photograph assessors and unblinding timing are unverified. - Required materials and conditions: Participants/measurers, photograph/appearance reading and maintained blinding - Materials to obtain first: Blinding, reading, photograph/appearance methods and actual implementation - Further research: Record patient/independent-assessor blinding and consistent assessment conditions in appearance material. - Conditions for verification: Link Participants/measurers, photograph/appearance reading and maintained blinding to the actual finished product, population, endpoint, timing, denominator/analysis and reading scope; distinguish unverified matters. - Why this condition is needed: Production condition to record the actual scope of Participants/measurers, photograph/appearance reading and maintained blinding. - Application exceptions: Do not confirm separate appearance assessment or blinding of every assessor from the design label alone. - Remaining uncertainty: Within the production scope of the preserved summary. Who was blinded, product distinguishability, instrumental/appearance/photograph assessors and unblinding timing are unverified. - Referenced methods: M08 Table 8.2.a and M03 §3.2.4; Chamgap adaptation; M08 §§8.1–8.2.3; Chamgap adaptation - Related sources: R01 ### N10 · What were concurrent hair care, treatment and natural course? Verification status: Unverified Reading scope: Summary read; external materials not read - Current findings: The summary records instrumental results for a particular finished product and placebo. - Why unverified: Direct definitions, values and material needed within the preserved-summary/unread-external scope are unverified. Concurrent treatment/nutrition/hair care, cosmetic/styling changes, lifestyle, natural course and group differences are unverified. - Reason for missing information: Concurrent treatment/nutrition/hair care, cosmetic/styling changes, lifestyle, natural course and group differences are unverified. - Required materials and conditions: Washing/cosmetic care, hair-loss management, medication, nutrition and natural recovery - Materials to obtain first: Original common/restricted conditions, concurrent exposure and actual implementation - Further research: Distinguish finished-product exposure from concurrent management/natural course in later appearance material. - Conditions for verification: Link Washing/cosmetic care, hair-loss management, medication, nutrition and natural recovery to the actual finished product, population, endpoint, timing, denominator/analysis and reading scope; distinguish unverified matters. - Why this condition is needed: Production condition to record the actual scope of Washing/cosmetic care, hair-loss management, medication, nutrition and natural recovery. - Application exceptions: Do not write new treatment, washing/cosmetic or hair-care methods or calculate natural recovery. - Remaining uncertainty: Within the production scope of the preserved summary. Concurrent treatment/nutrition/hair care, cosmetic/styling changes, lifestyle, natural course and group differences are unverified. - Referenced methods: M03 §3.2.3, M08 §8.2.2–8.2.3; Chamgap adaptation - Related sources: R01 ### N11 · What is the direct endpoint for visibly fuller hair? Verification status: Unverified Reading scope: Summary read; external materials not read - Current findings: The original subclaim note says appearance was not the primary endpoint. The parent distinguishes TrichoScan counts from patient perception. - Why unverified: Direct definitions, values and material needed within the preserved-summary/unread-external scope are unverified. Appearance definition, observer/patient judgment, actual assessment and scale/categories are unverified. - Reason for missing information: Appearance definition, observer/patient judgment, actual assessment and scale/categories are unverified. - Required materials and conditions: Visible fullness definition, observer and patient perception - Materials to obtain first: Direct appearance/patient-perception definitions, results and methods - Further research: Report actual appearance assessor, definition, timing and denominator separately from instrumental counts. - Conditions for verification: Link Visible fullness definition, observer and patient perception to the actual finished product, population, endpoint, timing, denominator/analysis and reading scope; distinguish unverified matters. - Why this condition is needed: Production condition to record the actual scope of Visible fullness definition, observer and patient perception. - Application exceptions: Do not present density change or the question wording as observed appearance improvement. - Remaining uncertainty: Within the production scope of the preserved summary. Appearance definition, observer/patient judgment, actual assessment and scale/categories are unverified. - Referenced methods: M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are our own design; M08 Table 8.2.a, M03 §3.2.4; our own application - Related sources: R01 ### N12 · What are the appearance scale and units of visible change? Verification status: Unverified Reading scope: Summary read; external materials not read - Current findings: The summary provides no direct appearance-change score, unit or response category. - Why unverified: Direct definitions, values and material needed within the preserved-summary/unread-external scope are unverified. Photographic assessment/scale, overall appearance, observer agreement, assessment conditions and validity criteria are unverified. - Reason for missing information: Photographic assessment/scale, overall appearance, observer agreement, assessment conditions and validity criteria are unverified. - Required materials and conditions: Visible change, scale, photograph/assessment and direction - Materials to obtain first: Direct appearance scale, definitions, measurement/reading methods and results - Further research: State scale direction, observer and change definition in appearance material. - Conditions for verification: Link Visible change, scale, photograph/assessment and direction to the actual finished product, population, endpoint, timing, denominator/analysis and reading scope; distinguish unverified matters. - Why this condition is needed: Production condition to record the actual scope of Visible change, scale, photograph/assessment and direction. - Application exceptions: Do not convert hairs/cm² into appearance scores, fullness percentages or perceived change. - Remaining uncertainty: Within the production scope of the preserved summary. Photographic assessment/scale, overall appearance, observer agreement, assessment conditions and validity criteria are unverified. - Referenced methods: M08 Table 8.2.a, M03 §3.2.4; own application; M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific result adaptation is our own design - Related sources: R01 ### N13 · Is actual standardized-photograph or independent-assessment material available? Verification status: Unverified Reading scope: Summary read; external materials not read - Current findings: The original summary only provides the boundary that appearance assessment was not the primary endpoint. - Why unverified: Direct definitions, values and material needed within the preserved-summary/unread-external scope are unverified. Whether photographs were taken/read, lighting/angle/styling conditions, independent assessment, blinding, agreement and results are unverified. - Reason for missing information: Whether photographs were taken/read, lighting/angle/styling conditions, independent assessment, blinding, agreement and results are unverified. - Required materials and conditions: Photographs/independent observation, consistent conditions, blinding and judgment - Materials to obtain first: Original methods and actual direct photograph-assessment results - Further research: State assessment conditions, independence and judgment level in later appearance material. - Conditions for verification: Link Photographs/independent observation, consistent conditions, blinding and judgment to the actual finished product, population, endpoint, timing, denominator/analysis and reading scope; distinguish unverified matters. - Why this condition is needed: Production condition to record the actual scope of Photographs/independent observation, consistent conditions, blinding and judgment. - Application exceptions: Do not assert that photographic assessment existed or did not exist, or provide photography/hair-care procedures. - Remaining uncertainty: Within the production scope of the preserved summary. Whether photographs were taken/read, lighting/angle/styling conditions, independent assessment, blinding, agreement and results are unverified. - Referenced methods: M08 Table 8.2.a, M03 §3.2.4; internal application - Related sources: R01 ### N14 · What are the direct patient-perception, satisfaction and quality-of-life values? Verification status: Unverified Reading scope: Summary read; external materials not read - Current findings: The original reader answer distinguishes perceived visible fullness from instrumental counts. - Why unverified: Direct definitions, values and material needed within the preserved-summary/unread-external scope are unverified. Patient-reported fullness, satisfaction, burden/quality of life, response scales, denominators and effects are unverified. - Reason for missing information: Patient-reported fullness, satisfaction, burden/quality of life, response scales, denominators and effects are unverified. - Required materials and conditions: Distinguish patient perception, appearance/satisfaction and symptoms/quality of life - Materials to obtain first: Patient-centered outcomes, scales, response/analysis n and original results tables - Further research: Record instrumental counts, appearance observation, satisfaction and quality of life as separate endpoints. - Conditions for verification: Link Distinguish patient perception, appearance/satisfaction and symptoms/quality of life to the actual finished product, population, endpoint, timing, denominator/analysis and reading scope; distinguish unverified matters. - Why this condition is needed: Production condition to record the actual scope of Distinguish patient perception, appearance/satisfaction and symptoms/quality of life. - Application exceptions: Do not attribute positive density numbers to improved satisfaction or quality of life. - Remaining uncertainty: Within the production scope of the preserved summary. Patient-reported fullness, satisfaction, burden/quality of life, response scales, denominators and effects are unverified. - Referenced methods: M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are our own design; M08 Table 8.2.a, M03 §3.2.4; our own application - Related sources: R01 ### N15 · What are appearance-assessment timing and durability? Verification status: Unverified Reading scope: Summary read; external materials not read - Current findings: The original trial describes six months and day-90/day-180 instrumental results. Actual selected appearance measurement/follow-up is not separately provided. - Why unverified: Direct definitions, values and material needed within the preserved-summary/unread-external scope are unverified. Appearance-assessment timing, persistence, follow-up after stopping and long-term patient perception are unverified. - Reason for missing information: Appearance-assessment timing, persistence, follow-up after stopping and long-term patient perception are unverified. - Required materials and conditions: Days 90/180, six-month trial and actual appearance/post-discontinuation follow-up - Materials to obtain first: Direct appearance assessment by time point and post-discontinuation follow-up - Further research: Distinguish on-treatment measurement from post-discontinuation persistence by actual timing and denominator. - Conditions for verification: Link Days 90/180, six-month trial and actual appearance/post-discontinuation follow-up to the actual finished product, population, endpoint, timing, denominator/analysis and reading scope; distinguish unverified matters. - Why this condition is needed: Production condition to record the actual scope of Days 90/180, six-month trial and actual appearance/post-discontinuation follow-up. - Application exceptions: Do not use day-90/day-180 instrumental signals to fill appearance improvement, long-term maintenance or recurrence prevention. - Remaining uncertainty: Within the production scope of the preserved summary. Appearance-assessment timing, persistence, follow-up after stopping and long-term patient perception are unverified. - Referenced methods: M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are internally designed; M03 §3.2.1–3.2.4; dose, duration and effect-modification details are internally designed - Related sources: R01 ### N16 · What separate measurement is the TrichoScan endpoint? Verification status: Partly verified Reading scope: Summary read; external materials not read - Current findings: The primary endpoint was hair-density increase from baseline by TrichoScan phototrichoscopy. The original summary says this counted hairs/cm² rather than appearance or satisfaction. - Why unverified: Original summary information is linked for production; clinical verification, condition fulfillment and content review are not complete. Device/measurement site/area, image/hair-length conditions, repetition/reading and baseline values are unverified. - Reason for missing information: Device/measurement site/area, image/hair-length conditions, repetition/reading and baseline values are unverified. - Required materials and conditions: Phototrichoscopy, change from baseline density and hairs/cm² - Materials to obtain first: Instrumental methods, area/site and original density-results tables - Further research: Record hair counts, sites/areas and separate appearance/perception definitions together. - Conditions for verification: Link Phototrichoscopy, change from baseline density and hairs/cm² to the actual finished product, population, endpoint, timing, denominator/analysis and reading scope; distinguish unverified matters. - Why this condition is needed: Production condition to record the actual scope of Phototrichoscopy, change from baseline density and hairs/cm². - Application exceptions: Do not convert measured hair counts into total scalp hair count, thickness/appearance or clinical recovery. - Remaining uncertainty: Within the production scope of the preserved summary. Device/measurement site/area, image/hair-length conditions, repetition/reading and baseline values are unverified. - Referenced methods: M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are Chamgap's own design; M03 §3.2.4; Chamgap's own limits on extension - Related sources: R01 ### N17 · What are the original day-180 density-change values? Verification status: Partly verified Reading scope: Summary read; external materials not read - Current findings: Original day-180 density increases were product +27.31±2.61 versus placebo +18.23±2.98 hairs/cm², P<0.01. These concern the instrumental density endpoint. - Why unverified: Original summary information is linked for production; clinical verification, condition fulfillment and content review are not complete. The statistical meaning of ±, time-specific analysis n, baseline/final values and between-group effects/intervals are unverified. - Reason for missing information: The statistical meaning of ±, time-specific analysis n, baseline/final values and between-group effects/intervals are unverified. - Required materials and conditions: Product +27.31±2.61, placebo +18.23±2.98 hairs/cm² and P<.01 - Materials to obtain first: Original day-180 instrumental tables, variability/denominators and analysis methods - Further research: Link changes, group contrasts, variability and actual n separately in original results tables. - Conditions for verification: Link Product +27.31±2.61, placebo +18.23±2.98 hairs/cm² and P<.01 to the actual finished product, population, endpoint, timing, denominator/analysis and reading scope; distinguish unverified matters. - Why this condition is needed: Production condition to record the actual scope of Product +27.31±2.61, placebo +18.23±2.98 hairs/cm² and P<.01. - Application exceptions: Do not subtract the numbers to create a new net effect or appearance increase, or treat ± as a CI. - Remaining uncertainty: Within the production scope of the preserved summary. The statistical meaning of ±, time-specific analysis n, baseline/final values and between-group effects/intervals are unverified. - Referenced methods: M03 §3.2.4 and M15 §§15.3.1–15.3.3; question-specific outcome adaptation is Chamgap-designed; M04 §4.6.3 and M15 §§15.3.1–15.3.3; status separation is Chamgap-designed - Related sources: R01 ### N18 · What hierarchy applies to day-90 and hair-cycle-ratio results? Verification status: Partly verified Reading scope: Summary read; external materials not read - Current findings: The original counterview describes day-90/day-180 group differences and a prespecified secondary anagen-to-catagen/telogen ratio of 8.20:1→14.19:1 versus placebo 7.43:1→8.76:1, P<0.001. - Why unverified: Original summary information is linked for production; clinical verification, condition fulfillment and content review are not complete. Day-90 quantities, actual ratio timing/denominators, hierarchy/plan dates and intervals/adjustment are unverified. - Reason for missing information: Day-90 quantities, actual ratio timing/denominators, hierarchy/plan dates and intervals/adjustment are unverified. - Required materials and conditions: Qualitative day-90 difference, secondary cycle ratio and separate endpoint - Materials to obtain first: Original density/cycle-ratio tables by time point and plans/hierarchy - Further research: Distinguish density, cycle ratio and appearance endpoints, timing and hierarchy. - Conditions for verification: Link Qualitative day-90 difference, secondary cycle ratio and separate endpoint to the actual finished product, population, endpoint, timing, denominator/analysis and reading scope; distinguish unverified matters. - Why this condition is needed: Production condition to record the actual scope of Qualitative day-90 difference, secondary cycle ratio and separate endpoint. - Application exceptions: Do not transfer cycle ratios or qualitative day-90 findings into direct visible-fullness values, effects or duration. - Remaining uncertainty: Within the production scope of the preserved summary. Day-90 quantities, actual ratio timing/denominators, hierarchy/plan dates and intervals/adjustment are unverified. - Referenced methods: M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific result adaptation is our own design; M08 Table 8.2.a, M04 §4.6.3; own application - Related sources: R01 ### N19 · Are direct between-group appearance effects and CIs provided? Verification status: Unverified Reading scope: Summary read; external materials not read - Current findings: Density P values and absent CIs in the summary concern instrumental context. Direct selected appearance contrasts/CIs are not provided. - Why unverified: Direct definitions, values and material needed within the preserved-summary/unread-external scope are unverified. Appearance-score/response contrasts, baseline adjustment, models, variability and confidence intervals are unverified. - Reason for missing information: Appearance-score/response contrasts, baseline adjustment, models, variability and confidence intervals are unverified. - Required materials and conditions: Actual appearance contrast, numerator/scale, intervals and adjustment - Materials to obtain first: Direct appearance results, denominators, variability and models/intervals - Further research: If original appearance material is provided, link its measure, unit, population and estimated interval. - Conditions for verification: Link Actual appearance contrast, numerator/scale, intervals and adjustment to the actual finished product, population, endpoint, timing, denominator/analysis and reading scope; distinguish unverified matters. - Why this condition is needed: Production condition to record the actual scope of Actual appearance contrast, numerator/scale, intervals and adjustment. - Application exceptions: Do not calculate appearance effects, CIs or response rates from instrumental P values, ± or density changes. - Remaining uncertainty: Within the production scope of the preserved summary. Appearance-score/response contrasts, baseline adjustment, models, variability and confidence intervals are unverified. - Referenced methods: M08 §8.2.2, M15 §15.3.1; internal application; M15 §15.3.1–15.3.3; internal application - Related sources: R01 ### N20 · What are clinically important instrumental/appearance thresholds? Verification status: Unverified Reading scope: Summary read; external materials not read - Current findings: The original counterview says 95% CIs and a clinically important minimum hairs/cm² threshold were not reported. No separate direct appearance threshold is provided. - Why unverified: Direct definitions, values and material needed within the preserved-summary/unread-external scope are unverified. Validation connecting instrumental differences to visible/perceived change, minimum appearance importance and original prespecified criteria are unverified. - Reason for missing information: Validation connecting instrumental differences to visible/perceived change, minimum appearance importance and original prespecified criteria are unverified. - Required materials and conditions: Importance of hairs/cm² and direct visible/perceived-change criteria - Materials to obtain first: Validation linking instrumental and appearance/perception outcomes and importance criteria - Further research: Distinguish measure, population and prespecified/post-hoc importance criteria. - Conditions for verification: Link Importance of hairs/cm² and direct visible/perceived-change criteria to the actual finished product, population, endpoint, timing, denominator/analysis and reading scope; distinguish unverified matters. - Why this condition is needed: Production condition to record the actual scope of Importance of hairs/cm² and direct visible/perceived-change criteria. - Application exceptions: Do not establish meaningful visible recovery solely from positive P values or hairs/cm² increase size. - Remaining uncertainty: Within the production scope of the preserved summary. Validation connecting instrumental differences to visible/perceived change, minimum appearance importance and original prespecified criteria are unverified. - Referenced methods: M15 §§15.3.1–15.3.3; Chamgap adaptation - Related sources: R01 ### N21 · How do appearance-assessment denominators differ from 106 randomized participants? Verification status: Unverified Reading scope: Summary read; external materials not read - Current findings: The summary records 106 randomized participants, 53/53. Direct appearance-assessment/response denominators are not provided. - Why unverified: Direct definitions, values and material needed within the preserved-summary/unread-external scope are unverified. Instrumental/appearance completion, valid responses, analysis n, areas/repeated measurements and group correspondence are unverified. - Reason for missing information: Instrumental/appearance completion, valid responses, analysis n, areas/repeated measurements and group correspondence are unverified. - Required materials and conditions: 53/53 allocation, valid appearance/responses and actual analysis by time point - Materials to obtain first: Group flow, actual endpoint/time-specific denominators and response criteria - Further research: Distinguish people, measurement areas, time points and instrumental/appearance denominators. - Conditions for verification: Link 53/53 allocation, valid appearance/responses and actual analysis by time point to the actual finished product, population, endpoint, timing, denominator/analysis and reading scope; distinguish unverified matters. - Why this condition is needed: Production condition to record the actual scope of 53/53 allocation, valid appearance/responses and actual analysis by time point. - Application exceptions: Do not copy 53/53 allocation as appearance-results n or add measurement areas/time points as people. - Remaining uncertainty: Within the production scope of the preserved summary. Instrumental/appearance completion, valid responses, analysis n, areas/repeated measurements and group correspondence are unverified. - Referenced methods: M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; design-specific adaptations are Chamgap design - Related sources: R01 ### N22 · What records describe missingness, attrition and analysis populations? Verification status: Partly verified Reading scope: Summary read; external materials not read - Current findings: The original research explanation says missing-data handling details were not confirmed in the public paper. External papers/tables remain unread here. - Why unverified: Original summary information is linked for production; clinical verification, condition fulfillment and content review are not complete. Completion/dropout counts/reasons, ITT/PP, imputation/sensitivity, appearance-response selection and actual analysis are unverified. - Reason for missing information: Completion/dropout counts/reasons, ITT/PP, imputation/sensitivity, appearance-response selection and actual analysis are unverified. - Required materials and conditions: Instrumental/appearance analysis populations, missingness/attrition and supporting analyses - Materials to obtain first: Original flow, analysis populations, missingness/attrition and sensitivity material - Further research: Distinguish allocation, measurement, completion, response/analysis and missingness assumptions. - Conditions for verification: Link Instrumental/appearance analysis populations, missingness/attrition and supporting analyses to the actual finished product, population, endpoint, timing, denominator/analysis and reading scope; distinguish unverified matters. - Why this condition is needed: Production condition to record the actual scope of Instrumental/appearance analysis populations, missingness/attrition and supporting analyses. - Application exceptions: Do not change historical missing-data uncertainty into zero dropout, complete ITT or new defect counts/scores. - Remaining uncertainty: Within the production scope of the preserved summary. Completion/dropout counts/reasons, ITT/PP, imputation/sensitivity, appearance-response selection and actual analysis are unverified. - Referenced methods: M08 §8.2.2 and M15 §15.3.1: in-house application; M08 Table 8.2.a, M15 §15.3 and M19 §19.1.2–19.2.4: design-specific adaptation is in-house. - Related sources: R01 ### N23 · What actual prospective plans apply to appearance/instrumental endpoints? Verification status: Partly verified Reading scope: Summary read; external materials not read - Current findings: The original primary endpoint was TrichoScan density rather than appearance. The cycle ratio is described as prespecified secondary in the original summary. - Why unverified: Original summary information is linked for production; clinical verification, condition fulfillment and content review are not complete. Appearance-endpoint existence/hierarchy, original protocol/SAP dates, multiplicity, selective reporting and actual prespecification are unverified. - Reason for missing information: Appearance-endpoint existence/hierarchy, original protocol/SAP dates, multiplicity, selective reporting and actual prespecification are unverified. - Required materials and conditions: Instrumental primary endpoint, appearance hierarchy/plans and retrospective registration - Materials to obtain first: Registration history and protocol/SAP outcomes, hierarchy and analysis - Further research: If plans are provided, distinguish actual prospective/retrospective timing, endpoints and hierarchy. - Conditions for verification: Link Instrumental primary endpoint, appearance hierarchy/plans and retrospective registration to the actual finished product, population, endpoint, timing, denominator/analysis and reading scope; distinguish unverified matters. - Why this condition is needed: Production condition to record the actual scope of Instrumental primary endpoint, appearance hierarchy/plans and retrospective registration. - Application exceptions: Do not promote retrospective-registration outcomes to prospective registration or original prespecified-secondary wording to current plan verification. - Remaining uncertainty: Within the production scope of the preserved summary. Appearance-endpoint existence/hierarchy, original protocol/SAP dates, multiplicity, selective reporting and actual prespecification are unverified. - Referenced methods: M08 Table 8.2.a, M04 §4.6.3; Chamgap's own application - Related sources: R01 ### N24 · What original records give registration, posting and completion dates? Verification status: Partly verified Reading scope: Summary read; external materials not read - Current findings: The summary records NCT07111312 first posting 2025-08-08 and primary completion 2024-05-10, after-trial registration that cannot support prospective registration. - Why unverified: Original summary information is linked for production; clinical verification, condition fulfillment and content review are not complete. Current registration text, revision history, original plans and individual-endpoint/completion material are unread. - Reason for missing information: Current registration text, revision history, original plans and individual-endpoint/completion material are unread. - Required materials and conditions: NCT07111312, posting 2025-08-08 and completion 2024-05-10 - Materials to obtain first: Original registration/history, protocol/SAP and actual trial timeline - Further research: If material is provided, distinguish original dates, current reading and condition/assessment-change events. - Conditions for verification: Link NCT07111312, posting 2025-08-08 and completion 2024-05-10 to the actual finished product, population, endpoint, timing, denominator/analysis and reading scope; distinguish unverified matters. - Why this condition is needed: Production condition to record the actual scope of NCT07111312, posting 2025-08-08 and completion 2024-05-10. - Application exceptions: Do not calculate elapsed time or change retrospective/original-date history into a registration lookup performed here. - Remaining uncertainty: Within the production scope of the preserved summary. Current registration text, revision history, original plans and individual-endpoint/completion material are unread. - Referenced methods: M08 Table 8.2.a, M04 §4.6.3; Chamgap application; M04 §4.5, §4.6.3; limits to this material conversion reflect the review scope and Chamgap's own design - Related sources: R01 ### N25 · What are the report identity and actual preserved-summary locations? Verification status: Partly verified Reading scope: Summary read; external materials not read - Current findings: R01 is Sáez Moya M et al., 2025 CT-OW-02, Dermatol Ther (Heidelb), PMID 41288927, linked to the first original evidence and citation records. - Why unverified: Original summary information is linked for production; clinical verification, condition fulfillment and content review are not complete. DOI, PMCID, current external bibliography/full text and original appearance-results locations are not provided. - Reason for missing information: DOI, PMCID, current external bibliography/full text and original appearance-results locations are not provided. - Required materials and conditions: SáezMoya2025·CT-OW-02·PMID41288927 - Materials to obtain first: Original bibliography, full text and registration/product/population links - Further research: When bibliography is supplemented, preserve original wording, report identity and change events. - Conditions for verification: Link Sáez Moya 2025, CT-OW-02 and PMID 41288927 to the actual finished product, population, endpoint, timing, denominator/analysis and reading scope; distinguish unverified matters. - Why this condition is needed: Production condition to record the actual scope of Sáez Moya 2025, CT-OW-02 and PMID 41288927. - Application exceptions: Do not infer DOI/PMCID from PMID or create additional slots/trials from other-product reports. - Remaining uncertainty: Within the production scope of the preserved summary. DOI, PMCID, current external bibliography/full text and original appearance-results locations are not provided. - Referenced methods: M04 §§4.6.1–4.6.2 distinction between studies and reports; cohort/outcome links are Chamgap adaptations - Related sources: R01 ### N26 · Are subquestions, time points and hair measures kept separate from independent replication? Verification status: Partly verified Reading scope: Summary read; external materials not read - Current findings: One manufacturer trial in the summary contains instrumental density and other endpoints/time points in the same report. Selected appearance has a direct-evidence gap. - Why unverified: Original summary information is linked for production; clinical verification, condition fulfillment and content review are not complete. Unique trial/participant totals and independent replication were not newly searched, summed or certified. - Reason for missing information: Unique trial/participant totals and independent replication were not newly searched, summed or certified. - Required materials and conditions: The same CT-OW-02, 106 participants, days 90/180 and density/cycle ratio/appearance - Materials to obtain first: Trial-report-person-time-area-endpoint links - Further research: Distinguish the same population/re-reporting from different recruitment/trials in additional reports. - Conditions for verification: Link The same CT-OW-02, 106 participants, days 90/180 and density/cycle ratio/appearance to the actual finished product, population, endpoint, timing, denominator/analysis and reading scope; distinguish unverified matters. - Why this condition is needed: Production condition to record the actual scope of The same CT-OW-02, 106 participants, days 90/180 and density/cycle ratio/appearance. - Application exceptions: Do not add days 90/180, hair cycle/areas, parent/sibling sheets or report/material slots as independent trials/participants. - Remaining uncertainty: Within the production scope of the preserved summary. Unique trial/participant totals and independent replication were not newly searched, summed or certified. - Referenced methods: Study/report distinction in M04 §4.6.1–4.6.2; Cohort/outcome linkage is Chamgap application; M04 §4.6.1–4.6.2 and M15 §15.3.1; Chamgap application - Related sources: R01 ### N27 · What were actual manufacturer roles and author relationships? Verification status: Partly verified Reading scope: Summary read; external materials not read - Current findings: The original rationale records Olistic Research Labs S.L. fully paying research/publication fees, sponsorship/responsibility, product/placebo supply and Manuel Sáez Moya company affiliation. - Why unverified: Original summary information is linked for production; clinical verification, condition fulfillment and content review are not complete. Original disclosures of analysis/writing/publication decisions, data access, other authors/relationships and current contracts are unread. - Reason for missing information: Original disclosures of analysis/writing/publication decisions, data access, other authors/relationships and current contracts are unread. - Required materials and conditions: Olistic Research Labs full research/publication funding, sponsor/responsibility, product/placebo and employee author - Materials to obtain first: Original support, product/placebo, author disclosures and analysis/publication roles - Further research: If disclosures are provided, distinguish product supply, funding, sponsor, employee author and analysis/publication. - Conditions for verification: Link Olistic Research Labs full research/publication funding, sponsor/responsibility, product/placebo and employee author to the actual finished product, population, endpoint, timing, denominator/analysis and reading scope; distinguish unverified matters. - Why this condition is needed: Production condition to record the actual scope of Olistic Research Labs full research/publication funding, sponsor/responsibility, product/placebo and employee author. - Application exceptions: Do not hide manufacturer roles or turn one manufacturer trial into current independence certification or a data-manipulation finding. - Remaining uncertainty: Within the production scope of the preserved summary. Original disclosures of analysis/writing/publication decisions, data access, other authors/relationships and current contracts are unread. - Referenced methods: Chamgap's own conditions for independence and attribution. The official methodological sections used in this example do not validate every detail of these items. - Related sources: R01 ### N28 · Can this extend to other products, formulations, ingredients, populations or durability? Verification status: Partly verified Reading scope: Summary read; external materials not read - Current findings: The summary says results cannot extend to Viviscal, Nutrafol or the supplement class and do not establish visible fullness, durability or other-formulation effects. - Why unverified: Original summary information is linked for production; clinical verification, condition fulfillment and content review are not complete. Other products/ingredients, populations, doses/durations and direct appearance/long-term/post-discontinuation outcomes are unverified within this reading scope. - Reason for missing information: Other products/ingredients, populations, doses/durations and direct appearance/long-term/post-discontinuation outcomes are unverified within this reading scope. - Required materials and conditions: Olistic Women finished product, selected population and other products/long-term outcomes - Materials to obtain first: Direct comparisons and appearance results for actual other formulations/populations/durations - Further research: Link actual finished product, population, exposure and endpoints separately in new material. - Conditions for verification: Link Olistic Women finished product, selected population and other products/long-term outcomes to the actual finished product, population, endpoint, timing, denominator/analysis and reading scope; distinguish unverified matters. - Why this condition is needed: Production condition to record the actual scope of Olistic Women finished product, selected population and other products/long-term outcomes. - Application exceptions: Do not write other-brand/ingredient or general hair-loss benefit/safety, consumption or treatment guidance. - Remaining uncertainty: Within the production scope of the preserved summary. Other products/ingredients, populations, doses/durations and direct appearance/long-term/post-discontinuation outcomes are unverified within this reading scope. - Referenced methods: M03 §§3.2.1–3.2.4; dose, durability and effect-modification details are Chamgap-designed; M03 §§3.2.2–3.2.3; reverse-direction labels and assessment adaptation are Chamgap-designed - Related sources: R01 ### N29 · How are original dates, corrections, Korean/English texts, axes and history preserved? Verification status: Partly verified Reading scope: Summary read; external materials not read - Current findings: The cut-off is 2026-08-26, corrections are an empty array and deliberation an empty string. Complete preservation retains Korean/English text, synthesis/assessment decisions, axes, false flags and precision null. - Why unverified: Original summary information is linked for production; clinical verification, condition fulfillment and content review are not complete. Classification and primary_failed_secondary_positive keys are absent. Empty corrections are not a current external correction/retraction check. - Reason for missing information: Classification and primary_failed_secondary_positive keys are absent. Empty corrections are not a current external correction/retraction check. - Required materials and conditions: 2026-08-26, empty corrections/deliberation and original assessment - Materials to obtain first: Complete previous summary and actual change/correction events - Further research: Distinguish complete pre-change text, events, versions and separate application when changes occur. - Conditions for verification: Link 2026-08-26, empty corrections/deliberation and original assessment to the actual finished product, population, endpoint, timing, denominator/analysis and reading scope; distinguish unverified matters. - Why this condition is needed: Production condition to record the actual scope of 2026-08-26, empty corrections/deliberation and original assessment. - Application exceptions: Do not fill absent/empty values or historical cross-checks with new scores/axes or completed review. - Remaining uncertainty: Within the production scope of the preserved summary. Classification and primary_failed_secondary_positive keys are absent. Empty corrections are not a current external correction/retraction check. - Referenced methods: M04 §§4.5 and 4.6.3; limits of the current material conversion follow the review scope and Chamgap design - Related sources: R01 ### N30 · What was actually read and what are external-material states? Verification status: Partly verified Reading scope: Summary read; external materials not read - Current findings: The selected original record and complete preserved 2956 summary were read for production. Distinguish one report summary from unread external/required-material slots. - Why unverified: Original summary information is linked for production; clinical verification, condition fulfillment and content review are not complete. External abstracts, full texts, registration, plans, original results/harms and disclosures were not accessed or acquired. - Reason for missing information: External abstracts, full texts, registration, plans, original results/harms and disclosures were not accessed or acquired. - Required materials and conditions: Complete preserved 2956 summary, selected original record and summary/external distinction - Materials to obtain first: User-provided originals and actual acquisition/reading records - Further research: Distinguish material type, publication/access, acquisition and actual reading scope/dates in new material. - Conditions for verification: Link Complete preserved 2956 summary, selected original record and summary/external distinction to the actual finished product, population, endpoint, timing, denominator/analysis and reading scope; distinguish unverified matters. - Why this condition is needed: Production condition to record the actual scope of Complete preserved 2956 summary, selected original record and summary/external distinction. - Application exceptions: Do not promote URLs, historical paper/registration wording or copies into full-text reading, successful access or link checks. - Remaining uncertainty: Within the production scope of the preserved summary. External abstracts, full texts, registration, plans, original results/harms and disclosures were not accessed or acquired. - Referenced methods: M04 §4.5–4.6 material collection/selection principles; acquisition/reading separation and hyperlink specifications are internally designed; M04 §4.5, §4.6.3; limits of this material conversion follow the review scope and internal design - Related sources: R01 ### N31 · What is linked when new material or corrections become available? Verification status: Partly verified Reading scope: Summary read; external materials not read - Current findings: The original appearance question and parent instrumental context are rendered in the same seven-column format. Conditions were saved/frozen first with separate application timing. - Why unverified: Original summary information is linked for production; clinical verification, condition fulfillment and content review are not complete. No new clinical search, calculation, evidence/effect, reassessment, independence certification or model/self content review was performed. - Reason for missing information: No new clinical search, calculation, evidence/effect, reassessment, independence certification or model/self content review was performed. - Required materials and conditions: Condition version, originals, observations, reading and change event - Materials to obtain first: User-provided direct appearance/patient assessments, denominators, plans, harms/corrections - Further research: Separate actual additions/changes into complete prior versions, events, condition versions/freezing, separate application and current handoff. - Conditions for verification: Link Condition version, originals, observations, reading and change event to the actual finished product, population, endpoint, timing, denominator/analysis and reading scope; distinguish unverified matters. - Why this condition is needed: Production condition to record the actual scope of Condition version, originals, observations, reading and change event. - Application exceptions: Original candidate pending/eligibility states are historical; do not revive active model/content/boundary-review waits. - Remaining uncertainty: Within the production scope of the preserved summary. No new clinical search, calculation, evidence/effect, reassessment, independence certification or model/self content review was performed. - Referenced methods: M04 §§4.5 and 4.6.3; limits of the current material conversion follow the review scope and Chamgap design - Related sources: R01 ### H01 · Were minor adverse events actually collected? Verification status: Partly verified Reading scope: Summary read; external materials not read - Current findings: The summary preserves the authors' explicit statement that minor adverse events were not collected at all and that general tolerability therefore cannot be assessed. - Why unverified: Original summary information is linked for production; clinical verification, condition fulfillment and content review are not complete. Actual minor-event types/frequencies, full collection definitions and relatedness are unverified. The original external wording was not read here. - Reason for missing information: Actual minor-event types/frequencies, full collection definitions and relatedness are unverified. The original external wording was not read here. - Required materials and conditions: Original minor-AE noncollection, definitions/collection and relatedness - Materials to obtain first: Original harm-collection plans, definitions, full results and disclosed wording - Further research: Distinguish minor/serious events by actual collection scope and relatedness in subsequent material. - Conditions for verification: Link Original minor-AE noncollection, definitions/collection and relatedness to the actual finished product, population, endpoint, timing, denominator/analysis and reading scope; distinguish unverified matters. - Why this condition is needed: Production condition to record the actual scope of Original minor-AE noncollection, definitions/collection and relatedness. - Application exceptions: Do not change minor-event noncollection into no events, good tolerability or access failure. - Remaining uncertainty: Within the production scope of the preserved summary. Actual minor-event types/frequencies, full collection definitions and relatedness are unverified. The original external wording was not read here. - Referenced methods: M19 §§19.1.2–19.2.4; detailed distinctions are Chamgap-designed; M19 §§19.1.2–19.2.4; Chamgap adaptation - Related sources: R01 ### H02 · What were actual safety-observation periods and exposure? Verification status: Partly verified Reading scope: Summary read; external materials not read - Current findings: Original product exposure was six months; minor-event noncollection prevents general tolerability assessment. - Why unverified: Original summary information is linked for production; clinical verification, condition fulfillment and content review are not complete. Serious/other harm-collection periods, collection by visit, stopping/follow-up courses and actual exposure are unverified. - Reason for missing information: Serious/other harm-collection periods, collection by visit, stopping/follow-up courses and actual exposure are unverified. - Required materials and conditions: Six-month trial exposure, harm-collection periods and post-discontinuation follow-up - Materials to obtain first: Periods/exposure, collection schedules and stopping/follow-up harm material - Further research: Report the original trial period and actual collection/follow-up periods separately. - Conditions for verification: Link Six-month trial exposure, harm-collection periods and post-discontinuation follow-up to the actual finished product, population, endpoint, timing, denominator/analysis and reading scope; distinguish unverified matters. - Why this condition is needed: Production condition to record the actual scope of Six-month trial exposure, harm-collection periods and post-discontinuation follow-up. - Application exceptions: Do not turn six-month follow-up alone into comprehensive safety collection or long-term safety assurance. - Remaining uncertainty: Within the production scope of the preserved summary. Serious/other harm-collection periods, collection by visit, stopping/follow-up courses and actual exposure are unverified. - Referenced methods: M19 §19.2 design-specific harm questions; timing details are Chamgap-designed - Related sources: R01 ### H03 · Are group-specific product/placebo harm comparisons available? Verification status: Unverified Reading scope: Summary read; external materials not read - Current findings: The summary records minor-event noncollection and safety gaps without providing quantitative group-specific harms. - Why unverified: Direct definitions, values and material needed within the preserved-summary/unread-external scope are unverified. Actual product/placebo events, severity/relatedness, intervals and comparable collection are unverified. - Reason for missing information: Actual product/placebo events, severity/relatedness, intervals and comparable collection are unverified. - Required materials and conditions: Related/all, serious/minor, group-specific events and comparison - Materials to obtain first: Group-specific all/serious harms, relatedness and collection/denominator tables - Further research: Link group definitions, collection, periods and effects/intervals separately in direct harm material. - Conditions for verification: Link Related/all, serious/minor, group-specific events and comparison to the actual finished product, population, endpoint, timing, denominator/analysis and reading scope; distinguish unverified matters. - Why this condition is needed: Production condition to record the actual scope of Related/all, serious/minor, group-specific events and comparison. - Application exceptions: Do not confirm zero serious events or safety equivalence from absent group-specific quantities. - Remaining uncertainty: Within the production scope of the preserved summary. Actual product/placebo events, severity/relatedness, intervals and comparable collection are unverified. - Referenced methods: M19 §§19.2.2–19.2.4 and M03 §3.2.3; Chamgap adaptation - Related sources: R01 ### H04 · How do safety denominators differ from allocation/analysis denominators? Verification status: Partly verified Reading scope: Summary read; external materials not read - Current findings: The 106 participants, 53/53, in the summary are randomized counts. Minor events were not collected. - Why unverified: Original summary information is linked for production; clinical verification, condition fulfillment and content review are not complete. Actual safety exposure/completion, collection/analysis n, group exclusion/stopping and serious-event denominators are unverified. - Reason for missing information: Actual safety exposure/completion, collection/analysis n, group exclusion/stopping and serious-event denominators are unverified. - Required materials and conditions: 53/53 allocation, actual exposure/safety collection and endpoint-specific n - Materials to obtain first: Exposure, stopping, safety populations/denominators and original flow - Further research: Distinguish allocation, exposure, collection and completion/analysis denominators in harm material. - Conditions for verification: Link 53/53 allocation, actual exposure/safety collection and endpoint-specific n to the actual finished product, population, endpoint, timing, denominator/analysis and reading scope; distinguish unverified matters. - Why this condition is needed: Production condition to record the actual scope of 53/53 allocation, actual exposure/safety collection and endpoint-specific n. - Application exceptions: Do not copy 53/53 allocation as collection denominators for all harms or calculate incidence. - Remaining uncertainty: Within the production scope of the preserved summary. Actual safety exposure/completion, collection/analysis n, group exclusion/stopping and serious-event denominators are unverified. - Referenced methods: M19 §§19.1.2–19.2.4; Chamgap adaptation; M08 Table 8.2.a, M15 §15.3 and M19 §§19.1.2–19.2.4; design-specific adaptation is Chamgap-designed - Related sources: R01 ### H05 · What are multi-ingredient, baseline, concurrent-exposure and relatedness records? Verification status: Partly verified Reading scope: Summary read; external materials not read - Current findings: Original exposure concerned a particular drinkable multi-ingredient finished product. Minor harms were outside the original collection scope. - Why unverified: Original summary information is linked for production; clinical verification, condition fulfillment and content review are not complete. Ingredient quantities, concurrent supplements/medication, baseline disease, actual cases, alternative factors and relatedness judgments are unverified. - Reason for missing information: Ingredient quantities, concurrent supplements/medication, baseline disease, actual cases, alternative factors and relatedness judgments are unverified. - Required materials and conditions: Finished product, individual ingredients, baseline/concurrent management and harm relatedness - Materials to obtain first: Product composition, concurrent exposure, actual cases and relatedness review - Further research: Distinguish finished product, individual ingredients and baseline/concurrent factors in direct harm material. - Conditions for verification: Link Finished product, individual ingredients, baseline/concurrent management and harm relatedness to the actual finished product, population, endpoint, timing, denominator/analysis and reading scope; distinguish unverified matters. - Why this condition is needed: Production condition to record the actual scope of Finished product, individual ingredients, baseline/concurrent management and harm relatedness. - Application exceptions: Do not invent unrecorded allergy/interaction cases as observed events or newly attribute product harm to an ingredient. - Remaining uncertainty: Within the production scope of the preserved summary. Ingredient quantities, concurrent supplements/medication, baseline disease, actual cases, alternative factors and relatedness judgments are unverified. - Referenced methods: M19 §§19.2.2–19.2.4 design considerations; detailed confounding records are Chamgap-designed - Related sources: R01 ### H06 · Are noncollection, nonreporting, unread material and zero events distinguished? Verification status: Partly verified Reading scope: Summary read; external materials not read - Current findings: The original record describes minor-event noncollection; external full texts/tables are currently unread. These remain distinct states. - Why unverified: Original summary information is linked for production; clinical verification, condition fulfillment and content review are not complete. Actual noncollection/nonreporting/missingness/zero distinctions for other harms and serious-event originals are unverified. - Reason for missing information: Actual noncollection/nonreporting/missingness/zero distinctions for other harms and serious-event originals are unverified. - Required materials and conditions: Original minor-AE noncollection, currently unread external material and other-harm states - Materials to obtain first: Full safety collection/results, omission reasons and reading records - Further research: Distinguish collection scope, nonreporting/missingness and actual zero only within provided material. - Conditions for verification: Link Original minor-AE noncollection, currently unread external material and other-harm states to the actual finished product, population, endpoint, timing, denominator/analysis and reading scope; distinguish unverified matters. - Why this condition is needed: Production condition to record the actual scope of Original minor-AE noncollection, currently unread external material and other-harm states. - Application exceptions: Do not change minor-AE noncollection or current nonreading into all events zero, absent papers or access failure. - Remaining uncertainty: Within the production scope of the preserved summary. Actual noncollection/nonreporting/missingness/zero distinctions for other harms and serious-event originals are unverified. - Referenced methods: M19 §§19.1.2–19.2.4 and M04 §4.6.3; Chamgap adaptation - Related sources: R01 ### H07 · Are manufacturer reports, time points and questions kept separate from duplicate totals? Verification status: Partly verified Reading scope: Summary read; external materials not read - Current findings: Days 90/180, density/cycle ratio and appearance questions in one report remain one trial context. Direct appearance effects/harms are separately unverified. - Why unverified: Original summary information is linked for production; clinical verification, condition fulfillment and content review are not complete. New independent harm reports, duplicated events/people and other recruitment populations were not verified here. - Reason for missing information: New independent harm reports, duplicated events/people and other recruitment populations were not verified here. - Required materials and conditions: The same CT-OW-02, 106 participants and instrumental/appearance/harm family - Materials to obtain first: Trial-person-time-endpoint-event-report links - Further research: Distinguish re-reporting of the same events from new trials/events in additional harm material. - Conditions for verification: Link The same CT-OW-02, 106 participants and instrumental/appearance/harm family to the actual finished product, population, endpoint, timing, denominator/analysis and reading scope; distinguish unverified matters. - Why this condition is needed: Production condition to record the actual scope of The same CT-OW-02, 106 participants and instrumental/appearance/harm family. - Application exceptions: Do not add material slots, two subquestions, time points or areas as independent trials, participants or events. - Remaining uncertainty: Within the production scope of the preserved summary. New independent harm reports, duplicated events/people and other recruitment populations were not verified here. - Referenced methods: M04 §§4.6.1–4.6.2; harm-material adaptation is Chamgap-designed; M04 §§4.6.1–4.6.2 distinction between studies and reports; cohort/outcome links are Chamgap adaptations - Related sources: R01 ### H08 · What long-term safety gaps concern other populations, periods and products? Verification status: Partly verified Reading scope: Summary read; external materials not read - Current findings: Parent safety is Unknown and the trial concerns a particular finished product and selected population. - Why unverified: Original summary information is linked for production; clinical verification, condition fulfillment and content review are not complete. Longer/different exposures, other products/ingredients, postmenopausal/other populations and disease/medication-specific direct harms are unverified in this scope. - Reason for missing information: Longer/different exposures, other products/ingredients, postmenopausal/other populations and disease/medication-specific direct harms are unverified in this scope. - Required materials and conditions: Premenopausal telogen effluvium, finished product, six months and other conditions - Materials to obtain first: Direct harms by population/product/period and long-term collection - Further research: State actual population, finished product/exposure, period and collection level in new harm material. - Conditions for verification: Link Premenopausal telogen effluvium, finished product, six months and other conditions to the actual finished product, population, endpoint, timing, denominator/analysis and reading scope; distinguish unverified matters. - Why this condition is needed: Production condition to record the actual scope of Premenopausal telogen effluvium, finished product, six months and other conditions. - Application exceptions: Do not turn positive instrumental findings into long-term supplement safety or consumption/treatment guidance. - Remaining uncertainty: Within the production scope of the preserved summary. Longer/different exposures, other products/ingredients, postmenopausal/other populations and disease/medication-specific direct harms are unverified in this scope. - Referenced methods: M19 §§19.1.2–19.2.4; Chamgap adaptation - Related sources: R01 ### H09 · Are instrumental signals, appearance gaps and Unknown safety retained together? Verification status: Partly verified Reading scope: Summary read; external materials not read - Current findings: Distinguish positive parent instrumental density from selected appearance ? while retaining minor-event noncollection and Unknown safety. - Why unverified: Original summary information is linked for production; clinical verification, condition fulfillment and content review are not complete. No new benefit-harm synthesis, treatment/product selection or independence/causal certification was performed. - Reason for missing information: No new benefit-harm synthesis, treatment/product selection or independence/causal certification was performed. - Required materials and conditions: Original instrumental C, selected appearance ?, minor-AE noncollection and harm gaps - Materials to obtain first: Direct appearance/patient results, harms and original follow-up material - Further research: Link each instrumental, appearance and harm endpoint, original location and change event separately in additional material. - Conditions for verification: Link Original instrumental C, selected appearance ?, minor-AE noncollection and harm gaps to the actual finished product, population, endpoint, timing, denominator/analysis and reading scope; distinguish unverified matters. - Why this condition is needed: Production condition to record the actual scope of Original instrumental C, selected appearance ?, minor-AE noncollection and harm gaps. - Application exceptions: Do not change instrumental positivity into appearance benefit or safety assurance, or appearance gaps into zero effect or treatment recommendations. - Remaining uncertainty: Within the production scope of the preserved summary. No new benefit-harm synthesis, treatment/product selection or independence/causal certification was performed. - Referenced methods: Chamgap interpretive boundary informed by M19 principles; no formal causality tool was run - Related sources: R01 ## Evidence and sources ### R01 Sáez Moya M, et al. Efficacy and Safety of a Drinkable Nutraceutical in Premenopausal Women with Telogen Effluvium. Dermatol Ther (Heidelb). 2025. PMID: 41288927. [PubMed](https://pubmed.ncbi.nlm.nih.gov/41288927/) Materials actually read: Summary read; external materials not read Findings recorded in the summary: +27.31±2.61 versus +18.23±2.98 hairs/cm², P<0.01; 95% CI not reported. Instrumental density results, not direct selected appearance/patient-perception effects. Distinguish original subclaim ? and the note that appearance was not primary. Record level: First original evidence record: instrumental endpoint and parent appearance/harm boundaries Independent replication: One preserved-summary report for the same CT-OW-02/Olistic Women finished product and selected population of women. Do not add days 90/180, density/cycle ratio or parent/subclaim sheets as new independent trials or participants. | Material | Public availability | Access status | Actually read | Notes | |---|---|---|---|---| | Stored summary | Local preserved summary | Local copy acquired | Summary read | Production reading of complete preserved 2956 bibliography, instrumental/appearance boundaries and registration/support/harm context; external paper not read. | | External abstract | Current publication/access unverified | Access not attempted; not obtained | Not read | Only the original citation URL is linked; current abstract contents/access unverified. | | External full text | Current publication/access unverified | Access not attempted; not obtained | Not read | Only the original report-identity source link is connected; current full-text location/publication/access unverified. | | Registration | Current publication/access unverified | Access not attempted; not obtained | Not read | Original registration identifier and retrospective-registration dates retained; no current contents/history lookup. | | Protocol | Current publication/access unverified | Access not attempted; not obtained | Not read | Required-material slot; actual file existence/publication, appearance/instrumental hierarchy and prospective plans unverified. | | Statistical analysis plan | Current publication/access unverified | Access not attempted; not obtained | Not read | Required-material slot for appearance/instrumental denominators, models, multiple comparisons, missingness and selective analysis. | | Results, denominator and harm details | Current publication/access unverified | Access not attempted; not obtained | Not read | Required originals for actual appearance results, denominators, intervals, instrumental contrasts and collected harms. Do not change noncollection/nonreading into zero. | | Support and interests | Current publication/access unverified | Access not attempted; not obtained | Not read | Distinguish original full funding, sponsorship, supply and employee-author context from current external disclosures. | ## Review criteria and methods These are Chamgap's own application conditions, informed by the relevant sections of official methodological guidance. They do not constitute official assessment-tool certification or a new efficacy score. - M03 [Cochrane Handbook 6.5 (2024), chapter updated 2023-08](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03) · §3.1, §3.2.1–3.2.3, MECIR C5/C7/C13 · Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions. · Methodological principles stated in existing pilot materials and condition templates were referenced. The methodological text was not reviewed again in this work. - M04 [Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04) · §4.5, §4.6.1–4.6.3, MECIR C42 · Distinguish studies from reports and link them; do not omit a study solely because results are unreported. · Methodological principles stated in existing pilot materials and condition templates were referenced. The methodological text was not reviewed again in this work. - M08 [Cochrane Handbook 6.5 (2024), chapter updated 2019-10](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08) · §8.1–8.2.3, Table 8.2.a · Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting. · Methodological principles stated in existing pilot materials and condition templates were referenced. The methodological text was not reviewed again in this work. - M15 [Cochrane Handbook 6.5 (2024), chapter updated 2023-08](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15) · §15.2.4, §15.3.1–15.3.3 · Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision. · Methodological principles stated in existing pilot materials and condition templates were referenced. The methodological text was not reviewed again in this work. - M19 [Cochrane Handbook 6.5 (2024), chapter updated 2019-10](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19) · §19.1.2, §19.2.1–19.2.4 · Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates. · Methodological principles stated in existing pilot materials and condition templates were referenced. The methodological text was not reviewed again in this work. ## What the statuses mean - Met: The original content has been reviewed as meeting the conditions. This status is not used in this preparation. - Partly verified: Some information in the stored summary was linked during preparation; clinical verification or review is not complete. - Unverified: Required direct values, definitions or materials have not been established within the current storage and reading scope. This does not mean zero effect, no papers or failed access. - Review incomplete: Review of existing content or actual review incomplete. - Not reported: Used only when original materials were actually read and the outcome was judged unreported. Not used for external materials unread in this work. - Inaccessible: Used only when an actual access attempt has a recorded failure. Not used for access that was not attempted in this work. - Insufficient evidence for the conditions: Indicates insufficient direct materials for the relevant scope or conditions; it is not a new grade. - Not applicable: Used when the reason it does not apply to the original question is stated. - Conflicting data: Retains the scope of conflicting statements in original materials; it is not an arbitrary reassessment. ## Change history 2026-10-12 · Public page/materials 1.0. The public page and data were prepared from the existing 40 items. No new clinical search, verification-status change or scoring was performed.