{
  "schema_version": "chamgap-public-criteria-1.0",
  "title": "Two-year caloric restriction × slower DunedinPACE: a post hoc DNA-surrogate evidence checklist",
  "language": "en",
  "translation_date": "2026-10-11",
  "criteria_version": "1.0",
  "criteria_date": "2026-10-06",
  "condition_origin": "Chamgap's own application conditions",
  "method_sources": [
    {
      "id": "M03",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03",
      "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13",
      "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.",
      "review_level": "Preserved methodology connections were reused for preparation. No new review of methodological content, reassessment or external-link checks were performed."
    },
    {
      "id": "M04",
      "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04",
      "section": "§4.5, §4.6.1–4.6.3, MECIR C42",
      "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.",
      "review_level": "Preserved methodology connections were reused for preparation. No new review of methodological content, reassessment or external-link checks were performed."
    },
    {
      "id": "M08",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08",
      "section": "§8.1–8.2.3, Table 8.2.a",
      "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.",
      "review_level": "Preserved methodology connections were reused for preparation. No new review of methodological content, reassessment or external-link checks were performed."
    },
    {
      "id": "M15",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15",
      "section": "§15.2.4, §15.3.1–15.3.3",
      "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.",
      "review_level": "Preserved methodology connections were reused for preparation. No new review of methodological content, reassessment or external-link checks were performed."
    },
    {
      "id": "M19",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19",
      "section": "§19.1.2, §19.2.1–19.2.4",
      "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.",
      "review_level": "Preserved methodology connections were reused for preparation. No new review of methodological content, reassessment or external-link checks were performed."
    }
  ],
  "status_dictionary": {
    "Partly verified": "Some information exists in the preserved review summary; detailed original materials remain unverified. This does not certify a passed review or clinical efficacy.",
    "Unverified": "Detailed materials for the selected condition could not be established within the stored scope; this does not mean zero effect, zero studies or safety",
    "Review incomplete": "Review of existing content incomplete",
    "Met": "Use only within the relevant conditions after existing content review; no automatic designation in this preparation",
    "Not reported": "Distinguish only within materials actually read; do not turn unread external materials into unreported findings",
    "Inaccessible": "Not applied during this preparation because actual access was not tested",
    "Not applicable": "Use with a reason for non-applicability based on an explicit question boundary",
    "Conflicting data": "Judge after actual material comparison; review was not performed during this preparation",
    "Insufficient evidence for the conditions": "Do not use as a clinical grade encompassing currently unread materials"
  },
  "requirements": [
    {
      "item_id": "N01",
      "question_type": "Comparative efficacy",
      "question": "Are the original DunedinPACE subclaim assessment and the parent pace-of-aging context kept separate?",
      "needed": "Separate records of the original claim, grade, note and parent values",
      "role": "Required",
      "role_reason": "An individual condition for recording the selected measure, time, original values and applicability limits",
      "application_exception": "Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.",
      "criterion": "Separate records of the original claim, grade, note and parent values",
      "basis": "Slower DunedinPACE",
      "condition_origin": "Question-specific application conditions; existing content review remains incomplete and common definitions are not automatically fulfilled",
      "proposed_research": "If additional original material is provided, connect the selected measure separately from the parent context."
    },
    {
      "item_id": "N02",
      "question_type": "Comparative efficacy",
      "question": "What population and applicability limits concern healthy non-obese adults?",
      "needed": "Age, baseline condition, obesity status, eligibility and population-specific denominators",
      "role": "Required",
      "role_reason": "An individual condition for recording the selected measure, time, original values and applicability limits",
      "application_exception": "Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.",
      "criterion": "Age, baseline condition, obesity status, eligibility and population-specific denominators",
      "basis": "Slower DunedinPACE",
      "condition_origin": "Question-specific application conditions; existing content review remains incomplete and common definitions are not automatically fulfilled",
      "proposed_research": "Obtain original eligibility, baseline characteristics and recruitment denominators."
    },
    {
      "item_id": "N03",
      "question_type": "Comparative efficacy",
      "question": "Are the target caloric restriction and achieved average exposure distinguished?",
      "needed": "Study records of the original target, achieved exposure, measurement, adherence and duration",
      "role": "Required",
      "role_reason": "An individual condition for recording the selected measure, time, original values and applicability limits",
      "application_exception": "Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.",
      "criterion": "Study records of the original target, achieved exposure, measurement, adherence and duration",
      "basis": "Slower DunedinPACE",
      "condition_origin": "Question-specific application conditions; existing content review remains incomplete and common definitions are not automatically fulfilled",
      "proposed_research": "Obtain original exposure measurements, adherence, support and change records."
    },
    {
      "item_id": "N04",
      "question_type": "Comparative efficacy",
      "question": "Can the intervention and control diets, support and concurrent exposures over two years be verified?",
      "needed": "Actual intervention and control diets, support, contact and concurrent management",
      "role": "Required",
      "role_reason": "An individual condition for recording the selected measure, time, original values and applicability limits",
      "application_exception": "Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.",
      "criterion": "Actual intervention and control diets, support, contact and concurrent management",
      "basis": "Slower DunedinPACE",
      "condition_origin": "Question-specific application conditions; existing content review remains incomplete and common definitions are not automatically fulfilled",
      "proposed_research": "Connect protocol records of the control, support, achieved exposure and concurrent management."
    },
    {
      "item_id": "N05",
      "question_type": "Comparative efficacy",
      "question": "Do 220 randomized participants, 2:1 allocation and the 197-person DNA sample share a denominator?",
      "needed": "Randomization, sample acquisition, measure-specific analyses and time-specific denominators",
      "role": "Required",
      "role_reason": "An individual condition for recording the selected measure, time, original values and applicability limits",
      "application_exception": "Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.",
      "criterion": "Randomization, sample acquisition, measure-specific analyses and time-specific denominators",
      "basis": "Slower DunedinPACE",
      "condition_origin": "Question-specific application conditions; existing content review remains incomplete and common definitions are not automatically fulfilled",
      "proposed_research": "Obtain original tables tracing allocation, DNA samples and analyses by time and measure."
    },
    {
      "item_id": "N06",
      "question_type": "Comparative efficacy",
      "question": "Do gaps remain concerning DNA sample selection, follow-up, missingness and the effect of interest?",
      "needed": "Sample selection, missingness by group, analysis populations, sensitivity analyses and original models",
      "role": "Required",
      "role_reason": "An individual condition for recording the selected measure, time, original values and applicability limits",
      "application_exception": "Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.",
      "criterion": "Sample selection, missingness by group, analysis populations, sensitivity analyses and original models",
      "basis": "Slower DunedinPACE",
      "condition_origin": "Question-specific application conditions; existing content review remains incomplete and common definitions are not automatically fulfilled",
      "proposed_research": "Obtain original sample-selection, group-specific missingness, analysis-population and sensitivity plans."
    },
    {
      "item_id": "N07",
      "question_type": "Comparative efficacy",
      "question": "Is DunedinPACE a pace measure distinct from clinical events?",
      "needed": "DNA measure definitions, measurement units, validation and measurement procedures",
      "role": "Required",
      "role_reason": "An individual condition for recording the selected measure, time, original values and applicability limits",
      "application_exception": "Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.",
      "criterion": "DNA measure definitions, measurement units, validation and measurement procedures",
      "basis": "Slower DunedinPACE",
      "condition_origin": "Question-specific application conditions; existing content review remains incomplete and common definitions are not automatically fulfilled",
      "proposed_research": "Obtain original measure definitions, validation, measurement, units and clinical-linkage material."
    },
    {
      "item_id": "N08",
      "question_type": "Comparative efficacy",
      "question": "Are details of DNA measurement, batches, normalization and measure calculation available?",
      "needed": "Original methods for samples, DNA measurement, batches, normalization and algorithms",
      "role": "Required",
      "role_reason": "An individual condition for recording the selected measure, time, original values and applicability limits",
      "application_exception": "Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.",
      "criterion": "Original methods for samples, DNA measurement, batches, normalization and algorithms",
      "basis": "Slower DunedinPACE",
      "condition_origin": "Question-specific application conditions; existing content review remains incomplete and common definitions are not automatically fulfilled",
      "proposed_research": "Obtain original laboratory, measure-calculation and quality-processing methods."
    },
    {
      "item_id": "N09",
      "question_type": "Comparative efficacy",
      "question": "Are the original 12-month DunedinPACE effect and CI preserved?",
      "needed": "Original effects, units, CIs, models and denominators by time",
      "role": "Required",
      "role_reason": "An individual condition for recording the selected measure, time, original values and applicability limits",
      "application_exception": "Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.",
      "criterion": "Original effects, units, CIs, models and denominators by time",
      "basis": "Slower DunedinPACE",
      "condition_origin": "Question-specific application conditions; existing content review remains incomplete and common definitions are not automatically fulfilled",
      "proposed_research": "Obtain the original 12-month model, adjustments, denominators, effect and CI."
    },
    {
      "item_id": "N10",
      "question_type": "Comparative efficacy",
      "question": "Is the 24-month DunedinPACE effect and interval preserved as a separate time-specific value?",
      "needed": "Original effects, original intervals, models and denominators by time",
      "role": "Required",
      "role_reason": "An individual condition for recording the selected measure, time, original values and applicability limits",
      "application_exception": "Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.",
      "criterion": "Original effects, original intervals, models and denominators by time",
      "basis": "Slower DunedinPACE",
      "condition_origin": "Question-specific application conditions; existing content review remains incomplete and common definitions are not automatically fulfilled",
      "proposed_research": "Obtain the original 24-month effect, interval level, model and time-specific denominators."
    },
    {
      "item_id": "N11",
      "question_type": "Comparative efficacy",
      "question": "What is the scope of P<0.003 and the roughly 2~3% wording?",
      "needed": "Links between time-specific tests, effect transformations and original estimates",
      "role": "Required",
      "role_reason": "An individual condition for recording the selected measure, time, original values and applicability limits",
      "application_exception": "Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.",
      "criterion": "Links between time-specific tests, effect transformations and original estimates",
      "basis": "Slower DunedinPACE",
      "condition_origin": "Question-specific application conditions; existing content review remains incomplete and common definitions are not automatically fulfilled",
      "proposed_research": "Obtain the original definitions and models for time-specific tests and percentage wording."
    },
    {
      "item_id": "N12",
      "question_type": "Comparative efficacy",
      "question": "Are the null PC PhenoAge and PC GrimAge findings preserved together?",
      "needed": "Original effects, intervals and tests by distinct measure and time",
      "role": "Required",
      "role_reason": "An individual condition for recording the selected measure, time, original values and applicability limits",
      "application_exception": "Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.",
      "criterion": "Original effects, intervals and tests by distinct measure and time",
      "basis": "Slower DunedinPACE",
      "condition_origin": "Question-specific application conditions; existing content review remains incomplete and common definitions are not automatically fulfilled",
      "proposed_research": "Obtain effects, CIs, P values and denominators separately for each PC measure and time."
    },
    {
      "item_id": "N13",
      "question_type": "Comparative efficacy",
      "question": "Do the pace measure and the two PC clocks use the same units and address the same question?",
      "needed": "Definitions, reference standards, units and interpretation limits for each measure",
      "role": "Required",
      "role_reason": "An individual condition for recording the selected measure, time, original values and applicability limits",
      "application_exception": "Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.",
      "criterion": "Definitions, reference standards, units and interpretation limits for each measure",
      "basis": "Slower DunedinPACE",
      "condition_origin": "Question-specific application conditions; existing content review remains incomplete and common definitions are not automatically fulfilled",
      "proposed_research": "Obtain original definitions, validation, units and applicability material for each measure."
    },
    {
      "item_id": "N14",
      "question_type": "Comparative efficacy",
      "question": "Are the post hoc analysis and the parent's prespecified clinical primary endpoint distinguished?",
      "needed": "Original registration, protocol, SAP, analysis timing and outcome hierarchy",
      "role": "Required",
      "role_reason": "An individual condition for recording the selected measure, time, original values and applicability limits",
      "application_exception": "Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.",
      "criterion": "Original registration, protocol, SAP, analysis timing and outcome hierarchy",
      "basis": "Slower DunedinPACE",
      "condition_origin": "Question-specific application conditions; existing content review remains incomplete and common definitions are not automatically fulfilled",
      "proposed_research": "Obtain original registration, protocol and SAP, and records of post hoc analysis selection and changes."
    },
    {
      "item_id": "N15",
      "question_type": "Comparative efficacy",
      "question": "Are the split findings across three measures and the multiple-outcome analysis plan preserved?",
      "needed": "Original plans for three measures, time points, models, tests and multiplicity handling",
      "role": "Required",
      "role_reason": "An individual condition for recording the selected measure, time, original values and applicability limits",
      "application_exception": "Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.",
      "criterion": "Original plans for three measures, time points, models, tests and multiplicity handling",
      "basis": "Slower DunedinPACE",
      "condition_origin": "Question-specific application conditions; existing content review remains incomplete and common definitions are not automatically fulfilled",
      "proposed_research": "Obtain the DNA analysis's original outcome list, time points, tests, adjustments and selective-reporting plan."
    },
    {
      "item_id": "N16",
      "question_type": "Comparative efficacy",
      "question": "Is the absence of a clinical minimum-effect threshold and prespecified success boundary preserved?",
      "needed": "Clinical validation, minimum-effect thresholds and plans for each measure",
      "role": "Required",
      "role_reason": "An individual condition for recording the selected measure, time, original values and applicability limits",
      "application_exception": "Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.",
      "criterion": "Clinical validation, minimum-effect thresholds and plans for each measure",
      "basis": "Slower DunedinPACE",
      "condition_origin": "Question-specific application conditions; existing content review remains incomplete and common definitions are not automatically fulfilled",
      "proposed_research": "Connect clinical validation, prespecified thresholds and plans for each measure if provided."
    },
    {
      "item_id": "N17",
      "question_type": "Comparative efficacy",
      "question": "What is the original scope of allocation and analyst blinding?",
      "needed": "Parent allocation, blinding of DNA laboratory staff or analysts, and analysis procedures",
      "role": "Required",
      "role_reason": "An individual condition for recording the selected measure, time, original values and applicability limits",
      "application_exception": "Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.",
      "criterion": "Parent allocation, blinding of DNA laboratory staff or analysts, and analysis procedures",
      "basis": "Slower DunedinPACE",
      "condition_origin": "Question-specific application conditions; existing content review remains incomplete and common definitions are not automatically fulfilled",
      "proposed_research": "Obtain original allocation, laboratory and measure-analysis methods and blinding roles."
    },
    {
      "item_id": "N18",
      "question_type": "Comparative efficacy",
      "question": "Is the relationship between achieved restriction, adherence, weight changes and measure effects directly verified?",
      "needed": "Original achieved exposure, adherence, concurrent changes and effects of interest",
      "role": "Required",
      "role_reason": "An individual condition for recording the selected measure, time, original values and applicability limits",
      "application_exception": "Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.",
      "criterion": "Original achieved exposure, adherence, concurrent changes and effects of interest",
      "basis": "Slower DunedinPACE",
      "condition_origin": "Question-specific application conditions; existing content review remains incomplete and common definitions are not automatically fulfilled",
      "proposed_research": "Obtain achieved exposure, adherence, concurrent changes and prespecified mediation or effect-of-interest material."
    },
    {
      "item_id": "N19",
      "question_type": "Comparative efficacy",
      "question": "Do gaps remain concerning persistence after 12 or 24 months, mechanisms and other aging measures?",
      "needed": "Follow-up measures, duration, denominators, original effects and direct mechanism evidence",
      "role": "Required",
      "role_reason": "An individual condition for recording the selected measure, time, original values and applicability limits",
      "application_exception": "Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.",
      "criterion": "Follow-up measures, duration, denominators, original effects and direct mechanism evidence",
      "basis": "Slower DunedinPACE",
      "condition_origin": "Question-specific application conditions; existing content review remains incomplete and common definitions are not automatically fulfilled",
      "proposed_research": "Obtain direct post-intervention follow-up and original measurements, denominators and effects separately by measure."
    },
    {
      "item_id": "N20",
      "question_type": "Comparative efficacy",
      "question": "Has the result been kept separate from disease, disability, death, lifespan and independent-living outcomes?",
      "needed": "Direct clinical endpoints, adequate follow-up, events, denominators and effects",
      "role": "Required",
      "role_reason": "An individual condition for recording the selected measure, time, original values and applicability limits",
      "application_exception": "Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.",
      "criterion": "Direct clinical endpoints, adequate follow-up, events, denominators and effects",
      "basis": "Slower DunedinPACE",
      "condition_origin": "Question-specific application conditions; existing content review remains incomplete and common definitions are not automatically fulfilled",
      "proposed_research": "Direct definitions, long-term follow-up, denominators and effect data are needed for each clinical outcome."
    },
    {
      "item_id": "N21",
      "question_type": "Comparative efficacy",
      "question": "Are the two sibling sheets, two time points and one post hoc report kept from being independently summed?",
      "needed": "Relationships among the parent trial, post hoc report, same participants, measures and time points",
      "role": "Required",
      "role_reason": "An individual condition for recording the selected measure, time, original values and applicability limits",
      "application_exception": "Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.",
      "criterion": "Relationships among the parent trial, post hoc report, same participants, measures and time points",
      "basis": "Slower DunedinPACE",
      "condition_origin": "Question-specific application conditions; existing content review remains incomplete and common definitions are not automatically fulfilled",
      "proposed_research": "Link additional reports through original trial identifiers while retaining relationships to the same population."
    },
    {
      "item_id": "N22",
      "question_type": "Comparative efficacy",
      "question": "Are funding and DunedinPACE invention and commercial-licensing interests distinguished?",
      "needed": "Funding, authors, invention, licensing, provision and analysis roles",
      "role": "Required",
      "role_reason": "An individual condition for recording the selected measure, time, original values and applicability limits",
      "application_exception": "Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.",
      "criterion": "Funding, authors, invention, licensing, provision and analysis roles",
      "basis": "Slower DunedinPACE",
      "condition_origin": "Question-specific application conditions; existing content review remains incomplete and common definitions are not automatically fulfilled",
      "proposed_research": "Obtain original funding, licensing, affiliations, product or service provision, analysis and manuscript roles separately."
    },
    {
      "item_id": "N23",
      "question_type": "Supplementary harm evidence",
      "question": "Does absent safety reporting establish that the parent trial had no harms?",
      "needed": "Harm plans, events by group and exposure denominators for this analysis and the parent trial",
      "role": "Required",
      "role_reason": "An individual condition for recording the selected measure, time, original values and applicability limits",
      "application_exception": "Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.",
      "criterion": "Harm plans, events by group and exposure denominators for this analysis and the parent trial",
      "basis": "Slower DunedinPACE",
      "condition_origin": "Question-specific application conditions; existing content review remains incomplete and common definitions are not automatically fulfilled",
      "proposed_research": "Obtain the parent trial's original harm plans, events by group, exposure, discontinuation and denominators separately."
    },
    {
      "item_id": "N24",
      "question_type": "Supplementary harm evidence",
      "question": "Do gaps remain concerning long-term or rare harms under two-year achieved exposure?",
      "needed": "Direct harm data by achieved exposure, discontinuation, severity and duration",
      "role": "Required",
      "role_reason": "An individual condition for recording the selected measure, time, original values and applicability limits",
      "application_exception": "Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.",
      "criterion": "Direct harm data by achieved exposure, discontinuation, severity and duration",
      "basis": "Slower DunedinPACE",
      "condition_origin": "Question-specific application conditions; existing content review remains incomplete and common definitions are not automatically fulfilled",
      "proposed_research": "Obtain group-specific harms, discontinuation, rare events and long-term data from the parent trial and follow-up reports."
    },
    {
      "item_id": "N25",
      "question_type": "Supplementary harm evidence",
      "question": "Are harm replication, applicability to other populations or exposures, and dietary instructions distinguished?",
      "needed": "Direct effects, harms, exposures and same-population relationships by population",
      "role": "Required",
      "role_reason": "An individual condition for recording the selected measure, time, original values and applicability limits",
      "application_exception": "Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.",
      "criterion": "Direct effects, harms, exposures and same-population relationships by population",
      "basis": "Slower DunedinPACE",
      "condition_origin": "Question-specific application conditions; existing content review remains incomplete and common definitions are not automatically fulfilled",
      "proposed_research": "Connect direct comparisons and harm evidence for new populations or exposures separately."
    },
    {
      "item_id": "N26",
      "question_type": "Comparative efficacy",
      "question": "Are the stored summary, PubMed link and registration identifier distinguished from materials actually read?",
      "needed": "Separate access records for the summary, abstract, full text, registration, protocol and SAP",
      "role": "Required",
      "role_reason": "An individual condition for recording the selected measure, time, original values and applicability limits",
      "application_exception": "Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.",
      "criterion": "Separate access records for the summary, abstract, full text, registration, protocol and SAP",
      "basis": "Slower DunedinPACE",
      "condition_origin": "Question-specific application conditions; existing content review remains incomplete and common definitions are not automatically fulfilled",
      "proposed_research": "Connect additional provided material with its individual access status."
    },
    {
      "item_id": "N27",
      "question_type": "Comparative efficacy",
      "question": "Are original dates, Korean and English text, empty values, subclaim and parent values, and review status preserved?",
      "needed": "Distinction among the complete original, selected assessment record, history and current production status",
      "role": "Supplementary",
      "role_reason": "An individual condition for recording the selected measure, time, original values and applicability limits",
      "application_exception": "Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.",
      "criterion": "Distinction among the complete original, selected assessment record, history and current production status",
      "basis": "Slower DunedinPACE",
      "condition_origin": "Question-specific application conditions; existing content review remains incomplete and common definitions are not automatically fulfilled",
      "proposed_research": "Proposal: Reflect additional materials and decisions through preservation of original wording and separate events."
    }
  ]
}