{
  "schema_version": "chamgap-public-evidence-check-1.0",
  "public_id": "v2947-s1",
  "verdict_number": "2947",
  "title": "Reduced bathing/showering frequency × POEM improvement responders of at least 3 points at 4 weeks: evidence checklist",
  "view_version": "1.0",
  "view_created_date": "2026-10-11",
  "criteria_version": "1.0",
  "criteria_date": "2026-10-06",
  "review_date": null,
  "legacy_evidence_date": "2026-08-26",
  "review_scope": {
    "materials_read": "Existing review summaries and stored records of methodological application",
    "clinical_papers_directly_read": false,
    "new_clinical_search": false,
    "limitation": "The original content review remains incomplete. External abstracts, full texts, registrations, protocols, and SAPs remain unread, and access was not attempted. Separate content, screen, and link reviews were not performed at the time.",
    "date_meaning": "This is the date the stored materials were checked, not the date of a new search of the clinical literature."
  },
  "claim_context": {
    "population": "UK online recruitment; 438 people aged at least 1 year with POEM scores of at least 3; detailed population/respondent information unverified",
    "intervention": "Original study: baths/showers once or twice weekly for 4 weeks; actual exposure/adherence unverified",
    "dose": null,
    "comparator": "Active lifestyle comparator of at least six times weekly; both arms continued usual moisturizers/topical treatment",
    "endpoint": "Week-4 responders improving by at least 3 POEM points; adjusted risk difference/RR, distinct from mean/use days",
    "duration": "Week-4 responder time point kept separate from the mean of weekly measurements over 4 weeks",
    "excluded_extensions": [
      "Treating 3-point responders, mean POEM, the 2.2-point power assumption, and cream-use days as the same estimand, threshold, or hierarchy",
      "Elevating 2.2 points to a validated minimal clinically important difference or an importance threshold for responders/use days",
      "Calculating new RD/RR/CI/P/totals from original rates/events, doses/frequencies/amounts from use days, or hypothetical values",
      "Reusing allocation 438 (220/218), primary model 388 (193/195), responders 169/171, or safety 165/168/170 as the unverified cream-use denominator",
      "Using mean P=.30 as responder/cream P, or inheriting the general sensitivity narrative as review of all selected endpoints",
      "Converting reduced cream-use days into symptom/worsening/safety benefit or instructions to reduce/stop treatment",
      "Converting numerical directions of the two safety results or original unreported CI/P into significant worsening, causality, or safety certification",
      "Reusing pediatric crossover 42/40 participants, 2 weeks, different frequency/duration with immediate occlusive moisturization, or SCORAD as direct effects for the current frequency/POEM responder/cream question",
      "Converting pediatric evidence-list 2019/citation 2020 or review evidence-list 2020/citation 2021 year differences into new trials, added citations, or automatic corrections",
      "Summing the same people, arms, weeks, crossover periods, citations, review, related sheets, or 2887/2426 links as new independent trials/participants",
      "Converting registration “could not confirm”/“not applicable,” unreported support, historical public checks, or conflicts into current identity, absence, independence, or external-reading certification",
      "Inheriting parent D30, original axes, or cross-checks as subclaim D grades/C scores/axes or current content review",
      "Extending to optimal frequency, long-term/hot-humid/high-infection-risk settings, or effects/safety of other products/devices",
      "New evidence/reassessment or instructions on bathing/showering frequency, application/moisturization, treatment use, or treatment implementation"
    ]
  },
  "requirements": [
    {
      "item_id": "N01",
      "question_type": "Evidence condition",
      "question": "Which existing responder question and original verdict are preserved?",
      "needed": "Distinction between the selected subclaim, grade/note, and parent context",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Distinction between the selected subclaim, grade/note, and parent context.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Distinction between the selected subclaim, grade/note, and parent context. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M03 §3.1, §3.2.1–3.2.4 question-clarification principles; detailed separation rules are internally designed; M04 §4.5, §4.6.3; limits of this material conversion follow the review scope and internal design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Keep the question and verdict record separate when updating. This is a proposal; no new investigation, calculation, or trial was performed.",
      "current_reports": [
        "S01",
        "S02",
        "S03"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "The selected question is whether reducing bathing to once or twice weekly increases improvement of at least 3 POEM points. Its D grade and original RR/rate note are preserved. Parent D30 and axes are parent context.",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. The subclaim has no score/status/axis fields; parent values do not fill them. Mean POEM D and cream-use days C are other subclaims. The original content review remains incomplete.",
      "missingness": "The subclaim has no score/status/axis fields; parent values do not fill them. Mean POEM D and cream-use days C are other subclaims.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Correction records for the selected claim and parent assessment"
    },
    {
      "item_id": "N02",
      "question_type": "Evidence condition",
      "question": "Who is the actual population for the responder result?",
      "needed": "Age, diagnosis, baseline POEM, recruitment, and eligibility/exclusions",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Age, diagnosis, baseline POEM, recruitment, and eligibility/exclusions.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Age, diagnosis, baseline POEM, recruitment, and eligibility/exclusions. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M03 §3.2.1; detailed population conditions are Chamgap's own design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Connect the actual population scope with differences from other populations. This is a proposal; no new investigation, calculation, or trial was performed.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "The original manuscript describes a UK-wide online trial recruiting 438 people aged at least 1 year with POEM scores of at least 3.",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. Diagnostic criteria, age distribution, baseline severity, exclusions, and child respondent/proxy procedures are unverified. The original content review remains incomplete.",
      "missingness": "Diagnostic criteria, age distribution, baseline severity, exclusions, and child respondent/proxy procedures are unverified.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Recruitment/eligibility criteria and baseline/respondent characteristics"
    },
    {
      "item_id": "N03",
      "question_type": "Evidence condition",
      "question": "What were the study frequency and actual bath/shower exposure?",
      "needed": "Assigned frequency, actual frequency, baths/showers, adherence, and duration",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Assigned frequency, actual frequency, baths/showers, adherence, and duration.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Assigned frequency, actual frequency, baths/showers, adherence, and duration. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M03 §3.2.2–3.2.3; Reverse-direction labels and assessment adaptation are Chamgap design; M03 §3.2.3 and M08 §8.2.2–8.2.3; Chamgap application",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Distinguish nominal assignment from actual exposure. This is a proposal; no new investigation, calculation, or trial was performed.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "The historical study compared once or twice weekly with at least six times weekly over 4 weeks. This is not guidance on bathing or showering frequency.",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. Actual frequency, bath/shower proportions, water temperature/duration, and adherence/changes by arm are unverified. The original content review remains incomplete.",
      "missingness": "Actual frequency, bath/shower proportions, water temperature/duration, and adherence/changes by arm are unverified.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Exposure, adherence, and change records"
    },
    {
      "item_id": "N04",
      "question_type": "Evidence condition",
      "question": "What were the comparator and treatments common to both arms?",
      "needed": "Active lifestyle comparator, moisturizers, topical treatment, and arm differences",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Active lifestyle comparator, moisturizers, topical treatment, and arm differences.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Active lifestyle comparator, moisturizers, topical treatment, and arm differences. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M03 §3.2.2–3.2.3; Reverse-direction labels and assessment adaptation are Chamgap design; M03 §3.2.3 and M08 §8.2.2–8.2.3; Chamgap application",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Separate the contribution of lifestyle frequency from concomitant treatment. This is a proposal; no new investigation, calculation, or trial was performed.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "The comparator was an active lifestyle regimen of at least six times weekly. Both arms continued usual moisturizers and topical treatment.",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. Treatment identity, intensity, adherence, additional/rescue treatment, and changes by arm are unverified. No new effect of common treatment or instruction to change medication is created. The original content review remains incomplete.",
      "missingness": "Treatment identity, intensity, adherence, additional/rescue treatment, and changes by arm are unverified. No new effect of common treatment or instruction to change medication is created.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Common/changed treatments by arm and material on the effect of interest"
    },
    {
      "item_id": "N05",
      "question_type": "Evidence condition",
      "question": "What were the randomized design and allocation?",
      "needed": "Parallel groups, superiority, allocation/concealment, and baseline balance",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Parallel groups, superiority, allocation/concealment, and baseline balance.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Parallel groups, superiority, allocation/concealment, and baseline balance. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M08 §8.1–8.2.3; own application; M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; design-specific adaptation is our own design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Distinguish the design label from the verified scope of actual conduct. This is a proposal; no new investigation, calculation, or trial was performed.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "This was an online pragmatic parallel-group randomized superiority trial allocating 438 people as 220/218.",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. Allocation sequence, concealment, and detailed baseline balance by arm are unverified in this summary. The original content review remains incomplete.",
      "missingness": "Allocation sequence, concealment, and detailed baseline balance by arm are unverified in this summary.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Allocation methods and baseline characteristics"
    },
    {
      "item_id": "N06",
      "question_type": "Evidence condition",
      "question": "What were the limits of masking and responder measurement?",
      "needed": "Participants/assessors, respondents, and data-collection procedures",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Participants/assessors, respondents, and data-collection procedures.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Participants/assessors, respondents, and data-collection procedures. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M08 Table 8.2.a, M03 §3.2.4; internal application",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Record limits of symptom measurement and behavior change within the source scope. This is a proposal; no new investigation, calculation, or trial was performed.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "Participant masking was impossible given assigned bathing frequency. The original manuscript records that it did not count this as a separate defect.",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. Assessor/analyst masking, child proxy responses, and differences between weekly and week-4 collection are unverified. Impossibility alone does not create a new verdict of measurement failure. The original content review remains incomplete.",
      "missingness": "Assessor/analyst masking, child proxy responses, and differences between weekly and week-4 collection are unverified. Impossibility alone does not create a new verdict of measurement failure.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Masking and response-collection procedures"
    },
    {
      "item_id": "N07",
      "question_type": "Evidence condition",
      "question": "What outcomes are POEM and improvement of at least 3 points?",
      "needed": "Scale, direction, baseline-relative response definition, and time point",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Scale, direction, baseline-relative response definition, and time point.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Scale, direction, baseline-relative response definition, and time point. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M03 §3.2.4, M15 §15.3.1–15.3.3; outcome adaptation to each question is internally designed; M08 Table 8.2.a, M03 §3.2.4; internal application; M08 Table 8.2.a, M04 §4.6.3; internal application",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Keep the continuous mean and threshold response as different estimands. This is a proposal; no new investigation, calculation, or trial was performed.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "POEM has seven symptom items for the previous week, ranging from 0 to 28 points, with higher scores indicating worse symptoms. The selected result is the proportion improving by at least 3 points at 4 weeks.",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. Detailed rules for baseline-relative improvement, missing items, the responder analysis plan, and denominator selection are unverified. The original content review remains incomplete.",
      "missingness": "Detailed rules for baseline-relative improvement, missing items, the responder analysis plan, and denominator selection are unverified.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Response definition, scale collection, and analysis plan"
    },
    {
      "item_id": "N08",
      "question_type": "Evidence condition",
      "question": "Are the 3-point response threshold and 2.2-point power assumption the same?",
      "needed": "Threshold response definition, assumed mean difference, and clinical importance",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Threshold response definition, assumed mean difference, and clinical importance.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Threshold response definition, assumed mean difference, and clinical importance. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific result adaptation is our own design; M15 §15.3.1–15.3.3; own application; M08 Table 8.2.a, M04 §4.6.3; own application",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Record threshold response, mean effect, and power assumption separately. This is a proposal; no new investigation, calculation, or trial was performed.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "The responder threshold is improvement of at least 3 POEM points. The manuscript explicitly describes 2.2 points as the sample-size assumption for the primary mean result, rather than a validated minimal clinically important difference.",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. The basis/prespecification of the 3-point responder threshold and the importance of the responder result are unverified. The two thresholds do not replace one another. The original content review remains incomplete.",
      "missingness": "The basis/prespecification of the 3-point responder threshold and the importance of the responder result are unverified. The two thresholds do not replace one another.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original basis for the response threshold and sample-size/planning material"
    },
    {
      "item_id": "N09",
      "question_type": "Evidence condition",
      "question": "What were the original responder counts, denominators, and rates?",
      "needed": "Arm correspondence, responders/denominators, time point, and definition",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Arm correspondence, responders/denominators, time point, and definition.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Arm correspondence, responders/denominators, time point, and definition. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; design-specific adaptations are Chamgap's own design; M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are Chamgap's own design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Distinguish responder denominators from allocation/primary-model denominators. This is a proposal; no new investigation, calculation, or trial was performed.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "Original values for improvement of at least 3 points at 4 weeks are preserved: 97/169 (57.4%) in the once-or-twice-weekly arm versus 91/171 (53.2%) in the at-least-six-times-weekly arm.",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. Selection/attrition reasons for responder denominators, observation/imputation, and baseline correspondence by arm are unverified. No new total, difference, or rate is calculated. The original content review remains incomplete.",
      "missingness": "Selection/attrition reasons for responder denominators, observation/imputation, and baseline correspondence by arm are unverified. No new total, difference, or rate is calculated.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Week-4 responder flow/results table"
    },
    {
      "item_id": "N10",
      "question_type": "Evidence condition",
      "question": "What estimates are the adjusted risk difference and RR?",
      "needed": "Original RD/RR, intervals, adjusted model, and denominator",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Original RD/RR, intervals, adjusted model, and denominator.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Original RD/RR, intervals, adjusted model, and denominator. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M08 §8.2.2, M15 §15.3.1; Chamgap application; M15 §15.3.1–15.3.3; Chamgap application; M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; design-specific adaptations are Chamgap's own design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Keep original rates and adjusted estimands distinct. This is a proposal; no new investigation, calculation, or trial was performed.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "The adjusted risk difference of 3.5 percentage points (95% CI −6.6 to 13.6) and adjusted RR 1.06 (95% CI 0.89 to 1.28) are preserved.",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. Adjustment variables, model, actual included denominator, and responder P value are unverified. No new RD/RR/CI is calculated from the original rates. The original content review remains incomplete.",
      "missingness": "Adjustment variables, model, actual included denominator, and responder P value are unverified. No new RD/RR/CI is calculated from the original rates.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Adjusted responder analysis table and statistical analysis plan"
    },
    {
      "item_id": "N11",
      "question_type": "Evidence condition",
      "question": "What did the record say the nonsignificant responder result meant?",
      "needed": "Original null interpretation, interval of compatible effects, and importance",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Original null interpretation, interval of compatible effects, and importance.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Original null interpretation, interval of compatible effects, and importance. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M15 §15.3.1–15.3.3; Chamgap application; M04 §4.6.3, M15 §15.3.1–15.3.3; separation of statuses is Chamgap's own design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Keep observed intervals and the scope of the original conclusion separate. This is a proposal; no new investigation, calculation, or trial was performed.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "The selected note records the original rate/RR result as null. Its original intervals and D grade are preserved as history.",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. No new conclusion of exactly zero effect, equivalence, or exclusion of all important responder benefits is made. Criteria/plans for responder importance are unverified. The original content review remains incomplete.",
      "missingness": "No new conclusion of exactly zero effect, equivalence, or exclusion of all important responder benefits is made. Criteria/plans for responder importance are unverified.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Responder importance, hypotheses, and original conclusions"
    },
    {
      "item_id": "N12",
      "question_type": "Evidence condition",
      "question": "Is primary mean POEM being used as a responder value?",
      "needed": "Primary endpoint, continuous value/threshold response, time point, and denominator",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Primary endpoint, continuous value/threshold response, time point, and denominator.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Primary endpoint, continuous value/threshold response, time point, and denominator. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are Chamgap design; M08 Table 8.2.a, M04 §4.6.3; Chamgap adaptation; M04 §4.6.3, M15 §15.3.1–15.3.3; separation of statuses is Chamgap design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Record mean POEM, responders, and cream-use days separately. This is a proposal; no new investigation, calculation, or trial was performed.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "The primary outcome was the mean of weekly POEM measurements over 4 weeks. The adjusted difference −0.4 points (95% CI −1.3 to 0.4), P=.30, and exclusion of the assumed 2.2-point difference concern the mean result.",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. The mean P=.30, interval, power assumption, and 388-person model are not reused as responder results or denominators. The original content review remains incomplete.",
      "missingness": "The mean P=.30, interval, power assumption, and 388-person model are not reused as responder results or denominators.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Primary/secondary endpoint hierarchy and separate result tables"
    },
    {
      "item_id": "N13",
      "question_type": "Evidence condition",
      "question": "How do allocation, primary-model, and week-4 responder denominators differ?",
      "needed": "Allocation, follow-up responses, model, and endpoint-specific analysis denominators",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Allocation, follow-up responses, model, and endpoint-specific analysis denominators.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Allocation, follow-up responses, model, and endpoint-specific analysis denominators. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M08 Table 8.2.a, M15 §15.3 and M19 §19.1.2–19.2.4; Design-specific adaptation is Chamgap design; M08 §8.2.2 and M15 §15.3.1; Chamgap application",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Distinguish allocation from observed/model/responder analyses. This is a proposal; no new investigation, calculation, or trial was performed.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "Original denominators are preserved separately: 438 randomized as 220/218; the primary model of 388 people (193/195) with at least one follow-up POEM; and responders 169/171.",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. Exact correspondence between responder denominators and primary-model participants, plus missingness reasons/handling by arm, is unverified. No new missing-data count or rate is calculated. The original content review remains incomplete.",
      "missingness": "Exact correspondence between responder denominators and primary-model participants, plus missingness reasons/handling by arm, is unverified. No new missing-data count or rate is calculated.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Endpoint-specific flow diagrams and missingness/denominator tables"
    },
    {
      "item_id": "N14",
      "question_type": "Evidence condition",
      "question": "Which endpoint did allocation-based analysis and missing-data sensitivity concern?",
      "needed": "Analysis population, missingness assumptions, sensitivity results, and original scope",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Analysis population, missingness assumptions, sensitivity results, and original scope.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Analysis population, missingness assumptions, sensitivity results, and original scope. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M08 §8.2.2 and M15 §15.3.1: in-house application; M08 Table 8.2.a, M15 §15.3 and M19 §19.1.2–19.2.4: design-specific adaptation is in-house.",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Separate the original general narrative from the verified scope of the selected responder analysis. This is a proposal; no new investigation, calculation, or trial was performed.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "The original manuscript records the same conclusion from analysis by assigned allocation and missing-data sensitivity analyses.",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. Responder-specific models/values, ITT/PP definitions, and missingness assumptions are unverified. The general narrative is not treated as confirmation of every responder sensitivity analysis. The original content review remains incomplete.",
      "missingness": "Responder-specific models/values, ITT/PP definitions, and missingness assumptions are unverified. The general narrative is not treated as confirmation of every responder sensitivity analysis.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Analysis populations, statistical analysis plan, and endpoint-specific sensitivity results"
    },
    {
      "item_id": "N15",
      "question_type": "Evidence condition",
      "question": "Does the cream-use-day result demonstrate responder improvement?",
      "needed": "Separation of symptom response, treatment behavior, and secondary use days",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Separation of symptom response, treatment behavior, and secondary use days.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Separation of symptom response, treatment behavior, and secondary use days. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are Chamgap design; M04 §4.6.3, M15 §15.3.1–15.3.3; separation of statuses is Chamgap design; M03 §3.2.3, M08 §8.2.2–8.2.3; Chamgap adaptation",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Keep behavior endpoints and symptom response as different questions. This is a proposal; no new investigation, calculation, or trial was performed.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "Mean cream use of 0.5 fewer days per week (95% CI −0.8 to −0.1) in the once-or-twice-weekly arm was secondary. The manuscript did not elevate this to a symptom benefit.",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. The cream-use-day denominator/definition, intent, and linkage by responder are unverified. Reduced medication use is not converted into improved POEM response. The original content review remains incomplete.",
      "missingness": "The cream-use-day denominator/definition, intent, and linkage by responder are unverified. Reduced medication use is not converted into improved POEM response.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Cream-use days, responder linkage, and prespecified hierarchy"
    },
    {
      "item_id": "N16",
      "question_type": "Evidence condition",
      "question": "Were responder definitions/multiplicity verified in registration and plans?",
      "needed": "Registration, protocol, statistical analysis plan, primary/secondary hierarchy, and changes",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Registration, protocol, statistical analysis plan, primary/secondary hierarchy, and changes.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Registration, protocol, statistical analysis plan, primary/secondary hierarchy, and changes. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M08 Table 8.2.a, M04 §4.6.3; Chamgap application; M04 §4.5–4.6 principles for collecting and selecting materials; separation of access and reading and hyperlink rules are Chamgap's own design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Distinguish planned/changed endpoints, analyses, and time points. This is a proposal; no new investigation, calculation, or trial was performed.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "The original registration identifier is ISRCTN12016473. The summaries for the primary mean and week-4 responders are linked.",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. Original registration/planning documents, change histories, prespecified responder definitions, and multiple comparisons remain unread; access was not attempted. An identifier does not complete comparison with plans. The original content review remains incomplete.",
      "missingness": "Original registration/planning documents, change histories, prespecified responder definitions, and multiple comparisons remain unread; access was not attempted. An identifier does not complete comparison with plans.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Registration history, protocol, and SAP"
    },
    {
      "item_id": "N17",
      "question_type": "Evidence condition",
      "question": "What is the scope of funding and declared noninvolvement?",
      "needed": "NIHR programme/identifier, support, and role disclosures",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: NIHR programme/identifier, support, and role disclosures.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: NIHR programme/identifier, support, and role disclosures. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "Chamgap's own conditions for independence and attribution. The official methodological sections used in this example do not validate every detail of these items.",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Separate support sources, declared roles, and actual verification level. This is a proposal; no new investigation, calculation, or trial was performed.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "NIHR Programme Grants for Applied Research, NIHR203279, and the narrative of no role in design, collection, analysis, publication decisions, or writing are preserved.",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. Contracts, implementation, checking actual noninvolvement, and additional support are unverified. Public funding/declarations are not converted into certification of independence. The original content review remains incomplete.",
      "missingness": "Contracts, implementation, checking actual noninvolvement, and additional support are unverified. Public funding/declarations are not converted into certification of independence.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original funding and role disclosures"
    },
    {
      "item_id": "N18",
      "question_type": "Evidence condition",
      "question": "What is the scope of unreported product/device/placebo/commercial analysis support?",
      "needed": "Product/device/placebo supply, commercial analysis, and writing/publication support",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Product/device/placebo supply, commercial analysis, and writing/publication support.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Product/device/placebo supply, commercial analysis, and writing/publication support. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "Chamgap's own conditions for independence and attribution. The official methodological sections used in this example do not validate every detail of these items.",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Distinguish unreported and unverified from absent. This is a proposal; no new investigation, calculation, or trial was performed.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "The manuscript records that product/device/placebo supply and commercial analysis services were not reported.",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. Actual absence has not been newly verified. Individual employment/patents, writing/publication costs, and all support are unverified. The original content review remains incomplete.",
      "missingness": "Actual absence has not been newly verified. Individual employment/patents, writing/publication costs, and all support are unverified.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Support, author, analysis/writing/publication disclosures"
    },
    {
      "item_id": "N19",
      "question_type": "Evidence condition",
      "question": "What were the consultancy-fee and scale-development disclosures?",
      "needed": "Personal consultancy fees, POEM/RECAP development, conflicts, and actual roles",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Personal consultancy fees, POEM/RECAP development, conflicts, and actual roles.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Personal consultancy fees, POEM/RECAP development, conflicts, and actual roles. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "Chamgap independence and attribution conditions; the official methodology sections used in this example do not certify all these detailed items; M08 Table 8.2.a, M03 §3.2.4; Chamgap adaptation",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Record each disclosure separately from actual trial roles. This is a proposal; no new investigation, calculation, or trial was performed.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "The manuscript retained as conflicts E.J.M.’s personal fees from AbbVie, H.C.W.’s POEM development, and L.H./K.S.T.’s RECAP development disclosures.",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. Amounts, periods, contracts, measurement/analysis roles, and influence are unverified. Disclosures are not converted automatically into bias, result exclusion, or a new independence verdict. The original content review remains incomplete.",
      "missingness": "Amounts, periods, contracts, measurement/analysis roles, and influence are unverified. Disclosures are not converted automatically into bias, result exclusion, or a new independence verdict.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original personal conflict and scale/analysis role documents"
    },
    {
      "item_id": "N20",
      "question_type": "Evidence condition",
      "question": "Does the earlier pediatric crossover trial ask the same responder question?",
      "needed": "Population, crossover design, duration, different protocol, and SCORAD",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Population, crossover design, duration, different protocol, and SCORAD.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Population, crossover design, duration, different protocol, and SCORAD. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M04 §4.6.1–4.6.2; distinction between studies and reports; cohort and outcome connections are Chamgap adaptations; M03 §3.2.1; detailed population conditions are Chamgap design; M08 §8.1–8.2.3; Chamgap adaptation; M04 §4.6.1–4.6.2, M15 §15.3.1; Chamgap adaptation",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Do not sum the same children or repeated periods as independent trials/participants. This is a proposal; no new investigation, calculation, or trial was performed.",
      "current_reports": [
        "S02"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "The stored context describes Cardona’s randomized single-masked crossover trial in 42 children, 40 completers, 2 weeks, with SCORAD primary.",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. Age/baseline details, crossover sequence/washout, period-specific denominators, and POEM 3-point responders are unverified. It is not counted as direct replication of the same responder result. The original content review remains incomplete.",
      "missingness": "Age/baseline details, crossover sequence/washout, period-specific denominators, and POEM 3-point responders are unverified. It is not counted as direct replication of the same responder result.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Pediatric trial methods and period-specific result tables"
    },
    {
      "item_id": "N21",
      "question_type": "Evidence condition",
      "question": "What were the opposite direction and SCORAD values of the pediatric protocol?",
      "needed": "Differences in historical exposure, immediate occlusive moisturization, scale, and duration",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Differences in historical exposure, immediate occlusive moisturization, scale, and duration.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Differences in historical exposure, immediate occlusive moisturization, scale, and duration. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M03 §3.2.2–3.2.3; reverse-direction marker and test adaptations are Chamgap design; M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are Chamgap design; M04 §4.6.1–4.6.2, M15 §15.3.1; Chamgap adaptation; M04 §4.6.3, M15 §15.3.1–15.3.3; separation of statuses is Chamgap design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Preserve the opposite result from a different moisturization protocol and scale. This is a proposal; no new investigation, calculation, or trial was performed.",
      "current_reports": [
        "S02"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "The historical pediatric study compared twice-daily 15–20-minute soak-and-seal with immediate occlusive moisturization against twice-weekly bathing for at most 10 minutes. The original 21.2-point greater SCORAD reduction (95% CI 14.9 to 27.6), P<.0001, belongs only to that comparison.",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. This is not the same frequency-only comparison as the current online trial and is not converted into POEM points or response rates. No implementation instructions are created. The original content review remains incomplete.",
      "missingness": "This is not the same frequency-only comparison as the current online trial and is not converted into POEM points or response rates. No implementation instructions are created.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Exposure/moisturization, scale, and crossover analysis material"
    },
    {
      "item_id": "N22",
      "question_type": "Evidence condition",
      "question": "How are the pediatric report’s years, registration, and support preserved?",
      "needed": "Report identity, evidence-list/citation years, registration records, and funding",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Report identity, evidence-list/citation years, registration records, and funding.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Report identity, evidence-list/citation years, registration records, and funding. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M04 §4.6.1–4.6.2; distinction between studies and reports; cohort and outcome connections are Chamgap adaptations; M04 §4.5, §4.6.3; limitations of this conversion follow the review scope and Chamgap design; Chamgap independence and attribution conditions; the official methodology sections used in this example do not certify all these detailed items; M08 Table 8.2.a, M04 §4.6.3; Chamgap adaptation",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Separate year wording, trial identity, and actual verification level. This is a proposal; no new investigation, calculation, or trial was performed.",
      "current_reports": [
        "S02"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "The evidence list gives Cardona 2019; the citation gives the 2020 issue and 2019 DOI wording. The original registration field “could not confirm” and historical abstract classification “Research Support, Non-U.S. Gov't” are preserved.",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. Publication stages underlying the year difference, actual supporting institution/conflicts, and registration are unverified. These are not turned into a new paper/independent trial or an actual registration identifier. The original content review remains incomplete.",
      "missingness": "Publication stages underlying the year difference, actual supporting institution/conflicts, and registration are unverified. These are not turned into a new paper/independent trial or an actual registration identifier.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original bibliographic/publication history and registration/support material"
    },
    {
      "item_id": "N23",
      "question_type": "Evidence condition",
      "question": "Does the review directly answer the same 3-point responder question?",
      "needed": "Included protocols, endpoints, heterogeneity, populations, and designs",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Included protocols, endpoints, heterogeneity, populations, and designs.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Included protocols, endpoints, heterogeneity, populations, and designs. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M04 §4.6.1–4.6.2; distinction between studies and reports; cohort and outcome connections are Chamgap adaptations; M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are Chamgap design; M04 §4.6.1–4.6.2, M15 §15.3.1; Chamgap adaptation; M04 §4.6.3, M15 §15.3.1–15.3.3; separation of statuses is Chamgap design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Distinguish synthesis context from different protocols from the original responder question. This is a proposal; no new investigation, calculation, or trial was performed.",
      "current_reports": [
        "S03"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "Hua’s review synthesized bathing/showering frequency and eczema severity from 13 prospective studies. Its original conclusion was that daily washing was not associated with worse severity, but studies were few and heterogeneous and the optimal frequency was unclear.",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. Direct analysis of the selected POEM 3-point responders/current comparison, trial-specific/population-specific results, and overlap are unverified. The review is not counted as new direct replication. The original content review remains incomplete.",
      "missingness": "Direct analysis of the selected POEM 3-point responders/current comparison, trial-specific/population-specific results, and overlap are unverified. The review is not counted as new direct replication.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Included studies and protocol/endpoint-specific result tables"
    },
    {
      "item_id": "N24",
      "question_type": "Evidence condition",
      "question": "What are the review’s year, registration, and funding statements?",
      "needed": "Citation/evidence-list years, support/plans, and historical access scope",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Citation/evidence-list years, support/plans, and historical access scope.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Citation/evidence-list years, support/plans, and historical access scope. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M04 §4.5, §4.6.3; limitations of this conversion follow the review scope and Chamgap design; Chamgap independence and attribution conditions; the official methodology sections used in this example do not certify all these detailed items; M08 Table 8.2.a, M04 §4.6.3; Chamgap adaptation; M04 §4.5–4.6; material collection/selection principles; access/reading separation and hyperlink contract are Chamgap design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Distinguish original years, identity, and access history from new material. This is a proposal; no new investigation, calculation, or trial was performed.",
      "current_reports": [
        "S03"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "The evidence list/manuscript describes the 2020 review; the citation gives the 2021 issue and 2020 DOI. The original registration field “not applicable” and historical statement that specific funding could not be established are preserved.",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. Differences in publication stage, actual funding/conflicts, and plans/registration have not been externally verified in this work. Not applicable is not used to certify absence of registration. The original content review remains incomplete.",
      "missingness": "Differences in publication stage, actual funding/conflicts, and plans/registration have not been externally verified in this work. Not applicable is not used to certify absence of registration.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Bibliographic/publication history and review plans/disclosures"
    },
    {
      "item_id": "N25",
      "question_type": "Harm-information gaps supplementing the efficacy table",
      "question": "What are the original rates/denominators for the two safety outcomes?",
      "needed": "Treatment changes for worsening, medical advice, people/denominators, and time point",
      "role": "Supplementary",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Treatment changes for worsening, medical advice, people/denominators, and time point.",
      "application_exception": "Addresses safety-material gaps for the selected subclaim. POEM, cream-use days, or parent safety wording do not establish safety or generate new harm incidence or instructions on bathing frequency/treatment behavior.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Treatment changes for worsening, medical advice, people/denominators, and time point. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M19 §19.1.2–19.2.4; Chamgap adaptation; M19 §19.1.2–19.2.4; detailed distinctions are Chamgap design; M19 §19.1.2–19.2.4; Chamgap adaptation; M19 §19.1.2–19.2.4, M04 §4.6.3; Chamgap adaptation",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Distinguish each outcome’s units from POEM responder units. This is a proposal; no new investigation, calculation, or trial was performed.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "Treatment changes for worsening, 17/165 (10.3%) versus 13/168 (7.7%), and medical advice, 20/165 (12.1%) versus 13/170 (7.6%), are preserved separately. The original narrative describes both as numerically higher in the less-frequent-washing arm.",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. These differ from responder denominators 169/171 and primary-model denominators 193/195. Event definitions/exact periods, overlap, and missingness are unverified; no new incidence or total is calculated. The original content review remains incomplete.",
      "missingness": "These differ from responder denominators 169/171 and primary-model denominators 193/195. Event definitions/exact periods, overlap, and missingness are unverified; no new incidence or total is calculated.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Outcome-specific safety/behavior definitions and denominator tables"
    },
    {
      "item_id": "N26",
      "question_type": "Harm-information gaps supplementing the efficacy table",
      "question": "Do numerical safety differences establish significant worsening or causality?",
      "needed": "Original unreported CI/P wording, collection, concomitant treatment, and verdict scope",
      "role": "Supplementary",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Original unreported CI/P wording, collection, concomitant treatment, and verdict scope.",
      "application_exception": "Addresses safety-material gaps for the selected subclaim. POEM, cream-use days, or parent safety wording do not establish safety or generate new harm incidence or instructions on bathing frequency/treatment behavior.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Original unreported CI/P wording, collection, concomitant treatment, and verdict scope. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M19 §19.1.2–19.2.4; Chamgap adaptation; M19 §19.2.2–19.2.4, M03 §3.2.3; Chamgap adaptation; M19 §19.2.2–19.2.4; design considerations; detailed confounding records are Chamgap design; Chamgap interpretation boundary; M19 is a reference principle, not execution of an official causality tool",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Separate actual levels of behavior/worsening records, testing, and causality. This is a proposal; no new investigation, calculation, or trial was performed.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "The manuscript records that significant worsening cannot be concluded because between-arm CI/P values for the two safety outcomes were not reported.",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. The complete external full text was not read in this work. Numerical direction is not converted into significant worsening, causality, or absence of all safety concerns, and no new CI/P is calculated. The original content review remains incomplete.",
      "missingness": "The complete external full text was not read in this work. Numerical direction is not converted into significant worsening, causality, or absence of all safety concerns, and no new CI/P is calculated.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Safety analysis, collection, and concomitant treatment material"
    },
    {
      "item_id": "N27",
      "question_type": "Evidence condition",
      "question": "How are reports, crossover periods, and related sheets shared?",
      "needed": "Citation-to-trial/review-to-result linkage and repeated/included relationships",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Citation-to-trial/review-to-result linkage and repeated/included relationships.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Citation-to-trial/review-to-result linkage and repeated/included relationships. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "Study/report distinction in M04 §4.6.1–4.6.2; Cohort/outcome linkage is Chamgap application; M04 §4.6.1–4.6.2 and M15 §15.3.1; Chamgap application",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Distinguish unrecorded unique clinical totals from report entries. This is a proposal; no new investigation, calculation, or trial was performed.",
      "current_reports": [
        "S01",
        "S02",
        "S03"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "The online trial, pediatric crossover trial, and review are distinguished by report. The existing two selected sheets share the same stored summary and direct trial. The pediatric 42/40 participants, crossover periods, and 13-study review do not constitute a new total of independent participants.",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. Included/related reports and identity overlap in the review have not been externally compared. Original R0/I2 are not used as new replication/independence certification. The original content review remains incomplete.",
      "missingness": "Included/related reports and identity overlap in the review have not been externally compared. Original R0/I2 are not used as new replication/independence certification.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Included/related report tables and registration linkage"
    },
    {
      "item_id": "N28",
      "question_type": "Harm-information gaps supplementing the efficacy table",
      "question": "Are related manuscript links and other products/long-term scopes combined?",
      "needed": "Selected frequency/4-week response, separate manuscripts, climates, and risk groups",
      "role": "Supplementary",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Selected frequency/4-week response, separate manuscripts, climates, and risk groups.",
      "application_exception": "Addresses safety-material gaps for the selected subclaim. POEM, cream-use days, or parent safety wording do not establish safety or generate new harm incidence or instructions on bathing frequency/treatment behavior.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Selected frequency/4-week response, separate manuscripts, climates, and risk groups. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M03 §3.2.1–3.2.4; dose, duration and effect-modification details are Chamgap design; M03 §3.2.4; Chamgap extrapolation boundary; M19 §19.1.2–19.2.4; Chamgap adaptation; M19 §19.1.2–19.2.4; Chamgap adaptation",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Separate other products, environments, and durations from the selected question. This is a proposal; no new investigation, calculation, or trial was performed.",
      "current_reports": [
        "S01",
        "S02",
        "S03"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "Stored links to bath additives 2887 and water softeners 2426 are separate original verdicts and are not additional trials for this question. The manuscript did not generalize beyond 4 weeks, to hot/humid environments, or to people at high infection risk.",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. Direct material for related manuscripts, long-term outcomes, other environments, and risk groups was not retrieved in this work. No optimal-frequency or treatment-behavior guidance is created. The original content review remains incomplete.",
      "missingness": "Direct material for related manuscripts, long-term outcomes, other environments, and risk groups was not retrieved in this work. No optimal-frequency or treatment-behavior guidance is created.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Material on separate exposures/populations and long-term outcomes"
    },
    {
      "item_id": "N29",
      "question_type": "Evidence condition",
      "question": "What is the scope of original verdicts, dates, languages, empty values, and corrections?",
      "needed": "D30, axes/safety, bilingual manuscript, and historical cross-checks/corrections",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: D30, axes/safety, bilingual manuscript, and historical cross-checks/corrections.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: D30, axes/safety, bilingual manuscript, and historical cross-checks/corrections. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M04 §4.5, §4.6.3; current material-conversion limits reflect review scope and our own design; M04 §4.6.3, M15 §15.3.1–15.3.3; status distinctions are our own design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Separate original records from production and correction events. This is a proposal; no new investigation, calculation, or trial was performed.",
      "current_reports": [
        "S01",
        "S02",
        "S03"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "D30, original axis C0, false flags and empty grade-override reasons, the bilingual manuscript, 2026-08-26, the empty correction array and empty deliberation string, historical cross-checks, original wording, and bibliographic year differences are preserved in the complete stored summary.",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. Manuscript wording/typos and year differences are not automatically corrected. This is not a new current search, original-paper review, original-language comparison, or correction check. The original content review remains incomplete.",
      "missingness": "Manuscript wording/typos and year differences are not automatically corrected. This is not a new current search, original-paper review, original-language comparison, or correction check.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "New correction records and user feedback"
    },
    {
      "item_id": "N30",
      "question_type": "Evidence condition",
      "question": "What is the reading level of summaries and external original material?",
      "needed": "Original URLs and status of summaries/papers, registration, protocols, statistical analysis plans, and disclosures",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Original URLs and status of summaries/papers, registration, protocols, statistical analysis plans, and disclosures.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Original URLs and status of summaries/papers, registration, protocols, statistical analysis plans, and disclosures. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M04 §4.5–4.6 material collection/selection principles; acquisition/reading separation and hyperlink specifications are internally designed; M04 §4.5, §4.6.3; limits of this material conversion follow the review scope and internal design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Distinguish existence, acquisition, actual reading, and access history. This is a proposal; no new investigation, calculation, or trial was performed.",
      "current_reports": [
        "S01",
        "S02",
        "S03"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "The complete stored summary and 3 evidence entries/3 citations were read for production and original source links connected. Summaries are marked “summary read” and external material “unread.”",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. External abstracts/full texts, registration/plans, and disclosures remain unread; access was not attempted. Historical public-verification wording is not inherited as access/review in this work. The original content review remains incomplete.",
      "missingness": "External abstracts/full texts, registration/plans, and disclosures remain unread; access was not attempted. Historical public-verification wording is not inherited as access/review in this work.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original material and actual reading history for each material"
    }
  ],
  "reports": [
    {
      "report_id": "S01",
      "title": "Bradshaw L et al. 2026 Eczema Bathing Study",
      "url": "https://pubmed.ncbi.nlm.nih.gov/41208015/",
      "report_type": "UK-wide online pragmatic parallel-group randomized superiority trial",
      "existence": "Stored bibliography exists; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "study_family": "RG2947-ECZEMA-BATHING",
      "independent_replication": null,
      "observed_result": "Original responder values are preserved: 97/169 (57.4%) versus 91/171 (53.2%); adjusted risk difference 3.5 percentage points (95% CI −6.6 to 13.6); adjusted RR 1.06 (95% CI 0.89 to 1.28). The subclaim D grade and original null note are historical verdicts, rather than new certification of exactly zero effect, equivalence, or exclusion of all important benefit. Original primary mean −0.4 points (95% CI −1.3 to 0.4), P=0.30, the 2.2-point power assumption, and the 388-person model are separate context and are not used as responder P values or denominators.",
      "result_level": "Outcome wording in the stored summary",
      "source_evidence_date": "2026-08-26",
      "materials": [
        {
          "material_type": "Stored summary",
          "public_status": "Stored file",
          "access_status": "Stored summary",
          "acquired": true,
          "actually_read": "Summary read",
          "as_of": "2026-08-26",
          "qualification": "Only stored-summary and bibliographic content was used for production. External material verification/review is not complete."
        },
        {
          "material_type": "External paper",
          "public_status": "Public availability unverified; only bibliography links preserved",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-08-26",
          "qualification": "No external access or click testing was performed in the original preparation. URLs or registration identifiers alone do not upgrade acquisition/reading status."
        },
        {
          "material_type": "Registration material",
          "public_status": "Public availability unverified; only bibliography links preserved",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-08-26",
          "qualification": "No external access or click testing was performed in the original preparation. URLs or registration identifiers alone do not upgrade acquisition/reading status."
        },
        {
          "material_type": "Protocol",
          "public_status": "Public availability unverified; only bibliography links preserved",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-08-26",
          "qualification": "No external access or click testing was performed in the original preparation. URLs or registration identifiers alone do not upgrade acquisition/reading status."
        },
        {
          "material_type": "Statistical analysis plan",
          "public_status": "Public availability unverified; only bibliography links preserved",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-08-26",
          "qualification": "No external access or click testing was performed in the original preparation. URLs or registration identifiers alone do not upgrade acquisition/reading status."
        },
        {
          "material_type": "Funding, product-support and COI material",
          "public_status": "Public availability unverified; only bibliography links preserved",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-08-26",
          "qualification": "No external access or click testing was performed in the original preparation. URLs or registration identifiers alone do not upgrade acquisition/reading status."
        }
      ],
      "links": [
        {
          "label": "PubMed",
          "url": "https://pubmed.ncbi.nlm.nih.gov/41208015/"
        }
      ]
    },
    {
      "report_id": "S02",
      "title": "Cardona ID et al. 2019 pediatric soak-and-seal trial",
      "url": "https://pubmed.ncbi.nlm.nih.gov/31733336/",
      "report_type": "Pediatric randomized single-masked crossover trial",
      "existence": "Stored bibliography exists; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "study_family": "RG2947-CARDONA-PEDIATRIC-CROSSOVER",
      "independent_replication": null,
      "observed_result": "In the historical study, twice-daily 15–20-minute soak-and-seal produced a 21.2-point greater SCORAD reduction than twice-weekly bathing for at most 10 minutes (95% CI 14.9 to 27.6), P<0.0001. These values belong to a different protocol/scale and are not converted into POEM points, response rates, or cream-use days. Unverified registration, abstract support classification with supporting institution unestablished, and evidence-list/citation year differences are preserved and not backdated as external verification in this work.",
      "result_level": "Outcome wording in the stored summary",
      "source_evidence_date": "2026-08-26",
      "materials": [
        {
          "material_type": "Stored summary",
          "public_status": "Stored file",
          "access_status": "Stored summary",
          "acquired": true,
          "actually_read": "Summary read",
          "as_of": "2026-08-26",
          "qualification": "Only stored-summary and bibliographic content was used for production. External material verification/review is not complete."
        },
        {
          "material_type": "External paper",
          "public_status": "Public availability unverified; only bibliography links preserved",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-08-26",
          "qualification": "No external access or click testing was performed in the original preparation. URLs or registration identifiers alone do not upgrade acquisition/reading status."
        },
        {
          "material_type": "Registration material",
          "public_status": "Public availability unverified; only bibliography links preserved",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-08-26",
          "qualification": "No external access or click testing was performed in the original preparation. URLs or registration identifiers alone do not upgrade acquisition/reading status."
        },
        {
          "material_type": "Protocol",
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      "title": "Hua T et al. 2020 systematic review and meta-analysis",
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      "result_level": "Outcome wording in the stored summary",
      "source_evidence_date": "2026-08-26",
      "materials": [
        {
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        },
        {
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        {
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      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
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      "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13",
      "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.",
      "review_level": "Preserved method HTML copies; no current method-content re-review or official tool execution"
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      "id": "M04",
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      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04",
      "section": "§4.5, §4.6.1–4.6.3, MECIR C42",
      "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.",
      "review_level": "Preserved method HTML copies; no current method-content re-review or official tool execution"
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      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08",
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      "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.",
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      "section": "§15.2.4, §15.3.1–15.3.3",
      "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.",
      "review_level": "Preserved method HTML copies; no current method-content re-review or official tool execution"
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    {
      "id": "M19",
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      "section": "§19.1.2, §19.2.1–19.2.4",
      "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.",
      "review_level": "Preserved method HTML copies; no current method-content re-review or official tool execution"
    }
  ],
  "status_dictionary": {
    "Met": "Status for necessary evidence confirmed after existing content review. No completion is declared in the current presentation.",
    "Partly verified": "Some information in the stored summary is linked into the table. External comparison/content review is not complete.",
    "Unverified": "The article leaves this unverified, or required material is absent from the current stored summary. This is distinct from zero, absence or safety.",
    "Review incomplete": "Existing content review remains incomplete.",
    "Not reported": "Not reported within the stored material actually read; not extended to the entire primary paper.",
    "Inaccessible": "Means an actual access failure. Access not attempted here is not assigned this state.",
    "Not applicable": "Not used as a substitute for an evidence gap.",
    "Conflicting data": "Requires an observed disagreement under the same comparison criteria; not automatically judged in this production.",
    "Insufficient evidence for the conditions": "Marks a gap in additional material required by the selected conditions; not a new efficacy grade."
  },
  "study_overlap": {
    "state": "Unverified",
    "unique_trial_count": null,
    "unique_participant_count": null,
    "reason": "The UK online Eczema Bathing Study and ISRCTN12016473 describe a parallel-group superiority trial of 438 people (220/218), aged at least 1 year with POEM scores of at least 3, comparing once or twice weekly with at least six times weekly for 4 weeks. Both arms continued usual moisturizers/topical treatment, participant masking was impossible, and the primary model contained 388 people (193/195). Week-4 responders 169/171, the unverified cream-use-day denominator, and safety-specific denominators 165/168/170 are distinct. The same trial, reports, participants, arms, weeks, and selected sheets sharing the same material are not summed as independent trials/participants. Report/material entries are not totals of unique clinical trials, participants, or independent replications; unique totals remain unrecorded. Cardona’s pediatric single-masked crossover trial preserves the evidence-list year 2019 separately from the citation’s 2020 issue and 2019 DOI. Its 42 allocated participants, 40 completers, 2 weeks, primary SCORAD, and combined bathing frequency/duration with immediate moisturization describe a different protocol. It is not direct replication of the current comparison, POEM responders, or cream-use days. Crossover periods, sequence, washout, publication stage, funding, and registration details are unverified. Selected sheets sharing material and report/material entries are not summed as unique trials, participants, or independent replications; unique totals remain unrecorded. Hua’s synthesis of 13 prospective studies preserves evidence-list/manuscript 2020 separately from citation issue 2021 and DOI 2020. Its original conclusion of few, heterogeneous protocols, eczema severity, and unclear optimal frequency is retained. Included/related trial overlap, population/endpoint denominators, and publication stages remain unverified; it is not counted as independent RCT, responder, or cream-use-day replication. Selected sheets sharing material and report/material entries are not summed as unique trials, participants, or independent replications; unique totals remain unrecorded."
  },
  "history": [
    {
      "date": "2026-10-11",
      "kind": "Separation of public-facing pages and materials",
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      "change": "The public page and data were prepared from the existing 30 items. No new clinical search, verification-status change or scoring was performed."
    }
  ],
  "language": "en",
  "translation_date": "2026-10-11"
}