{
  "schema_version": "chamgap-public-evidence-check-1.0",
  "public_id": "v2947-s2",
  "verdict_number": "2947",
  "title": "Reduced bathing/showering frequency × weekly flare-control cream-use days: evidence checklist",
  "view_version": "1.0",
  "view_created_date": "2026-10-11",
  "criteria_version": "1.0",
  "criteria_date": "2026-10-06",
  "review_date": null,
  "legacy_evidence_date": "2026-08-26",
  "review_scope": {
    "materials_read": "Existing review summaries and stored records of methodological application",
    "clinical_papers_directly_read": false,
    "new_clinical_search": false,
    "limitation": "The original content review remains incomplete. External abstracts, full texts, registrations, protocols, and SAPs remain unread, and access was not attempted. Separate content, screen, and link reviews were not performed at the time.",
    "date_meaning": "This is the date the stored materials were checked, not the date of a new search of the clinical literature."
  },
  "claim_context": {
    "population": "Same UK online trial; age at least 1 year and POEM at least 3; baseline cream/respondent information unverified",
    "intervention": "Original study: once-or-twice-weekly baths/showers, 4-week comparison; no treatment-behavior implementation guidance",
    "dose": null,
    "comparator": "At least six times weekly; both arms continued existing moisturizers/topical treatment",
    "endpoint": "Secondary result of mean flare-control cream-use days per week; distinct from symptoms, worsening, and harms",
    "duration": "Four-week study; exact use-day collection/averaging period unverified",
    "excluded_extensions": [
      "Treating 3-point responders, mean POEM, the 2.2-point power assumption, and cream-use days as the same estimand, threshold, or hierarchy",
      "Elevating 2.2 points to a validated minimal clinically important difference or an importance threshold for responders/use days",
      "Calculating new RD/RR/CI/P/totals from original rates/events, doses/frequencies/amounts from use days, or hypothetical values",
      "Reusing allocation 438 (220/218), primary model 388 (193/195), responders 169/171, or safety 165/168/170 as the unverified cream-use denominator",
      "Using mean P=.30 as responder/cream P, or inheriting the general sensitivity narrative as review of all selected endpoints",
      "Converting reduced cream-use days into symptom/worsening/safety benefit or instructions to reduce/stop treatment",
      "Converting numerical directions of the two safety results or original unreported CI/P into significant worsening, causality, or safety certification",
      "Reusing pediatric crossover 42/40 participants, 2 weeks, different frequency/duration with immediate occlusive moisturization, or SCORAD as direct effects for the current frequency/POEM responder/cream question",
      "Converting pediatric evidence-list 2019/citation 2020 or review evidence-list 2020/citation 2021 year differences into new trials, added citations, or automatic corrections",
      "Summing the same people, arms, weeks, crossover periods, citations, review, related sheets, or 2887/2426 links as new independent trials/participants",
      "Converting registration “could not confirm”/“not applicable,” unreported support, historical public checks, or conflicts into current identity, absence, independence, or external-reading certification",
      "Inheriting parent D30, original axes, or cross-checks as subclaim D grades/C scores/axes or current content review",
      "Extending to optimal frequency, long-term/hot-humid/high-infection-risk settings, or effects/safety of other products/devices",
      "New evidence/reassessment or instructions on bathing/showering frequency, application/moisturization, treatment use, or treatment implementation"
    ]
  },
  "requirements": [
    {
      "item_id": "N01",
      "question_type": "Evidence condition",
      "question": "Which existing cream-use-day question and verdict are preserved?",
      "needed": "Separation of the selected C grade/note from parent D30 and other subclaims",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Separation of the selected C grade/note from parent D30 and other subclaims.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Separation of the selected C grade/note from parent D30 and other subclaims. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M03 §3.1, §3.2.1–3.2.4 question-clarification principles; detailed separation rules are internally designed; M04 §4.5, §4.6.3; limits of this material conversion follow the review scope and internal design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Update the question, assessment record and assessment context separately. This is a proposal; no new investigation, calculation or trial was performed.",
      "current_reports": [
        "S01",
        "S02",
        "S03"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "The selected existing subclaim is that reducing bathing to once or twice weekly lowers days of flare-control cream use. Its original wording, C grade, and note that the secondary result was not elevated to symptom benefit are preserved.",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. The subclaim has no score/status/axis fields; parent D30 does not fill them. Mean POEM and 3-point responders, both D, are separate results. The original content review remains incomplete.",
      "missingness": "The subclaim has no score/status/axis fields; parent D30 does not fill them. Mean POEM and 3-point responders, both D, are separate results.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Correction records for the selected entry and parent manuscript"
    },
    {
      "item_id": "N02",
      "question_type": "Evidence condition",
      "question": "Who were the actual population, recruits, and respondents?",
      "needed": "Age at least 1 year, POEM criterion, online recruitment, baseline, and proxy responses",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Age at least 1 year, POEM criterion, online recruitment, baseline, and proxy responses.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Age at least 1 year, POEM criterion, online recruitment, baseline, and proxy responses. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M03 §3.2.1; detailed population conditions are Chamgap design; M08 Table 8.2.a, M03 §3.2.4; Chamgap adaptation",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Record baseline use and representativeness of the selected population within the material scope. This is a proposal; no new investigation, calculation, or trial was performed.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "The original scope was a UK-wide online trial of 438 people aged at least 1 year with POEM scores of at least 3.",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. Age/diagnosis, baseline cream use, recruitment/exclusions, child proxy responses, and the role of cream-use recorders are unverified. The original content review remains incomplete.",
      "missingness": "Age/diagnosis, baseline cream use, recruitment/exclusions, child proxy responses, and the role of cream-use recorders are unverified.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Recruitment/baseline characteristics and cream-recording procedures"
    },
    {
      "item_id": "N03",
      "question_type": "Evidence condition",
      "question": "How did assigned frequency differ from actual exposure?",
      "needed": "Once or twice weekly/at least six times weekly, 4 weeks, actual adherence, and changes",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Once or twice weekly/at least six times weekly, 4 weeks, actual adherence, and changes.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Once or twice weekly/at least six times weekly, 4 weeks, actual adherence, and changes. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M03 §3.2.2–3.2.3; Reverse-direction labels and assessment adaptation are Chamgap design; M03 §3.2.3 and M08 §8.2.2–8.2.3; Chamgap application",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Distinguish material on nominal assignment from actual exposure. This is a proposal; no new investigation, calculation, or trial was performed.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "The comparison of once or twice weekly with at least six times weekly over 4 weeks describes historical study conditions. It does not create instructions on washing frequency or treatment behavior.",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. Actual bath/shower frequency, duration/temperature, adherence/changes, and additional exposure are unverified. The original content review remains incomplete.",
      "missingness": "Actual bath/shower frequency, duration/temperature, adherence/changes, and additional exposure are unverified.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Exposure, adherence, and arm-specific change records"
    },
    {
      "item_id": "N04",
      "question_type": "Evidence condition",
      "question": "How did common topical treatment relate to the cream endpoint?",
      "needed": "Moisturizers, usual topical treatment, selected use days, and arm-specific changes",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Moisturizers, usual topical treatment, selected use days, and arm-specific changes.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Moisturizers, usual topical treatment, selected use days, and arm-specific changes. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M03 §3.2.3, M08 §8.2.2–8.2.3; own application; M03 §3.2.2–3.2.3; reverse-direction labels and test adaptations are our own design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Distinguish frequency effects from concomitant treatment/treatment behavior. This is a proposal; no new investigation, calculation, or trial was performed.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "Both arms continued usual moisturizers and topical treatment. Reduced use days are not a result instructing cessation of baseline treatment.",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. Details of concomitant treatment, cream identity/intensity, additional/rescue prescriptions, and arm-specific changes are unverified. The original content review remains incomplete.",
      "missingness": "Details of concomitant treatment, cream identity/intensity, additional/rescue prescriptions, and arm-specific changes are unverified.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Treatment/cream-use and change records by arm"
    },
    {
      "item_id": "N05",
      "question_type": "Evidence condition",
      "question": "Which question did trial design and allocation assess?",
      "needed": "Online parallel groups, superiority, allocation/concealment, and baseline balance",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Online parallel groups, superiority, allocation/concealment, and baseline balance.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Online parallel groups, superiority, allocation/concealment, and baseline balance. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M08 §8.1–8.2.3; Chamgap adaptation; M08 Table 8.2.a, M04 §4.6.3; Chamgap adaptation",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Separate the overall design from the analysis specification of the selected secondary result. This is a proposal; no new investigation, calculation, or trial was performed.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "The online pragmatic parallel-group randomized superiority trial allocated 438 people as 220/218. POEM was primary and cream-use days secondary.",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. Allocation conduct, baseline cream balance, concealment, and secondary-testing plans are unverified. The original content review remains incomplete.",
      "missingness": "Allocation conduct, baseline cream balance, concealment, and secondary-testing plans are unverified.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Allocation/baseline tables and primary/secondary hypothesis plans"
    },
    {
      "item_id": "N06",
      "question_type": "Evidence condition",
      "question": "What limits arise from impossible masking and use-day recording?",
      "needed": "Recorder, collection method, and participant/assessor/analyst masking",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Recorder, collection method, and participant/assessor/analyst masking.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Recorder, collection method, and participant/assessor/analyst masking. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M08 Table 8.2.a, M03 §3.2.4; internal application",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Record actual limits of treatment behavior and measurement. This is a proposal; no new investigation, calculation, or trial was performed.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "Participant masking was impossible given assigned frequency; the manuscript did not count it as a separate defect.",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. Cream-recording methods, self/proxy reports, diaries/recall, assessor/analyst masking, and arm-specific collection differences are unverified. The original content review remains incomplete.",
      "missingness": "Cream-recording methods, self/proxy reports, diaries/recall, assessor/analyst masking, and arm-specific collection differences are unverified.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Cream-recording and masking/collection procedures"
    },
    {
      "item_id": "N07",
      "question_type": "Evidence condition",
      "question": "What unit is a day of flare-control cream use?",
      "needed": "Cream definition, classification of a use day, days per week, and observation period",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Cream definition, classification of a use day, days per week, and observation period.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Cream definition, classification of a use day, days per week, and observation period. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are our own design; M08 Table 8.2.a, M03 §3.2.4; our own application",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Preserve the units and period of the treatment-behavior endpoint. This is a proposal; no new investigation, calculation, or trial was performed.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "The manuscript reports mean days of flare-control cream use per week. This is distinct from amount used, application frequency, potency, or symptom scores.",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. Medication classification, ingredient/potency, definition of a use day, and averaging/collection periods are unverified. Days are not converted into doses or amounts. The original content review remains incomplete.",
      "missingness": "Medication classification, ingredient/potency, definition of a use day, and averaging/collection periods are unverified. Days are not converted into doses or amounts.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Use-day definition and recording/results tables"
    },
    {
      "item_id": "N08",
      "question_type": "Evidence condition",
      "question": "What were the original mean use-day difference and interval?",
      "needed": "Arm correspondence, adjustment, direction, and original CI",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Arm correspondence, adjustment, direction, and original CI.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Arm correspondence, adjustment, direction, and original CI. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M08 §8.2.2, M15 §15.3.1; Chamgap application; M15 §15.3.1–15.3.3; Chamgap application; M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; design-specific adaptations are Chamgap's own design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Connect the original difference, direction, and interval with that secondary analysis. This is a proposal; no new investigation, calculation, or trial was performed.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "Original Korean/English values are preserved: mean use was 0.5 days per week lower in the once-or-twice-weekly arm, CI −0.8 to −0.1. The English manuscript describes an adjusted mean.",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. Arm-specific means/variances, adjustment variables/model, selected-result P value, and analysis denominator are unverified. No new difference/CI/P/total use days are calculated. The original content review remains incomplete.",
      "missingness": "Arm-specific means/variances, adjustment variables/model, selected-result P value, and analysis denominator are unverified. No new difference/CI/P/total use days are calculated.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Adjusted cream results table and statistical analysis plan"
    },
    {
      "item_id": "N09",
      "question_type": "Evidence condition",
      "question": "What is the level of secondary-result hierarchy and multiplicity?",
      "needed": "Prespecified secondary definition, testing hypotheses, multiple comparisons, and changes",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Prespecified secondary definition, testing hypotheses, multiple comparisons, and changes.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Prespecified secondary definition, testing hypotheses, multiple comparisons, and changes. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M08 Table 8.2.a, M04 §4.6.3; Chamgap adaptation; M15 §15.3.1–15.3.3; Chamgap adaptation",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Distinguish material on primary/secondary results from selective reporting/plans. This is a proposal; no new investigation, calculation, or trial was performed.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "The manuscript explicitly described cream-use days as secondary, separate from the null primary symptom result.",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. Prespecified cream definitions/analysis, number of endpoints, multiplicity adjustment, and change history are unverified. The interval alone does not create a new confirmatory grade. The original content review remains incomplete.",
      "missingness": "Prespecified cream definitions/analysis, number of endpoints, multiplicity adjustment, and change history are unverified. The interval alone does not create a new confirmatory grade.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Registration, protocol, statistical analysis plan, and secondary hierarchy"
    },
    {
      "item_id": "N10",
      "question_type": "Evidence condition",
      "question": "Do fewer use days mean symptom benefit or reduced worsening?",
      "needed": "Behavior endpoint, symptoms, worsening/harms, and interpretation scope",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Behavior endpoint, symptoms, worsening/harms, and interpretation scope.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Behavior endpoint, symptoms, worsening/harms, and interpretation scope. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M04 §4.6.3, M15 §15.3.1–15.3.3; separation of statuses is Chamgap design; M03 §3.2.4; Chamgap extrapolation boundary; M15 §15.3.1–15.3.3; Chamgap adaptation",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Record behavior change separately from patient outcomes. This is a proposal; no new investigation, calculation, or trial was performed.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "The manuscript did not convert 0.5 fewer days per week into primary symptom benefit. The note for selected C preserves that scope.",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. Reasons for recorded use-day reduction, individual linkage with symptoms/worsening, and importance thresholds are unverified. Reduced treatment use is not elevated to clinical benefit, safety, or instructions for use. The original content review remains incomplete.",
      "missingness": "Reasons for recorded use-day reduction, individual linkage with symptoms/worsening, and importance thresholds are unverified. Reduced treatment use is not elevated to clinical benefit, safety, or instructions for use.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Reasons for use days, symptom/worsening linkage, and importance material"
    },
    {
      "item_id": "N11",
      "question_type": "Evidence condition",
      "question": "What separate results are primary mean POEM and the 2.2-point assumption?",
      "needed": "Four-week mean, scale, original CI/P, and power assumption",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Four-week mean, scale, original CI/P, and power assumption.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Four-week mean, scale, original CI/P, and power assumption. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are Chamgap design; M15 §15.3.1–15.3.3; Chamgap adaptation; M04 §4.6.3, M15 §15.3.1–15.3.3; separation of statuses is Chamgap design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Keep continuous symptoms and treatment-use days separate. This is a proposal; no new investigation, calculation, or trial was performed.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "The primary mean POEM difference −0.4 points (95% CI −1.3 to 0.4), P=.30, and exclusion of the assumed 2.2-point sample-size difference are preserved. The 2.2-point value is not a validated minimal clinically important difference.",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. These score differences/assumptions are not transferred into effect, importance, or power thresholds for 0.5 use days. The original content review remains incomplete.",
      "missingness": "These score differences/assumptions are not transferred into effect, importance, or power thresholds for 0.5 use days.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Separate prespecified definitions and result tables for mean POEM/cream"
    },
    {
      "item_id": "N12",
      "question_type": "Evidence condition",
      "question": "Are 3-point responders mixed with reduced cream use?",
      "needed": "Threshold response, counts/denominators, original RD/RR, and use-day differences",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Threshold response, counts/denominators, original RD/RR, and use-day differences.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Threshold response, counts/denominators, original RD/RR, and use-day differences. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are Chamgap design; M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; design-specific adaptations are Chamgap design; M04 §4.6.3, M15 §15.3.1–15.3.3; separation of statuses is Chamgap design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Record the different units/questions of responders and use days. This is a proposal; no new investigation, calculation, or trial was performed.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "Week-4 responders 97/169 (57.4%) versus 91/171 (53.2%), adjusted RD 3.5 percentage points (CI −6.6 to 13.6), and RR 1.06 (CI 0.89 to 1.28) are a separate POEM result.",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. Responder counts, denominators, and RR are not used as counts/denominators/effects for cream users. Individual linkage between the two results is unverified. The original content review remains incomplete.",
      "missingness": "Responder counts, denominators, and RR are not used as counts/denominators/effects for cream users. Individual linkage between the two results is unverified.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Endpoint-specific denominators and response/use-day linkage"
    },
    {
      "item_id": "N13",
      "question_type": "Evidence condition",
      "question": "What were the cream-use-day analysis denominator and missingness?",
      "needed": "Allocation, recording, completion, analysis, and weekly/week-4 denominators",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Allocation, recording, completion, analysis, and weekly/week-4 denominators.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Allocation, recording, completion, analysis, and weekly/week-4 denominators. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M08 Table 8.2.a, M15 §15.3 and M19 §19.1.2–19.2.4; Design-specific adaptation is Chamgap design; M08 §8.2.2 and M15 §15.3.1; Chamgap application",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Link recorder/time-specific denominators separately if material is supplied. This is a proposal; no new investigation, calculation, or trial was performed.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "Original values describe 438 people allocated as 220/218 and a primary model of 388 (193/195) with at least one follow-up POEM.",
      "condition_status": "Unverified",
      "status_reason": "Currently required information in the stored summary is unverified. Arm-specific cream-use-day analysis/recording denominators, reasons for missingness, and handling are unverified. Primary-model, responder, or safety denominators are not automatically reused. The original content review remains incomplete.",
      "missingness": "Arm-specific cream-use-day analysis/recording denominators, reasons for missingness, and handling are unverified. Primary-model, responder, or safety denominators are not automatically reused.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Cream-endpoint flow and denominator/missingness tables"
    },
    {
      "item_id": "N14",
      "question_type": "Evidence condition",
      "question": "Were analysis populations, adjustment, and sensitivity verified for cream?",
      "needed": "Effect of interest, ITT/PP, model, and missingness/sensitivity scope",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Effect of interest, ITT/PP, model, and missingness/sensitivity scope.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Effect of interest, ITT/PP, model, and missingness/sensitivity scope. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M08 §8.2.2 and M15 §15.3.1: in-house application; M08 Table 8.2.a, M15 §15.3 and M19 §19.1.2–19.2.4: design-specific adaptation is in-house.",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Distinguish endpoint-specific analysis from the general narrative. This is a proposal; no new investigation, calculation, or trial was performed.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "The manuscript generally states that allocation-based analysis and missing-data sensitivity gave the same conclusion. The English cream result is described as an adjusted mean.",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. Cream-specific analysis populations/models/sensitivity values and ITT/PP definitions are unverified. General POEM context is not inherited as full confirmation of selected use days. The original content review remains incomplete.",
      "missingness": "Cream-specific analysis populations/models/sensitivity values and ITT/PP definitions are unverified. General POEM context is not inherited as full confirmation of selected use days.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Cream analysis/statistical analysis plan and original sensitivity results"
    },
    {
      "item_id": "N15",
      "question_type": "Evidence condition",
      "question": "Were registration, plans, and changes actually compared?",
      "needed": "ISRCTN, prespecified cream definition, primary/secondary plans, and statistical analysis plan",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: ISRCTN, prespecified cream definition, primary/secondary plans, and statistical analysis plan.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: ISRCTN, prespecified cream definition, primary/secondary plans, and statistical analysis plan. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M08 Table 8.2.a, M04 §4.6.3; Chamgap application; M04 §4.5–4.6 principles for collecting and selecting materials; separation of access and reading and hyperlink rules are Chamgap's own design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Separate prespecification, actual reporting, changes, and the level of supplied material. This is a proposal; no new investigation, calculation, or trial was performed.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "ISRCTN12016473 is preserved as originally recorded. The original summary of secondary cream-use days is linked.",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. Registration, protocol, statistical analysis plan, and change history remain unread; access was not attempted. An identifier does not establish completed comparison of plans/multiplicity. The original content review remains incomplete.",
      "missingness": "Registration, protocol, statistical analysis plan, and change history remain unread; access was not attempted. An identifier does not establish completed comparison of plans/multiplicity.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Registration history, protocol, and SAP"
    },
    {
      "item_id": "N16",
      "question_type": "Evidence condition",
      "question": "What was declared about NIHR support and noninvolvement?",
      "needed": "Funding programme/identifier, roles, and actual verification scope",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Funding programme/identifier, roles, and actual verification scope.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Funding programme/identifier, roles, and actual verification scope. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "Chamgap's own conditions for independence and attribution. The official methodological sections used in this example do not validate every detail of these items.",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Separate support and declared noninvolvement from actual verification level. This is a proposal; no new investigation, calculation, or trial was performed.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "Original wording gives NIHR Programme Grants for Applied Research, NIHR203279, and no role in design, collection, analysis, publication decisions, or writing.",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. Contracts/items, actual-role comparisons, and additional support are unverified. Declarations/public funding do not certify every aspect of independence. The original content review remains incomplete.",
      "missingness": "Contracts/items, actual-role comparisons, and additional support are unverified. Declarations/public funding do not certify every aspect of independence.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original funding and role disclosures"
    },
    {
      "item_id": "N17",
      "question_type": "Evidence condition",
      "question": "What is the scope of unreported commercial supply and personal conflicts?",
      "needed": "Products/devices/placebos, analysis services, personal consultancy, and scale development",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Products/devices/placebos, analysis services, personal consultancy, and scale development.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Products/devices/placebos, analysis services, personal consultancy, and scale development. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "Chamgap independence and attribution conditions; the official methodology sections used in this example do not certify all these detailed items; M08 Table 8.2.a, M03 §3.2.4; Chamgap adaptation",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Separate disclosed items from actual trial/result roles. This is a proposal; no new investigation, calculation, or trial was performed.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "The manuscript preserves unreported product/device/placebo supply and commercial analysis services, E.J.M./AbbVie consultancy fees, and H.C.W./POEM and L.H./K.S.T./RECAP development disclosures.",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. Absence, influence, amounts, individual employment/patents, and writing/publication support have not been newly verified. Disclosures do not automatically invalidate results or certify independence. The original content review remains incomplete.",
      "missingness": "Absence, influence, amounts, individual employment/patents, and writing/publication support have not been newly verified. Disclosures do not automatically invalidate results or certify independence.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Personal conflicts, support, and scale/analysis role material"
    },
    {
      "item_id": "N18",
      "question_type": "Evidence condition",
      "question": "Is the pediatric crossover trial direct replication of cream-use days?",
      "needed": "Children, crossover, 2 weeks, 42/40 participants, SCORAD, and different protocol",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Children, crossover, 2 weeks, 42/40 participants, SCORAD, and different protocol.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Children, crossover, 2 weeks, 42/40 participants, SCORAD, and different protocol. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M04 §4.6.1–4.6.2; distinction between studies and reports; cohort and outcome connections are Chamgap adaptations; M03 §3.2.1; detailed population conditions are Chamgap design; M08 §8.1–8.2.3; Chamgap adaptation; M04 §4.6.1–4.6.2, M15 §15.3.1; Chamgap adaptation",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Separate other populations, protocols, and crossover periods. This is a proposal; no new investigation, calculation, or trial was performed.",
      "current_reports": [
        "S02"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "Cardona’s original scope was a single-masked pediatric crossover trial allocating 42 people with 40 completers, over 2 weeks, with SCORAD primary.",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. Results with the same cream-use-day definition/comparison, crossover sequence/washout, and period-specific denominators are unverified. It is not counted as the same direct replication. The original content review remains incomplete.",
      "missingness": "Results with the same cream-use-day definition/comparison, crossover sequence/washout, and period-specific denominators are unverified. It is not counted as the same direct replication.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Pediatric methods, period-specific results, and treatment-behavior material"
    },
    {
      "item_id": "N19",
      "question_type": "Evidence condition",
      "question": "To which comparison does the pediatric soak-and-seal result belong?",
      "needed": "Historical frequency/duration, occlusive moisturization, and SCORAD scope",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Historical frequency/duration, occlusive moisturization, and SCORAD scope.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Historical frequency/duration, occlusive moisturization, and SCORAD scope. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M03 §3.2.2–3.2.3; reverse-direction marker and test adaptations are Chamgap design; M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are Chamgap design; M04 §4.6.1–4.6.2, M15 §15.3.1; Chamgap adaptation; M04 §4.6.3, M15 §15.3.1–15.3.3; separation of statuses is Chamgap design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Distinguish the earlier opposite-direction symptom result from selected use days. This is a proposal; no new investigation, calculation, or trial was performed.",
      "current_reports": [
        "S02"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "Historical pediatric conditions were twice daily for 15–20 minutes with immediate occlusive moisturization versus twice weekly for at most 10 minutes. The 21.2-point greater SCORAD reduction (CI 14.9 to 27.6), P<.0001, belongs to that comparison.",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. This different protocol is not reused as an effect on current cream-use-day reduction. No application/bathing implementation instructions or POEM/day conversions are created. The original content review remains incomplete.",
      "missingness": "This different protocol is not reused as an effect on current cream-use-day reduction. No application/bathing implementation instructions or POEM/day conversions are created.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Pediatric intervention/moisturization, scale, and treatment-behavior material"
    },
    {
      "item_id": "N20",
      "question_type": "Evidence condition",
      "question": "What remains unverified about pediatric identity, years, registration, and funding?",
      "needed": "Evidence-list 2019, citation 2020, original registration wording, and historical abstract support classification",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Evidence-list 2019, citation 2020, original registration wording, and historical abstract support classification.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Evidence-list 2019, citation 2020, original registration wording, and historical abstract support classification. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M04 §4.6.1–4.6.2; distinction between studies and reports; cohort and outcome connections are Chamgap adaptations; M04 §4.5, §4.6.3; limitations of this conversion follow the review scope and Chamgap design; Chamgap independence and attribution conditions; the official methodology sections used in this example do not certify all these detailed items; M08 Table 8.2.a, M04 §4.6.3; Chamgap adaptation",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Separate historical wording from actual material identity. This is a proposal; no new investigation, calculation, or trial was performed.",
      "current_reports": [
        "S02"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "Evidence-list year 2019, citation issue 2020/DOI 2019, registration field “could not confirm,” the historical classification “Research Support, Non-U.S. Gov't,” and unestablished supporting institution are preserved.",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. Publication stage and actual registration/institution/conflicts are unverified. Year differences do not add reports/trials, and “could not confirm” is not a registration identifier. The original content review remains incomplete.",
      "missingness": "Publication stage and actual registration/institution/conflicts are unverified. Year differences do not add reports/trials, and “could not confirm” is not a registration identifier.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original bibliographic/publication history and registration/funding material"
    },
    {
      "item_id": "N21",
      "question_type": "Evidence condition",
      "question": "Does the 13-study review concern the same secondary use-day result?",
      "needed": "Included exposures/designs, severity/treatment-behavior endpoints, and heterogeneity",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Included exposures/designs, severity/treatment-behavior endpoints, and heterogeneity.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Included exposures/designs, severity/treatment-behavior endpoints, and heterogeneity. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M04 §4.6.1–4.6.2; distinction between studies and reports; cohort and outcome connections are Chamgap adaptations; M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are Chamgap design; M04 §4.6.1–4.6.2, M15 §15.3.1; Chamgap adaptation; M04 §4.6.3, M15 §15.3.1–15.3.3; separation of statuses is Chamgap design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Separate the background review from the selected secondary behavior question. This is a proposal; no new investigation, calculation, or trial was performed.",
      "current_reports": [
        "S03"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "Hua’s review synthesized frequency/eczema severity from 13 prospective studies. Its original conclusion was that daily washing was not worse, but few heterogeneous studies left optimal frequency unclear.",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. The same cream-use-day analysis, included populations/treatments/protocols, overlap, and effect-specific denominators are unverified. Synthesized severity and use days are not treated as the same. The original content review remains incomplete.",
      "missingness": "The same cream-use-day analysis, included populations/treatments/protocols, overlap, and effect-specific denominators are unverified. Synthesized severity and use days are not treated as the same.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Included studies and endpoint/protocol-specific results"
    },
    {
      "item_id": "N22",
      "question_type": "Evidence condition",
      "question": "What are the historical review-year, support, and registration statements?",
      "needed": "Original 2020/citation 2021, unestablished funding, and not applicable",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Original 2020/citation 2021, unestablished funding, and not applicable.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Original 2020/citation 2021, unestablished funding, and not applicable. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M04 §4.5, §4.6.3; limitations of this conversion follow the review scope and Chamgap design; Chamgap independence and attribution conditions; the official methodology sections used in this example do not certify all these detailed items; M08 Table 8.2.a, M04 §4.6.3; Chamgap adaptation; M04 §4.5–4.6; material collection/selection principles; access/reading separation and hyperlink contract are Chamgap design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Distinguish original wording from the identity of newly supplied material. This is a proposal; no new investigation, calculation, or trial was performed.",
      "current_reports": [
        "S03"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "Evidence-list/manuscript 2020, citation issue 2021/DOI 2020, registration field “not applicable,” and unestablished specific funding are preserved.",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. Publication-stage differences, support/conflicts, and review plans/registration are unverified in this work. Not applicable or historical public checks are not converted into new verification of registration absence or reading. The original content review remains incomplete.",
      "missingness": "Publication-stage differences, support/conflicts, and review plans/registration are unverified in this work. Not applicable or historical public checks are not converted into new verification of registration absence or reading.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Bibliographic/publication history and review plans/support"
    },
    {
      "item_id": "N23",
      "question_type": "Harm-information gaps supplementing the efficacy table",
      "question": "What were the treatment-change-for-worsening and medical-advice results?",
      "needed": "Safety/behavior events, separate denominators, periods, and separation from cream-use days",
      "role": "Supplementary",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Safety/behavior events, separate denominators, periods, and separation from cream-use days.",
      "application_exception": "Addresses safety-material gaps for the selected subclaim. POEM, cream-use days, or parent safety wording do not establish safety or generate new harm incidence or instructions on bathing frequency/treatment behavior.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Safety/behavior events, separate denominators, periods, and separation from cream-use days. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M19 §19.1.2–19.2.4; Chamgap adaptation; M19 §19.1.2–19.2.4; detailed distinctions are Chamgap design; M19 §19.1.2–19.2.4; Chamgap adaptation; M19 §19.1.2–19.2.4, M04 §4.6.3; Chamgap adaptation",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Keep use days, treatment changes for worsening, and medical advice as distinct results. This is a proposal; no new investigation, calculation, or trial was performed.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "Treatment changes 17/165 (10.3%) versus 13/168 (7.7%) and medical advice 20/165 (12.1%) versus 13/170 (7.6%) are separate original results. Both were numerically higher with less-frequent washing.",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. They are not substituted as improvement/safety measures for cream-use days. Event definitions, overlap, missingness, and denominator correspondence are unverified; no new incidence or total is calculated. The original content review remains incomplete.",
      "missingness": "They are not substituted as improvement/safety measures for cream-use days. Event definitions, overlap, missingness, and denominator correspondence are unverified; no new incidence or total is calculated.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Event-specific safety/behavior definitions and denominator tables"
    },
    {
      "item_id": "N24",
      "question_type": "Harm-information gaps supplementing the efficacy table",
      "question": "What is the scope of unreported safety CI/P and causality?",
      "needed": "Between-arm testing, collection, baseline/concomitant treatment, discontinuation, and relatedness",
      "role": "Supplementary",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Between-arm testing, collection, baseline/concomitant treatment, discontinuation, and relatedness.",
      "application_exception": "Addresses safety-material gaps for the selected subclaim. POEM, cream-use days, or parent safety wording do not establish safety or generate new harm incidence or instructions on bathing frequency/treatment behavior.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Between-arm testing, collection, baseline/concomitant treatment, discontinuation, and relatedness. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M19 §19.1.2–19.2.4; Chamgap adaptation; M19 §19.2.2–19.2.4, M03 §3.2.3; Chamgap adaptation; M19 §19.2.2–19.2.4; design considerations; detailed confounding records are Chamgap design; Chamgap interpretation boundary; M19 is a reference principle, not execution of an official causality tool",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Separate actual reporting levels for efficacy/behavior and harms. This is a proposal; no new investigation, calculation, or trial was performed.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "The manuscript records that significant worsening cannot be concluded because between-arm CI/P values for the two safety outcomes were not reported.",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. The complete external full text was not read in this work. Numerical direction is not converted into significant worsening, causality, or safety confirmation, and no new CI/P is calculated. The original content review remains incomplete.",
      "missingness": "The complete external full text was not read in this work. Numerical direction is not converted into significant worsening, causality, or safety confirmation, and no new CI/P is calculated.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Safety analysis/collection and relatedness/concomitant treatment material"
    },
    {
      "item_id": "N25",
      "question_type": "Evidence condition",
      "question": "How are the same reports, populations, and related sheets shared?",
      "needed": "Online trial, pediatric crossover, review, and report/replication relationships",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Online trial, pediatric crossover, review, and report/replication relationships.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Online trial, pediatric crossover, review, and report/replication relationships. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "Study/report distinction in M04 §4.6.1–4.6.2; Cohort/outcome linkage is Chamgap application; M04 §4.6.1–4.6.2 and M15 §15.3.1; Chamgap application",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Separate unrecorded unique clinical totals from report/material entries. This is a proposal; no new investigation, calculation, or trial was performed.",
      "current_reports": [
        "S01",
        "S02",
        "S03"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "The existing two selected sheets share the same stored summary, direct trial, and context reports. Pediatric crossover periods, the same 42/40 participants, and the 13-study review are not summed as separate independent totals.",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. Review inclusion, related/follow-up report identity, and overlap have not been externally compared. Report counts and original R0/I2 do not newly certify independent replication. The original content review remains incomplete.",
      "missingness": "Review inclusion, related/follow-up report identity, and overlap have not been externally compared. Report counts and original R0/I2 do not newly certify independent replication.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Registration and included/related report tables"
    },
    {
      "item_id": "N26",
      "question_type": "Harm-information gaps supplementing the efficacy table",
      "question": "Is the selected result extended to optimal frequency, long-term outcomes, or other products?",
      "needed": "Direct evidence for 4 weeks/population, environments, separate products, and treatment behavior",
      "role": "Supplementary",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Direct evidence for 4 weeks/population, environments, separate products, and treatment behavior.",
      "application_exception": "Addresses safety-material gaps for the selected subclaim. POEM, cream-use days, or parent safety wording do not establish safety or generate new harm incidence or instructions on bathing frequency/treatment behavior.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Direct evidence for 4 weeks/population, environments, separate products, and treatment behavior. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M03 §3.2.1–3.2.4; dose, duration and effect-modification details are Chamgap design; M03 §3.2.4; Chamgap extrapolation boundary; M19 §19.1.2–19.2.4; Chamgap adaptation; M19 §19.1.2–19.2.4; Chamgap adaptation",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Separate other products, environments, and long-term questions from the current secondary result. This is a proposal; no new investigation, calculation, or trial was performed.",
      "current_reports": [
        "S01",
        "S02",
        "S03"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "The manuscript links to bath additives 2887/water softeners 2426 as separate verdicts, not additional trials. Hot/humid environments, high infection risk, and beyond 4 weeks are scopes to which it did not generalize.",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. Direct material on long-term cream use, other environments/populations, and products was not retrieved in this work. No instructions on washing frequency, reducing/stopping treatment, or implementing treatment are created. The original content review remains incomplete.",
      "missingness": "Direct material on long-term cream use, other environments/populations, and products was not retrieved in this work. No instructions on washing frequency, reducing/stopping treatment, or implementing treatment are created.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Material on separate populations/durations and related exposures"
    },
    {
      "item_id": "N27",
      "question_type": "Evidence condition",
      "question": "What history do parent D30, languages, dates, empty values, and corrections represent?",
      "needed": "Selected C/parent D30, original axes, Korean/English manuscript, and cross-checks/corrections",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Selected C/parent D30, original axes, Korean/English manuscript, and cross-checks/corrections.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Selected C/parent D30, original axes, Korean/English manuscript, and cross-checks/corrections. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M04 §4.5, §4.6.3; current material-conversion limits reflect review scope and our own design; M04 §4.6.3, M15 §15.3.1–15.3.3; status distinctions are our own design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Distinguish the original record from production and amendment events. This is a proposal; no new investigation, calculation or trial was performed.",
      "current_reports": [
        "S01",
        "S02",
        "S03"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "Parent D30, original axis C0, false flags and empty grade-override reasons, the bilingual manuscript, 2026-08-26, the empty correction array and empty deliberation string, historical cross-checks, original wording, and year differences are preserved in the complete stored summary.",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. Parent D/score/axes are not reused as values of selected C. Original wording/typos were not automatically corrected, and no current search, original-language review, or correction check was performed. The original content review remains incomplete.",
      "missingness": "Parent D/score/axes are not reused as values of selected C. Original wording/typos were not automatically corrected, and no current search, original-language review, or correction check was performed.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Correction records and user feedback"
    },
    {
      "item_id": "N28",
      "question_type": "Evidence condition",
      "question": "What is the reading level of summaries and external papers/plans/disclosures?",
      "needed": "Material types, actual acquisition/reading, and original links",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Material types, actual acquisition/reading, and original links.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Material types, actual acquisition/reading, and original links. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M04 §4.5–4.6 material collection/selection principles; acquisition/reading separation and hyperlink specifications are internally designed; M04 §4.5, §4.6.3; limits of this material conversion follow the review scope and internal design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Update material-specific existence, acquisition, actual reading, and access history separately. This is a proposal; no new investigation, calculation, or trial was performed.",
      "current_reports": [
        "S01",
        "S02",
        "S03"
      ],
      "existence": "Stored summary/bibliography links; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "observation": "The complete stored summary and 3 evidence entries/3 citations were read for production and original source links connected. Summaries are marked “summary read” and external material “unread.”",
      "condition_status": "Partly verified",
      "status_reason": "Only the corresponding stored-summary information is recorded; detailed original material remains unread and the original content review incomplete. External abstracts/full texts, registration/protocols/statistical analysis plans, and disclosures remain unread; access was not attempted. Historical public checks and link existence are not inherited as acquisition, full-text reading, or review in this work. The original content review remains incomplete.",
      "missingness": "External abstracts/full texts, registration/protocols/statistical analysis plans, and disclosures remain unread; access was not attempted. Historical public checks and link existence are not inherited as acquisition, full-text reading, or review in this work.",
      "uncertainty": "This record links preserved-summary statements; it does not establish external-paper comparison, a new efficacy verdict or completed content review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original material and actual reading history for each report"
    }
  ],
  "reports": [
    {
      "report_id": "S01",
      "title": "Bradshaw L et al. 2026 Eczema Bathing Study",
      "url": "https://pubmed.ncbi.nlm.nih.gov/41208015/",
      "report_type": "UK-wide online pragmatic parallel-group randomized superiority trial",
      "existence": "Stored bibliography exists; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "study_family": "RG2947-ECZEMA-BATHING",
      "independent_replication": null,
      "observed_result": "Mean use of 0.5 fewer days per week (95% CI −0.8 to −0.1) in the once-or-twice-weekly arm is preserved. The original English manuscript describes an adjusted mean. Arm-specific means, adjusted models, denominators, P values, and collection definitions are unverified; no new days, doses, differences, or confidence intervals are calculated. Mean POEM, responders, and the two safety outcomes have separate values, denominators, and hierarchies.",
      "result_level": "Outcome wording in the stored summary",
      "source_evidence_date": "2026-08-26",
      "materials": [
        {
          "material_type": "Stored summary",
          "public_status": "Stored file",
          "access_status": "Stored summary",
          "acquired": true,
          "actually_read": "Summary read",
          "as_of": "2026-08-26",
          "qualification": "Only stored-summary and bibliographic content was used for production. External material verification/review is not complete."
        },
        {
          "material_type": "External paper",
          "public_status": "Public availability unverified; only bibliography links preserved",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-08-26",
          "qualification": "No external access or click testing was performed in the original preparation. URLs or registration identifiers alone do not upgrade acquisition/reading status."
        },
        {
          "material_type": "Registration material",
          "public_status": "Public availability unverified; only bibliography links preserved",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-08-26",
          "qualification": "No external access or click testing was performed in the original preparation. URLs or registration identifiers alone do not upgrade acquisition/reading status."
        },
        {
          "material_type": "Protocol",
          "public_status": "Public availability unverified; only bibliography links preserved",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-08-26",
          "qualification": "No external access or click testing was performed in the original preparation. URLs or registration identifiers alone do not upgrade acquisition/reading status."
        },
        {
          "material_type": "Statistical analysis plan",
          "public_status": "Public availability unverified; only bibliography links preserved",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-08-26",
          "qualification": "No external access or click testing was performed in the original preparation. URLs or registration identifiers alone do not upgrade acquisition/reading status."
        },
        {
          "material_type": "Funding, product-support and COI material",
          "public_status": "Public availability unverified; only bibliography links preserved",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-08-26",
          "qualification": "No external access or click testing was performed in the original preparation. URLs or registration identifiers alone do not upgrade acquisition/reading status."
        }
      ],
      "links": [
        {
          "label": "PubMed",
          "url": "https://pubmed.ncbi.nlm.nih.gov/41208015/"
        }
      ]
    },
    {
      "report_id": "S02",
      "title": "Cardona ID et al. 2019 pediatric soak-and-seal trial",
      "url": "https://pubmed.ncbi.nlm.nih.gov/31733336/",
      "report_type": "Pediatric randomized single-masked crossover trial",
      "existence": "Stored bibliography exists; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "study_family": "RG2947-CARDONA-PEDIATRIC-CROSSOVER",
      "independent_replication": null,
      "observed_result": "In the historical study, twice-daily 15–20-minute soak-and-seal produced a 21.2-point greater SCORAD reduction than twice-weekly bathing for at most 10 minutes (95% CI 14.9 to 27.6), P<0.0001. These values belong to a different protocol/scale and are not converted into POEM points, response rates, or cream-use days. Unverified registration, abstract support classification with supporting institution unestablished, and evidence-list/citation year differences are preserved and not backdated as external verification in this work.",
      "result_level": "Outcome wording in the stored summary",
      "source_evidence_date": "2026-08-26",
      "materials": [
        {
          "material_type": "Stored summary",
          "public_status": "Stored file",
          "access_status": "Stored summary",
          "acquired": true,
          "actually_read": "Summary read",
          "as_of": "2026-08-26",
          "qualification": "Only stored-summary and bibliographic content was used for production. External material verification/review is not complete."
        },
        {
          "material_type": "External paper",
          "public_status": "Public availability unverified; only bibliography links preserved",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-08-26",
          "qualification": "No external access or click testing was performed in the original preparation. URLs or registration identifiers alone do not upgrade acquisition/reading status."
        },
        {
          "material_type": "Registration material",
          "public_status": "Public availability unverified; only bibliography links preserved",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-08-26",
          "qualification": "No external access or click testing was performed in the original preparation. URLs or registration identifiers alone do not upgrade acquisition/reading status."
        },
        {
          "material_type": "Protocol",
          "public_status": "Public availability unverified; only bibliography links preserved",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-08-26",
          "qualification": "No external access or click testing was performed in the original preparation. URLs or registration identifiers alone do not upgrade acquisition/reading status."
        },
        {
          "material_type": "Statistical analysis plan",
          "public_status": "Public availability unverified; only bibliography links preserved",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-08-26",
          "qualification": "No external access or click testing was performed in the original preparation. URLs or registration identifiers alone do not upgrade acquisition/reading status."
        },
        {
          "material_type": "Funding, product-support and COI material",
          "public_status": "Public availability unverified; only bibliography links preserved",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-08-26",
          "qualification": "No external access or click testing was performed in the original preparation. URLs or registration identifiers alone do not upgrade acquisition/reading status."
        }
      ],
      "links": [
        {
          "label": "PubMed",
          "url": "https://pubmed.ncbi.nlm.nih.gov/31733336/"
        }
      ]
    },
    {
      "report_id": "S03",
      "title": "Hua T et al. 2020 systematic review and meta-analysis",
      "url": "https://pubmed.ncbi.nlm.nih.gov/33196889/",
      "report_type": "Systematic review and meta-analysis of bathing/showering frequency studies",
      "existence": "Stored bibliography exists; external identity unverified",
      "acquired_read": "Summary read; external material unread",
      "study_family": "SYN2947-HUA-FREQUENCY-REVIEW",
      "independent_replication": null,
      "observed_result": "The original conclusion was that daily washing was not associated with worse severity, but studies were few and heterogeneous, leaving optimal frequency unclear. This does not verify optimal frequency, all safety, or the selected responder/use-day effects. Gaps in included studies, endpoint-specific values, review support/conflicts/plans, and original year differences are retained.",
      "result_level": "Outcome wording in the stored summary",
      "source_evidence_date": "2026-08-26",
      "materials": [
        {
          "material_type": "Stored summary",
          "public_status": "Stored file",
          "access_status": "Stored summary",
          "acquired": true,
          "actually_read": "Summary read",
          "as_of": "2026-08-26",
          "qualification": "Only stored-summary and bibliographic content was used for production. External material verification/review is not complete."
        },
        {
          "material_type": "External paper",
          "public_status": "Public availability unverified; only bibliography links preserved",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-08-26",
          "qualification": "No external access or click testing was performed in the original preparation. URLs or registration identifiers alone do not upgrade acquisition/reading status."
        },
        {
          "material_type": "Registration material",
          "public_status": "Public availability unverified; only bibliography links preserved",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-08-26",
          "qualification": "No external access or click testing was performed in the original preparation. URLs or registration identifiers alone do not upgrade acquisition/reading status."
        },
        {
          "material_type": "Protocol",
          "public_status": "Public availability unverified; only bibliography links preserved",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-08-26",
          "qualification": "No external access or click testing was performed in the original preparation. URLs or registration identifiers alone do not upgrade acquisition/reading status."
        },
        {
          "material_type": "Statistical analysis plan",
          "public_status": "Public availability unverified; only bibliography links preserved",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-08-26",
          "qualification": "No external access or click testing was performed in the original preparation. URLs or registration identifiers alone do not upgrade acquisition/reading status."
        },
        {
          "material_type": "Funding, product-support and COI material",
          "public_status": "Public availability unverified; only bibliography links preserved",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-08-26",
          "qualification": "No external access or click testing was performed in the original preparation. URLs or registration identifiers alone do not upgrade acquisition/reading status."
        }
      ],
      "links": [
        {
          "label": "PubMed",
          "url": "https://pubmed.ncbi.nlm.nih.gov/33196889/"
        }
      ]
    }
  ],
  "method_sources": [
    {
      "id": "M03",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03",
      "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13",
      "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.",
      "review_level": "Preserved method HTML copies; no current method-content re-review or official tool execution"
    },
    {
      "id": "M04",
      "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04",
      "section": "§4.5, §4.6.1–4.6.3, MECIR C42",
      "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.",
      "review_level": "Preserved method HTML copies; no current method-content re-review or official tool execution"
    },
    {
      "id": "M08",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08",
      "section": "§8.1–8.2.3, Table 8.2.a",
      "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.",
      "review_level": "Preserved method HTML copies; no current method-content re-review or official tool execution"
    },
    {
      "id": "M15",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15",
      "section": "§15.2.4, §15.3.1–15.3.3",
      "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.",
      "review_level": "Preserved method HTML copies; no current method-content re-review or official tool execution"
    },
    {
      "id": "M19",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19",
      "section": "§19.1.2, §19.2.1–19.2.4",
      "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.",
      "review_level": "Preserved method HTML copies; no current method-content re-review or official tool execution"
    }
  ],
  "status_dictionary": {
    "Met": "Status for necessary evidence confirmed after existing content review. No completion is declared in the current presentation.",
    "Partly verified": "Some information in the stored summary is linked into the table. External comparison/content review is not complete.",
    "Unverified": "The article leaves this unverified, or required material is absent from the current stored summary. This is distinct from zero, absence or safety.",
    "Review incomplete": "Existing content review remains incomplete.",
    "Not reported": "Not reported within the stored material actually read; not extended to the entire primary paper.",
    "Inaccessible": "Means an actual access failure. Access not attempted here is not assigned this state.",
    "Not applicable": "Not used as a substitute for an evidence gap.",
    "Conflicting data": "Requires an observed disagreement under the same comparison criteria; not automatically judged in this production.",
    "Insufficient evidence for the conditions": "Marks a gap in additional material required by the selected conditions; not a new efficacy grade."
  },
  "study_overlap": {
    "state": "Unverified",
    "unique_trial_count": null,
    "unique_participant_count": null,
    "reason": "The UK online Eczema Bathing Study and ISRCTN12016473 describe a parallel-group superiority trial of 438 people (220/218), aged at least 1 year with POEM scores of at least 3, comparing once or twice weekly with at least six times weekly for 4 weeks. Both arms continued usual moisturizers/topical treatment, participant masking was impossible, and the primary model contained 388 people (193/195). Week-4 responders 169/171, the unverified cream-use-day denominator, and safety-specific denominators 165/168/170 are distinct. The same trial, reports, participants, arms, weeks, and selected sheets sharing the same material are not summed as independent trials/participants. Report/material entries are not totals of unique clinical trials, participants, or independent replications; unique totals remain unrecorded. Cardona’s pediatric single-masked crossover trial preserves the evidence-list year 2019 separately from the citation’s 2020 issue and 2019 DOI. Its 42 allocated participants, 40 completers, 2 weeks, primary SCORAD, and combined bathing frequency/duration with immediate moisturization describe a different protocol. It is not direct replication of the current comparison, POEM responders, or cream-use days. Crossover periods, sequence, washout, publication stage, funding, and registration details are unverified. Selected sheets sharing material and report/material entries are not summed as unique trials, participants, or independent replications; unique totals remain unrecorded. Hua’s synthesis of 13 prospective studies preserves evidence-list/manuscript 2020 separately from citation issue 2021 and DOI 2020. Its original conclusion of few, heterogeneous protocols, eczema severity, and unclear optimal frequency is retained. Included/related trial overlap, population/endpoint denominators, and publication stages remain unverified; it is not counted as independent RCT, responder, or cream-use-day replication. Selected sheets sharing material and report/material entries are not summed as unique trials, participants, or independent replications; unique totals remain unrecorded."
  },
  "history": [
    {
      "date": "2026-10-11",
      "kind": "Separation of public-facing pages and materials",
      "view_version": "1.0",
      "change": "Public reader pages and material were prepared from the existing 28 items. No new clinical searches, verification-state changes or scoring were performed."
    }
  ],
  "language": "en",
  "translation_date": "2026-10-11"
}