{
  "schema_version": "chamgap-public-criteria-1.0",
  "title": "Reduced bathing/showering frequency × POEM improvement responders of at least 3 points at 4 weeks: evidence checklist",
  "language": "en",
  "translation_date": "2026-10-11",
  "criteria_version": "1.0",
  "criteria_date": "2026-10-06",
  "condition_origin": "Chamgap's own application conditions",
  "method_sources": [
    {
      "id": "M03",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03",
      "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13",
      "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.",
      "review_level": "Preserved method HTML copies; no current method-content re-review or official tool execution"
    },
    {
      "id": "M04",
      "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04",
      "section": "§4.5, §4.6.1–4.6.3, MECIR C42",
      "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.",
      "review_level": "Preserved method HTML copies; no current method-content re-review or official tool execution"
    },
    {
      "id": "M08",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08",
      "section": "§8.1–8.2.3, Table 8.2.a",
      "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.",
      "review_level": "Preserved method HTML copies; no current method-content re-review or official tool execution"
    },
    {
      "id": "M15",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15",
      "section": "§15.2.4, §15.3.1–15.3.3",
      "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.",
      "review_level": "Preserved method HTML copies; no current method-content re-review or official tool execution"
    },
    {
      "id": "M19",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19",
      "section": "§19.1.2, §19.2.1–19.2.4",
      "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.",
      "review_level": "Preserved method HTML copies; no current method-content re-review or official tool execution"
    }
  ],
  "status_dictionary": {
    "Met": "Status for necessary evidence confirmed after existing content review. No completion is declared in the current presentation.",
    "Partly verified": "Some information in the stored summary is linked into the table. External comparison/content review is not complete.",
    "Unverified": "The article leaves this unverified, or required material is absent from the current stored summary. This is distinct from zero, absence or safety.",
    "Review incomplete": "Existing content review remains incomplete.",
    "Not reported": "Not reported within the stored material actually read; not extended to the entire primary paper.",
    "Inaccessible": "Means an actual access failure. Access not attempted here is not assigned this state.",
    "Not applicable": "Not used as a substitute for an evidence gap.",
    "Conflicting data": "Requires an observed disagreement under the same comparison criteria; not automatically judged in this production.",
    "Insufficient evidence for the conditions": "Marks a gap in additional material required by the selected conditions; not a new efficacy grade."
  },
  "requirements": [
    {
      "item_id": "N01",
      "question_type": "Evidence condition",
      "question": "Which existing responder question and original verdict are preserved?",
      "needed": "Distinction between the selected subclaim, grade/note, and parent context",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Distinction between the selected subclaim, grade/note, and parent context.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Distinction between the selected subclaim, grade/note, and parent context. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M03 §3.1, §3.2.1–3.2.4 question-clarification principles; detailed separation rules are internally designed; M04 §4.5, §4.6.3; limits of this material conversion follow the review scope and internal design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Keep the question and verdict record separate when updating. This is a proposal; no new investigation, calculation, or trial was performed."
    },
    {
      "item_id": "N02",
      "question_type": "Evidence condition",
      "question": "Who is the actual population for the responder result?",
      "needed": "Age, diagnosis, baseline POEM, recruitment, and eligibility/exclusions",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Age, diagnosis, baseline POEM, recruitment, and eligibility/exclusions.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Age, diagnosis, baseline POEM, recruitment, and eligibility/exclusions. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M03 §3.2.1; detailed population conditions are Chamgap's own design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Connect the actual population scope with differences from other populations. This is a proposal; no new investigation, calculation, or trial was performed."
    },
    {
      "item_id": "N03",
      "question_type": "Evidence condition",
      "question": "What were the study frequency and actual bath/shower exposure?",
      "needed": "Assigned frequency, actual frequency, baths/showers, adherence, and duration",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Assigned frequency, actual frequency, baths/showers, adherence, and duration.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Assigned frequency, actual frequency, baths/showers, adherence, and duration. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M03 §3.2.2–3.2.3; Reverse-direction labels and assessment adaptation are Chamgap design; M03 §3.2.3 and M08 §8.2.2–8.2.3; Chamgap application",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Distinguish nominal assignment from actual exposure. This is a proposal; no new investigation, calculation, or trial was performed."
    },
    {
      "item_id": "N04",
      "question_type": "Evidence condition",
      "question": "What were the comparator and treatments common to both arms?",
      "needed": "Active lifestyle comparator, moisturizers, topical treatment, and arm differences",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Active lifestyle comparator, moisturizers, topical treatment, and arm differences.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Active lifestyle comparator, moisturizers, topical treatment, and arm differences. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M03 §3.2.2–3.2.3; Reverse-direction labels and assessment adaptation are Chamgap design; M03 §3.2.3 and M08 §8.2.2–8.2.3; Chamgap application",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Separate the contribution of lifestyle frequency from concomitant treatment. This is a proposal; no new investigation, calculation, or trial was performed."
    },
    {
      "item_id": "N05",
      "question_type": "Evidence condition",
      "question": "What were the randomized design and allocation?",
      "needed": "Parallel groups, superiority, allocation/concealment, and baseline balance",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Parallel groups, superiority, allocation/concealment, and baseline balance.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Parallel groups, superiority, allocation/concealment, and baseline balance. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M08 §8.1–8.2.3; own application; M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; design-specific adaptation is our own design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Distinguish the design label from the verified scope of actual conduct. This is a proposal; no new investigation, calculation, or trial was performed."
    },
    {
      "item_id": "N06",
      "question_type": "Evidence condition",
      "question": "What were the limits of masking and responder measurement?",
      "needed": "Participants/assessors, respondents, and data-collection procedures",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Participants/assessors, respondents, and data-collection procedures.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Participants/assessors, respondents, and data-collection procedures. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M08 Table 8.2.a, M03 §3.2.4; internal application",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Record limits of symptom measurement and behavior change within the source scope. This is a proposal; no new investigation, calculation, or trial was performed."
    },
    {
      "item_id": "N07",
      "question_type": "Evidence condition",
      "question": "What outcomes are POEM and improvement of at least 3 points?",
      "needed": "Scale, direction, baseline-relative response definition, and time point",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Scale, direction, baseline-relative response definition, and time point.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Scale, direction, baseline-relative response definition, and time point. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M03 §3.2.4, M15 §15.3.1–15.3.3; outcome adaptation to each question is internally designed; M08 Table 8.2.a, M03 §3.2.4; internal application; M08 Table 8.2.a, M04 §4.6.3; internal application",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Keep the continuous mean and threshold response as different estimands. This is a proposal; no new investigation, calculation, or trial was performed."
    },
    {
      "item_id": "N08",
      "question_type": "Evidence condition",
      "question": "Are the 3-point response threshold and 2.2-point power assumption the same?",
      "needed": "Threshold response definition, assumed mean difference, and clinical importance",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Threshold response definition, assumed mean difference, and clinical importance.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Threshold response definition, assumed mean difference, and clinical importance. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific result adaptation is our own design; M15 §15.3.1–15.3.3; own application; M08 Table 8.2.a, M04 §4.6.3; own application",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Record threshold response, mean effect, and power assumption separately. This is a proposal; no new investigation, calculation, or trial was performed."
    },
    {
      "item_id": "N09",
      "question_type": "Evidence condition",
      "question": "What were the original responder counts, denominators, and rates?",
      "needed": "Arm correspondence, responders/denominators, time point, and definition",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Arm correspondence, responders/denominators, time point, and definition.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Arm correspondence, responders/denominators, time point, and definition. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; design-specific adaptations are Chamgap's own design; M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are Chamgap's own design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Distinguish responder denominators from allocation/primary-model denominators. This is a proposal; no new investigation, calculation, or trial was performed."
    },
    {
      "item_id": "N10",
      "question_type": "Evidence condition",
      "question": "What estimates are the adjusted risk difference and RR?",
      "needed": "Original RD/RR, intervals, adjusted model, and denominator",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Original RD/RR, intervals, adjusted model, and denominator.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Original RD/RR, intervals, adjusted model, and denominator. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M08 §8.2.2, M15 §15.3.1; Chamgap application; M15 §15.3.1–15.3.3; Chamgap application; M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; design-specific adaptations are Chamgap's own design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Keep original rates and adjusted estimands distinct. This is a proposal; no new investigation, calculation, or trial was performed."
    },
    {
      "item_id": "N11",
      "question_type": "Evidence condition",
      "question": "What did the record say the nonsignificant responder result meant?",
      "needed": "Original null interpretation, interval of compatible effects, and importance",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Original null interpretation, interval of compatible effects, and importance.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Original null interpretation, interval of compatible effects, and importance. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M15 §15.3.1–15.3.3; Chamgap application; M04 §4.6.3, M15 §15.3.1–15.3.3; separation of statuses is Chamgap's own design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Keep observed intervals and the scope of the original conclusion separate. This is a proposal; no new investigation, calculation, or trial was performed."
    },
    {
      "item_id": "N12",
      "question_type": "Evidence condition",
      "question": "Is primary mean POEM being used as a responder value?",
      "needed": "Primary endpoint, continuous value/threshold response, time point, and denominator",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Primary endpoint, continuous value/threshold response, time point, and denominator.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Primary endpoint, continuous value/threshold response, time point, and denominator. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are Chamgap design; M08 Table 8.2.a, M04 §4.6.3; Chamgap adaptation; M04 §4.6.3, M15 §15.3.1–15.3.3; separation of statuses is Chamgap design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Record mean POEM, responders, and cream-use days separately. This is a proposal; no new investigation, calculation, or trial was performed."
    },
    {
      "item_id": "N13",
      "question_type": "Evidence condition",
      "question": "How do allocation, primary-model, and week-4 responder denominators differ?",
      "needed": "Allocation, follow-up responses, model, and endpoint-specific analysis denominators",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Allocation, follow-up responses, model, and endpoint-specific analysis denominators.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Allocation, follow-up responses, model, and endpoint-specific analysis denominators. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M08 Table 8.2.a, M15 §15.3 and M19 §19.1.2–19.2.4; Design-specific adaptation is Chamgap design; M08 §8.2.2 and M15 §15.3.1; Chamgap application",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Distinguish allocation from observed/model/responder analyses. This is a proposal; no new investigation, calculation, or trial was performed."
    },
    {
      "item_id": "N14",
      "question_type": "Evidence condition",
      "question": "Which endpoint did allocation-based analysis and missing-data sensitivity concern?",
      "needed": "Analysis population, missingness assumptions, sensitivity results, and original scope",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Analysis population, missingness assumptions, sensitivity results, and original scope.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Analysis population, missingness assumptions, sensitivity results, and original scope. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M08 §8.2.2 and M15 §15.3.1: in-house application; M08 Table 8.2.a, M15 §15.3 and M19 §19.1.2–19.2.4: design-specific adaptation is in-house.",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Separate the original general narrative from the verified scope of the selected responder analysis. This is a proposal; no new investigation, calculation, or trial was performed."
    },
    {
      "item_id": "N15",
      "question_type": "Evidence condition",
      "question": "Does the cream-use-day result demonstrate responder improvement?",
      "needed": "Separation of symptom response, treatment behavior, and secondary use days",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Separation of symptom response, treatment behavior, and secondary use days.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Separation of symptom response, treatment behavior, and secondary use days. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are Chamgap design; M04 §4.6.3, M15 §15.3.1–15.3.3; separation of statuses is Chamgap design; M03 §3.2.3, M08 §8.2.2–8.2.3; Chamgap adaptation",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Keep behavior endpoints and symptom response as different questions. This is a proposal; no new investigation, calculation, or trial was performed."
    },
    {
      "item_id": "N16",
      "question_type": "Evidence condition",
      "question": "Were responder definitions/multiplicity verified in registration and plans?",
      "needed": "Registration, protocol, statistical analysis plan, primary/secondary hierarchy, and changes",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Registration, protocol, statistical analysis plan, primary/secondary hierarchy, and changes.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Registration, protocol, statistical analysis plan, primary/secondary hierarchy, and changes. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M08 Table 8.2.a, M04 §4.6.3; Chamgap application; M04 §4.5–4.6 principles for collecting and selecting materials; separation of access and reading and hyperlink rules are Chamgap's own design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Distinguish planned/changed endpoints, analyses, and time points. This is a proposal; no new investigation, calculation, or trial was performed."
    },
    {
      "item_id": "N17",
      "question_type": "Evidence condition",
      "question": "What is the scope of funding and declared noninvolvement?",
      "needed": "NIHR programme/identifier, support, and role disclosures",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: NIHR programme/identifier, support, and role disclosures.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: NIHR programme/identifier, support, and role disclosures. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "Chamgap's own conditions for independence and attribution. The official methodological sections used in this example do not validate every detail of these items.",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Separate support sources, declared roles, and actual verification level. This is a proposal; no new investigation, calculation, or trial was performed."
    },
    {
      "item_id": "N18",
      "question_type": "Evidence condition",
      "question": "What is the scope of unreported product/device/placebo/commercial analysis support?",
      "needed": "Product/device/placebo supply, commercial analysis, and writing/publication support",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Product/device/placebo supply, commercial analysis, and writing/publication support.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Product/device/placebo supply, commercial analysis, and writing/publication support. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "Chamgap's own conditions for independence and attribution. The official methodological sections used in this example do not validate every detail of these items.",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Distinguish unreported and unverified from absent. This is a proposal; no new investigation, calculation, or trial was performed."
    },
    {
      "item_id": "N19",
      "question_type": "Evidence condition",
      "question": "What were the consultancy-fee and scale-development disclosures?",
      "needed": "Personal consultancy fees, POEM/RECAP development, conflicts, and actual roles",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Personal consultancy fees, POEM/RECAP development, conflicts, and actual roles.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Personal consultancy fees, POEM/RECAP development, conflicts, and actual roles. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "Chamgap independence and attribution conditions; the official methodology sections used in this example do not certify all these detailed items; M08 Table 8.2.a, M03 §3.2.4; Chamgap adaptation",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Record each disclosure separately from actual trial roles. This is a proposal; no new investigation, calculation, or trial was performed."
    },
    {
      "item_id": "N20",
      "question_type": "Evidence condition",
      "question": "Does the earlier pediatric crossover trial ask the same responder question?",
      "needed": "Population, crossover design, duration, different protocol, and SCORAD",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Population, crossover design, duration, different protocol, and SCORAD.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Population, crossover design, duration, different protocol, and SCORAD. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M04 §4.6.1–4.6.2; distinction between studies and reports; cohort and outcome connections are Chamgap adaptations; M03 §3.2.1; detailed population conditions are Chamgap design; M08 §8.1–8.2.3; Chamgap adaptation; M04 §4.6.1–4.6.2, M15 §15.3.1; Chamgap adaptation",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Do not sum the same children or repeated periods as independent trials/participants. This is a proposal; no new investigation, calculation, or trial was performed."
    },
    {
      "item_id": "N21",
      "question_type": "Evidence condition",
      "question": "What were the opposite direction and SCORAD values of the pediatric protocol?",
      "needed": "Differences in historical exposure, immediate occlusive moisturization, scale, and duration",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Differences in historical exposure, immediate occlusive moisturization, scale, and duration.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Differences in historical exposure, immediate occlusive moisturization, scale, and duration. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M03 §3.2.2–3.2.3; reverse-direction marker and test adaptations are Chamgap design; M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are Chamgap design; M04 §4.6.1–4.6.2, M15 §15.3.1; Chamgap adaptation; M04 §4.6.3, M15 §15.3.1–15.3.3; separation of statuses is Chamgap design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Preserve the opposite result from a different moisturization protocol and scale. This is a proposal; no new investigation, calculation, or trial was performed."
    },
    {
      "item_id": "N22",
      "question_type": "Evidence condition",
      "question": "How are the pediatric report’s years, registration, and support preserved?",
      "needed": "Report identity, evidence-list/citation years, registration records, and funding",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Report identity, evidence-list/citation years, registration records, and funding.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Report identity, evidence-list/citation years, registration records, and funding. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M04 §4.6.1–4.6.2; distinction between studies and reports; cohort and outcome connections are Chamgap adaptations; M04 §4.5, §4.6.3; limitations of this conversion follow the review scope and Chamgap design; Chamgap independence and attribution conditions; the official methodology sections used in this example do not certify all these detailed items; M08 Table 8.2.a, M04 §4.6.3; Chamgap adaptation",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Separate year wording, trial identity, and actual verification level. This is a proposal; no new investigation, calculation, or trial was performed."
    },
    {
      "item_id": "N23",
      "question_type": "Evidence condition",
      "question": "Does the review directly answer the same 3-point responder question?",
      "needed": "Included protocols, endpoints, heterogeneity, populations, and designs",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Included protocols, endpoints, heterogeneity, populations, and designs.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Included protocols, endpoints, heterogeneity, populations, and designs. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M04 §4.6.1–4.6.2; distinction between studies and reports; cohort and outcome connections are Chamgap adaptations; M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are Chamgap design; M04 §4.6.1–4.6.2, M15 §15.3.1; Chamgap adaptation; M04 §4.6.3, M15 §15.3.1–15.3.3; separation of statuses is Chamgap design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Distinguish synthesis context from different protocols from the original responder question. This is a proposal; no new investigation, calculation, or trial was performed."
    },
    {
      "item_id": "N24",
      "question_type": "Evidence condition",
      "question": "What are the review’s year, registration, and funding statements?",
      "needed": "Citation/evidence-list years, support/plans, and historical access scope",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Citation/evidence-list years, support/plans, and historical access scope.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Citation/evidence-list years, support/plans, and historical access scope. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M04 §4.5, §4.6.3; limitations of this conversion follow the review scope and Chamgap design; Chamgap independence and attribution conditions; the official methodology sections used in this example do not certify all these detailed items; M08 Table 8.2.a, M04 §4.6.3; Chamgap adaptation; M04 §4.5–4.6; material collection/selection principles; access/reading separation and hyperlink contract are Chamgap design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Distinguish original years, identity, and access history from new material. This is a proposal; no new investigation, calculation, or trial was performed."
    },
    {
      "item_id": "N25",
      "question_type": "Harm-information gaps supplementing the efficacy table",
      "question": "What are the original rates/denominators for the two safety outcomes?",
      "needed": "Treatment changes for worsening, medical advice, people/denominators, and time point",
      "role": "Supplementary",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Treatment changes for worsening, medical advice, people/denominators, and time point.",
      "application_exception": "Addresses safety-material gaps for the selected subclaim. POEM, cream-use days, or parent safety wording do not establish safety or generate new harm incidence or instructions on bathing frequency/treatment behavior.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Treatment changes for worsening, medical advice, people/denominators, and time point. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M19 §19.1.2–19.2.4; Chamgap adaptation; M19 §19.1.2–19.2.4; detailed distinctions are Chamgap design; M19 §19.1.2–19.2.4; Chamgap adaptation; M19 §19.1.2–19.2.4, M04 §4.6.3; Chamgap adaptation",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Distinguish each outcome’s units from POEM responder units. This is a proposal; no new investigation, calculation, or trial was performed."
    },
    {
      "item_id": "N26",
      "question_type": "Harm-information gaps supplementing the efficacy table",
      "question": "Do numerical safety differences establish significant worsening or causality?",
      "needed": "Original unreported CI/P wording, collection, concomitant treatment, and verdict scope",
      "role": "Supplementary",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Original unreported CI/P wording, collection, concomitant treatment, and verdict scope.",
      "application_exception": "Addresses safety-material gaps for the selected subclaim. POEM, cream-use days, or parent safety wording do not establish safety or generate new harm incidence or instructions on bathing frequency/treatment behavior.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Original unreported CI/P wording, collection, concomitant treatment, and verdict scope. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M19 §19.1.2–19.2.4; Chamgap adaptation; M19 §19.2.2–19.2.4, M03 §3.2.3; Chamgap adaptation; M19 §19.2.2–19.2.4; design considerations; detailed confounding records are Chamgap design; Chamgap interpretation boundary; M19 is a reference principle, not execution of an official causality tool",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Separate actual levels of behavior/worsening records, testing, and causality. This is a proposal; no new investigation, calculation, or trial was performed."
    },
    {
      "item_id": "N27",
      "question_type": "Evidence condition",
      "question": "How are reports, crossover periods, and related sheets shared?",
      "needed": "Citation-to-trial/review-to-result linkage and repeated/included relationships",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Citation-to-trial/review-to-result linkage and repeated/included relationships.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Citation-to-trial/review-to-result linkage and repeated/included relationships. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "Study/report distinction in M04 §4.6.1–4.6.2; Cohort/outcome linkage is Chamgap application; M04 §4.6.1–4.6.2 and M15 §15.3.1; Chamgap application",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Distinguish unrecorded unique clinical totals from report entries. This is a proposal; no new investigation, calculation, or trial was performed."
    },
    {
      "item_id": "N28",
      "question_type": "Harm-information gaps supplementing the efficacy table",
      "question": "Are related manuscript links and other products/long-term scopes combined?",
      "needed": "Selected frequency/4-week response, separate manuscripts, climates, and risk groups",
      "role": "Supplementary",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Selected frequency/4-week response, separate manuscripts, climates, and risk groups.",
      "application_exception": "Addresses safety-material gaps for the selected subclaim. POEM, cream-use days, or parent safety wording do not establish safety or generate new harm incidence or instructions on bathing frequency/treatment behavior.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Selected frequency/4-week response, separate manuscripts, climates, and risk groups. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M03 §3.2.1–3.2.4; dose, duration and effect-modification details are Chamgap design; M03 §3.2.4; Chamgap extrapolation boundary; M19 §19.1.2–19.2.4; Chamgap adaptation; M19 §19.1.2–19.2.4; Chamgap adaptation",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Separate other products, environments, and durations from the selected question. This is a proposal; no new investigation, calculation, or trial was performed."
    },
    {
      "item_id": "N29",
      "question_type": "Evidence condition",
      "question": "What is the scope of original verdicts, dates, languages, empty values, and corrections?",
      "needed": "D30, axes/safety, bilingual manuscript, and historical cross-checks/corrections",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: D30, axes/safety, bilingual manuscript, and historical cross-checks/corrections.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: D30, axes/safety, bilingual manuscript, and historical cross-checks/corrections. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M04 §4.5, §4.6.3; current material-conversion limits reflect review scope and our own design; M04 §4.6.3, M15 §15.3.1–15.3.3; status distinctions are our own design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Separate original records from production and correction events. This is a proposal; no new investigation, calculation, or trial was performed."
    },
    {
      "item_id": "N30",
      "question_type": "Evidence condition",
      "question": "What is the reading level of summaries and external original material?",
      "needed": "Original URLs and status of summaries/papers, registration, protocols, statistical analysis plans, and disclosures",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Original URLs and status of summaries/papers, registration, protocols, statistical analysis plans, and disclosures.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Original URLs and status of summaries/papers, registration, protocols, statistical analysis plans, and disclosures. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M04 §4.5–4.6 material collection/selection principles; acquisition/reading separation and hyperlink specifications are internally designed; M04 §4.5, §4.6.3; limits of this material conversion follow the review scope and internal design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Distinguish existence, acquisition, actual reading, and access history. This is a proposal; no new investigation, calculation, or trial was performed."
    }
  ]
}