{
  "schema_version": "chamgap-public-evidence-check-1.0",
  "public_id": "v2934-s0",
  "verdict_number": "2934",
  "title": "Twenty-four-hour antibiotic prophylaxis × Noninferior 90-day SSI — Evidence sheet distinguishing the prespecified margin and denominators",
  "view_version": "1.0",
  "view_created_date": "2026-10-10",
  "criteria_version": "1.0",
  "criteria_date": "2026-10-06",
  "review_date": null,
  "legacy_evidence_date": "2026-08-26",
  "review_scope": {
    "materials_read": "Existing review summaries and stored records of methodological application",
    "clinical_papers_directly_read": false,
    "new_clinical_search": false,
    "limitation": "The complete existing review summary was read for production, linking existing URLs and identifiers. External abstracts, full texts, registration, protocols and SAP were not newly read or checked.",
    "date_meaning": "This is the date the stored materials were checked, not the date of a new search of the clinical literature."
  },
  "claim_context": {
    "population": "Patients undergoing open cystectomy and urinary diversion at a single Swiss center; original eligibility and baseline details remain unread",
    "intervention": "Historical study condition of stopping prophylactic antibiotics 24 hours after surgery; not instructions on duration or use",
    "dose": "Drug-combination, dose and concomitant-use details remain unread; no individual antibiotic choice, use or stopping guidance is generated",
    "comparator": "Prophylactic antibiotics continued until catheter and stent removal; original median 8 days",
    "endpoint": "Noninferior 90-day CDC-defined SSI; preserving the original 10%p margin, 90% CI and 193-participant PP analysis",
    "duration": "Original SSI and mortality at 90 days; prophylaxis duration of 1 day (IQR1~1) versus 8 days (IQR7~10) is a historical exposure statistic",
    "excluded_extensions": [
      "Converting noninferiority into SSI superiority or exact equivalence",
      "Converting median exposure into mean total exposure or the same reduction for each individual",
      "Converting exposure or mechanism into direct reductions in resistance, costs or all harms",
      "Certifying 193-participant PP as all-randomized 196-participant ITT or as the exposure denominator",
      "Recommendations on antibiotic type, duration, use, stopping or treatment substitution"
    ]
  },
  "requirements": [
    {
      "item_id": "N01",
      "question_type": "Comparative efficacy",
      "question": "Are the original subclaim and grade distinguished from the parent judgment context?",
      "needed": "Separate records of the selected subclaim, grade and note, and the original parent verdict",
      "role": "Required",
      "role_reason": "Individual production conditions recording original selected claims, comparisons, denominators, periods and interpretive limits",
      "application_exception": "Unread external material, other questions or out-of-scope outcomes do not substitute for satisfied conditions, zero effect or safety.",
      "criterion": "Separate records of the selected subclaim, grade and note, and the original parent verdict",
      "basis": "Noninferior 90-day surgical-site infection",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Link additional materials separately to the relevant subclaim and parent context.",
      "current_reports": [
        "R01"
      ],
      "existence": "Material information recorded in the preserved review summary",
      "acquired_read": "Summary read; external materials not read",
      "observation": "The selected claim is noninferior 90-day surgical-site infection, with subclaim grade C and a note that the prespecified 10%p margin was met. The parent verdict is C, 56 points, Caution.",
      "condition_status": "Partly verified",
      "status_reason": "Only the relevant preserved-summary information is recorded; detailed original materials are unread and existing content review remains incomplete. Absent subclaim score, status and axes are not filled with parent values. This production does not establish a new verdict or grade certification.",
      "missingness": "Absent subclaim score, status and axes are not filled with parent values. This production does not establish a new verdict or grade certification.",
      "uncertainty": "Unread/unverified does not mean zero effect, zero events, safety or new clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Absent subclaim score, status and axes are not filled with parent values. This production does not establish a new verdict or grade certification."
    },
    {
      "item_id": "N02",
      "question_type": "Comparative efficacy",
      "question": "What surgery, population and center were actually studied?",
      "needed": "Eligibility, surgery type, urinary diversion, baseline characteristics and denominators",
      "role": "Required",
      "role_reason": "Individual production conditions recording original selected claims, comparisons, denominators, periods and interpretive limits",
      "application_exception": "Unread external material, other questions or out-of-scope outcomes do not substitute for satisfied conditions, zero effect or safety.",
      "criterion": "Eligibility, surgery type, urinary diversion, baseline characteristics and denominators",
      "basis": "Noninferior 90-day surgical-site infection",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Obtain the original eligibility, baseline characteristics, surgery, center and denominator records.",
      "current_reports": [
        "R01"
      ],
      "existence": "Material information recorded in the preserved review summary",
      "acquired_read": "Summary read; external materials not read",
      "observation": "PAPRAC included patients undergoing open cystectomy and urinary diversion at a single Swiss center.",
      "condition_status": "Partly verified",
      "status_reason": "Only the relevant preserved-summary information is recorded; detailed original materials are unread and existing content review remains incomplete. The preserved summary lacks detailed tables of age, eligibility exclusions, baseline risk and surgical details. Results are not automatically extended to robotic surgery or other populations.",
      "missingness": "The preserved summary lacks detailed tables of age, eligibility exclusions, baseline risk and surgical details. Results are not automatically extended to robotic surgery or other populations.",
      "uncertainty": "Unread/unverified does not mean zero effect, zero events, safety or new clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "The preserved summary lacks detailed tables of age, eligibility exclusions, baseline risk and surgical details. Results are not automatically extended to robotic surgery or other populations."
    },
    {
      "item_id": "N03",
      "question_type": "Comparative efficacy",
      "question": "What were the historical intervention and comparator exposure until catheter and stent removal?",
      "needed": "Original intervention, comparator, stopping criteria, actual exposure and accompanying care",
      "role": "Required",
      "role_reason": "Individual production conditions recording original selected claims, comparisons, denominators, periods and interpretive limits",
      "application_exception": "Unread external material, other questions or out-of-scope outcomes do not substitute for satisfied conditions, zero effect or safety.",
      "criterion": "Original intervention, comparator, stopping criteria, actual exposure and accompanying care",
      "basis": "Noninferior 90-day surgical-site infection",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Obtain the original arm-specific tables of drugs, prophylactic and treatment exposure, actual duration and accompanying care.",
      "current_reports": [
        "R01"
      ],
      "existence": "Material information recorded in the preserved review summary",
      "acquired_read": "Summary read; external materials not read",
      "observation": "The original study conditions were stopping prophylactic antibiotics 24 hours after surgery in the short arm and continuing until catheter and stent removal in the extended arm.",
      "condition_status": "Partly verified",
      "status_reason": "Only the relevant preserved-summary information is recorded; detailed original materials are unread and existing content review remains incomplete. No individual antibiotic type, duration, use or stopping recommendation is made. Details of exact drug combinations, doses, concomitant drugs and additional treatment exposure remain unread.",
      "missingness": "No individual antibiotic type, duration, use or stopping recommendation is made. Details of exact drug combinations, doses, concomitant drugs and additional treatment exposure remain unread.",
      "uncertainty": "Unread/unverified does not mean zero effect, zero events, safety or new clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "No individual antibiotic type, duration, use or stopping recommendation is made. Details of exact drug combinations, doses, concomitant drugs and additional treatment exposure remain unread."
    },
    {
      "item_id": "N04",
      "question_type": "Comparative efficacy",
      "question": "Are 196 randomized participants distinguished from 193 in the primary analysis and denominators 95/98?",
      "needed": "Arm-specific randomization, canceled surgery, analysis and follow-up flow",
      "role": "Required",
      "role_reason": "Individual production conditions recording original selected claims, comparisons, denominators, periods and interpretive limits",
      "application_exception": "Unread external material, other questions or out-of-scope outcomes do not substitute for satisfied conditions, zero effect or safety.",
      "criterion": "Arm-specific randomization, canceled surgery, analysis and follow-up flow",
      "basis": "Noninferior 90-day surgical-site infection",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Obtain the original participant flow, exclusion reasons, arm-specific allocation and analysis counts, and missing-data tables.",
      "current_reports": [
        "R01"
      ],
      "existence": "Material information recorded in the preserved review summary",
      "acquired_read": "Summary read; external materials not read",
      "observation": "After 196 participants were randomized, the prespecified per-protocol primary analysis included 193 (95/98), excluding 3 canceled surgeries.",
      "condition_status": "Partly verified",
      "status_reason": "Only the relevant preserved-summary information is recorded; detailed original materials are unread and existing content review remains incomplete. The summary lacks original arm-specific randomized counts, cancellations by arm and additional follow-up losses. No new totals, dropout rates or certification of an all-randomized ITT analysis are produced.",
      "missingness": "The summary lacks original arm-specific randomized counts, cancellations by arm and additional follow-up losses. No new totals, dropout rates or certification of an all-randomized ITT analysis are produced.",
      "uncertainty": "Unread/unverified does not mean zero effect, zero events, safety or new clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "The summary lacks original arm-specific randomized counts, cancellations by arm and additional follow-up losses. No new totals, dropout rates or certification of an all-randomized ITT analysis are produced."
    },
    {
      "item_id": "N05",
      "question_type": "Comparative efficacy",
      "question": "Are the open-label design and infection adjudicators' roles distinguished?",
      "needed": "Allocation, concealment, measurement, adjudicator and analyst procedures",
      "role": "Required",
      "role_reason": "Individual production conditions recording original selected claims, comparisons, denominators, periods and interpretive limits",
      "application_exception": "Unread external material, other questions or out-of-scope outcomes do not substitute for satisfied conditions, zero effect or safety.",
      "criterion": "Allocation, concealment, measurement, adjudicator and analyst procedures",
      "basis": "Noninferior 90-day surgical-site infection",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Obtain the original allocation, adjudication, blinding and analysis procedures.",
      "current_reports": [
        "R01"
      ],
      "existence": "Material information recorded in the preserved review summary",
      "acquired_read": "Summary read; external materials not read",
      "observation": "The original design was a single-center open-label noninferiority randomized trial. The record states that infectious-disease specialists and clinicians not involved in care adjudicated 90-day CDC-defined SSI.",
      "condition_status": "Partly verified",
      "status_reason": "Only the relevant preserved-summary information is recorded; detailed original materials are unread and existing content review remains incomplete. Non-involvement in care is not newly certified as blinding to allocation. Details of allocation concealment, assessor blinding and analyst independence remain unread.",
      "missingness": "Non-involvement in care is not newly certified as blinding to allocation. Details of allocation concealment, assessor blinding and analyst independence remain unread.",
      "uncertainty": "Unread/unverified does not mean zero effect, zero events, safety or new clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Non-involvement in care is not newly certified as blinding to allocation. Details of allocation concealment, assessor blinding and analyst independence remain unread."
    },
    {
      "item_id": "N06",
      "question_type": "Comparative efficacy",
      "question": "What is the actual access status of registration, protocol and analysis-plan materials?",
      "needed": "Original registration, protocol, SAP, outcome hierarchy and amendment history",
      "role": "Required",
      "role_reason": "Individual production conditions recording original selected claims, comparisons, denominators, periods and interpretive limits",
      "application_exception": "Unread external material, other questions or out-of-scope outcomes do not substitute for satisfied conditions, zero effect or safety.",
      "criterion": "Original registration, protocol, SAP, outcome hierarchy and amendment history",
      "basis": "Noninferior 90-day surgical-site infection",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Obtain the original registration, plans, analysis populations, hierarchy, amendments and multiplicity information.",
      "current_reports": [
        "R01"
      ],
      "existence": "Material information recorded in the preserved review summary",
      "acquired_read": "Summary read; external materials not read",
      "observation": "The registration identifier in the original evidence list is NCT03305627. The preserved summary records a prespecified per-protocol primary analysis and a prespecified 10%p margin.",
      "condition_status": "Partly verified",
      "status_reason": "Only the relevant preserved-summary information is recorded; detailed original materials are unread and existing content review remains incomplete. No new URL was constructed from the registration identifier, and registration, full text and plans were not read. Details of the original primary/secondary exposure hierarchy and testing plan remain unread.",
      "missingness": "No new URL was constructed from the registration identifier, and registration, full text and plans were not read. Details of the original primary/secondary exposure hierarchy and testing plan remain unread.",
      "uncertainty": "Unread/unverified does not mean zero effect, zero events, safety or new clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "No new URL was constructed from the registration identifier, and registration, full text and plans were not read. Details of the original primary/secondary exposure hierarchy and testing plan remain unread."
    },
    {
      "item_id": "N07",
      "question_type": "Comparative efficacy",
      "question": "What direct outcome is 90-day CDC-defined SSI?",
      "needed": "Infection definition, categories, ascertainment, time points and denominators",
      "role": "Required",
      "role_reason": "Individual production conditions recording original selected claims, comparisons, denominators, periods and interpretive limits",
      "application_exception": "Unread external material, other questions or out-of-scope outcomes do not substitute for satisfied conditions, zero effect or safety.",
      "criterion": "Infection definition, categories, ascertainment, time points and denominators",
      "basis": "Noninferior 90-day surgical-site infection",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Obtain the original CDC definitions, classification, ascertainment, results by time point and denominators.",
      "current_reports": [
        "R01"
      ],
      "existence": "Material information recorded in the preserved review summary",
      "acquired_read": "Summary read; external materials not read",
      "observation": "The selected question is noninferiority for CDC-defined surgical-site infection within 90 days. Infectious-disease specialists and clinicians not involved in care adjudicated the outcome.",
      "condition_status": "Partly verified",
      "status_reason": "Only the relevant preserved-summary information is recorded; detailed original materials are unread and existing content review remains incomplete. The summary lacks detailed definitions and results for superficial, deep and organ-space categories, and visit schedules. Other infection or wound measures are not substituted.",
      "missingness": "The summary lacks detailed definitions and results for superficial, deep and organ-space categories, and visit schedules. Other infection or wound measures are not substituted.",
      "uncertainty": "Unread/unverified does not mean zero effect, zero events, safety or new clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "The summary lacks detailed definitions and results for superficial, deep and organ-space categories, and visit schedules. Other infection or wound measures are not substituted."
    },
    {
      "item_id": "N08",
      "question_type": "Comparative efficacy",
      "question": "Are arm-specific SSI events 8/95 and 12/98 and original percentages preserved?",
      "needed": "Arm-specific events, people, denominators, original percentages and time window",
      "role": "Required",
      "role_reason": "Individual production conditions recording original selected claims, comparisons, denominators, periods and interpretive limits",
      "application_exception": "Unread external material, other questions or out-of-scope outcomes do not substitute for satisfied conditions, zero effect or safety.",
      "criterion": "Arm-specific events, people, denominators, original percentages and time window",
      "basis": "Noninferior 90-day surgical-site infection",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Obtain the original event tables, arm-specific denominators, repeated-infection records and analysis definitions.",
      "current_reports": [
        "R01"
      ],
      "existence": "Material information recorded in the preserved review summary",
      "acquired_read": "Summary read; external materials not read",
      "observation": "The original materials record 90-day SSI as 8/95 (8.4%) in the short arm versus 12/98 (12.2%) in the extended arm.",
      "condition_status": "Partly verified",
      "status_reason": "Only the relevant preserved-summary information is recorded; detailed original materials are unread and existing content review remains incomplete. People, repeated events, original denominators and all infections are not mixed. No new percentages, RR, event totals, P values or CI are calculated.",
      "missingness": "People, repeated events, original denominators and all infections are not mixed. No new percentages, RR, event totals, P values or CI are calculated.",
      "uncertainty": "Unread/unverified does not mean zero effect, zero events, safety or new clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "People, repeated events, original denominators and all infections are not mixed. No new percentages, RR, event totals, P values or CI are calculated."
    },
    {
      "item_id": "N09",
      "question_type": "Comparative efficacy",
      "question": "Are the risk-difference direction and 90% CI preserved as originally recorded?",
      "needed": "Risk difference of interest, arm order, CI level and original model",
      "role": "Required",
      "role_reason": "Individual production conditions recording original selected claims, comparisons, denominators, periods and interpretive limits",
      "application_exception": "Unread external material, other questions or out-of-scope outcomes do not substitute for satisfied conditions, zero effect or safety.",
      "criterion": "Risk difference of interest, arm order, CI level and original model",
      "basis": "Noninferior 90-day surgical-site infection",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Obtain the original comparison direction, risk-difference model, CI calculation and denominators.",
      "current_reports": [
        "R01"
      ],
      "existence": "Material information recorded in the preserved review summary",
      "acquired_read": "Summary read; external materials not read",
      "observation": "The original SSI risk difference is −3.8%p (90% CI −11.1~3.4).",
      "condition_status": "Partly verified",
      "status_reason": "Only the relevant preserved-summary information is recorded; detailed original materials are unread and existing content review remains incomplete. 90% is not changed to 95%. No new reverse-direction effect, risk ratio, test P value or adjusted model is produced. Details of the original risk-difference calculation remain unread.",
      "missingness": "90% is not changed to 95%. No new reverse-direction effect, risk ratio, test P value or adjusted model is produced. Details of the original risk-difference calculation remain unread.",
      "uncertainty": "Unread/unverified does not mean zero effect, zero events, safety or new clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "90% is not changed to 95%. No new reverse-direction effect, risk ratio, test P value or adjusted model is produced. Details of the original risk-difference calculation remain unread."
    },
    {
      "item_id": "N10",
      "question_type": "Comparative efficacy",
      "question": "Are the prespecified 10%p noninferiority margin and scope of the original conclusion distinguished?",
      "needed": "Margin, direction, rationale, prespecification, CI and plans",
      "role": "Required",
      "role_reason": "Individual production conditions recording original selected claims, comparisons, denominators, periods and interpretive limits",
      "application_exception": "Unread external material, other questions or out-of-scope outcomes do not substitute for satisfied conditions, zero effect or safety.",
      "criterion": "Margin, direction, rationale, prespecification, CI and plans",
      "basis": "Noninferior 90-day surgical-site infection",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Obtain the margin rationale, prespecification, testing and analysis plans, and original CI.",
      "current_reports": [
        "R01"
      ],
      "existence": "Material information recorded in the preserved review summary",
      "acquired_read": "Summary read; external materials not read",
      "observation": "The original materials state that the prespecified 10%p noninferiority margin was met, with 90% CI −11.1~3.4.",
      "condition_status": "Partly verified",
      "status_reason": "Only the relevant preserved-summary information is recorded; detailed original materials are unread and existing content review remains incomplete. No new certification is made without reading the clinical margin rationale, original assumptions, α, test P value and plans. No new margin or examples of allowable events are produced.",
      "missingness": "No new certification is made without reading the clinical margin rationale, original assumptions, α, test P value and plans. No new margin or examples of allowable events are produced.",
      "uncertainty": "Unread/unverified does not mean zero effect, zero events, safety or new clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "No new certification is made without reading the clinical margin rationale, original assumptions, α, test P value and plans. No new margin or examples of allowable events are produced."
    },
    {
      "item_id": "N11",
      "question_type": "Comparative efficacy",
      "question": "Has noninferiority been kept separate from superiority for reducing infection and exact equivalence?",
      "needed": "Original design, effect, interval, hypothesis and interpretation",
      "role": "Required",
      "role_reason": "Individual production conditions recording original selected claims, comparisons, denominators, periods and interpretive limits",
      "application_exception": "Unread external material, other questions or out-of-scope outcomes do not substitute for satisfied conditions, zero effect or safety.",
      "criterion": "Original design, effect, interval, hypothesis and interpretation",
      "basis": "Noninferior 90-day surgical-site infection",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Link the original hypothesis, interval, margin and effect interpretation to the relevant question.",
      "current_reports": [
        "R01"
      ],
      "existence": "Material information recorded in the preserved review summary",
      "acquired_read": "Summary read; external materials not read",
      "observation": "The original trial used a noninferiority design and records SSI risk difference −3.8%p and 90% CI −11.1~3.4.",
      "condition_status": "Partly verified",
      "status_reason": "Only the relevant preserved-summary information is recorded; detailed original materials are unread and existing content review remains incomplete. The direction of the original percentages alone does not establish superiority for reducing infection or equivalence with exactly no difference.",
      "missingness": "The direction of the original percentages alone does not establish superiority for reducing infection or equivalence with exactly no difference.",
      "uncertainty": "Unread/unverified does not mean zero effect, zero events, safety or new clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "The direction of the original percentages alone does not establish superiority for reducing infection or equivalence with exactly no difference."
    },
    {
      "item_id": "N12",
      "question_type": "Comparative efficacy",
      "question": "Are the per-protocol primary analysis and gaps in ITT and sensitivity analyses distinguished?",
      "needed": "Original PP, ITT, cancellation, adherence, missingness and sensitivity-analysis definitions",
      "role": "Required",
      "role_reason": "Individual production conditions recording original selected claims, comparisons, denominators, periods and interpretive limits",
      "application_exception": "Unread external material, other questions or out-of-scope outcomes do not substitute for satisfied conditions, zero effect or safety.",
      "criterion": "Original PP, ITT, cancellation, adherence, missingness and sensitivity-analysis definitions",
      "basis": "Noninferior 90-day surgical-site infection",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Obtain the original PP/ITT definitions, exclusions, adherence, missing-data assumptions, sensitivity analyses and original CI.",
      "current_reports": [
        "R01"
      ],
      "existence": "Material information recorded in the preserved review summary",
      "acquired_read": "Summary read; external materials not read",
      "observation": "The prespecified per-protocol primary analysis included 193 participants after excluding 3 canceled surgeries.",
      "condition_status": "Partly verified",
      "status_reason": "Only the relevant preserved-summary information is recorded; detailed original materials are unread and existing content review remains incomplete. This analysis is not converted into an ITT analysis of all 196 randomized participants. Details of ITT, sensitivity analyses, arm-specific cancellations, losses and original analysis mapping are unavailable.",
      "missingness": "This analysis is not converted into an ITT analysis of all 196 randomized participants. Details of ITT, sensitivity analyses, arm-specific cancellations, losses and original analysis mapping are unavailable.",
      "uncertainty": "Unread/unverified does not mean zero effect, zero events, safety or new clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "This analysis is not converted into an ITT analysis of all 196 randomized participants. Details of ITT, sensitivity analyses, arm-specific cancellations, losses and original analysis mapping are unavailable."
    },
    {
      "item_id": "N13",
      "question_type": "Comparative efficacy",
      "question": "What are the follow-up, missingness and ascertainment limits within the original infection period?",
      "needed": "90-day follow-up, visits, administrative/clinical ascertainment, missingness and denominators",
      "role": "Required",
      "role_reason": "Individual production conditions recording original selected claims, comparisons, denominators, periods and interpretive limits",
      "application_exception": "Unread external material, other questions or out-of-scope outcomes do not substitute for satisfied conditions, zero effect or safety.",
      "criterion": "90-day follow-up, visits, administrative/clinical ascertainment, missingness and denominators",
      "basis": "Noninferior 90-day surgical-site infection",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Obtain the original follow-up, infection ascertainment, missingness, denominators and handling of events outside the study center.",
      "current_reports": [
        "R01"
      ],
      "existence": "Material information recorded in the preserved review summary",
      "acquired_read": "Summary read; external materials not read",
      "observation": "The original primary endpoint period is 90 days, and the SSI analysis denominators are 95/98.",
      "condition_status": "Partly verified",
      "status_reason": "Only the relevant preserved-summary information is recorded; detailed original materials are unread and existing content review remains incomplete. These denominators alone do not certify complete follow-up of all randomized participants, capture of infections at outside healthcare facilities or absence of missing information.",
      "missingness": "These denominators alone do not certify complete follow-up of all randomized participants, capture of infections at outside healthcare facilities or absence of missing information.",
      "uncertainty": "Unread/unverified does not mean zero effect, zero events, safety or new clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "These denominators alone do not certify complete follow-up of all randomized participants, capture of infections at outside healthcare facilities or absence of missing information."
    },
    {
      "item_id": "N14",
      "question_type": "Comparative efficacy",
      "question": "Is antibiotic duration the same outcome as SSI?",
      "needed": "Distinguishing exposure duration, endpoint, summary statistics and denominators",
      "role": "Required",
      "role_reason": "Individual production conditions recording original selected claims, comparisons, denominators, periods and interpretive limits",
      "application_exception": "Unread external material, other questions or out-of-scope outcomes do not substitute for satisfied conditions, zero effect or safety.",
      "criterion": "Distinguishing exposure duration, endpoint, summary statistics and denominators",
      "basis": "Noninferior 90-day surgical-site infection",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Share the exposure outcome with the related question while linking it separately from the direct infection outcome.",
      "current_reports": [
        "R01"
      ],
      "existence": "Material information recorded in the preserved review summary",
      "acquired_read": "Summary read; external materials not read",
      "observation": "In the same trial, antibiotic duration was 1 day (IQR1~1) versus 8 days (IQR7~10), with the original reduction of 7 days and 87.5%.",
      "condition_status": "Partly verified",
      "status_reason": "Only the relevant preserved-summary information is recorded; detailed original materials are unread and existing content review remains incomplete. Reduced duration is not combined with SSI reduction, direct resistance reduction or safety as the same effect. Details of exposure-analysis denominators and hierarchy remain unread.",
      "missingness": "Reduced duration is not combined with SSI reduction, direct resistance reduction or safety as the same effect. Details of exposure-analysis denominators and hierarchy remain unread.",
      "uncertainty": "Unread/unverified does not mean zero effect, zero events, safety or new clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Reduced duration is not combined with SSI reduction, direct resistance reduction or safety as the same effect. Details of exposure-analysis denominators and hierarchy remain unread."
    },
    {
      "item_id": "N15",
      "question_type": "Comparative efficacy",
      "question": "Are clinical importance and original small-study limitations preserved without new assessment?",
      "needed": "Infection, margin, precision, sample size and original limitations",
      "role": "Required",
      "role_reason": "Individual production conditions recording original selected claims, comparisons, denominators, periods and interpretive limits",
      "application_exception": "Unread external material, other questions or out-of-scope outcomes do not substitute for satisfied conditions, zero effect or safety.",
      "criterion": "Infection, margin, precision, sample size and original limitations",
      "basis": "Noninferior 90-day surgical-site infection",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Obtain the original sample-size assumptions, clinical margin rationale and precision information.",
      "current_reports": [
        "R01"
      ],
      "existence": "Material information recorded in the preserved review summary",
      "acquired_read": "Summary read; external materials not read",
      "observation": "The parent record describes objective 90-day SSI and a prespecified margin as strengths, and noninferiority, small size and exclusion of canceled surgery as limitations, preserving C56.",
      "condition_status": "Partly verified",
      "status_reason": "Only the relevant preserved-summary information is recorded; detailed original materials are unread and existing content review remains incomplete. Unrecorded precision, the original parent verdict and axes are not repurposed as a new or subclaim score. No new sample-size, power or MCID calculations are made.",
      "missingness": "Unrecorded precision, the original parent verdict and axes are not repurposed as a new or subclaim score. No new sample-size, power or MCID calculations are made.",
      "uncertainty": "Unread/unverified does not mean zero effect, zero events, safety or new clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Unrecorded precision, the original parent verdict and axes are not repurposed as a new or subclaim score. No new sample-size, power or MCID calculations are made."
    },
    {
      "item_id": "N16",
      "question_type": "Comparative efficacy",
      "question": "Are the two subclaims from the same trial kept separate from independent replications?",
      "needed": "Relationships among report, trial, shared participants, outcomes and related questions",
      "role": "Required",
      "role_reason": "Individual production conditions recording original selected claims, comparisons, denominators, periods and interpretive limits",
      "application_exception": "Unread external material, other questions or out-of-scope outcomes do not substitute for satisfied conditions, zero effect or safety.",
      "criterion": "Relationships among report, trial, shared participants, outcomes and related questions",
      "basis": "Noninferior 90-day surgical-site infection",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Link additional reports while preserving original identifiers and population and time-point relationships.",
      "current_reports": [
        "R01"
      ],
      "existence": "Material information recorded in the preserved review summary",
      "acquired_read": "Summary read; external materials not read",
      "observation": "One PAPRAC report records both 90-day SSI and antibiotic duration, so the two subclaim tables share the same trial and population.",
      "condition_status": "Partly verified",
      "status_reason": "Only the relevant preserved-summary information is recorded; detailed original materials are unread and existing content review remains incomplete. Report entries, two questions, outcomes and time points are not added as new independent trials or participants. Final independent-study and total-participant counts remain unrecorded.",
      "missingness": "Report entries, two questions, outcomes and time points are not added as new independent trials or participants. Final independent-study and total-participant counts remain unrecorded.",
      "uncertainty": "Unread/unverified does not mean zero effect, zero events, safety or new clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Report entries, two questions, outcomes and time points are not added as new independent trials or participants. Final independent-study and total-participant counts remain unrecorded."
    },
    {
      "item_id": "N17",
      "question_type": "Comparative efficacy",
      "question": "What is known about company and institutional funding, in-kind support, affiliations and analysis roles?",
      "needed": "Cash, products/in-kind support, author affiliations, external analysis and study roles",
      "role": "Required",
      "role_reason": "Individual production conditions recording original selected claims, comparisons, denominators, periods and interpretive limits",
      "application_exception": "Unread external material, other questions or out-of-scope outcomes do not substitute for satisfied conditions, zero effect or safety.",
      "criterion": "Cash, products/in-kind support, author affiliations, external analysis and study roles",
      "basis": "Noninferior 90-day surgical-site infection",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Obtain the original support, in-kind, affiliation, analysis, design and writing disclosures separately.",
      "current_reports": [
        "R01"
      ],
      "existence": "Material information recorded in the preserved review summary",
      "acquired_read": "Summary read; external materials not read",
      "observation": "The original summary records no reported external grant or company in-kind support, and sponsorship and conduct by Insel Gruppe AG and University Hospital Bern.",
      "condition_status": "Partly verified",
      "status_reason": "Only the relevant preserved-summary information is recorded; detailed original materials are unread and existing content review remains incomplete. No reported support is not converted into certification of no support or company involvement. Separate details of employee authors, external analysis, design and writing roles remain unread.",
      "missingness": "No reported support is not converted into certification of no support or company involvement. Separate details of employee authors, external analysis, design and writing roles remain unread.",
      "uncertainty": "Unread/unverified does not mean zero effect, zero events, safety or new clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "No reported support is not converted into certification of no support or company involvement. Separate details of employee authors, external analysis, design and writing roles remain unread."
    },
    {
      "item_id": "N18",
      "question_type": "Supplementary harm evidence",
      "question": "Are 90-day mortality counts, denominators and P distinguished from SSI?",
      "needed": "Mortality definition, duration, arm-specific denominators, original events and testing",
      "role": "Required",
      "role_reason": "Individual production conditions recording original selected claims, comparisons, denominators, periods and interpretive limits",
      "application_exception": "Unread external material, other questions or out-of-scope outcomes do not substitute for satisfied conditions, zero effect or safety.",
      "criterion": "Mortality definition, duration, arm-specific denominators, original events and testing",
      "basis": "Noninferior 90-day surgical-site infection",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Obtain original mortality, relatedness, denominator, plan, CI and follow-up materials.",
      "current_reports": [
        "R01"
      ],
      "existence": "Material information recorded in the preserved review summary",
      "acquired_read": "Summary read; external materials not read",
      "observation": "The original safety record gives 90-day all-cause mortality as 6/95 (6.3%) versus 5/98 (5.1%), P=.96.",
      "condition_status": "Partly verified",
      "status_reason": "Only the relevant preserved-summary information is recorded; detailed original materials are unread and existing content review remains incomplete. These results are not converted into antibiotic-related mortality, survival noninferiority or absence of rare harms. CI, causes, relatedness and hierarchy for the original mortality outcome remain unread, with no new calculation.",
      "missingness": "These results are not converted into antibiotic-related mortality, survival noninferiority or absence of rare harms. CI, causes, relatedness and hierarchy for the original mortality outcome remain unread, with no new calculation.",
      "uncertainty": "Unread/unverified does not mean zero effect, zero events, safety or new clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "These results are not converted into antibiotic-related mortality, survival noninferiority or absence of rare harms. CI, causes, relatedness and hierarchy for the original mortality outcome remain unread, with no new calculation."
    },
    {
      "item_id": "N19",
      "question_type": "Supplementary harm evidence",
      "question": "What do the infection-resolution statement and treatment and safety collection cover?",
      "needed": "Infection types, treatment exposure, follow-up, recovery, relatedness and denominators",
      "role": "Required",
      "role_reason": "Individual production conditions recording original selected claims, comparisons, denominators, periods and interpretive limits",
      "application_exception": "Unread external material, other questions or out-of-scope outcomes do not substitute for satisfied conditions, zero effect or safety.",
      "criterion": "Infection types, treatment exposure, follow-up, recovery, relatedness and denominators",
      "basis": "Noninferior 90-day surgical-site infection",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Obtain original infection, treatment-exposure, treatment-success definition, follow-up, relatedness and denominator records.",
      "current_reports": [
        "R01"
      ],
      "existence": "Material information recorded in the preserved review summary",
      "acquired_read": "Summary read; external materials not read",
      "observation": "The original safety record states that all infections resolved with appropriate treatment.",
      "condition_status": "Partly verified",
      "status_reason": "Only the relevant preserved-summary information is recorded; detailed original materials are unread and existing content review remains incomplete. This statement is not extended to mean no infections, systematic collection of all harms or no risk. Details of other infections, treatments, people/events and recovery timing remain unread.",
      "missingness": "This statement is not extended to mean no infections, systematic collection of all harms or no risk. Details of other infections, treatments, people/events and recovery timing remain unread.",
      "uncertainty": "Unread/unverified does not mean zero effect, zero events, safety or new clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "This statement is not extended to mean no infections, systematic collection of all harms or no risk. Details of other infections, treatments, people/events and recovery timing remain unread."
    },
    {
      "item_id": "N20",
      "question_type": "Supplementary harm evidence",
      "question": "Does shorter antibiotic exposure directly demonstrate reduced harms?",
      "needed": "Drug harms, collection, exposure, arm-specific events and denominators",
      "role": "Required",
      "role_reason": "Individual production conditions recording original selected claims, comparisons, denominators, periods and interpretive limits",
      "application_exception": "Unread external material, other questions or out-of-scope outcomes do not substitute for satisfied conditions, zero effect or safety.",
      "criterion": "Drug harms, collection, exposure, arm-specific events and denominators",
      "basis": "Noninferior 90-day surgical-site infection",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Obtain original harm-collection records, arm-specific events/people, exposure, discontinuation, relatedness and duration.",
      "current_reports": [
        "R01"
      ],
      "existence": "Material information recorded in the preserved review summary",
      "acquired_read": "Summary read; external materials not read",
      "observation": "The original materials record shorter prophylactic antibiotic exposure, 90-day SSI and mortality; parent safety is Caution.",
      "condition_status": "Unverified",
      "status_reason": "Only the relevant preserved-summary information is recorded; detailed original materials are unread and existing content review remains incomplete. Shorter exposure alone does not newly establish reductions in adverse drug reactions, kidney injury, allergy or other harms. The summary lacks the relevant original outcomes, denominators and collection details.",
      "missingness": "Shorter exposure alone does not newly establish reductions in adverse drug reactions, kidney injury, allergy or other harms. The summary lacks the relevant original outcomes, denominators and collection details.",
      "uncertainty": "Unread/unverified does not mean zero effect, zero events, safety or new clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Shorter exposure alone does not newly establish reductions in adverse drug reactions, kidney injury, allergy or other harms. The summary lacks the relevant original outcomes, denominators and collection details."
    },
    {
      "item_id": "N21",
      "question_type": "Supplementary harm evidence",
      "question": "Are resistance selection pressure, individual resistance, costs and other infections distinguished?",
      "needed": "Direct outcomes, definitions and denominators for resistance, costs and infection types",
      "role": "Required",
      "role_reason": "Individual production conditions recording original selected claims, comparisons, denominators, periods and interpretive limits",
      "application_exception": "Unread external material, other questions or out-of-scope outcomes do not substitute for satisfied conditions, zero effect or safety.",
      "criterion": "Direct outcomes, definitions and denominators for resistance, costs and infection types",
      "basis": "Noninferior 90-day surgical-site infection",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Obtain prespecified direct measurements, denominators, effects and follow-up for resistance, costs and other infections.",
      "current_reports": [
        "R01"
      ],
      "existence": "Material information recorded in the preserved review summary",
      "acquired_read": "Summary read; external materials not read",
      "observation": "The original review summary records both a possible reduction in resistance selection pressure and costs through less exposure, and the limitation that individual resistance emergence and costs were not directly tested.",
      "condition_status": "Unverified",
      "status_reason": "Only the relevant preserved-summary information is recorded; detailed original materials are unread and existing content review remains incomplete. Mechanistic or stewardship advantages are not converted into established direct reductions in resistance or costs or prevention of other infections.",
      "missingness": "Mechanistic or stewardship advantages are not converted into established direct reductions in resistance or costs or prevention of other infections.",
      "uncertainty": "Unread/unverified does not mean zero effect, zero events, safety or new clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Mechanistic or stewardship advantages are not converted into established direct reductions in resistance or costs or prevention of other infections."
    },
    {
      "item_id": "N22",
      "question_type": "Supplementary harm evidence",
      "question": "What application gaps remain for populations, surgery, drugs and resistance environments outside the single center?",
      "needed": "Direct comparisons in new populations, surgeries, drug combinations and settings",
      "role": "Required",
      "role_reason": "Individual production conditions recording original selected claims, comparisons, denominators, periods and interpretive limits",
      "application_exception": "Unread external material, other questions or out-of-scope outcomes do not substitute for satisfied conditions, zero effect or safety.",
      "criterion": "Direct comparisons in new populations, surgeries, drug combinations and settings",
      "basis": "Noninferior 90-day surgical-site infection",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Obtain direct effects/harms, denominators and follow-up for each new population, surgery, drug and setting.",
      "current_reports": [
        "R01"
      ],
      "existence": "Material information recorded in the preserved review summary",
      "acquired_read": "Summary read; external materials not read",
      "observation": "The parent counterview records that results cannot be directly applied to robotic surgery, other antibiotic combinations or different resistance environments.",
      "condition_status": "Unverified",
      "status_reason": "Only the relevant preserved-summary information is recorded; detailed original materials are unread and existing content review remains incomplete. No individual antibiotic choice, duration, postoperative-care or treatment-substitution guidance is generated. Efficacy and safety outside the original study conditions are not newly certified.",
      "missingness": "No individual antibiotic choice, duration, postoperative-care or treatment-substitution guidance is generated. Efficacy and safety outside the original study conditions are not newly certified.",
      "uncertainty": "Unread/unverified does not mean zero effect, zero events, safety or new clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "No individual antibiotic choice, duration, postoperative-care or treatment-substitution guidance is generated. Efficacy and safety outside the original study conditions are not newly certified."
    },
    {
      "item_id": "N23",
      "question_type": "Comparative efficacy",
      "question": "Do gaps remain in durability beyond 90 days and independent replication?",
      "needed": "Long-term follow-up, new trials, populations, centers and independence relationships",
      "role": "Required",
      "role_reason": "Individual production conditions recording original selected claims, comparisons, denominators, periods and interpretive limits",
      "application_exception": "Unread external material, other questions or out-of-scope outcomes do not substitute for satisfied conditions, zero effect or safety.",
      "criterion": "Long-term follow-up, new trials, populations, centers and independence relationships",
      "basis": "Noninferior 90-day surgical-site infection",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Obtain long-term direct outcomes, independent-report relationships and center-specific materials.",
      "current_reports": [
        "R01"
      ],
      "existence": "Material information recorded in the preserved review summary",
      "acquired_read": "Summary read; external materials not read",
      "observation": "The currently designated preserved summary contains one PAPRAC report and 90-day SSI.",
      "condition_status": "Partly verified",
      "status_reason": "Only the relevant preserved-summary information is recorded; detailed original materials are unread and existing content review remains incomplete. Duration, outcomes and related tables are not counted as replication trials or extended to long-term resistance, readmission, mortality or all infections.",
      "missingness": "Duration, outcomes and related tables are not counted as replication trials or extended to long-term resistance, readmission, mortality or all infections.",
      "uncertainty": "Unread/unverified does not mean zero effect, zero events, safety or new clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Duration, outcomes and related tables are not counted as replication trials or extended to long-term resistance, readmission, mortality or all infections."
    },
    {
      "item_id": "N24",
      "question_type": "Comparative efficacy",
      "question": "Are the preserved summary and external abstract, full text, registration and plans distinguished?",
      "needed": "Bibliography, existing links, registration identifiers and material-specific access status",
      "role": "Required",
      "role_reason": "Individual production conditions recording original selected claims, comparisons, denominators, periods and interpretive limits",
      "application_exception": "Unread external material, other questions or out-of-scope outcomes do not substitute for satisfied conditions, zero effect or safety.",
      "criterion": "Bibliography, existing links, registration identifiers and material-specific access status",
      "basis": "Noninferior 90-day surgical-site infection",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Link individual original materials supplied by the user separately from their actual access status.",
      "current_reports": [
        "R01"
      ],
      "existence": "Material information recorded in the preserved review summary",
      "acquired_read": "Summary read; external materials not read",
      "observation": "The complete parent-verdict summary was read for production, linking the existing PubMed URL for Thurnheer et al. 2024, PMID39422911 and identifier NCT03305627.",
      "condition_status": "Partly verified",
      "status_reason": "Only the relevant preserved-summary information is recorded; detailed original materials are unread and existing content review remains incomplete. External abstract, full text, registration, protocol and SAP remain unread; no separate link test was performed. No new URL or DOI is constructed from identifiers.",
      "missingness": "External abstract, full text, registration, protocol and SAP remain unread; no separate link test was performed. No new URL or DOI is constructed from identifiers.",
      "uncertainty": "Unread/unverified does not mean zero effect, zero events, safety or new clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "External abstract, full text, registration, protocol and SAP remain unread; no separate link test was performed. No new URL or DOI is constructed from identifiers."
    },
    {
      "item_id": "N25",
      "question_type": "Comparative efficacy",
      "question": "Are the reference date, Korean/English texts, corrections, empty values, candidate history and production state preserved?",
      "needed": "Distinguishing the complete preserved summary, selected verdict record, parent values, original languages and history",
      "role": "Supplementary",
      "role_reason": "Individual production conditions recording original selected claims, comparisons, denominators, periods and interpretive limits",
      "application_exception": "Unread external material, other questions or out-of-scope outcomes do not substitute for satisfied conditions, zero effect or safety.",
      "criterion": "Distinguishing the complete preserved summary, selected verdict record, parent values, original languages and history",
      "basis": "Noninferior 90-day surgical-site infection",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Preserve original texts before linking additional user materials or decisions as separate events.",
      "current_reports": [
        "R01"
      ],
      "existence": "Material information recorded in the preserved review summary",
      "acquired_read": "Summary read; external materials not read",
      "observation": "2026-08-26, empty correction and deliberation values, Korean/English texts, parent C56, Caution and axes, and the subclaim C grade and note are preserved in their original form.",
      "condition_status": "Partly verified",
      "status_reason": "Only the relevant preserved-summary information is recorded; detailed original materials are unread and existing content review remains incomplete. Original statements, including the sample-size wording in the parent rationale, remain historical records without new correction or reassessment. Original review-pending and production-eligibility indicators are candidate history, not current review or completion.",
      "missingness": "Original statements, including the sample-size wording in the parent rationale, remain historical records without new correction or reassessment. Original review-pending and production-eligibility indicators are candidate history, not current review or completion.",
      "uncertainty": "Unread/unverified does not mean zero effect, zero events, safety or new clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original statements, including the sample-size wording in the parent rationale, remain historical records without new correction or reassessment. Original review-pending and production-eligibility indicators are candidate history, not current review or completion."
    }
  ],
  "reports": [
    {
      "report_id": "R01",
      "title": "Thurnheer MC, et al. JAMA Netw Open. 2024;7:e2439382. PMID: 39422911.",
      "url": "https://pubmed.ncbi.nlm.nih.gov/39422911/",
      "report_type": "Noninferiority randomized-trial report",
      "existence": "Material preserved in the original citation/evidence lists",
      "acquired_read": "Summary read; external materials not read",
      "study_family": "F01",
      "independent_replication": false,
      "observed_result": "8.4% versus 12.2%, risk difference −3.8%p (90% CI −11.1~3.4), margin 10%p; duration 1 versus 8 days",
      "result_level": "Preserved summary; not a result of newly comparing the external original report",
      "source_evidence_date": "2026-08-26",
      "materials": [
        {
          "material_type": "local_summary",
          "public_status": "Existing link preserved",
          "access_status": "Summary read",
          "acquired": true,
          "actually_read": "Summary read",
          "as_of": "2026-08-26",
          "qualification": "Stored parent-verdict summary"
        },
        {
          "material_type": "abstract",
          "public_status": "Existing link preserved",
          "access_status": "Not read",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-08-26",
          "qualification": "External material unread; a URL does not mean acquisition, reading or completed review"
        },
        {
          "material_type": "fulltext",
          "public_status": "No separate URL in the original material",
          "access_status": "Not read",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-08-26",
          "qualification": "External material unread; a URL does not mean acquisition, reading or completed review"
        },
        {
          "material_type": "registration",
          "public_status": "No separate URL in the original material",
          "access_status": "Not read",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-08-26",
          "qualification": "External material unread; a URL does not mean acquisition, reading or completed review"
        },
        {
          "material_type": "protocol_sap",
          "public_status": "No separate URL in the original material",
          "access_status": "Not read",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-08-26",
          "qualification": "External material unread; a URL does not mean acquisition, reading or completed review"
        }
      ],
      "links": [
        {
          "label": "PubMed",
          "url": "https://pubmed.ncbi.nlm.nih.gov/39422911/"
        }
      ]
    }
  ],
  "method_sources": [
    {
      "id": "M03",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03",
      "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13",
      "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.",
      "review_level": "Preserved methodology connections were reused for preparation. No new review of methodological content, reassessment or external-link checks were performed."
    },
    {
      "id": "M04",
      "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04",
      "section": "§4.5, §4.6.1–4.6.3, MECIR C42",
      "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.",
      "review_level": "Preserved methodology connections were reused for preparation. No new review of methodological content, reassessment or external-link checks were performed."
    },
    {
      "id": "M08",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08",
      "section": "§8.1–8.2.3, Table 8.2.a",
      "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.",
      "review_level": "Preserved methodology connections were reused for preparation. No new review of methodological content, reassessment or external-link checks were performed."
    },
    {
      "id": "M15",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15",
      "section": "§15.2.4, §15.3.1–15.3.3",
      "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.",
      "review_level": "Preserved methodology connections were reused for preparation. No new review of methodological content, reassessment or external-link checks were performed."
    },
    {
      "id": "M19",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19",
      "section": "§19.1.2, §19.2.1–19.2.4",
      "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.",
      "review_level": "Preserved methodology connections were reused for preparation. No new review of methodological content, reassessment or external-link checks were performed."
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  "status_dictionary": {
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    "Unverified": "Detailed materials for the selected condition could not be established within the stored scope; this does not mean zero effect, zero studies or safety",
    "Review incomplete": "Existing content review pending",
    "Met": "Use only within the relevant conditions after existing content review; no automatic designation in this preparation",
    "Not reported": "Distinguish only within materials actually read; do not turn unread external materials into unreported findings",
    "Inaccessible": "Not applied during this preparation because actual access was not tested",
    "Not applicable": "Use with a reason for non-applicability based on an explicit question boundary",
    "Conflicting data": "Judge after actual material comparison; review was not performed during this preparation",
    "Insufficient evidence for the conditions": "Do not use as a clinical grade encompassing currently unread materials"
  },
  "study_overlap": {
    "state": "Unverified",
    "unique_trial_count": null,
    "unique_participant_count": null,
    "reason": "The same PAPRAC report and population for 90-day SSI and prophylactic-antibiotic exposure duration; shared by the two subclaims"
  },
  "history": [
    {
      "date": "2026-10-10",
      "kind": "Separation of public-facing pages and materials",
      "view_version": "1.0",
      "change": "The public page and data were prepared from the existing 25 items. No new clinical search, verification-status change or scoring was performed."
    }
  ],
  "language": "en",
  "translation_date": "2026-10-10"
}