{
  "schema_version": "chamgap-public-criteria-1.0",
  "title": "Reduced bathing/showering frequency × weekly flare-control cream-use days: evidence checklist",
  "language": "en",
  "translation_date": "2026-10-11",
  "criteria_version": "1.0",
  "criteria_date": "2026-10-06",
  "condition_origin": "Chamgap's own application conditions",
  "method_sources": [
    {
      "id": "M03",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03",
      "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13",
      "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.",
      "review_level": "Preserved method HTML copies; no current method-content re-review or official tool execution"
    },
    {
      "id": "M04",
      "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04",
      "section": "§4.5, §4.6.1–4.6.3, MECIR C42",
      "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.",
      "review_level": "Preserved method HTML copies; no current method-content re-review or official tool execution"
    },
    {
      "id": "M08",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08",
      "section": "§8.1–8.2.3, Table 8.2.a",
      "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.",
      "review_level": "Preserved method HTML copies; no current method-content re-review or official tool execution"
    },
    {
      "id": "M15",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15",
      "section": "§15.2.4, §15.3.1–15.3.3",
      "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.",
      "review_level": "Preserved method HTML copies; no current method-content re-review or official tool execution"
    },
    {
      "id": "M19",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19",
      "section": "§19.1.2, §19.2.1–19.2.4",
      "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.",
      "review_level": "Preserved method HTML copies; no current method-content re-review or official tool execution"
    }
  ],
  "status_dictionary": {
    "Met": "Status for necessary evidence confirmed after existing content review. No completion is declared in the current presentation.",
    "Partly verified": "Some information in the stored summary is linked into the table. External comparison/content review is not complete.",
    "Unverified": "The article leaves this unverified, or required material is absent from the current stored summary. This is distinct from zero, absence or safety.",
    "Review incomplete": "Existing content review remains incomplete.",
    "Not reported": "Not reported within the stored material actually read; not extended to the entire primary paper.",
    "Inaccessible": "Means an actual access failure. Access not attempted here is not assigned this state.",
    "Not applicable": "Not used as a substitute for an evidence gap.",
    "Conflicting data": "Requires an observed disagreement under the same comparison criteria; not automatically judged in this production.",
    "Insufficient evidence for the conditions": "Marks a gap in additional material required by the selected conditions; not a new efficacy grade."
  },
  "requirements": [
    {
      "item_id": "N01",
      "question_type": "Evidence condition",
      "question": "Which existing cream-use-day question and verdict are preserved?",
      "needed": "Separation of the selected C grade/note from parent D30 and other subclaims",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Separation of the selected C grade/note from parent D30 and other subclaims.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Separation of the selected C grade/note from parent D30 and other subclaims. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M03 §3.1, §3.2.1–3.2.4 question-clarification principles; detailed separation rules are internally designed; M04 §4.5, §4.6.3; limits of this material conversion follow the review scope and internal design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Update the question, assessment record and assessment context separately. This is a proposal; no new investigation, calculation or trial was performed."
    },
    {
      "item_id": "N02",
      "question_type": "Evidence condition",
      "question": "Who were the actual population, recruits, and respondents?",
      "needed": "Age at least 1 year, POEM criterion, online recruitment, baseline, and proxy responses",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Age at least 1 year, POEM criterion, online recruitment, baseline, and proxy responses.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Age at least 1 year, POEM criterion, online recruitment, baseline, and proxy responses. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M03 §3.2.1; detailed population conditions are Chamgap design; M08 Table 8.2.a, M03 §3.2.4; Chamgap adaptation",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Record baseline use and representativeness of the selected population within the material scope. This is a proposal; no new investigation, calculation, or trial was performed."
    },
    {
      "item_id": "N03",
      "question_type": "Evidence condition",
      "question": "How did assigned frequency differ from actual exposure?",
      "needed": "Once or twice weekly/at least six times weekly, 4 weeks, actual adherence, and changes",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Once or twice weekly/at least six times weekly, 4 weeks, actual adherence, and changes.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Once or twice weekly/at least six times weekly, 4 weeks, actual adherence, and changes. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M03 §3.2.2–3.2.3; Reverse-direction labels and assessment adaptation are Chamgap design; M03 §3.2.3 and M08 §8.2.2–8.2.3; Chamgap application",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Distinguish material on nominal assignment from actual exposure. This is a proposal; no new investigation, calculation, or trial was performed."
    },
    {
      "item_id": "N04",
      "question_type": "Evidence condition",
      "question": "How did common topical treatment relate to the cream endpoint?",
      "needed": "Moisturizers, usual topical treatment, selected use days, and arm-specific changes",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Moisturizers, usual topical treatment, selected use days, and arm-specific changes.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Moisturizers, usual topical treatment, selected use days, and arm-specific changes. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M03 §3.2.3, M08 §8.2.2–8.2.3; own application; M03 §3.2.2–3.2.3; reverse-direction labels and test adaptations are our own design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Distinguish frequency effects from concomitant treatment/treatment behavior. This is a proposal; no new investigation, calculation, or trial was performed."
    },
    {
      "item_id": "N05",
      "question_type": "Evidence condition",
      "question": "Which question did trial design and allocation assess?",
      "needed": "Online parallel groups, superiority, allocation/concealment, and baseline balance",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Online parallel groups, superiority, allocation/concealment, and baseline balance.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Online parallel groups, superiority, allocation/concealment, and baseline balance. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M08 §8.1–8.2.3; Chamgap adaptation; M08 Table 8.2.a, M04 §4.6.3; Chamgap adaptation",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Separate the overall design from the analysis specification of the selected secondary result. This is a proposal; no new investigation, calculation, or trial was performed."
    },
    {
      "item_id": "N06",
      "question_type": "Evidence condition",
      "question": "What limits arise from impossible masking and use-day recording?",
      "needed": "Recorder, collection method, and participant/assessor/analyst masking",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Recorder, collection method, and participant/assessor/analyst masking.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Recorder, collection method, and participant/assessor/analyst masking. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M08 Table 8.2.a, M03 §3.2.4; internal application",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Record actual limits of treatment behavior and measurement. This is a proposal; no new investigation, calculation, or trial was performed."
    },
    {
      "item_id": "N07",
      "question_type": "Evidence condition",
      "question": "What unit is a day of flare-control cream use?",
      "needed": "Cream definition, classification of a use day, days per week, and observation period",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Cream definition, classification of a use day, days per week, and observation period.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Cream definition, classification of a use day, days per week, and observation period. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are our own design; M08 Table 8.2.a, M03 §3.2.4; our own application",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Preserve the units and period of the treatment-behavior endpoint. This is a proposal; no new investigation, calculation, or trial was performed."
    },
    {
      "item_id": "N08",
      "question_type": "Evidence condition",
      "question": "What were the original mean use-day difference and interval?",
      "needed": "Arm correspondence, adjustment, direction, and original CI",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Arm correspondence, adjustment, direction, and original CI.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Arm correspondence, adjustment, direction, and original CI. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M08 §8.2.2, M15 §15.3.1; Chamgap application; M15 §15.3.1–15.3.3; Chamgap application; M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; design-specific adaptations are Chamgap's own design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Connect the original difference, direction, and interval with that secondary analysis. This is a proposal; no new investigation, calculation, or trial was performed."
    },
    {
      "item_id": "N09",
      "question_type": "Evidence condition",
      "question": "What is the level of secondary-result hierarchy and multiplicity?",
      "needed": "Prespecified secondary definition, testing hypotheses, multiple comparisons, and changes",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Prespecified secondary definition, testing hypotheses, multiple comparisons, and changes.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Prespecified secondary definition, testing hypotheses, multiple comparisons, and changes. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M08 Table 8.2.a, M04 §4.6.3; Chamgap adaptation; M15 §15.3.1–15.3.3; Chamgap adaptation",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Distinguish material on primary/secondary results from selective reporting/plans. This is a proposal; no new investigation, calculation, or trial was performed."
    },
    {
      "item_id": "N10",
      "question_type": "Evidence condition",
      "question": "Do fewer use days mean symptom benefit or reduced worsening?",
      "needed": "Behavior endpoint, symptoms, worsening/harms, and interpretation scope",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Behavior endpoint, symptoms, worsening/harms, and interpretation scope.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Behavior endpoint, symptoms, worsening/harms, and interpretation scope. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M04 §4.6.3, M15 §15.3.1–15.3.3; separation of statuses is Chamgap design; M03 §3.2.4; Chamgap extrapolation boundary; M15 §15.3.1–15.3.3; Chamgap adaptation",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Record behavior change separately from patient outcomes. This is a proposal; no new investigation, calculation, or trial was performed."
    },
    {
      "item_id": "N11",
      "question_type": "Evidence condition",
      "question": "What separate results are primary mean POEM and the 2.2-point assumption?",
      "needed": "Four-week mean, scale, original CI/P, and power assumption",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Four-week mean, scale, original CI/P, and power assumption.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Four-week mean, scale, original CI/P, and power assumption. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are Chamgap design; M15 §15.3.1–15.3.3; Chamgap adaptation; M04 §4.6.3, M15 §15.3.1–15.3.3; separation of statuses is Chamgap design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Keep continuous symptoms and treatment-use days separate. This is a proposal; no new investigation, calculation, or trial was performed."
    },
    {
      "item_id": "N12",
      "question_type": "Evidence condition",
      "question": "Are 3-point responders mixed with reduced cream use?",
      "needed": "Threshold response, counts/denominators, original RD/RR, and use-day differences",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Threshold response, counts/denominators, original RD/RR, and use-day differences.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Threshold response, counts/denominators, original RD/RR, and use-day differences. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are Chamgap design; M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; design-specific adaptations are Chamgap design; M04 §4.6.3, M15 §15.3.1–15.3.3; separation of statuses is Chamgap design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Record the different units/questions of responders and use days. This is a proposal; no new investigation, calculation, or trial was performed."
    },
    {
      "item_id": "N13",
      "question_type": "Evidence condition",
      "question": "What were the cream-use-day analysis denominator and missingness?",
      "needed": "Allocation, recording, completion, analysis, and weekly/week-4 denominators",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Allocation, recording, completion, analysis, and weekly/week-4 denominators.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Allocation, recording, completion, analysis, and weekly/week-4 denominators. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M08 Table 8.2.a, M15 §15.3 and M19 §19.1.2–19.2.4; Design-specific adaptation is Chamgap design; M08 §8.2.2 and M15 §15.3.1; Chamgap application",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Link recorder/time-specific denominators separately if material is supplied. This is a proposal; no new investigation, calculation, or trial was performed."
    },
    {
      "item_id": "N14",
      "question_type": "Evidence condition",
      "question": "Were analysis populations, adjustment, and sensitivity verified for cream?",
      "needed": "Effect of interest, ITT/PP, model, and missingness/sensitivity scope",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Effect of interest, ITT/PP, model, and missingness/sensitivity scope.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Effect of interest, ITT/PP, model, and missingness/sensitivity scope. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M08 §8.2.2 and M15 §15.3.1: in-house application; M08 Table 8.2.a, M15 §15.3 and M19 §19.1.2–19.2.4: design-specific adaptation is in-house.",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Distinguish endpoint-specific analysis from the general narrative. This is a proposal; no new investigation, calculation, or trial was performed."
    },
    {
      "item_id": "N15",
      "question_type": "Evidence condition",
      "question": "Were registration, plans, and changes actually compared?",
      "needed": "ISRCTN, prespecified cream definition, primary/secondary plans, and statistical analysis plan",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: ISRCTN, prespecified cream definition, primary/secondary plans, and statistical analysis plan.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: ISRCTN, prespecified cream definition, primary/secondary plans, and statistical analysis plan. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M08 Table 8.2.a, M04 §4.6.3; Chamgap application; M04 §4.5–4.6 principles for collecting and selecting materials; separation of access and reading and hyperlink rules are Chamgap's own design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Separate prespecification, actual reporting, changes, and the level of supplied material. This is a proposal; no new investigation, calculation, or trial was performed."
    },
    {
      "item_id": "N16",
      "question_type": "Evidence condition",
      "question": "What was declared about NIHR support and noninvolvement?",
      "needed": "Funding programme/identifier, roles, and actual verification scope",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Funding programme/identifier, roles, and actual verification scope.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Funding programme/identifier, roles, and actual verification scope. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "Chamgap's own conditions for independence and attribution. The official methodological sections used in this example do not validate every detail of these items.",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Separate support and declared noninvolvement from actual verification level. This is a proposal; no new investigation, calculation, or trial was performed."
    },
    {
      "item_id": "N17",
      "question_type": "Evidence condition",
      "question": "What is the scope of unreported commercial supply and personal conflicts?",
      "needed": "Products/devices/placebos, analysis services, personal consultancy, and scale development",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Products/devices/placebos, analysis services, personal consultancy, and scale development.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Products/devices/placebos, analysis services, personal consultancy, and scale development. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "Chamgap independence and attribution conditions; the official methodology sections used in this example do not certify all these detailed items; M08 Table 8.2.a, M03 §3.2.4; Chamgap adaptation",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Separate disclosed items from actual trial/result roles. This is a proposal; no new investigation, calculation, or trial was performed."
    },
    {
      "item_id": "N18",
      "question_type": "Evidence condition",
      "question": "Is the pediatric crossover trial direct replication of cream-use days?",
      "needed": "Children, crossover, 2 weeks, 42/40 participants, SCORAD, and different protocol",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Children, crossover, 2 weeks, 42/40 participants, SCORAD, and different protocol.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Children, crossover, 2 weeks, 42/40 participants, SCORAD, and different protocol. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M04 §4.6.1–4.6.2; distinction between studies and reports; cohort and outcome connections are Chamgap adaptations; M03 §3.2.1; detailed population conditions are Chamgap design; M08 §8.1–8.2.3; Chamgap adaptation; M04 §4.6.1–4.6.2, M15 §15.3.1; Chamgap adaptation",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Separate other populations, protocols, and crossover periods. This is a proposal; no new investigation, calculation, or trial was performed."
    },
    {
      "item_id": "N19",
      "question_type": "Evidence condition",
      "question": "To which comparison does the pediatric soak-and-seal result belong?",
      "needed": "Historical frequency/duration, occlusive moisturization, and SCORAD scope",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Historical frequency/duration, occlusive moisturization, and SCORAD scope.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Historical frequency/duration, occlusive moisturization, and SCORAD scope. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M03 §3.2.2–3.2.3; reverse-direction marker and test adaptations are Chamgap design; M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are Chamgap design; M04 §4.6.1–4.6.2, M15 §15.3.1; Chamgap adaptation; M04 §4.6.3, M15 §15.3.1–15.3.3; separation of statuses is Chamgap design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Distinguish the earlier opposite-direction symptom result from selected use days. This is a proposal; no new investigation, calculation, or trial was performed."
    },
    {
      "item_id": "N20",
      "question_type": "Evidence condition",
      "question": "What remains unverified about pediatric identity, years, registration, and funding?",
      "needed": "Evidence-list 2019, citation 2020, original registration wording, and historical abstract support classification",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Evidence-list 2019, citation 2020, original registration wording, and historical abstract support classification.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Evidence-list 2019, citation 2020, original registration wording, and historical abstract support classification. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M04 §4.6.1–4.6.2; distinction between studies and reports; cohort and outcome connections are Chamgap adaptations; M04 §4.5, §4.6.3; limitations of this conversion follow the review scope and Chamgap design; Chamgap independence and attribution conditions; the official methodology sections used in this example do not certify all these detailed items; M08 Table 8.2.a, M04 §4.6.3; Chamgap adaptation",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Separate historical wording from actual material identity. This is a proposal; no new investigation, calculation, or trial was performed."
    },
    {
      "item_id": "N21",
      "question_type": "Evidence condition",
      "question": "Does the 13-study review concern the same secondary use-day result?",
      "needed": "Included exposures/designs, severity/treatment-behavior endpoints, and heterogeneity",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Included exposures/designs, severity/treatment-behavior endpoints, and heterogeneity.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Included exposures/designs, severity/treatment-behavior endpoints, and heterogeneity. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M04 §4.6.1–4.6.2; distinction between studies and reports; cohort and outcome connections are Chamgap adaptations; M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are Chamgap design; M04 §4.6.1–4.6.2, M15 §15.3.1; Chamgap adaptation; M04 §4.6.3, M15 §15.3.1–15.3.3; separation of statuses is Chamgap design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Separate the background review from the selected secondary behavior question. This is a proposal; no new investigation, calculation, or trial was performed."
    },
    {
      "item_id": "N22",
      "question_type": "Evidence condition",
      "question": "What are the historical review-year, support, and registration statements?",
      "needed": "Original 2020/citation 2021, unestablished funding, and not applicable",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Original 2020/citation 2021, unestablished funding, and not applicable.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Original 2020/citation 2021, unestablished funding, and not applicable. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M04 §4.5, §4.6.3; limitations of this conversion follow the review scope and Chamgap design; Chamgap independence and attribution conditions; the official methodology sections used in this example do not certify all these detailed items; M08 Table 8.2.a, M04 §4.6.3; Chamgap adaptation; M04 §4.5–4.6; material collection/selection principles; access/reading separation and hyperlink contract are Chamgap design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Distinguish original wording from the identity of newly supplied material. This is a proposal; no new investigation, calculation, or trial was performed."
    },
    {
      "item_id": "N23",
      "question_type": "Harm-information gaps supplementing the efficacy table",
      "question": "What were the treatment-change-for-worsening and medical-advice results?",
      "needed": "Safety/behavior events, separate denominators, periods, and separation from cream-use days",
      "role": "Supplementary",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Safety/behavior events, separate denominators, periods, and separation from cream-use days.",
      "application_exception": "Addresses safety-material gaps for the selected subclaim. POEM, cream-use days, or parent safety wording do not establish safety or generate new harm incidence or instructions on bathing frequency/treatment behavior.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Safety/behavior events, separate denominators, periods, and separation from cream-use days. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M19 §19.1.2–19.2.4; Chamgap adaptation; M19 §19.1.2–19.2.4; detailed distinctions are Chamgap design; M19 §19.1.2–19.2.4; Chamgap adaptation; M19 §19.1.2–19.2.4, M04 §4.6.3; Chamgap adaptation",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Keep use days, treatment changes for worsening, and medical advice as distinct results. This is a proposal; no new investigation, calculation, or trial was performed."
    },
    {
      "item_id": "N24",
      "question_type": "Harm-information gaps supplementing the efficacy table",
      "question": "What is the scope of unreported safety CI/P and causality?",
      "needed": "Between-arm testing, collection, baseline/concomitant treatment, discontinuation, and relatedness",
      "role": "Supplementary",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Between-arm testing, collection, baseline/concomitant treatment, discontinuation, and relatedness.",
      "application_exception": "Addresses safety-material gaps for the selected subclaim. POEM, cream-use days, or parent safety wording do not establish safety or generate new harm incidence or instructions on bathing frequency/treatment behavior.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Between-arm testing, collection, baseline/concomitant treatment, discontinuation, and relatedness. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M19 §19.1.2–19.2.4; Chamgap adaptation; M19 §19.2.2–19.2.4, M03 §3.2.3; Chamgap adaptation; M19 §19.2.2–19.2.4; design considerations; detailed confounding records are Chamgap design; Chamgap interpretation boundary; M19 is a reference principle, not execution of an official causality tool",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Separate actual reporting levels for efficacy/behavior and harms. This is a proposal; no new investigation, calculation, or trial was performed."
    },
    {
      "item_id": "N25",
      "question_type": "Evidence condition",
      "question": "How are the same reports, populations, and related sheets shared?",
      "needed": "Online trial, pediatric crossover, review, and report/replication relationships",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Online trial, pediatric crossover, review, and report/replication relationships.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Online trial, pediatric crossover, review, and report/replication relationships. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "Study/report distinction in M04 §4.6.1–4.6.2; Cohort/outcome linkage is Chamgap application; M04 §4.6.1–4.6.2 and M15 §15.3.1; Chamgap application",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Separate unrecorded unique clinical totals from report/material entries. This is a proposal; no new investigation, calculation, or trial was performed."
    },
    {
      "item_id": "N26",
      "question_type": "Harm-information gaps supplementing the efficacy table",
      "question": "Is the selected result extended to optimal frequency, long-term outcomes, or other products?",
      "needed": "Direct evidence for 4 weeks/population, environments, separate products, and treatment behavior",
      "role": "Supplementary",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Direct evidence for 4 weeks/population, environments, separate products, and treatment behavior.",
      "application_exception": "Addresses safety-material gaps for the selected subclaim. POEM, cream-use days, or parent safety wording do not establish safety or generate new harm incidence or instructions on bathing frequency/treatment behavior.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Direct evidence for 4 weeks/population, environments, separate products, and treatment behavior. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M03 §3.2.1–3.2.4; dose, duration and effect-modification details are Chamgap design; M03 §3.2.4; Chamgap extrapolation boundary; M19 §19.1.2–19.2.4; Chamgap adaptation; M19 §19.1.2–19.2.4; Chamgap adaptation",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Separate other products, environments, and long-term questions from the current secondary result. This is a proposal; no new investigation, calculation, or trial was performed."
    },
    {
      "item_id": "N27",
      "question_type": "Evidence condition",
      "question": "What history do parent D30, languages, dates, empty values, and corrections represent?",
      "needed": "Selected C/parent D30, original axes, Korean/English manuscript, and cross-checks/corrections",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Selected C/parent D30, original axes, Korean/English manuscript, and cross-checks/corrections.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Selected C/parent D30, original axes, Korean/English manuscript, and cross-checks/corrections. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M04 §4.5, §4.6.3; current material-conversion limits reflect review scope and our own design; M04 §4.6.3, M15 §15.3.1–15.3.3; status distinctions are our own design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Distinguish the original record from production and amendment events. This is a proposal; no new investigation, calculation or trial was performed."
    },
    {
      "item_id": "N28",
      "question_type": "Evidence condition",
      "question": "What is the reading level of summaries and external papers/plans/disclosures?",
      "needed": "Material types, actual acquisition/reading, and original links",
      "role": "Required",
      "role_reason": "A production item connecting required and available material for the selected question by distinguishing: Material types, actual acquisition/reading, and original links.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Corresponding original material and analysis scope must be supplied, with unverified matters distinguished, for: Material types, actual acquisition/reading, and original links. Stored wording is linked here; the original content review remains incomplete.",
      "basis": "M04 §4.5–4.6 material collection/selection principles; acquisition/reading separation and hyperlink specifications are internally designed; M04 §4.5, §4.6.3; limits of this material conversion follow the review scope and internal design",
      "condition_origin": "Production conditions for turning the preserved account into a table; existing content review remains incomplete, and this is not a record of running an official tool or completing content review",
      "proposed_research": "Update material-specific existence, acquisition, actual reading, and access history separately. This is a proposal; no new investigation, calculation, or trial was performed."
    }
  ]
}