{
  "schema_version": "chamgap-public-criteria-1.0",
  "title": "Quercetin 500 mg daily × Improved clinical liver outcomes — Evidence Check",
  "language": "en",
  "translation_date": "2026-10-12",
  "criteria_version": "1.0",
  "criteria_date": "2026-10-06",
  "condition_origin": "Chamgap's own application conditions",
  "method_sources": [
    {
      "id": "M03",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03",
      "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13",
      "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.",
      "review_level": "Preserved method HTML copies; no current method-content re-review or official tool execution"
    },
    {
      "id": "M04",
      "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04",
      "section": "§4.5, §4.6.1–4.6.3, MECIR C42",
      "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.",
      "review_level": "Preserved method HTML copies; no current method-content re-review or official tool execution"
    },
    {
      "id": "M08",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08",
      "section": "§8.1–8.2.3, Table 8.2.a",
      "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.",
      "review_level": "Preserved method HTML copies; no current method-content re-review or official tool execution"
    },
    {
      "id": "M15",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15",
      "section": "§15.2.4, §15.3.1–15.3.3",
      "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.",
      "review_level": "Preserved method HTML copies; no current method-content re-review or official tool execution"
    },
    {
      "id": "M19",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19",
      "section": "§19.1.2, §19.2.1–19.2.4",
      "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.",
      "review_level": "Preserved method HTML copies; no current method-content re-review or official tool execution"
    }
  ],
  "status_dictionary": {
    "Met": "Status for necessary evidence confirmed after existing content review. No completion is declared in the current presentation.",
    "Partly verified": "Some information in the stored summary is linked into the table. External comparison/content review is not complete.",
    "Unverified": "The article leaves this unverified, or required material is absent from the current stored summary. This is distinct from zero, absence or safety.",
    "Review incomplete": "Existing content review remains incomplete.",
    "Not reported": "Not reported within the stored material actually read; not extended to the entire primary paper.",
    "Inaccessible": "Means an actual access failure. Access not attempted here is not assigned this state.",
    "Not applicable": "Not used as a substitute for an evidence gap.",
    "Conflicting data": "Requires an observed disagreement under the same comparison criteria; not automatically judged in this production.",
    "Insufficient evidence for the conditions": "Marks a gap in additional material required by the selected conditions; not a new efficacy grade."
  },
  "requirements": [
    {
      "item_id": "N01",
      "question_type": "Evidence condition",
      "question": "Selected clinical liver outcome and original values",
      "needed": "Existing question, grade and note; parent context and absent fields",
      "role": "Required",
      "role_reason": "Distinguish Existing question, grade and note; parent context and absent fields to connect materials needed for the selected question with the current materials in this production item.",
      "application_exception": "Preserve the existing ? grade/untested-outcome note for the selected clinical liver outcome and the current MRI report context. Retain gaps in direct cirrhosis/hospitalization/death material, definitions, effects, denominators and duration. Do not substitute MRI/weight/liver-enzyme measures, values, support or safety for direct clinical effects or create new intake/treatment guidance.",
      "criterion": "Existing question, grade and note; parent context and absent fields requires corresponding original material/analysis scope and a distinction of unverified matters. Original wording is linked here; content review remains incomplete.",
      "basis": "M03 §3.1, §3.2.1–3.2.4 question-clarification principles; detailed separation rules are custom design; M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptation is custom design; M04 §4.5, §4.6.3; limits on current material conversion reflect the review scope and custom design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Connect the original question to additional materials in proposed update research; no new investigation, calculation or trial is performed now."
    },
    {
      "item_id": "N02",
      "question_type": "Evidence condition",
      "question": "Clinical outcomes: definitions and measurement",
      "needed": "Definitions and adjudication of original outcomes such as cirrhosis, hospitalization and death",
      "role": "Required",
      "role_reason": "Distinguish Definitions and adjudication of original outcomes such as cirrhosis, hospitalization and death to connect materials needed for the selected question with the current materials in this production item.",
      "application_exception": "Preserve the existing ? grade/untested-outcome note for the selected clinical liver outcome and the current MRI report context. Retain gaps in direct cirrhosis/hospitalization/death material, definitions, effects, denominators and duration. Do not substitute MRI/weight/liver-enzyme measures, values, support or safety for direct clinical effects or create new intake/treatment guidance.",
      "criterion": "Definitions and adjudication of original outcomes such as cirrhosis, hospitalization and death requires corresponding original material/analysis scope and a distinction of unverified matters. Original wording is linked here; content review remains incomplete.",
      "basis": "M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptation is custom design; M08 Table 8.2.a, M03 §3.2.4; custom application; M03 §3.2.4; custom extension boundary; M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; design-specific adaptation is custom design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed research distinguishing imaging/laboratory measures from clinical outcomes; no new investigation, calculation or trial is performed now."
    },
    {
      "item_id": "N03",
      "question_type": "Evidence condition",
      "question": "Participants, disease and risk scope",
      "needed": "Original MRI participants and the population analyzed for clinical outcomes",
      "role": "Required",
      "role_reason": "Distinguish Original MRI participants and the population analyzed for clinical outcomes to connect materials needed for the selected question with the current materials in this production item.",
      "application_exception": "Preserve the existing ? grade/untested-outcome note for the selected clinical liver outcome and the current MRI report context. Retain gaps in direct cirrhosis/hospitalization/death material, definitions, effects, denominators and duration. Do not substitute MRI/weight/liver-enzyme measures, values, support or safety for direct clinical effects or create new intake/treatment guidance.",
      "criterion": "Original MRI participants and the population analyzed for clinical outcomes requires corresponding original material/analysis scope and a distinction of unverified matters. Original wording is linked here; content review remains incomplete.",
      "basis": "M03 §3.2.1; detailed population conditions are custom design; M03 §3.2.1–3.2.4; dose/duration/effect-modification details are custom design; M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; design-specific adaptation is custom design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed research on disease/population and the applicability of clinical effects; no new investigation, calculation or trial is performed now."
    },
    {
      "item_id": "N04",
      "question_type": "Evidence condition",
      "question": "Quercetin and direct clinical intervention",
      "needed": "Formulation, dose, strategy and actual clinical comparison",
      "role": "Required",
      "role_reason": "Distinguish Formulation, dose, strategy and actual clinical comparison to connect materials needed for the selected question with the current materials in this production item.",
      "application_exception": "Preserve the existing ? grade/untested-outcome note for the selected clinical liver outcome and the current MRI report context. Retain gaps in direct cirrhosis/hospitalization/death material, definitions, effects, denominators and duration. Do not substitute MRI/weight/liver-enzyme measures, values, support or safety for direct clinical effects or create new intake/treatment guidance.",
      "criterion": "Formulation, dose, strategy and actual clinical comparison requires corresponding original material/analysis scope and a distinction of unverified matters. Original wording is linked here; content review remains incomplete.",
      "basis": "M03 §3.2.2–3.2.3; reverse-direction labels and checking adaptations are internally designed; M03 §3.2.3, M08 §8.2.2–8.2.3; internal application; M03 §3.2.1–3.2.4; dose, duration and effect-modification details are internally designed",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed research on formulation/strategy and attribution to the clinical question; no new investigation, calculation or trial is performed now."
    },
    {
      "item_id": "N05",
      "question_type": "Evidence condition",
      "question": "Direct bibliography, registration and report relationships",
      "needed": "Direct original reports, registration and correspondence for the selected clinical question",
      "role": "Required",
      "role_reason": "Distinguish Direct original reports, registration and correspondence for the selected clinical question to connect materials needed for the selected question with the current materials in this production item.",
      "application_exception": "Preserve the existing ? grade/untested-outcome note for the selected clinical liver outcome and the current MRI report context. Retain gaps in direct cirrhosis/hospitalization/death material, definitions, effects, denominators and duration. Do not substitute MRI/weight/liver-enzyme measures, values, support or safety for direct clinical effects or create new intake/treatment guidance.",
      "criterion": "Direct original reports, registration and correspondence for the selected clinical question requires corresponding original material/analysis scope and a distinction of unverified matters. Original wording is linked here; content review remains incomplete.",
      "basis": "M04 §4.5–4.6 material-collection/selection principles; separation of access/reading and hyperlink conventions are custom design; M04 §4.6.1–4.6.2 distinction between studies and reports; cohort/outcome linkage is a custom application; M03 §3.1, §3.2.1–3.2.4 question-clarification principles; detailed separation rules are custom design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed research linking the original text/assessment with direct reports; no new investigation, calculation or trial is performed now."
    },
    {
      "item_id": "N06",
      "question_type": "Evidence condition",
      "question": "Original MRI values and clinical effects",
      "needed": "Surrogate comparisons/timing and their relationship to clinical outcomes",
      "role": "Required",
      "role_reason": "Distinguish Surrogate comparisons/timing and their relationship to clinical outcomes to connect materials needed for the selected question with the current materials in this production item.",
      "application_exception": "Preserve the existing ? grade/untested-outcome note for the selected clinical liver outcome and the current MRI report context. Retain gaps in direct cirrhosis/hospitalization/death material, definitions, effects, denominators and duration. Do not substitute MRI/weight/liver-enzyme measures, values, support or safety for direct clinical effects or create new intake/treatment guidance.",
      "criterion": "Surrogate comparisons/timing and their relationship to clinical outcomes requires corresponding original material/analysis scope and a distinction of unverified matters. Original wording is linked here; content review remains incomplete.",
      "basis": "M03 §3.2.4; custom extension boundary; M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptation is custom design; M04 §4.6.3, M15 §15.3.1–15.3.3; status separation is custom design; M15 §15.3.1–15.3.3; custom application",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed research distinguishing surrogate results from actual disease outcomes; no new investigation, calculation or trial is performed now."
    },
    {
      "item_id": "N07",
      "question_type": "Evidence condition",
      "question": "Between-group clinical effects, CIs and thresholds",
      "needed": "Direct clinical effect/precision and prespecified important difference",
      "role": "Required",
      "role_reason": "Distinguish Direct clinical effect/precision and prespecified important difference to connect materials needed for the selected question with the current materials in this production item.",
      "application_exception": "Preserve the existing ? grade/untested-outcome note for the selected clinical liver outcome and the current MRI report context. Retain gaps in direct cirrhosis/hospitalization/death material, definitions, effects, denominators and duration. Do not substitute MRI/weight/liver-enzyme measures, values, support or safety for direct clinical effects or create new intake/treatment guidance.",
      "criterion": "Direct clinical effect/precision and prespecified important difference requires corresponding original material/analysis scope and a distinction of unverified matters. Original wording is linked here; content review remains incomplete.",
      "basis": "M15 §15.3.1–15.3.3; custom application; M08 Table 8.2.a, M04 §4.6.3; custom application; M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; design-specific adaptation is custom design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed research distinguishing clinical uncertainty from clinical meaning; no new investigation, calculation or trial is performed now."
    },
    {
      "item_id": "N08",
      "question_type": "Evidence condition",
      "question": "Clinical timing and long-term follow-up",
      "needed": "Specifications for event occurrence, exposure, follow-up and censoring",
      "role": "Required",
      "role_reason": "Distinguish Specifications for event occurrence, exposure, follow-up and censoring to connect materials needed for the selected question with the current materials in this production item.",
      "application_exception": "Preserve the existing ? grade/untested-outcome note for the selected clinical liver outcome and the current MRI report context. Retain gaps in direct cirrhosis/hospitalization/death material, definitions, effects, denominators and duration. Do not substitute MRI/weight/liver-enzyme measures, values, support or safety for direct clinical effects or create new intake/treatment guidance.",
      "criterion": "Specifications for event occurrence, exposure, follow-up and censoring requires corresponding original material/analysis scope and a distinction of unverified matters. Original wording is linked here; content review remains incomplete.",
      "basis": "M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptation is custom design; M03 §3.2.1–3.2.4; dose/duration/effect-modification details are custom design; M08 §8.2.2, M15 §15.3.1; custom application; M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; design-specific adaptation is custom design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed follow-up research distinguishing duration from disease outcomes; no new investigation, calculation or trial is performed now."
    },
    {
      "item_id": "N09",
      "question_type": "Evidence condition",
      "question": "Clinical participants/events, denominators and missingness",
      "needed": "Randomized, observed and analyzed units and clinical-event units",
      "role": "Required",
      "role_reason": "Distinguish Randomized, observed and analyzed units and clinical-event units to connect materials needed for the selected question with the current materials in this production item.",
      "application_exception": "Preserve the existing ? grade/untested-outcome note for the selected clinical liver outcome and the current MRI report context. Retain gaps in direct cirrhosis/hospitalization/death material, definitions, effects, denominators and duration. Do not substitute MRI/weight/liver-enzyme measures, values, support or safety for direct clinical effects or create new intake/treatment guidance.",
      "criterion": "Randomized, observed and analyzed units and clinical-event units requires corresponding original material/analysis scope and a distinction of unverified matters. Original wording is linked here; content review remains incomplete.",
      "basis": "M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; design-specific adaptation is custom design; M08 §8.2.2, M15 §15.3.1; custom application; M04 §4.6.1–4.6.2 distinction between studies and reports; cohort/outcome linkage is a custom application",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed research on population/event units and missing-data assumptions; no new investigation, calculation or trial is performed now."
    },
    {
      "item_id": "N10",
      "question_type": "Evidence condition",
      "question": "Original allocation/blinding and clinical adjudication",
      "needed": "Allocation, measurement and analysis procedures in direct clinical trials",
      "role": "Required",
      "role_reason": "Distinguish Allocation, measurement and analysis procedures in direct clinical trials to connect materials needed for the selected question with the current materials in this production item.",
      "application_exception": "Preserve the existing ? grade/untested-outcome note for the selected clinical liver outcome and the current MRI report context. Retain gaps in direct cirrhosis/hospitalization/death material, definitions, effects, denominators and duration. Do not substitute MRI/weight/liver-enzyme measures, values, support or safety for direct clinical effects or create new intake/treatment guidance.",
      "criterion": "Allocation, measurement and analysis procedures in direct clinical trials requires corresponding original material/analysis scope and a distinction of unverified matters. Original wording is linked here; content review remains incomplete.",
      "basis": "M08 §8.1–8.2.3; custom application; M08 Table 8.2.a, M03 §3.2.4; custom application; M08 §8.2.2, M15 §15.3.1; custom application; M04 §4.5–4.6 material-collection/selection principles; separation of access/reading and hyperlink conventions are custom design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed research on procedures and clinically observed outcomes; no new investigation, calculation or trial is performed now."
    },
    {
      "item_id": "N11",
      "question_type": "Evidence condition",
      "question": "Clinical registration and prespecified plans",
      "needed": "Registration/hierarchy, analysis and changes for the selected clinical endpoint",
      "role": "Required",
      "role_reason": "Distinguish Registration/hierarchy, analysis and changes for the selected clinical endpoint to connect materials needed for the selected question with the current materials in this production item.",
      "application_exception": "Preserve the existing ? grade/untested-outcome note for the selected clinical liver outcome and the current MRI report context. Retain gaps in direct cirrhosis/hospitalization/death material, definitions, effects, denominators and duration. Do not substitute MRI/weight/liver-enzyme measures, values, support or safety for direct clinical effects or create new intake/treatment guidance.",
      "criterion": "Registration/hierarchy, analysis and changes for the selected clinical endpoint requires corresponding original material/analysis scope and a distinction of unverified matters. Original wording is linked here; content review remains incomplete.",
      "basis": "M08 Table 8.2.a, M04 §4.6.3; custom application; M04 §4.5–4.6 material-collection/selection principles; separation of access/reading and hyperlink conventions are custom design; M04 §4.5, §4.6.3; limits on current material conversion reflect the review scope and custom design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed research linking prespecified plans with clinical reports; no new investigation, calculation or trial is performed now."
    },
    {
      "item_id": "N12",
      "question_type": "Evidence condition",
      "question": "Weight mediation and direct liver effects",
      "needed": "Weight/exposure and original MRI/clinical outcomes",
      "role": "Required",
      "role_reason": "Distinguish Weight/exposure and original MRI/clinical outcomes to connect materials needed for the selected question with the current materials in this production item.",
      "application_exception": "Preserve the existing ? grade/untested-outcome note for the selected clinical liver outcome and the current MRI report context. Retain gaps in direct cirrhosis/hospitalization/death material, definitions, effects, denominators and duration. Do not substitute MRI/weight/liver-enzyme measures, values, support or safety for direct clinical effects or create new intake/treatment guidance.",
      "criterion": "Weight/exposure and original MRI/clinical outcomes requires corresponding original material/analysis scope and a distinction of unverified matters. Original wording is linked here; content review remains incomplete.",
      "basis": "M03 §3.2.3, M08 §8.2.2–8.2.3; custom application; M08 §8.2.2, M15 §15.3.1; custom application; M03 §3.2.4; custom extension boundary",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed research distinguishing exposure/mediation from actual clinical attribution; no new investigation, calculation or trial is performed now."
    },
    {
      "item_id": "N13",
      "question_type": "Evidence condition",
      "question": "Liver enzymes, nonsignificant secondary outcomes and clinical outcomes",
      "needed": "Definitions and results for other measures and disease outcomes",
      "role": "Required",
      "role_reason": "Distinguish Definitions and results for other measures and disease outcomes to connect materials needed for the selected question with the current materials in this production item.",
      "application_exception": "Preserve the existing ? grade/untested-outcome note for the selected clinical liver outcome and the current MRI report context. Retain gaps in direct cirrhosis/hospitalization/death material, definitions, effects, denominators and duration. Do not substitute MRI/weight/liver-enzyme measures, values, support or safety for direct clinical effects or create new intake/treatment guidance.",
      "criterion": "Definitions and results for other measures and disease outcomes requires corresponding original material/analysis scope and a distinction of unverified matters. Original wording is linked here; content review remains incomplete.",
      "basis": "M04 §4.6.3, M15 §15.3.1–15.3.3; status separation is custom design; M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptation is custom design; M15 §15.3.1–15.3.3; custom application; M03 §3.2.4; custom extension boundary",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed research on measure/disease differences and uncertainty; no new investigation, calculation or trial is performed now."
    },
    {
      "item_id": "N14",
      "question_type": "Evidence condition",
      "question": "Subsequent exposure and clinical attribution",
      "needed": "Actual concurrent exposure/treatment and individual course/events",
      "role": "Required",
      "role_reason": "Distinguish Actual concurrent exposure/treatment and individual course/events to connect materials needed for the selected question with the current materials in this production item.",
      "application_exception": "Preserve the existing ? grade/untested-outcome note for the selected clinical liver outcome and the current MRI report context. Retain gaps in direct cirrhosis/hospitalization/death material, definitions, effects, denominators and duration. Do not substitute MRI/weight/liver-enzyme measures, values, support or safety for direct clinical effects or create new intake/treatment guidance.",
      "criterion": "Actual concurrent exposure/treatment and individual course/events requires corresponding original material/analysis scope and a distinction of unverified matters. Original wording is linked here; content review remains incomplete.",
      "basis": "M03 §3.2.3, M08 §8.2.2–8.2.3; custom application; M03 §3.2.2–3.2.3; reverse-direction labeling and test adaptation are custom design; M03 §3.2.1–3.2.4; dose/duration/effect-modification details are custom design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed research on concurrent exposures and attribution of clinical outcomes; no new investigation, calculation or trial is performed now."
    },
    {
      "item_id": "N15",
      "question_type": "Evidence condition",
      "question": "Funding/products and scope of originals",
      "needed": "Original trial support disclosures versus direct clinical material",
      "role": "Required",
      "role_reason": "Distinguish Original trial support disclosures versus direct clinical material to connect materials needed for the selected question with the current materials in this production item.",
      "application_exception": "Preserve the existing ? grade/untested-outcome note for the selected clinical liver outcome and the current MRI report context. Retain gaps in direct cirrhosis/hospitalization/death material, definitions, effects, denominators and duration. Do not substitute MRI/weight/liver-enzyme measures, values, support or safety for direct clinical effects or create new intake/treatment guidance.",
      "criterion": "Original trial support disclosures versus direct clinical material requires corresponding original material/analysis scope and a distinction of unverified matters. Original wording is linked here; content review remains incomplete.",
      "basis": "Chamgap independence/attribution conditions. The referenced official method sections do not certify every detail of these items; Data collection/selection principles in M04 §4.5–4.6; Access/reading separation and hyperlink rules are Chamgap design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed research on support/declarations and actual direct material; no new investigation, calculation or trial is performed now."
    },
    {
      "item_id": "N16",
      "question_type": "Harm-information gaps supplementing the efficacy table",
      "question": "Clinical harm and safety material",
      "needed": "Definitions, collection and follow-up of harms in direct clinical treatment",
      "role": "Supplementary",
      "role_reason": "Distinguish Definitions, collection and follow-up of harms in direct clinical treatment to connect materials needed for the selected question with the current materials in this production item.",
      "application_exception": "Preserve the existing ? grade/untested-outcome note for the selected clinical liver outcome and the current MRI report context. Retain gaps in direct cirrhosis/hospitalization/death material, definitions, effects, denominators and duration. Do not substitute MRI/weight/liver-enzyme measures, values, support or safety for direct clinical effects or create new intake/treatment guidance.",
      "criterion": "Definitions, collection and follow-up of harms in direct clinical treatment requires corresponding original material/analysis scope and a distinction of unverified matters. Original wording is linked here; content review remains incomplete.",
      "basis": "M19 §19.1.2–19.2.4; detailed distinctions are custom design; M19 §19.1.2–19.2.4; custom application; M19 §19.1.2–19.2.4, M04 §4.6.3; custom application; M19 §19.1.2–19.2.4; custom application; M19 §19.1.2–19.2.4; custom application",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed research on efficacy and actually observed harms by population; no new investigation, calculation or trial is performed now."
    },
    {
      "item_id": "N17",
      "question_type": "Evidence condition",
      "question": "Same trial/periods and clinical replication",
      "needed": "Relationships among reports/trials/participants/periods and selected clinical material",
      "role": "Required",
      "role_reason": "Distinguish Relationships among reports/trials/participants/periods and selected clinical material to connect materials needed for the selected question with the current materials in this production item.",
      "application_exception": "Preserve the existing ? grade/untested-outcome note for the selected clinical liver outcome and the current MRI report context. Retain gaps in direct cirrhosis/hospitalization/death material, definitions, effects, denominators and duration. Do not substitute MRI/weight/liver-enzyme measures, values, support or safety for direct clinical effects or create new intake/treatment guidance.",
      "criterion": "Relationships among reports/trials/participants/periods and selected clinical material requires corresponding original material/analysis scope and a distinction of unverified matters. Original wording is linked here; content review remains incomplete.",
      "basis": "M04 §4.6.1–4.6.2 distinction between studies and reports; cohort/outcome linkage is a custom application; M04 §4.6.1–4.6.2, M15 §15.3.1; custom application; M04 §4.5, §4.6.3; limits on current material conversion reflect the review scope and custom design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed research distinguishing the same material from separate clinical replication; no new investigation, calculation or trial is performed now."
    },
    {
      "item_id": "N18",
      "question_type": "Evidence condition",
      "question": "Generalization across disease, products and duration",
      "needed": "The selected clinical question versus other populations, exposures and durations",
      "role": "Required",
      "role_reason": "Distinguish The selected clinical question versus other populations, exposures and durations to connect materials needed for the selected question with the current materials in this production item.",
      "application_exception": "Preserve the existing ? grade/untested-outcome note for the selected clinical liver outcome and the current MRI report context. Retain gaps in direct cirrhosis/hospitalization/death material, definitions, effects, denominators and duration. Do not substitute MRI/weight/liver-enzyme measures, values, support or safety for direct clinical effects or create new intake/treatment guidance.",
      "criterion": "The selected clinical question versus other populations, exposures and durations requires corresponding original material/analysis scope and a distinction of unverified matters. Original wording is linked here; content review remains incomplete.",
      "basis": "M03 §3.2.1; detailed population conditions are custom design; M03 §3.2.2–3.2.3; reverse-direction labeling and test adaptation are custom design; M03 §3.2.1–3.2.4; dose/duration/effect-modification details are custom design; M03 §3.2.4; custom extension boundary",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Proposed research on the selected question and other conditions; no new investigation, calculation or trial is performed now."
    },
    {
      "item_id": "N19",
      "question_type": "Evidence condition",
      "question": "Original subclaim ? grade, parent C54 and history",
      "needed": "Original subclaim values/absences, parent axes, Korean/English text, dates and corrections",
      "role": "Required",
      "role_reason": "Distinguish Original subclaim values/absences, parent axes, Korean/English text, dates and corrections to connect materials needed for the selected question with the current materials in this production item.",
      "application_exception": "Preserve the existing ? grade/untested-outcome note for the selected clinical liver outcome and the current MRI report context. Retain gaps in direct cirrhosis/hospitalization/death material, definitions, effects, denominators and duration. Do not substitute MRI/weight/liver-enzyme measures, values, support or safety for direct clinical effects or create new intake/treatment guidance.",
      "criterion": "Original subclaim values/absences, parent axes, Korean/English text, dates and corrections requires corresponding original material/analysis scope and a distinction of unverified matters. Original wording is linked here; content review remains incomplete.",
      "basis": "M04 §4.5, §4.6.3; limits of this material conversion follow the review scope and internal design; M03 §3.1, §3.2.1–3.2.4 question-clarification principles; detailed separation rules are internally designed",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Propose update research on source-material changes and production versions; no new investigation, calculation or trial is performed now."
    },
    {
      "item_id": "N20",
      "question_type": "Evidence condition",
      "question": "Summary/bibliography and gaps in direct clinical material",
      "needed": "Actual reading/URLs for each material and selected clinical material",
      "role": "Required",
      "role_reason": "Distinguish Actual reading/URLs for each material and selected clinical material to connect materials needed for the selected question with the current materials in this production item.",
      "application_exception": "Preserve the existing ? grade/untested-outcome note for the selected clinical liver outcome and the current MRI report context. Retain gaps in direct cirrhosis/hospitalization/death material, definitions, effects, denominators and duration. Do not substitute MRI/weight/liver-enzyme measures, values, support or safety for direct clinical effects or create new intake/treatment guidance.",
      "criterion": "Actual reading/URLs for each material and selected clinical material requires corresponding original material/analysis scope and a distinction of unverified matters. Original wording is linked here; content review remains incomplete.",
      "basis": "M04 §4.5–4.6 material-collection/selection principles; separation of access/reading and hyperlink conventions are custom design; M04 §4.5, §4.6.3; limits on current material conversion reflect the review scope and custom design; M03 §3.1, §3.2.1–3.2.4 question-clarification principles; detailed separation rules are custom design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Propose scoped update research based on materials actually acquired; no new investigation, calculation or trial is performed now."
    }
  ]
}