{
  "schema_version": "chamgap-public-criteria-1.0",
  "title": "Antidepressant maintenance × complete relapse prevention — evidence sheet distinguishing remaining 52-week events",
  "language": "en",
  "translation_date": "2026-10-11",
  "criteria_version": "1.0",
  "criteria_date": "2026-10-06",
  "condition_origin": "Chamgap's own application conditions",
  "method_sources": [
    {
      "id": "M03",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03",
      "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13",
      "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.",
      "review_level": "Preserved methodology connections were reused for preparation. No new review of methodological content, reassessment or external-link checks were performed."
    },
    {
      "id": "M04",
      "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04",
      "section": "§4.5, §4.6.1–4.6.3, MECIR C42",
      "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.",
      "review_level": "Preserved methodology connections were reused for preparation. No new review of methodological content, reassessment or external-link checks were performed."
    },
    {
      "id": "M08",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08",
      "section": "§8.1–8.2.3, Table 8.2.a",
      "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.",
      "review_level": "Preserved methodology connections were reused for preparation. No new review of methodological content, reassessment or external-link checks were performed."
    },
    {
      "id": "M15",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15",
      "section": "§15.2.4, §15.3.1–15.3.3",
      "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.",
      "review_level": "Preserved methodology connections were reused for preparation. No new review of methodological content, reassessment or external-link checks were performed."
    },
    {
      "id": "M19",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19",
      "section": "§19.1.2, §19.2.1–19.2.4",
      "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.",
      "review_level": "Preserved methodology connections were reused for preparation. No new review of methodological content, reassessment or external-link checks were performed."
    }
  ],
  "status_dictionary": {
    "Partly verified": "Some information exists in the preserved review summary; detailed original materials remain unverified. This does not certify a passed review or clinical efficacy.",
    "Unverified": "Detailed materials for the selected condition could not be established within the stored scope; this does not mean zero effect, zero studies or safety",
    "Review incomplete": "Existing content review pending",
    "Met": "Use only within the relevant conditions after existing content review; no automatic designation in this preparation",
    "Not reported": "Distinguish only within materials actually read; do not turn unread external materials into unreported findings",
    "Inaccessible": "Not applied during this preparation because actual access was not tested",
    "Not applicable": "Use with a reason for non-applicability based on an explicit question boundary",
    "Conflicting data": "Judge after actual material comparison; review was not performed during this preparation",
    "Insufficient evidence for the conditions": "Do not use as a clinical grade encompassing currently unread materials"
  },
  "requirements": [
    {
      "item_id": "N01",
      "question_type": "Comparative efficacy",
      "question": "Have the complete-prevention claim, subclaim grade D and parent relapse-reduction grade B been kept separate?",
      "needed": "Separate preservation of the subclaim wording, grade and note and the parent verdict",
      "role": "Required",
      "role_reason": "Individual production condition recording the selected claim, original events, denominators, duration and interpretive boundaries",
      "application_exception": "Unread external material, other questions or out-of-scope outcomes do not substitute for satisfied conditions, zero effect or safety.",
      "criterion": "Separate preservation of the subclaim wording, grade and note and the parent verdict",
      "basis": "Maintenance completely prevents relapse",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Proposal: Link additional materials while distinguishing complete prevention from average relapse reduction."
    },
    {
      "item_id": "N02",
      "question_type": "Comparative efficacy",
      "question": "What were the original population's remission, long-term use and consideration of discontinuation conditions?",
      "needed": "Age, remission, previous episodes, treatment history, eligibility and denominators",
      "role": "Required",
      "role_reason": "Individual production condition recording the selected claim, original events, denominators, duration and interpretive boundaries",
      "application_exception": "Unread external material, other questions or out-of-scope outcomes do not substitute for satisfied conditions, zero effect or safety.",
      "criterion": "Age, remission, previous episodes, treatment history, eligibility and denominators",
      "basis": "Maintenance completely prevents relapse",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Proposal: Obtain original eligibility, baseline characteristics, remission assessment and relapse history."
    },
    {
      "item_id": "N03",
      "question_type": "Comparative efficacy",
      "question": "Have the four antidepressants' specific study conditions been extended to all medications?",
      "needed": "Recording included medications, original study doses, exposure and group composition",
      "role": "Required",
      "role_reason": "Individual production condition recording the selected claim, original events, denominators, duration and interpretive boundaries",
      "application_exception": "Unread external material, other questions or out-of-scope outcomes do not substitute for satisfied conditions, zero effect or safety.",
      "criterion": "Recording included medications, original study doses, exposure and group composition",
      "basis": "Maintenance completely prevents relapse",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Proposal: Obtain medication-specific inclusion, baseline exposure, denominators and prespecified subgroup materials."
    },
    {
      "item_id": "N04",
      "question_type": "Comparative efficacy",
      "question": "What was the actual comparison between maintenance and tapering to matching placebo?",
      "needed": "Historical interventions, placebo switching, common treatments and actual exposure",
      "role": "Required",
      "role_reason": "Individual production condition recording the selected claim, original events, denominators, duration and interpretive boundaries",
      "application_exception": "Unread external material, other questions or out-of-scope outcomes do not substitute for satisfied conditions, zero effect or safety.",
      "criterion": "Historical interventions, placebo switching, common treatments and actual exposure",
      "basis": "Maintenance completely prevents relapse",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Proposal: Obtain original intervention, placebo, actual exposure, common-treatment and change materials."
    },
    {
      "item_id": "N05",
      "question_type": "Comparative efficacy",
      "question": "Are the 478 randomized participants and group-specific absolute relapse denominators preserved?",
      "needed": "Randomization, analysis, group-specific absolute events and follow-up denominators",
      "role": "Required",
      "role_reason": "Individual production condition recording the selected claim, original events, denominators, duration and interpretive boundaries",
      "application_exception": "Unread external material, other questions or out-of-scope outcomes do not substitute for satisfied conditions, zero effect or safety.",
      "criterion": "Randomization, analysis, group-specific absolute events and follow-up denominators",
      "basis": "Maintenance completely prevents relapse",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Proposal: Obtain original participant flow, allocation, absolute event tables and missing-data mapping by group."
    },
    {
      "item_id": "N06",
      "question_type": "Comparative efficacy",
      "question": "Does the complete-prevention claim agree with the actual maintenance-group events?",
      "needed": "Direct evidence for the selected duration, group, relapse definition and event counts",
      "role": "Required",
      "role_reason": "Individual production condition recording the selected claim, original events, denominators, duration and interpretive boundaries",
      "application_exception": "Unread external material, other questions or out-of-scope outcomes do not substitute for satisfied conditions, zero effect or safety.",
      "criterion": "Direct evidence for the selected duration, group, relapse definition and event counts",
      "basis": "Maintenance completely prevents relapse",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Proposal: Link original relapse definitions, ascertainment, events by duration and scope of individual applicability."
    },
    {
      "item_id": "N07",
      "question_type": "Comparative efficacy",
      "question": "What were the relapse symptom instrument, assessment and ascertainment times?",
      "needed": "Instrument, episode definition, ascertainment, measurement times and group denominators",
      "role": "Required",
      "role_reason": "Individual production condition recording the selected claim, original events, denominators, duration and interpretive boundaries",
      "application_exception": "Unread external material, other questions or out-of-scope outcomes do not substitute for satisfied conditions, zero effect or safety.",
      "criterion": "Instrument, episode definition, ascertainment, measurement times and group denominators",
      "basis": "Maintenance completely prevents relapse",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Proposal: Obtain original relapse definitions, instrument, assessments, ascertainment times and tables."
    },
    {
      "item_id": "N08",
      "question_type": "Comparative efficacy",
      "question": "Are 39% versus 56% and the absolute 17%p difference preserved as originally recorded?",
      "needed": "Relapsing participants, denominators, original proportions, absolute difference and uncertainty by group",
      "role": "Required",
      "role_reason": "Individual production condition recording the selected claim, original events, denominators, duration and interpretive boundaries",
      "application_exception": "Unread external material, other questions or out-of-scope outcomes do not substitute for satisfied conditions, zero effect or safety.",
      "criterion": "Relapsing participants, denominators, original proportions, absolute difference and uncertainty by group",
      "basis": "Maintenance completely prevents relapse",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Proposal: Obtain original absolute-difference, CI, denominator and test materials."
    },
    {
      "item_id": "N09",
      "question_type": "Comparative efficacy",
      "question": "Are the discontinuation-versus-maintenance HR direction, CI and P preserved?",
      "needed": "Time-to-event effect, comparison direction, CI, test and model",
      "role": "Required",
      "role_reason": "Individual production condition recording the selected claim, original events, denominators, duration and interpretive boundaries",
      "application_exception": "Unread external material, other questions or out-of-scope outcomes do not substitute for satisfied conditions, zero effect or safety.",
      "criterion": "Time-to-event effect, comparison direction, CI, test and model",
      "basis": "Maintenance completely prevents relapse",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Proposal: Obtain the original effect of interest, HR direction, model, tests and denominators."
    },
    {
      "item_id": "N10",
      "question_type": "Comparative efficacy",
      "question": "Are the 468 participants in the primary time-to-event analysis the same denominator as the 478 for absolute relapse counts?",
      "needed": "Mapping relapse timing, event occurrence, complete-case exclusions and denominators",
      "role": "Required",
      "role_reason": "Individual production condition recording the selected claim, original events, denominators, duration and interpretive boundaries",
      "application_exception": "Unread external material, other questions or out-of-scope outcomes do not substitute for satisfied conditions, zero effect or safety.",
      "criterion": "Mapping relapse timing, event occurrence, complete-case exclusions and denominators",
      "basis": "Maintenance completely prevents relapse",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Proposal: Obtain original analysis populations, missing timing, group denominators and event mapping."
    },
    {
      "item_id": "N11",
      "question_type": "Comparative efficacy",
      "question": "Are the best- and worst-case sensitivity analyses and gaps in effect magnitude retained?",
      "needed": "Missing-data assumptions, omissions by group, sensitivity models, effects and intervals",
      "role": "Required",
      "role_reason": "Individual production condition recording the selected claim, original events, denominators, duration and interpretive boundaries",
      "application_exception": "Unread external material, other questions or out-of-scope outcomes do not substitute for satisfied conditions, zero effect or safety.",
      "criterion": "Missing-data assumptions, omissions by group, sensitivity models, effects and intervals",
      "basis": "Maintenance completely prevents relapse",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Proposal: Obtain original sensitivity-analysis plans, assumptions, effects, intervals and denominators."
    },
    {
      "item_id": "N12",
      "question_type": "Comparative efficacy",
      "question": "Are adherence of 70% and 52% and restarting of 39% distinguished from relapse proportions?",
      "needed": "Actual exposure, adherence definitions, restarting, duration and event relationships",
      "role": "Required",
      "role_reason": "Individual production condition recording the selected claim, original events, denominators, duration and interpretive boundaries",
      "application_exception": "Unread external material, other questions or out-of-scope outcomes do not substitute for satisfied conditions, zero effect or safety.",
      "criterion": "Actual exposure, adherence definitions, restarting, duration and event relationships",
      "basis": "Maintenance completely prevents relapse",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Proposal: Obtain original exposure, adherence, restarting, timing, event mapping and effects of interest."
    },
    {
      "item_id": "N13",
      "question_type": "Comparative efficacy",
      "question": "Has the magnitude of possible withdrawal-versus-relapse misclassification been established?",
      "needed": "Distinguishing withdrawal and relapse, measurement, original models and sensitivity analyses",
      "role": "Required",
      "role_reason": "Individual production condition recording the selected claim, original events, denominators, duration and interpretive boundaries",
      "application_exception": "Unread external material, other questions or out-of-scope outcomes do not substitute for satisfied conditions, zero effect or safety.",
      "criterion": "Distinguishing withdrawal and relapse, measurement, original models and sensitivity analyses",
      "basis": "Maintenance completely prevents relapse",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Proposal: Obtain original withdrawal and relapse definitions, timing, assessment, sensitivity and distinction analyses."
    },
    {
      "item_id": "N14",
      "question_type": "Comparative efficacy",
      "question": "Have the original modified DESS means, difference, CI and direction been kept separate?",
      "needed": "Withdrawal instrument, time point, group order, original difference, interval and denominators",
      "role": "Required",
      "role_reason": "Individual production condition recording the selected claim, original events, denominators, duration and interpretive boundaries",
      "application_exception": "Unread external material, other questions or out-of-scope outcomes do not substitute for satisfied conditions, zero effect or safety.",
      "criterion": "Withdrawal instrument, time point, group order, original difference, interval and denominators",
      "basis": "Maintenance completely prevents relapse",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Proposal: Obtain original DESS measurements, model, recorded difference, group denominators and repeated time points."
    },
    {
      "item_id": "N15",
      "question_type": "Comparative efficacy",
      "question": "Have matching-tablet blinding and limitations of actual allocation guesses been distinguished?",
      "needed": "Allocation, concealment, blinding, allocation guesses and analyst procedures",
      "role": "Required",
      "role_reason": "Individual production condition recording the selected claim, original events, denominators, duration and interpretive boundaries",
      "application_exception": "Unread external material, other questions or out-of-scope outcomes do not substitute for satisfied conditions, zero effect or safety.",
      "criterion": "Allocation, concealment, blinding, allocation guesses and analyst procedures",
      "basis": "Maintenance completely prevents relapse",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Proposal: Obtain original blinding, guessing, allocation, measurement and analysis procedures."
    },
    {
      "item_id": "N16",
      "question_type": "Comparative efficacy",
      "question": "Are the prespecified first-relapse endpoint, registration and analysis hierarchy actually linked?",
      "needed": "Registration, protocol, SAP, original primary endpoint, changes and multiplicity plans",
      "role": "Required",
      "role_reason": "Individual production condition recording the selected claim, original events, denominators, duration and interpretive boundaries",
      "application_exception": "Unread external material, other questions or out-of-scope outcomes do not substitute for satisfied conditions, zero effect or safety.",
      "criterion": "Registration, protocol, SAP, original primary endpoint, changes and multiplicity plans",
      "basis": "Maintenance completely prevents relapse",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Proposal: Obtain original registration, plans, analysis hierarchy and change history."
    },
    {
      "item_id": "N17",
      "question_type": "Comparative efficacy",
      "question": "Do gaps in secondary outcomes, medication or baseline-history subgroups and individual prediction remain?",
      "needed": "Prespecified subgroups, interactions, denominators, effects and prediction materials",
      "role": "Required",
      "role_reason": "Individual production condition recording the selected claim, original events, denominators, duration and interpretive boundaries",
      "application_exception": "Unread external material, other questions or out-of-scope outcomes do not substitute for satisfied conditions, zero effect or safety.",
      "criterion": "Prespecified subgroups, interactions, denominators, effects and prediction materials",
      "basis": "Maintenance completely prevents relapse",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Proposal: Obtain original subgroup, interaction, individual-prediction and secondary-outcome plans and denominators."
    },
    {
      "item_id": "N18",
      "question_type": "Comparative efficacy",
      "question": "Is the relationship to the other claim about 44% without relapse in discontinuation retained?",
      "needed": "Relationships among shared participants, relapse or non-relapse and other subclaims",
      "role": "Required",
      "role_reason": "Individual production condition recording the selected claim, original events, denominators, duration and interpretive boundaries",
      "application_exception": "Unread external material, other questions or out-of-scope outcomes do not substitute for satisfied conditions, zero effect or safety.",
      "criterion": "Relationships among shared participants, relapse or non-relapse and other subclaims",
      "basis": "Maintenance completely prevents relapse",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Proposal: Link the two subclaims while retaining their relationship to the same trial, duration and denominators."
    },
    {
      "item_id": "N19",
      "question_type": "Comparative efficacy",
      "question": "Has the 52-week effect been kept from extending to permanent prevention or other clinical outcomes?",
      "needed": "Direct outcomes including long-term follow-up, episodes, function and deaths",
      "role": "Required",
      "role_reason": "Individual production condition recording the selected claim, original events, denominators, duration and interpretive boundaries",
      "application_exception": "Unread external material, other questions or out-of-scope outcomes do not substitute for satisfied conditions, zero effect or safety.",
      "criterion": "Direct outcomes including long-term follow-up, episodes, function and deaths",
      "basis": "Maintenance completely prevents relapse",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Proposal: Obtain direct relapse, clinical-function and long-term outcome materials separately by duration."
    },
    {
      "item_id": "N20",
      "question_type": "Comparative efficacy",
      "question": "Do Kato's 40 studies, 8,890 participants and original responses concern the same population as ANTLER?",
      "needed": "Review populations, post-acute maintenance, durations, denominators and trial mapping",
      "role": "Required",
      "role_reason": "Individual production condition recording the selected claim, original events, denominators, duration and interpretive boundaries",
      "application_exception": "Unread external material, other questions or out-of-scope outcomes do not substitute for satisfied conditions, zero effect or safety.",
      "criterion": "Review populations, post-acute maintenance, durations, denominators and trial mapping",
      "basis": "Maintenance completely prevents relapse",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Proposal: Obtain the review's original eligibility, included trials, durations, denominators and relationship to ANTLER."
    },
    {
      "item_id": "N21",
      "question_type": "Comparative efficacy",
      "question": "Are review results of 20.9% maintenance versus 39.7% placebo and the OR, CI and P preserved within their original scope?",
      "needed": "Pooled relapse effects, group proportions, OR, intervals, tests and denominators",
      "role": "Required",
      "role_reason": "Individual production condition recording the selected claim, original events, denominators, duration and interpretive boundaries",
      "application_exception": "Unread external material, other questions or out-of-scope outcomes do not substitute for satisfied conditions, zero effect or safety.",
      "criterion": "Pooled relapse effects, group proportions, OR, intervals, tests and denominators",
      "basis": "Maintenance completely prevents relapse",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Proposal: Obtain original pooled models, trial-specific effects, denominators, definitions and heterogeneity."
    },
    {
      "item_id": "N22",
      "question_type": "Comparative efficacy",
      "question": "Have NEJM, the detailed NIHR report and the review been kept from being added as new independent trials?",
      "needed": "Relationships among original trials, additional reports, pooled materials, shared participants and sibling questions",
      "role": "Required",
      "role_reason": "Individual production condition recording the selected claim, original events, denominators, duration and interpretive boundaries",
      "application_exception": "Unread external material, other questions or out-of-scope outcomes do not substitute for satisfied conditions, zero effect or safety.",
      "criterion": "Relationships among original trials, additional reports, pooled materials, shared participants and sibling questions",
      "basis": "Maintenance completely prevents relapse",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Proposal: Link additional reports through original identifiers and preserve relationships among shared populations and included trials."
    },
    {
      "item_id": "N23",
      "question_type": "Comparative efficacy",
      "question": "Have gaps in public funding, sponsorship, product supply, affiliations and external analysis been distinguished?",
      "needed": "Cash support, medication or placebo supply, affiliations, external analysis and design or writing roles",
      "role": "Required",
      "role_reason": "Individual production condition recording the selected claim, original events, denominators, duration and interpretive boundaries",
      "application_exception": "Unread external material, other questions or out-of-scope outcomes do not substitute for satisfied conditions, zero effect or safety.",
      "criterion": "Cash support, medication or placebo supply, affiliations, external analysis and design or writing roles",
      "basis": "Maintenance completely prevents relapse",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Proposal: Obtain original support, supply, affiliations, research roles and analysis disclosures separately."
    },
    {
      "item_id": "N24",
      "question_type": "Comparative efficacy",
      "question": "Is the original information level for review funding and involvement in included trials retained?",
      "needed": "Review support, funding by original trial, authors and product or analysis roles",
      "role": "Required",
      "role_reason": "Individual production condition recording the selected claim, original events, denominators, duration and interpretive boundaries",
      "application_exception": "Unread external material, other questions or out-of-scope outcomes do not substitute for satisfied conditions, zero effect or safety.",
      "criterion": "Review support, funding by original trial, authors and product or analysis roles",
      "basis": "Maintenance completely prevents relapse",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Proposal: Obtain original review and trial-specific support, affiliations, products and analysis relationships."
    },
    {
      "item_id": "N25",
      "question_type": "Supplementary harm evidence",
      "question": "Are serious-adverse-event participant counts, proportions and denominators distinguished from relapse?",
      "needed": "SAE definitions, participants versus events, group denominators, relatedness and exposure tables",
      "role": "Required",
      "role_reason": "Individual production condition recording the selected claim, original events, denominators, duration and interpretive boundaries",
      "application_exception": "Unread external material, other questions or out-of-scope outcomes do not substitute for satisfied conditions, zero effect or safety.",
      "criterion": "SAE definitions, participants versus events, group denominators, relatedness and exposure tables",
      "basis": "Maintenance completely prevents relapse",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Proposal: Obtain original SAE definitions, group-specific events and participants, denominators, relatedness, exposure and discontinuation."
    },
    {
      "item_id": "N26",
      "question_type": "Supplementary harm evidence",
      "question": "Have the original duration and scope of 0 deaths or suicide attempts been distinguished from long-term absence of risk?",
      "needed": "Event definitions, collection, duration, exposure, denominators and rare-harm materials",
      "role": "Required",
      "role_reason": "Individual production condition recording the selected claim, original events, denominators, duration and interpretive boundaries",
      "application_exception": "Unread external material, other questions or out-of-scope outcomes do not substitute for satisfied conditions, zero effect or safety.",
      "criterion": "Event definitions, collection, duration, exposure, denominators and rare-harm materials",
      "basis": "Maintenance completely prevents relapse",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Proposal: Obtain original event collection, exposure, denominators, duration and long-term rare-harm materials."
    },
    {
      "item_id": "N27",
      "question_type": "Supplementary harm evidence",
      "question": "Do gaps remain in withdrawal symptoms, other maintenance-treatment harms and discontinuation applicability?",
      "needed": "Separate records of withdrawal, medication harms, discontinuation, exposure and long-term follow-up",
      "role": "Required",
      "role_reason": "Individual production condition recording the selected claim, original events, denominators, duration and interpretive boundaries",
      "application_exception": "Unread external material, other questions or out-of-scope outcomes do not substitute for satisfied conditions, zero effect or safety.",
      "criterion": "Separate records of withdrawal, medication harms, discontinuation, exposure and long-term follow-up",
      "basis": "Maintenance completely prevents relapse",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Proposal: Obtain original withdrawal, maintenance-medication harm, exposure, discontinuation and long-term materials separately."
    },
    {
      "item_id": "N28",
      "question_type": "Supplementary harm evidence",
      "question": "Have repeated harms and applicability to other medications, populations and exposures been kept from new certification?",
      "needed": "Direct effects or harms and report relationships by population, medication and duration",
      "role": "Required",
      "role_reason": "Individual production condition recording the selected claim, original events, denominators, duration and interpretive boundaries",
      "application_exception": "Unread external material, other questions or out-of-scope outcomes do not substitute for satisfied conditions, zero effect or safety.",
      "criterion": "Direct effects or harms and report relationships by population, medication and duration",
      "basis": "Maintenance completely prevents relapse",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Proposal: Link direct comparisons and harm materials for new populations, medications and exposures separately."
    },
    {
      "item_id": "N29",
      "question_type": "Comparative efficacy",
      "question": "Are the summary, three article URLs, registration records and original-material access distinguished?",
      "needed": "Individual bibliography, DOI, summary, external abstracts or full texts and registration or plan records",
      "role": "Required",
      "role_reason": "Individual production condition recording the selected claim, original events, denominators, duration and interpretive boundaries",
      "application_exception": "Unread external material, other questions or out-of-scope outcomes do not substitute for satisfied conditions, zero effect or safety.",
      "criterion": "Individual bibliography, DOI, summary, external abstracts or full texts and registration or plan records",
      "basis": "Maintenance completely prevents relapse",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Proposal: Link original materials supplied by the user with individual types and actual access status."
    },
    {
      "item_id": "N30",
      "question_type": "Comparative efficacy",
      "question": "Are the cutoff date, languages, empty values, original verdict, candidate history and production status preserved?",
      "needed": "Distinguishing the complete preserved summary, subclaim record, parent values, corrections and current review",
      "role": "Supplementary",
      "role_reason": "Individual production condition recording the selected claim, original events, denominators, duration and interpretive boundaries",
      "application_exception": "Unread external material, other questions or out-of-scope outcomes do not substitute for satisfied conditions, zero effect or safety.",
      "criterion": "Distinguishing the complete preserved summary, subclaim record, parent values, corrections and current review",
      "basis": "Maintenance completely prevents relapse",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Proposal: Reflect additional materials and decisions through preservation of original wording and separate events."
    }
  ]
}