{
  "schema_version": "chamgap-public-evidence-check-1.0",
  "public_id": "v2955-s1",
  "verdict_number": "2955",
  "title": "Quercetin 500 mg daily × Improved clinical liver outcomes — Evidence Check",
  "view_version": "1.0",
  "view_created_date": "2026-10-12",
  "criteria_version": "1.0",
  "criteria_date": "2026-10-06",
  "review_date": null,
  "legacy_evidence_date": "2026-08-26",
  "review_scope": {
    "materials_read": "Existing review summaries and stored records of methodological application",
    "clinical_papers_directly_read": false,
    "new_clinical_search": false,
    "limitation": "The whole stored parent-verdict summary and selected subclaim were read for production. External papers, abstracts, full texts, registry, protocol, SAP and funding disclosures were not separately read or accessed. Historical review records are not inherited as current clinical verification or a new verdict.",
    "date_meaning": "This is the date the stored materials were checked, not the date of a new search of the clinical literature."
  },
  "claim_context": {
    "population": "The current preserved summary concerns an MRI crossover trial in nonalcoholic fatty liver disease: 41 participants, 36 completed. Do not transfer them to verified populations/event denominators for clinical cirrhosis, hospitalization or death. Clinical disease stage, baseline risk, recruitment/group-specific analysis/observation and censoring/missingness remain unverified without direct material.",
    "intervention": "The direct intervention/comparison for the selected clinical outcome is unverified. Link only MRI exposure/comparison context from the original quercetin 500 mg/placebo crossover; do not present it as a dose or method with verified clinical benefit. Product/duration, actual exposure/adherence/concurrent treatment and subsequent strategies are unverified; no new intake or treatment guidance is created.",
    "dose": "12 weeks and crossover after a 4-week washout are MRI trial conditions, not verified treatment/assessment periods for clinical disease. Direct clinical exposure, dose/duration, long-term follow-up and discontinuation are unverified; no new duration/dose conversions are performed.",
    "comparator": "The original double-blind MRI placebo crossover and reported ITT do not verify direct clinical disease allocation, comparison or analysis. Control, allocation/adjudication, concurrent management/treatment, models/missingness and actual units in clinical trials/endpoints are unverified.",
    "endpoint": "The selected existing ? grade/note records that this trial did not test cirrhosis, hospitalization or death. Definitions/adjudication, events/denominators, timing, between-group effects/CIs/P values, prespecified important differences and power for these clinical endpoints are unverified. MRI 11.5%±6.4→9.6%±5.8, placebo change −0.1%±2.6, P=.013, adjusted P=.028 and weight changes/correlation are other measures, not clinical estimates/effects. Do not turn untested outcomes into zero effects/events, safety certification or confirmed null effects.",
    "duration": "Direct clinical disease follow-up/assessment windows, cumulative/recurrent events/hospitalization, censoring/death and follow-up material are unverified. Distinguish original 12-week MRI/crossover from long-term testing of cirrhosis, hospitalization or death. Do not invent follow-up reports/numbers.",
    "excluded_extensions": [
      "New effect/change/response-rate/CI calculations or arbitrary %/%p corrections from MRI baseline/final values, placebo change, original approximate −1.9 percentage points/P values/± quantities and sample sizes",
      "Summing two crossover periods/the same participants as new independent trials/participants, or deriving hypothetical total duration/exposure from 12 weeks/4 weeks",
      "Filling an ITT account with unverified observed denominators, imputation models or an all-completer population",
      "Turning weight correlation and MRI benefit into confirmation of direct hepatic causation/separated mediation, or calculating new direct effects",
      "Reusing MRI/liver-enzyme/other secondary outcomes as improved cirrhosis/hospitalization/death, or exactly zero clinical effects/equivalence",
      "Inheriting historical CI/funding checking in abstracts/public tables/full text as current whole external-document reading/review",
      "Turning undisclosed manufacturer support, institutional affiliations/no-COI declarations and original I2 into absence of each support item/current independence verification",
      "Turning original safety non-reporting/nonsignificance and rare-harm limitations into zero harms or treatment-safety certification",
      "Creating currently absent clinical original reports/registration/follow-up materials or invented citations/values",
      "Inheriting parent scores/axes and historical cross-checking as subclaim scores/current review/external reading",
      "New calculations, hypothetical values, effects/CIs, grades, independence certification or product-intake/diet/activity/testing/treatment implementation guidance"
    ]
  },
  "requirements": [
    {
      "item_id": "N01",
      "question_type": "Evidence condition",
      "question": "Selected clinical liver outcome and original values",
      "needed": "Existing question, grade and note; parent context and absent fields",
      "role": "Required",
      "role_reason": "Distinguish Existing question, grade and note; parent context and absent fields to connect materials needed for the selected question with the current materials in this production item.",
      "application_exception": "Preserve the existing ? grade/untested-outcome note for the selected clinical liver outcome and the current MRI report context. Retain gaps in direct cirrhosis/hospitalization/death material, definitions, effects, denominators and duration. Do not substitute MRI/weight/liver-enzyme measures, values, support or safety for direct clinical effects or create new intake/treatment guidance.",
      "criterion": "Existing question, grade and note; parent context and absent fields requires corresponding original material/analysis scope and a distinction of unverified matters. Original wording is linked here; content review remains incomplete.",
      "basis": "M03 §3.1, §3.2.1–3.2.4 question-clarification principles; detailed separation rules are custom design; M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptation is custom design; M04 §4.5, §4.6.3; limits on current material conversion reflect the review scope and custom design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Connect the original question to additional materials in proposed update research; no new investigation, calculation or trial is performed now.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "Preserve the existing ? grade for improved clinical liver outcomes and the note that cirrhosis, hospitalization and death were not tested. Parent C54 and the positive MRI result belong to the separate original assessment context.",
      "condition_status": "Partly verified",
      "status_reason": "Only corresponding information in the preserved summary is recorded; detailed original materials are unread and content review remains incomplete. The subclaim has no score, status or assessment axes; do not fill them with parent values. Do not create clinical benefit, a null effect, a grade or independent certification. Content review remains incomplete.",
      "missingness": "The subclaim has no score, status or assessment axes; do not fill them with parent values. Do not create clinical benefit, a null effect, a grade or independent certification.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Selected question, parent assessment and direct clinical material"
    },
    {
      "item_id": "N02",
      "question_type": "Evidence condition",
      "question": "Clinical outcomes: definitions and measurement",
      "needed": "Definitions and adjudication of original outcomes such as cirrhosis, hospitalization and death",
      "role": "Required",
      "role_reason": "Distinguish Definitions and adjudication of original outcomes such as cirrhosis, hospitalization and death to connect materials needed for the selected question with the current materials in this production item.",
      "application_exception": "Preserve the existing ? grade/untested-outcome note for the selected clinical liver outcome and the current MRI report context. Retain gaps in direct cirrhosis/hospitalization/death material, definitions, effects, denominators and duration. Do not substitute MRI/weight/liver-enzyme measures, values, support or safety for direct clinical effects or create new intake/treatment guidance.",
      "criterion": "Definitions and adjudication of original outcomes such as cirrhosis, hospitalization and death requires corresponding original material/analysis scope and a distinction of unverified matters. Original wording is linked here; content review remains incomplete.",
      "basis": "M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptation is custom design; M08 Table 8.2.a, M03 §3.2.4; custom application; M03 §3.2.4; custom extension boundary; M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; design-specific adaptation is custom design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed research distinguishing imaging/laboratory measures from clinical outcomes; no new investigation, calculation or trial is performed now.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "The original note states that this trial did not test cirrhosis, hospitalization or death. Distinguish MRI liver fat and liver enzymes from actual disease outcomes.",
      "condition_status": "Unverified",
      "status_reason": "Information currently needed is unverified in the preserved summary. Definitions, adjudication/verification, events/denominators, timing and data linkage for direct clinical endpoints are unverified. Untested outcomes must not become zero events or zero effect. Content review remains incomplete.",
      "missingness": "Definitions, adjudication/verification, events/denominators, timing and data linkage for direct clinical endpoints are unverified. Untested outcomes must not become zero events or zero effect.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Clinical endpoint definitions/adjudication and direct event/observation data"
    },
    {
      "item_id": "N03",
      "question_type": "Evidence condition",
      "question": "Participants, disease and risk scope",
      "needed": "Original MRI participants and the population analyzed for clinical outcomes",
      "role": "Required",
      "role_reason": "Distinguish Original MRI participants and the population analyzed for clinical outcomes to connect materials needed for the selected question with the current materials in this production item.",
      "application_exception": "Preserve the existing ? grade/untested-outcome note for the selected clinical liver outcome and the current MRI report context. Retain gaps in direct cirrhosis/hospitalization/death material, definitions, effects, denominators and duration. Do not substitute MRI/weight/liver-enzyme measures, values, support or safety for direct clinical effects or create new intake/treatment guidance.",
      "criterion": "Original MRI participants and the population analyzed for clinical outcomes requires corresponding original material/analysis scope and a distinction of unverified matters. Original wording is linked here; content review remains incomplete.",
      "basis": "M03 §3.2.1; detailed population conditions are custom design; M03 §3.2.1–3.2.4; dose/duration/effect-modification details are custom design; M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; design-specific adaptation is custom design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed research on disease/population and the applicability of clinical effects; no new investigation, calculation or trial is performed now.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "The current direct bibliography concerns an MRI crossover trial in 41 people with nonalcoholic fatty liver disease. Do not transfer them into a verified direct population for the selected clinical outcome.",
      "condition_status": "Partly verified",
      "status_reason": "Only corresponding information in the preserved summary is recorded; detailed original materials are unread and content review remains incomplete. Clinical disease stage, baseline risk, eligibility, populations by group and clinical-event denominators/missingness are unverified. Do not transfer an effect to every liver disease or population. Content review remains incomplete.",
      "missingness": "Clinical disease stage, baseline risk, eligibility, populations by group and clinical-event denominators/missingness are unverified. Do not transfer an effect to every liver disease or population.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Disease-specific recruitment/baseline data and direct analysis/observation populations"
    },
    {
      "item_id": "N04",
      "question_type": "Evidence condition",
      "question": "Quercetin and direct clinical intervention",
      "needed": "Formulation, dose, strategy and actual clinical comparison",
      "role": "Required",
      "role_reason": "Distinguish Formulation, dose, strategy and actual clinical comparison to connect materials needed for the selected question with the current materials in this production item.",
      "application_exception": "Preserve the existing ? grade/untested-outcome note for the selected clinical liver outcome and the current MRI report context. Retain gaps in direct cirrhosis/hospitalization/death material, definitions, effects, denominators and duration. Do not substitute MRI/weight/liver-enzyme measures, values, support or safety for direct clinical effects or create new intake/treatment guidance.",
      "criterion": "Formulation, dose, strategy and actual clinical comparison requires corresponding original material/analysis scope and a distinction of unverified matters. Original wording is linked here; content review remains incomplete.",
      "basis": "M03 §3.2.2–3.2.3; reverse-direction labels and checking adaptations are internally designed; M03 §3.2.3, M08 §8.2.2–8.2.3; internal application; M03 §3.2.1–3.2.4; dose, duration and effect-modification details are internally designed",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed research on formulation/strategy and attribution to the clinical question; no new investigation, calculation or trial is performed now.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "500 mg/day, 12 weeks and placebo crossover are exposure/comparison conditions of the original MRI trial. Do not describe them as a dose or method with verified clinical liver benefit.",
      "condition_status": "Unverified",
      "status_reason": "Information currently needed is unverified in the preserved summary. Product/composition, dose/duration, intervention/control, actual exposure, adherence and subsequent treatment in direct clinical trials are unverified. Do not create new dosing or treatment guidance. Content review remains incomplete.",
      "missingness": "Product/composition, dose/duration, intervention/control, actual exposure, adherence and subsequent treatment in direct clinical trials are unverified. Do not create new dosing or treatment guidance.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Product/intervention/control and actual exposure data for each clinical trial"
    },
    {
      "item_id": "N05",
      "question_type": "Evidence condition",
      "question": "Direct bibliography, registration and report relationships",
      "needed": "Direct original reports, registration and correspondence for the selected clinical question",
      "role": "Required",
      "role_reason": "Distinguish Direct original reports, registration and correspondence for the selected clinical question to connect materials needed for the selected question with the current materials in this production item.",
      "application_exception": "Preserve the existing ? grade/untested-outcome note for the selected clinical liver outcome and the current MRI report context. Retain gaps in direct cirrhosis/hospitalization/death material, definitions, effects, denominators and duration. Do not substitute MRI/weight/liver-enzyme measures, values, support or safety for direct clinical effects or create new intake/treatment guidance.",
      "criterion": "Direct original reports, registration and correspondence for the selected clinical question requires corresponding original material/analysis scope and a distinction of unverified matters. Original wording is linked here; content review remains incomplete.",
      "basis": "M04 §4.5–4.6 material-collection/selection principles; separation of access/reading and hyperlink conventions are custom design; M04 §4.6.1–4.6.2 distinction between studies and reports; cohort/outcome linkage is a custom application; M03 §3.1, §3.2.1–3.2.4 question-clarification principles; detailed separation rules are custom design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed research linking the original text/assessment with direct reports; no new investigation, calculation or trial is performed now.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "The existing evidence and citation lists contain only the Li 2024 MRI trial. This preserved review summary links no direct report of clinical cirrhosis, hospitalization or death.",
      "condition_status": "Partly verified",
      "status_reason": "Only corresponding information in the preserved summary is recorded; detailed original materials are unread and content review remains incomplete. Direct clinical originals, trial/registration, plans/follow-up material, identity and scope are unverified or unread. Do not invent reports/URLs or new external reading. Content review remains incomplete.",
      "missingness": "Direct clinical originals, trial/registration, plans/follow-up material, identity and scope are unverified or unread. Do not invent reports/URLs or new external reading.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Direct bibliography, registration and original reports for clinical endpoints"
    },
    {
      "item_id": "N06",
      "question_type": "Evidence condition",
      "question": "Original MRI values and clinical effects",
      "needed": "Surrogate comparisons/timing and their relationship to clinical outcomes",
      "role": "Required",
      "role_reason": "Distinguish Surrogate comparisons/timing and their relationship to clinical outcomes to connect materials needed for the selected question with the current materials in this production item.",
      "application_exception": "Preserve the existing ? grade/untested-outcome note for the selected clinical liver outcome and the current MRI report context. Retain gaps in direct cirrhosis/hospitalization/death material, definitions, effects, denominators and duration. Do not substitute MRI/weight/liver-enzyme measures, values, support or safety for direct clinical effects or create new intake/treatment guidance.",
      "criterion": "Surrogate comparisons/timing and their relationship to clinical outcomes requires corresponding original material/analysis scope and a distinction of unverified matters. Original wording is linked here; content review remains incomplete.",
      "basis": "M03 §3.2.4; custom extension boundary; M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptation is custom design; M04 §4.6.3, M15 §15.3.1–15.3.3; status separation is custom design; M15 §15.3.1–15.3.3; custom application",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed research distinguishing surrogate results from actual disease outcomes; no new investigation, calculation or trial is performed now.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "MRI 11.5%±6.4→9.6%±5.8, placebo change −0.1%±2.6, P=.013 and adjusted P=.028 are MRI results. They are not estimates for cirrhosis, hospitalization or death.",
      "condition_status": "Partly verified",
      "status_reason": "Only corresponding information in the preserved summary is recorded; detailed original materials are unread and content review remains incomplete. Imaging/disease correspondence by person and timepoint and direct clinical material are unverified. Do not calculate clinical events, effects or CIs from MRI changes. Content review remains incomplete.",
      "missingness": "Imaging/disease correspondence by person and timepoint and direct clinical material are unverified. Do not calculate clinical events, effects or CIs from MRI changes.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Person-level timing and outcome correspondence between MRI and clinical events"
    },
    {
      "item_id": "N07",
      "question_type": "Evidence condition",
      "question": "Between-group clinical effects, CIs and thresholds",
      "needed": "Direct clinical effect/precision and prespecified important difference",
      "role": "Required",
      "role_reason": "Distinguish Direct clinical effect/precision and prespecified important difference to connect materials needed for the selected question with the current materials in this production item.",
      "application_exception": "Preserve the existing ? grade/untested-outcome note for the selected clinical liver outcome and the current MRI report context. Retain gaps in direct cirrhosis/hospitalization/death material, definitions, effects, denominators and duration. Do not substitute MRI/weight/liver-enzyme measures, values, support or safety for direct clinical effects or create new intake/treatment guidance.",
      "criterion": "Direct clinical effect/precision and prespecified important difference requires corresponding original material/analysis scope and a distinction of unverified matters. Original wording is linked here; content review remains incomplete.",
      "basis": "M15 §15.3.1–15.3.3; custom application; M08 Table 8.2.a, M04 §4.6.3; custom application; M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; design-specific adaptation is custom design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed research distinguishing clinical uncertainty from clinical meaning; no new investigation, calculation or trial is performed now.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "The original positive MRI result, absent CI in the abstract/public table and undeclared minimum MRI threshold are not verified values or an analysis specification for a clinical effect.",
      "condition_status": "Unverified",
      "status_reason": "Information currently needed is unverified in the preserved summary. Clinical-event values by group, effects/CIs/P values, models, prespecified important differences and power are unverified. Do not create a treatment effect, null effect, CI or threshold. Content review remains incomplete.",
      "missingness": "Clinical-event values by group, effects/CIs/P values, models, prespecified important differences and power are unverified. Do not create a treatment effect, null effect, CI or threshold.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original clinical analyses, events/estimates/CIs and important-difference/power material"
    },
    {
      "item_id": "N08",
      "question_type": "Evidence condition",
      "question": "Clinical timing and long-term follow-up",
      "needed": "Specifications for event occurrence, exposure, follow-up and censoring",
      "role": "Required",
      "role_reason": "Distinguish Specifications for event occurrence, exposure, follow-up and censoring to connect materials needed for the selected question with the current materials in this production item.",
      "application_exception": "Preserve the existing ? grade/untested-outcome note for the selected clinical liver outcome and the current MRI report context. Retain gaps in direct cirrhosis/hospitalization/death material, definitions, effects, denominators and duration. Do not substitute MRI/weight/liver-enzyme measures, values, support or safety for direct clinical effects or create new intake/treatment guidance.",
      "criterion": "Specifications for event occurrence, exposure, follow-up and censoring requires corresponding original material/analysis scope and a distinction of unverified matters. Original wording is linked here; content review remains incomplete.",
      "basis": "M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptation is custom design; M03 §3.2.1–3.2.4; dose/duration/effect-modification details are custom design; M08 §8.2.2, M15 §15.3.1; custom application; M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; design-specific adaptation is custom design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed follow-up research distinguishing duration from disease outcomes; no new investigation, calculation or trial is performed now.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "The 12-week MRI period and crossover after a four-week washout are not a verified assessment period for clinical cirrhosis, hospitalization or death.",
      "condition_status": "Unverified",
      "status_reason": "Information currently needed is unverified in the preserved summary. Assessment windows, occurrence/recurrence, long-term follow-up/censoring, discontinuation/death and competing events for direct clinical outcomes are unverified. Do not newly calculate total duration or event totals. Content review remains incomplete.",
      "missingness": "Assessment windows, occurrence/recurrence, long-term follow-up/censoring, discontinuation/death and competing events for direct clinical outcomes are unverified. Do not newly calculate total duration or event totals.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Long-term clinical follow-up, timing/censoring and event/exposure data"
    },
    {
      "item_id": "N09",
      "question_type": "Evidence condition",
      "question": "Clinical participants/events, denominators and missingness",
      "needed": "Randomized, observed and analyzed units and clinical-event units",
      "role": "Required",
      "role_reason": "Distinguish Randomized, observed and analyzed units and clinical-event units to connect materials needed for the selected question with the current materials in this production item.",
      "application_exception": "Preserve the existing ? grade/untested-outcome note for the selected clinical liver outcome and the current MRI report context. Retain gaps in direct cirrhosis/hospitalization/death material, definitions, effects, denominators and duration. Do not substitute MRI/weight/liver-enzyme measures, values, support or safety for direct clinical effects or create new intake/treatment guidance.",
      "criterion": "Randomized, observed and analyzed units and clinical-event units requires corresponding original material/analysis scope and a distinction of unverified matters. Original wording is linked here; content review remains incomplete.",
      "basis": "M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; design-specific adaptation is custom design; M08 §8.2.2, M15 §15.3.1; custom application; M04 §4.6.1–4.6.2 distinction between studies and reports; cohort/outcome linkage is a custom application",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed research on population/event units and missing-data assumptions; no new investigation, calculation or trial is performed now.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "41 randomized and 36 completed are data from the MRI crossover trial.",
      "condition_status": "Unverified",
      "status_reason": "Information currently needed is unverified in the preserved summary. Groups/denominators, people/recurrent events, exclusion, missingness, withdrawal/censoring, analysis and missing-data models for each direct clinical endpoint are unverified. Do not automatically reuse MRI denominators. Content review remains incomplete.",
      "missingness": "Groups/denominators, people/recurrent events, exclusion, missingness, withdrawal/censoring, analysis and missing-data models for each direct clinical endpoint are unverified. Do not automatically reuse MRI denominators.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Population flow, events/denominators and missingness/model material for each clinical endpoint"
    },
    {
      "item_id": "N10",
      "question_type": "Evidence condition",
      "question": "Original allocation/blinding and clinical adjudication",
      "needed": "Allocation, measurement and analysis procedures in direct clinical trials",
      "role": "Required",
      "role_reason": "Distinguish Allocation, measurement and analysis procedures in direct clinical trials to connect materials needed for the selected question with the current materials in this production item.",
      "application_exception": "Preserve the existing ? grade/untested-outcome note for the selected clinical liver outcome and the current MRI report context. Retain gaps in direct cirrhosis/hospitalization/death material, definitions, effects, denominators and duration. Do not substitute MRI/weight/liver-enzyme measures, values, support or safety for direct clinical effects or create new intake/treatment guidance.",
      "criterion": "Allocation, measurement and analysis procedures in direct clinical trials requires corresponding original material/analysis scope and a distinction of unverified matters. Original wording is linked here; content review remains incomplete.",
      "basis": "M08 §8.1–8.2.3; custom application; M08 Table 8.2.a, M03 §3.2.4; custom application; M08 §8.2.2, M15 §15.3.1; custom application; M04 §4.5–4.6 material-collection/selection principles; separation of access/reading and hyperlink conventions are custom design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed research on procedures and clinically observed outcomes; no new investigation, calculation or trial is performed now.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "The original double-blind MRI crossover design description belongs to the parent trial context.",
      "condition_status": "Unverified",
      "status_reason": "Information currently needed is unverified in the preserved summary. Direct allocation units/sequences, generation/concealment, clinical adjudication/analysis blinding, measurement and models for clinical effects are unverified. Do not inherit original B1 or ITT as a new clinical review. Content review remains incomplete.",
      "missingness": "Direct allocation units/sequences, generation/concealment, clinical adjudication/analysis blinding, measurement and models for clinical effects are unverified. Do not inherit original B1 or ITT as a new clinical review.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Direct clinical allocation, adjudication/measurement and analysis records"
    },
    {
      "item_id": "N11",
      "question_type": "Evidence condition",
      "question": "Clinical registration and prespecified plans",
      "needed": "Registration/hierarchy, analysis and changes for the selected clinical endpoint",
      "role": "Required",
      "role_reason": "Distinguish Registration/hierarchy, analysis and changes for the selected clinical endpoint to connect materials needed for the selected question with the current materials in this production item.",
      "application_exception": "Preserve the existing ? grade/untested-outcome note for the selected clinical liver outcome and the current MRI report context. Retain gaps in direct cirrhosis/hospitalization/death material, definitions, effects, denominators and duration. Do not substitute MRI/weight/liver-enzyme measures, values, support or safety for direct clinical effects or create new intake/treatment guidance.",
      "criterion": "Registration/hierarchy, analysis and changes for the selected clinical endpoint requires corresponding original material/analysis scope and a distinction of unverified matters. Original wording is linked here; content review remains incomplete.",
      "basis": "M08 Table 8.2.a, M04 §4.6.3; custom application; M04 §4.5–4.6 material-collection/selection principles; separation of access/reading and hyperlink conventions are custom design; M04 §4.5, §4.6.3; limits on current material conversion reflect the review scope and custom design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed research linking prespecified plans with clinical reports; no new investigation, calculation or trial is performed now.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "ChiCTR2100047904 and the primary MRI endpoint description are the preserved identity and plan of the original MRI trial. Do not promote clinical endpoints to prespecified, verified outcomes.",
      "condition_status": "Unverified",
      "status_reason": "Information currently needed is unverified in the preserved summary. Original clinical plans/registration history, endpoint hierarchy/multiplicity, SAP, follow-up/changes and report correspondence are unread. Content review remains incomplete.",
      "missingness": "Original clinical plans/registration history, endpoint hierarchy/multiplicity, SAP, follow-up/changes and report correspondence are unread.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Direct clinical registration, protocol/SAP and follow-up/change material"
    },
    {
      "item_id": "N12",
      "question_type": "Evidence condition",
      "question": "Weight mediation and direct liver effects",
      "needed": "Weight/exposure and original MRI/clinical outcomes",
      "role": "Required",
      "role_reason": "Distinguish Weight/exposure and original MRI/clinical outcomes to connect materials needed for the selected question with the current materials in this production item.",
      "application_exception": "Preserve the existing ? grade/untested-outcome note for the selected clinical liver outcome and the current MRI report context. Retain gaps in direct cirrhosis/hospitalization/death material, definitions, effects, denominators and duration. Do not substitute MRI/weight/liver-enzyme measures, values, support or safety for direct clinical effects or create new intake/treatment guidance.",
      "criterion": "Weight/exposure and original MRI/clinical outcomes requires corresponding original material/analysis scope and a distinction of unverified matters. Original wording is linked here; content review remains incomplete.",
      "basis": "M03 §3.2.3, M08 §8.2.2–8.2.3; custom application; M08 §8.2.2, M15 §15.3.1; custom application; M03 §3.2.4; custom extension boundary",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed research distinguishing exposure/mediation from actual clinical attribution; no new investigation, calculation or trial is performed now.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "Preserve the original weight description: −1.5±2.6 kg versus −0.2±1.8 kg, correlation with MRI reduction and an unseparated direct liver effect. Do not present direct or mediated effects on clinical disease as verified.",
      "condition_status": "Partly verified",
      "status_reason": "Only corresponding information in the preserved summary is recorded; detailed original materials are unread and content review remains incomplete. Clinical-event correspondence, timing, causal/mediation models and concurrent activity/diet/treatment are unverified. Do not calculate new clinical effects from weight or MRI. Content review remains incomplete.",
      "missingness": "Clinical-event correspondence, timing, causal/mediation models and concurrent activity/diet/treatment are unverified. Do not calculate new clinical effects from weight or MRI.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Timing/correspondence and causal/mediation material for weight/exposure and clinical events"
    },
    {
      "item_id": "N13",
      "question_type": "Evidence condition",
      "question": "Liver enzymes, nonsignificant secondary outcomes and clinical outcomes",
      "needed": "Definitions and results for other measures and disease outcomes",
      "role": "Required",
      "role_reason": "Distinguish Definitions and results for other measures and disease outcomes to connect materials needed for the selected question with the current materials in this production item.",
      "application_exception": "Preserve the existing ? grade/untested-outcome note for the selected clinical liver outcome and the current MRI report context. Retain gaps in direct cirrhosis/hospitalization/death material, definitions, effects, denominators and duration. Do not substitute MRI/weight/liver-enzyme measures, values, support or safety for direct clinical effects or create new intake/treatment guidance.",
      "criterion": "Definitions and results for other measures and disease outcomes requires corresponding original material/analysis scope and a distinction of unverified matters. Original wording is linked here; content review remains incomplete.",
      "basis": "M04 §4.6.3, M15 §15.3.1–15.3.3; status separation is custom design; M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptation is custom design; M15 §15.3.1–15.3.3; custom application; M03 §3.2.4; custom extension boundary",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed research on measure/disease differences and uncertainty; no new investigation, calculation or trial is performed now.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "The original description says other secondary endpoints, including liver enzymes, were nonsignificant. Do not transfer this into verified clinical null effects, an effect of zero or confirmation of MRI benefit.",
      "condition_status": "Partly verified",
      "status_reason": "Only corresponding information in the preserved summary is recorded; detailed original materials are unread and content review remains incomplete. Plans/timepoints, values/denominators/CIs/models for each measure and correspondence with clinical disease events are unverified. Content review remains incomplete.",
      "missingness": "Plans/timepoints, values/denominators/CIs/models for each measure and correspondence with clinical disease events are unverified.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Definitions, original values/estimates and correspondence for other measures and clinical outcomes"
    },
    {
      "item_id": "N14",
      "question_type": "Evidence condition",
      "question": "Subsequent exposure and clinical attribution",
      "needed": "Actual concurrent exposure/treatment and individual course/events",
      "role": "Required",
      "role_reason": "Distinguish Actual concurrent exposure/treatment and individual course/events to connect materials needed for the selected question with the current materials in this production item.",
      "application_exception": "Preserve the existing ? grade/untested-outcome note for the selected clinical liver outcome and the current MRI report context. Retain gaps in direct cirrhosis/hospitalization/death material, definitions, effects, denominators and duration. Do not substitute MRI/weight/liver-enzyme measures, values, support or safety for direct clinical effects or create new intake/treatment guidance.",
      "criterion": "Actual concurrent exposure/treatment and individual course/events requires corresponding original material/analysis scope and a distinction of unverified matters. Original wording is linked here; content review remains incomplete.",
      "basis": "M03 §3.2.3, M08 §8.2.2–8.2.3; custom application; M03 §3.2.2–3.2.3; reverse-direction labeling and test adaptation are custom design; M03 §3.2.1–3.2.4; dose/duration/effect-modification details are custom design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed research on concurrent exposures and attribution of clinical outcomes; no new investigation, calculation or trial is performed now.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "Retain the original quercetin/placebo trial context.",
      "condition_status": "Unverified",
      "status_reason": "Information currently needed is unverified in the preserved summary. Diet/activity/weight management, drugs/tests/treatment, products, individual exposure/adherence and subsequent course for clinical disease are unverified. Do not create treatment, weight-management or product guidance. Content review remains incomplete.",
      "missingness": "Diet/activity/weight management, drugs/tests/treatment, products, individual exposure/adherence and subsequent course for clinical disease are unverified. Do not create treatment, weight-management or product guidance.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Concurrent exposure/treatment and actual course data by direct clinical group"
    },
    {
      "item_id": "N15",
      "question_type": "Evidence condition",
      "question": "Funding/products and scope of originals",
      "needed": "Original trial support disclosures versus direct clinical material",
      "role": "Required",
      "role_reason": "Distinguish Original trial support disclosures versus direct clinical material to connect materials needed for the selected question with the current materials in this production item.",
      "application_exception": "Preserve the existing ? grade/untested-outcome note for the selected clinical liver outcome and the current MRI report context. Retain gaps in direct cirrhosis/hospitalization/death material, definitions, effects, denominators and duration. Do not substitute MRI/weight/liver-enzyme measures, values, support or safety for direct clinical effects or create new intake/treatment guidance.",
      "criterion": "Original trial support disclosures versus direct clinical material requires corresponding original material/analysis scope and a distinction of unverified matters. Original wording is linked here; content review remains incomplete.",
      "basis": "Chamgap independence/attribution conditions. The referenced official method sections do not certify every detail of these items; Data collection/selection principles in M04 §4.5–4.6; Access/reading separation and hyperlink rules are Chamgap design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed research on support/declarations and actual direct material; no new investigation, calculation or trial is performed now.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "The unidentified funding name in public text, undisclosed manufacturer funding/products/analysis, institutional affiliations and no-COI statement are historical descriptions of the original MRI trial.",
      "condition_status": "Partly verified",
      "status_reason": "Only corresponding information in the preserved summary is recorded; detailed original materials are unread and content review remains incomplete. Full disclosures of funding/products, analysis/writing/publication, company/employee authors, contributions and COI in direct clinical trials are unread. Do not fill absent support or current independence from the original declaration. Content review remains incomplete.",
      "missingness": "Full disclosures of funding/products, analysis/writing/publication, company/employee authors, contributions and COI in direct clinical trials are unread. Do not fill absent support or current independence from the original declaration.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original funding/support, contribution/employment and COI disclosures for each clinical trial"
    },
    {
      "item_id": "N16",
      "question_type": "Harm-information gaps supplementing the efficacy table",
      "question": "Clinical harm and safety material",
      "needed": "Definitions, collection and follow-up of harms in direct clinical treatment",
      "role": "Supplementary",
      "role_reason": "Distinguish Definitions, collection and follow-up of harms in direct clinical treatment to connect materials needed for the selected question with the current materials in this production item.",
      "application_exception": "Preserve the existing ? grade/untested-outcome note for the selected clinical liver outcome and the current MRI report context. Retain gaps in direct cirrhosis/hospitalization/death material, definitions, effects, denominators and duration. Do not substitute MRI/weight/liver-enzyme measures, values, support or safety for direct clinical effects or create new intake/treatment guidance.",
      "criterion": "Definitions, collection and follow-up of harms in direct clinical treatment requires corresponding original material/analysis scope and a distinction of unverified matters. Original wording is linked here; content review remains incomplete.",
      "basis": "M19 §19.1.2–19.2.4; detailed distinctions are custom design; M19 §19.1.2–19.2.4; custom application; M19 §19.1.2–19.2.4, M04 §4.6.3; custom application; M19 §19.1.2–19.2.4; custom application; M19 §19.1.2–19.2.4; custom application",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed research on efficacy and actually observed harms by population; no new investigation, calculation or trial is performed now.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "The original MRI trial description of unreported significant safety-metric differences or related adverse events, 41 participants and limits for rare harms belongs to the parent context.",
      "condition_status": "Unverified",
      "status_reason": "Information currently needed is unverified in the preserved summary. Harm denominators/events, discontinuation/relatedness, collection/missingness and long-term/vulnerable populations for the clinical population/period are unverified. Do not turn nonreporting into zero harm or treatment safety. Content review remains incomplete.",
      "missingness": "Harm denominators/events, discontinuation/relatedness, collection/missingness and long-term/vulnerable populations for the clinical population/period are unverified. Do not turn nonreporting into zero harm or treatment safety.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Direct clinical harm collection, group denominators/events, discontinuation and follow-up data"
    },
    {
      "item_id": "N17",
      "question_type": "Evidence condition",
      "question": "Same trial/periods and clinical replication",
      "needed": "Relationships among reports/trials/participants/periods and selected clinical material",
      "role": "Required",
      "role_reason": "Distinguish Relationships among reports/trials/participants/periods and selected clinical material to connect materials needed for the selected question with the current materials in this production item.",
      "application_exception": "Preserve the existing ? grade/untested-outcome note for the selected clinical liver outcome and the current MRI report context. Retain gaps in direct cirrhosis/hospitalization/death material, definitions, effects, denominators and duration. Do not substitute MRI/weight/liver-enzyme measures, values, support or safety for direct clinical effects or create new intake/treatment guidance.",
      "criterion": "Relationships among reports/trials/participants/periods and selected clinical material requires corresponding original material/analysis scope and a distinction of unverified matters. Original wording is linked here; content review remains incomplete.",
      "basis": "M04 §4.6.1–4.6.2 distinction between studies and reports; cohort/outcome linkage is a custom application; M04 §4.6.1–4.6.2, M15 §15.3.1; custom application; M04 §4.5, §4.6.3; limits on current material conversion reflect the review scope and custom design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed research distinguishing the same material from separate clinical replication; no new investigation, calculation or trial is performed now.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "Do not count crossover periods/the same people, MRI/weight/liver enzymes, timepoints or sibling sheets from the sole Li 2024 MRI report as new independent trials or participants. Do not invent long-term clinical follow-up reports.",
      "condition_status": "Partly verified",
      "status_reason": "Only corresponding information in the preserved summary is recorded; detailed original materials are unread and content review remains incomplete. Direct clinical trials/bibliography/registration, unique participants/events, follow-up relationships and independent replication are unverified. Do not inherit original R1/I2 as clinical replication certification. Content review remains incomplete.",
      "missingness": "Direct clinical trials/bibliography/registration, unique participants/events, follow-up relationships and independent replication are unverified. Do not inherit original R1/I2 as clinical replication certification.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Direct clinical report/registration/population/endpoint relationships and separate evidence"
    },
    {
      "item_id": "N18",
      "question_type": "Evidence condition",
      "question": "Generalization across disease, products and duration",
      "needed": "The selected clinical question versus other populations, exposures and durations",
      "role": "Required",
      "role_reason": "Distinguish The selected clinical question versus other populations, exposures and durations to connect materials needed for the selected question with the current materials in this production item.",
      "application_exception": "Preserve the existing ? grade/untested-outcome note for the selected clinical liver outcome and the current MRI report context. Retain gaps in direct cirrhosis/hospitalization/death material, definitions, effects, denominators and duration. Do not substitute MRI/weight/liver-enzyme measures, values, support or safety for direct clinical effects or create new intake/treatment guidance.",
      "criterion": "The selected clinical question versus other populations, exposures and durations requires corresponding original material/analysis scope and a distinction of unverified matters. Original wording is linked here; content review remains incomplete.",
      "basis": "M03 §3.2.1; detailed population conditions are custom design; M03 §3.2.2–3.2.3; reverse-direction labeling and test adaptation are custom design; M03 §3.2.1–3.2.4; dose/duration/effect-modification details are custom design; M03 §3.2.4; custom extension boundary",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed research on the selected question and other conditions; no new investigation, calculation or trial is performed now.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "The specific 500 mg/12-week MRI result does not support every polyphenol or improvement in cirrhosis, hospitalization or death.",
      "condition_status": "Partly verified",
      "status_reason": "Only corresponding information in the preserved summary is recorded; detailed original materials are unread and content review remains incomplete. Direct material for other formulations/doses, disease stages/populations and long-term effects/harms is unverified. Do not create new drug, intake or treatment methods. Content review remains incomplete.",
      "missingness": "Direct material for other formulations/doses, disease stages/populations and long-term effects/harms is unverified. Do not create new drug, intake or treatment methods.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Direct clinical and harm material by disease/formulation/duration"
    },
    {
      "item_id": "N19",
      "question_type": "Evidence condition",
      "question": "Original subclaim ? grade, parent C54 and history",
      "needed": "Original subclaim values/absences, parent axes, Korean/English text, dates and corrections",
      "role": "Required",
      "role_reason": "Distinguish Original subclaim values/absences, parent axes, Korean/English text, dates and corrections to connect materials needed for the selected question with the current materials in this production item.",
      "application_exception": "Preserve the existing ? grade/untested-outcome note for the selected clinical liver outcome and the current MRI report context. Retain gaps in direct cirrhosis/hospitalization/death material, definitions, effects, denominators and duration. Do not substitute MRI/weight/liver-enzyme measures, values, support or safety for direct clinical effects or create new intake/treatment guidance.",
      "criterion": "Original subclaim values/absences, parent axes, Korean/English text, dates and corrections requires corresponding original material/analysis scope and a distinction of unverified matters. Original wording is linked here; content review remains incomplete.",
      "basis": "M04 §4.5, §4.6.3; limits of this material conversion follow the review scope and internal design; M03 §3.1, §3.2.1–3.2.4 question-clarification principles; detailed separation rules are internally designed",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Propose update research on source-material changes and production versions; no new investigation, calculation or trial is performed now.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "Preserve the subclaim ? grade and untested-outcome note, parent C54/Good, original assessment axes/Korean and English text, 2026-08-26 and empty correction/deliberation records in the full preserved summary.",
      "condition_status": "Partly verified",
      "status_reason": "Only corresponding information in the preserved summary is recorded; detailed original materials are unread and content review remains incomplete. Do not fill absent subclaim scores/status/axes or the parent’s unrecorded classification information. Do not promote historical cross-validation, abstract/public-table/paper descriptions into current clinical original reading, review or condition fulfillment. Content review remains incomplete.",
      "missingness": "Do not fill absent subclaim scores/status/axes or the parent’s unrecorded classification information. Do not promote historical cross-validation, abstract/public-table/paper descriptions into current clinical original reading, review or condition fulfillment.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original assessment, correction/change text and user input"
    },
    {
      "item_id": "N20",
      "question_type": "Evidence condition",
      "question": "Summary/bibliography and gaps in direct clinical material",
      "needed": "Actual reading/URLs for each material and selected clinical material",
      "role": "Required",
      "role_reason": "Distinguish Actual reading/URLs for each material and selected clinical material to connect materials needed for the selected question with the current materials in this production item.",
      "application_exception": "Preserve the existing ? grade/untested-outcome note for the selected clinical liver outcome and the current MRI report context. Retain gaps in direct cirrhosis/hospitalization/death material, definitions, effects, denominators and duration. Do not substitute MRI/weight/liver-enzyme measures, values, support or safety for direct clinical effects or create new intake/treatment guidance.",
      "criterion": "Actual reading/URLs for each material and selected clinical material requires corresponding original material/analysis scope and a distinction of unverified matters. Original wording is linked here; content review remains incomplete.",
      "basis": "M04 §4.5–4.6 material-collection/selection principles; separation of access/reading and hyperlink conventions are custom design; M04 §4.5, §4.6.3; limits on current material conversion reflect the review scope and custom design; M03 §3.1, §3.2.1–3.2.4 question-clarification principles; detailed separation rules are custom design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Propose scoped update research based on materials actually acquired; no new investigation, calculation or trial is performed now.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "Link the preserved summary with Li 2024/PMID 39032786 MRI bibliography/URL. They do not replace direct material or links for clinical disease outcomes.",
      "condition_status": "Partly verified",
      "status_reason": "Only corresponding information in the preserved summary is recorded; detailed original materials are unread and content review remains incomplete. Direct clinical material and the original MRI paper/registration/protocol/SAP/disclosures are unread; access was not attempted. Do not upgrade current acquisition/reading/review status using original links/identifiers; links/clicks are not checked. Content review remains incomplete.",
      "missingness": "Direct clinical material and the original MRI paper/registration/protocol/SAP/disclosures are unread; access was not attempted. Do not upgrade current acquisition/reading/review status using original links/identifiers; links/clicks are not checked.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Direct original clinical reports, registration/plans/disclosures and user input"
    }
  ],
  "reports": [
    {
      "report_id": "S01",
      "title": "Li N et al. 2024",
      "url": "https://pubmed.ncbi.nlm.nih.gov/39032786/",
      "report_type": "Randomized double-blind placebo-controlled crossover trial",
      "existence": "Stored bibliography exists; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "study_family": "RG2955-LI-2024",
      "independent_replication": null,
      "observed_result": "The preserved result of this report is the MRI surrogate 11.5%±6.4→9.6%±5.8 versus placebo change −0.1%±2.6; P=0.013, adjusted P=0.028. These are not effect values for the selected clinical cirrhosis, hospitalization or death outcomes. Preserve the existing ? grade/untested-outcome note and unverified direct clinical definitions, populations, events/denominators, duration/estimates/CIs and plans.",
      "result_level": "Outcome wording in the stored summary",
      "source_evidence_date": "2026-08-26",
      "materials": [
        {
          "material_type": "Stored summary",
          "public_status": "Stored file",
          "access_status": "Stored summary",
          "acquired": true,
          "actually_read": "Summary read",
          "as_of": "2026-08-26",
          "qualification": "Only stored-summary and bibliographic content was used for production. External material verification/review is not complete."
        },
        {
          "material_type": "External paper",
          "public_status": "Public availability unverified; only bibliography links preserved",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-08-26",
          "qualification": "No external access or click testing was performed in the original preparation. URLs or registration identifiers alone do not upgrade acquisition/reading status."
        },
        {
          "material_type": "Registration material",
          "public_status": "Public availability unverified; only bibliography links preserved",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-08-26",
          "qualification": "No external access or click testing was performed in the original preparation. URLs or registration identifiers alone do not upgrade acquisition/reading status."
        },
        {
          "material_type": "Protocol",
          "public_status": "Public availability unverified; only bibliography links preserved",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-08-26",
          "qualification": "No external access or click testing was performed in the original preparation. URLs or registration identifiers alone do not upgrade acquisition/reading status."
        },
        {
          "material_type": "Statistical analysis plan",
          "public_status": "Public availability unverified; only bibliography links preserved",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-08-26",
          "qualification": "No external access or click testing was performed in the original preparation. URLs or registration identifiers alone do not upgrade acquisition/reading status."
        },
        {
          "material_type": "Funding, product-support and COI material",
          "public_status": "Public availability unverified; only bibliography links preserved",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-08-26",
          "qualification": "No external access or click testing was performed in the original preparation. URLs or registration identifiers alone do not upgrade acquisition/reading status."
        }
      ],
      "links": [
        {
          "label": "PubMed",
          "url": "https://pubmed.ncbi.nlm.nih.gov/39032786/"
        }
      ]
    }
  ],
  "method_sources": [
    {
      "id": "M03",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03",
      "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13",
      "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.",
      "review_level": "Preserved method HTML copies; no current method-content re-review or official tool execution"
    },
    {
      "id": "M04",
      "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04",
      "section": "§4.5, §4.6.1–4.6.3, MECIR C42",
      "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.",
      "review_level": "Preserved method HTML copies; no current method-content re-review or official tool execution"
    },
    {
      "id": "M08",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08",
      "section": "§8.1–8.2.3, Table 8.2.a",
      "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.",
      "review_level": "Preserved method HTML copies; no current method-content re-review or official tool execution"
    },
    {
      "id": "M15",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15",
      "section": "§15.2.4, §15.3.1–15.3.3",
      "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.",
      "review_level": "Preserved method HTML copies; no current method-content re-review or official tool execution"
    },
    {
      "id": "M19",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19",
      "section": "§19.1.2, §19.2.1–19.2.4",
      "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.",
      "review_level": "Preserved method HTML copies; no current method-content re-review or official tool execution"
    }
  ],
  "status_dictionary": {
    "Met": "Status for necessary evidence confirmed after existing content review. No completion is declared in the current presentation.",
    "Partly verified": "Some information in the stored summary is linked into the table. External comparison/content review is not complete.",
    "Unverified": "The article leaves this unverified, or required material is absent from the current stored summary. This is distinct from zero, absence or safety.",
    "Review incomplete": "Existing content review remains incomplete.",
    "Not reported": "Not reported within the stored material actually read; not extended to the entire primary paper.",
    "Inaccessible": "Means an actual access failure. Access not attempted here is not assigned this state.",
    "Not applicable": "Not used as a substitute for an evidence gap.",
    "Conflicting data": "Requires an observed disagreement under the same comparison criteria; not automatically judged in this production.",
    "Insufficient evidence for the conditions": "Marks a gap in additional material required by the selected conditions; not a new efficacy grade."
  },
  "study_overlap": {
    "state": "Unverified",
    "unique_trial_count": null,
    "unique_participant_count": null,
    "reason": "S01 Li 2024/ChiCTR2100047904 is a single double-blind placebo-controlled crossover trial in nonalcoholic fatty liver disease, with 41 randomized and 36 completed. Distinguish original quercetin 500 mg/day, 12-week intervention and crossover after a 4-week washout from unverified actual sequence/period/exposure and ITT/observation/missing-data models. Quercetin-period MRI 11.5%±6.4 to 9.6%±5.8, original approximate −1.9 percentage points, placebo change −0.1%±2.6, P=.013 and adjusted P=.028 are original surrogate results, not new calculations. Do not arbitrarily correct %/%p wording; retain gaps in the type of ± quantity, between-treatment CI/important difference and original period/within-person estimates. Weight changes −1.5±2.6 kg versus −0.2±1.8 kg, correlation with MRI reduction/unseparated direct hepatic effects, nonsignificant liver enzymes/other secondary outcomes and untested clinical cirrhosis/hospitalization/death are distinct outcomes. Do not sum the same participants/arms, crossover periods, MRI/weight/liver enzymes, citations or sibling sheets as new independent trials/participants. Do not create follow-up reports/clinical effects or inherit original R1/I2 and historical abstract/public-table/full-text checking accounts as current review/external reading. Report/material-slot counts are not unique clinical trial/participant/independent-replication totals; no new sums or independence certification are performed."
  },
  "history": [
    {
      "date": "2026-10-12",
      "kind": "Separation of public-facing pages and materials",
      "view_version": "1.0",
      "change": "Public-facing pages and materials were prepared from the existing 20 items. No new clinical search, verification-status change or scoring was performed."
    }
  ],
  "language": "en",
  "translation_date": "2026-10-12"
}