{
  "schema_version": "chamgap-public-criteria-1.0",
  "title": "Bathing and showering frequency × 4-week mean POEM eczema symptoms: evidence checklist",
  "language": "en",
  "translation_date": "2026-10-11",
  "criteria_version": "1.0",
  "criteria_date": "2026-10-06",
  "condition_origin": "Chamgap's own application conditions",
  "method_sources": [
    {
      "id": "M03",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03",
      "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13",
      "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.",
      "review_level": "Methodological principles stated in existing pilot materials and condition templates were referenced. The methodological text was not reviewed again in this work."
    },
    {
      "id": "M04",
      "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04",
      "section": "§4.5, §4.6.1–4.6.3, MECIR C42",
      "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.",
      "review_level": "Methodological principles stated in existing pilot materials and condition templates were referenced. The methodological text was not reviewed again in this work."
    },
    {
      "id": "M08",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08",
      "section": "§8.1–8.2.3, Table 8.2.a",
      "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.",
      "review_level": "Methodological principles stated in existing pilot materials and condition templates were referenced. The methodological text was not reviewed again in this work."
    },
    {
      "id": "M15",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15",
      "section": "§15.2.4, §15.3.1–15.3.3",
      "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.",
      "review_level": "Methodological principles stated in existing pilot materials and condition templates were referenced. The methodological text was not reviewed again in this work."
    },
    {
      "id": "M19",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19",
      "section": "§19.1.2, §19.2.1–19.2.4",
      "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.",
      "review_level": "Methodological principles stated in existing pilot materials and condition templates were referenced. The methodological text was not reviewed again in this work."
    }
  ],
  "status_dictionary": {
    "Met": "The original content has been reviewed as meeting the conditions. This status is not used in this preparation.",
    "Partly verified": "Some information in the stored summary was linked during preparation; clinical verification or review is not complete.",
    "Unverified": "Required direct values, definitions or materials have not been established within the current storage and reading scope. This does not mean zero effect, no papers or failed access.",
    "Review incomplete": "Review of existing content or actual review incomplete.",
    "Not reported": "Used only when original materials were actually read and the outcome was judged unreported. Not used for external materials unread in this work.",
    "Inaccessible": "Used only when an actual access attempt has a recorded failure. Not used for access that was not attempted in this work.",
    "Insufficient evidence for the conditions": "Indicates insufficient direct materials for the relevant scope or conditions; it is not a new grade.",
    "Not applicable": "Used when the reason it does not apply to the original question is stated.",
    "Conflicting data": "Retains the scope of conflicting statements in original materials; it is not an arbitrary reassessment."
  },
  "requirements": [
    {
      "item_id": "N01",
      "question_type": "Evidence condition",
      "question": "Does this sheet address mean symptoms over 4 weeks after reducing bathing to once or twice weekly?",
      "needed": "Original question, parent comparison, endpoint and timing",
      "role": "Required",
      "role_reason": "Required to record the original information and gaps for this question as an individual condition: Does this sheet address mean symptoms over 4 weeks after reducing bathing to once or twice weekly?",
      "application_exception": "Do not turn the related responder or cream questions into a new verdict, split or independent trial.",
      "criterion": "Preserve the exact question separately from its verdict record.",
      "basis": "M03 §3.1, §3.2.1–3.2.4 question-clarification principles; detailed separation rules are our own design / M03 §3.2.4; our own extension boundary",
      "condition_origin": "Production based on original materials; existing content review remains incomplete",
      "proposed_research": "If the question changes, record the original unit and exclusions separately."
    },
    {
      "item_id": "N02",
      "question_type": "Evidence condition",
      "question": "Are the subclaim grade and parent score and axes separate?",
      "needed": "Actual subclaim fields, absent fields and locations of original parent values",
      "role": "Required",
      "role_reason": "Required to record the original information and gaps for this question as an individual condition: Are the subclaim grade and parent score and axes separate?",
      "application_exception": "Do not copy parent values such as 30 points, E0 and C0 into subclaim-specific fields.",
      "criterion": "Separate actual subclaim values from parent values.",
      "basis": "M03 §3.1, §3.2.1–3.2.4 question-clarification principles; detailed separation rules are our own design / M04 §4.5, §4.6.3; current material-conversion limits reflect review scope and our own design",
      "condition_origin": "Production based on original materials; existing content review remains incomplete",
      "proposed_research": "If subclaim fields are added, distinguish the original version from the new event."
    },
    {
      "item_id": "N03",
      "question_type": "Evidence condition",
      "question": "Do the historical verdict, design limitations and axes constitute the current review?",
      "needed": "Korean and English verdicts, axes, original synthesis and correction history",
      "role": "Required",
      "role_reason": "Required to record the original information and gaps for this question as an individual condition: Do the historical verdict, design limitations and axes constitute the current review?",
      "application_exception": "Do not turn R0 into zero actual studies or historical cross-checking into a passed current review.",
      "criterion": "Distinguish the original verdict and design explanation from the current content review status.",
      "basis": "M04 §4.5, §4.6.3; current material-conversion limits reflect review scope and our own design / M08 §8.1–8.2.3; our own application",
      "condition_origin": "Production based on original materials; existing content review remains incomplete",
      "proposed_research": "If new evidence or a verdict request arrives, distinguish the existing version from the update event."
    },
    {
      "item_id": "N04",
      "question_type": "Evidence condition",
      "question": "Which summaries were read and which external materials remain unread?",
      "needed": "Existence, acquisition, actual reading scope and preservation location of each material",
      "role": "Required",
      "role_reason": "Required to record the original information and gaps for this question as an individual condition: Which summaries were read and which external materials remain unread?",
      "application_exception": "Do not turn a URL or historical public verification narrative into current full-text reading or failed access.",
      "criterion": "Separate reading the local summary from unread external materials.",
      "basis": "M04 §4.5–4.6 material-collection and selection principles; separation of access and reading and hyperlink rules are our own design / M04 §4.5, §4.6.3; current material-conversion limits reflect review scope and our own design",
      "condition_origin": "Production based on original materials; existing content review remains incomplete",
      "proposed_research": "If materials or reading history are added, record only the actual reading level of each material."
    },
    {
      "item_id": "N05",
      "question_type": "Evidence condition",
      "question": "What are the original bibliography, registration and report-year entries?",
      "needed": "Original bibliography and registration, year differences, trial and review identities",
      "role": "Required",
      "role_reason": "Required to record the original information and gaps for this question as an individual condition: What are the original bibliography, registration and report-year entries?",
      "application_exception": "Do not normalize ISRCTN into NCT or invent identifiers for unknown registrations.",
      "criterion": "Preserve original bibliography and registration entries and verification gaps.",
      "basis": "M04 §4.6.1–4.6.2; distinction between studies and reports; cohort and outcome connections are Chamgap adaptations / M04 §4.5, §4.6.3; limitations of this conversion follow the review scope and Chamgap design / M08 Table 8.2.a, M04 §4.6.3; Chamgap adaptation",
      "condition_origin": "Production based on original materials; existing content review remains incomplete",
      "proposed_research": "If original lists are provided, record publication and online years and their relationship to trial identity."
    },
    {
      "item_id": "N06",
      "question_type": "Evidence condition",
      "question": "Who was selected for the UK online trial?",
      "needed": "Diagnosis, age composition, baseline severity, eligibility and exclusions, online recruitment",
      "role": "Required",
      "role_reason": "Required to record the original information and gaps for this question as an individual condition: Who was selected for the UK online trial?",
      "application_exception": "Do not transfer the mixed population aged at least one year into a direct effect for a specific child or adult subgroup.",
      "criterion": "Record the selected population and gaps in detailed representativeness.",
      "basis": "M03 §3.2.1; detailed population conditions are our own design / M03 §3.2.1–3.2.4; dose, persistence and effect-modification details are our own design",
      "condition_origin": "Production based on original materials; existing content review remains incomplete",
      "proposed_research": "If the original population table is provided, distinguish mixed age and severity composition from applicability."
    },
    {
      "item_id": "N07",
      "question_type": "Evidence condition",
      "question": "What were the original frequency intervention and active comparator?",
      "needed": "Assigned frequency, actual performance, comparator composition and comparison direction",
      "role": "Required",
      "role_reason": "Required to record the original information and gaps for this question as an individual condition: What were the original frequency intervention and active comparator?",
      "application_exception": "Do not turn the frequency comparator into no bathing, no treatment or an optimal-frequency recommendation.",
      "criterion": "Preserve the direction of once or twice weekly minus at least six times weekly.",
      "basis": "M03 §3.2.2–3.2.3; reverse-direction labeling and assessment adaptations are our own design / M03 §3.2.3, M08 §8.2.2–8.2.3; our own application",
      "condition_origin": "Production based on original materials; existing content review remains incomplete",
      "proposed_research": "If original performance records are provided, record assigned versus actual exposure and frequency differences."
    },
    {
      "item_id": "N08",
      "question_type": "Evidence condition",
      "question": "Were bathing and showering definitions and other exposures comparable?",
      "needed": "Activity definition, bathing versus showering, temperature and duration, cleansers and environment",
      "role": "Required",
      "role_reason": "Required to record the original information and gaps for this question as an individual condition: Were bathing and showering definitions and other exposures comparable?",
      "application_exception": "Do not copy duration or moisturizer components of pediatric soak-and-seal into the main trial exposure.",
      "criterion": "Separate the frequency comparison from gaps in other exposure components.",
      "basis": "M03 §3.2.2–3.2.3; reverse-direction labeling and assessment adaptations are our own design / M03 §3.2.3, M08 §8.2.2–8.2.3; our own application",
      "condition_origin": "Production based on original materials; existing content review remains incomplete",
      "proposed_research": "If original exposure materials are provided, distinguish frequency from balance in other concurrent components."
    },
    {
      "item_id": "N09",
      "question_type": "Evidence condition",
      "question": "Which comparison included moisturizers and topical treatment?",
      "needed": "Shared treatment, actual use, changes and co-treatment, balance",
      "role": "Required",
      "role_reason": "Required to record the original information and gaps for this question as an individual condition: Which comparison included moisturizers and topical treatment?",
      "application_exception": "Do not write the original continued-use condition as an instruction to continue or stop treatment.",
      "criterion": "Preserve that the frequency comparison included shared treatment.",
      "basis": "M03 §3.2.2–3.2.3; reverse-direction labeling and assessment adaptations are our own design / M03 §3.2.3, M08 §8.2.2–8.2.3; our own application / M19 §19.2.2–19.2.4 design considerations; detailed confounding records are our own design",
      "condition_origin": "Production based on original materials; existing content review remains incomplete",
      "proposed_research": "If original treatment materials are provided, separate shared conditions from differences in use-days and changes."
    },
    {
      "item_id": "N10",
      "question_type": "Evidence condition",
      "question": "Are frequency adherence, crossover and analyses directly verified?",
      "needed": "Actual performance, deviations and crossover, analysis populations, adherence definitions",
      "role": "Required",
      "role_reason": "Required to record the original information and gaps for this question as an individual condition: Are frequency adherence, crossover and analyses directly verified?",
      "application_exception": "Do not certify complete adherence or identical effect estimates from a statement of the same conclusion.",
      "criterion": "Distinguish the original statement of analytical consistency from gaps in direct details.",
      "basis": "M08 §8.2.2, M15 §15.3.1; Chamgap adaptation / M03 §3.2.1–3.2.4; dose, duration and effect-modification details are Chamgap design / M03 §3.2.2–3.2.3; reverse-direction marker and test adaptations are Chamgap design",
      "condition_origin": "Production based on original materials; existing content review remains incomplete",
      "proposed_research": "If original adherence and analysis materials are provided, record the assigned comparison and actual-exposure analyses separately."
    },
    {
      "item_id": "N11",
      "question_type": "Evidence condition",
      "question": "What was the scope of the pragmatic parallel-group design and masking?",
      "needed": "Sequence generation, allocation concealment, assessor and analyst masking, data collection",
      "role": "Required",
      "role_reason": "Required to record the original information and gaps for this question as an individual condition: What was the scope of the pragmatic parallel-group design and masking?",
      "application_exception": "Do not recalculate defect counts or grades from unavoidable unmasking or extend it to all assessment roles.",
      "criterion": "Distinguish the original explanation from current bias-review certification.",
      "basis": "M08 §8.1–8.2.3; Chamgap adaptation / M08 Table 8.2.a, M03 §3.2.4; Chamgap adaptation",
      "condition_origin": "Production based on original materials; existing content review remains incomplete",
      "proposed_research": "If original methods are provided, record the design label and actual role-specific processes."
    },
    {
      "item_id": "N12",
      "question_type": "Evidence condition",
      "question": "What were the randomized denominators and group order?",
      "needed": "Allocation, follow-up and completion, analysis flow, group-specific stages",
      "role": "Required",
      "role_reason": "Required to record the original information and gaps for this question as an individual condition: What were the randomized denominators and group order?",
      "application_exception": "Do not copy 438 randomized participants into every outcome denominator.",
      "criterion": "Separate the original randomized denominators 220/218 from denominators at other stages.",
      "basis": "M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; adaptations by study design are our own design / M08 §8.1–8.2.3; our own application",
      "condition_origin": "Production based on original materials; existing content review remains incomplete",
      "proposed_research": "If the original flow diagram is provided, connect group allocation with endpoint analysis denominators."
    },
    {
      "item_id": "N13",
      "question_type": "Evidence condition",
      "question": "What inclusion rule defined the 388 participants in the primary model?",
      "needed": "Primary-analysis inclusion, responses by time, missingness and model handling",
      "role": "Required",
      "role_reason": "Required to record the original information and gaps for this question as an individual condition: What inclusion rule defined the 388 participants in the primary model?",
      "application_exception": "Do not move 388 into responder or safety denominators or newly calculate attrition.",
      "criterion": "Separate inclusion based on at least one response from each time-specific denominator.",
      "basis": "M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; design-specific adaptations are our own design / M08 §8.2.2, M15 §15.3.1; our own application",
      "condition_origin": "Production based on original materials; existing content review remains incomplete",
      "proposed_research": "If original time-specific flow and models are provided, distinguish primary-analysis inclusion from week-4 responses."
    },
    {
      "item_id": "N14",
      "question_type": "Evidence condition",
      "question": "What are the POEM scale, direction and measured content?",
      "needed": "Original scale, participant or caregiver response, language, entry methods and missing measurements",
      "role": "Required",
      "role_reason": "Required to record the original information and gaps for this question as an individual condition: What are the POEM scale, direction and measured content?",
      "application_exception": "Do not replace POEM with an objective skin examination, SCORAD or infection events.",
      "criterion": "Preserve the symptom-scale direction and separate measurement gaps.",
      "basis": "M03 §3.2.4, M15 §15.3.1–15.3.3; outcome adaptations by question are our own design / M08 Table 8.2.a, M03 §3.2.4; our own application",
      "condition_origin": "Production based on original materials; existing content review remains incomplete",
      "proposed_research": "If original measurement materials are provided, record the scale, respondent roles and collection processes."
    },
    {
      "item_id": "N15",
      "question_type": "Evidence condition",
      "question": "Does the 4-week mean differ from the final week-4 value or change score?",
      "needed": "Weekly collection and mean model, baseline, final and change values, effect of interest",
      "role": "Required",
      "role_reason": "Required to record the original information and gaps for this question as an individual condition: Does the 4-week mean differ from the final week-4 value or change score?",
      "application_exception": "Do not express the adjusted mean −0.4 as a single final week-4 value or an individual change score.",
      "criterion": "Distinguish the repeated-measurement mean from final-time responses.",
      "basis": "M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are Chamgap design / M08 §8.2.2, M15 §15.3.1; Chamgap adaptation",
      "condition_origin": "Production based on original materials; existing content review remains incomplete",
      "proposed_research": "If original models and time tables are provided, separate the repeated-measurement mean from week-4 change and responders."
    },
    {
      "item_id": "N16",
      "question_type": "Evidence condition",
      "question": "What are the primary adjusted difference, interval and P value?",
      "needed": "Original difference direction, adjustment, model and interval",
      "role": "Required",
      "role_reason": "Required to record the original information and gaps for this question as an individual condition: What are the primary adjusted difference, interval and P value?",
      "application_exception": "Do not recalculate group differences, CIs or P values or copy them into responder effects.",
      "criterion": "Assign the original direction, units, 95% CI and P value to the selected mean endpoint.",
      "basis": "M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are our own design / M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; design-specific adaptations are our own design / M15 §15.3.1–15.3.3; our own application",
      "condition_origin": "Production based on original materials; existing content review remains incomplete",
      "proposed_research": "If original analysis methods are provided, connect the original estimate with its observation scope."
    },
    {
      "item_id": "N17",
      "question_type": "Evidence condition",
      "question": "What were the adjustment, repeated-measurement and missing-data models?",
      "needed": "Statistical model, adjustment variables, repeated measures, missingness and sensitivity",
      "role": "Required",
      "role_reason": "Required to record the original information and gaps for this question as an individual condition: What were the adjustment, repeated-measurement and missing-data models?",
      "application_exception": "Do not certify that all confounding or missingness problems are resolved merely because adjustment is stated.",
      "criterion": "Separate the stored estimate from gaps in direct model details.",
      "basis": "M08 §8.2.2, M15 §15.3.1; Chamgap adaptation / M15 §15.3.1–15.3.3; Chamgap adaptation",
      "condition_origin": "Production based on original materials; existing content review remains incomplete",
      "proposed_research": "If the original SAP and model are provided, record actual estimation and missing-data assumptions."
    },
    {
      "item_id": "N18",
      "question_type": "Evidence condition",
      "question": "Is 2.2 points a clinical threshold or a sample-size assumption?",
      "needed": "Original sample-size assumption and separate evidence for clinical importance",
      "role": "Required",
      "role_reason": "Required to record the original information and gaps for this question as an individual condition: Is 2.2 points a clinical threshold or a sample-size assumption?",
      "application_exception": "Do not turn 2.2 into a validated MCID, individual response threshold or criterion excluding every benefit.",
      "criterion": "Preserve both the exclusion of the original assumption and the absence of a validated clinical threshold.",
      "basis": "M15 §15.3.1–15.3.3; Chamgap adaptation / M08 Table 8.2.a, M04 §4.6.3; Chamgap adaptation",
      "condition_origin": "Production based on original materials; existing content review remains incomplete",
      "proposed_research": "If original plans and importance materials are provided, separate the design effect size from a clinical threshold."
    },
    {
      "item_id": "N19",
      "question_type": "Evidence condition",
      "question": "Does the original null result establish zero effect, equivalence or long-term absence of harm?",
      "needed": "Superiority hypothesis, uncertainty, importance and applicability",
      "role": "Required",
      "role_reason": "Required to record the original information and gaps for this question as an individual condition: Does the original null result establish zero effect, equivalence or long-term absence of harm?",
      "application_exception": "Do not turn nonsignificance into zero symptom difference, equivalence or safety at any frequency.",
      "criterion": "Maintain the original null superiority result, interval and 4-week limit.",
      "basis": "M04 §4.6.3, M15 §15.3.1–15.3.3; separation of statuses is Chamgap design / M15 §15.3.1–15.3.3; Chamgap adaptation / M03 §3.2.4; Chamgap extrapolation boundary",
      "condition_origin": "Production based on original materials; existing content review remains incomplete",
      "proposed_research": "If original interpretation evidence is provided, distinguish the statistical result from clinical and temporal extrapolations."
    },
    {
      "item_id": "N20",
      "question_type": "Evidence condition",
      "question": "Is improvement of at least 3 points at week 4 a separate outcome?",
      "needed": "Response definition, week-4 response denominators, adjustment and intervals",
      "role": "Supplementary",
      "role_reason": "Required to record the original information and gaps for this question as an individual condition: Is improvement of at least 3 points at week 4 a separate outcome?",
      "application_exception": "Do not newly calculate original responder rates or differences or turn them into the mean POEM result.",
      "criterion": "Distinguish responder denominators 169/171 from the primary model denominators 193/195.",
      "basis": "M03 §3.2.4, M15 §15.3.1–15.3.3; outcome adaptations by question are our own design / M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; adaptations by study design are our own design / M04 §4.6.3, M15 §15.3.1–15.3.3; separation of statuses is our own design",
      "condition_origin": "Production based on original materials; existing content review remains incomplete",
      "proposed_research": "If the original responder table is provided, connect the mean, responders and their denominators separately."
    },
    {
      "item_id": "N21",
      "question_type": "Evidence condition",
      "question": "Are the 3-point responder definition and 2.2-point planning assumption the same?",
      "needed": "Planned and validated response threshold, mean-difference assumption",
      "role": "Supplementary",
      "role_reason": "Required to record the original information and gaps for this question as an individual condition: Are the 3-point responder definition and 2.2-point planning assumption the same?",
      "application_exception": "Do not promote the original 3-point responder threshold into a newly validated MCID declaration.",
      "criterion": "Separate the responder definition from the sample-size assumption.",
      "basis": "M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are Chamgap design / M15 §15.3.1–15.3.3; Chamgap adaptation / M08 Table 8.2.a, M04 §4.6.3; Chamgap adaptation",
      "condition_origin": "Production based on original materials; existing content review remains incomplete",
      "proposed_research": "If original plans and validation materials are provided, record the role and evidence level of each threshold."
    },
    {
      "item_id": "N22",
      "question_type": "Evidence condition",
      "question": "Do days of flare-control cream use establish symptom benefit?",
      "needed": "Cream types, use-day definitions, denominators, adjustment and endpoint hierarchy",
      "role": "Supplementary",
      "role_reason": "Required to record the original information and gaps for this question as an individual condition: Do days of flare-control cream use establish symptom benefit?",
      "application_exception": "Do not convert use-days into treatment dose reductions, stopping instructions or symptom benefit.",
      "criterion": "Preserve the secondary use-day outcome together with the null primary endpoint.",
      "basis": "M04 §4.6.3, M15 §15.3.1–15.3.3; separation of statuses is Chamgap design / M03 §3.2.4; Chamgap extrapolation boundary / M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are Chamgap design",
      "condition_origin": "Production based on original materials; existing content review remains incomplete",
      "proposed_research": "If original use materials are provided, distinguish use-days, medicine types and amounts, and symptom outcomes."
    },
    {
      "item_id": "N23",
      "question_type": "Evidence condition",
      "question": "Were registration, primary and secondary hierarchy, and multiplicity read directly?",
      "needed": "Registration timing, prespecified endpoints and analyses, changes and multiplicity",
      "role": "Required",
      "role_reason": "Required to record the original information and gaps for this question as an individual condition: Were registration, primary and secondary hierarchy, and multiplicity read directly?",
      "application_exception": "Do not turn a registration string or original primary label into direct certification of prespecified plans.",
      "criterion": "Separate original role labels from unread external plans.",
      "basis": "M08 Table 8.2.a, M04 §4.6.3; our own application / M04 §4.5–4.6 material-collection and selection principles; separation of access and reading and hyperlink rules are our own design",
      "condition_origin": "Production based on original materials; existing content review remains incomplete",
      "proposed_research": "If original registration and plans are provided, distinguish reporting from prespecification."
    },
    {
      "item_id": "N24",
      "question_type": "Evidence condition",
      "question": "How far does the original consistency of missing-data and assigned analyses extend?",
      "needed": "Weekly missingness and attrition reasons, analysis definitions and sensitivity assumptions",
      "role": "Required",
      "role_reason": "Required to record the original information and gaps for this question as an individual condition: How far does the original consistency of missing-data and assigned analyses extend?",
      "application_exception": "Do not turn the same conclusion into identical values for every outcome or absence of missing data.",
      "criterion": "Preserve the original sensitivity narrative together with gaps in missing-data details.",
      "basis": "M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; design-specific adaptations are our own design / M08 §8.2.2, M15 §15.3.1; our own application / M19 §19.1.2–19.2.4, M04 §4.6.3; our own application",
      "condition_origin": "Production based on original materials; existing content review remains incomplete",
      "proposed_research": "If original analyses and flow materials are provided, record denominators, methods and results for each analysis."
    },
    {
      "item_id": "N25",
      "question_type": "Harm information",
      "question": "What was the outcome of changing treatment because of worsening?",
      "needed": "Worsening and treatment-change definitions, original safety denominators, duration and ascertainment",
      "role": "Supplementary",
      "role_reason": "Required to record the original information and gaps for this question as an individual condition: What was the outcome of changing treatment because of worsening?",
      "application_exception": "Do not recalculate change rates or infer treatment types or severity.",
      "criterion": "Preserve safety denominators 165/168 and the numerical direction.",
      "basis": "M19 §19.1.2–19.2.4; Chamgap adaptation / M19 §19.1.2–19.2.4; detailed distinctions are Chamgap design / M19 §19.2.2–19.2.4, M03 §3.2.3; Chamgap adaptation / M19 §19.1.2–19.2.4; Chamgap adaptation",
      "condition_origin": "Production based on original materials; existing content review remains incomplete",
      "proposed_research": "If the original safety table is provided, record treatment-change events, analysis denominators and definitions."
    },
    {
      "item_id": "N26",
      "question_type": "Harm information",
      "question": "What was the outcome of seeking medical advice?",
      "needed": "Medical-advice definition, people versus events, denominator and duration, reporting methods",
      "role": "Supplementary",
      "role_reason": "Required to record the original information and gaps for this question as an individual condition: What was the outcome of seeking medical advice?",
      "application_exception": "Do not turn advice counts into diagnosed worsening, infection or hospitalization or add them to treatment-change events.",
      "criterion": "Preserve denominators 165/170 and the separate event.",
      "basis": "M19 §19.1.2–19.2.4; Chamgap adaptation / M19 §19.1.2–19.2.4; detailed distinctions are Chamgap design / M19 §19.2.2–19.2.4, M03 §3.2.3; Chamgap adaptation / M19 §19.1.2–19.2.4; Chamgap adaptation",
      "condition_origin": "Production based on original materials; existing content review remains incomplete",
      "proposed_research": "If the original safety table is provided, distinguish advice requests from treatment changes and symptom outcomes."
    },
    {
      "item_id": "N27",
      "question_type": "Harm information",
      "question": "Do numerical safety differences establish statistically significant worsening?",
      "needed": "Between-group estimates and intervals, tests and safety-event definitions",
      "role": "Supplementary",
      "role_reason": "Required to record the original information and gaps for this question as an individual condition: Do numerical safety differences establish statistically significant worsening?",
      "application_exception": "Do not calculate or invent new CIs, P values, significance, causal conclusions or absence of harm.",
      "criterion": "Separate the original numerical direction from limits on statistical conclusions.",
      "basis": "Chamgap interpretation boundary; M19 is a reference principle, not execution of an official causality tool / M15 §15.3.1–15.3.3; Chamgap adaptation / M04 §4.6.3, M15 §15.3.1–15.3.3; separation of statuses is Chamgap design",
      "condition_origin": "Production based on original materials; existing content review remains incomplete",
      "proposed_research": "If original safety analyses are provided, distinguish numerical values from statistical uncertainty."
    },
    {
      "item_id": "N28",
      "question_type": "Harm information",
      "question": "What is known about other harms, collection, discontinuation and complete safety records?",
      "needed": "Harm definitions, collection methods, severity, discontinuation and all-event tables",
      "role": "Supplementary",
      "role_reason": "Required to record the original information and gaps for this question as an individual condition: What is known about other harms, collection, discontinuation and complete safety records?",
      "application_exception": "Do not infer complete harm collection or zero other events from the presence of two outcomes.",
      "criterion": "Distinguish the stored safety history from gaps in direct evidence on all harms.",
      "basis": "M19 §19.1.2–19.2.4; detailed distinctions are Chamgap design / M19 §19.1.2–19.2.4, M04 §4.6.3; Chamgap adaptation / M19 §19.1.2–19.2.4; Chamgap adaptation",
      "condition_origin": "Production based on original materials; existing content review remains incomplete",
      "proposed_research": "If original safety materials are provided, distinguish the actual collection scope from unread or unreported information."
    },
    {
      "item_id": "N29",
      "question_type": "Harm information",
      "question": "How far are harm timing, follow-up and recovery documented?",
      "needed": "Safety-event timing, exposure and follow-up windows, discontinuation, recovery and long term",
      "role": "Supplementary",
      "role_reason": "Required to record the original information and gaps for this question as an individual condition: How far are harm timing, follow-up and recovery documented?",
      "application_exception": "Do not turn a null 4-week symptom result into long-term safety or temporal causality certification.",
      "criterion": "Separate short observation from gaps in harm timing and long-term outcomes.",
      "basis": "M19 §19.2 concerns harm questions by study design; temporal-relationship details are our own design / M19 §19.1.2–19.2.4; our own application",
      "condition_origin": "Production based on original materials; existing content review remains incomplete",
      "proposed_research": "If original timing materials are provided, record the relationship of 4 weeks to long-term and individual-event timing."
    },
    {
      "item_id": "N30",
      "question_type": "Harm information",
      "question": "What were the harm comparator, concurrent treatment and alternative explanations?",
      "needed": "Baseline risk, concurrent treatment and environment, event attribution and comparison conditions",
      "role": "Supplementary",
      "role_reason": "Required to record the original information and gaps for this question as an individual condition: What were the harm comparator, concurrent treatment and alternative explanations?",
      "application_exception": "Do not attribute treatment changes or advice requests exclusively and conclusively to bathing frequency.",
      "criterion": "Preserve the actual comparator and gaps in alternative causes.",
      "basis": "M19 §19.2.2–19.2.4, M03 §3.2.3; Chamgap adaptation / M19 §19.2.2–19.2.4 on design considerations; detailed confounding records are a Chamgap design / M03 §3.2.3, M08 §8.2.2–8.2.3; Chamgap adaptation",
      "condition_origin": "Production based on original materials; existing content review remains incomplete",
      "proposed_research": "If original event and co-treatment materials are provided, record the relationship between frequency and other changes."
    },
    {
      "item_id": "N31",
      "question_type": "Harm information",
      "question": "Do safety denominators and missingness differ from efficacy denominators?",
      "needed": "Endpoint-specific responses, missingness, risk populations, duration and aggregation",
      "role": "Supplementary",
      "role_reason": "Required to record the original information and gaps for this question as an individual condition: Do safety denominators and missingness differ from efficacy denominators?",
      "application_exception": "Do not add differing denominators or safety and responder events or turn them into one completion count.",
      "criterion": "Distinguish original endpoint-specific denominators from missing-data gaps.",
      "basis": "M19 §19.1.2–19.2.4; Chamgap adaptation / M19 §19.1.2–19.2.4, M04 §4.6.3; Chamgap adaptation / M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; design-specific adaptations are Chamgap design",
      "condition_origin": "Production based on original materials; existing content review remains incomplete",
      "proposed_research": "If original flow tables are provided, record inclusion rules and missingness for each denominator."
    },
    {
      "item_id": "N32",
      "question_type": "Evidence condition",
      "question": "Did the pediatric crossover trial use the same frequency comparison?",
      "needed": "Original pediatric protocol, population, accompanying moisturizer and comparison differences",
      "role": "Supplementary",
      "role_reason": "Required to record the original information and gaps for this question as an individual condition: Did the pediatric crossover trial use the same frequency comparison?",
      "application_exception": "Do not rewrite the original protocol as treatment steps or copy it into the main trial intervention.",
      "criterion": "Maintain the opposite-direction context of a different protocol with moisturizer.",
      "basis": "M03 §3.2.2–3.2.3; reverse-direction marker and test adaptations are Chamgap design / M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are Chamgap design / M04 §4.6.3, M15 §15.3.1–15.3.3; separation of statuses is Chamgap design / M03 §3.2.4; Chamgap extrapolation boundary",
      "condition_origin": "Production based on original materials; existing content review remains incomplete",
      "proposed_research": "If original protocols are provided, distinguish intervention components and direct versus indirect scope."
    },
    {
      "item_id": "N33",
      "question_type": "Evidence condition",
      "question": "What were the pediatric trial size and SCORAD result?",
      "needed": "SCORAD analysis denominators, difference direction, period-specific and sequence-specific results",
      "role": "Supplementary",
      "role_reason": "Required to record the original information and gaps for this question as an individual condition: What were the pediatric trial size and SCORAD result?",
      "application_exception": "Do not turn SCORAD 21.2 into a POEM effect or main-trial result or aggregate people and periods.",
      "criterion": "Preserve original pediatric size, scale, opposite direction and different conditions.",
      "basis": "M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; design-specific adaptations are Chamgap design / M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are Chamgap design / M04 §4.6.3, M15 §15.3.1–15.3.3; separation of statuses is Chamgap design",
      "condition_origin": "Production based on original materials; existing content review remains incomplete",
      "proposed_research": "If original crossover tables are provided, assign people, periods, denominators and SCORAD to their own materials."
    },
    {
      "item_id": "N34",
      "question_type": "Evidence condition",
      "question": "What is known about crossover sequence, carryover, registration and funding?",
      "needed": "Allocation sequence, washout and carryover, role-specific masking, original registration and funding",
      "role": "Supplementary",
      "role_reason": "Required to record the original information and gaps for this question as an individual condition: What is known about crossover sequence, carryover, registration and funding?",
      "application_exception": "Do not inherit historical abstract verification as current abstract reading or certification of noncommercial independence.",
      "criterion": "Preserve original unverified registration and funding entries and crossover-detail gaps.",
      "basis": "M08 §8.1–8.2.3; Chamgap adaptation / M08 §8.2.2, M15 §15.3.1; Chamgap adaptation / M08 Table 8.2.a, M04 §4.6.3; Chamgap adaptation / Chamgap independence and attribution conditions; the official methodology sections used in this example do not certify all these detailed items",
      "condition_origin": "Production based on original materials; existing content review remains incomplete",
      "proposed_research": "If original methods and declarations are provided, record crossover, institutional and registration details and the verification scope."
    },
    {
      "item_id": "N35",
      "question_type": "Evidence condition",
      "question": "Does the review of 13 studies establish 13 independent direct RCTs?",
      "needed": "Review inclusion table, original study and population identities, designs and outcome lists",
      "role": "Supplementary",
      "role_reason": "Required to record the original information and gaps for this question as an individual condition: Does the review of 13 studies establish 13 independent direct RCTs?",
      "application_exception": "Do not count 13 studies as 13 independent RCTs or add them to direct trials as a replication total.",
      "criterion": "Distinguish original paper and study wording from unique trial counts.",
      "basis": "M04 §4.6.1–4.6.2; distinction between studies and reports; cohort and outcome connections are Chamgap adaptations / M04 §4.6.1–4.6.2, M15 §15.3.1; Chamgap adaptation / M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are Chamgap design",
      "condition_origin": "Production based on original materials; existing content review remains incomplete",
      "proposed_research": "If original inclusion lists are provided, connect the review report with individual unique study families."
    },
    {
      "item_id": "N36",
      "question_type": "Evidence condition",
      "question": "What did the review conclude about heterogeneity and optimal frequency?",
      "needed": "Condition and design differences, study-specific results, pooled models and intervals, heterogeneity",
      "role": "Supplementary",
      "role_reason": "Required to record the original information and gaps for this question as an individual condition: What did the review conclude about heterogeneity and optimal frequency?",
      "application_exception": "Do not turn background associations into optimal-frequency recommendations or safety advice for all populations.",
      "criterion": "Preserve the original uncertain conclusion and heterogeneous background evidence.",
      "basis": "M04 §4.6.3, M15 §15.3.1–15.3.3; separation of statuses is Chamgap design / M04 §4.6.1–4.6.2, M15 §15.3.1; Chamgap adaptation / M03 §3.2.1–3.2.4; dose, duration and effect-modification details are Chamgap design",
      "condition_origin": "Production based on original materials; existing content review remains incomplete",
      "proposed_research": "If original review tables are provided, separate results for the same question from those under different conditions."
    },
    {
      "item_id": "N37",
      "question_type": "Evidence condition",
      "question": "Is independent replication across reports, reviews and populations established?",
      "needed": "Related reports, included trials and populations, repeat citations and independent harm records",
      "role": "Required",
      "role_reason": "Required to record the original information and gaps for this question as an individual condition: Is independent replication across reports, reviews and populations established?",
      "application_exception": "Do not count the same people, periods, review, related tables or material slots as new independent trials.",
      "criterion": "Keep report slots separate from undetermined unique trial and participant counts.",
      "basis": "M04 §4.6.1–4.6.2 distinction between studies and reports; cohort and outcome linking is our own application / M04 §4.6.1–4.6.2, M15 §15.3.1; our own application / M04 §4.6.1–4.6.2; harm-material adaptations are our own design",
      "condition_origin": "Production based on original materials; existing content review remains incomplete",
      "proposed_research": "If original lists are provided, distinguish reports, unique study families and overlap."
    },
    {
      "item_id": "N38",
      "question_type": "Evidence condition",
      "question": "Does the evidence answer persistence, discontinuation or long-term symptoms after 4 weeks?",
      "needed": "Long-term follow-up, discontinuation and frequency changes, symptoms and harms, same-cohort follow-up",
      "role": "Supplementary",
      "role_reason": "Required to record the original information and gaps for this question as an individual condition: Does the evidence answer persistence, discontinuation or long-term symptoms after 4 weeks?",
      "application_exception": "Do not expand a null 4-week result into null effects or equivalence under every long-term condition.",
      "criterion": "Distinguish the selected duration from gaps in direct long-term evidence.",
      "basis": "M03 §3.2.1–3.2.4; dose, duration and effect-modification details are Chamgap design / M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are Chamgap design / M19 §19.1.2–19.2.4; Chamgap adaptation",
      "condition_origin": "Production based on original materials; existing content review remains incomplete",
      "proposed_research": "If long-term materials are provided, record same-family follow-up separately from new trials."
    },
    {
      "item_id": "N39",
      "question_type": "Evidence condition",
      "question": "What is known about hot and humid environments, infection risk and subgroups?",
      "needed": "Environment, infection risk, age and severity denominators, prespecified interactions",
      "role": "Supplementary",
      "role_reason": "Required to record the original information and gaps for this question as an individual condition: What is known about hot and humid environments, infection risk and subgroups?",
      "application_exception": "Do not copy general online-trial results into specific infection, climate or subgroup effects.",
      "criterion": "Preserve original applicability limits and gaps in direct evidence.",
      "basis": "M03 §3.2.1; detailed population conditions are Chamgap design / M03 §3.2.1–3.2.4; dose, duration and effect-modification details are Chamgap design / M19 §19.1.2–19.2.4; Chamgap adaptation",
      "condition_origin": "Production based on original materials; existing content review remains incomplete",
      "proposed_research": "If direct materials for these populations are provided, distinguish overall results from effects and harms under separate conditions."
    },
    {
      "item_id": "N40",
      "question_type": "Evidence condition",
      "question": "What was the scope of public funding, supplies and analysis roles?",
      "needed": "Original funding and role declarations, supply and analysis contracts, data access",
      "role": "Required",
      "role_reason": "Required to record the original information and gaps for this question as an individual condition: What was the scope of public funding, supplies and analysis roles?",
      "application_exception": "Do not turn public funding or I2 into current independence review or certification of no interests.",
      "criterion": "Separate original support and noninvolvement statements from unread external declarations.",
      "basis": "CHAMGAP's own independence and attribution conditions. Official methodological sections used in this pilot do not guarantee every detail of this item / M04 §4.6.1–4.6.2, M15 §15.3.1; our own application",
      "condition_origin": "Production based on original materials; existing content review remains incomplete",
      "proposed_research": "If original declarations are provided, record institutions, roles and disclosure scopes for supplies and analysis."
    },
    {
      "item_id": "N41",
      "question_type": "Evidence condition",
      "question": "What were the author consulting fees and scale-development disclosures?",
      "needed": "Original author declarations, scale development and use, consulting relationships and roles",
      "role": "Required",
      "role_reason": "Required to record the original information and gaps for this question as an individual condition: What were the author consulting fees and scale-development disclosures?",
      "application_exception": "Do not automatically infer bias magnitude, null effects or absence of disclosure from scale development or consulting disclosures.",
      "criterion": "Record original disclosures and their verification level unchanged.",
      "basis": "Chamgap's own independence and attribution conditions. The official method sections used in this pilot do not endorse all of these detailed items / M04 §4.5, §4.6.3; limitations in the current material conversion concern review scope and Chamgap design",
      "condition_origin": "Production based on original materials; existing content review remains incomplete",
      "proposed_research": "If original declarations are provided, record author-specific disclosures and actual research roles."
    },
    {
      "item_id": "N42",
      "question_type": "Evidence condition",
      "question": "How is unverified review funding preserved?",
      "needed": "Original review funding, COI and role declarations",
      "role": "Supplementary",
      "role_reason": "Required to record the original information and gaps for this question as an individual condition: How is unverified review funding preserved?",
      "application_exception": "Do not infer public funding, no funding or independence from an unknown funding source.",
      "criterion": "Maintain unverified original funding and registration entries.",
      "basis": "Chamgap's own independence and attribution conditions. The official method sections used in this pilot do not endorse all of these detailed items / M04 §4.5, §4.6.3; limitations in the current material conversion concern review scope and Chamgap design",
      "condition_origin": "Production based on original materials; existing content review remains incomplete",
      "proposed_research": "If original declarations are provided, distinguish previous unverified information from new material contents."
    },
    {
      "item_id": "N43",
      "question_type": "Evidence condition",
      "question": "Are links to other product verdicts evidence for this trial?",
      "needed": "Intervention-specific questions, original links and separate contexts",
      "role": "Supplementary",
      "role_reason": "Required to record the original information and gaps for this question as an individual condition: Are links to other product verdicts evidence for this trial?",
      "application_exception": "Do not click or test the original links or repurpose other product results as new frequency effects.",
      "criterion": "Preserve only the separate original product context without creating new questions or trials.",
      "basis": "M03 §3.1, §3.2.1–3.2.4; question-clarification principle; detailed separation rules are Chamgap design / M04 §4.6.1–4.6.2; distinction between studies and reports; cohort and outcome connections are Chamgap adaptations / M03 §3.2.4; Chamgap extrapolation boundary",
      "condition_origin": "Production based on original materials; existing content review remains incomplete",
      "proposed_research": "If separate materials are requested, distinguish the original unit of each intervention and question."
    },
    {
      "item_id": "N44",
      "question_type": "Evidence condition",
      "question": "How are dates, corrections, Korean and English wording, and empty values preserved?",
      "needed": "Original dates and empty values, corrections, current reading and update scope",
      "role": "Required",
      "role_reason": "Required to record the original information and gaps for this question as an individual condition: How are dates, corrections, Korean and English wording, and empty values preserved?",
      "application_exception": "Do not reuse historical dates or cross-checking as a current clinical verification date or certify absence of all corrections from an empty correction array.",
      "criterion": "Preserve the original history together with current content-review status and work scope.",
      "basis": "M04 §4.5, §4.6.3; limitations of this conversion follow the review scope and Chamgap design / M03 §3.1, §3.2.1–3.2.4; question-clarification principle; detailed separation rules are Chamgap design / Chamgap interpretation boundary; M19 is a reference principle, not execution of an official causality tool",
      "condition_origin": "Production based on original materials; existing content review remains incomplete",
      "proposed_research": "If actual evidence updates are provided, separate the complete original version from new correction events."
    }
  ]
}