{
  "schema_version": "chamgap-public-criteria-1.0",
  "title": "Darbepoetin alfa × Neurodevelopment in preterm infants — Evidence sheet with separate follow-up unverified",
  "language": "en",
  "translation_date": "2026-10-10",
  "criteria_version": "1.0",
  "criteria_date": "2026-10-06",
  "condition_origin": "Chamgap's own application conditions",
  "method_sources": [
    {
      "id": "M03",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03",
      "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13",
      "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.",
      "review_level": "Existing stored methodological links reused for preparation; no current review, reassessment of methodological content or external-link testing"
    },
    {
      "id": "M04",
      "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04",
      "section": "§4.5, §4.6.1–4.6.3, MECIR C42",
      "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.",
      "review_level": "Existing stored methodological links reused for preparation; no current review, reassessment of methodological content or external-link testing"
    },
    {
      "id": "M08",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08",
      "section": "§8.1–8.2.3, Table 8.2.a",
      "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.",
      "review_level": "Existing stored methodological links reused for preparation; no current review, reassessment of methodological content or external-link testing"
    },
    {
      "id": "M15",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15",
      "section": "§15.2.4, §15.3.1–15.3.3",
      "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.",
      "review_level": "Existing stored methodological links reused for preparation; no current review, reassessment of methodological content or external-link testing"
    },
    {
      "id": "M19",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19",
      "section": "§19.1.2, §19.2.1–19.2.4",
      "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.",
      "review_level": "Existing stored methodological links reused for preparation; no current review, reassessment of methodological content or external-link testing"
    }
  ],
  "status_dictionary": {
    "Partly verified": "Some information is in the stored summary; detailed original material remains unverified. This does not certify passed review or clinical efficacy",
    "Unverified": "Detailed materials for the selected condition could not be established within the stored scope; this does not mean zero effect, zero studies or safety",
    "Review incomplete": "Awaiting user review",
    "Met": "Use only within the relevant condition's scope after user review; no automatic display in this preparation",
    "Not reported": "Distinguish only within materials actually read; do not turn unread external materials into unreported findings",
    "Inaccessible": "Not applied during this preparation because actual access was not tested",
    "Not applicable": "Use with a reason for non-applicability based on an explicit question boundary",
    "Conflicting data": "Judge after actual material comparison; review was not performed during this preparation",
    "Insufficient evidence for the conditions": "Do not use as a clinical grade encompassing currently unread materials"
  },
  "requirements": [
    {
      "item_id": "N01",
      "question_type": "Comparative efficacy",
      "question": "Were the selected claim and its subclaim grade distinguished from the parent verdict?",
      "needed": "Separate preservation of the existing claim, grade, note and parent values",
      "role": "Required",
      "role_reason": "Case-specific production conditions recording the selected claim, endpoint, denominator, time, study identity and interpretation boundaries",
      "application_exception": "Unread material, other questions, other products and out-of-scope results do not stand in for fulfillment, zero effect or safety.",
      "criterion": "Separate preservation of the existing claim, grade, note and parent values",
      "basis": "Improved neurodevelopment",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Link additional material separately to each existing question and its parent context."
    },
    {
      "item_id": "N02",
      "question_type": "Comparative efficacy",
      "question": "What were the actual birth weight, enrollment timing and preterm population?",
      "needed": "Original eligibility, baseline, birth weight, enrollment age and denominators",
      "role": "Required",
      "role_reason": "Case-specific production conditions recording the selected claim, endpoint, denominator, time, study identity and interpretation boundaries",
      "application_exception": "Unread material, other questions, other products and out-of-scope results do not stand in for fulfillment, zero effect or safety.",
      "criterion": "Original eligibility, baseline, birth weight, enrollment age and denominators",
      "basis": "Improved neurodevelopment",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Obtain the original eligibility, baseline, weight, gestational age and enrollment/treatment timing material."
    },
    {
      "item_id": "N03",
      "question_type": "Comparative efficacy",
      "question": "Were darbepoetin and sham study identity distinguished from common care?",
      "needed": "Original drug, placebo/sham, concurrent treatment, baseline care and actual exposure",
      "role": "Required",
      "role_reason": "Case-specific production conditions recording the selected claim, endpoint, denominator, time, study identity and interpretation boundaries",
      "application_exception": "Unread material, other questions, other products and out-of-scope results do not stand in for fulfillment, zero effect or safety.",
      "criterion": "Original drug, placebo/sham, concurrent treatment, baseline care and actual exposure",
      "basis": "Improved neurodevelopment",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Obtain the original drug, sham, common care, concurrent treatment and actual exposure material."
    },
    {
      "item_id": "N04",
      "question_type": "Comparative efficacy",
      "question": "Are 10µg/kg once weekly and the stopping time historical exposure conditions?",
      "needed": "Original study plan, dose, frequency, stopping time and actual exposure",
      "role": "Required",
      "role_reason": "Case-specific production conditions recording the selected claim, endpoint, denominator, time, study identity and interpretation boundaries",
      "application_exception": "Unread material, other questions, other products and out-of-scope results do not stand in for fulfillment, zero effect or safety.",
      "criterion": "Original study plan, dose, frequency, stopping time and actual exposure",
      "basis": "Improved neurodevelopment",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Obtain the original exposure plan, age definitions and tables of actual completion, missed doses, dose reduction or discontinuation."
    },
    {
      "item_id": "N05",
      "question_type": "Comparative efficacy",
      "question": "Were 102 infants, 34 per arm and the three-arm design distinguished?",
      "needed": "Allocation, arm identity, arm-specific analyses, missing data and denominators",
      "role": "Required",
      "role_reason": "Case-specific production conditions recording the selected claim, endpoint, denominator, time, study identity and interpretation boundaries",
      "application_exception": "Unread material, other questions, other products and out-of-scope results do not stand in for fulfillment, zero effect or safety.",
      "criterion": "Allocation, arm identity, arm-specific analyses, missing data and denominators",
      "basis": "Improved neurodevelopment",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Obtain the original three-arm identities, allocation, analysis populations, missing data and participant flow."
    },
    {
      "item_id": "N06",
      "question_type": "Comparative efficacy",
      "question": "Were other study arms, other ESAs and verdict 2798 combined as the same result?",
      "needed": "Original arm identities, ESAs, comparisons, indications and outcome relationships",
      "role": "Required",
      "role_reason": "Case-specific production conditions recording the selected claim, endpoint, denominator, time, study identity and interpretation boundaries",
      "application_exception": "Unread material, other questions, other products and out-of-scope results do not stand in for fulfillment, zero effect or safety.",
      "criterion": "Original arm identities, ESAs, comparisons, indications and outcome relationships",
      "basis": "Improved neurodevelopment",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Obtain original material separately for each drug, arm, indication and direct comparison."
    },
    {
      "item_id": "N07",
      "question_type": "Comparative efficacy",
      "question": "What were the roles of standardized restrictive transfusion criteria and clinicians' decisions?",
      "needed": "Transfusion thresholds, Hb/Hct, respiratory support, symptoms, records and deviations",
      "role": "Required",
      "role_reason": "Case-specific production conditions recording the selected claim, endpoint, denominator, time, study identity and interpretation boundaries",
      "application_exception": "Unread material, other questions, other products and out-of-scope results do not stand in for fulfillment, zero effect or safety.",
      "criterion": "Transfusion thresholds, Hb/Hct, respiratory support, symptoms, records and deviations",
      "basis": "Improved neurodevelopment",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Obtain the original protocol, implementation/deviations, records, arm-specific criteria and denominators."
    },
    {
      "item_id": "N08",
      "question_type": "Comparative efficacy",
      "question": "Were mean transfusions per infant and the ± notation preserved as recorded?",
      "needed": "Original counts, statistic, dispersion, arm order, duration and denominators",
      "role": "Required",
      "role_reason": "Case-specific production conditions recording the selected claim, endpoint, denominator, time, study identity and interpretation boundaries",
      "application_exception": "Unread material, other questions, other products and out-of-scope results do not stand in for fulfillment, zero effect or safety.",
      "criterion": "Original counts, statistic, dispersion, arm order, duration and denominators",
      "basis": "Improved neurodevelopment",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Obtain the original dispersion type, denominators, duration, count distribution, model and test."
    },
    {
      "item_id": "N09",
      "question_type": "Comparative efficacy",
      "question": "Was the original absolute reduction of 1.2 transfusions distinguished from preventing an infant from receiving a transfusion?",
      "needed": "Original mean difference, effect, observation duration, denominators and uncertainty",
      "role": "Required",
      "role_reason": "Case-specific production conditions recording the selected claim, endpoint, denominator, time, study identity and interpretation boundaries",
      "application_exception": "Unread material, other questions, other products and out-of-scope results do not stand in for fulfillment, zero effect or safety.",
      "criterion": "Original mean difference, effect, observation duration, denominators and uncertainty",
      "basis": "Improved neurodevelopment",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Obtain the original mean difference, model, interval, test, duration and denominators."
    },
    {
      "item_id": "N10",
      "question_type": "Comparative efficacy",
      "question": "Were the hospitalization transfusion-free proportions of 59% and 38% distinguished from the original 21%p difference?",
      "needed": "Transfusion-free definition, people, duration, denominators and original difference",
      "role": "Required",
      "role_reason": "Case-specific production conditions recording the selected claim, endpoint, denominator, time, study identity and interpretation boundaries",
      "application_exception": "Unread material, other questions, other products and out-of-scope results do not stand in for fulfillment, zero effect or safety.",
      "criterion": "Transfusion-free definition, people, duration, denominators and original difference",
      "basis": "Improved neurodevelopment",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Obtain the original transfusion-free criteria, arm denominators, infant counts, duration, CI and test."
    },
    {
      "item_id": "N11",
      "question_type": "Comparative efficacy",
      "question": "Are transfusion counts, transfusion-free status and donor exposure the same measure?",
      "needed": "Counts, people, donors, blood volume and each denominator",
      "role": "Required",
      "role_reason": "Case-specific production conditions recording the selected claim, endpoint, denominator, time, study identity and interpretation boundaries",
      "application_exception": "Unread material, other questions, other products and out-of-scope results do not stand in for fulfillment, zero effect or safety.",
      "criterion": "Counts, people, donors, blood volume and each denominator",
      "basis": "Improved neurodevelopment",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Obtain the original definitions for each measure, people/events, denominators and donor/blood-volume material."
    },
    {
      "item_id": "N12",
      "question_type": "Comparative efficacy",
      "question": "Were the hospitalization/35-week stopping window and two-year developmental follow-up distinguished?",
      "needed": "Intervention window, transfusion observation window, follow-up age, original duration and denominators",
      "role": "Required",
      "role_reason": "Case-specific production conditions recording the selected claim, endpoint, denominator, time, study identity and interpretation boundaries",
      "application_exception": "Unread material, other questions, other products and out-of-scope results do not stand in for fulfillment, zero effect or safety.",
      "criterion": "Intervention window, transfusion observation window, follow-up age, original duration and denominators",
      "basis": "Improved neurodevelopment",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Obtain each original duration, age definition, exposure, discharge, follow-up and denominator."
    },
    {
      "item_id": "N13",
      "question_type": "Comparative efficacy",
      "question": "What were the original computer block allocation, caregiver/investigator masking and sham procedures?",
      "needed": "Original allocation, concealment, masking, transfusion records and analysts",
      "role": "Required",
      "role_reason": "Case-specific production conditions recording the selected claim, endpoint, denominator, time, study identity and interpretation boundaries",
      "application_exception": "Unread material, other questions, other products and out-of-scope results do not stand in for fulfillment, zero effect or safety.",
      "criterion": "Original allocation, concealment, masking, transfusion records and analysts",
      "basis": "Improved neurodevelopment",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Obtain the original allocation, masking, recording, analysis and missing-data procedures."
    },
    {
      "item_id": "N14",
      "question_type": "Comparative efficacy",
      "question": "What is the actual access status for primary transfusion, secondary developmental follow-up and registration plans?",
      "needed": "Original endpoint hierarchy, registration, protocol, SAP, changes and multiplicity",
      "role": "Required",
      "role_reason": "Case-specific production conditions recording the selected claim, endpoint, denominator, time, study identity and interpretation boundaries",
      "application_exception": "Unread material, other questions, other products and out-of-scope results do not stand in for fulfillment, zero effect or safety.",
      "criterion": "Original endpoint hierarchy, registration, protocol, SAP, changes and multiplicity",
      "basis": "Improved neurodevelopment",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Obtain original registration, plans, hierarchy, changes, multiplicity and analysis-population material."
    },
    {
      "item_id": "N15",
      "question_type": "Comparative efficacy",
      "question": "Were the main paper, separate follow-up and relationships among the same participants distinguished?",
      "needed": "Original reports, follow-up bibliography, registration, assessment age and population mapping",
      "role": "Required",
      "role_reason": "Case-specific production conditions recording the selected claim, endpoint, denominator, time, study identity and interpretation boundaries",
      "application_exception": "Unread material, other questions, other products and out-of-scope results do not stand in for fulfillment, zero effect or safety.",
      "criterion": "Original reports, follow-up bibliography, registration, assessment age and population mapping",
      "basis": "Improved neurodevelopment",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Obtain the original follow-up bibliography, registration, arm-specific assessments and population/follow-up mapping."
    },
    {
      "item_id": "N16",
      "question_type": "Comparative efficacy",
      "question": "What are the gaps in direct neurodevelopmental effects, instruments and denominators?",
      "needed": "Original follow-up paper, assessment instruments, original scales, arm denominators, effects and intervals",
      "role": "Required",
      "role_reason": "Case-specific production conditions recording the selected claim, endpoint, denominator, time, study identity and interpretation boundaries",
      "application_exception": "Unread material, other questions, other products and out-of-scope results do not stand in for fulfillment, zero effect or safety.",
      "criterion": "Original follow-up paper, assessment instruments, original scales, arm denominators, effects and intervals",
      "basis": "Improved neurodevelopment",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Obtain the original follow-up paper, instruments, denominators, models, effects, intervals and tests."
    },
    {
      "item_id": "N17",
      "question_type": "Comparative efficacy",
      "question": "Were two-year assessment age, survivors, dropout, missing data and repeated assessments distinguished?",
      "needed": "Corrected/chronological age, assessment population, survival, dropout, instruments and missing-data handling",
      "role": "Required",
      "role_reason": "Case-specific production conditions recording the selected claim, endpoint, denominator, time, study identity and interpretation boundaries",
      "application_exception": "Unread material, other questions, other products and out-of-scope results do not stand in for fulfillment, zero effect or safety.",
      "criterion": "Corrected/chronological age, assessment population, survival, dropout, instruments and missing-data handling",
      "basis": "Improved neurodevelopment",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Obtain the original assessment age, survival/follow-up flow, arm denominators, instruments and missing-data handling."
    },
    {
      "item_id": "N18",
      "question_type": "Comparative efficacy",
      "question": "Were primary/secondary hierarchy, multiple developmental scales and clinical function established?",
      "needed": "Original secondary-outcome plan, scales, multiplicity, models, function and plan changes",
      "role": "Required",
      "role_reason": "Case-specific production conditions recording the selected claim, endpoint, denominator, time, study identity and interpretation boundaries",
      "application_exception": "Unread material, other questions, other products and out-of-scope results do not stand in for fulfillment, zero effect or safety.",
      "criterion": "Original secondary-outcome plan, scales, multiplicity, models, function and plan changes",
      "basis": "Improved neurodevelopment",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Obtain the original follow-up plan, scales, hierarchy, changes, multiplicity and clinical-function material."
    },
    {
      "item_id": "N19",
      "question_type": "Comparative efficacy",
      "question": "Was a separate follow-up report certified as an independent trial or individual neuroprotection?",
      "needed": "Original trial, same population, follow-up bibliography, drugs and direct long-term outcomes",
      "role": "Required",
      "role_reason": "Case-specific production conditions recording the selected claim, endpoint, denominator, time, study identity and interpretation boundaries",
      "application_exception": "Unread material, other questions, other products and out-of-scope results do not stand in for fulfillment, zero effect or safety.",
      "criterion": "Original trial, same population, follow-up bibliography, drugs and direct long-term outcomes",
      "basis": "Improved neurodevelopment",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Obtain the original registration, follow-up bibliography, same-population mapping and direct long-term outcomes."
    },
    {
      "item_id": "N20",
      "question_type": "Comparative efficacy",
      "question": "What are the small-study, original sample-size design and precision gaps?",
      "needed": "Original size, assumptions, plan, dropout, intervals and clinical importance",
      "role": "Required",
      "role_reason": "Case-specific production conditions recording the selected claim, endpoint, denominator, time, study identity and interpretation boundaries",
      "application_exception": "Unread material, other questions, other products and out-of-scope results do not stand in for fulfillment, zero effect or safety.",
      "criterion": "Original size, assumptions, plan, dropout, intervals and clinical importance",
      "basis": "Improved neurodevelopment",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Obtain the original size assumptions, power, dropout handling, intervals and clinical boundaries."
    },
    {
      "item_id": "N21",
      "question_type": "Comparative efficacy",
      "question": "Were public/nonprofit research funding and Amgen antibody assays distinguished?",
      "needed": "Cash, products/in-kind support, assay provision, affiliations, analysis and roles",
      "role": "Required",
      "role_reason": "Case-specific production conditions recording the selected claim, endpoint, denominator, time, study identity and interpretation boundaries",
      "application_exception": "Unread material, other questions, other products and out-of-scope results do not stand in for fulfillment, zero effect or safety.",
      "criterion": "Cash, products/in-kind support, assay provision, affiliations, analysis and roles",
      "basis": "Improved neurodevelopment",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Obtain original disclosures of cash, drugs/in-kind support, assays, affiliations, design, analysis and writing."
    },
    {
      "item_id": "N22",
      "question_type": "Supplementary harm evidence",
      "question": "Were similar prematurity morbidity/ROP and the original safety denominators distinguished?",
      "needed": "Harm definitions, grades, events/people, exposure, denominators and relatedness",
      "role": "Required",
      "role_reason": "Case-specific production conditions recording the selected claim, endpoint, denominator, time, study identity and interpretation boundaries",
      "application_exception": "Unread material, other questions, other products and out-of-scope results do not stand in for fulfillment, zero effect or safety.",
      "criterion": "Harm definitions, grades, events/people, exposure, denominators and relatedness",
      "basis": "Improved neurodevelopment",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Obtain original harm definitions, arm-specific events/people, denominators, exposure, relatedness and tests."
    },
    {
      "item_id": "N23",
      "question_type": "Supplementary harm evidence",
      "question": "Was a trial with 102 infants used to exclude rare/long-term harms or discontinuations?",
      "needed": "Rare harms, actual exposure, duration, discontinuations and safety population",
      "role": "Required",
      "role_reason": "Case-specific production conditions recording the selected claim, endpoint, denominator, time, study identity and interpretation boundaries",
      "application_exception": "Unread material, other questions, other products and out-of-scope results do not stand in for fulfillment, zero effect or safety.",
      "criterion": "Rare harms, actual exposure, duration, discontinuations and safety population",
      "basis": "Improved neurodevelopment",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Obtain the original safety population, actual exposure, discontinuations, collection and rare/long-term harm material."
    },
    {
      "item_id": "N24",
      "question_type": "Supplementary harm evidence",
      "question": "Were development and other ESAs/indications combined as the same harm or clinical effect?",
      "needed": "Developmental outcomes, other drugs, populations, indications and direct comparisons",
      "role": "Required",
      "role_reason": "Case-specific production conditions recording the selected claim, endpoint, denominator, time, study identity and interpretation boundaries",
      "application_exception": "Unread material, other questions, other products and out-of-scope results do not stand in for fulfillment, zero effect or safety.",
      "criterion": "Developmental outcomes, other drugs, populations, indications and direct comparisons",
      "basis": "Improved neurodevelopment",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Obtain direct effects/harms and report relationships for each population, drug and indication."
    },
    {
      "item_id": "N25",
      "question_type": "Comparative efficacy",
      "question": "Were original bibliography, cross-citations, registration identifiers and access to follow-up material distinguished?",
      "needed": "Reports/related verdicts, original URLs, registration and material-specific access status",
      "role": "Required",
      "role_reason": "Case-specific production conditions recording the selected claim, endpoint, denominator, time, study identity and interpretation boundaries",
      "application_exception": "Unread material, other questions, other products and out-of-scope results do not stand in for fulfillment, zero effect or safety.",
      "criterion": "Reports/related verdicts, original URLs, registration and material-specific access status",
      "basis": "Improved neurodevelopment",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Link user-provided original material by report type, assessment age and access status."
    },
    {
      "item_id": "N26",
      "question_type": "Comparative efficacy",
      "question": "Were the Korean/English texts, axes, reference date, corrections, empty values, candidate history and production status retained?",
      "needed": "Distinguishing the selected verdict record, complete parent, languages and history from current production",
      "role": "Supplementary",
      "role_reason": "Case-specific production conditions recording the selected claim, endpoint, denominator, time, study identity and interpretation boundaries",
      "application_exception": "Unread material, other questions, other products and out-of-scope results do not stand in for fulfillment, zero effect or safety.",
      "criterion": "Distinguishing the selected verdict record, complete parent, languages and history from current production",
      "basis": "Improved neurodevelopment",
      "condition_origin": "Individual production conditions; not completed review or automatic satisfaction of common definitions",
      "proposed_research": "Link only user material/decisions as separate events after preserving the complete original text."
    }
  ]
}